John Langdoc, SBN 235509
`Denyse Clancy, SBN 255276
`Eric Policastro, SBN 264605
`BARON & BUDD, P.C.
`3102 Oak Lawn Ave., Suite 1100
`Dallas, TX 72519
`214/521-3605, fax: 214/520-1181
`jlangdoc@baronbudd.com
`
`Attomeys for Plaintiff
`
`ELECTRONICALLY
`FILED
`Superior Court of California,
`County of San Francisco
`JUN 07 2011
`Clerk of the Court
`BY: JUDITH NUNEZ
`Deputy Clerk
`
`SUPERIOR COURT OF THE STATE OF CALIFORNIA
`
`COUNTY OF SAN FRANCISCO - COURT OF UNLIMITED JURISDICTION
`
`
`
`EXHIBITS22 TO 30 TO THE
`
`DECLARATION OF ERIC POLICASTRO
`IN SUPPORT OF PLAINTIFFS’ MOTION
`IN OPPOSITION TO DEFENDANT’S
`MOTIONIN LIMINE NO. 1 TO
`
`PRECLUDE EVIDENCE THAT “EVERY
`EXPOSURE,” “ANY EXPOSURE,” OR
`“ANY SPECIAL EXPOSURE”
`SUBSTANTIALLY CONTRIBUTED TO
`DECEDENT’S DISEASE
`
`[MIL NO.1]
`
`Dept. 220
`Hen. Harold E. Kahn
`
`DewmNWDRwhFBBeYe
`BOBeBOBDOBRODBDOReteoo~sDHWwFSWeHNKHCOCOOoHSOOrRUBUD
`
`MARBETHHOFF, Individually and
`as Successor-In-Interest to RONALD
`HOFF, Deceased
`
`Plaintiff,
`
`V5.
`
`BONDEX INTERNATIONAL,INC.,
`et al.
`
`Defendants.
`
`
`
`Namen”net!”ne!ne”nee!te”Ne!et”Sa”etetlet!etetlgeet!et!angeetgtget Case No.: CGC-09-275113
`
`
`
`Complaint Filed: March 12, 2009
`Trial Date:
`June 6, 2011
`
`
`"EXHIBITS22 TO30TO THEDECLARATIONOFERICPOLICASTRO IN SUPPORTOFPLAINTIFF'S.
`OPPOSITION TO DEFENDANT’S MOTION IN LEMINE I
`
`

`

`~ Exhibit 22
`
`

`

`
`
`

`

`ie Farbiiesdiion: Ofhse IsLaradioned Lintonagains Danae
`Tat £ Cancer 54, 574-581 (1999)
`
`Pubibesdinny BerAieaitearore9 antrebo Pang
`1008 Wiley-Liss, Ine,
`MALIGNANTMESOTHELIOMAAFTER ENVIRONMENTAL EXPOSURE TO
`BLUE ASBESTOS
`Janjc: Hansen, Nicholas POR LER?JanL. Eris A.WilliamMust! and Mdishae} §.T_Howes?
`IDepartmentoffRetpintdiryIdedticine, Sir Charles GpirdnerHogpital, Verdan Street Nedlands, Westershuenalit6009- aid
`‘Departneni ofPublic Heals, Uetieay ofWerte.durinclia, Madlomds, Wes dunialia,
`
`
`
`
`
`Fabracorteeed
`
`1
`
`To detarmins the magnitude of the population at rial inom
`PeRoccinaticnal expanse io orcdodite at Wittenoom, West
`am fustralia (4A), a cohert of 4,000 residents whe reaver
`worked far eine eencompany Avttrallan Bla Aghios
`(ABA) kas been
`ed Gren all 16,553 avaiable, meceads:
`tbe Joes] school register, hospatad attendances, che WE electoral
`Jed, birBi certifi wrortgegssYefea aneanited areaRod gesting
`
`orttyof subjects: were relmtivespad fiendsof ABA
`ces, aretnnariyFaltha colfortware either arn asWeehwrtooee
`er first wert there as children under |) pears of azo. Ac most:
`recikdoats were at Wittencom when the mine and mil wane in
`operation Wurlig die period Hdd te 1956, G6 were firsc
`eopeed ba creedeite 20 ar mare
`aga, The ProporGerof
`other workers Gc, not ormplopedbeyby ANA) and hear tomes
`mtreacod onoethe miniag cperathns cessed, To cyte, 24 cases
`of iteedhelions hark: been haported in this calert: # males and
`[5 fepreabes, Tepe fron Seek expestire to dinpmosis ranged front
`235 tc 44 pears aod resldesice BiWikio ranged Dre b weeks
`bed yesa
`BMG Wilyedts, die
`
`
`artespbbereenefeeenamiRomeresmammabhiimcreaccfDatncabeaaccebeRRSeeeb
`.:.1..”...
`*
`..
`
`
`.'1..*
`
`
`
`
`who over dived or worked ia Wittenpom since [43, inorder
`
`‘and FOS
`ton, 197) and
`rani emontrations aE
`anh
`arerefomad.) aa
`ETH:
`Thepnpof isytrota eofpoopie
`» detesninthepopulationatriekFrectvonecupatonaloxcto.
`6 residents iedudta pee whe wore in
`dolite cxporiee
`fewer as Telatives ofworkers, espectallr tives ard chil
`andple
`who worked for other mining companizs
`asporectinionkeoxployees, such ax teachers, hospitalstaf
`ea inenooan as 4 base canip for exploration ofthe
`area; people wha wer scliemplayed; and tim *
`.Bacluded from this Yst are thos: prone
`Ion te have worked fer the Austvalien Blue Ashestor
`company in tho mining and milling of crocidoiite,
`-
`ihde
`Study oFtheepesineants bfWattsmoom will makeit
`ely of
`to etHimate the cfents on health of
`seatedetaeeis higherokra ceporore ih Ska
`tehted
`ia
`Lg
`expeore iz first
`eqpegenoed im
`obitdhood. This cohort fa wolque: it Is the onlysnch group of
`peoplein thework who hays boca exposed te defined Lea
`of crocidgiie and whe hava Led lithe
`iorsa
`oEpasuna bo other forms af ashestes sewhere.
`pee
`by the.Winenoom residents ae similar
`in mepentude eo those which ney comentoccur ta Aistatag
`Warklaces under recent legislation The infeomation ch
`Gon Hisgroup will beip to Ol 4 darge Be
`in the
`Df erockalite
`Boovedee of the Gopcresponst relationships’ of
`| malignant disease at tha lower levels‘of the expomuye
`TaOge.
`
`.
`
`In arldition to whestos-related disnase 10 people empoced in
`an Oecupational setting, exces tales of malimrent mesotheli-
`oma aid asbestosis and postibry lune cance, bare cecurred In
`people éaposed £0 asbestos torough boasebold contact ortth
`ent, Ehoough neighbourhood exposure to avhesbes mines"
`bod facnodes, and throagh cainrel anaconmenial exposare
`(DeKlerk aad Arrastreng, 19923.
`Crocidolite (live acheshos) wag rolied at Wittenoown Ghoree,
`SUBECH ASD METHODS
`Weeter: Australas, by ihe Australian Hos Ashertos Company
`Information on retidents wis obtaiged from, momerous
`(ABA) Detwcen LA and TS. From employment recor
`bold by the parent company, CSR Fad, information held ai the
`coerecs (rable Ab: Beeords were collected foam the Stete
`pol in Wittonoom, which wax open betwern 156
`Pera Chet Clinic (which hes bern responsible for the
`ened 1879,yanpoidsInfaresationabouteachpupalguard
`siniuigg: pexkedic Bovey examination of 2ll workers in the
`dan a3 well ao
`Adbelstim and oot-patent records
`malting indagtty im the Staie), and the records of a benevolent
`from: the Wittnonm Hospital from 143
`if closare in
`fund bo which all Wittencoin miners conoibuied watil 1956, i
`1979 included particular of tha
`patient anadhisfher ect aff
`hasheen cotabished that during the 23 pears of is operation
`kin, The State Electoral oll forthe Pilbara Electotal Diener,
`aboot OG wedkers were emphyyed by ABA. Excess mortality
`from 38 bo 1589 tecorded deteof
`ation as well as
`dion, pitomedaniosiz, mallgaant mesothelioma and-respina-
`and 1961 were”
`Midtess. Tho’ Sate Etcctarel Rolls for 1
`tory cancers has been experienced by these wockors, mtd has
`ared with the corresponding
`Commonwealth Electoral
`been depeadent both on tine Mos ficet eapomure bo rrmacidolite
`for the Pifiare subdivisionofthe division of Kalenontie.
`ard ont total cLnnulabive crocidlite expoeure (Arusorong etal,
`No additional records were found, ald the Cocomodratalts
`1985). Busessooctalibyhes ated been experepend from tber-
`Electoral Rolls for the remaining years were therefore pot
`"gnosis,accidents and smoking. aid alechol-related diseaser,
`atexched Infomadon aboot relainves andfends was supplied
`to crotidodite of thoes residents of the township of
`by approxioately 2500 of tuemutkers in 1979,when theywere
`aaqvedtonpeireon :
`Wittenoom who were not dirgotlhy esupleyed fr the croeddetite.
`contactedbymad] or pom andaca
`iInchwWed acurrant addvess, am] tievital.informationscpplied .
`theit pein of Work at Witter
`fadasty goouned fom gemécal envircumnestal contamination
`from the milling oporalicas and freeg ‘the apt of tailings row
`she mili for Hie peving. of roads, driveways, carparks and
`of fiend, Details wore obbidaed hor thé cocgnds kept bp the
`
`achoolplaygrowads, ip the yards tfhoupes bo suppress fust and
`redine: tyddiners, on the tace-course, end fram Household
`7To whom eormeaponitenan aad sprint reqeeans,short fee act
`goatee with, the worktas themetives and oath thelr clothes
`dressed. Far (09) SASo4B
`..
`'
`v
`(Musk «tof, 1993). Baviroonectal studies of the tevaship of
`Withtnoanrwere conducted by theWeetern Acsralian Gera .
`ment Public Feakh Depertnent in 1978 (Cumpeton, 1978)
`
`
`
`Receiedk Sancacy 4, 1953.
`
`

`

`
`
`.
`‘
`
`.
`
`'
`
`-
`
`. “Wittepootn anediesl setands 143-59 FSO iden (anses
`WA electoral rail 1443
`S264 (13.0
`2550. HG &
`Loeval school resords18-45-1970
`Workers’
`questingesines 197°
`1973707 (14.5
`Birth certifients revonds 142-1972
`18 138 G8
`Vitus£programeandamactzied Te 4a 7.25)
`BOLE
`. BBL a2244)
`ae
`
`Total
`"155534590
`
`Family
`
`,
`
`.
`
`-
`
`a9
`
`554
`205
`“200
`WZ
`447
`11
`
`.
`
`:
`
`.
`
`.
`
`;
`‘MESOTHELIOMA:ANTHENWIRONMEMEAL ASBESTOS
`“TALE 2oURES GERPORMATION
`sir
`Son
`TABLED) — FERCENTAGE DMTRDBIIOION OF
`cn
`7 _GRMGR,
`AFR COARACTHRESTICS
`“Some of
`oe
`-
`Suber
`-
`riprecengy ate mate]
`soe
`obgding "diBierestiog
`Chorals
`\ ee
`
`gmap
`aires ofABA cnphoyens.
`Other workers
`Relatives of othes workers
`Geese
`Male
`Fema
`Unkoown
`Relatioastips
`2045
`Boplozed at Wittenoom
`iCatholicChurch, AshestosDiseasesSocietyofWA,¢Guepaticn
`ape
`,
`241
`paleheepital ete, Sowa EL
`clinica at SOG, Bortabretonde,
`Lormacant
`ddeen,
`501
`Relatives
`44
`Read
`He
`‘Year offirst residence at Wittencom
`1945-1946
`BA
`tal practioner in Wittenoom, from.
`poGes
`records antl
`1556194790
`Aa
`burial resonds, A Bouse cemous of resi
`IsntGieag
`42.1
`was Gudertakenfo 1979,
`PolesDemetmee from
`WAH
`a
`the Efpeetion Deparinént,
`the Heal:
`ASR007
`1a
`Deparment of WA, aod fron the SWittemoom Hotel The
`nkosi
`aa
`At Gest residemes at Wittenoorg
`. Catholic Choreh provided a Hst of bapcisms peop, and of
`There
`a2
`fests and ister who Msited 40 Wittenoom. Hirth retards
`203
`aa
`the Rosboume andPort Hedland districts betroon [HP
`at
`13.6
`and aaaee al the RepistrarGenerals Qffiteip,Herth,wete
`1-19
`a3
`searched.AQreeords comtainiag Witteman 2 the usual piace
`a027
`iit
`* alresdence, or the place ofbirth, were extracted
`aa
`a1
`Tn 1989, all workers whose whereabouts ye keane were
`ue
`25
`S59
`15
`ocuitarted and invited to participate in a cancer-preventlon
`Ie wih
`a
`PTOETicene, using Wiamin A. A publiciiy campaign sinsed ar
`Valkiran
`10.8
`collecting more information do redidenis was lousched to
`Length of stay at Wittenoom
`cede Fi the ccmmenccnent OF the vituninA Pro-
`162
`<l year
`gramme.
`-pcople joining the
`prendde
`JeBorbton, onrelatives cond feds who had been at Witte
`366
`1-3 yoare
`3.4oom
`14.0
`the Asbeskns
`‘mom. Ctler-ioformation fas been provided by
`3-9 Fours
`1k
`
`Digewune Society andbpqutpatient clinics at the Sir Charter
`> lOyt
`a]
`Gairdner Hospital ¢
`5
`Galatians
`ik
`Age: ofeobjacte al
`The cobort was hen asenthled by merging all the recdads
`30
`1é
`cdlierted from the various sconces and creatiog single record
`20
`13,7
`fox cach person, Decails inchided fall came, iocoding
`previous
`ay
`Ba
`RALLeE,
`of bith, coment addres, te of rect
`in
`4
`16.8
`. “Witteneam and details of say cnpkymend while resdeni in
`Sg)
`Ths
`Dl
`a6
`Wittenoom.
`.
`om
`ao
`Records of all cases ofmalignant mesntheliqna in Western
`oo
`Univers '
`155
`“Abstralia are systematically registered bythe Westem Austea-
`Ths sings first residence at WitLenoann?
`lan Mesothclionma Eepsty. The Australisn Mesothelioms
`
`Prahon 4
`yeas
`35.9
`Sorvelilane: Programme b nodibed ofpossible cases ooeutring
`SCH cary
`37 2
`erent Australia.Thesewere used 16 obtain canes ardciaz
`» dD years
`a9
`1
`eobort.
`.
`:
`7
`.
`24
`
`
`~SRrearmeref—aaer
`Ppeg
`
`.
`
`Age et desth if swhject is known to he dead—Time from first °
`remdence te death if tic subject is dead_
`
`.
`RESULTS
`.
`. A TON) ef 18553records bus been collected, yemtting in
`S017 iviividuals being identified. One hundied and cwenby
`ated oocuparicn being tutknet" oe te corsleves edi Cane
`Ghiléren verter 10 years of age and most (50.9%) stayed thene
`fow legs then 3 years. Most mesidents first went to Wittengom
`dialed
`occupation heme “obser” other empl
`CSR
`8? men-and -
`ty ABA, leaving 2 pobort of 4890, comprising
`hes the mine and mill were in
`trom. during: he perio
`“2703 woress (table IQ. The
`bigh
`pesembige of wonen
`143 “to 1986, and conseqmently $1,995 were first expased to
`. 4255) contrasts with only 5.99%
`females inthe. workers’
`croidoline 20-07 ntat years agn.
`cohort (Arnstrenget of, 1988), Table 1 also shows the nantber
`population while
`_ The bern of Witteiocsn hed im greater
`of tetords cbiained irom the WaioUs. sommes ned fy asaemn-
`
`he aune and mill were in operation, althoughtheproportion
`bilathe cohort,schol and hospital records proving the most
`of athes workers’ fie, nol am
`a by ABA} and thedr
`Tee
`hal.
`ms inirrased ones the oriningoperations ceased (Table
`‘The majorityof subjarts (45.5%) were relatives and Crinnds
`. BEATA,
`I
`most beiog
`spouses or chiitiren
`(TableJ).
`‘The aanjority of people
`loyed at Wattencom, but oot
`“Rearty InoFthenoon’ a3.)wore fist at Bae a5
`dinestlyinvelyed in the ccd dite industry, worked for varigns
`
`
`
`

`

`ist
`
`depaninents
`.
`'
`
`aes
`
`HANSEN ETAL.
`ma.
`Ag
`:
`ARLE—FEROUNT,DASTRIENTIONGFSURIECTSBY DRCADE OF
`BRCUION
`-
`an
`ay
`[tiebetieved that the cohortassenbled ip Conylishr, Cogpar-
`Chaewiesieie
`yk thay eaa Oem) a=HB faeeen
`ison batbvenn this group of peaple and the population of
`Witteneom (hayinant, UNE) at vacious reorus datep sherr chee |
`Faruilygroup
`:
`ABA Toktives 743" * 4 65.1 Wd Wt
`comapondence. Lack of completencss wood be unlikely to
`Orhers
`Le we
`44
`oo8 wa
`introdnce anybis into the plannedretrospective lenzitodinal
`Gender
`.
`.
`:
`sohort study, bees missiag recor showkd be unrelated
`
`
`Male did=305 Pad 4512 4
`
`both br expaniure and to the moidence of mesothelioma.
`*
`610°
`=
`aa,6
`sna
`ae
`a7
`Relawonsht
`*
`“it has been well extublished that the risk of mesotheboua
`inereasey epi
`lore st
`9p
`139 asada
`with thos since filme expowre to
`crocddelite
`Hlerk et cf, 19600), with mo cance
`bai
`2a
`52
`reported fa Wittenoam workers within if-yeass of Gest cp: .
`47.
`sire (De! Klerk at of, 19958). The mafosty of this Patent
`cobertof fcsvsidents oF WittenosmM4smocnbled LS}
`
`were
`firsk expe:
`to -K) yraze ago,
`Potentially ony ;
`taned pf mestthelioma are yet ip develop, especiathy as LL ef
`the 24 cose havebuondiagnosedin thelari4 years,
`
`The ambien Jere! af aibesks Gbres amumd Witenonn,
`when He mine wasoper po en iar a 0.5
`16g
`151
`Goverupant
`Shes] (soométvong sf af, 198%}, and
`the levels
`airhenmns
`113
`ie
`Edining
`forcemeasured in1978 and 1979Tanged from 0.01 dbres/md
`Ine
`1
`Stations
`521 Sbresfal {Cumpston, 1978, 1979). However, no indoor
`AA
`bd
`Tote datics
`G2
`B2
`FostroracHotel
`levels of caocidalite fibres have been meatumed, These levels
`Es]
`BOSpOKE
`fall he coumpared with dhe orposine Jevelsofbetween 1 e150
`a3
`3a
`Buildingindaxtry
`fibresol
`d by the ADA. workers (Armetcony etal,
`ag
`FJ
`Ganral labouring
`1988), and the backgroundievels dsewherminWestern Ansa-
`3
`3
`Wontwihashestoa
`Hs, which are noch Jower (lé¢ than (002 fres/ml)
`(WAACALS, $900) A recone sudy ofan ashe
`a
`22
`na
`Shice{Connell
`birth cobort Living acrenda SouthAfri ommotdoliic onne ft
`i3
`9
`Sclfanployed
`ai
`the acvironnentallevel of exocidohita fibres to
`45
`15
`be iatheradge QUMG2 be QO00T fibresim, However, there
`Fites
`it
`14
`Wire No InSssOPEMENmadewhen thecrocidolite minewasin,
`Fin
`ag
`ste -
`operation some A yeory earlier. The study was. uneble to:
`determing the iidensity rad the duration of
`we for
`‘Other employees
`40
`5.)
`wenbess ofthe oohuet (Reid ef af, ida),
`R hes
`Vnspectiied
`iay
`Ba
`©
`bene pacestary Jor entimaies of rhe riskofmesothelioma cue
`Total
`iwa
`One
`ie low levels of exposme to urpcidolite to ba mate by
`$Suibjecia employed by ABA ectuded,
`extrapelating backwards from dete obtained from oconpa-
`Comal otucties where fibre concentrations wees typically 1tw
`100,000 fines Ingher than usual peoeral evingnmental omen
`the sta-
`grvermment departments, other miniag companies,
`aliens (CGardnsr and Saraced, 1909; De Klerk andArmetrinp,
`tons soxrmrndiag
`the Witatoom iowaechip o¢ the Fortescub
`1902)
`,
`Hotel (Tale
`TV}.Among these working for ihe fevercament,
`4035 new lotended to-estublish the vitel stagus andthe coded“
`the most commun occupations Were Twith the Department of
`canst of death of all wubjects ta this cchort, These will be
`Cant Aviation (22),
`the Education Department (27),
`the
`asrertaioed bystarching all available xeoords. AM information
`Health Department (21) ant the Folite Bopartmsnt (71).
`on death and cancer (aalizoaat mesothelioma in particular),
`Taenythres subjects worked with omecide
`ak were
`wall be senghl, a8 in the werktorce erudy. For each person in
`metaly invalyed in tra
`ing
`the crocidolite Frum. Wrtte-
`this study, an index of exposurewill be calculated, basedon tke
`noon bo Point Sagem or
`di for caport (Table Tv}.
`duration of
`gad the coucedtration of airborne flrcg
`‘To date, 24 cases ofmalignant mesovhelicaue we known bo
`3Wittepoom, The rel
`is bitweom sxposure and risk of
`bave oomoread in thi pohort (Table ¥) Of the 13 known
`death amd Giogasewilbeestimated. Levels azsi curation DE *
`famale and 9 Koown male cases
`thoupheta heve arisen because
`cpaeelane: Heed,
`a,
`peice
`ration
`oferviconmental exposure, 9 cases have occurred in wives and
`shiain this stindywit! conesranges of datined-trposrebelkew
`D rases in children of ABA worker, 5 in other workers, aud j
`ip a ralative of other workor. Freteoa Of cepomirdsomged
`aay previously sonducted, and the iacddenca of ashextos.
`related disegea at hogIevtlecot be decribed,Gavan the lage
`from6 weeks to 1 years; ope al first residence
`bith to52
`yeors; time fit first cepidecice to death from 24 in 44 years,
`member nf worten da the aphort, the study will wkte be able to
`. 2ontTheNe amebismange from3fewciao
`enamine the possible link between asheshoa and ovarian rancer
`46 months The doration of time dpe by weabers of
`this
`(Diol sndPeto, 1987). -
`“
`cabtct af Wittenetnn daaged from 1 mone t41 pears,
`-
`Because throrformer residents ofWittcnoom hitg bean
`+
`they cases ofmalignant pleural usesothalicna repoed a
`“posedto levels ofcrocidolile intermediate beberen the high
`th: Mesothelioma Registry concern
`who dain be Jee
`Oompational levets of the pest and the-kerw envirostveatal
`fived at Wittenoge forvarying
`of time. They Hove nor
`ievels of today, this study will allow more ronfident extrapola-
`been “meindedin ibis report because fq were anak: fn
`ten from the dtporureresponse celationships established to.
`mep
`cshabligh, by the methodk desevibed, that they
`eathmete the risks of mesothelioma fa cther eyviroomentally ©
`had lived.at Wittentoam,
`.
`.
`Grpoded subjects,
`-
`:
`_-
`:
`
`ectsrreriwetbansbaaabieer
`
`
`
`:
`
`”
`
`.
`
`-
`
`
`
`

`

`oa
`
`‘
`: ao
`2 TO
`
`:
`
`
`
`-
`
`.
`
`.
`
`.
`
`a
`_.
`“ .
`
`MESOTHELIOMA AND ERVIRONMENTALaSMesis
`TASLEY~CARESERTASOFMESOTHELIOMAAMONGHITTENOOMRESIDENTS
`.-
`-
`” Brett
`yy
`-
`:
`=
`-
`middener
`a
`.
`Dhesipliga
`otf
`eer
`- ae
`ad
`.
`> Suonal fon
`--
`-
`_
`"pee MEREUGE”
`fine)
`my
`baaie
`3s
`E
`iw
`AthABA, worker, rasident for 3 months sone mee 25
`now-ATAworkey, reailantfor B yearsfron ane 3
`ar
`<1
`ind fenstWattenocan,zesidedtfor7years,son ofAA
`et
`6
`. &
`ehid born at Wittenoon,residentfor3yoars,smeofABA,
`ae Mi
`a
`- 58 3-3nonABAworker, residentforyeast from age 19
`§e
`a.
`Pa,
`DonABAtoner, residentforyearsfrom age a3.
`-
`|
`
`
`
`dis 4 SononodEAworker, residentforthyearsfromage23 19 ct
`
`AQ
`et
`-
`gl
`child,resident ZorSyearsdhomageSamonthe,sowne
`.
`:
`!
`sm
`oo
`PhoneABBAworker, residentfar 6weeksfromage42
`.
`t
`,
`.
`.
`-. Sal.
`41°
`Fy
`wift-ofABAvantker,Tesidend for 6yarns irony ape4
`
`
`
`
`
`
`. sa CRekMather,Residentfor6*frouage23 .x ih mo, oo |
`.
`hid reddeato
`ty
`ier
`oLABA worker
`-
`335fiomafr diaea4° ehild cegdcmtity5pens
`
`
`
`wacker
`-
`~
`,
`41
`24
`2 ehild resident for3 years Grom ego 20, danghtec ofABA .
`|
`a3
`a4
`G
`withofABA,uthes,Tascafotamcntiafracnape
`
`
`
`
`‘ child resideat wage5years,39 ad é daughterakABAworker
`44
`%
`a
`Wife afABAworker,residentfor12 yeatsftom age 41
`a3!
`at
`i
`.
`Pilie ofABAorher, residentfor 6years from age2h
`sa
`Ww
`4
`wiiofABAworken, resent foSears from ape 2%
`ét
`36
`0
`wilecfABAworker, peddentfori
`Erasn age23
`‘ao
`4
`19
`child resiiient for 7yearsfromaps
`igughterofABA,
`.
` prorker
`»
`FF
`aI . chiksesident foe 4 yearsbomage &, daughter ofABA
`Lo
`
`3B yearsfromape2on 11 velitofABAworites, residentfor10
`
`
`'
`fy
`4
`.
`4
`witsofABAworker,cosidentfoc] vaacfrom aeith
`4
`5
`-
`1
`.
`,
`=
`‘SHO plivedd ofBlDecember1993,
`.
`.
`
`
`
`.
`
`retondsin 1979, endtheractiTagementofDr.J.hdiedaly
`;
`ACKNORLENDCEMEDTS
`us
`.
`t
`
`
`
`[ ‘This stody was fundedbytheSate GovernmentInsurance« fromwhat was the Poblic Health Department of Western
`ex
`tment of WestentAura through the Six Charles Australia. We ats:elsograteful to Mis, L Stith anf Me, B,
`_
`Geirdacr Hocpitet Research Foundation. fk would not have Woodtotfe fy agsistance im date cofeetion, and shembers af -
`i
`been
`Without the considerable efforts ofDJ. Beker
`the Astestoa Diseeses Society of We, (Ine) fev their a
`“snd
`+ 8Woadward in collecting many of the initial paper
`oparaden.
`.,
`i
`,
`,
`.
`-
`REFERENCES
`"ARTS, BC,OekuomeSEL, Mux, AW. andHoare, MT,
`Thou, F. and Pero, J, Other asbestoereJatedneaplaams, far K,
`
`
`ddoetaliey amc milters of onocidotiteinTW: er Artin Anigtin (ede. Amatorreined malignancy,pp.$1to miners ann J. Aigner
`
`
`Breepee45-13GME)
`GruneandStraten, OnanTar.
`cans
`Bp a
`|
`
`$ eponaetatboreemavenfonsWkeeeeaeNOcatia28,pp.DepuctmentefWeateenAnatolChee
`
`Cu
`AG, The heel mma af Fiona Poblic Health
`ALJ.ad Sapaccy, B.,
`on beech
`oan
`|
`-CUNT, AGL,Reyne to erecidalite Wicuwsom PubtieHeah
`3
`LARCtonCo),
`
`i Lavan,JL, WerkandfaFaoeNieto,TE43-1566.Deparmentof WestersAunralS(1972), *
`
`
`t
`Dn
`RELondArormaio,AE,The
`saniokogyofwaht
`Commursity
`HiraltnStudies,7,148
`(1963
`.
`,
`ad Se eePeteyMiles ete B es, proneBEeeasNGieeeae
`3
`aq
`.
`In
`FTRONG,
`LAT,
`au
`at,
`i;
`t
`Heshtaphere, NeYuckea
`ep
`Auanticamodernindustrialdiastbr,nic.FfolMeet,24,TEU?
`De Rupr, NOM, AmmsTaovG, BL, Musk, AW, andHons MST,
`:
`mot
`‘Cancer 1
`it
`eefatindy te Grbocholiee a. Witteacom Gores in
`Rao, G., Kinstowen, D.Greve,SDandBora,K, Mortalityof21
`&
`WesternAustralis. AnifotMad 46,52-535 (HD),
`"agracxpased Birth. Ghar? @ pilok atocly, South AR, ied 3, FR,
`DORR, BLAL,
`ARRITROHG BLE, Muse, AW, andBoens, MSF,
` 3H-58d (199i,
`.
`"
`LAL,
`Prodistloes offutirg pases of asbestos-related diacasn que mooeT|=WESTERN ALETRALIAN ADVISORY ‘Copiatges ON HAZARDOUS Ste
`30
`Asherar comet prodocs, Eoakh Department of Western
`.
`TEs and pillers ofcrocidobia ia Weslerh AustraliaedFE dus,
`Austral,Bort (19804.
`151, (16-920 (19855),
`.
`
`
`
`

`

`Exhibit 23
`
`

`

`
`
`FAN15151(OFWe (LO)NU
`eye
`INDUSTRIAL MEDICINE |
`
`wake fp Hee
`
`Ruth Lilie
`
`isDuane EXVIROXKMENTAL AND OCCUPATIONAL
`Ss TUmatcastsie cache Toe
`
` “gir,COUNTHANE Editor-in-Chief
`‘araeea Philip J. Landrigan
`
`Ptee Deputy Editor
`
`
`
`Advisory Editors
`prin eakeeanecnRela Bingham
`Kenneth Olden
`Richard J. Jackson
`David F Rall
`J. Donald Millar
`Linda Rosenstock
`
`a
`of
`
`Associate Editors
`Henry A. Anderson
`Steven B. Maxkowitz
`Shunichi Araki
`James MM. Melius
`Dean Baker
`James A. Merchant
`Albert Miller
`Pateicia Buifler
`Willian J. Nicholeoo
`’ Axrthoor L. Frank.
`John M. Peters
`John RK. Froines
`* William N. Rom
`Malcolm J. Harrington
`£. Neil Schacter
`James EH. Godbold
`Ellen K. Silbergeld
`David G. Hoel
`Yasnnosnke Suzi
`Howard MM. Bapen
`David H. Wegman
`Atosley Weston
`Mary 8. Wolff
`
`Stephen MM. Levin
`Richard E. Letz
`
` Assistant Editor
`Y pWeee
`
`Marise Burger
`
`

`

`AMBRICAM JOURNAL OF INDUSTRIAL MECHINE 20:252-266 [1 56}
`
`oe
`
`Chrysotile Asbestos ts
`the Main Cause of Pleural Mesothelioma
`aaRT
`
`Allan H. Smith, 4p, phd, and Catherine C. Wight, MPH
`
`Jn cantrast 10 amphiboleyorna ofasbestos, chrysotile asbastos f offer clatiaed to be only a
`minor cause of malignant pleural miesothelioner, a highly fatal concer of the fining of the
`thoracic cavity. fa fds avtiche we examine the evidemer from aciimal and urna sindtes that
`relates to thiy insve, Reported data do not meppors widely quoted views regarding the reletive
`inertness of chrysotilejibars in mesothelioma equation. Irfaci, eraminetion ofa!pertiumt
`Studley makes if clear that cheypsodile asbestos ts similar in popecy ia amphibale ashetms.
`Since asherios it the major cowie of mesothelioma, and chryrofile constlades O3%6 of all
`nabestos use world wids, it cow be concluded that chrysotile asbestos fr the natin cue of
`pleural matotheliona in PeeerigapLe.
`SIME WiteyLier Ine,
`KEY FORDS: chepsodle, exiestes, essatheliome, apidemslological studies, ayimel stand
`iex, enphibole igpedkerts, Shanti dypotiesiy
`
`
`
`-—-roof—-f
`
`Chrysotile asbestos is ceteblished he ‘be & cass of g8-
`INTRODLUCTHON
`bestosia ard lum cmneer. Tn Fact, ane: of the Highest risks of
`
`adbestn-related Janne cancer wie gheervad ie textile meant
`Azbeatos inhalation is ao astabWabed come of cancer in
`Factory where 100% chrysceile wag used (Ocrent at a,
`fumans,particularly alignand mesothelioms anddung cane
`
`£994], However, the opinion ic held by some that chrysttle
`er, This the main cause ofcancer rewlting from wodkplace
`
`asbestos is Tauch less hazerdows than stacidokite, amnsite,
`ATPOMIE to carciacgent.
`
`end Demolite, particulerly where matiguact racsolboliomm is
`Despite exrenstve cancer studies in humans, coral
`
`concemed. MoChinald el al. (1909) stale '“Aanphibole as-
`centovemics oemiain sbatt asbestos exposnre and bore
`
`bestes fibera could exphain cost mesothelioma casey in
`cancer, Theprimary anateavery 1g the qeeshions of fiber type
`
`Canada and other [narganic fibow, inchoding chryrotile,
`on causation of mesothelionta. Commercial use of asbestos
`
`very few? Wagner (199 LE tates: ‘There is overwhelming
`aeinty involves tha reo amphibole Her types, crocidalite
`
`evidence that crocidolite is the main fibre necociated with
`andanwsite, and one seqpenting Ebertype, chrysodle. How-
`
`cmesitheliomas. There ie no clear evidence that expexte
`aver, choytotie acbesios fe often centaminated with boat,
`
`te uncagtaminared chrysotile or anthophylitite 3 assaciated
`ameunts of emote, an amphibole. Gber. The key questions
`
`with these tumors.” Two reeeatatticles, however, iriwe COD”
`conten whelher or not, and to whal eaten, posure: to
`
`eluded than chrysotiie im, an fact, an niportant cage fFTg-
`Chrysotile asbesnag {incheding its natural contamingt tem-
`
`liguant mesothelloma [Eonehatek, 1994; Nicholson, and,
`olfte) causes mesothelioma in binnane, While shere is evi-
`
`Laudrigan, 1994]. Michelson and Lanvdirigan conducted a
`dence Hat sbrysedle asbestos ia neta pottnt eabse Of Te
`
`hough review of the evidence conceming de CRECLACRS
`lignan!pesitonea) mesothelioma EPA, 1986; Doll and Fem,
`
`utety of chrysotile asbestos. In particular, they nulized the
`19851, the rate oF clrysotile ia the camsation af plewcel
`
`vetiong dee dependence of mesothelioma risk bo apeertion
`mesotheloena is still disputed.
`
`the contribution of she differant exposure poviods, and THUs
`aA
`ot different fiber types, bo the observod risk. Henchartk
`
`ndldresens OTe CUTeAt contoversial issues suornding a
`
`Beher| of Public Henin, Linke at California, Berey, CA
`beets health effects and ibedr celationshap to camper risk
`Adhd: reyuted requecte 4 Alkin K. Smil, WG, Pru, Pooteccem of Egttie-
`
`aystesment and risk mopagenient Ashess artides point
`heey. Bachosl af Palle Heat, Univosteyof Gallia, Bestedey. BA Bred,
`
`ont, the question of the carcinogellic potential of chrysotile
`
`Agceptad tr poblieaiion deruary 28, 1855.
`
`8 190m Witey-Liss, Iie.
`
`

`

`
`
`Chrysotile Asbestes and Masothelioma
`
`253
`
`asbestos fe not Only of scientific interes, but also bap leoal,
`peblic policy. and public health impostace,
`The perpose of thle pager 34 w further exemine boik
`human and animal evidence concerning the imporiaice of
`eheysotile: asbestes in ceusing malignant pleural mesothe-
`Homa Specifically, we haveidentified the 25 epidemiologic
`cobort studles having the highest ruio of pleural mesothe-
`ficanee per 1,000) deaths, and have sssasied the bpeiy} of
`asbestos fiber exposure in the highest risk cohorts. We bave
`ale reviewed those lines ofavidence often otted in euppont
`ofthe theary that ampldbole aghesine, aot cheresatile, i-th
`primary, i€nat sole, cause of malignantancsiothaliona Such
`tines of evidence inchide: results ofcertain epdembolosical
`studies (Euch ag the gas mack studies, and the “Stanton”
`aud “‘smphibele"* hypotheses.
`
`A REVIEW OF THE .
`EPIDEMIOLOGICAL DATA
`
`4 review of the litersbore war undestakeg to identify
`avai: aihestos epidemiological studies, Cabout piadies
`{eros recent Follow-up available as of October 1094) were
`reviewed for dhe following data: indysiry, PEND asbestos
`axposare (he fiber hye ta whieh the cohort or subcahont
`fad Ole greatest expasera), secondary asbestos apazure (f1-
`bertypes t whieh dhe cohort or subcohort hed eser expo-
`me), amber of workers in the color, wumber of deaths,
`muroker Of bop caicer deaths, excess Jung cancer deaths,
`and nonmbert of masethelions, Pleural mesothelioma igei-
`deace within the eqhort wee detcouined in ems of dhe
`nomber of purest nvsothelome deaths por 1,000 deacha 26
`Tell ag the tatio of pleural mesotheliomas to txegas
`caacer deaths. When possible, ae mortality data for pubes
`bouts with greater than or equal to 20 years dinca start of
`employment ware wed in detenmiking mesotkeHeta inci
`drore, Cohexts were mak ordered from tlie highest 0 lowest
`Tato of pleural mesochetionias per J [HAP death.
`Table T summarizes the data for the 25 topronling
`esbealos cohorts. CHber atudies which were congidered but
`which ranked below te top 2.5 colocty axe listed in Table J,
`Cleyentile was the priniary exposure far al Inast oro of the
`10 top-vanking enbots GMancuse, 1988; Peto et 21, 135]
`and was the monudary expogore of identified as part of 4
`. Taited expogie in six of the 10 toprankiag eohovs, Cre
`cldotile was the primary expose for tee of the top 10
`cohorts [Fonea et ob.,.1980; Taloott et al, PORMcDenald
`amd McDonaid, 1972] ond war the paoondary expogire or
`identified 96 part of a mized cxpomee ia anothes five co
`hors, Amosite was identified agpartedarmixed exposurejn
`there olf the top 10 cohorts, bot was nel tha pelmary oxpa-
`Sire i any of them, These Hacings sugees that chrysorde,
`is a mogjor cases of pleural mesothelioma. They are jacon
`sistent with the claim thet amphibole fibers are much snom
`Poirot than chrysotile. IF thet were the case, one wonkd
`
`
`
`expect all the top 10 risk cohort io ba predominantly an
`PhiGole exposare ettharts.
`The baghent ratio of §8.1 plenmal inenutheliotas per
`1000 geaths waa for cailosd machlniste exposed tp
`chryscis (fencusc, L088), This stody hes been criticiend
`forattibuting he maothelioma incidence op chrysotile ex-
`posure rther than possible amphibole exposnre [Ohlson,
`983; McDoneld and MadDonald, 1989; Chuvg and Green,
`1290]. Maseuo's respenses to doch crificism demousirate-
`that the principal exposure ofthe rallroad mechinists was to
`Jogging <rremoval ofJansing, which wes ehrycotile, Whilo
`other jobs may have ozed amphiboles, fearing tw the pos
`sibiliy of secondary sspasum to the clroad workers, he
`Matin a sitong cane that chrypotile was the overviiebning
`fxpocupe bo the machinists [Maccase, 199Pa,b, LAH,
`A munber of ather epidemiclogical rhndies have been
`sublished but lack date tha: wuldathe calculaion ofple.
`ral mesethelioma ticidenee, Fidein et a). £1992) described a
`senes of mesothelioma cases Jn Cantdian ashesios wodkers,
`Al Of thnee cases wera ssen and accepted by the Cueber
`Workman's Cosnpeusation Boardforwork-relabed compen.
`sation of industrial disease. There were 49 enock in rainers
`and millersofthe Quebec Bastem Township regton. Twenty
`imesotbelionar occured in winers and rilless from Asher
`tos, Whore bemaliie conemingion was similar tp bark
`seman ura levels, “Cwenty-oine wmesothelinnias occured
`io worker from Thetford ines, wher bipher favels af
`Temolite too. The authors staked that, on dae basis of che
`aumaber of worker ‘exposed at each mine site, the inci
`dencesity Asbestos aad Therford Mines were simitae fléspite
`the differing levels of wemolite contamiuation. McDonald
`el aL [19D 1999) ooucucecd 4 cobort study of the miners
`and mifkas from Thetftord Mines andAabesto. Ondy 33 (25
`in the period 1975.-1933) mosothaliomes have been iden
`fied in the entire cohoct of abort 11,000 men, 80% ofwhom
`had died ag of 1992. According we the mthors, prohininage
`analysis ofmesotheliomas suggests eratdhe clkofmescithe-
`Toma was higher fn the ming and sails at Therford Pines
`(higher Gernotte exposure) than in those at Asbestos (lower
`Kemolile ayposuie). Their data, however, do not clearly
`suppose thie conclusion, expecially in che hivty SRpOSOre
`groups where thesates ofmesothelioma wee (07per 1000
`peteotl-years for Aghtitos and 0.92 por 1000 person-years
`fow Thetford Blines,
`.
`” 4 somber of other studies have democatzated teks oF
`mesothelioma die bo chrysotile exposure, Bar et al,
`LISTS] reported 72 cases of malignant mesockelionain Der-
`sons expoged prinerity io chrysotile in a asbestos mill.
`Fafiyiluee acerptable cases of chrysotile-indused meacihe-
`lidomat were identified by Caurg et ai. [JOSS]. Tae Bieg-
`nam messthclicnas wet ropated In a small sroap a?
`former chrysotile minces and snllers in Zimbshws [Culisn
`and Aaloyi, L991). A. case series af 60 mesotheliomas it
`
`railroad yolling-stock machinists agd others in the alan
`
`

`

`Fi
`Saceodeg|Wecior|Mire ey Ee AL reef freer
`
`
`caiott on
`=~
`ogee
`key
`Pet
`rect | lay
`lash pO eats eg emer ih, t,t Damani.
`
`
`
`
`
`
`
`
`
`
`
`
`cys aTuacoo MeadePaatby if 1” W Ge f a au BA ri
`“RarPrey
`Daehinitts
`* a
`aifram
`iki prep,Mtty |
`baa.
`eipois
`Win ite
`'
`Chek eal
`patty ge
`
`waco a minhoA
`Toe ae Deasucapc ke
`oyt
`Corraart
`BA
`a
`BS i
`a
`QU Seger bre crProne and
`u
`ao
`Paiet