SIGMA-ALDRICH
`
`sigma-aldrich.com
`
`SAFETY DATA SHEET
`Version 5.9
`Revision Date 06/28/2016
`Print Date 07/27/2016
`
`1. PRODUCT AND COMPANY IDENTIFICATION
`1.1
`Product identifiers
`Product name
`
`Dichloromethane
`
`Product Number
`Brand
`Index-No.
`
`270997
`Sigma-Aldrich
`.602-004-00-3
`
`75-09-2
`CAS-No.
`Relevant identified uses of the substance or mixture and uses advised against
`
`1.2
`
`Identified uses
`
`Laboratory chemicals, Synthesis of substances
`
`1.3
`
`Details of the supplier of the safety data sheet
`
`Company
`
`Sigma-Aldrich
`3050 Spruce Street
`SAINT LOUIS MO 63103
`USA
`
`+1 800-325-5832
`Telephone
`+1 800-325-5052
`Fax
`Emergency telephone number
`
`1.4
`
`Emergency Phone#
`
`(314) 776-6555
`
`2. HAZARDS IDENTIFICATION
`2.1
`Classification of the substance or mixture
`GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
`Skin irritation (Category 2), H315
`Eye irritation (Category 2A), H319
`Carcinogenicity (Category 2), H351
`Specific target organ toxicity - single exposure (Category 3), Respiratory system, Centrai nervous system, H335, H336
`Specific target organ toxicity - repeated exposure, Oral (Category 2), Liver, Blood, H373
`Specific target organ toxicity - repeated exposure, Inhalation (Category 2), Central nervous system, H373
`
`For the full text of the H-Statements mentioned in this Section, see Section 16.
`2.2 GHS Label elements, including precautionary statements
`
`Pictogram
`
`Signal word
`
`Hazard statement(s)
`H315
`H319
`H335
`H336
`H351
`H373
`
`H373
`Sigma-Aldrich - 270997
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`Warning
`
`Causes skin irritation.
`Causes serious eye irritation.
`May cause respiratory irritation.
`May cause drowsiness or di~ziness.
`Suspected of causing cancer.
`May cause damage to organs (Liver, Blood) through prolonged or
`repeated exposure if swallowed.
`May cause damage to organs (Central nervous system) through
`FINCHIMICA EXHIBIT 2017
`ADAMA MAKHTESHIM v. FINCH/MICA
`CASE IPR2016-00577
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`Precautionary statement(s)
`P201
`P202
`
`P260
`P264
`P271
`P280
`
`P302 + P352
`P304 + P340 + P312
`
`P305 + P351 + P338
`
`P308 + P313
`P332 + P313
`P337 + P313
`P362
`P403 + P233
`P405
`P501
`
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`prolonged or repeated exposure if inhaled.
`
`Obtain special instructions before use.
`Do not handle until all safety precautions have been read and
`understood.
`Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
`Wash skin thoroughly after handling.
`Use only outdoors or in a well-ventilated area.
`Wear protective gloves/ protective clothing/ eye protection/ face
`protection.
`IF ON SKIN: Wash with plenty of soap and water.
`IF INHALED: Remove person to fresh air and keep comfortable for
`breathing. Call a POISON CENTER/doctor if you feel unwell.
`IF IN EYES: Rinse cautiously with water for several minutes. Remove
`contact lenses, if present and easy to do. Continue rinsing.
`IF exposed or concerned: Get medical advice/ attention.
`If skin irritation occurs: Get medical advice/ attention.
`If eye irritation persists: Get medical advice/ attention.
`Take off contaminated clothing and wash before reuse.
`Store in a well-ventilated place. Keep container tightly closed.
`Store locked up.
`Dispose of contents/ container to an approved waste disposal plant.
`
`2.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none
`
`3. COMPOSITION/INFORMATION ON INGREDIENTS
`
`3.1
`
`Substances
`Synonyms
`
`Formula
`
`Molecular weight
`CAS-No.
`EC-No.
`Index-No.
`Registration number
`
`Hazardous components
`Component
`
`: Methylene chloride
`DCM
`
`: CH2Cl2
`: 84.93 g/mol
`: 75-09-2
`: 200-838-9
`: 602-004-00-3
`: 01-2119480404-41-XXXX
`
`Classification
`
`Concentration
`
`Methylene chloride
`
`
`
`
`
`Skin Irrit. 2; Eye Irrit. 2A; Carc.
`2; STOT SE 3; STOT RE 2;
`H315, H319, H335, H336,
`H351, H373, H373
`For the full text of the H-Statements mentioned in this Section, see Section 16.
`
`<= 100 %
`
`
`4. FIRST AID MEASURES
`
`4.1 Description of first aid measures
`
`General advice
`Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
`
`If inhaled
`If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
`
`In case of skin contact
`Wash off with soap and plenty of water. Consult a physician.
`
`In case of eye contact
`Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
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`If swallowed
`Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
`
`4.2 Most important symptoms and effects, both acute and delayed
`The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
`
`
`4.3
`
`Indication of any immediate medical attention and special treatment needed
`No data available
`
`
`5. FIREFIGHTING MEASURES
`
`5.1
`
`Extinguishing media
`
`Suitable extinguishing media
`Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
`
`5.2
`
`Special hazards arising from the substance or mixture
`No data available
`
`5.3 Advice for firefighters
`Wear self-contained breathing apparatus for firefighting if necessary.
`
`5.4
`
`Further information
`No data available
`
`
`6. ACCIDENTAL RELEASE MEASURES
`
`6.1
`
`Personal precautions, protective equipment and emergency procedures
`Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate
`personnel to safe areas.
`For personal protection see section 8.
`
`6.2
`
`Environmental precautions
`Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
`
`6.3 Methods and materials for containment and cleaning up
`Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for
`disposal.
`
`6.4 Reference to other sections
`For disposal see section 13.
`
`
`7. HANDLING AND STORAGE
`
`7.1
`
`Precautions for safe handling
`Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
`For precautions see section 2.2.
`
`7.2 Conditions for safe storage, including any incompatibilities
`Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully
`resealed and kept upright to prevent leakage.
`
`Heat sensitive. Handle and store under inert gas.
`
`7.3
`
`Specific end use(s)
`Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
`
`
`8. EXPOSURE CONTROLS/PERSONAL PROTECTION
`
`8.1 Control parameters
`
`Basis
`
`Components with workplace control parameters
`Component
`CAS-No.
`Value
`Control
`parameters
`Potential Occupational Carcinogen
`See Appendix A
`
`
`
`Remarks
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`Methylene chloride
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`75-09-2
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`TWA
`
`USA. ACGIH Threshold Limit Values
`50.000000 ppm
`(TLV)
`
`Central Nervous System impairment
`Carboxyhemoglobinemia
`Substances for which there is a Biological Exposure Index or Indices
`(see BEI® section)
`Confirmed animal carcinogen with unknown relevance to humans
`TWA
`50 ppm
`USA. ACGIH Threshold Limit Values
`
`(TLV)
`Central Nervous System impairment
`Carboxyhemoglobinemia
`Substances for which there is a Biological Exposure Index or Indices
`(see BEI® section)
`Confirmed animal carcinogen with unknown relevance to humans
`Substance listed; for more information see OSHA document
`1910.1052
`Substance listed; for more information see OSHA document
`1910.1052
`See Table Z-2
`PEL
`25.000000 ppm
`
`
`OSHA Specifically Regulated
`Chemicals/Carcinogens
`
`1910.1052
`This section applies to all occupational exposures to methylene
`chloride (MC), Chemical Abstracts Service Registry Number 75-09-
`2, in general industry, construction and shipyard employment.
`Methylene chloride (MC) means an organic compound with chemical
`formula, CH2Cl2. Its Chemical Abstracts Service Registry Number is
`75-09-2. Its molecular weight is 84.9 g/mole
`OSHA specifically regulated carcinogen
`STEL
`125.000000
`OSHA Specifically Regulated
`ppm
`Chemicals/Carcinogens
`
`
`1910.1052
`This section applies to all occupational exposures to methylene
`chloride (MC), Chemical Abstracts Service Registry Number 75-09-
`2, in general industry, construction and shipyard employment.
`Methylene chloride (MC) means an organic compound with chemical
`formula, CH2Cl2. Its Chemical Abstracts Service Registry Number is
`75-09-2. Its molecular weight is 84.9 g/mole
`OSHA specifically regulated carcinogen
`PEL
`25 ppm
`California permissible exposure
`87 mg/m3
`limits for chemical contaminants
`(Title 8, Article 107)
`
`see section 5202
`STEL
`125 ppm
`435 mg/m3
`
`see section 5202
`
`California permissible exposure
`limits for chemical contaminants
`(Title 8, Article 107)
`
`Biological occupational exposure limits
`Component
`CAS-No.
`Parameters
`
`Value
`
`Biological
`specimen
`Urine
`
`Basis
`
`Methylene chloride
`
`75-09-2
`
`
`
`Remarks
`
`Dichlorometh
`ane
`
`0.3000
`mg/l
`
`ACGIH - Biological
`Exposure Indices
`(BEI)
`End of shift (As soon as possible after exposure ceases)
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`Derived No Effect Level (DNEL)
`Application Area
`Exposure
`routes
`
`Health effect
`
`Value
`
`Workers
`Workers
`Workers
`Consumers
`Consumers
`Consumers
`Consumers
`
`Inhalation
`Inhalation
`Skin contact
`Ingestion
`Inhalation
`Skin contact
`Inhalation
`
`Acute systemic effects
`Long-term systemic effects
`Long-term systemic effects
`Long-term systemic effects
`Long-term systemic effects
`Long-term systemic effects
`Acute systemic effects
`
`706 mg/m3
`353 mg/m3
`4750mg/kg BW/d
`0.06mg/kg BW/d
`88.3 mg/m3
`2395mg/kg BW/d
`353 mg/m3
`
`Predicted No Effect Concentration (PNEC)
`Compartment
`
`Soil
`Marine water
`Fresh water
`Marine sediment
`Fresh water sediment
`Onsite sewage treatment plant
`Aquatic intermittent release
`
`8.2
`
`Exposure controls
`
`Value
`
`0.583 mg/kg
`0.194 mg/l
`0.54 mg/l
`1.61 mg/kg
`4.47 mg/kg
`26 mg/l
`0.27 mg/l
`
`Appropriate engineering controls
`Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of
`workday.
`
`Personal protective equipment
`
`Eye/face protection
`Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved
`under appropriate government standards such as NIOSH (US) or EN 166(EU).
`
`Skin protection
`Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
`touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after
`use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
`
`Splash contact
`Material: Fluorinated rubber
`Minimum layer thickness: 0.7 mm
`Break through time: 148 min
`Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
`
`data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method:
`EN374
`If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the
`supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an
`industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It
`should not be construed as offering an approval for any specific use scenario.
`
`Body Protection
`Complete suit protecting against chemicals, The type of protective equipment must be selected according to
`the concentration and amount of the dangerous substance at the specific workplace.
`
`Respiratory protection
`Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-
`purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering
`controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators
`and components tested and approved under appropriate government standards such as NIOSH (US) or CEN
`(EU).
`
`Control of environmental exposure
`Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
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`9. PHYSICAL AND CHEMICAL PROPERTIES
`
`9.1
`
`Information on basic physical and chemical properties
`
`a) Appearance
`
`b) Odour
`
`Form: liquid
`Colour: colourless
`
`No data available
`
`c) Odour Threshold
`
`No data available
`
`d) pH
`
`No data available
`
`e) Melting point/freezing
`point
`
`f)
`
`Initial boiling point and
`boiling range
`
`Melting point/range: -97 °C (-143 °F)
`
`39.8 - 40 °C (103.6 - 104 °F)
`
`g) Flash point
`
`No data available
`
`h) Evaporation rate
`
`0.71
`
`i) Flammability (solid, gas) No data available
`
`j) Upper/lower
`flammability or
`explosive limits
`
`Upper explosion limit: 19 %(V)
`Lower explosion limit: 12 %(V)
`
`k) Vapour pressure
`
`470.9 hPa (353.2 mmHg) at 20.0 °C (68.0 °F)
`
`l) Vapour density
`
`2.93 - (Air = 1.0)
`
`m) Relative density
`
`1.325 g/mL at 25 °C (77 °F)
`
`n) Water solubility
`
`slightly soluble
`
`o) Partition coefficient: n-
`octanol/water
`
`log Pow: 1.25
`
`p) Auto-ignition
`temperature
`
`q) Decomposition
`temperature
`
`556.1 °C (1,033.0 °F)
`662.0 °C (1,223.6 °F)
`
`No data available
`
`r) Viscosity
`
`No data available
`
`s) Explosive properties
`
`No data available
`
`t) Oxidizing properties
`
`No data available
`
`9.2 Other safety information
`
`
`
`Relative vapour density
`
`2.93 - (Air = 1.0)
`
`
`10. STABILITY AND REACTIVITY
`
`10.1 Reactivity
`No data available
`
`10.2 Chemical stability
`Stable under recommended storage conditions.
`Contains the following stabiliser(s):
`2-Methyl-2-butene (>0.005 - <0.015 %)
`
`10.3 Possibility of hazardous reactions
`No data available
`
`10.4 Conditions to avoid
`Heat, flames and sparks. Exposure to sunlight.
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`10.5
`
`Incompatible materials
`Alkali metals, Aluminum, Strong oxidizing agents, Bases, Amines, Magnesium, Strong acids and strong bases, Vinyl
`compounds
`
`10.6 Hazardous decomposition products
`Other decomposition products - No data available
`Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas
`In the event of fire: see section 5
`
`
`11. TOXICOLOGICAL INFORMATION
`
`11.1
`
`Information on toxicological effects
`
`Acute toxicity
`LD50 Oral - Rat - > 2,000 mg/kg
`
`LC50 Inhalation - Rat - 52,000 mg/m3
`
`LD50 Dermal - Rat - > 2,000 mg/kg
`(OECD Test Guideline 402)
`
`No data available
`
`Skin corrosion/irritation
`Skin - Rabbit
`Result: Irritating to skin. - 24 h
`(Draize Test)
`
`Serious eye damage/eye irritation
`Eyes - Rabbit
`Result: Irritating to eyes. - 24 h
`(Draize Test)
`
`Respiratory or skin sensitisation
`No data available
`
`Germ cell mutagenicity
`
`Rat
`DNA damage
`
`Carcinogenicity
`
`Carcinogenicity - Rat - Inhalation
`Tumorigenic:Carcinogenic by RTECS criteria. Endocrine:Tumors.
`
`Limited evidence of carcinogenicity in animal studies
`
`Suspected human carcinogens
`
`OSHA:
`
`OSHA specifically regulated carcinogen (Methylene chloride)
`
`Reproductive toxicity
`
`No data available
`
`Specific target organ toxicity - single exposure
`May cause respiratory irritation.
`May cause drowsiness or dizziness.
`
`Specific target organ toxicity - repeated exposure
`Inhalation - May cause damage to organs through prolonged or repeated exposure. - Central nervous system
`Oral - May cause damage to organs through prolonged or repeated exposure. - Liver, Blood
`
`Aspiration hazard
`No data available
`
`Additional Information
`RTECS: PA8050000
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`Dichloromethane is metabolized in the body producing carbon monoxide which increases and sustains
`carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity of the blood., Acts as a simple
`asphyxiant by displacing air., anesthetic effects, Difficulty in breathing, Headache, Dizziness, Prolonged or repeated
`contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:, Redness, Blurred vision, Provokes
`tears., Effects due to ingestion may include:, Gastrointestinal discomfort, Central nervous system depression,
`Paresthesia., Drowsiness, Convulsions, Conjunctivitis., Pulmonary edema. Effects may be delayed., Irregular
`breathing., Stomach/intestinal disorders, Nausea, Vomiting, Increased liver enzymes., Weakness, Heavy or prolonged
`skin exposure may result in the absorption of harmful amounts of material., Abdominal pain
`To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
`investigated.
`
`Stomach - Irregularities - Based on Human Evidence
`Stomach - Irregularities - Based on Human Evidence
`
`
`12. ECOLOGICAL INFORMATION
`
`LC50 - Pimephales promelas (fathead minnow) - 193.00 mg/l - 96 h
`
`NOEC - Cyprinodon variegatus (sheepshead minnow) - 130 mg/l - 96 h
`
`EC50 - Daphnia magna (Water flea) - 1,682.00 mg/l - 48 h
`
`12.1 Toxicity
`
`Toxicity to fish
`
`
`
`
`Toxicity to daphnia and
`other aquatic
`invertebrates
`
`12.2 Persistence and degradability
`Biodegradability
`Result: < 26 % - Not readily biodegradable.
` (OECD Test Guideline 301C)
`
`12.3 Bioaccumulative potential
`Does not bioaccumulate.
`
`12.4 Mobility in soil
`No data available
`
`12.5 Results of PBT and vPvB assessment
`PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
`
`12.6 Other adverse effects
`
`13. DISPOSAL CONSIDERATIONS
`
`13.1 Waste treatment methods
`
`Product
`Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste
`disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a
`chemical incinerator equipped with an afterburner and scrubber.
`
`Contaminated packaging
`Dispose of as unused product.
`
`
`14. TRANSPORT INFORMATION
`
`DOT (US)
`Class: 6.1
`UN number: 1593
`Proper shipping name: Dichloromethane
`Reportable Quantity (RQ): 1000 lbs
`
`Poison Inhalation Hazard: No
`
`IMDG
`Class: 6.1
`UN number: 1593
`Proper shipping name: DICHLOROMETHANE
`
`IATA
`
`Packing group: III
`
`Packing group: III
`
`EMS-No: F-A, S-A
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`Class: 6.1
`UN number: 1593
`Proper shipping name: Dichloromethane
`
`Packing group: III
`
`
`15. REGULATORY INFORMATION
`
`SARA 302 Components
`No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
`
`SARA 313 Components
`The following components are subject to reporting levels established by SARA Title III, Section 313:
`
`CAS-No.
`Revision Date
`Methylene chloride
`75-09-2
`2007-07-01
`
`CAS-No.
`75-09-2
`
`CAS-No.
`75-09-2
`
`CAS-No.
`75-09-2
`
`CAS-No.
`75-09-2
`
`Revision Date
`2007-07-01
`
`Revision Date
`2007-07-01
`
`Revision Date
`2007-07-01
`
`Revision Date
`2007-09-28
`
`SARA 311/312 Hazards
`Acute Health Hazard, Chronic Health Hazard
`
`Massachusetts Right To Know Components
`
`Methylene chloride
`
`Pennsylvania Right To Know Components
`
`Methylene chloride
`
`New Jersey Right To Know Components
`
`Methylene chloride
`
`California Prop. 65 Components
`WARNING! This product contains a chemical known to the
`State of California to cause cancer.
`Methylene chloride
`
`
`
`
`16. OTHER INFORMATION
`
`Full text of H-Statements referred to under sections 2 and 3.
`
`Carc.
`Eye Irrit.
`H315
`H319
`H335
`H336
`H351
`H373
`Skin Irrit.
`STOT RE
`STOT SE
`
`Carcinogenicity
`Eye irritation
`Causes skin irritation.
`Causes serious eye irritation.
`May cause respiratory irritation.
`May cause drowsiness or dizziness.
`Suspected of causing cancer.
`May cause damage to organs through prolonged or repeated exposure if swallowed.
`Skin irritation
`Specific target organ toxicity - repeated exposure
`Specific target organ toxicity - single exposure
`
`HMIS Rating
`Health hazard:
`Chronic Health Hazard:
`Flammability:
`Physical Hazard
`
`NFPA Rating
`Health hazard:
`Fire Hazard:
`Reactivity Hazard:
`
`2
`*
`0
`0
`
`2
`0
`0
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`Further information
`Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
`The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
`guide. The information in this document is based on the present state of our knowledge and is applicable to the
`product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
`product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling
`or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing
`slip for additional terms and conditions of sale.
`
`
`Preparation Information
`Sigma-Aldrich Corporation
`Product Safety – Americas Region
`1-800-521-8956
`
`Version: 5.9
`
`Revision Date: 06/28/2016
`
`Print Date: 07/27/2016
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