FILED: KINGS COUNTY CLERK 07/07/2017 11:09 AM
`FILED: KINGS COUNTY CLERK 07m2017 11:09 AM
`NYSC 3F DOC. NO. 24
`NYSCEF DOC. NO. 24
`
`IND
`EX NO.
`501276/2015
`INDEX NO. 501276/2015
`
` VYSC
`
` *uIV‘ .D
` 3F:
`
`07/07/2017
`RECEIVED NYSCEF: 07/07/2017
`
`Exhibit “K”
`
`

`

`FILED: KINGS COUNTY CLERK 07/07/2017 11:09 AM
`NYSCEF DOC. NO. 24
`
`INDEX NO. 501276/2015
`
`
`RECEIVED NYSCEF: 07/07/2017
`
`
`
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`

`

`INDEX NO. 501276/2015
`FILED: KINGS COUNTY CLERK 07/07/2017 11:09 AM
`INDEX NO- 501276/2015
`FILED: KINGS COUNTY CLERK 07m2017 11:09 .
`l
`
`
`
`
`NY 8%917DOC . NO . 24
`Ibuprofen: Uses interactions. and side effects — Medical News “(1%)qu *.IV*.D \IYSCEF: 07 / 07 /2 0 l7
`NYSCEF DOC. NO. 24
`RECEIVED NYSCEF: 07/07/2017
`
`
`
`How does it work?
`
`Ibuprofen is an NSAID, a type of medication with analgesic,
`
`antipyretic (fever-reducing), and, in higher doses, anti—
`
`inflammatory effects.
`
`A non-steroidal drug is not a steroid. Steroids often have similar
`
`effects, but long-term use can cause severe adverse effects.
`
`
`
`Most NSAIDs are non-narcotic, so they do not cause insensibility
`
`ibuproren is an Nsmmhat is widely
`
`or Stupor.
`
`.
`
`-- Ankylosing Spondylitis
`
`ADVERTISEMENT
`
`available and reduces sweliing,
`inflammation. and pain.
`
`Get The Facts About AS Symptoms And What You Can Do TodayImvv-J.fanRyEosérangpcmiyEiiis~in{deem
`
`Ibuprofen, aspirin, and naproxen are all well-known NSAIDs, partly because they are available over
`
`the counter (OTC) from pharmacies.
`
`Ibuprofen works by blocking the production of prostaglandins, substances that the body releases in
`
`response to illness and injury.
`
`Prostaglandins cause pain and swelling, or inflammation. They are released in the brain, and they can
`
`also cause fever.
`
`Ibuprofen's painkilling effects begin soon after taking a dose. The anti-inflammatory effects can take
`
`longer, sometimes several weeks.
`
`http://www.medicaInewstoday.com/articles/161071.php
`
`1/1
`
`

`

`INDEX NO. 501276/2015
`FILED: KINGS COUNTY CLERK 07/07/2017 11:09 AM
`INDEX NO- 501276/2015
`FILED: KINGS COUNTY CLERK 07m2017 11:09 AM
`
`
`
`Nygé/figwt 7DOC . NO . 24
`Ibuprofen for pain and inflammation (Brufen, Calprofen, Nurofen) l MediCinfitgfiifQ/IED \IYSCEF: 07 / 07 /2 0 l7
`NYSCEF DOC. NO. 24
`RECEIVED NYSCEF: 07/07/2017
`
`View this article online at https://patient.info/medicine/ibuprofen-for-pain—and—inflammation—brufen-calprofen-
`nurofen
`
`Ibuprofen for pain and inflammation
`(Brufen2 Calprofen2 Nurofen)
`
`Ibuprofen is a medicine called a non-steroidal anti-inflammatory drug.
`is also known as ‘an NSAID'.
`
`It
`
`Speak with a doctor before taking ibuprofen if you have ever had a
`bad reaction to any other anti-inflammatory painkiller.
`Take ibuprofen with a meal or a snack.
`
`
`
`About ibuprofen
`
`Type of A non-steroidal anti-inflammatory drug (NSAID)
`
`medicine
`
`Used for Relief of pain, inflammation, or fever
`
`Also Brufen®; Calprofen®; Cuprofen®; Fenpaed®; |bucalm®; Mandafen®; Nurofen®;
`
`called Orbifen®
`
`Available Tablets, capsules, effervescent granules, oral liquid medicine, modified-release tablets,
`
`as orodispersible (melt in the mouth) tablets, chewable capsules for children
`
`Anti-inflammatory painkillers like ibuprofen are also called non—steroidal anti-inflammatory drugs (NSAIDs), or
`sometimes just 'anti-inflammatories'. Ibuprofen is used to treat painful conditions such as arthritis, sprains and strains,
`period (menstrual) pain, migraine headaches, dental pain, and pain after surgical Operations.
`It eases pain and
`reduces inflammation. Ibuprofen can also be used to relieve cold and 'flu-Iike' symptoms including high temperature
`(fever).
`It can be taken by adults and by children over the age of 3 months.
`
`Ibuprofen works by blocking the effect of natural chemicals called cyclo-oxygenase (COX) enzymes. These enzymes
`help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury
`or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are
`produced, which means pain and inflammation are eased.
`
`Ibuprofen is available on prescription, and you can also buy a number of preparations which contain ibuprofen without
`a prescription at pharmacies and other retail outlets.
`
`Ibuprofen is also available as a gel which can be applied directly to your skin to help relieve muscle and joint pain -
`there is more information about this in a separate medicine leaflet called Ibuprofen gel for pain relief.
`
`Before taking ibuprofen
`
`Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if
`extra care is taken. For these reasons, before you start taking ibuprofen,
`it is important that your doctor, dentist, or
`pharmacist knows:
`
`https://palient.info/medicine/ibuprofen-for—pain-and-inflammation—brufen-calprofen-nurofen
`
`1/6
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`

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`INDEX NO. 501276/2015
`FILED: KINGS COUNTY CLERK 07/07/2017 11:09 AM
`INDEX NO- 501276/2015
`FILED: KINGS COUNTY CLERK 07m2017 11:09 AM '
`
`
`
`
`
`NYE/éEgWDOC . NO . 24
`Ibuprofen: Uses, interactions. and side effects — Medical News Todfiywlc dIIVflD \IYSCEF: 07 / 07 /2 0 17
`NYSCEF DOC. NO. 24
`RECEIVED NYSCEF: 07/07/2017
`
`NEWS
`
`< Knowledge center
`(/knowledge-center)
`
`(/)
`
`Pain /Anesthetics (/categories/pain)
`
`Pharmacy / Pharmacist (/categories/pharmacy)
`
`Headache / Migraine (/categories/headache-migraine)
`
`Arthritis / Rheumatology (leategories/arthritis)
`
`Ibuprofen: Uses, interactions, and side effects
`
`Written by Christian Nordqvist
`Reviewed by Alan Carter, PharmD
`
`Last updated: Wed 21 June 2017
`
`Ibuprofen is commonly used to relieve the symptoms of arthritis, fever, and
`
`menstrual and other types of pain.
`
`It is a non-steroidal anti—inflammator
`
`clru
`
`articles 179211. h
`
`(NSAID).
`
`It also has an antiplatelet effect, which means it protects from blood clots, but to a lesser degree than
`
`aspirin (larticlesi16'l25543hpj.
`
`The World Health Organization (WHO) includes ibuprofen in a list of the minimum medical needs
`
`htt eri’refbooksmsforc i’msf clocslenfessential dr
`
`
`
`
`
`uc sited en. d for a basic healthcare system known as
`
`its "Essential Drugs List."
`
`Ibuprofen brand names include Brufen, Calprofen, Genpril, lbu, Midol, Nuprin, Cuprofen, Nurofen, Advil,
`
`and Motrin, among others.
`
`When buying medication at a pharmacy, the packaging will state whether a product contains ibuprofen.
`
`Contents of this article:
`
`1. How does it work?
`
`
`2. Uses
`
`3. How to take it
`
`4. Risks cautions and interactions
`
`http://www.medicaInewstoday.com/articles/161071.php
`
`1/7
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`

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`INDEX NO. 501276/2015
`FILED: KINGS COUNTY CLERK 07/07/2017 11:09 AM
`INDEX NO- 501276/2015
`FILED: KINGS COUNTY CLERK 07m2017 11:09 .
`l
`
`
`
`
`NYé/élggflDOC
`NO
`24
`Ibuprofen: Uses. interactions, and side effects — Medical News Todgfic sIVsD \iYSCEF: 07 / 07 /2 0 l7
`NYSCEF DOC. NO. 24
`RECEIVED NYSCEF: 07/07/2017
`5.
`Ibuprofen and children
`
`
`
`Fast facts on ibuprofen
`
`Here are some key points about ibuprofen. More detail is in the main article.
`
`-
`
`-
`
`Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID).
`
`It is widely used to relieve symptoms of pain, fever [farticlesr168266php), and inflammation
`
`llarticlesr’248423phpl.
`
`- People with heart problems, stroke ifarticlesf7624phpl, or peptic ulcers [farticlesr’9273phgl should
`
`use it with care.
`
`-
`
`.
`
`It should not be used in the last 3 months of pregnancy.
`
`It is considered a non—addictive alternative to opioid painkillers.
`
`How does it work?
`
`Ibuprofen is an NSAID, a type of medication with
`
`analgesic, antipyretic (fever-reducing), and, in
`
`higher doses, anti-inflammatory effects.
`
`or stupor.
`
`A non—steroidal drug is not a steroid. Steroids
`
`often have similar effects, but long-term use can
`
`cause severe adverse effects. Most NSAIDs are
`
`non-narcotic, so they do not cause insensibility
`
`Ibuprofen is an NSAlD that is widely available and reduces swelling,
`inflammation, and pain
`
`Ibuprofen, aspirin, and naproxen are all well-known NSAle, partly because they are available over the
`
`counter (OTC) from pharmacies.
`
`Ibuprofen works by blocking the production of prostaglandins, substances that the body releases in
`
`response to illness and injury.
`
`Prostaglandins cause pain and swelling, or inflammation. They are released in the brain, and they can
`
`also cause fever.
`
`http://www.medicaInewstoday.com/articles/161071.php
`
`2/7
`
`

`

`INDEX NO. 501276/2015
`FILED: KINGS COUNTY CLERK 07/07/2017 11:09 AM
`'
`INDEX NO- 501276/2015
`FILED: KINGS COUNTY CLERK 07m2017 11:09 .
`I
`
`
`
`
`
`NY§@§§17DOC . NO . 24
`Ibuprofen: Uses. interactions. and side effects - Medical News ToQaEC 4,374.13 \TYSCEF: 07 / 07 /2 0 17
`NYSCEF DOC. NO. 24
`RECEIVED NYSCEF: 07/07/2017
`
`lbuprofen's painkilling effects begin soon after taking a dose. The anti-inflammatory effects can take
`
`longer, sometimes several weeks.
`
`Uses
`
`Ibuprofen is available as gels, sprays, tablets or mousses, and it is used to relieve a variety of symptoms.
`
`These include:
`
`I fever
`
`I
`
`inflammation
`
`I headache {farticlestBQBfighgj
`
`I toothache
`
`arthritis
`
`I back ai
`
`articesf’l72943. h
`
`I arthritis [farticles-fi7621ghpj, including juvenile
`
`I menstrual main
`
`I minor injuries
`
`The short term use of ibuprofen can help to resolve headaches.
`
`For a headache, usage is short term. For anti-inflammatory effects related to chronic conditions, such as
`
`arthritis, long-term use is necessary.
`
`Some medications, such as decongestants, have ibuprofen added, to create, for example, a combined
`
`cold or flu [£articlesf15107phpl remedy.
`
`How to take it
`
`Ibuprofen is available in tablet form, in syrups, and as an intravenous (IV) preparation.
`
`Dosage de ends on htt sn’r’wwwdru 5 co
`
`osa e ibu r0 enhtml
`
`the reason for taking ibuprofen and
`
`the age of the user.
`
`For adults using it for rheumatoid or osteoarthritis, the dosage is 1,200 milligrams (mg) to 3,200 mg orally
`
`per day in divided doses.
`
`The patient must be monitored for adverse effects, and the dose should be adjusted so that the patient
`
`takes the smallest possible amount to meet their treatment goals.
`
`The usual adult dose for pain is 200 mg to 400 mg by mouth, every 4 to 6 hours, or 400 to 800 mg IV
`
`every 6 hours as needed. The maximum dose in one day is 3,200 mg.
`
`http://www.medicaInewstoday.com/articles/161071.php
`
`3/7
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