Case 1:25-cv-00140-JLH Document 1-4 Filed 02/03/25 Page 1 of 56 PageID #: 202
`Case 1:25-cv-00140-JLH Document1-4
`Filed 02/03/25
`Page 1 of 56 PagelD #: 202
`
`EXHIBIT 4
`
`EXHIBIT 4
`
`

`

`( 12 ) United States Patent
`Islam
`
`US 10,874,304 B2
`( 10 ) Patent No .:
`( 45 ) Date of Patent :
`* Dec . 29 , 2020
`
`US010874304B2
`
`( * ) Notice :
`
`( 54 ) SEMICONDUCTOR SOURCE BASED NEAR
`INFRARED MEASUREMENT DEVICE WITH
`IMPROVED SIGNAL - TO - NOISE RATIO
`( 71 ) Applicant : Omni Medsci , Inc. , Ann Arbor , MI
`( US )
`( 72 ) Inventor : Mohammed N. Islam , Ann Arbor , MI
`( US )
`( 73 ) Assignee : OMNI MEDSCI , INC . , Ann Arbor , MI
`( US )
`Subject to any disclaimer , the term of this
`patent is extended or adjusted under 35
`U.S.C. 154 ( b ) by 0 days .
`This patent is subject to a terminal dis
`claimer .
`( 21 ) Appl . No .: 16 / 669,794
`( 22 ) Filed :
`Oct. 31 , 2019
`( 65 )
`Prior Publication Data
`US 2020/0077898 A1
`Mar. 12 , 2020
`Related U.S. Application Data
`Continuation of application No. 16 / 284,514 , filed on
`Feb. 25 , 2019 , now abandoned , which is
`( Continued )
`
`( 60 )
`
`a
`
`( 56 )
`
`CA
`CN
`
`References Cited
`U.S. PATENT DOCUMENTS
`4,063,106 A
`4,158,750 A
`
`12/1977 Ashkin et al .
`6/1979 Sakoe et al .
`( Continued )
`FOREIGN PATENT DOCUMENTS
`
`9/2004
`2458123 A1
`101849821 A 10/2010
`( Continued )
`
`OTHER PUBLICATIONS
`Inter Partes Review No. IPR2020-00175 ; Petition for Inter Partes
`Review of U.S. Pat . No. 10,188,299 ; Apple Inc. V. Omni Medsci ,
`Inc .; pp . 1-91 ; dated Dec. 11 , 2019 .
`( Continued )
`
`Primary Examiner Md M Rahman
`( 74 ) Attorney , Agent , or Firm — Brooks Kushman P.C.
`
`( 57 )
`ABSTRACT
`A measurement system is provided with a light source that
`is configured to increase signal - to - noise ratio by increasing
`a light intensity from at least one of a plurality of semicon
`ductor sources . An apparatus to receive a portion of the
`output optical beam , and deliver an analysis output beam to
`a sample . A receiver to : receive and process at least a portion
`of the analysis output beam reflected or transmitted from the
`sample , generate an output signal , and synchronize to the
`light source . A smart phone or tablet to : receive and process
`at least a portion of the output signal , store and display the
`processed output signal , and transmit at least a portion of the
`processed output signal . A cloud to : receive an output status
`comprising the at least a portion of the processed output
`signal , process the received output status to generate pro
`cessed data , and store the processed data .
`
`27 Claims , 22 Drawing Sheets
`
`( 51 ) Int . Ci .
`GO1J 3/00
`A61B 5/00
`
`( 52 ) U.S. CI .
`CPC
`
`( 2006.01 )
`( 2006.01 )
`( Continued )
`
`A61B 5/0088 ( 2013.01 ) ; A61B 5/0013
`( 2013.01 ) ; A61B 5/0022 ( 2013.01 ) ;
`( Continued )
`( 58 ) Field of Classification Search
`CPC
`GO1J 3/02 ; GO1J 3/28 ; GO1J 3/42 ; GOIN
`21/31 ; GOIN 21/552
`
`( Continued )
`
`Case 1:25-cv-00140-JLH Document 1-4 Filed 02/03/25 Page 2 of 56 PageID #: 203
`
`SU
`
`980 KOMETER
`SCENER CERN
`
`TRANSMISSION
`STROMETER
`
`14
`
`

`

`US 10,874,304 B2
`Page 2
`
`Related U.S. Application Data
`continuation of application No. 16 / 016,649 , filed on
`Jun . 24 , 2018 , now Pat . No. 10,213,113 , which is a
`continuation of application No. 15 / 860,065 , filed on
`Jan. 2 , 2018 , now Pat . No. 10,098,546 , which is a
`continuation of application No. 15 / 686,198 , filed on
`Aug. 25 , 2017 , now Pat . No. 9,861,286 , which is a
`continuation of application No. 15 / 357,136 , filed on
`Nov. 21 , 2016 , now Pat . No. 9,757,040 , which is a
`continuation of application No. 14 / 651,367 , filed as
`application No. PCT / US2013 / 075736 on Dec. 17 ,
`2013 , now Pat . No. 9,500,635 , and application No.
`16 / 669,794 , which is a continuation of application
`No. 16 / 506,885 , filed on Jul . 9 , 2019 , now Pat . No.
`10,517,484 , which is a continuation of application
`No. 16 / 272,069 , filed on Feb. 11 , 2019 , now aban
`doned , which is a continuation of application No.
`16 / 029,611 , filed on Jul . 8 , 2018 , now Pat . No.
`10,201,283 , which is a continuation of application
`No. 15 / 888,052 , filed on Feb. 4 , 2018 , now Pat . No.
`10,136,819 , which is a continuation of application
`No. 15 / 212,549 , filed on Jul . 18 , 2016 , now Pat . No.
`9,885,698 , which is a continuation of application No.
`14 / 650,897 , filed as application No. PCT / US2013 /
`075700 on Dec. 17 , 2013 , now Pat . No. 9,494,567 ,
`said application No. 16 / 506,885 is a continuation of
`application No. 16 / 004,359 , filed on Jun . 9 , 2018 ,
`which is a continuation of application No. 14/109 ,
`007 , filed on Dec. 17 , 2013 , now Pat . No. 9,993,159 ,
`said application No. 16 / 506,885 is a continuation of
`application No. 16 / 188,194 , filed on Nov. 12 , 2018 ,
`now Pat . No. 10,386,230 , which is a continuation of
`application No. 16 / 004,154 , filed on Jun . 8 , 2018 ,
`now Pat . No. 10,126,283 , which is a continuation of
`application No. 15 / 855,201 , filed on Dec. 27 , 2017 ,
`now Pat . No. 9,995,722 , which is a continuation of
`application No. 15 / 711,907 , filed on Sep. 21 , 2017 ,
`now Pat . No. 9,897,584 , which is a division of
`application No. 15 / 357,225 , filed on Nov. 21 , 2016 ,
`now Pat . No. 9,797,876 , which is a continuation of
`application No. 14 / 650,981 , filed as application No.
`PCT / US2013 / 075767 on Dec. 17 , 2013 , now Pat . No.
`9,500,634 , said application No. 16 / 506,885 is a con
`tinuation of application No. 16 / 241,628 , filed on Jan.
`7 , 2019 , now Pat . No. 10,441,176 , which is a con
`tinuation of application No. 16 / 015,737 , filed on Jun .
`22 , 2018 , now Pat . No. 10,172,523 , which is a con
`tinuation of application No. 15 / 594,053 , filed on May
`12 , 2017 , now Pat . No. 10,188,299 , which is a con
`tinuation of application No. 14 / 875,709 , filed on Oct.
`6 , 2015 , now Pat . No. 9,651,533 , which is a continu
`ation of application No. 14 / 108,986 , filed on Dec. 17 ,
`2013 , now Pat . No. 9,164,032 , said application No.
`16 / 506,885 is a continuation of application No.
`16 / 284,514 , filed on Feb. 25 , 2019 , now abandoned ,
`which is a continuation of application No. 16/016 ,
`649 , filed on Jun . 24 , 2018 , now Pat . No. 10,213,113 ,
`which is a continuation of application No. 15/860 ,
`065 , filed on Jan. 2 , 2018 , now Pat . No. 10,098,546 ,
`which is a continuation of application No. 15/686 ,
`198 , filed on Aug. 25 , 2017 , now Pat . No. 9,861,286 ,
`which is a continuation of application No. 15/357 ,
`136 , filed on Nov. 21 , 2016 , now Pat . No. 9,757,040 ,
`which is a continuation of application No. 14/651 ,
`
`Case 1:25-cv-00140-JLH Document 1-4 Filed 02/03/25 Page 3 of 56 PageID #: 204
`
`367 , filed as application No. PCT / US2013 / 075736 on
`Dec. 17 , 2013 , now Pat . No. 9,500,635 .
`( 60 ) Provisional application No. 61 / 747,477 , filed on Dec.
`31 , 2012 , provisional application No. 61 / 754,698 ,
`filed on Jan. 12 , 2013 , provisional application No.
`61 / 747,472 , filed on Dec. 31 , 2012 , provisional
`application No. 61 / 747,553 , filed on Dec. 31 , 2012 ,
`provisional application No. 61 / 747,485 , filed on Dec.
`31 , 2012 , provisional application No. 61 / 747,487 ,
`filed on Dec. 31 , 2012 .
`( 51 ) Int . Ci .
`461C 19/04
`G16H 40/67
`A61B 5/145
`A61B 5/1455
`GO1J 3/02
`GO1J 3/10
`GO1J 3/14
`GO1J 3/28
`GO1J 3/42
`GO1J 3/453
`GOIN 2135
`GOIN 21/3563
`GOIN 21/359
`GOIN 21/39
`GOIN 21/88
`GOIN 33/02
`GOIN 33/15
`GOIN 33/44
`GOIN 33/49
`G06F 19/00
`HOIS 3/067
`HOIS 3/00
`461C 1700
`GO1J 3/18
`GO1J 3/12
`GOIM 3/38
`GOIN 21/85
`GOIN 21/95
`HOIS 3/30
`( 52 ) U.S. CI .
`CPC
`
`( 2006.01 )
`( 2018.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2014.01 )
`( 2014.01 )
`( 2014.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2018.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`
`A61B 5/0075 ( 2013.01 ) ; A61B 5/0086
`( 2013.01 ) ; A61B 5/1455 ( 2013.01 ) ; A61B
`5/14532 ( 2013.01 ) ; A61B 5/14546 ( 2013.01 ) ;
`A61B 5/4547 ( 2013.01 ) ; A61B 5/6801
`( 2013.01 ) ; A61B 5/7203 ( 2013.01 ) ; A61B
`5/7257 ( 2013.01 ) ; A61B 5/742 ( 2013.01 ) ;
`A61B 5/7405 ( 2013.01 ) ; A61C 19/04
`( 2013.01 ) ; GO1J 3/0218 ( 2013.01 ) ; G01J
`3/108 ( 2013.01 ) ; G01J 3/14 ( 2013.01 ) ; G01J
`3/28 ( 2013.01 ) ; GO1J 3/2823 ( 2013.01 ) ; G01J
`3/42 ( 2013.01 ) ; GOIJ 3/453 ( 2013.01 ) ; GOIN
`21/35 ( 2013.01 ) ; GOIN 21/359 ( 2013.01 ) ;
`GOIN 21/3563 ( 2013.01 ) ; GOIN 21/39
`( 2013.01 ) ; GOIN 21/88 ( 2013.01 ) ; GOIN
`33/02 ( 2013.01 ) ; GOIN 33/025 ( 2013.01 ) ;
`GOIN 33/15 ( 2013.01 ) ; GOIN 33/442
`( 2013.01 ) ; GOIN 33/49 ( 2013.01 ) ; G06F
`19/00 ( 2013.01 ) ; G16H 40/67 ( 2018.01 ) ; A61B
`5/0024 ( 2013.01 ) ; A61B 2562/0233 ( 2013.01 ) ;
`A61B 2562/0238 ( 2013.01 ) ; A61B 2562/146
`( 2013.01 ) ; A61B 2576/02 ( 2013.01 ) ; A61C
`1/0046 ( 2013.01 ) ; GOIJ 3/1838 ( 2013.01 ) ;
`GOIJ 2003/104 ( 2013.01 ) ; GOIJ 2003/1208
`
`

`

`US 10,874,304 B2
`Page 3
`
`( 56 )
`
`( 2013.01 ) ; GOIJ 2003/2826 ( 2013.01 ) ; GOIM
`3/38 ( 2013.01 ) ; GOIN 21/85 ( 2013.01 ) ; GOIN
`21/9508 ( 2013.01 ) ; GOIN 2021/3595
`( 2013.01 ) ; GOIN 2021/399 ( 2013.01 ) ; GOIN
`2201/061 ( 2013.01 ) ; GOIN 2201/062
`( 2013.01 ) ; GOIN 2201/06113 ( 2013.01 ) ; GOIN
`2201/08 ( 2013.01 ) ; GOIN 2201/12 ( 2013.01 ) ;
`GOIN 2201/129 ( 2013.01 ) ; HOIS 3/0092
`( 2013.01 ) ; HOIS 3706758 ( 2013.01 ) ; HOIS
`3/302 ( 2013.01 )
`( 58 ) Field of Classification Search
`356/300
`USPC
`See application file for complete search history .
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`Case 1:25-cv-00140-JLH Document 1-4 Filed 02/03/25 Page 4 of 56 PageID #: 205
`
`

`

`US 10,874,304 B2
`Page 4
`
`( 56 )
`
`Case 1:25-cv-00140-JLH Document 1-4 Filed 02/03/25 Page 5 of 56 PageID #: 206
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