Case 1:25-cv-00140-JLH Document1-6
`Filed 02/03/25
`Page 1 of 148 PagelD #: 417
`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 1 of 148 PageID #: 417
`
`EXHIBIT 6
`
`EXHIBIT 6
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 2 of 148 PageID #: 418
`I 1111111111111111 111111111111111 lllll lllll 111111111111111 111111111111111111
`US012193790B2
`
`c12) United States Patent
`Islam
`
`(IO) Patent No.: US 12,193,790 B2
`(45) Date of Patent:
`*Jan. 14, 2025
`
`(54) WEARABLE DEVICES COMPRISING
`SEMICONDUCTOR DIODE LIGHT
`SOURCES WITH IMPROVED
`SIGNAL-TO-NOISE RATIO
`
`(71) Applicant: OMNI MEDSCI, INC., Ann Arbor, MI
`(US)
`
`(72)
`
`Inventor: Mohammed N. Islam, Ann Arbor, MI
`(US)
`
`(73) Assignee: OMNI MEDSCI, INC., Ann Arbor, MI
`(US)
`
`( *) Notice:
`
`Subject to any disclaimer, the term ofthis
`patent is extended or adjusted under 35
`U.S.C. 154(b) by O days.
`
`This patent is subject to a terminal dis(cid:173)
`claimer.
`
`(21) Appl. No.: 18/438,144
`
`(22) Filed:
`
`Feb. 9, 2024
`
`(65)
`
`Prior Publication Data
`
`US 2024/0180428 Al
`
`Jun. 6, 2024
`
`Related U.S. Application Data
`
`(60) Continuation of application No. 18/103,408, filed on
`Jan. 30, 2023, now Pat. No. 11,896,346, which is a
`(Continued)
`
`(51)
`
`Int. Cl.
`A61B 5100
`A61B 51145
`
`(2006.01)
`(2006.01)
`(Continued)
`
`(52) U.S. Cl.
`CPC .......... A61B 510088 (2013.01); A61B 510013
`(2013.01); A61B 510022 (2013.01);
`(Continued)
`(58) Field of Classification Search
`CPC ................ A61B 5/0088; A61B 5/0013; A61B
`5/0022; A61B 5/0075; A61B 5/0086;
`(Continued)
`References Cited
`
`(56)
`
`U.S. PATENT DOCUMENTS
`
`9,430,093 B2 *
`9,915,726 B2 *
`
`8/2016 Harrison ............... G06F 3/0421
`3/2018 Bailey ................... G0lS 7/4814
`
`* cited by examiner
`Primary Examiner - Md M Rahman
`(74) Attorney, Agent, or Firm - Brooks Kushman P.C.
`ABSTRACT
`(57)
`An optical system comprises a wearable device for measur(cid:173)
`ing one or more physiological parameters. The physiological
`parameters may change in response to stretching of the hand
`or movement of fingers or thumb of the user, or the param(cid:173)
`eters may be related to blood constituents or blood flow. The
`wearable device comprises a light source with a plurality of
`semiconductor diodes and a detection system that measures
`reflected light from tissue comprising skin. The semicon(cid:173)
`ductor diodes may be light emitting diodes or laser diodes.
`The signal to noise ratio for the output signal may be
`improved by synchronizing the detection system to the light
`source, increasing light intensity of at least one of the
`plurality of semiconductor diodes from an initial light inten(cid:173)
`sity, and using change detection that compares light on
`versus light off for the detection system output. The wear(cid:173)
`able device is also configured to identify an object.
`20 Claims, 100 Drawing Sheets
`
`2100
`I
`
`f········
`2114
`2
`
`2103
`2107 2100
`,.
`1 I
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`,,
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`• ••••. ~·-·:;_.>··-!-·····+~
`'
`{ ~ I
`
`21\l}
`
`/
`2109
`
`2102
`
`POWER-AMP
`
`2100
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 3 of 148 PageID #: 419
`
`US 12,193,790 B2
`Page 2
`
`Related U.S. Application Data
`
`continuation of application No. 17/514,778, filed on
`Oct. 29, 2021, now Pat. No. 11,564,577, which is a
`continuation of application No. 17/078,771, filed on
`Oct. 23, 2020, now Pat. No. 11,160,455, which is a
`continuation of application No. 16/722,188, filed on
`Dec. 20, 2019, now Pat. No. 10,820,807, which is a
`continuation of application No. 16/506,885, filed on
`Jul. 9, 2019, now Pat. No. 10,517,484, which is a
`continuation of application No. 16/284,514, filed on
`Feb. 25, 2019, now abandoned, and a continuation of
`application No. 16/272,069, filed on Feb. 11, 2019,
`now abandoned, and a continuation of application No.
`16/241,628, filed on Jan. 7, 2019, now Pat. No.
`10,441,176, and a continuation of application No.
`16/188,194, filed on Nov. 12, 2018, now Pat. No.
`10,386,230, said application No. 16/272,069 is a
`continuation of application No. 16/029,611, filed on
`Jul. 8, 2018, now Pat. No. 10,201,283, said applica(cid:173)
`tion No. 16/284,514 is a continuation of application
`No. 16/016,649, filed on Jun. 24, 2018, now Pat. No.
`10,213,113, said application No. 16/241,628 is a
`continuation of application No. 16/015,737, filed on
`Jun. 22, 2018, now Pat. No. 10,172,523, said appli(cid:173)
`cation No. 16/506,885 is a continuation of application
`No. 16/004,359, filed on Jun. 9, 2018, now Pat. No.
`11,109,761, said application No. 16/188,194 is a
`continuation of application No. 16/004,154, filed on
`Jun. 8, 2018, now Pat. No. 10,126,283, said applica(cid:173)
`tion No. 16/029,611 is a continuation of application
`No. 15/888,052, filed on Feb. 4, 2018, now Pat. No.
`10,136,819, said application No. 16/016,649 is a
`continuation of application No. 15/860,065, filed on
`Jan. 2, 2018, now Pat. No. 10,098,546, said applica(cid:173)
`tion No. 16/004,154 is a continuation of application
`No. 15/855,201, filed on Dec. 27, 2017, now Pat. No.
`9,995,722, which is a continuation of application No.
`15/711,907, filed on Sep. 21, 2017, now Pat. No.
`9,897,584, said application No. 15/860,065 is a con(cid:173)
`tinuation of application No. 15/686,198, filed on Aug.
`25, 2017, now Pat. No. 9,861,286, said application
`No. 16/015,737 is a continuation of application No.
`15/594,053, filed on May 12, 2017, now Pat. No.
`10,188,299, said application No. 15/711,907 is a
`division of application No. 15/357,225, filed on Nov.
`21, 2016, now Pat. No. 9,797,876, said application
`No. 15/686,198 is a continuation of application No.
`15/357,136, filed on Nov. 21, 2016, now Pat. No.
`9,757,040, said application No. 15/888,052 is a con(cid:173)
`tinuation of application No. 15/212,549, filed on Jul.
`18, 2016, now Pat. No. 9,885,698, said application
`No. 15/594,053 is a continuation of application No.
`14/875,709, filed on Oct. 6, 2015, now Pat. No.
`9,651,533, said application No. 15/357,136 is a con(cid:173)
`tinuation of application No. 14/651,367, filed as
`application No. PCT/US2013/075736 on Dec. 17,
`2013, now Pat. No. 9,500,635, said application No.
`15/357,225 is a continuation of application No.
`14/650,981, filed on Jun. 10, 2015, now Pat. No.
`9,500,634, said application No. 15/212,549 is a con(cid:173)
`tinuation of application No. 14/650,897, filed as
`application No. PCT/US2013/075700 on Dec. 17,
`2013, now Pat. No. 9,494,567, said application No.
`16/004,359 is a continuation of application No.
`14/109,007, filed on Dec. 17, 2013, now Pat. No.
`
`(60)
`
`(51)
`
`(52)
`
`9,993,159, said application No. 14/875,709 is a con(cid:173)
`tinuation of application No. 14/108,986, filed on Dec.
`17, 2013, now Pat. No. 9,164,032.
`
`Provisional application No. 61/754,698, filed on Jan.
`21, 2013, provisional application No. 61/747,477,
`filed on Dec. 31, 2012, provisional application No.
`61/747,472, filed on Dec. 31, 2012, provisional
`application No. 61/747,487, filed on Dec. 31, 2012,
`provisional application No. 61/747,553, filed on Dec.
`31, 2012.
`
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2014.01)
`(2014.01)
`(2014.01)
`(2014.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2018.01)
`(2019.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`
`Int. Cl.
`A61B 511455
`A61C 19104
`GOJJ 3102
`GOJJ 3/10
`GOJJ 3/14
`GOJJ 3/28
`GOJJ 3/42
`GOJJ 3/453
`GOIN 21135
`GOIN 2113504
`GOIN 2113563
`GOIN 211359
`GOIN 21139
`GOIN 21188
`GOIN 33102
`GOIN 33115
`GOIN 33/44
`GOIN 33/49
`G16H 40167
`G16Z 99/00
`A61C 1/00
`GOJJ 3/12
`GOJJ 3/18
`GOJM 3/38
`GOIN 21/85
`GOIN 21/95
`HOJS 3/00
`HOJS 3/067
`HOJS 3/30
`U.S. Cl.
`CPC .......... A61B 510075 (2013.01); A61B 510086
`(2013.01); A61B 5114532 (2013.01); A61B
`5114546 (2013.01); A61B 511455 (2013.01);
`A61B 514547 (2013.01); A61B 516801
`(2013.01); A61B 517203 (2013.01); A61B
`517257 (2013.01); A61B 517405 (2013.01);
`A61B 51742 (2013.01); A61C 19104 (2013.01);
`GOJJ 3102 (2013.01); GOJJ 310218 (2013.01);
`GOJJ 3/108 (2013.01); GOJJ 3/14 (2013.01);
`GOJJ 3/28 (2013.01); GOJJ 3/2823 (2013.01);
`GOJJ 3/42 (2013.01); GOJJ 3/453 (2013.01);
`GOIN 21135 (2013.01); GOIN 2113504
`(2013.01); GOIN 2113563 (2013.01); GOIN
`211359 (2013.01); GOIN 21139 (2013.01);
`GOIN 21188 (2013.01); GOIN 33102
`(2013.01); GOIN 331025 (2013.01); GOIN
`33115 (2013.01); GOIN 33/442 (2013.01);
`GOIN 33/49 (2013.01); G16H 40167
`(2018.01); G16Z 99/00 (2019.02); A61B
`5/0024 (2013.01); A61B 2562/0233 (2013.01);
`A61B 2562/0238 (2013.01); A61B 2562/146
`(2013.01); A61B 2576/02 (2013.01); A61C
`1/0046 (2013.01); GOJJ 2003/104 (2013.01);
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 4 of 148 PageID #: 420
`
`US 12,193,790 B2
`Page 3
`
`GOJJ 2003/1208 (2013.01); GOJJ 3/1838
`(2013.01); GOJJ 2003/2826 (2013.01); GOJM
`3/38 (2013.01); GOIN 2021/3513 (2013.01);
`GOIN 2021/3595 (2013.01); GOIN 2021/399
`(2013.01); GOIN 21/85 (2013.01); GOIN
`21/9508 (2013.01); GOIN 2201/061 (2013.01);
`GOIN 2201/06113 (2013.01); GOIN 2201/062
`(2013.01); GOIN 2201/08 (2013.01); GOIN
`2201/12 (2013.01); GOIN 2201/129 (2013.01);
`HOJS 3/0092 (2013.01); HOJS 3/06758
`(2013.01); HOJS 3/302 (2013.01); Y02A 90/10
`(2018.01)
`
`( 58) Field of Classification Search
`CPC ............ A61B 5/14532; A61B 5/14546; A61B
`5/1455; A61B 5/4547; A61B 5/6801;
`A61B 5/7203; A61B 5/7257; A61B
`5/7405; A61B 5/742; A61B 5/0024; A61B
`2562/0233; A61B 2562/0238; A61B
`2562/146; A61B 2576/02; A61B 5/682;
`A61C 19/04; A61C 1/0046; GOU 3/02;
`GOU 3/0218; GOU 3/108; GOU 3/14;
`
`GOU 3/28; GOU 3/2823; GOU 3/42;
`GOU 3/453; GOU 3/1838; GOU
`2003/104; GOU 2003/1208; GOU
`2003/2826; GOIN 21/35; GOIN 21/3504;
`GOIN 21/3563; GOIN 21/359; GOIN
`21/39; GOIN 21/88; GOIN 33/02; GOIN
`33/025; GOIN 33/15; GOIN 33/442;
`GOIN 33/49; GOIN 21/85; GOIN
`21/9508; GOIN 2021/3513; GOIN
`2021/3595; GOIN 2021/399; GOIN
`2201/061; GOIN 2201/06113; GOIN
`2201/062; GOIN 2201/08; GOIN
`2201/12; GOIN 2201/129; GOIN 21/474;
`GOIN 2201/0221; GOIN 2021/1789;
`GOIN 2201/0626; GOIN 2201/0627;
`G16H 40/67; G16H 40/63; G16H 50/20;
`G16Z 99/00; GOlM 3/38; HOlS 3/0092;
`HOlS 3/06758; HOlS 3/302; Y02A 90/10
`USPC .......................................................... 356/300
`See application file for complete search history.
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 5 of 148 PageID #: 421
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 1 of 100
`
`US 12,193,790 B2
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`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 6 of 148 PageID #: 422
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`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 7 of 148 PageID #: 423
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 3 of 100
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`US 12,193,790 B2
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`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 8 of 148 PageID #: 424
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 4 of 100
`
`US 12,193,790 B2
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`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 9 of 148 PageID #: 425
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 5 of 100
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`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 10 of 148 PageID #:
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`U.S. Patent
`
`Jan.14,2025
`
`Sheet 6 of 100
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`US 12,193,790 B2
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`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 11 of 148 PageID #:
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`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 12 of 148 PageID #:
`428
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 8 of 100
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`US 12,193,790 B2
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`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 13 of 148 PageID #:
`429
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`U.S. Patent
`
`Jan.14,2025
`
`Sheet 9 of 100
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`US 12,193,790 B2
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`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 14 of 148 PageID #:
`430
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 10 of 100
`
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`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 26 of 148 PageID #:
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`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 36 of 148 PageID #:
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`Jan.14,2025
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`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 37 of 148 PageID #:
`453
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 33 of 100
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`US 12,193,790 B2
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`100
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`600
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`1600
`1800
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`FlG. 26A
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 38 of 148 PageID #:
`454
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 34 of 100
`
`US 12,193,790 B2
`
`600
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`500
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`1
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`aoo--__.. ______ _.
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`
`FIG. 268
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 39 of 148 PageID #:
`455
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 35 of 100
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`US 12,193,790 B2
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`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 40 of 148 PageID #:
`456
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 36 of 100
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`US 12,193,790 B2
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`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 41 of 148 PageID #:
`457
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 37 of 100
`
`US 12,193,790 B2
`
`LIGHT
`INPUT
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`DETECTOR
`OUTPUT
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`2007
`
`2900
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`
`2901
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 42 of 148 PageID #:
`458
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 38 of 100
`
`US 12,193,790 B2
`
`3000
`I
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`LIGHT
`INPUT
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`DETECTOR
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`FIGg 30
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`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 43 of 148 PageID #:
`459
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`3100
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`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 44 of 148 PageID #:
`460
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 40 of 100
`
`US 12,193,790 B2
`
`3200
`I
`
`OH
`COMS!NAT!ONS
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`FIG. 32
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 45 of 148 PageID #:
`461
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 41 of 100
`
`US 12,193,790 B2
`
`3300
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`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 46 of 148 PageID #:
`462
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 42 of 100
`
`US 12,193,790 B2
`
`C2H5
`
`3350
`I
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`FIG. 338
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 47 of 148 PageID #:
`463
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 43 of 100
`
`US 12,193,790 B2
`
`3400
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`to
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`0,5
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`O;O ............ ~1-l-,..lc......l......l"--l2~~L..,.;3 .............. ~,.__,4....... ,,.__._........,_,L....,.15
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`WAVELENGTH (µm)
`FIG.34
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 48 of 148 PageID #:
`464
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 44 of 100
`
`US 12,193,790 B2
`
`3500
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`3501
`I
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`SURFACE ALTERATIONS
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`
`FIG. 35B
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 49 of 148 PageID #:
`465
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 45 of 100
`
`US 12,193,790 B2
`
`0,36
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`FIG. 36A
`
`2.3
`
`2.4
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 50 of 148 PageID #:
`466
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 46 of 100
`
`US 12,193,790 B2
`
`3650
`I
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`FIG. 36B
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`2.0
`
`2,5
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 51 of 148 PageID #:
`467
`
`U.S. Patent
`
`Jan. 14,2025
`
`Sheet 47 of 100
`
`US 12,193,790 B2
`
`3700
`✓
`
`0,5
`
`to
`
`2.0
`
`t5
`WAVELENGTH {p,m)
`
`FIG. 37
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 52 of 148 PageID #:
`468
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 48 of 100
`
`US 12,193,790 B2
`
`VISIBLE
`
`NEAR INFRARED
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`WAVELENGTH {µm}
`FIG. 38
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 53 of 148 PageID #:
`469
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 49 of 100
`
`US 12,193,790 B2
`
`3900
`I
`
`CHLOROPHYLL
`
`CELL STRUCTURE
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`WATER
`
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`60
`
`20
`
`OA
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`0.8
`
`1.0
`
`1.2
`
`2.0
`
`2,2
`
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`
`1.6
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`(µm)
`FIG. 39
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 54 of 148 PageID #:
`470
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 50 of 100
`
`US 12,193,790 B2
`
`4000
`I
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`4002
`
`4007
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`
`FIG. 40
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 55 of 148 PageID #:
`471
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 51 of 100
`
`US 12,193,790 B2
`
`4100
`I
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`4101 <
`
`,..-~,(/-,.,.~,i'c.(,t~':>1',~»~,...,,.oN~,~ ,,,.v.,,.,_4_...._. .. ,.. .... (- .,,.~),*•""~..: ,,...,.~,. .__.., ;,.~.::,·,,1,,-.-, ,._~,
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`WAVELENGTH (µm}
`FIG. 41
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 56 of 148 PageID #:
`472
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 52 of 100
`
`US 12,193,790 B2
`
`0000
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`2,0
`
`to
`
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`t67
`
`FIG« 42
`
`5000.
`
`2,0
`
`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 57 of 148 PageID #:
`473
`
`U.S. Patent
`
`Jan.14,2025
`
`Sheet 53 of 100
`
`US 12,193,790 B2
`
`4300
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`
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`FIG. 43
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`

`

`Case 1:25-cv-00140-JLH Document 1-6 Filed 02/03/25 Page 58 of 148 PageID #:
`474
`
`CH3
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