.g-v-W-'°*===’=*‘='-"'
`
`Case IPR2014—00642
`
`Patent 6,258,044
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`
`U.S. ENDOSCOPY GROUP, INC. (PETITIONER)
`
`Petitioner
`
`V.
`
`CDX DIAGNOSTICS INC. and
`
`SHARED MEDICAL RESOURCES LLC
`
`Patent Owners
`
`I
`'3
`2'3 g
`E
`
`
`
`CASE IPR20 14-00642
`
`Patent 6,258,044
`
`CDX DIAGNOSTICS INC.
`
`Patent Owner
`
`CASE IPR20I4-00639
`
`Patent 6,676,609
`
`CASE IPR2014-00641
`
`Patent 7,004,913
`
`CDX DIAGNOSTICS INC.’S AND SHARED MEDICAL RESOURCES LLC’S
`NOTICE OF CROSS-EXMINATION DEPOSITION OF PETITIONER’S EXPERT
`DR. MICHEL KAHALEI-I
`
`UNDER 37 C.F.R. §42.53
`
`1
`
`

`
` Case If-‘R2014-0064?.
`
`
`
`
`Mail Stop “PATENT BOARD”
`Patent Trial and Appeal Board
`U.S. Patent and Trademark Office
`
`Patent 6,258,044
`
`P.O. Box 1450
`Alexandria, VA 223 13- 1 45 0
`
`

`
`
`
`Case 113112014-00642
`Patent 6,258,044
`
`The parties have agreed that the Patent Owners CDX Diagnostics Inc. and
`
`Shared Medical Resources, LLC will conduct its cross-examination by deposition
`
`of the Petitioner’s expert as follows:
`
`Place:
`
`Levisohn Berger LLP
`11 Broadway, Suite 615
`New York, New York 10004
`
`Time:
`
`Monday, December 8, 2014.
`
`Declarant Name:
`
`DR. MICHEL KAHALEH
`
`In accordance with 37 C.F.R. §42.53(d)(1), the parties have conferred, and
`
`Petitioner U. S. Endoscopy Group, LLC (“Petitioner”) has represented that Dr.
`
`Kahaleh is willing to appear at the time and location indicated above. The cross-
`
`examination will be taken before a Notary Public or other officer authorized by law
`
`to administer oaths. The deposition may be recorded by audio, audio visual, and/or
`
`stenographic means. The arrangements for recording the deposition will be made
`
`by counsel for Patent Owner(s).
`
`Dated: November 20, 2014
`
`Respectfully Submitted,
`« LEVISOHN BERGER LLP
`
`Isl Peter L. Berger
`Peter L. Berger (Reg. No. 24,5 70)
`11 Broadway, Suite 615
`New York, New York 10004
`212-486~7272 (Telephone)
`212-486-0323 (Facsimile)
`Attorney for Patent Owners
`
`
`
`

`
`
`
`Case IPR20I4—00642
`
`Patent 6,258,044
`
`CDX Diagnostics, Inc. and Shared
`Medical Resources, LLC
`
`

`
`
`
`Case [PR20l4-00642
`
`Patent 6,258,044
`
`CERTIFICATE OF SERVICE
`
`The undersigned certifies that a copy of the foregoing CDX DIAGNOSTICS
`INC.’S AND SHARED NEEDICAL RESOURCES LLC’S NOTICE OF
`
`CROSS-EXMINATION DEPOSITION OF PETITIONER’S EXPERT DR.
`MICHEL KAHALEH was served electronically via email on November 20,
`
`2014 to the following:
`
`Todd R. Tucker (ttucker@calfee.com)
`CALFEE, HALTER, & GRISWOLD LLP
`The Calfee Building
`1405 East Sixth Street
`
`Cleveland, OH 441 14
`
`Respectfully Submitted,
`
`/s/ Peter L. Berger
`Peter L. Berger (Reg. No. 24,570)
`Attorney for Patent Owners
`CDX Diagnosticsilnc. and
`Shared Medical Resources, LLC
`
`

`
`

`
`Editor: John H. Ditckx, MD.
`Senior Acquisitions Edz'tor.' Elizabeth Randolph
`Project Mcmager: Marjory Spraycar
`Managing Editor: Vincent Ercolano
`Art Director: Jonathan Dimes
`Copy Editor." Harriet Felscher
`-
`Des'ign.' Dan Pfistercr
`Prodzrction Coordinator." Marettc Magargle-Smith
`Pririting Coordinator.‘ Brian Smith
`On-Line Editors." Barbara Fcrretti. Ruth Kendall
`Pr0ofi'erzders: Audrey Knox, lolanta Obrebska, Margaret Swanson,
`Nataiie Tyler, Barbara Werner
`'
`
`Illus!rcm'or1.s'.' Neil O; Hardy
`Additional mrworfc by Michael Schenk, Mary Anna Barratt—Dimes,
`Caitlin Ducicwall. and Rob Dackwall.
`
`Graphic assistance by InATandem Design and Hope Jester.
`
`Copyright 1997
`Williams & Wilkins
`351 W. Camden Street
`Baltimore, MD 212.01—2436 USA
`
`Copyright by Williams & Wilidns: 1987, 1st ed.‘
`
`All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form or by
`any means, including photocopying, or utilized by any inforrnation storage and retrieval system without written per-
`mission from the copyright owner.
`'
`
`Szer1‘morz’.r is a_ registered trademark of Williams & Willtins.
`
`Database design by Lexi—Comp, Inc., Hudson, OH
`Printed in the Uni ted States of America by Rand McNally, Versailles, KY
`
`First Edition 1987
`
`Library of Congress. Cataloging-in-Publication Data
`
`ISBN 400193
`
`Stedrnan‘s concise medical dictionary : illustrated. — 3rd ed. /
`editor, John H. Dirckx.
`p.
`cm.
`ISBN 0-683-40019-3
`.
`I. Dirclot, John H., 1933-
`1. Medicim-.—Dictionaries.
`II. Stedman, Thornas Lathrop, I853»-1938.
`I11. Title: Concise medical
`dictionary
`,
`1. Dictionaries, Medical.
`{DNLM]:
`W 13 88125 1997]
`R121.S8
`1997
`610’.3—dc20
`DNLMIDLC
`
`for Library of Congress
`
`

`
`bioassay
`
`100
`
`hlopsfl.
`
`nioP5Y/T
`
`'9
`
`cavity in health and disease (e.g., dental c
`am”.
`mastication, periodontal disease).
`radiation b., science that studies the biologic
`3!
`effects of ionizing radiation.
`bioocnjass (bi’o—mas). The total weight of 311 ii‘.
`‘mg things in a given area, biotic communj ‘
`species population, or habitat; a measure uf [BEE
`biotic productivity.
`binome (bi’6m). The total complex of biotic com
`munities occupying and characterizing a paniw
`lar geographic area or zone. {bio- + —ome]
`bi-0-me-channics (bi-6-rnc—kan’iks). The scienc,
`concerned with the action of forces,
`internal UH
`external, on the living body.
`._
`hi-0-medal’-cal (bi—6—rned’ivkfl).
`1. Pertainingto
`aspects of the biologic sciences that relate to D,
`underlie medicine. 2. Biological and medical, .13
`encompassing both the science(s) and the moi
`medicine.
`
`
`
`'
`
`ganisms, as contrasted with analysis of its chemi—
`cal or physical properties.
`biuooaavailaaobileioty (bi’o—a-val’a—bil’i—te). The
`physiological availability of a given amount of a
`drug, as distinct from its chemical potency; pro—
`portion of the administered dose which is ab
`Sflfbed 51130 T115 l310GdStF6aI1‘1-
`bi-0-chem-iucal {bi—o-kem’i—kal). Relating to bio»
`chemistry.
`bi-oochern-isutry {bi-o—keni’is-tre). The chemis-
`try of living organisms and of the chemical, mo-
`lecular, and physical changes occurring therein.
`biao-cidual (bi~c‘>—si’dfl). Destructive of life; par-
`ticularly pertaining to microorganisms. [bio~ + L.
`caeda, to kill]
`bi-so-cy-her-net-sics (bi’6-si-ber—net'i.lcs), The sci—
`ence of communication and control within a liv~
`ing organism, particularly on a molecular basis.
`bi-0-deograd-anbie (bi’o—dE—gra'd’a~bl). Denoting
`a substance that can be chemically degraded or
`decomposed by natural effectors (e.g., weather,
`soil bacteria, plants, annuals).
`bi.o.de.g1-a..da.tim-j_ gm biotransfomiation.
`biwo-feed-back (bi-oufed'bal(). A training tech-
`nique that enables an individual
`to gain some
`element of voluntary control over autonomic
`body functions; based on the learning principle
`that a desired response is learned when received
`information such as a recorded increase in slcin
`temperature (feedback) indicates that a specific
`thought complex or action has produced the de-
`sired physiological response.
`EMG b., a form of b. that uses an electromy—
`ographic measure of muscle tension as the physi-
`cai symptom to be deconditioned, such as tension
`in the frontalis muscle in the head which can
`cause headaches.
`
`-
`
`
`
`
`A}
`
`guaedle blup5l' —-
`
`
`
`excision biopsy
`
`hiapsy
`.___________j
`
`binoomernobrane (bi-o~mem’bran). A sttncrm
`bounding a cell or cell organelle; it contains up
`ids, proteins, glycolipids, steroids, etc. SYN mam
`brana [NA], membrane (2).
`bi-owmeatriocian (bi~o-me-trish’an).
`specializes in the science of biometry.
`bieom-eotry (bi-om’e-tre). The application of sin.
`tistical methods to the study of numerical data
`based on biological observations and phenomena
`[bio- + G. matron, measure]
`bioo-mi-cro-scope (bi-6-n-fi’lcro~slc6p).
`lump.
`1. Mg.
`biuo-mi-crosacoopy (bi’o—mi'-lo-os’k6~pé).
`croscopic examination of living tissue in th:
`body. 2. Examination of the cornea, aqueous hu-
`mor, lens, vitreous humor, and retina by use of i
`slitlanap combined with a binocular microscope.
`bi-0-no-croasis (bi-6-ne—kro’sis). syn necrobiosis.
`bi-on-it: (bImon’ik). Relating to or developed from
`bionics.
`
`One who
`
`syn slit-
`
`1. The principle
`hi-uo-gen-e-sis (bi-6-jen’e-sis).
`that life oiiginates from preexisting life only and
`never from nonliving mateiial. SEE recapitulation
`theory. 2.. sm biosynthesis.
`[bio- + G. genesis,
`1. The science of biologic
`bi»-onoics (bi—on'ilcs).
`01.1”-_n]
`functions and mechanisms as applied to elec-
`D
`V
`.
`-
`.
`bi-o-geunetaic {bro-je—net’ilc). Relatincr to 1330-
`tronic technology. 2. The science of applying the
`gengsm
`I
`”
`icnowledge gained by studying the characteristics
`of living organisms to the formuiation of noncr-
`biao-inostruament (bi'o-in’st1fi-ment). A sensor
`ganic devices and techniques. [bio~ + electronics]
`or device attached to or embedded in the body to
`record and transmit physiologic data to a receiv-
`biao-pharamaeceu-tics (bI’o-far—ma-sfi’tilcs). The
`ing station.
`study of the physical and chemical properties ofa
`drug, and its dosage form, as related to the onset _
`bi-o-ki-net-ics (bi’6—ki~net’ilcs). The study of the
`duration, and intensity of drug action.
`growth changes and movements that developing
`organisms undergo. [bio- + G. kz'ne'.s-is, motion]
`biuo-phys-ics (bi—6—phyz’iks).
`1. The study of
`biological processes and materials by means of
`bi-oolog-ic, hi-o-log-i-cal (b"i'o—loj'ik, -Ioj’i—l<al).
`Relating to biology.
`'
`the theories and tools of physics. 2. The study Di
`physical processes (e.g., electricity,
`IumiJ1€5'
`his-01-0-gist (bi—ol’o—jist). A specialist or expert in
`biology.
`cence) occun-ing in organisms.
`bi-=01-oogy (bi~ol’o-je).
`T113 Science concerned Elbioop-sy (bi’op—sE). 1. Process of removing has"?
`with the phenomena of life and living organisms.
`from living patients for diagnostic exaJr3.inatlOl|~
`[bio- + G. logos, study]
`2.. A specimen obtained by b. {bio« + G. aptit-
`vision]
`cellular 13., SYN cytoiogy.
`aspiration b., SYN needle I).
`molecular b., study of phenomena in terms of
`molecular interactions; it differs from biochemisv
`brush b., b. obtained by passing a bristled cath-
`try in that it emphasizes chemical
`interactions
`eter into a tubular or hollow organ to remoltt
`cells from suspected areas of disease.
`involved in the replication of DNA, its ‘‘transcrip—
`tion" into RNA, and its “translation” into or exa
`chorionic villus b.,
`transcervical or tranS'
`pression in protein.
`abdominal sampling of the choiionic villi for 25'
`
`
`netic analysis.
`oral b., that aspect of b. devoted to the study of
`
`biological phenomena associated with the oral
`
`endoscopic 13., b. obtained by instrumefl“
`
`
`
`
`
`
`
`
`
`
`
`
`

`
` 51.035!
`
`
`
`s
`
`surface biopsy
`
`
`
`7
`
`mi—
`Fhe
`If «'1
`I‘0-
`_
`l0-
`
`is‘
`*0‘
`
`*1“
`
`_
`3“
`
`*3
`31‘
`I’
`
`i\;a..au..nnn;
`
`_
`
`
`
`
`
`cavity in health and disease (e.g., denta} cafi
`mastication, periodontal disease).
`radiation b., science that studies the bio]
`-
`effects of ionizing radiation.
`ogmii
`biooomass (bi’6-mas). The total weight of an liv
`ing things in a given area, biotic community.
`species population, or habitat; a measure Qfmtaf
`biotic productivity.
`bioome (bi’6m). The total complex of biotic Cu
`munities occupying and characterizing a para .
`lat geographic area or zone. fbio- + —01tne]
`'
`bln0nIneaCh3IlliC5 (bi-o—me~lcan:i1<s). The science
`. concerned with the action of forces,
`intemalm
`. _=.
`external, on the livi.ng body.
`_
`bi-o-med-iocal (bi-c‘>—zned’i-kalj. 1. Pertainjng-in '_j
`aspects of the biologic sciences that relate to
`underlie medicine. 2. Biological and medical, 11,
`encompassing both the science(s} and the am}:
`medicine.
`bi.o.mem-abrane (bio-mem’bran). A strucnm
`bounding a cell or cell organelle; it contains up
`ids, proteins, glycolipids, steroids, etc, sm mm '
`brana [NA], membrane (2).
`-
`bi-0-me-triacian (bi—6-me—trish’z‘in)., One win’
`' specializes in the science of biometry.
`bi-omoe-try (bi-om’é—trE). The application of stal
`tistical methods to the study of numerical dag
`based on biological observations and phenomena _
`[bio— + G. merron, measure]
`bieo-mi-crooscope (bi-c‘:-mi"l<ro-slcop).
`lamp.
`1. Mi.
`biaou-mi-cros-co-py (b?’6-mi-I<ros’ko-pe).
`croscopic examination of living tissue in [hi
`body. 2. Examination of the cornea, aqueous hu-
`mor, lens, vitreous humor, and retina by use ta"
`slitlanip combined with a binocular microscope.
`bi-0-neacro-sis {bi—6-ne~lcrd’sis). SYN oecrobiosis.
`bi-on-ic (bi-on’ilc). Relating to or developed from
`bionics.
`
`
`
`55
`
`sm 35;.
`
`
`
`
`
` Hnfsign bigpsy incision biopsy
`
`'
`
`1. The science of biologic
`bi-onoics (bivon'ilcs).
`functions and mechanisms as applied to elec-
`tronic technology. 2. Thescience of applying the
`lmowiedge gained by studying the characteristics
`of iiving organisms to the formulation of noncr-
`ganic devices and techniques. [bio— + electronics]
`biaoapharama-ceu-tics (bi’6—far-ma-sfi’til:s). The
`study of the physical and chemical properties oia
`drug, and its dosage form, as related to the onsel.
`duration. and intensity of drug action.
`bioo-phys-ics (bf-6-phyz’i.ks).
`1. The study a!
`biological processes and materials by means of
`the theories and tools of physics. 2. The study of
`physical processes (e.g., electricity,
`lumines-
`cence) occurting in organisms,
`fihinop-sy Cbi’op-se). 1. Process of removing tissu_c-
`from living patients for diagnostic examination
`2. A specimen obtained by b. [bio- + G. aptit-
`vision]
`aspiration b., sum needie b.
`brush 1)., b. obtained by passing a bristled cath-
`eter into a tubular or hollow organ to remit
`cells from suspected areas of disease.
`Lt&I15'
`chorionic villus b.,
`transcervical or
`abdominal sampling of the chorionic villi for gr
`netic analysis.
`endoscopic b., 1:. obtained by instrumw”
`
`
`
`

`
`
`
`passed through an endoscope or obtained by a
`needle introduced under endoscopic guidance.
`excision b., excision of tissue for gross and
`microscopic examination in such a manner that
`the entire lesion is removed.
`fine needle 1)., removal of tissue or suspensions
`of cells through a small needle.
`incision b., removal of only a part of a lesion
`by incising into it.
`needle b., any method in which the specimen
`for b.
`is removed by aspirating it through an
`appropriate needle or trocar that pierces the skin,
`or the external surface of an organ. SYN aspiration
`b.
`
`birefrmgenft birefringent
`
`I
`rrique of monitoring vital processes and tran,<;1-nit bi_[.e,fn-“agent
`ting data without wires to a point remote from up
`twice; sphm-nu a I
`subject.
`; birth fienh)‘
`P
`uterus tothe outsi
`‘
`bi-otoic (bi—ot’ik). Pertaining to life.
`2. Specifically, cc
`cis-Hexahydro-2-oxo-1H"
`biuootin (bi'<‘)—tin}.
`of a fetus from its
`thienoi 3,4—rt]irnidazoline—4~vale1ic acid;
`thg D:
`premature b., t
`isorner component of the vitamin B2 compk;
`been achieved wit
`occurring in or required by most organisms am!
`.
`or birth weight 0]
`inactivated by avidin; participates in biologic,‘
`weeks.
`carboxylations.
`,»
`biootni-nides (bi—ot’i-nidz). Compounds of biotin? birth-mark (hm-th
`1
`sion, usually on 1
`e.g., biocytin.
`I
`biamtope (bi’6—t6p). The smallest geography“:
`birth; commonly ,
`area providing un.i.fo:rm conditions for life;
`spas nevus (1),
`physical part of an ecosystem.
`[#3. bios,
`Iifg_;,_’5bis—. 1. Prefix sign
`tapas, place]
`rm’ used to denotg
`'11,;
`bi-ontox-i-coloongy (bi’Eu—tokwsi-l<ol’6-je).
`but separated can;
`study of poisons produced by living orgm-ijgmgf
`Cf. bi—, di-. [1._}
`biuoetoxain (bi—6-tok’sin}. Any toxic substami 2,5-bis(5-I-buntyl
`formed in an animal body, and dCl’I10llStIElbleg_-E
`phene (BBOTJ.
`its tissues or body fluids, or both.
`tivity measurement
`bi-o-transafor-maetion (bI’o-trans—for-ma’shfin!.
`his ill die (bis in di
`The conversion of molecules from one form?‘
`bi'5eX'11°31 (bT~Sek:
`another within an organism,_ often associated wit;
`- P031 55_x35- SEE AL.‘
`change in pharinacologic activity;
`refers esp;-i
`HIS ffilllldividual vs
`cially to drugs and other xenobiotics. SYN biuti
`[Jill am‘-‘_ homosexuz
`gradation
`his-fer-1-nus (bi3-f.
`hing-type (bi’o-tip). 1. A population or group;
`‘ff Eh‘? P‘-1135:
`bi.
`individuals composed of the same genotype, jl
`bl-9'11'1_'3C (_b_ts-1l’E~£
`EACTERJOLOGY former name for biovar. [bio- + -i
`Spofldmg mac PM
`[[
`bones or iiiac fossa
`typos, model}
`,
`_
`bino-var Cbfowvar). A group of bacterial stair‘ bmmuth (Bl) _('3i2
`distinguishable from other strains of the Element; atfjm-"3 '1
`species on the basis of physiological character:
`Seyeml of its 33]“
`[bio'» + variant]
`b‘."""""’» W-wise Ma.
`bicoovudar (b§’ov—yfi~lar). SYN diovular.
`_
`]:'.mu.'th°'515 (bis-
`BiPAlP (hilevel positive airway Dressuj 'b1l:'SIll‘:lljlI1zii11%fi1[(biz!Hu~
`behaves C
`.
`bilevel positive airway pressure.
`helm 1 v
`.
`_
`. .
`.
`bi-pa-sren-tal {b1—pa-ren tal). Having two pare
`meta}; 1-is Salts 3‘: lg
`3
`male and female.
`b'5'_3011~ry (bis’tfi—r
`knife, with a stmjg1-_
`bipoa-rous (bip’§-rds). Bearing two young. [bit
`L. pario, to give birth}
`I
`blunt poing (PfObe_
`Shmng cavities or 11
`bi-par-atite (bi-par’tit). Consisting of two parts
`divisions.
`l
`bit‘ IL dlalect bilflori,
`bi-pen-nate, bi-penani-form '
`lg
`"
`iaslll-f_aE€
`(bl-sL‘il’fE
`§YN acid su]_fa[3_
`form).
`Pertaining to a muscle with a cell
`
`lJhSl.l]-fide ('bi_SfiIIfI.(
`tendon toward which the fibers converge
`
`.bi‘3": an acid sulfide
`either side like the barbs of a feather. [bi-l
`
`'
`i'S"1'£]t6 (bi-s1‘il’fitj
`pemm, feather]
`I
`'.
`bite (bit).
`1_ To inc.
`
`bioPhewI10ItyopiC (bi’fE-n6—tip'i_lc).
`Pertail1|fi'='_‘
`Etlzeact Bf incision
`or characterized by biphenotypy.
`_
`.
`
`'53] 01° food helc‘
`
`hielpheeno-tyopy (bi-tE’n6—tI’pE). The ex?’““
`.”5°d to denote thg a
`
`of markers of more than one cell typfl bl’
`In closing the jaw:
`
`same cell, as in certain leukemias.
`'
` E;.=
`terms such as inter;
`bi-phen-yl (bi-fen’i.l). sYN'dipiieny§.
`d b
`-
`.
`.
`.
`b1-po-lar (bi—pc"i'ler). 1. HflVLflg two poles;
`.
`dasglltlm registration,
`or extremes. 2. Pertaining to a moodllimi.
`made lie" 6'. A won
`
`involving alternating mania and depresslfiflv C
`bitmplaf a“1I_nal or i-
`bi-poften-tiehalei»-ty‘ (bi’p6—ten-she~a11-R? '
`|'l10Vflblee’ablt_e'Dl3]
`
`
`
`pabihty of differentiating along two d6V_¢‘« 01;!
`acrylic
`E_’PlJance
`
`tal pathways. An example is the capaclz
`teeth‘
`fislgned to
`ovary Orb an
`gonad to develop intp either
`bites (bus) P
`
`bi-raamous (bi-ra’rnus). Having two I
`laceration) caerietfai
`
`doubh
`[bi— + L. ramus, branch] _
`‘
`mechanical mils‘-”" J
`
`'
`SCO
`_;
`bi-are-frin-gence (bl~I‘E—frmjens).
`Such as snakelgfiy 2
`
`frrrcriori.
`
`'
`
`
`
`—
`
`si'N
`
`open b., b. requiring a surgical incision.
`punch b., any method that removes a small
`cylindrical specimen for b. by means of a special
`instrument mat pierces the organ directly or
`through the skin or a small incision in the skin.
`shave b., a b. technique performed with a surgi-
`cal blade or a razor blade; used for lesions that
`are elevated above the sldn level or confined to
`the epidermis and upper dermis, or to protrusions
`of lesions from internal sites.
`surface b., a b. obtained by detaching cells
`from a cutaneous or fl1l.1COSEl surface with a spatv
`ula, cotton swab, or brush.
`bi-op-tome (bi-op’t6rn). A biopsy instrument
`passed through a catheter into the heart to obtain
`tissue for diagnosis. [biopsy + G. tome, a cutting]
`bi-0-rhythm (bi'6-rith—In). A biologically inher-
`ent cyclic variation or recurrence of an. event or
`state, such as the sleep cycle, circadian rhythms,
`or periodic diseases.
`[bio- + G.
`rhyIhnws,-
`rhythm]
`Safety measures ap—
`bi-o-safeaty (b—i’6-saf’te}.
`plied to the handling of biological materials or
`organisms with a known potential
`to cause
`disease in humans.
`Involving the inter-
`hi-ouso-cia] (hi—6—s6’shf1l).
`play of biological and social influences.
`-bi-o-spec-troin-e-try {bi'Eu—spelc~trom’é-tré).
`Spectroscopic determination of the types and
`amounts of various substances -in living tissue or
`fluid from a living body. [bio- + L. spectrum, an
`image, + G. matron, measure]
`bioo-spec-tros-co-py (bi’o~spel<-tros'lc6-pe).
`Spectroscopic examination ofspecirnens of living
`tissue, including fluids removed therefrom. [bio-
`+ L. spectrum, image, + G. skopefi, to examine]
`binousphere (bi’6~sfEr). All
`the regions in the
`world where living organisms are found. {bio- +
`G. sphaira, sphere]
`,
`bi-onsta-tis-tics (bI’o—sta—tis’tiks). The science of
`statistics applied to biological or medical data.
`bi-=0-syn-theosis (bE—6-sin’the—sis). Formation of a
`chemical compound by enzymes, either in the
`organism (in vivo) or by fragments 0! extracts of
`cells (in vitro). SYN biogenesis (2).
`bino-synotliet-ic '{bI’o—sin—thet’ik). Relating to or
`produced by hiosynthesis.
`_
`biao-sysotern (bi’o-sis~tern). A living organism or
`any complete system of living things that can,
`directly or indirectly, interact with others.
`bi-=0-ta (bi46’ta). The collective flora and fauna of
`a region. [Mod 1..., fr. G. bios, life]
`hiuootealem-e-try (bi-6—te1~ern’e-tie). The tech-
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`

`
`
`
`887
`
`TNTC
`
`rep-‘E
`
`_ in _=_______W%l
`
`mucous connective t., a type of connective t.
`little differentiated beyond the mesenchymal
`stage;
`its ground substance of glycoproteins is
`abundant and contains fine coilagenous fibers and
`fibroblasts; in its most characteristic form, it ap-
`pears in the umbilical cord as \Nharton‘s jelly.
`muscular t., a t. characterized by the ability to
`contract upon stimulation; its three varieties are
`skeletal, cardiac, and smooth. sen muscle. SYN
`flesh (2).
`myeloid t., bone marrow consisting of the de-
`velopmental and adult stages of erythrocytes,
`granulocytes, and rnegaitaryocytes in a stroma of
`reticular cells and fibers, with sinusoidal vascular
`channels.
`osseous t., a connective t., the matrix of which
`consists of collagen fibers and ground substance
`and in which are deposited calcium salts (phos-
`phate, carbonate, and some fluoride) in the form
`of an apatite. SYN bone t.
`reticular t., retiform t., a t. in which the ar-
`gyrophilic collagenous fibers form a network and
`that usually has a network of reticular cells asso-
`ciated with the fibers.
`irregular,
`subcutaneous t., a layer of loose,
`connective t.
`immediately beneath the skin and
`closely attached to the corium by coarse fibrous
`bands,
`the retinacula cutis; it contains fat cells
`except in the auiicles, eyelids, penis, and scro-
`l.'L1lTl.
`
`
`-1'Jl.'|'.'l‘;’J:‘r:':r.1-3.1:
`
`
`t‘i-ta-ni-um (Ti) (ti-tE'nE~1‘i1‘r1). A rnetallic ele-
`ment, atomic no. 22, atomic wt. 47.88, used as an
`implant in dental work because of its uniquely
`high level of biocompatibility.
`[Titans in G.
`rnyth., sons of Earth]
`tinter (ti’ter). The standard of strength of a volu-
`rnenic test solution;
`the assay value of an un-
`known measure by volumetric means. [Fr.
`titre,
`standard]
`ti-trate (tifirat). To analyze volurnetrically by a
`solution (the titrant) of lcnown strength to an end
`point.
`Volumetric analysis by
`ti-traation (ti-(:ra’shfin).
`addition of definite amounts of a test solution to a
`solution of the substance being assayed. [Fr. titre,
`standard]
`1. A staggering or
`titouebaotion (tit-yfi-b.i’shfin).
`stumbling in trying to walk. 2. A‘ tremor or shak-
`ing of the head, of cerebellar origin. En titubo,
`pp. —flI'L£.!', to stagger]
`Tl thallium.
`TLC thin-layer chromatography;
`pacity.
`TLD thermoluminescent dosimeter.
`Tm thulium; transport maximum.
`TIVIJ Colloquial for temporcmandibular joint dys-
`fimction.
`trimethopiim; some
`TN? ribothymidylic acid;
`times for deoxyiibothymidylic acid.
`Tl\/IT tarsometatarsal.
`T-my-co-plas-Ina. SYN U1-ecqilcrs-irrrr.
`Tn 1. ocular tension. 2. troponin.
`TNM Abbreviation for tumor—node-metastasis.
`SEE TNM staging.
`TNTC too numerous to count (indicating the find-
`ing of a large number of discrete objects, usually
`
`total
`
`lung ca-
`
`.0’
`
`clinical laboratory test or othercl
`IFS transjugular intrahepatic portosystemic
`lagnflstic
`.re and the reporting of results.
`I W,
`(tin). A metallic element, atomic no 5
`.l”_-ing (tiring). SYN cerclnge. {Eng tire]
`WE 133-710 SYN Slanllum.
`[A3, t'm]'
`.r'sue (tish’fi). A collection of similar cells and
`- Ti'”C1‘1-“'3, tlflCWl'3-
`9;, intercellular substances surrounding them.
`'iaal (tingk-t6r'E-Ell). Relating to C010‘.
`- were are four basic tissues in the body: 1) epi-
`ng. [L. rincrarmr, fr. tingo, to dye]
`rmg malium; 2)
`the connective tissues,
`including
`2 (tingldghfir). An alCOl'10li(: or hydro '
`flm,d_ bone, and cartilage; 3) muscle tissue; and
`solution prepared from vegetable matrai"
`“nerve tissue. [Fr. tissu, woven, fr. L.
`texo,
`to
`cm chemical substances. [see tincmmini
`five]
`.n'E—€i). A fungus infection (de1-mam ht
`adenoid t., SYN lymplintic t.
`? the keratin component of hair, ski]? 3'‘
`adipose t., a connective t. consisting chiefly of
`enera of fungi causing such infectioniagg’
`fatcells surrounded by reticular fibers and ar-
`orum, Trichophyton, and Epidern-mph
`flhoad in lobular groups or along the course of
`ringworm, serpigo (1).
`[L. won-u_ mmfig
`gnabof the smaller blood vessels. sYN-fat (1).
`bae, t, of the beard; occurring as a fume ' molar t., loose, irregularly arranged connec-
`zction or as a granulomatous lesion; :1;
`I
`five t.
`that consists of collagenous and elastic
`lesions are papules and pustules. smfol
`fibers, a protein polysaccharide ground sub-
`barbae, t. sycosis.
`mac, and connective t. cells (fibroblasts, mac~
`hages, mast cells, and sometimes fat cells,
`itis, a common form of fungus iafedlo
`lama cells, leukocytes, and pigment cells).-
`Laip caused by various species of Micro;
`bmie t., SYN osseous t.
`-nd Trichophytcm on or within hair shafig
`cancellous t., latticelike or spongy osseous t.
`g almost exclusively in chiidren land ,
`chm-idroid t., (1) in an adult, t. resembling car-
`rized by irregularly placed and variously L
`tl.Cl'1€S of apparent baldness becausefo '
`‘gage; SYN pseudocartilage.
`(2) in an embryo, an
`Early stage in cartilage formation.
`aaking off at the surface of the scalp‘
`chromaffin t., a cellular t., vascular and well
`black dots, and occasionally Sfythcmai
`ierrna.
`implied with nerves, made up chiefly of chro-
`,,,f_=fn cells;
`it is found in the medulla of the
`upratenal glands and, in smaller collections,
`in
`maparaganglia.
`clmnective t., the supporting or framework t. of
`.2 animal body, formed of fibrous and ground
`-ubstance with more or less numerous cells of
`arious kinds; it is derived from the mesenchyme,
`and this in turn from the rnesoderm; the varieties
`{connective t. are: areolar or loose; adipose;
`ense, regular or irregular, white fibrous; elastic;
`ncous; and lymphoid t.; cartilage; and bone; the
`loud and lymph may be regarded as connective
`‘s the ground substance of which is a liquid. SYN
`lcrstitial t.
`'
`‘
`elastic t., a form of connective t. in which the
`astic fibers predominate; it constitutes the liga-
`euta flava of the vertebrae and the ligamentum
`achae, especially of quadmpeds; it occurs also
`the walls of the arteries and of the bronchial
`e, and connects the cartilages of the larynx.
`erectile t., a t. with numerous vascular spaces
`at may become engorged with blood.
`fibrous t., a t. composed of bundles of collage-
`uas white fibers between which are rows" of
`nnective t. cells; the tendons, ligaments, apo-
`mroses, and some of the membranes, such as
`I‘. dura mater.
`granulation L, vascular connective t. forming
`Efarlular projections on the surface of a healing
`H on.
`“and, ulcer, or inflamed surface. see ALSO gran-
`mflififerent L, undifferentiated, nonspecialized,
`Elllnyonic t.
`laterstitial t., SYN connective t.
`llflphatic t., lymphoid t., a three-dimensional
`l_Worl< of reticular fibers and cells the meshes of
`lilcllare occupied in varying degrees of density
`'1‘ lymphocytes; there is nodular, dfise, and
`56 lymphatic t. sYN adenoid t.
`
`na’ta, syn t. coiporis.
`ports, a well-defined, scaling, macular
`of dermatophytosis that frequently ram,-, .7
`esions and may appear onany part of the -
`N t. circinata.
`,
`"is, a form of t. imbricata occurring in“the'
`iral region,
`including the inner side'of'
`s, the perineal region, and the groin. syn
`narginatum, jock itch.
`'
`‘f
`'ica’ta, an eruption consisting of a nudi-
`:oncemric rings of overlapping scales
`papulosquamous patches scattered over
`‘; it occurs in tropical climates and is
`if the fungus Trichophyton concenrricum.
`311, an inflammatory fungus infectioniof .
`and board, marked by pustules and a
`filtration of the surrounding parts:I1105l
`.y caused by Microspomm aucl.'0uinii.-
`_
`3, dermatophytosis of the feet, especially
`n between the toes, caused by one of the
`hytes, usually a species of Trichophytori
`moplzyton; the disease consists of small
`fissures, scaling, maceration, and eroded
`Fl/ECU the toes and on the plantar sIJl'f_3_"—'5,
`rt; other skin areas may be involved. s_1’N
`foot.
`'
`,
`':
`H"
`iis, SYN t. barbae.
`Iium, ringworm of the nails due to a
`byte.
`e
`e 2
`c’olor, an eruption of tan or brown
`atches on the skin of the ttuul<..0fi5“=
`white, in contrast with hypB1‘P1Em3“t‘d
`exposure to the summer sun; caufied by.
`:‘ Malassezia fiufur in the strat_I1IT1 °°f'_
`h minimal inflammatory l'6flC°1_°_"_-_V5“'”
`versicolor.
`-_
`'
`' U-
`(ti—ni’tfts). A sensation of DOISBS (Ulla
`tling, booming, etc.) in the 33”‘
`';
`
`
`
`
`

`
`m
`
`
`
` ELmmMmmm
`
`EC
`
`mm
`
`
`

`
`
`
`R121.D73
`
`610'l3'21-—dc19
`
`0-6383
`AACR 2 MARC-S
`
`Library of Congress
`
`[8607r85]rev6
`
`Listed here are the latest translated editions of this book together with the languags fol the translations and the
`publishers.
`-
`Italian (27th Edition, reoised)——E.dizioni Scientifiche lnternazionali (ESI), Milan, Italy
`Japanese (27th Edition)—Hirokawa Publishing Company, Tokyo, Japan
`Spanish (27th Edition) (Adaption)—McGraw«l-{ill-Jnteramericana de Espafia, Madrid Spain
`0~7216—2S59—1(Sta11daII3)
`-Dorland’s illustrated Medical Dictionary
`SBJ
`0—7216—5577-7(Deioxe)
`1-» 7215- 5323—5(lnternational)
`
`® 1994 by WB. Saunders Company. Copyright 1900, 1901, and 1903 by W.B. Saunders aid Ccmpany. Copyright 1906,
`1909, 1911, 1913,1915,1917,1919,1921,1923,1927,1929,1932,1935,1938,1941,1944,19t7,19i1,1957,1965,19?4,1981,
`1985, and 1988 by W.B. Saunders Company.
`1
`Copyright under the Uniform Copyright Convention. Simuitaneousiy published incaiada. All copyright renewals
`registered.
`_Derechos reservados coniorme a la ley para la Republica Mexicana.
`All rights reserved. This book is protected by copyright. No part of it may be reprodlcei, St_0'ed in a retrievai SYSIEIH.
`or transmitted in any form or by any means, electronic, mechanical, photocopyingreording, or otherwise, without
`written permission from the pubiisher. Made in the United States of America.
`'
`Some of the words appearing in the Dictionary are proprietary names (trademarks) ev_'€n tloughno reference to this fact
`is made in the text. The appearance of any name without designation as a trademark 1stha’e1O1’e not to be regarded as a
`representation by the editors or publisher that it is not a trademark or is not the subectoi Doprietary rights.
`The use of portions of the text of the United States Pharmacopeia, Twenty-second Revisonpffical from January 1, 1990,
`of the Nt1tionaIFormulmy, Seventeenth Edition, official from January 1, 1990, and of USJN and the USPDictionary ofDrug
`Names 1994 is by permission received from the Board of Trustees of the United StatesPharmB.topeia.l Convention, tnc.
`The said Convention is not responsible for any inaccuracy of quotation, or for any faiée ozmishading implication that
`may arise hy reason oi the separation of excerpts from the original context or by tbsdescfnce resulting from the
`publication of a supplement.
`Library of Congress catalog card number 78-50050
`Last digit is the print number:
`9
`8
`7
`6
`
`5
`
`4
`
`3
`
`2
`
`1
`
`W.B. SAUNDERS COMPANY
`A Division ofHarcourt Brace 6’: Company
`The Curtis Center
`Independence Square West
`Philadelphia, PA 19106
`
`Doriand's illustrated medical dictionary.
`Philadelphia: W.B. Saunders Co.,
`v.: ill.; 27 cm.
`
`Irregular.
`Began publication with 23rd ed.
`Description based on: 26th ed.
`Continues: American iiiustrated medical dictionary.
`
`.
`
`l. Dorland, W.A. Newman
`1. Medicine—Dictionaries.
`(William Alexander Newman), 1864- 1956.
`[DNLM: i. Dictionaries, Medical.
`2. Reference Books,
`Medical}
`
`

`
`
`
`bionornics
`
`200
`
`biotelemgt,
`
`[bi'o- + physiography]
`
`the storing up
`
`the eating
`
`the study of the
`bi-u-nom-ics (bi"o—nom'iks) [bio- + Gr. nomos law]
`relations of organisms to their environment; ecology.
`bi-on-o-my (bi—on’a-me) '[bio- + Gr. nomos law]
`the sum of knowl~
`edge regarding the laws of life.
`—
`bio-nu-ole-on-ics (bi"o-noo"kie-on'iks)
`the study of the biological
`applications of radioactive and rare stable isotopes.
`bio-os~mat-ic (bi"o-oz-mot'il<) [br'o- + osmotic]
`a term applied to
`osmotic pressure phenomena in living organisms.
`bi-aph-a-gism (bi-oi’a-jiz-am) [bio— + Gr. phagein to eat]
`or absorption of living matter.
`bi-oph-a-gous (bi-oi'a-gas)
`feeding on living matter.
`bi-oph-a-gy (bi-0f’a-je) biophagism.
`an
`bio-phn-tom-e-ter (bi"o-fo-tom's-tar) [bfo- + photo- 4- meter]
`instrument for measuring the adaptation of the eye to dark as an
`indication of vitamin A deficiency.
`bio-phys-i-cal (bi”o—l'iz’i-kal) pertaining to biophysics.
`bio-phys-ics (bi-o-liz’iks) [bio- -i- physics]
`the science dealing with
`the application of physic