SIGMA-ALDRICH
`
`sigma-aldrich.com
`
`SAFETY DATA SHEET
`Version 4.13
`Revision Date 06/19/2015
`Print Date 07/28/2016
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`1. PRODUCT AND COMPANY IDENTIFICATION
`
`1.1
`
`Product identifiers
`Product name
`
`Dichloroacetic acid
`
`Product Number
`Brand
`Index-No.
`
`054702
`Sigma-Aldrich
`607 -066-00-:-5
`
`CAS-No.
`
`79-43-6
`Relevant identified uses of the substance or mixture and uses advised against
`
`1.2
`
`Identified uses
`
`Laboratory chemicals, Manufacture of substances
`
`1.3
`
`Details of the supplier of the safety data sheet
`
`Company
`
`Sigma-Aldrich
`3050 Spruce Street
`SAINT LOUIS MO 63103
`USA
`
`Telephone
`+1 800-325-5832
`Fax
`+1 800-325-5052
`Emergency telephone number
`
`1.4
`
`Emergency Phone#
`
`(314) 776-6555
`
`2. HAZARDS IDENTIFICATION
`2.1
`Classification of the substance or mixture
`
`GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
`Acute toxicity, Dermal (Category 3), H311
`Skin corrosion (Category 1A), H314
`Serious eye damage (Category 1 ), H318
`Carcinogenicity (Category 2), H351
`Acute aquatic toxicity (Category 1 ), H400
`
`For the full text of the H-Statements mentioned in this Section, see Section 16.
`2.2 GHS Label elements, including precautionary statements
`
`Pictogram
`
`Signal word
`
`Hazard statement(s)
`H311
`H314
`H318
`H351
`H400
`
`Precautionary statement( s)
`P201
`P202
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`Sigma-Aldrich - D54702
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`Danger
`
`Toxic in contact with skin.
`Causes severe skin burns and eye damage.
`Causes serious eye damage.
`Suspected of causing cancer.
`Very toxic to aquatic life.
`
`Obtain special instructions before use.
`Do not handle until all safety precautions have been read and
`understood.
`
`FINCHIMICA EXHIBIT 2018
`ADAMA MAKHTESHIM v. FINCH/MICA
`CASE IPR2016-00577
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`P264
`P273
`P280
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`P281
`P301 + P330 + P331
`P303 + P361 + P353
`
`P304 + P340 + P310
`
`P305 + P351 + P338 + P310
`
`P308 + P313
`P363
`P391
`P405
`P501
`
`
`Wash skin thoroughly after handling.
`Avoid release to the environment.
`Wear protective gloves/ protective clothing/ eye protection/ face
`protection.
`Use personal protective equipment as required.
`IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
`IF ON SKIN (or hair): Remove/ Take off immediately all contaminated
`clothing. Rinse skin with water/ shower.
`IF INHALED: Remove victim to fresh air and keep at rest in a position
`comfortable for breathing. Immediately call a POISON CENTER or
`doctor/ physician.
`IF IN EYES: Rinse cautiously with water for several minutes. Remove
`contact lenses, if present and easy to do. Continue rinsing. Immediately
`call a POISON CENTER or doctor/ physician.
`IF exposed or concerned: Get medical advice/ attention.
`Wash contaminated clothing before reuse.
`Collect spillage.
`Store locked up.
`Dispose of contents/ container to an approved waste disposal plant.
`
`2.3 Hazards not otherwise classified (HNOC) or not covered by GHS
`Rapidly absorbed through skin.
`
`
`3. COMPOSITION/INFORMATION ON INGREDIENTS
`
`3.1
`
`Substances
`Formula
`
`Molecular weight
`CAS-No.
`EC-No.
`Index-No.
`
`Hazardous components
`Component
`
`: C2H2Cl2O2
`: 128.94 g/mol
`: 79-43-6
`: 201-207-0
`: 607-066-00-5
`
`Classification
`
`Concentration
`
`Dichloroacetic acid
`
`
`
`
`
`Acute Tox. 3; Skin Corr. 1A;
`Eye Dam. 1; Carc. 2; Aquatic
`Acute 1; H311, H314, H318,
`H351, H400
`For the full text of the H-Statements mentioned in this Section, see Section 16.
`
`<= 100 %
`
`
`4. FIRST AID MEASURES
`
`4.1 Description of first aid measures
`
`General advice
`Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
`
`If inhaled
`If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
`
`In case of skin contact
`Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim
`immediately to hospital. Consult a physician.
`
`In case of eye contact
`Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.Continue rinsing eyes during
`transport to hospital.
`
`If swallowed
`Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a
`physician.
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`4.2 Most important symptoms and effects, both acute and delayed
`The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
`
`4.3
`
`Indication of any immediate medical attention and special treatment needed
`No data available
`
`
`5. FIREFIGHTING MEASURES
`
`5.1
`
`Extinguishing media
`
`Suitable extinguishing media
`Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
`
`5.2
`
`Special hazards arising from the substance or mixture
`Carbon oxides, Hydrogen chloride gas
`
`5.3 Advice for firefighters
`Wear self-contained breathing apparatus for firefighting if necessary.
`
`5.4
`
`Further information
`No data available
`
`
`6. ACCIDENTAL RELEASE MEASURES
`
`6.1
`
`6.2
`
`Personal precautions, protective equipment and emergency procedures
`Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel
`to safe areas.
`For personal protection see section 8.
`
`Environmental precautions
`Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment
`must be avoided.
`
`6.3 Methods and materials for containment and cleaning up
`Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for
`disposal.
`
`6.4 Reference to other sections
`For disposal see section 13.
`
`
`7. HANDLING AND STORAGE
`
`7.1
`
`Precautions for safe handling
`Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
`For precautions see section 2.2.
`
`7.2 Conditions for safe storage, including any incompatibilities
`Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully
`resealed and kept upright to prevent leakage.
`
`Handle and store under inert gas.
`Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials
`causing chronic effects
`
`7.3
`
`Specific end use(s)
`Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
`
`
`8. EXPOSURE CONTROLS/PERSONAL PROTECTION
`
`8.1 Control parameters
`
`Dichloroacetic acid
`
`79-43-6
`
`TWA
`
`Basis
`
`Components with workplace control parameters
`Component
`CAS-No.
`Value
`Control
`parameters
`USA. ACGIH Threshold Limit Values
`0.500000 ppm
`(TLV)
`
`Upper Respiratory Tract irritation
`Eye irritation
`
`
`
`Remarks
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`Testicular damage
`Confirmed animal carcinogen with unknown relevance to humans
`Danger of cutaneous absorption
`TWA
`0.5 ppm
`USA. ACGIH Threshold Limit Values
`
`(TLV)
`Upper Respiratory Tract irritation
`Eye irritation
`Testicular damage
`Confirmed animal carcinogen with unknown relevance to humans
`Danger of cutaneous absorption
`
`8.2
`
`Exposure controls
`
`Appropriate engineering controls
`Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
`
`Personal protective equipment
`
`Eye/face protection
`Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and
`approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
`
`Skin protection
`Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
`touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after
`use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
`
`Full contact
`Material: Fluorinated rubber
`Minimum layer thickness: 0.7 mm
`Break through time: 480 min
`Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
`
`Splash contact
`Material: Nature latex/chloroprene
`Minimum layer thickness: 0.6 mm
`Break through time: 30 min
`Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M)
`
`data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method:
`EN374
`If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the
`supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an
`industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It
`should not be construed as offering an approval for any specific use scenario.
`
`Body Protection
`Complete suit protecting against chemicals, The type of protective equipment must be selected according to
`the concentration and amount of the dangerous substance at the specific workplace.
`
`Respiratory protection
`Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-
`purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
`If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and
`components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
`
`Control of environmental exposure
`Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
`environment must be avoided.
`
`
`9. PHYSICAL AND CHEMICAL PROPERTIES
`
`9.1
`
`Information on basic physical and chemical properties
`
`a) Appearance
`
`Form: clear, liquid
`Colour: colourless
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`b) Odour
`
`No data available
`
`c) Odour Threshold
`
`No data available
`
`d) pH
`
`1.2 at 129 g/l at 20 °C (68 °F)
`
`e) Melting point/freezing
`point
`
`f)
`
`Initial boiling point and
`boiling range
`
`Melting point/range: 9 - 11 °C (48 - 52 °F) - lit.
`
`194 °C (381 °F) - lit.
`
`g) Flash point
`
`113 °C (235 °F) - closed cup
`
`h) Evaporation rate
`
`No data available
`
`i) Flammability (solid, gas) No data available
`
`j) Upper/lower
`flammability or
`explosive limits
`
`No data available
`
`k) Vapour pressure
`
`0.25 hPa (0.19 mmHg) at 20 °C (68 °F)
`
`l) Vapour density
`
`4.45 - (Air = 1.0)
`
`m) Relative density
`
`1.563 g/cm3 at 25 °C (77 °F)
`
`n) Water solubility
`
`soluble
`
`o) Partition coefficient: n-
`octanol/water
`
`log Pow: 0.942
`
`p) Auto-ignition
`temperature
`
`q) Decomposition
`temperature
`
`No data available
`
`No data available
`
`r) Viscosity
`
`No data available
`
`s) Explosive properties
`
`No data available
`
`t) Oxidizing properties
`
`No data available
`
`9.2 Other safety information
`
`
`
`Relative vapour density
`
`4.45 - (Air = 1.0)
`
`
`10. STABILITY AND REACTIVITY
`
`10.1 Reactivity
`No data available
`
`10.2 Chemical stability
`Stable under recommended storage conditions.
`
`10.3 Possibility of hazardous reactions
`No data available
`
`10.4 Conditions to avoid
`No data available
`
`10.5
`
`Incompatible materials
`Strong oxidizing agents, Strong bases, Strong reducing agents
`
`10.6 Hazardous decomposition products
`Other decomposition products - No data available
`In the event of fire: see section 5
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`11. TOXICOLOGICAL INFORMATION
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`11.1
`
`Information on toxicological effects
`
`Acute toxicity
`LD50 Oral - Rat - 2,820 mg/kg
`
`Inhalation: No data available
`
`LD50 Dermal - Rabbit - 799 mg/kg
`
`No data available
`
`Skin corrosion/irritation
`Skin - Rabbit
`Result: Severe skin irritation - 24 h
`
`Serious eye damage/eye irritation
`No data available
`
`Respiratory or skin sensitisation
`No data available
`
`Germ cell mutagenicity
`No data available
`
`Carcinogenicity
`
`Limited evidence of carcinogenicity in animal studies
`
`
`
`IARC:
`
`2B - Group 2B: Possibly carcinogenic to humans (Dichloroacetic acid)
`
`NTP:
`
`OSHA:
`
`No component of this product present at levels greater than or equal to 0.1% is identified as a
`known or anticipated carcinogen by NTP.
`
`No component of this product present at levels greater than or equal to 0.1% is identified as a
`carcinogen or potential carcinogen by OSHA.
`
`Reproductive toxicity
`No data available
`
`No data available
`
`Specific target organ toxicity - single exposure
`No data available
`
`Specific target organ toxicity - repeated exposure
`No data available
`
`Aspiration hazard
`No data available
`
`Additional Information
`RTECS: AG6125000
`
`Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin.,
`Cough, Shortness of breath, Headache, Nausea
`
`
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`12. ECOLOGICAL INFORMATION
`
`12.1 Toxicity
`
`Toxicity to daphnia and
`other aquatic
`invertebrates
`
`EC50 - Daphnia magna (Water flea) - 106 - 2,600 mg/l - 24 h
`
`12.2 Persistence and degradability
`No data available
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`12.3 Bioaccumulative potential
`No data available
`
`12.4 Mobility in soil
`No data available
`
`12.5 Results of PBT and vPvB assessment
`PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
`
`12.6 Other adverse effects
`An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
`Very toxic to aquatic life.
`
`An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
`
`Very toxic to aquatic life.
`
`
`13. DISPOSAL CONSIDERATIONS
`
`13.1 Waste treatment methods
`
`Product
`Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste
`disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a
`chemical incinerator equipped with an afterburner and scrubber.
`
`Contaminated packaging
`Dispose of as unused product.
`
`
`14. TRANSPORT INFORMATION
`
`Packing group: II
`
`DOT (US)
`Class: 8
`UN number: 1764
`Proper shipping name: Dichloroacetic acid
`Reportable Quantity (RQ):
`
`Poison Inhalation Hazard: No
`
`IMDG
`Packing group: II
`Class: 8
`UN number: 1764
`Proper shipping name: DICHLOROACETIC ACID
`Marine pollutant:yes
`
`IATA
`Class: 8
`UN number: 1764
`Proper shipping name: Dichloroacetic acid
`
`Packing group: II
`
`EMS-No: F-A, S-B
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`15. REGULATORY INFORMATION
`
`SARA 302 Components
`No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
`
`SARA 313 Components
`This material does not contain any chemical components with known CAS numbers that exceed the threshold (De
`Minimis) reporting levels established by SARA Title III, Section 313.
`
`SARA 311/312 Hazards
`Acute Health Hazard, Chronic Health Hazard
`
`Massachusetts Right To Know Components
`No components are subject to the Massachusetts Right to Know Act.
`
`Pennsylvania Right To Know Components
`
`Dichloroacetic acid
`
`New Jersey Right To Know Components
`
`Dichloroacetic acid
`
`Sigma-Aldrich - D54702
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`
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`CAS-No.
`79-43-6
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`CAS-No.
`79-43-6
`
`Revision Date
`2007-03-01
`
`Revision Date
`2007-03-01
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`California Prop. 65 Components
`WARNING! This product contains a chemical known to the
`State of California to cause cancer.
`Dichloroacetic acid
`
`
`WARNING: This product contains a chemical known to the
`State of California to cause birth defects or other reproductive
`harm.
`Dichloroacetic acid
`
`
`CAS-No.
`79-43-6
`
`Revision Date
`2013-12-20
`
`CAS-No.
`79-43-6
`
`Revision Date
`2013-12-20
`
`
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`16. OTHER INFORMATION
`
`Full text of H-Statements referred to under sections 2 and 3.
`
`Acute Tox.
`Aquatic Acute
`Carc.
`Eye Dam.
`H311
`H314
`H318
`H351
`H400
`Skin Corr.
`
`Acute toxicity
`Acute aquatic toxicity
`Carcinogenicity
`Serious eye damage
`Toxic in contact with skin.
`Causes severe skin burns and eye damage.
`Causes serious eye damage.
`Suspected of causing cancer.
`Very toxic to aquatic life.
`Skin corrosion
`
`HMIS Rating
`Health hazard:
`Chronic Health Hazard:
`Flammability:
`Physical Hazard
`
`NFPA Rating
`Health hazard:
`Fire Hazard:
`Reactivity Hazard:
`
`3
`*
`1
`0
`
`3
`1
`0
`
`Further information
`Copyright 2015 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
`The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
`guide. The information in this document is based on the present state of our knowledge and is applicable to the
`product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
`product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling
`or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing
`slip for additional terms and conditions of sale.
`
`
`Revision Date: 06/19/2015
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`Print Date: 07/28/2016
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`Preparation Information
`Sigma-Aldrich Corporation
`Product Safety – Americas Region
`1-800-521-8956
`
`Version: 4.13
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`
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`Sigma-Aldrich - D54702
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