Paramjit Arora
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`
`
` Date of Birth: November 23, 1970
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`Curriculum Vitae: Paramjit S. Arora
`
`Phone: (212) 998-8470
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` Department of Chemistry
`Email: arora@nyu.edu
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` New York University
`Web page: http://chemistry.fas.nyu.edu/object/paramjitarora.html
`New York, NY 10003
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`Personal
`US Citizen
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`Education & Professional Experience
`B.S. in Chemistry: University of California at Berkeley (1993).
`Research Advisors: Professor Richard Mathies (Department of Chemistry) and Professor
`Alexander Glazer (Department of Molecular Biology): Design and synthesis of DNA-
`binding fluorescent dyes for FRET studies.
`Ph.D. in Chemistry: University of California at Irvine (1999).
`Research Advisors: Professor James Nowick and Professor Michael Famulok (University
`of Bonn): Development of RNA catalysts for organic reactions.
`Postdoctoral in Bioorganic Chemistry: California Institute of Technology (1999-2002).
`Research Advisor: Professor Peter B. Dervan: Regulation of gene expression by N-
`methylpyrrole, N-methylimidazole polyamides: cellular uptake of polyamides and
`peptide-polyamide conjugates as artificial transcriptional activators.
`Assistant Professor of Chemistry: New York University (Fall 2002-2008)
`Associate Professor of Chemistry: New York University (2008-2012)
`Professor of Chemistry: New York University (2012-present)
`Research Interests: Design of peptidomimetics, recognition of nucleic acids by small
`molecules, and disruption of protein-protein interactions.
`Faculty: New York University School of Medicine Sackler Institute of Graduate Biomedical
`Sciences (2008-present)
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`Awards and Honors
`2011
`Eppley Visiting Professor of Oncology, University of Nebraska-Eppley Institute
`2009 –
`Faculty Member, Faculty of 1000-Chemical Biology
`2007
`Golden Dozen Award for Outstanding Teaching
`2006
`U.S. delegate, First Joint Conference of American Chemical Society & Indian Council
`of Scientific & Industrial Research
`2006
`Inaugural American Chemical Society ORG Young Investigator Symposium Award
`2005 Whitehead Fellowship for Young Faculty in Biomedicine
`2005
`Research Corporation Cottrell Scholar Award
`2005
`NSF CAREER Award (declined)
`2005
`Goddard Junior Faculty Fellowship
`2003
`James D. Watson Investigator Award
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`Paramjit Arora
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`American Cancer Society Postdoctoral Fellow
`1999
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`Publications
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`43.
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`Raj, M.; Wu, H.; Vittoria, M.; Arora, P. S. “Aldehyde Capture Ligation for Synthesis of
`Native Peptide Bonds.” Under review at Nature Communications.
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`Lao, B. B.; Drew, K.; Guarracino, D.; Brewer, T.; Heindel, D.; Bonneau, R.; Arora, P. S.
`"Oligooxopiperazines as Rationally Designed Small Molecule Inhibitors of Helical
`Protein-Protein Interactions." Submitted.
`
`Kushal, S.; Lao, B. B.; Henchey, L. K.; Dubey, R. Mesallati, H.; Traaseth, N. J.;
`Olenyuk, B. Z.; Arora, P. S. “Protein Domain Mimetics as In Vivo Modulators of
`Hypoxia-Inducible Factor Signaling.” Proc. Natl. Acad. Sci. U. S. A. 2013, 110,
`Accepted.
`Xie, X.; Piao, L.; Bullock, B. N.; Smith, A.; Su, T.; Zhang, M.; Teknos, T. N.; Arora, P.
`S.; Pan, Q. Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the
`tumorigenicity of HPV-positive head and neck squamous cell carcinoma. Oncogene
`2013, 32, Advanced online publication.
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`42.
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`Raj, M.; Bullock, B. N.; Arora, P. S. Plucking the high hanging fruit: A systematic
`approach for targeting protein-protein interactions. Bioorg. Med. Chem. 2013, 21, 4051-
`4057.
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`38. Wang, X.; Bergenfeld, I.; Arora, P. S.; Canary, J. W. “Reversible Redox-Reconfiguration
`of Secondary Structures in a Designed Peptide.” Angew. Chem. Int. Ed. 2012, 51, 12099-
`12101.
`Patgiri, A.; Joy, S. T.; Arora, P. S. “Nucleation Effects in Peptide Foldamers” J. Am.
`Chem. Soc. 2012, 112, 11495-11502.
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`37.
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`36. Mahon, A. B.; Arora, P. S. "Design, Synthesis and Protein-Targeting properties of
`thioether-linked hydrogen bond surrogate helices." Chem. Commun. 2012, 48, 1416–
`1418. (Invited Article for the Emerging Investigators issue)
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`35. Miller, S. E.; Kallenbach, N. R.; Arora, P. S. “Reversible α-Helix Formation Controlled
`By A Hydrogen Bond Surrogate.” Tetrahedron 2012, 68, 4434-4437. (Invited article for
`a special issue on Foldamers)
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`34. Mahon, A. B.; Miller, S. E.; Joy, S. T.; Arora, P. S.: Rational Design Strategies for
`Developing Synthetic Inhibitors of Helical Protein Interfaces In Protein-Protein
`Interactions; Wendt, M. D., Ed.; Springer, 2012; pp 175. (Book chapter)
`
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`33. Mahon, A. B.; Arora, P. S. “End-capped α-helices as modulators of protein function.”
`Drug Discovery Today: Technologies 2012, 9, e57-e62. (Invited review)
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`Bullock, B. N.; Jochim, A. L.; Arora, P. S. “Assessing Helical Protein Interfaces for
`Inhibitor Design.” J. Am. Chem. Soc. 2011, 133, 14220-14223.
`
`Patgiri, A.; Yadav, K.; Arora, P. S.; Bar-Sagi, D. “An Orthosteric Inhibitor of the Ras–
`Sos Interface.” Nature Chem. Biol. 2011, 7, 585-587.
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`Guarracino, D. A.; Bullock, B. N.; Arora, P. S. “Protein-Protein Interactions in
`Transcription: A Fertile Ground for Helix Mimetics.” Biopolymers 2011, 95, 1-7. (Invited
`review)
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`Jochim, A. L.; Arora P. S. “Systematic Analysis of Helical Protein Interfaces Reveals
`Targets for Synthetic Inhibitors.” ACS Chem. Biol. 2010, 5, 919-923.
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`Patgiri, A.; Menzenski, M. Z.; Mahon, A. B. “Solid Phase Synthesis of Short α-Helices
`Stabilized by the Hydrogen Bond Surrogate Approach.” Nature Protocols 2010, 5, 1857-
`1865.
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`Porter, J. R.; Helmers, M. R.; Wang, P.; Furman, J. L.; Joy, S. T.; Arora, P. S.; Ghosh, I.
`“Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family
`inhibitor BH3I-1 potently inhibits p53/hDM2” Chem. Commun. 2010, 46, 8020-8022.
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`Tošovská, P.; Arora, P. S. "Oligooxopiperazines as Nonpeptidic α-Helix Mimetics.” Org.
`Lett. 2010, 12, 1588-1591.
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`Henchey, L. K.; Porter, J. R.; Ghosh, I.; Arora, P. S. “High Specificity in Protein
`Recognition by Hydrogen Bond Surrogate α-Helices: Selective Inhibition of the
`p53/MDM2 Complex.” ChemBiochem 2010, 11, 2104-2107.
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`Patgiri, A.; Witten, M. R.; Arora, P. S. “Solid Phase Synthesis of Hydrogen Bond
`Surrogate Derived α-Helices: Resolving the Case of a Difficult Amide Coupling” Org.
`Biomol. Chem. 2010, 8, 1773-1776.
`
`Henchey, L. K.; Kushal, S.; Dubey, R.; Chapman, R. N.; Olenyuk, B. Z.; Arora, P. S.
`"Inhibition of Hypoxia Inducible Factor 1–Transcription Coactivator Interaction by a
`Hydrogen Bond Surrogate α-Helix." J. Am. Chem. Soc. 2010, 132, 941-943.
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`Jochim, A. L.; Miller, S. E.; Angelo, N. G.; Arora, P. S. “Evaluation of triazolamers as
`active site inhibitors of HIV-1 protease.” Bioorg. Med. Chem. Lett. 2009, 19, 6023-6026.
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`Jochim, A. L.; Arora, P. S. “Assessment of helical interfaces in protein-protein
`interactions.” Mol. BioSyst. 2009, 5, 924-926. (Invited Article for the Emerging
`Investigators issue).
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`15.
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`Bu, J.; Dong, X. Y.; Zhang, J. Z. H.; Arora, P. S. “Dynamical Binding of Hydrogen-
`Bond Surrogate Derived Bak Helices to Antiapoptotic Protein Bcl-xL.” J. Phys Chem. B
`2009, 113, 3565–3571.
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`Arora, P.S.; Ansari, A. Z. “A Notch above other inhibitors.” Nature 2009, 462, 171-172.
`(Invited commentary)
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`Guarracino, D. A.; Arora, P. S. “Making Strides in Peptide-Based Therapeutics.” Chem.
`Biol. 2009, 16, 919-920. (Invited commentary)
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`Henchey, L. K.; Jochim, A. L.; Arora, P. S. “Contemporary Strategies for the
`Stabilization of Peptides in the α-Helical Conformation.” Curr. Opin. Chem. Biol. 2008,
`12, 692-697. (Invited Review)
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`Kirshenbaum, K.; Arora, P. S. “Cross-dressing proteins by olefin metathesis” Nature
`Chem. Biol. 2008, 4, 527-528.
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`Chapman, R. N.; Kulp, J. L. III; Patgiri, A.; Kallenbach, N. R.; Bracken, C.; Arora, P. S.
`“Trapping a Folding Intermediate of the Alpha-Helix: Stabilization of the Pi-Helix.”
`Biochemistry (Accelerated Publication) 2008, 47, 4189-4195.
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`14. Wang, D.; Liu, J.; Zheng, Q.; Lu, M.; Arora, P. S. “Atomic Structure of a Short α-Helix
`Stabilized by a Main Chain Hydrogen Bond Surrogate”. J. Am. Chem. Soc. 2008, 130,
`4334-4337.
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`13. Wang, D.; Lu, M.; Arora, P.S. “Inhibition of HIV-1 Fusion by Hydrogen-Bond Surrogate
`Based α-Helices.” Angew. Chem. Int. Ed. 2008, 47, 1879-1882.
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`Patgiri, A.; Jochim, A. L.; Arora, P. S. “Structure and Function in Hydrogen-Bond
`Surrogate Based α-Helices.” Acc. Chem. Res. 2008, 41, 1289-1300. (Invited article for a
`special issue on peptidomimetics).
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`Angelo, N.; Henchey, L. K.; Waxman, A. J.; Wink, D.; Canary, J. C.; Arora, P. S.
`“Synthesis and Characterization of Aldol Condensation Products from Unknown
`Aldehydes and Ketones: An
`Inquiry-Based Experiment
`in
`the Undergraduate
`Laboratory.” J. Chem. Ed. 2007, 84, 1816-1818.
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`Angelo, N.; Arora, P. S. “Solution and Solid Phase Synthesis of Triazole Oligomers that
`Display Protein-like Functionality.” J. Org. Chem. 2007, 72, 7963-7967.
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`Wang, D.; Chen, K.; Dimartino, G.; Arora, P. S. “Nucleation and Stability of Synthetic
`α-Helices.” Org. Biomol. Chem. 2006, 4, 4074-4081.
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`Chapman, R. N.; Arora, P. S. “Optimized Synthesis of Hydrogen-Bond Surrogate
`Helices: Surprising Effects of Microwaves on the Activity of Grubbs Catalysts.” Org.
`Lett. 2006, 8, 5825-5828.
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`Wang, D.; Chen, K.; Kulp, J. L. III; Arora, P. S. “Evaluation of Biologically Relevant
`Short α-Helices Stabilized by a Main-Chain Hydrogen-Bond Surrogate.” J. Am. Chem.
`Soc. 2006, 128, 9248-9256.
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`Angelo, N.; Arora, P. S. “Nonpeptidic Foldamers from Amino Acids: Synthesis and
`Characterization of 1,3-Substituted Triazole Oligomers.” J. Am. Chem. Soc. 2005, 127,
`17134-17135.
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`Wang, D.; Liao, W.; Arora, P. S. “Enhanced Metabolic Stability and Protein-Binding
`Properties of Artificial α-Helices Derived from a Hydrogen-Bond Surrogate: Application
`to Bcl-xL.” Angew. Chem. Int. Ed. 2005, 44, 6525-6529.
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`Dimartino, G.; Chapman, R. N.; Wang, D. Arora, P. S. “Solid-Phase Synthesis of
`Hydrogen-Bond Surrogate-Derived α-Helices.” Org, Lett. 2005, 7, 2389-2392.
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`Arora, P. S. “Adding Specificity to Artificial Transcription Factors.” Chem. Biol. 2005,
`12, 262-263.
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`Arora, P. S.; Kirshenbaum, K. "Nano-Tailoring: Stitching Alterations on Viral Coats."
`Chem. Biol. 2004, 11, 418-420.
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`2.
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`1.
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`Chapman, R. N.; Dimartino, G.; Arora, P.S. “A Highly Stable Short α-Helix Constrained
`by a Main Chain Hydrogen Bond Surrogate. J. Am. Chem. Soc. 2004, 126, 12252-12253.
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`Publications from Postdoctoral, Doctoral and Undergraduate Studies:
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`Jespersen, C.; Soragni, E.; Chou, C. J.; Arora, P. S.; Dervan, P. B.; Gottesfeld, J. M. “Chromatin
`structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4
`genes in pancreatic cancer cells.” Bioorg. Med. Chem. Lett. 2012, 22, 4068-4071.
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`Dickinson, L. A.; Burnett, R.; Melander, C.; Edelson, B. S.; Arora, P. S.; Dervan, P.B.;
`Gottesfeld, J.M. “Arresting Cancer Proliferation by Chemical Regulation of Histone H4 Gene
`Transcription.” Chem. Biol. 2004, 11, 459-473.
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`Eisenfuhr, A.; Arora, P.S.; Sengle, G.; Nowick, J.S.; Famulok, M. “A Ribozyme with 1,4-
`Michaelase Activity: Synthesis of the Substrate Precursors.” Bioorg. Med. Chem. 2003, 11, 235-
`249.
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`Arora, P.S.; Ansari, A.Z.; Best, T.P.; Ptashne, M.; Dervan, P.B. “Design of Artificial
`Transcriptional Activators with Rigid Poly-L-proline Linkers.” J. Am. Chem. Soc. 2002, 124,
`13067-13071.
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`Belitsky, J.M.; Leslie, S.J.; Arora, P.S.; Beerman, T.; Dervan, P.B. “Cellular uptake of
`polyamide-dye conjugates.” Bioorg. Med. Chem. 2002, 10, 3313-3318.
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`Sengle, G.; Eisenfuhr, A.; Arora, P.S.; Nowick, J.S.; Famulok, M. “Novel RNA catalysts for the
`Michael reaction.” Chem. Biol. 2001, 8, 459-473.
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`Sengle, G.; Jenne, A.; Arora, P. S.; Seelig, B.; Nowick, J. S.; Jaschke, A.; Famulok, M.
`“Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA
`5'-ends.”Bioorg. Med. Chem. 2000, 8, 1317-29.
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`Arora, P. S.; Van, Q. N.; Famulok, M.; Shaka, A. J.; Nowick, J. S. “Design and synthesis of a
`transition state analogue for the Diels-Alder reaction.” Bioorg. Med. Chem. 1998, 6, 1421-28.
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`Benson, S.C.; Arora, P.S.; Glazer, A. N. “Heterodimeric DNA-binding dyes designed for energy
`transfer: synthesis and spectroscopic properties.” Nucleic Acids Res. 1993, 21, 5727-35.
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`Patents
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`1. Dervan, P.B.; Dickinson, L. A.; Arora, P.S.; Burnett, R.; Gottesfeld, J. M. “Methods of
`Treating Cancer by Inhibiting Histone Gene Expression.” PCT/US05/14631
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`2. Arora, P. S. and Chapman R. N. “Methods for Preparing Internally Constrained Peptides
`and Peptidomimetics.” U.S. Patent Numbers 7,202,332; 7,705,118; 8,071,541.
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`3. Arora, P. S. and Angelo, N. A. “Methods for Preparing Nonpeptidic Oligomers from
`Amino Acids.” U.S. Patent Number 7,834,038 B2.
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`4. Arora, P. S.; Tosovska, P. T.; Bullock, B. N.; Guarracino, D. A. “Oligooxopiperazines and
`Methods of Making and Using Them.” PCT/20120040992.
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`5. Arora, P.S. and Wang, D. “Control of Viral-Host Membrane Fusion with Hydrogen Bond
`Surrogate-Based Artificial Helices.” PCT/20110046043.
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`6. Arora, P. S.; Olenyuk, B. Z.; Chapman, R. N.; Henchey, L. K.; Block, K. M. “Inhibiting
`Interaction Between the HIF-1α and p300/CBP with Hydrogen-Bond Surrogate Based
`helices.” PCT/20110245175.
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`7. Arora, P.S.; Jochim, A. L. “System and Uses for Generating Databases of Protein
`Secondary Structures Involved in Inter-Chain Protein Interactions.” PCT/20100281003.
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`8. Arora, P. S.; Bar-Sagi, D.; Patgiri, A; Yadav, K. “Hydrogen Bond Surrogate Macrocycles
`As Modulators Of Ras/Sos.” Filed April 20, 2010.
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`Invited Presentations:
`
`1. New York Academy of Sciences, Chemical Biology Discussion Group, February 7, 2005.
`2. CUNY-Hunter College, Department of Chemistry, April 22, 2005.
`3. George Washington University, Department of Chemistry, April 29, 2005.
`4. City College of New York, Department of Chemistry, October 24, 2005
`5. CUNY-Queens College, Department of Chemistry, November 16, 2005.
`6.
`Polytechnic University, Chemical & Biological Sciences, December 8, 2005
`7.
`First Joint Conference of American Chemical Society & Indian Council of Scientific &
`Industrial Research, National Chemical Laboratory, Pune, India, January 6-9, 2006.
`8. Advances in Organic Chemistry and Chemical Biology, ACS-CSIR, Hyderabad, India,
`January 11-12, 2006.
`9.
`Long Island University, Department of Chemistry, February 28, 2006
`10. Georgia Institute of Technology, School of Chemistry and Biochemistry, April 13, 2006.
`11. Mount Sinai School of Medicine, The Sinai Molecular Interactions Discussion Group, June
`6, 2006.
`12. University of Arizona, Department of Chemistry, July 6, 2006.
`13. North Carolina State University, Department of Chemistry, August 28, 2006
`14. University of North Carolina, Department of Chemistry, August 29, 2006
`15. Duke University, Department of Chemistry, August 30, 2006
`16. Trimeris Inc., August 31, 2006
`17. American Chemical Society National Meeting, Inaugural Young Investigators Symposium,
`San Francisco 2006.
`18. University of Michigan, Department of Chemistry, October 31, 2006.
`19. Wayne State University, Department of Chemistry, November 1, 2006.
`20. CUNY NYC College of Technology, February 15, 2007.
`21. Emory University, Department of Chemistry, February 26, 2007.
`22. University of Delaware, Department of Chemistry, March 7, 2007.
`23. University of California at San Diego, Department of Chemistry, March 12, 2007.
`24. University of California at Irvine, Department of Chemistry, March 14, 2007.
`25. California Institute of Technology, Department of Chemistry, April 4, 2007.
`26. University of California at Los Angeles, Department of Chemistry, April 5, 2007.
`27. University of Wisconsin-Madison, Department of Chemistry, April 24, 2007.
`28. University of Illinois at Chicago, Department of Chemistry, April 26, 2007.
`29. Bioorganic Gordon Conference, Proctor Academy, June 10-15, 2007. (Poster Talk)
`30. Rockefeller University, Chemical Biology Seminar, Jan 25, 2008.
`31. Pace University, Department of Chemistry, April 14, 2008.
`32. New York Structural Biology Discussion Group- 4th Winter Meeting, January 22, 2009.
`33. Bristol-Myers Squibb Research and Development, Princeton, NJ, February 23, 2009.
`34. University of California at Davis, Department of Chemistry, March 10, 2009.
`35. Stony Brook University, Department of Chemistry, March 19, 2009.
`36. NYU Draper Society, April 16, 2009
`37. 9th Annual Symposium of the New York University Center for Genomics and Systems
`Biology, May 15, 2009
`38. Medicinal Chemistry Section, American Chemical Society National Meeting, Washington,
`D.C. 2009.
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`Paramjit Arora
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`39. Biotechnology Section, American Chemical Society National Meeting, Washington, D.C.
`2009.
`40. University of Chicago, Department of Chemistry, October 14, 2009.
`41. Pfizer-La Jolla, November 2, 2009.
`42. Wesleyan University, Department of Chemistry, November 6, 2009.
`43. Tulane University, Department of Chemistry, February 18, 2010.
`44. University of New Orleans, Department of Chemistry, February 19, 2010.
`45. Gordon Research Conference, Peptides, February 28-March 5, 2010.
`46. Vanderbilt Institute of Chemical Biology, September 29, 2010.
`47. NIH Protein-Protein Interaction Workshop, October 28-29, 2010.
`48.
`International Chemical Congress of Pacific Basin Societies (PacificChem), December
`2010.
`49. Virginia Polytechnic Institute, Department of Chemistry, January 20, 2011.
`50. Genomics Institute of the Novartis Research Foundation, La Jolla, CA, February 7, 2011.
`51. Colorado State University, Department of Chemistry, March 7, 2011.
`52. Temple University, Department of Chemistry, March 17, 2011.
`53. University of Pennsylvania, Department of Chemistry, March 21, 2011.
`54. Rutgers University, Department of Chemistry, April 1, 2011.
`55. Boston College, Department of Chemistry, April 4, 2011.
`56. University of Nebraska Medical Center, Eppley Institute, Annual Short Course in Cancer
`Biology, May 23-24.
`57. Tufts University, Department of Chemistry, October 18, 2011.
`58. University of Tennessee, Department of Chemistry, November 3, 2011.
`59. Bordeaux 2012 Symposium On Foldamers, Bordeaux, France, January 30-February 2,
`2012. (Keynote speaker)
`60. Texas A&M University, Department of Chemistry, February 9, 2012
`61. University of Missouri, Kansas City, School of Pharmacy, April 2, 2012.
`62. The Ohio State University, Department of Chemistry, April 12, 2012.
`63. University of Rochester, Department of Chemistry, May 18, 2012.
`64. University of Washington-Seattle, Department of Chemistry, June 6, 2012.
`65. University of Toronto, Department of Chemistry, July 3, 2012.
`66. American Chemical Society National Meeting, Philadelphia, 2012, “Studying the Role of
`the Protein Backbone through Isosteric Substitution” Symposium, August 19, 2012.
`67. Purdue University, Department of Chemistry, August 30, 2012.
`68.
`Imperial College London, UK, Department of Chemistry, September 11, 2012.
`69. PPI-Net Young Researcher Symposium, Leeds UK, September 13, 2012. (Plenary speaker)
`70. Lehigh University, Department of Chemistry, November 28, 2012.
`71. Janssen Research & Development, Spring House, December 3, 2012.
`72.
`International Symposium on Challenges in Chemical Biology, IICB-Kolkata, India,
`January 29-29, 2013.
`73. University of Texas at Dallas, Department of Chemistry, March 21, 2013.
`74. Memorial Sloan Kettering Cancer Center, Molecular Pharmacology and Chemistry
`Research Seminar Series, April 2, 2013.
`75. Experimental Biology 2013, Boston MA: American Society for Pharmacology and
`Experimental Therapeutics, Session “Transcription factors as therapeutic drug targets”,
`April 23, 2013.
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`Paramjit Arora
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`76. Moffitt Cancer Center, Tampa, FL, Grand Rounds Seminar Series, May 22, 2013.
`77. 18th Albany Conversations, Albany NY, June 11-15, 2013.
`78. GDCh Science Forum, "Molecules of Life - Molecules in Life", Darmstadt, Germany,
`September 1-4, 2013.
`79. University of Minnesota, Department of Medicinal Chemistry, September 24, 2013.
`80. Eli Lilly & Co., Organic & Medicinal Chemistry Seminar Series, October 7, 2013.
`81. 4th Modern Solid Phase Peptide Synthesis & Its Applications Symposium, Kobe, Japan,
`November 2-4, 2013.
`82. University of Montreal, Department of Chemistry, November 27, 2013.
`
`
`Funding
`
`Current funding
`
`
`
`
`R01GM073943
`
`National Institutes of Health
`Period: 02/01/05 - 08/31/14
`Project title: Biomolecular Recognition with Artificial α-Helices.
`Role: Principal Investigator
`
`National Science Foundation
`Period: 03/01/12 – 02/28/15
`Project title: A Systematic Approach to Targeting Protein Interfaces with Nonpeptidic Helix
`Mimetics
`Role: Principal Investigator
`
`
`Pending funding
`
`
`
`
`CHE-1151554
`
`National Institutes of Health
`Period: 07/01/13 - 06/31/18
`Project title: p53 Reactivation therapeutics for HPV-positive head and neck cancer
`Role: Principal Investigator
`
`R01CA178855
`
`
`
`
`
`National Institutes of Health
`Period: 07/01/13 - 06/31/18
`Project title: Small Molecule Modulators of HIF-1α Signaling
`Role: Principal Investigator
`
`R01GM108023
`
`
`
`
`Prior funding
`
`
`National Science Foundation
`Period: 04/01/09 – 03/31/13
`Project title: Nonpeptidic α-helix and β-strand mimetics
`Role: Principal Investigator
`
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`CHE0958457
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`CHE-0848234
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`R21HL094969
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`R01GM078266
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`National Science Foundation
`Period: 02/01/10 – 01/31/13
`Project title: MRI-R2: Acquisition of a MALDI-TOF Mass Spectrometer
`Role: Principal Investigator
`
`National Science Foundation
`Period: 8/1/09-7/31/13
`Project title: Stereodynamic Coordination Complexes
`Role: Co-Principal Investigator (James Canary)
`
`
`National Institutes of Health
`Principal Investigator: Dafna Bar-Sagi
`Period: 9/30/09 – 2/29/12
`Project title: Positive and Negative Regulation of TRK-Ras Signaling
`Role: Co-Principal Investigator
`
`
`National Institute of Health
`Principal Investigator: Paramjit S. Arora
`
`
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`Period: 12/01/08 - 11/30/11
`
`Project title: Inhibition of Protein-Protein Contacts in VEGF Transcription by Synthetic
`Helices.
`
`Research Corporation-Cottrell Scholar Award (CS1224)
`Principal Investigator: Paramjit S. Arora
`Period: 07/01/05 - 06/30/08
`Project Title: Control of Protein-Protein Interactions with Artificial Alpha Helices and
`Innovations in the Teaching and Implementation of Organic Chemistry.
`
`Whitehead Fellowship for Young Investigators in Biomedicine
`Principal Investigator: Paramjit S. Arora
`Period: 09/01/05 - 08/31/06
`Project Title: Sequence-specific recognition of DNA by artificial alpha-helices.
`
`New York State Office of Science, Technology & Academic Research–JD Watson Award
`Principal Investigator: Paramjit S. Arora
`Period: 01/01/03 - 12/31/04
`
`Project Title: Development of Sequence-Specific RNA Binding Ligands.
`
`American Chemical Society-Petroleum Research Fund
`Principal Investigator: Paramjit S. Arora
`Period: 07/01/04 - 06/30/06
`Project Title: A General Approach for the Stabilization of Short Peptides in the Desired
`Secondary Structures.
`
`National Science Foundation
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`Paramjit Arora
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`Paramjit Arora
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`Principal Investigator: Nicholas Geacintov
`Period: 05/01/03 - 4/30/06
`Project title: Acquisition of an Ion-Trap Mass Spectrometer
`
`Schwartz Family Research Fund
`Principal Investigator: Leo Gordon
`Period: 06/05/08 – 06/04/10
`Project title: Structure-based Design of Small-molecule Ligands for Bcl6 BTB Domain
`Role: Co-PI
`
`Research Group Members
`
`Current postdoctoral fellow
`Monika Raj
`
`
`Ph.D., Indian Institute of Technology Kanpur
`Paul Thomson
`Ph.D., CUNY City College; recipient of an NIH Postdoctoral
`Fellowship
`
`
`Former postdoctoral fellows
`Gianluca Dimartino
`Ph.D., Birmingham University, U.K. (currently Research Scientist
`at Krafts, Inc.)
`Ph.D., Yale University (currently Assistant Professor at College of
`New Jersey)
`Ph.D., Macquarie University, Australia (currently Research
`Scientist at Nanometics)
`Ph.D., Iwate University, Aomori, Japan
`
`Danielle Guarracino
`
`Andrew Mahon
`
`Hiroko Matsuda
`
`Current graduate students
`Steve Miller
`
`
`Brooke Bullock
`
`Steven Joy
`
`
`Cheng Wang
`
`
`Andrew Watkins
`
`Michael Wuo
`
`Huabin Wu
`
`
`Ashley Modell
`
`
`Former graduate students
`Petra Tosovska
`
`Anupam Patgiri
`Monica Menzenski
`Melissa Cambria
`Laura K. Henchey
`Andrea L. Jochim
`
`Ross Chapman
`
`
`
`Ph.D. Expected 2013
`Ph.D. Expected 2013
`Ph.D. Expected 2014
`Ph.D. Expected 2015
`Ph.D. Expected 2016
`Ph.D. Expected 2016
`Ph.D. Expected 2016
`Ph.D. Expected 2017
`
`Ph.D. 2013 (currently Clinical Teaching Faculty at NYU)
`Ph.D. 2011 (currently postdoctoral fellow at Rockefeller Univ.)
`M.S. 2011 (currently Research Scientist at Regeneron)
`M.S. 2011
`Ph.D. 2010 (currently faculty at University of Tampa, Fl)
`Ph.D. 2010 (currently student at Stony Brook University Medical
`School)
`Ph.D. 2007 (currently Research Scientist at Reckitt Benckiser,
`Inc.)
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`Rebecca Freilich
`Thomas Brewer
`Mike Witten
`
`Rebecca Wissner
`
`Irina Bergenfeld
`Wei Liao
`
`Adam Waxman
`
`
`Anjali Sheth
`Tracey Spencer
`Tania Lupoli
`
`Deyun Wang
`Nicholas G. Angelo
`Yuting Huang
`
`Current undergraduate students:
`Natasha Mitchko
`
`B.S. Expected 2015
`Marc Vittoria
`
`B.S. Expected 2014
`
`Former undergraduate students:
`Rachel Ness
`B.S. 2013 (recipient of the Goldwater Fellowship; pursuing Ph.D.
`in pharmacology at St. Judes Children’s Hospital)
`B.S. 2012 (pursuing Ph.D. in chemical biology at UCSF)
`B.S. 2012 (pursuing Ph.D. in chemistry at UC Berkeley)
`B.S. 2009 (recipient of the 2008 Beckman Scholar award; pursuing
`Ph.D. in chemistry at Harvard University)
`B.S. 2009 (pursuing Ph.D.
`in chemistry at University of
`Pennsylvania)
`B.S. 2008 (recipient of the 2007 Beckman Scholar award)
`B.S.2007 (pursuing an Engineering degree at NYU–Stevens
`College)
`B.S. 2007 (recipient of the 2007 Beckman Scholar award; pursuing
`M.D. at Duke University)
`B.S. 2006 (pursuing M.D. at UMDNJ)
`B.S. 2006 (pursuing an internship at Merck Pharmaceuticals)
`B.S. 2005 (recipient of the 2008 Beckman Scholar award; Ph.D.
`Harvard University; currently postdoc at Cornell Medical School)
`B.S. 2004 (pursuing Ph.D. in chemistry at University of Michigan)
`B.S. 2004 (pursuing M.D.-Ph.D. at NYU)
`
`Allison Lucier
`
`
`
`Paramjit Arora
`
`M.S. 2006 (currently student at University of Chicago Law
`School)
`Ph.D. 2007 (currently Research Scientist at Merck)
`Ph.D. 2007 (currently Clinical Teaching Faculty at NYU)
`M.S. 2008 (currently Research Scientist at Cubist Pharmaceuticals)
`
`
`
`Ryan Casey
`Sruthi Reddy
`
`
`Memberships and Affiliations
`American Chemical Society
`New York Academy of Science, Chemical Biology Discussion Group, Steering Committee
`Member (2004-present)
`New York Section, American Chemical Society, Organic Topical Group Chair (2008-present)
`Aileron Therapeutics, Scientific Advisor (2008-present)
`Protagonist Therapeutics, Scientific Advisor (2012)
`Full Member NYU Cancer Center
`
`Departmental and Professional Service
`Steering Committee Member, New York Academy of Science Chemical Biology Discussion
`Group.
`Chair, Organic Topical Group of the New York ACS (2008-present)
`Member of NIH study section Synthetic and Biological Chemistry B (2011-2017)
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`Paramjit Arora
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`Ad hoc member of NIH study section Synthetic and Biological Chemistry A and Synthetic and
`Biological Chemistry B (2006, 2008, 2010)
`Grant proposal reviewer for NSF Chemistry Division (2003-present)
`Ad hoc member NSF Panel Chemistry of Life Processes (2009, 2012, 2013)
`Reviewer for JACS, JOC, Org. Lett., Biochemistry, J. Med. Chem., ACS Chem. Biol., Nature,
`Nature Chem. Biol., Nature Chemistry, Angewandte Chemie, ChemBiochem, Org.
`Biomolec. Chem., Tetrahedron, Tetrahedron Lett, Bioorg. Med. Chem. and Bioorg. Med.
`Chem. Lett.
`Graduate Admissions Committee (2003-2009)
`Director of Graduate Recruitment (2003-2009)
`NYU GSAS Honors and Awards Committee (2008-present)
`NYU GSAS Teaching Awards Committee (2008-present)
`NYU Provost Faculty Fellowship Committee (2008-2012)
`Dean of Science Committee on Undergraduate Research Opportunity Program (2004)
`Departmental Colloquium Committee (2002-2009)
`Chemistry Department Faculty Search Committee Member (Molecular Design Institute Searches
`2006 & 2007; Chemical Biology Search 2008 & 2010; Biophysics Search 2008)
`Chair, Chemistry Department Sokol Search Committee 2009 (Prof. Keith Woerpel)
`Chair, Departmental Tenure Committee (Prof. Lara Mahal)
`Dean’s Undergraduate Research Funds Committee (2004-present)
`
`Courses Taught
`
`Chem-UA 227/V25.0325 Honors Organic Chemistry I Fall semesters 2006, 2009, 2011
`V25.0352 Honors Organic Chemistry Lab Spring semesters 2003–2008 (new course)
`G25.2884 Bioorganic Chemistry Spring semesters 2003–2009, 2011, 2013 (new course)
`G25.1313 Structure and Theory in Organic Chemistry Fall semesters 2004, 2005, 2007
`V25.0245 Organic Lab I Fall semester 2007
`Chem-UA 226/228 Organic Chemistry II Lab, Spring 2012
`V25.0245 & V25.0246 Organic Lab I & II Reorganization 2009-2010
`CHEM-UA 881 Biochemistry I, Fall 2012
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`Page 13 of 13
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