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`EXHIBIT A
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`Case 1:18-cv-01363-CFC Document 84-1 Filed 03/22/19 Page 2 of 64 PageID #:
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`February, 2019
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`CURRICULUM VITAE
`
`Michael F. Press, M.D., Ph.D.
`
`
`A. Personal Information
`
`
`Michael Fredrick Press
`Name in Full:
`
`Business Address: Department of Pathology
`
`Norris Comprehensive Cancer Center
`
`Keck School of Medicine
`
`The University of Southern California
`
`1441 Eastlake Avenue; Room 5409
`
`Los Angeles, California 90033
`
`Business Telephone: (323) 865-0563
`FAX Number:
`(323) 865-0122
`
`Home Address:
`1338 Gates Place
`
`South Pasadena, California 91030
`Home Telephone:
`(323) 999-7417
`Place of Birth:
`St. Louis, Missouri
`
`Citizenship:
`U.S.A.
`E-mail Address:
`press@usc.edu or michael.press@med.usc.edu
`
`B. Education
`
`Roosevelt High School, St. Louis, Missouri, 1966
`High School:
`
`College/University: Washington University (St. Louis, MO), B.A. cum laude, 1970
`
`Graduate School:
`The University of Chicago, 1972 - 1975, Ph.D., 1975
`
`Medical School:
`The University of Chicago, 1970 - 1977, M.D., 1977
`
`Residency:
`Department of Pathology, The University of Chicago, Chicago, IL,
`1977-1981; Chief Resident, 1979-1981
`
`Fellowship Awards: 1. Recipient of N.I.H. Training Grant for combined M.D.-Ph.D.
`program (USPHS Graduate Training Grant No. 1-T32 HD-
`07009), 1972-1977.
`2. American Cancer Society Junior Faculty Clinical Fellow
`(JFCF#678), 1982-1985.
`3. The University of Chicago Faculty Traveling Fellowship
`(Fellow of Dr. Robert Scully, Harvard Medical School,
`M.G.H., Boston), 1984.
`4. Amoco Foundation Scholar, 1984-1985.
`5. Jessica M. Berman Senior Investigator Award, 2016-2021,
`Tower Cancer Research Foundation.
`
`The Harold E. Lee Chair in Cancer Research (July, 1998-present).
`Endowed Chair:
`
`Professional Recognition: Distinguished Scientists Seminar Series, Department of
`Biology, Howard University, Washington DC, October 3, 1996.
`
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`Press, Michael F.
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`William O. Russell Lectureship and Joanne Vandenberge Hill
`Award, M. D. Anderson Cancer Center, Houston, TX, January 29,
`2011 (has been given annually since 1977 to a pathologist who has
`“demonstrated outstanding professional achievement and who
`reflects the spirit and leadership of Dr. William Russell, former
`chairman of the Department of Pathology at M.D. Anderson
`Cancer Center.”)
`
`Donald L. Morton Award, 2016, given to the authors of the most
`downloaded article from the Journal of Surgical Oncology in the
`previous year.
`
`Jessica M. Berman Senior Investigator Award, 2016-2021, Tower
`Cancer Research Foundation.
`
`“Top Doctors”, Pasadena magazine, 2016 and 2017 (peer
`nominated and peer-reviewed regional recognition).
`
`Robert M. Nakamura Memorial Lecture,
`“HER2 Gene
`Amplification and Overexpression: Issues related to HER2 Testing
`and as a Target for Therapy”, Scripps Clinic, La Jolla, CA, June
`21, 2017.
`
`036-057906-1
`Medical Licensure: State of Illinois, 1978
`G 63073
`
`State of California, 1988
`M-11542
`State of Idaho, 2012
`14508
`State of Nevada, 2012
`2015-01962
`State of North Carolina, 2015
`ME 125489
`State of Florida, 2015
`
`Board Certification: American Board of Pathology (Anatomical Pathology), 1982.
`
`Sabbatical Leave:
`U.C.L.A. School of Medicine (with Dr. Dennis J. Slamon), 1987.
`
`C. Professional Background
`
`Academic Appointments
`Instructor, Department of Pathology, The University of Chicago, 1980-1981.
`Assistant Professor, Department of Pathology, The University of Chicago, 1981-1987.
`Assistant Professor, Department of Obstetrics and Gynecology, The University of Chicago,
`1985-1987.
`
`Associate Professor, Departments of Pathology and Obstetrics and Gynecology, The
`University of Chicago, 1987-1988.
`Associate Professor, Department of Pathology, University of Southern California, 1988 -
`1993.
`Professor, Department of Pathology, University of Southern California, 1993 - present.
`Harold E. Lee Chair in Cancer Research, 1998 – present.
`Lawrence J. Ellison Institute for Transformative Medicine of USC: Ellison Institute
`University Membership, 2018 – 2021.
`Clinical Service Appointments
`Associate Director, Autopsy Service, Department of Pathology, The University of Chicago,
`1981-1987.
`Surgical Pathologist, Chicago Lying-In Hospital, The University of Chicago, 1984-1987.
`
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`Clinical Laboratory Director and Consultant, Breast Cancer Analysis Laboratory,
`University of Chicago (1985-1988) and U.S.C. (1988-present)
`Surgical Pathologist, Women’s and Children’s Hospital, Los Angeles County + University
`of Southern California Medical Center, 1988-present.
`Director, USC Breast Cancer Analysis Laboratory, Norris Comprehensive Cancer Center,
`1988-present.
`Director, USC Clinical Laboratories Group, 2012 - present.
`
`Teaching Responsibilities
`Teaching Assistant in Gross Anatomy, Department of Anatomy, The University of Chicago, 1972.
`Teaching Assistant in Cell Biology-Histology, Department of Anatomy, The University of
`Chicago, 1973 and 1974.
`Teaching Assistant in Cell Pathology, Department of Pathology, The University of Chicago,
`1978.
`Teaching Assistant in Clinical Pathophysiology, The University of Chicago, 1979.
`Instructor in The Biology of Disease, The University of Chicago, 1980. (Reorganized
`and/or wrote two thirds of the laboratory sessions and taught all of the laboratory
`sessions.)
`Faculty for Clinical Pathophysiology, The University of Chicago, 1982-1987. (Lecturer
`and discussion leader for predominantly sophomore medical students.)
`Faculty for "Molecular Biology of Cancer" for USC Graduate students, 1993 – 1996, 2000-
`2002, 2017.
`Member, Academic Medicine Steering Committee for Medical Student “academic
`pathway” 2005-2006.
`Faculty for “Special Topics (Biomarkers)” for graduate students, course coordinator: Peter
`Danenberg, 2009-2011.
`Faculty for "Pathology of Organ Systems" for Year II USC medical students, 1989-present.
`Faculty for “Introduction to Pathology (INTD 550)” for graduate students, course
`coordinator: Louis Dubeau, 2005-present.
`Faculty for “Methods in Experimental Pathology Course (PATH 552b)” for graduate
`students, course coordinator: Robert Ladner / Joe Landolph, 2007-present.
`Teaching Award
`1993 recipient of the “Robert S. Cleland Excellence in Teaching Award” from the
`Graduate Students in the Department of Pathology, USC School of Medicine.
`Graduate Students Trained:
`Jason Lukas, 1991 – 1998, supported by a grant from the Norris Cancer Center BCRP
`Training Grant, 1995-1998; selected for the “Outstanding Graduate Student in
`Pathobiology Award” in the Dept. of Pathology, 1997; Ph.D. Thesis: “Molecular
`Genetic Alterations in Breast Cancer”, 1998. (M.D. degree, 2002, Allegheny Medical
`College for the Health Sciences, Pennsylvania; Resident in Internal Medicine, 2002-
`2005, University of Washington, Seattle, WA; 2005-2009, Fellow in Hematology-
`Oncology {Elizabeth Blackburn}, University of California at San Francisco, CA;
`Captain, U.S. Navy, 2009-2013; currently Assistant Professor, University of
`Washington, Cancer Care Alliance.)
`
`Bahman Saffari, 1993 - 1998, M.D.- Ph.D. student, selected for the “Outstanding Graduate
`Student Pathobiology Award” in the Dept. of Pathology, 1998; and as the sole
`recipient of the “Irving I. Lasky, M.D., Memorial Award” for research distinction in
`the 1998 medical school class by the Dean’s Office of Medical Education; Ph.D.
`Thesis, “Molecular Genetic Alterations in Endometrial Cancer”, 1998. (Resident
`Physician in Obstetrics and Gynecology, 1998-2002, USC; Gynecologic Oncology
`Fellowship, 2002-2006, University of California-Irvine, CA; gynecologic oncologist,
`Tacoma, WA, 2006 - present)
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`Wen-Hsiang Wen, M.D., 1993 – 1999, Ph.D. Thesis: “TP53 Alterations in Ovarian
`Carcinoma: Its Detection and Clinical Implications”, 1999. (Research Associate,
`1999-2002, USC; Resident Physician, 2005-2008, Department of Pathology, Hartford
`Hospital, CT; Molecular Pathology Fellowship, University of Pittsburgh, 2008-2009;
`molecular pathologist, Caris NPR, Phoenix, AZ, 2009 - present.)
`
`Jinha M. Park, 1995 - 2001, M.D.- Ph.D. student, supported by grants from the California
`BCRP Training Grant, 1996-1997; and US Army Medical Research and Materiel
`Command, DAMD17-97-1-7161, 1997 – 2000; “Irving I. Lasky, M.D., Memorial
`Award” for medical student research, 2001 (Dean’s Office of Medical Education);
`Ph.D. Thesis: “The HER-2/neu Oncogene in Human Breast Cancer: From Molecular
`Mechanisms to Targeted Therapies”, 2001. (2001-2002, Internship, Internal
`Medicine, Kaiser Permanente Medical Center, Los Angeles; 2002-2008, Resident
`Physician in Radiology, UCLA School of Medicine, LA, CA; Assistant Professor of
`Radiology, USC/Keck School of Medicine, 2008-2011; Assistant Professor of
`Radiology, City of Hope, 2011-2015; Clinical Associate Professor, University of
`Iowa Hospitals and Clinics, 2018 - present)
`
`John J. Park, 1996 - 2002, M.D.- Ph.D. student, supported by a grant from the US Army
`Medical Research and Materiel Command, DAMD17-97-1-7232, 1997 – 2000; Ph.D.
`Thesis: “Breast Cancer Susceptibility Gene 1: A Role in Transcriptional
`Regulation”, 2002. (Resident Physician in Urology, 2002-2003, USC; Resident
`Physician in Radiology, 2003-2008, Resident Physician in Radiology, UCLA School
`of Medicine, LA, CA; Assistant Professor of Radiology, USC/Keck School of
`Medicine, 2008-2011; Assistant Professor of Radiology, City of Hope, 2011-present)
`
`Marianna Keshmeshian, 1997 - 2004, (supported by a grant from the California BCRP
`Training Grant, 1997-2001); Ph.D. Thesis: “Association of HER2 Overexpression
`with an Increased Rate of Cell Migration, Cell Invasion and Matrix Metalloproteinase
`Production”. (Mariana {Keshmeshian} Rostamian, 2005-present, Medical Science
`Liaison, Medical Affairs, Ligand Pharmaceuticals Inc., Northridge, CA; Medical
`Science Liaison, Medical Affairs, Amgen, Inc.; Senior Medical Liaison, US Medical
`Affairs, AstraZeneca).
`
`Jean Wei, 1998 – 1999, (Dept of Pathology graduate student) (supported by a grant from
`the California BCRP Training Grant, 1998-1999).
`
`Dorothy Hong, 1999 – 2001, Master’s Degree Program, Dept. of Pathology, USC; M.S.
`degree in Molecular and Experimental Pathology, May, 2001. (USC Keck School of
`Medicine, 2001-2005, M.D.; Resident Physician, 2005-2009, Department of
`Obstetrics and Gynecology, USC; Obstetrician-Gynecologist, private practice, Los
`Angeles, CA).
`
`Seukyoung Kong, 2000 – 2003, (Dept of Pathology graduate student).
`
`Veronica Lagos-Jaramillo, 2004 – 2005, Master’s Degree Program, Dept. of Pathology,
`USC; M.S. degree
`in Molecular and Experimental Pathology, May, 2005;
`(subsequently medical genetics technician, City of Hope, 2005-2009; M.D., Oregon
`Health & Science University School of Medicine, 2009-2013; Internal Medicine
`Residency, Santa Clara Valley Medical Center, San Jose, CA {Stanford University
`Affiliation}, 2013-present).
`
`Sherin Shirazi, M.D., 2006 – 2009. (Ph.D. candidate, Department of Pathology, USC).
`
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`Press, Michael F.
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`
`
`Ma’mon Hatmal, 2006 – 2007. (Master’s Degree Program, Department of Microbiology,
`USC).
`
`Anamaria Ioannou, M.D., 2004 – 2010. (Ph.D. graduate student, Department of Pathology,
`USC), Ph.D. Thesis: "Genetic Alterations in Nuclear Receptor Coactivators in Breast
`Cancer", Department of Pathology, USC (Postdoctoral Fellow, 2010-2012, USC);
`current position: Resident Physician, Department of Pathology, Harbor-UCLA
`Hospital, Torrance, CA, 2018 - 2022.
`
`Michael Gordon, 2008 – 2013; Ph.D. graduate student, Department of Pathology, USC;
`Ph.D. Thesis: “HER2 gene amplification and co-amplified genes in gastric and breast
`carcinomas”; postdoctoral fellowship, University of Colorado (Jennifer Richer), 2013
`– 2017; solid tumor medical science liaison, AbbVie Inc, 2017 - present.
`
`Anaamika Campeau, 2014-2016; M.S. graduate student, MS Thesis: “Aneusomy and
`Proliferative Rates: Distortion of HER2 Gene Amplification Status by Fluorescence
`in situ Hybridization (FISH) in Breast Cancer”, Department of Pathology, USC;
`current position: Ph.D. graduate student, University of California, San Diego.
`
`Ryan LaRue, 2016 – 2018; M.S. Graduate student, MS Thesis: “Estrogen Receptor-beta
`Characterization in Breast Cancer: Development of a Reliable Assay for Measuring
`Expression”, Department of Pathology, USC.
`Membership on Ph.D. Thesis Committees of other faculty members' students:
`Jon Milhon (Michael Stallcup, PhD), Dept. of Pathology, Thesis Defense, 1992.
`Christopher Biggs (Timothy Triche, MD, PhD), Dept. of Pathology, Thesis Defense, 1993.
`Arthur Lazik, MD (Arnis Richters, PhD; Johannes Groffen, PhD), Dept. of Pathology, 1993.
`Allen S. Yang (Peter Jones, PhD), Dept. of Biochemistry, 1994.
`Michaela Velicescu, (Louis DuBeau, MD, PhD), Dept. of Pathology, Oral Examination,
`1994; Thesis Defense, scheduled for January 4, 1999.
`Abdi Mohit (Carol Miller, MD), Dept. of Pathology, Oral Examination, 1992; Thesis
`Defense, 1995.
`Jason Hornick (Alan Epstein, MD, PhD), Department of Pathology, Oral Examination,
`1995; Thesis Defense, 1997.
`Christopher Logg (Nori Kasahara, MD, PhD) Dept. of Pathology, Oral Examination, 1998.
`Arthur Lazik (Arnis Richters, PhD and Robert Maxson, PhD), Dept. of Pathology, Thesis
`Defense, 1998.
`Jinsong Xu (Peter Brooks, PhD) Dept. of Biochemistry and Molecular Biology, 2001.
`JiaLi Li (Alan Epstein, MD, PhD), Dept. of Pathology, 2001.
`Alpa Patel (Leslie Bernstein, PhD), Dept. of Preventive Medicine, 2002.
`Julie Ann Mayer (Cheng-Ming Chuong, MD, PhD), Dept. of Pathology, 2005.
`Michael Hadjidaniel (C. Patrick Reynolds, MD, PhD), Dept. of Pediatrics, 2005-2008.
`Ilana Pootrakul (Richard Cote, MD, PhD), Dept. of Pathology, 2005.
`Joshua Fields (Wei Li, PhD), Dept. of Dermatology, 2006.
`Jennifer Yeh (Louis Dubeau, PhD), Dept. of Pathology, 2006.
`Vanessa Yu (Louis Dubeau, PhD), Dept. of Pathology, 2006.
`Aruni De Silva (Joseph R. Landolph, PhD), Dept. of Molecular Microbiology &
`Immunology, 2006-2008.
`Melissa LaBonte (Robert Ladner, PhD), Dept. of Pathology, 2006-2010.
`Tanmai Saxena (Giske Ursin, MD, PhD), Dept. of Preventive Medicine, 2009-2011.
`Christine Marion (Louis Dubeau, MD, PhD; committee chair: Press, MF) Dept of
`Pathology, 2011-2014.
`Zhengfei Lu (Michael Lieber, MD, PhD), Dept of Pathology, 2012-2014.
`Anne Dee (Roberta McKean-Cowden, PhD), Dept of Preventive Medicine, 2012-2014.
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`Press, Michael F.
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`Shuangchao Ma (Michael Lieber, MD, PhD), role: committee chair, Dept of Pathology,
`2014-present.
`Zitadel Anne Esguerra (Michael Lieber, MD, PhD), Dept of Pathology, 2014-present.
`Marilena Melas (Stephen Gruber, MD, PhD, MPH), Cancer Biology and Genomics
`program at USC (PIBBS program), member oral qualifying committee and Chair thesis
`committee, 2016-present.
`Christina Gerodimos (Michael Lieber, MD, PhD), PhD candidate, role: committee chair,
`Dept of Pathology, 2016-present.
`Di Liu (Michael Lieber, MD, PhD), PhD candidate, role: committee chair, Dept of
`Pathology, 2017-present.
`Rishi Rawat (David Agus, MD), MD-PhD candidate, role: committee member, 2017-
`present.
`Ugonna Ihenacho (Ann Hamilton, PhD), PhD candidate, role: committee member, 2018 –
`present.
`
`Post-doctoral Fellows Trained in my laboratory:
`Martin Bur, MD 1984-1985. (Associate Professor, Dept of Pathology, Univ. of
`Massachusetts)
`Jie-dong Wang, MD 1986-1987.
`Gene Hung, MD 1989-1992.
`Wolfgang Friedmann, MD 1990-1991. (now Professor, Department of Obstetrics and
`Gynecology, Charite School of Medicine, Berlin, Germany)
`Yangling Ma, MD 1993-1994 (now Professor and Director of Surgical Pathology,
`Department of Pathology, USC Keck School of Medicine).
`Laila Dahmoush, MD 1991- 1995 (now Associate Professor, Department of Pathology,
`University of Iowa).
`Angela Reles, MD 1992, 1996 - 1998. (now Assistant Professor, Department of Obstetrics
`and Gynecology, Charite School of Medicine, Berlin, Germany)
`Joaquina Baranda, MD 1994-1995 (now Associate Professor, Department of Medicine,
`University of Kansas, Kansas City, MO)
`Xiaowei Yang, MD, PhD 1995 – 1998 (now Chief, National Clinical Target Validation
`Laboratory, Division of Cancer Treatment and Diagnosis, National Cancer Institute).
`M. Patrick Lowe, MD (Gynecologic Oncology) 2003-2004. (2007-2011: Assistant
`Professor at Northwestern University School of Medicine, Chicago, IL; co-founding
`partner of the Gynecologic Cancer Institute of Chicago. Dr. Lowe is the Director of
`Gynecologic Oncology and the Director of the Robotic Surgery Program at Advocate
`Christ Medical Center and an Assistant Clinical Professor at the University of Illinois
`at Chicago College of Medicine.)
`Wendy J. Levin, MD, MS, (Dept of Medicine) 2004 (currently medical oncologist, Pfizer,
`Inc.)
`Melinda Epstein, PhD 2004 – 2009 (currently Research Associate, VA Hospital, UCLA).
`Luis J. Santos Reyes, MD (Gynecologic Oncology) 2006-2007 (currently Assistant
`Professor, University of Puerto Rico)
`Merieme Klobocista, MD (Gynecologic Oncology) 2007-2008. (currently Assistant
`Professor and Attending Physician in the Department of Obstetrics & Gynecology
`and Women's Health, Division of Gynecologic Oncology at Albert Einstein College
`of Medicine and Montefiore Medical Center. She is also the director of Albert
`Einstein College of Medicine and Jacobi Medical Center Department of Obstetrics &
`Gynecology, Gynecologic Oncology Service).
`Wafaa Elatre, MD, 2010 – 2011; (currently Assistant Clinical Professor of Pathology,
`USC, Los Angeles).
`Anamaria Ioannou, M.D., Ph.D., 2010 – 2012, "Genetic Alterations in Nuclear Receptor
`Coactivators in Breast Cancer".
`
`Mentorship of junior faculty members:
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`Press, Michael F.
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`Jiang (John) Zhong, PhD (Assistant Professor, USC Department of Pathology and Herman
`Ostrow School of Dentistry), 2012-present.
`Julie Lang, MD (Assistant Professor, USC Department of Surgery), 2012-present.
`Keane Lai, MD (Assistant Professor, USC Department of Pathology), 2012 - 2018; 2018 –
`present, Associate Professor of Pathology, City of Hope National Medical Center,
`Duarte, California.
`Christina Curtis, PhD, MS (Assistant Professor, USC Department of Preventive Medicine)
`2013-2014; 2014-present (Associate Professor, Department of Medicine, Stanford
`University).
`Josh Neman-Ebrahim, PhD (Assistant Professor, USC Department of Neurosurgery), 2014-
`present.
`Huy Pham, MD, (Assistant Professor, USC Department of Pathology), 2018 - present.
`Pamela Ward, PhD, (Associate Professor, USC Department of Pathology), 2018 - present.
`
`Administrative Responsibilities / Committee Membership
`Associate Director, Autopsy Service, Department of Pathology, The University of Chicago,
`1981-1987.
`Member, Tissue Committee of the Medical Staff Organization, The University of Chicago,
`1981-1986.
`Member, Scientific Review Committee, U.S.C., American Cancer Society Institutional
`Grant, 1988-1996.
`Member, U.S.C. Institutional Research Board (reviews research protocols involving human
`subjects) 1990-1991
`Ad Hoc Member, Promotions Committee, U.S.C. 1989, 1990, 1992.
`Member, Graduate Student Committee, Department of Pathology, University of Southern
`California, 1989 - 1995; Chairman for Graduate Admissions to Pathology, 1991 -
`1994.
`Member, M.S.T.P. (MD/PhD) Admissions Committee, USC, 1989 - present.
`Member, Curriculum Committee, years I and II for medical students, USC, 1990-1991.
`Chairman, Postdoctoral Fellowship Support Committee, Norris Cancer Center, 1993 -
`1996.
`Coordinator, Tumor Biology Program, U.S.C. Cancer Center, 1994.
`Member, Norris Cancer Center Advisory Committee, 1994-present.
`Chairman, Research Design Team, USC School of Medicine, 1995.
`Member, Biological Safety Committee, 1996 - 2000.
`Vice-Chair for Academic Affairs, Department of Pathology, USC School of Medicine,
`1995 - 1997.
`Chair, Committee for Recruitment to the Breast Cancer Program, Norris Cancer Center,
`1996-1998. (one basic scientist {Peter Brooks, PhD} and one surgical oncologist
`{Mel Silverstein, MD})
`Member, Task Force for the Development of Junior Faculty, USC School of Medicine,
`1997-1998.
`Member, Breast Cancer Executive Committee, Norris Cancer Center, University of
`Southern California, 1999 – 2005.
`Member, REACH Program, Department of Pathology, University of Southern California,
`2000 - 2004.
`Member, University Pathology Associates, Inc., Advisory Committee, 2008-2009.
`Member, Faculty Oversight Users Committee for Glassware and Shared Equipment Core,
`USC Norris Comprehensive Cancer Center, 2004-2005.
`Co-Leader, Breast Cancer Research Program, USC Norris Comprehensive Cancer Center,
`1993 - 2003.
`Co-Leader, Women’s Cancers Research Program, USC Norris Comprehensive Cancer
`Center, 2003 - 2013.
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`Member, National Breast Cancer Bioresource Scientific Advisory Board, Dublin, Ireland,
`2011-2012.
`PacRim Breast and Prostate Cancer Group: 2015 International Advisory Committee (IAG).
`Member, Faculty Advisory Committee, Department of Pathology, USC, 2013 - present.
`UCLA External Advisory Board, T32 training grant, “Academic Training in Medical
`Oncology”, 2015-present.
` Other Employment or Administrative Activity
`Director, USC Clinical Laboratories Group, 2012 – present.
`Director, Breast Cancer Analysis Laboratory, USC, 1984 – present.
`Director, Central Laboratory and European Laboratory, Breast Cancer International
`Research Group (CIRG), currently known as Translational Research In Oncology
`(TRIO), 2000-2004 and 2007-present.
`Cancer International Research Group (CIRG) / Translational Research in Oncology (TRIO)
`Member, Steering committee for BETH clinical trial (2007-2014)
`
`
`Chair, Translational Research Committee, BETH clinical trial (2007-2014)
`
`Co-Chair, Translational Research Committee, LOGiC clinical trial (2008-present)
`Member, Steering Committee, Translational Research in Oncology (TRIO)-020
`clinical trial, trial closed to further accrual in 2016 (2014-2016).
`Member, Translational Research Committee, KRISTINE (BO28408/TRIO-021): “A
`Randomized, Multicenter, Open-Label, Two-Arm, Phase III Neoadjuvant Study
`Evaluating Trastuzumab Emtansine Plus Pertuzumab
`compared with
`Chemotherapy plus Trastuzumab and Pertuzumab for Patients with HER2-
`Positive Breast Cancer” which is an international clinical trial of HER2-positive
`early breast cancer patients treated with neoadjuvant docetaxel plus carboplatin
`and trastuzumab followed by pertuzumab (TCH+P) conducted from 2015-2017.
`
`Professional Service
`Editorial Board Membership:
`International Journal of Gynecological Pathology, 1995 - 2005.
`Applied Immunohistochemistry and Molecular Morphology, 1994 - 1999.
`Advances in Anatomic Pathology, 1994 - 2016.
`Frontiers in Molecular Medicine, 2014- 2017
`Breast Cancer Research and Treatment, 2011 – present.
`
`Study Sections:
`National Cancer Institute of Canada; Ad hoc reviewer for the Molecular Epidemiologic -
`Clinical Correlative Studies Program, 1992.
`National Institutes of Health (US); Reproductive Endocrinology Study Section, Ad hoc
`reviewer, 1992, 1993. Pathology B Study Section, Ad hoc reviewer, 1994, 1998.
`U.S. Army Medical Research & Materiel Command, Pathobiology #5 Study Section, 1996.
`U.S. Army Medical Research & Materiel Command, Integration Panel, 1997.
`National Cancer Institute; “reviewer for the Breast Cancer Surveillance Consortium
`Expansion Panel”, 1999.
`U.S. Army Medical Research & Materiel Command, TPC Study Section, 2000.
`Integration Panel, ad hoc member, Breast Cancer Research Program, U.S. Army Medical
`Research & Materiel Command, 2005.
`University of Chicago Specialized Program of Research Excellence (SPORE) in Breast
`Cancer: External Advisory Committee, 2008 – 2013.
`Integration Panel, ad hoc member, Breast Cancer Research Program, U.S. Army Medical
`Research & Materiel Command, 2011, 2012, 2013.
`National Institutes of Health (US); Ad hoc reviewer for NCI Special Emphasis Panel to
`review R21/R03 applications: Cancer Biology 3 study section, June 2013.
`U.S. Army Medical Research & Materiel Command; Ad hoc member, Subgroup 3,
`Integration Panel, May 20-21, 2014.
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`U.S. Army Medical Research & Materiel Command; Ad hoc member, Integration Panel,
`programmatic review of FY15 Breakthrough Award - Funding Levels 1 and 2
`applications, August 11, 2015.
`U.S. Army Medical Research & Materiel Command; Ad hoc member, Integration Panel,
`programmatic review of FY16 Breakthrough Award - Funding Levels 1 and 2
`applications, April 12, 2016.
`U.S. Army Medical Research and Materiel Command Breast Cancer Research Program
`(BCRP) Programmatic Panel for the programmatic review of fiscal year 2016 (FY16)
`BCRP Breakthrough Award Funding Levels 1 and 2 and Breakthrough Fellowship
`Award applications; ad hoc member, September 13, 2016.
`U.S. Army Medical Research and Materiel Command Breast Cancer Research Program
`(BCRP) Programmatic Panel for the programmatic review of fiscal year 2017 (FY17)
`BCRP Breakthrough Award Funding Levels 1 and 2; ad hoc member, October 10,
`2017.
`U.S. Army Medical Research and Materiel Command Breast Cancer Research Program
`(BCRP) Programmatic Panel for the programmatic review of fiscal year 2018 (FY18)
`BCRP Breakthrough Award Funding Levels 1 and 2; ad hoc member, September 24-
`25, 2018.
`
`National Organizations:
`Cancer Education Committee, American Society of Clinical Oncology, May 18, 2005 –
`2008.
`
`External Advisory Boards / Organizations:
`Member, External Advisory Board, University of Chicago, Specialized Program in
`Research Excellence (SPORE) in Breast Cancer, External Advisory Committee,
`2008-2013.
`Member, External Advisory Board, Women's Cancers Program, City of Hope National
`Medical Center, Duarte, CA; (2010 - 2013).
`Outside Reviewer, Academic Program Review, Department of Pathology, University of,
`Tucson, AZ, April 14-15, 2015.
`
`D. Society Memberships
`American Association of Pathologists, 1984 - present.
`International Academy of Pathology, 1983 - present.
`International Society of Gynecological Pathologists, 1984 - present.
`American Association for the Advancement of Science, 1986 - present.
`American Association for the Advancement of Cancer Research, 1992 - present.
`American Society for Clinical Oncology, 2005 - present.
`
`E. Consultantships / Industry Collaborations.
`Cell Analysis Systems, Inc. (Elmhurst, IL), Consultant for computerized image analysis,
`1985-1989.
`Oncor, Inc. (Gaithersburg, MD), Consultant, 1992 - 1996.
`ChromaVision Medical Systems, Inc., Scientific Advisory Board, (San Juan Capistrano,
`CA), 1998 - 2001.
`Chiron, Inc. (Emeryville, CA), 1998 - 1999.
`Genentech, Inc. (San Francisco, CA), Scientific Advisory Boards, 2000 – 2001, 2004,
`2010, 2011.
`Vysis, Inc. (Chicago, IL), Scientific Advisory Board, 2001- 2002.
`CeMines, Inc., Scientific Advisory Board, 2003 – 2004.
`ACLARA, Inc., Consultant, 2003 – 2005.
`Cepheid, Inc., Consultant, 2004 – 2006, 2011-2018.
`Exagen, Inc., Scientific Advisory Board, 2006 – 2007.
`Ventana Medical Systems, Inc., Scientific Advisory Board, 2010, 2011, 2015.
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`Sanofi-aventis/BiPar pharmaceuticals, Triple Negative Breast Cancer, Scientific Advisory
`Board, 2010, 2011.
`GlaxoSmithKline, P95 Scientific Advisory Board, 2010, 2011.
`Halozyme, Inc., Scientific Advisory Board and Consultant, 2011 - 2016.
`GlaxoSmithKline, Expert Oncology Panel, 2012 - 2014.
`Amgen, Inc., Amgen Oncology Global Advisory Board, June, 2013.
`Biocartis, Inc., Scientific Advisory Board, 2013 – present.
`Puma Biotechnology, Inc., Conusltant, 2014 - 2015 and 2016 - 2017.
`Trevigen, Inc., Consultant, 2015.
`ADC Therapeutics, Inc., 2016 - 2017.
`Eli Lilly, Consultant, 2016.
`Karyopharm Therapeutics, Consultant, 2016 – 2017.
`Brogent International LLC, Consultant, 2017 – present.
`
`F. Community Activities
`Expedition Inspiration (Breast Cancer Advocacy organization).
`Medial Advisory Committee, member (2007-present).
`Breast Cancer Network of Strength (formerly Y-Me National Breast Cancer Organization),
`Southern California Affiliate, Board member (2007-2010).
`
`G. Patents
`Title: “Quantitative Measurement of Tissue Protein Identified by Immunohistochemistry
`and Standardized Protein Determination.”
`Inventors: Michael Press and Dennis Slamon.
`U.S. Patent number: 5,846,749.
`Title: “Honeycomb Tissue Block.”
`Inventors: Michael Press and Karen Petrosyan.
`U.S. Patent application number: 09/443,927.
`
`Title: “Targeted Delivery of Therapeutic and Diagnostic Moieties.”
`Inventors: Michael Press and Jinha Park.
`U.S. Patent application number: 09/712,869.
`
`Title: “Isolation and characterization of ECA1, a gene overexpressed in endometrioid
`carcinomas of ovary and endometrium”.
`Inventors: Michael F. Press and Bahman Saffari.
`U.S. Patent application number: 7,371,840 (issued on May 13, 2008).
`
`Title: “MYST2 gene amplification as a diagnostic predictive marker in patients with
`HER2-positive breast cancer”
`Inventors: Michael F. Press and Michael A. Gordon.
`U.S. Patent application number: 61 / 776690 (March 10, 2014).
`
`Patent disclosure:
`Title: “Mediation of Cytokinesis by Polo-like Kinase 4”
`Inventors: Michael F. Press and Dennis J. Slamon (UCLA)
`U.S. Patent application number: 62/323,492 (March, 2016), USC abandoned the
`provisional application in April, 2017 for lack of licensing interest.
`
`
`
`H. Clinical Trials Research Activity with our laboratory as the Central Laboratory (USC
`Breast Cancer Analysis Laboratory / Press Consultation Laboratory: CLIA certified
`{05D1072620}, State of California Department of Public Health licensed {CLA
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`00335392} and College of American Pathologists accredited {Accreditation no.
`7177225}).
`
`1. “HER-2/neu gene amplification characterized by fluorescence in situ hybridization: Poor
`prognosis in node-negative breast carcinomas”, Pre-market approval (PMA) submission to
`the U.S. Food and Drug Administration (FDA) for the Oncor INFORM HER-2/neu Gene
`Detection System, (retrospective study of archived tissues), 1993, n = 140 and 324 patients.
`
`2. GNE H0648, H0649 and H0650 trials: “Evaluation of clinical outcomes according to HER2
`detection by fluorescence in situ hybridization in women with metastatic breast cancer
`treated with trastuzumab”, PMA submission to FDA for the Vysis, PathVysion HER2
`FISH assay, (retrospective study of archived tissues from three different prospective
`clinical trials of trastuzumab in metastatic breast cancer patients, 1999-2000, n = 469, 222
`and 114 patients.
`
`3. Sanofi and Breast Cancer International Research Group (BCIRG) 006 Trial (NCT00021255):
`“Multicenter phase III randomized trial comparing doxorubicin and cyclophosphamide
`followed by docetaxel (AC—>T) with doxorubicin and cyclophosphamide followed by
`docetaxel and trastuzumab (Herceptin) (AC—>TH) and with docetaxel, carboplatin and
`trastuzumab (TCH) in the adjuvant treatment of node positive and high