Case 1:20-cv-00125-GBW Document 504 Filed 10/25/22 Page 1 of 4 PageID #: 53664
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`IN THE UNITED STATES DISTRICT COURT
`FOR THE DISTRICT OF DELAWARE
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`C.A. No. 20-125 (GBW)
`(CONSOLIDATED)
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`)))))))))
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`NATERA, INC.,
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`Plaintiff,
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`v.
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`ARCHERDX, INC., ARCHERDX, LLC and
`INVITAE CORP.,
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`Defendants.
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`NATERA INC.’S CONCISE OF FACTS IN OPPOSITION TO DEFENDANTS’ MOTION
`FOR SUMMARY JUDGMENT THAT DEFENDANTS PCM, STRATAFIDE, AND
`LIQUIDPLEX PRODUCTS DO NOT INFRINGE ANY OF THE ASSERTED PATENTS
`(D.I. 430 at 11-13; D.I. 449 at 4-5)
`
`MORRIS, NICHOLS, ARSHT & TUNNELL LLP
`Jack B. Blumenfeld (#1014)
`Derek J. Fahnestock (#4705)
`Anthony D. Raucci (#5948)
`1201 North Market Street
`P.O. Box 1347
`Wilmington, DE 19899-1347
`(302) 658-9200
`jblumenfeld@morrisnichols.com
`dfahnestock@morrisnichols.com
`araucci@morrisnichols.com
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`Attorneys for Plaintiff Natera, Inc.
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`OF COUNSEL:
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`Bhanu K. Sadasivan
`MCDERMOTT WILL & EMERY LLP
`650 Live Oak Ave., Suite 300
`Menlo Park, CA 94025
`(650) 815-7400
`
`William G. Gaede, III
`Jodi L. Benassi
`MCDERMOTT WILL & EMERY LLP
`415 Mission Street, Suite 5600
`San Francisco, CA 94105
`(628) 218-3800
`
`Mandy H. Kim
`MCDERMOTT WILL & EMERY LLP
`18565 Jamboree Road, Suite 250
`Irvine, CA 92612
`(949) 757-6061
`
`October 25, 2022
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`

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`Case 1:20-cv-00125-GBW Document 504 Filed 10/25/22 Page 2 of 4 PageID #: 53665
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`In accordance with the Court’s October 3, 2022 Order (D.I. 461), Plaintiff Natera Inc.
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`(“Natera”) respectfully submits this separate concise statement of material facts as to which there
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`exists a genuine issue warranting denial of Defendants’ Motion for Summary Judgment that
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`Defendants’ PCM, Stratafide, and LiquidPlex Products Do Not Infringe Any of the Asserted
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`Patents.
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`1.
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`The Court construed the term “target loci” to mean “selected segments of nucleic
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`acid of interest of an individual. D.I. 243 (Markman Opinion), 5.
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`2.
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`The Court’s construction expressly included scenarios where multiple DNA
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`sources are present and the circulating tumor DNA is selected as the target:
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`It may be that a single biological sample may contain material from multiple
`individuals. It may be possible, nonetheless, to practice the claims on such a
`sample, provided that each time it is practiced all of the target loci are selected from
`a single individual (i.e., the portion of the sample that is derived from that same
`single individual). For example, an individual looking to test for Y chromosome
`linked disorders could obtain a sample of mixed DNA from a mother and a fetus,
`target DNA of the fetus, and practice the claim with respect to the target loci of
`that fetus despite the presence of multiple DNA sources in the sample (Tr. at 27-
`28) The Court’s construction is not intended to exclude such possibilities.
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`D.I. 243 (Markman Opinion), 6, fn. 3 (emphasis added).
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`3.
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`Defendants admitted: “just because you have a mixed sample that includes DNA
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`from multiple individuals doesn’t mean you can’t target DNA from just one individual. You surely
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`can. I just gave you an example of what you could do.” D.I. 442 (Natera’s Opposition to
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`Defendants’ Motion for Summary Judgment), 10 (citing D.I. 185 (Claim Construction Hearing
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`Tr.), 27:20-24).
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`4.
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`The specification expressly contemplate that the source of DNA target loci can be
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`from more than one individual. D.I. 17-1, Ex. 1 (’814 Patent), 105:28-30 (“whether the sample is
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`[sic] pure genomic sample from a single individual or mixture of individuals”).
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`

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`Case 1:20-cv-00125-GBW Document 504 Filed 10/25/22 Page 3 of 4 PageID #: 53666
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`5.
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`U.S. Patent No. 8,515,679 titled “System and Method for Cleaning Noisy Genetic
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`Data and Determining Chromosome Copy Number,” is not an asserted patent in this action. D.I.
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`452-12 (’679 Patent), Ex. 3.
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`6.
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`U.S. Patent No. 10,526,658 titled “Methods for Simultaneous Amplification of
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`Target Loci,” is not at issue in this action, and is not a family member of the Asserted Patents. D.I.
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`434-2, Ex. B (Spellman Tr.), 46:13-14.
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`7.
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`The term “individual” is not recited in the asserted claims of the ’220, ’814, and
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`’172 Patents. D.I. 17-1, Ex. 1 (’814 Patent), Claim 1; D.I. 17-1, Ex. 2 (’172 Patent), Claim 1; D.I.
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`391-2, Ex. 5 (’220 Patent), Claim 1.
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`OF COUNSEL:
`
`Bhanu K. Sadasivan
`MCDERMOTT WILL & EMERY LLP
`650 Live Oak Ave., Suite 300
`Menlo Park, CA 94025
`(650) 815-7400
`
`William G. Gaede, III
`Jodi L. Benassi
`MCDERMOTT WILL & EMERY LLP
`415 Mission Street, Suite 5600
`San Francisco, CA 94105
`(628) 218-3800
`
`Mandy H. Kim
`MCDERMOTT WILL & EMERY LLP
`18565 Jamboree Road, Suite 250
`Irvine, CA 92612
`(949) 757-6061
`
`October 25, 2022
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`MORRIS, NICHOLS, ARSHT & TUNNELL LLP
`
`/s/ Derek J. Fahnestock
`
`Jack B. Blumenfeld (#1014)
`Derek J. Fahnestock (#4705)
`Anthony D. Raucci (#5948)
`1201 North Market Street
`P.O. Box 1347
`Wilmington, DE 19899-1347
`(302) 658-9200
`jblumenfeld@morrisnichols.com
`dfahnestock@morrisnichols.com
`araucci@morrisnichols.com
`
`Attorneys for Plaintiff Natera, Inc.
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`2
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`

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`Case 1:20-cv-00125-GBW Document 504 Filed 10/25/22 Page 4 of 4 PageID #: 53667
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`CERTIFICATE OF SERVICE
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`I hereby certify that on October 25, 2022, I caused the foregoing to be electronically filed
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`with the Clerk of the Court using CM/ECF, which will send notification of such filing to all
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`registered participants.
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`I further certify that I caused copies of the foregoing document to be served on October 25,
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`2022, upon the following in the manner indicated:
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`Brian E. Farnan, Esquire
`Michael J. Farnan, Esquire
`FARNAN LLP
`919 North Market Street, 12th Floor
`Wilmington, DE 19801
`Attorneys for Defendants
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`Edward R. Reines, Esquire
`Derek C. Walter, Esquire
`WEIL, GOTSHAL & MANGES LLP
`201 Redwood Shores Parkway
`Redwood Shores, CA 94065
`Attorneys for Defendants
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`Ian Moore, Esquire
`WEIL, GOTSHAL & MANGES LLP
`767 Fifth Avenue
`New York, NY 10153
`Attorneys for Defendants
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`Priyata Y. Patel, Esquire
`WEIL, GOTSHAL & MANGES LLP
`2001 M Street NW, Suite 600
`Washington, DC 20036
`Attorneys for Defendants
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`VIA ELECTRONIC MAIL
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`VIA ELECTRONIC MAIL
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`VIA ELECTRONIC MAIL
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`VIA ELECTRONIC MAIL
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`/s/ Derek J. Fahnestock
`__________________________
`Derek J. Fahnestock (#4705)
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