Case 1:25-cv-00140-JLH Document 1-5 Filed 02/03/25 Page 1 of 159 PageID #: 258
`Case 1:25-cv-00140-JLH Document1-5
`Filed 02/03/25
`Page 1 of 159 PagelD #: 258
`
`EXHIBIT 5
`
`EXHIBIT 5
`
`

`

`( 12 ) United States Patent
`)
`Islam
`
`US 11,160,455 B2
`( 10 ) Patent No .:
`( 45 ) Date of Patent :
`* Nov . 2 , 2021
`
`US011160455B2
`
`( 54 )
`
`( * ) Notice :
`
`MULTI - WAVELENGTH WEARABLE DEVICE
`FOR NON - INVASIVE BLOOD
`MEASUREMENTS IN TISSUE
`( 71 ) Applicant : OMNI MEDSCI , INC . , Ann Arbor , MI
`( US )
`( 72 ) Inventor : Mohammed N. Islam , Ann Arbor , MI
`( US )
`( 73 ) Assignee : OMNI MEDSCI , INC . , Ann Arbor , MI
`( US )
`Subject to any disclaimer , the term of this
`patent is extended or adjusted under 35
`U.S.C. 154 ( b ) by 0 days .
`This patent is subject to a terminal dis
`claimer .
`( 21 ) Appl . No .: 17 / 078,771
`( 22 ) Filed :
`Oct. 23 , 2020
`( 65 )
`Prior Publication Data
`Feb. 11 , 2021
`US 2021/0038083 A1
`Related U.S. Application Data
`Continuation of application No. 16 / 722,188 , filed on
`Dec. 20 , 2019 , now Pat . No. 10,820,807 , which is a
`( Continued )
`
`( 60 )
`
`( 51 ) Int . Cl .
`GO1J 3/00
`A61B 5/00
`
`( 52 ) U.S. CI .
`CPC
`
`( 2006.01 )
`( 2006.01 )
`( Continued )
`
`A61B 5/0088 ( 2013.01 ) ; A61B 5/0013
`( 2013.01 ) ; A61B 5/0022 ( 2013.01 ) ;
`( Continued )
`( 58 ) Field of Classification Search
`GO1J 3/02 ; GO1J 3/28 ; G01J 3/42 ; GOIN
`CPC
`21/31 ; GOIN 21/552
`
`( Continued )
`
`Case 1:25-cv-00140-JLH Document 1-5 Filed 02/03/25 Page 2 of 159 PageID #: 259
`
`2103
`
`2107 2108
`
`2104
`
`- 022
`
`2101
`
`2110
`
`2109
`
`PRE - AMP
`
`2102
`
`( 56 )
`
`CA
`CN
`
`References Cited
`U.S. PATENT DOCUMENTS
`4,063,106 A
`4,158,750 A
`
`12/1977 Ashkin et al .
`6/1979 Sakoe et al .
`( Continued )
`FOREIGN PATENT DOCUMENTS
`
`9/2004
`2458123 A1
`101849821 A 10/2010
`( Continued )
`
`OTHER PUBLICATIONS
`
`Inter Partes Review No. IPR2021-00453 ; Petition for Inter Partes
`Review of U.S. Pat . No. 10,517,484 ; Apple Inc. v . Omni Medsci ,
`Inc .; pp . 1-103 ; dated Jan. 22 , 2021 .
`( Continued )
`Primary Examiner Md M Rahman
`( 74 ) Attorney , Agent , or Firm - Brooks Kushman P.C.
`
`a
`
`ABSTRACT
`( 57 )
`A system for measuring one or more physiological param
`eters is provided with a wearable device that includes a light
`source comprising a driver and a plurality of semiconductor
`sources that generate an output optical light . The wearable
`device comprises : one or more lenses to receive at least a
`portion of the output optical light and to deliver a lens output
`light to tissue , and a detection system to receive at least a
`portion of the lens output light reflected from the tissue and
`to generate an output signal having a signal - to - noise ratio ,
`and to be synchronized to the light source . The detection
`system comprises at least one analog to digital converter
`coupled to at least one spatially separated detector . The
`plurality of semiconductor sources comprises six light emit
`ting diodes , and wherein the plurality of semiconductor
`sources and the plurality of spatially separated detectors are
`located on one or more arcs .
`20 Claims , 100 Drawing Sheets
`
`2100
`
`2111
`
`2113
`
`2112
`
`MO
`
`2115
`
`POWER - AMP
`
`2106
`
`

`

`US 11,160,455 B2
`Page 2
`
`2
`
`9
`
`Related U.S. Application Data
`continuation of application No. 16 / 506,885 , filed on
`Jul . 9 , 2019 , now Pat . No. 10,517,484 , which is a
`continuation of application No. 16 / 272,069 , filed on
`Feb. 11 , 2019 , now abandoned , which is a continu
`a
`ation of application No. 16 / 029,611 , filed on Jul . 8 ,
`2018 , now Pat . No. 10,201,283 , which is a continu
`ation of application No. 15 / 888,052 , filed on Feb. 4 ,
`2018 , now Pat . No. 10,136,819 , which is a continu
`ation of application No. 15 / 212,549 , filed on Jul . 18 ,
`016 , now Pat . No. 9,885,698 , which is a continu
`ation of application No. 14 / 650,897 , filed as applica
`tion No. PCT / IS2013 / 075700 on Dec. 17 , 2013 , now
`Pat . No. 9,494,567 , said application No. 16 / 506,885
`is a continuation of application No. 16 / 004,359 , filed
`on Jun . 9 , 2018 , which is a continuation of application
`a
`No. 14 / 109,007 , filed on Dec. 17 , 2013 , now Pat . No.
`9,993,159 , said application No. 16 / 506,885 is a con
`tinuation of application No. 16 / 188,194 , filed on Nov.
`12 , 2018 , now Pat . No. 10,386,230 , which is a con
`tinuation of application No. 16 / 004,154 , filed on Jun .
`8 , 2018 , now Pat . No. 10,126,283 , which is a con
`tinuation of application No. 15 / 855,201 , filed on Dec.
`27 , 2017 , now Pat . No. 9,995,722 , which is a con
`tinuation of application No. 15 / 711,907 , filed on Sep.
`21 , 2017 , now Pat . No. 9,897,584 , which is a division
`a
`of application No. 15 / 357,225 , filed on Nov. 21 , 2016 ,
`now Pat . No. 9,797,876 , which is a continuation of
`application No. 14 / 650,981 , filed as application No.
`PCT / US2013 / 075767 on Dec. 17 , 2013 , now Pat . No.
`9,500,634 , said application No. 16 / 506,885 is a con
`tinuation of application No. 16 / 241,628 , filed on Jan.
`7 , 2019 , now Pat . No. 10,441,176 , which is a contin
`uation of application No. 16 / 015,737 , filed on Jun . 22 ,
`2018 , now Pat . No. 10,172,523 , which is a continu
`ation of application No. 15 / 594,053 , filed on May 12 ,
`2017 , now Pat . No. 10,188,299 , which is a continu
`ation of application No. 14 / 875,709 , filed on Oct. 6 ,
`2015 , now Pat . No. 9,651,533 , which is a continu
`ation of application No. 14 / 108,986 , filed on Dec. 17 ,
`2013 , now Pat . No. 9,164,032 , said application No.
`16 / 506,885 is a continuation of application No.
`16 / 284,514 , filed on Feb. 25 , 2019 , now abandoned ,
`which is a continuation of application No. 16/016 ,
`649 , filed on Jun . 24 , 2018 , now Pat . No. 10,213,113 ,
`which is a continuation of application No. 15/860 ,
`065 , filed on Jan. 2 , 2018 , now Pat . No. 10,098,546 ,
`which is a continuation of application No. 15/686 ,
`198 , filed on Aug. 25 , 2017 , now Pat . No. 9,861,286 ,
`which is a continuation of application No. 15/357 ,
`136 , filed on Nov. 21 , 2016 , now Pat . No. 9,757,040 ,
`which is a continuation of application No. 14/651 ,
`367 , filed as application No. PCT / US2013 / 075736 on
`Dec. 17 , 2013 , now Pat . No. 9,500,635 .
`
`( 60 ) Provisional application No. 61 / 747,472 , filed on Dec.
`31 , 2012 , provisional application No. 61 / 747,553 ,
`filed on Dec. 31 , 2012 , provisional application No.
`61 / 747,485 , filed on Dec. 31 , 2012 , provisional
`application No. 61 / 747,487 , filed on Dec. 31 , 2012 ,
`provisional application No. 61 / 747,477 , filed on Dec.
`31 , 2012 , provisional application No. 61 / 754,698 ,
`filed on Jan. 21 , 2013 .
`
`2
`
`2
`
`Case 1:25-cv-00140-JLH Document 1-5 Filed 02/03/25 Page 3 of 159 PageID #: 260
`
`( 51 ) Int . Cl .
`A61B 5/145
`A61B 5/1455
`G16H 40/67
`G06F 19/00
`GO1J 3/02
`GO1J 3/10
`GO1J 3/14
`GO1J 3/28
`GO1J 3/42
`GOIJ 3/453
`GOIN 21/35
`GOIN 21/3563
`GOIN 21/359
`GOIN 21/39
`GOIN 21/88
`GOIN 33/02
`GOIN 33/15
`GOIN 33/44
`GOIN 33/49
`GO1J 3/18
`GO1J 3/12
`GOIM 3/38
`GOIN 21/85
`GOIN 21/95
`HOIS 3/00
`HOIS 3/067
`HOIS 3/30
`( 52 ) U.S. CI .
`CPC
`
`( 2006.01 )
`( 2006.01 )
`( 2018.01 )
`( 2018.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2014.01 )
`( 2014.01 )
`( 2014.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`( 2006.01 )
`
`A61B 5/0075 ( 2013.01 ) ; A61B 5/0086
`( 2013.01 ) ; A61B 5/1455 ( 2013.01 ) ; A61B
`5/14532 ( 2013.01 ) ; A61B 5/14546 ( 2013.01 ) ;
`A61B 5/4547 ( 2013.01 ) ; A61B 5/6801
`( 2013.01 ) ; A61B 5/7257 ( 2013.01 ) ; A61B
`5/742 ( 2013.01 ) ; A61B 5/7405 ( 2013.01 ) ;
`GO1J 3/0218 ( 2013.01 ) ; GOIJ 3/108
`( 2013.01 ) ; GOIJ 3/14 ( 2013.01 ) ; G01J 3/28
`( 2013.01 ) ; G01J 3/2823 ( 2013.01 ) ; GOIJ 3/42
`( 2013.01 ) ; G01J 3/453 ( 2013.01 ) ; GOIN 21/35
`( 2013.01 ) ; GOIN 21/359 ( 2013.01 ) ; GOIN
`21/3563 ( 2013.01 ) ; GOIN 21/39 ( 2013.01 ) ;
`GOIN 21/88 ( 2013.01 ) ; GOIN 33/02
`( 2013.01 ) ; GOIN 33/025 ( 2013.01 ) ; GOIN
`33/15 ( 2013.01 ) ; GOIN 33/442 ( 2013.01 ) ;
`GOIN 33/49 ( 2013.01 ) ; G06F 19/00
`( 2013.01 ) ; G16H 40/67 ( 2018.01 ) ; A61B
`2562/0233 ( 2013.01 ) ; A61B 2562/0238
`( 2013.01 ) ; A61B 2562/146 ( 2013.01 ) ; A61B
`2576/02 ( 2013.01 ) ; GOIJ 3/1838 ( 2013.01 ) ;
`GOIJ 2003/104 ( 2013.01 ) ; GOIJ 2003/1208
`( 2013.01 ) ; GOIJ 2003/2826 ( 2013.01 ) ; GOIM
`3/38 ( 2013.01 ) ; GOIN 21/85 ( 2013.01 ) ; GOIN
`21/9508 ( 2013.01 ) ; GOIN 2021/3595
`( 2013.01 ) ; GOIN 2021/399 ( 2013.01 ) ; GOIN
`2201/061 ( 2013.01 ) ; GOIN 2201/062
`( 2013.01 ) ; GOIN 2201/06113 ( 2013.01 ) ; GOIN
`2201/08 ( 2013.01 ) ; GOIN 2201/12 ( 2013.01 ) ;
`GOIN 2201/129 ( 2013.01 ) ; HOIS 3/0092
`( 2013.01 ) ; HOIS 3/06758 ( 2013.01 ) ; HOIS
`3/302 ( 2013.01 ) ; YO2A 90/10 ( 2018.01 )
`( 58 ) Field of Classification Search
`USPC
`356/300
`See application file for complete search history .
`
`

`

`( 56 )
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`
`Case 1:25-cv-00140-JLH Document 1-5 Filed 02/03/25 Page 4 of 159 PageID #: 261
`
`US 11,160,455 B2
`Page 3
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