ANNE SKAJA ROBINSON
`Chair of Chemical and Biomolecular Engineering
`Catherine and Henry Boh Professor in Engineering
` (504) 865-5775 PH; (504) 865-8779 FAX asr@tulane.edu
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`EDUCATION
`1994 Ph.D., Chemical Engineering
`1989 M.S., Chemical Engineering
`1988 B.S., Chemical Engineering
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`University of Illinois at Urbana-Champaign
`The Johns Hopkins University
`The Johns Hopkins University
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`Positions and Employment
`1994-1997 Massachusetts Institute of Technology
`Department of Biology, Postdoctoral Fellow, Advised by Prof. Jonathan King.
`1997-2003 University of Delaware
`Assistant Professor, Chemical Engineering
`2003-2008 University of Delaware
`Associate Professor, Chemical Engineering
`2008-2011 University of Delaware
`Professor of Chemical Engineering and
`Associate Chair of Biochemical Engineering
`2012-present University of Delaware
`Adjunct Professor, Chemical and Biomolecular Engineering
`2012-present Tulane University
`Catherine and Henry Boh Professor of Engineering
`Chair of Chemical and Biomolecular Engineering
`Awards and Honors
` NIH Post-doctoral Fellowship
`1996-1997
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` DuPont Young Professor Award
`2000-2003
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`2000-2005
` NSF CAREER/PECASE Award
`2002-2003
` Outstanding Junior Faculty Member, College of Engineering, Univ. of
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` Delaware
`2011
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`Fellow, American Institute for Medical and Biological Engineering
`2012
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`Van Lanen Award, American Chemical Society BIOT Division
`2015
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`Perlman Awardee, American Chemical Society (ACS) BIOT division
`2015
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`Biotechnology Progress Award for Excellence in Biological Engineering
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`Publication, Society for Biological Engineering (SBE), an AIChE
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`Technological Community
`2016
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`Fellow, American Institute of Chemical Engineers
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`PATENTS
`A) Kelly, R.M., A.K.S. Robinson, I.I. Blumentals, S.H. Brown, and C.B. Anfinsen. “Proteolytic
`Enzymes from Hyperthermophilic Bacteria and Processes for Their Production.” Patent #
`5,242,817. Filed 9/12/89. Accepted 9/7/93. Licensed to Takara Shuzo.
`B) Robinson, A.S. and K.D. Wittrup. “Methods for Increasing Secretion of Overexpressed Proteins.”
`Patent # 5,773,245. Filed 10/92. Accepted 6/30/98.
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`APOTEX EX1049
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`Robinson, A.S.
`C) Robinson, A.S., D. Foguel, J.L. Silva, C.R. Robinson. “Use of Hydrostatic Pressure to Inhibit and
`Reverse Protein Aggregation and Facilitate Protein Refolding.” Patent applied for, 60/161,035.
`Filed 10/99. Issued 11/10/09.
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`BOOK PUBLICATION
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`1)
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`2)
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`Russell, T.W.F., Robinson, A.S., and Wagner, N.J., (2008) Mass and Heat Transfer: Analysis of
`Mass Contactors and Heat Exchangers, Cambridge University Press, Cambridge, UK
`(www.cambridge.org/9780521886703).
`Robinson, A.S., ed (2011) Production of Membrane Proteins – Strategies for Expression and
`Isolation, Wiley VCH (http://onlinelibrary.wiley.com/book/10.1002/9783527634521)
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`JOURNAL PUBLICATIONS
`1)
`Blumentals, I. I., R. M. Kelly, A. K. Skaja [Robinson] and J. Shiloach (1987) "Effect of Culturing
`Conditions on the Production of Exotoxin A by Pseudomonas aeruginosa." Ann N Y Acad. Sci.
`506, 663-668.
`Blumentals, I. I., A. S. Robinson and R. M. Kelly (1990) "Characterization of Sodium Dodecyl
`Sulfate Resistant Proteolytic Activity in the Hyperthermophilic Archaebacterium Pyrococcus
`furiosus." Appl. Envir. Microbiol. 56, 1992-1998.
`Blumentals, I.I., S.H. Brown, R.N. Schicho, A.K. Skaja [Robinson], H.R. Costantino, and R.M.
`Kelly. (1990) “The Hyperthermophilic Archaebacterium, Pyrococcus furiosus: Development of
`Culturing Protocols, Perspectives on Scale-Up, and Potential Applications.” Ann. N.Y. Acad. Sci.,
`589, 301-314.
`Robinson, A.S. and K.D. Wittrup (1993) “Role of the Protein Folding Chaperone BiP in
`Secretion of Foreign Proteins in Eucaryotic Cells.” in Protein Folding: In vivo and In vitro.
`ACS Symposium Series 526. Jeffrey Cleland, Ed., 121-132.
`Robinson, A.S., V. Hines, and K.D. Wittrup(1994) “Overexpression of Protein Disulfide
`Isomerase Increases Secretion of Foreign Proteins in the Yeast Saccharomyces cerevisiae.”
`Bio/Tech. 12, 381-384.
`6) Wittrup, K.D., A.S. Robinson, R.N. Parekh, and K.J. Forrester (1994) “Existence of an Optimal
`Expression Level for Secretion of Foreign Proteins in Yeast.” Ann. N.Y. Acad. Sci. 745, 321-330.
`Robinson, A.S. and K.D. Wittrup.(1995) “Constitutive Overexpression of Secreted Heterologous
`Proteins Decreases Extractable BiP and PDI Levels in Saccharomyces cerevisiae.” Biotech Prog.
`11, 171-177.
`King, J., C. Haase-Pettingell, A.S. Robinson, M. Speed, and A. Mitraki (1996) “Thermolabile
`Folding Intermediates: Inclusion Body Precursors and Chaperonin Substrates” FASEB J., 10, 57-
`66.
`Robinson, A.S., J.A. Bockhaus, A.C. Voegler, and K.D. Wittrup (1996) “Reduction of BiP levels
`decreases heterologous protein secretion in Saccharomyces cerevisiae” J. Biol. Chem. 271,
`10017-10022.
`Robinson, A.S. and D.A. Lauffenburger (1996) “Model for ER Chaperone Dynamics and
`Secretory Protein Interactions.” AIChE J. 42, 1443-1453.
`Robinson, A.S. and J. King (1997) “Disulfide-Bonded Intermediate on the Folding and Assembly
`Pathway of a Non-Disulfide Bonded Protein.” Nature Struct. Biol., 4, 450-455.
`Foguel, D., Robinson, C.R., Caetano de Sousa Jr., P., Silva, J. L. and A. S. Robinson (1999),
`“Hydrostatic Pressure Rescues Protein Aggregates”, Biotech. Bioeng. 63, 552-558.
`13) Haase-Pettingell, C., Betts, S., Raso, S.W., Stuart, L., Robinson, A. and J. King (2001), “Role for
`Cysteine Residues in the In Vivo Folding and Assembly of the Phage P22 Tailspike,” Protein Sci.
`10, 397-410.
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`14) Kauffman, K., P. Dhurjati, A.S. Robinson, and F.J. Doyle III “Framework for Modeling
`Information Flow in Biological Processes: Application to the Unfolded Protein Response.” Proc.
`IFAC Conf. Comput. Appl. Biotech (CAB), 2001.
`15) Kauffman, K., Pridgen, E.M. , Doyle, F.J. III, Dhurjati, P., and A.S. Robinson (2002) “Decreased
`Protein Expression and Oscillating BiP Levels Result during Heterologous Protein Expression in
`S. cerevisiae,” Biotech. Prog., 18, 942-940 DOI: 10.1021/bp025518g
`Sinacola, J. and A.S. Robinson (2002) “Rapid refolding and polishing of single-chain antibodies
`from E. coli inclusion bodies” Protein Exp. Purif., Vol. 26, No. 2, Nov 2002, pp. 301-308.
`Smith, J.D. and A.S. Robinson (2002) “Overexpression of an archael enzyme in a eucaryotic
`host: A secretion bottleneck at the ER,” Biotech. Bioeng., 79, 7, p. 713-723. DOI:
`10.1002/bit.10367
`Lefebvre, B.G., and A.S. Robinson (2003), “Pressure treatment of tailspike aggregates rapidly
`produces on-pathway folding intermediates,” Biotech. Bioeng, 82, 5, p. 595-604. DOI:
`10.1002/bit.10607
`19) Danek, B.L., and A. S. Robinson (2003) “Non-native interactions between cysteines direct
`productive assembly of P22 tailspike protein,” Biophys J., 85, 5, p. 1-11.
`Butz, J., Niebauer, R. T., and A.S. Robinson (2003), “Co-expression of molecular chaperones
`does not improve the heterologous expression of mammalian G-protein coupled receptor
`expression in yeast,” Biotech. Bioeng., 84, 3, p. 292-304. DOI: 10.1002/bit.10771.
`21) Gage, M.J. and A.S. Robinson (2003) “C-terminal Hydrophobic Interactions Play a Critical role
`in Oligomeric Assembly of the P22 Tailspike Trimer,” Protein Sci., 12, 12, p. 2732-47.
`Smith, J.D., Tang, B.C. , and A.S. Robinson (2004) “Protein disulfide isomerase, but not binding
`protein, overexpression enhances secretion of a non-disulfide-bonded protein in yeast”, Biotech.
`Bioeng., 85, 3, p. 340-50. DOI: 10.1002/bit.10853
`23) Niebauer, R. T. and A.S. Robinson (2004) “Saccharomyces cerevisiae protein expression: From
`protein production to protein engineering” in Protein Expression Technologies, Horizon
`Scientific Press, François Baneyx, ed.
`Lefebvre, B.G., Gage, M.J., and A.S. Robinson (2004) “Maximizing Recovery of Native Protein
`from Aggregates by Optimizing Pressure Treatment,” Biotechnology Progress, 20, 2, p. 623-629.
`Lefebvre, B.G., Comolli, N.K. , Gage, M.J. and A.S. Robinson (2004), “Pressure dissociation
`studies provide insight into oligomerization competence of temperature-sensitive mutants of P22
`tailspike,” Protein Sci., 13 (6) 1538-46. DOI: 10.1110/ps.03579304
`26) Danek, B.L. and A. S. Robinson (2004) “P22 tailspike trimer assembly is governed by interchain
`redox associations,” Biochem. Biophys. Acta, 1700(1):105-16.
`27) Niebauer, R.T., Wedekind, A. and A.S. Robinson (2004) “Decreases in yeast expression yields of
`the human adenosine receptor are a result of translational or post-translational events”, Protein
`Exp. Purif., 37 (1) 134-143. DOI: 10.1016/j.pep.2004.06.001
`28) Xu, P., Raden, D., Doyle, F.J. III, and A.S. Robinson (2005) “Analysis of unfolded protein
`response during single-chain antibody expression in Saccharomyces cerevisiae reveals different
`roles for BiP and PDI in folding”, Metabolic Engineering, 7 (4) 269-279.
`29) Gage, M.J., Zak, J. and A.S. Robinson (2005) “Three Amino Acids that are Critical to Formation
`and Stability of the P22 Tailspike Trimer”, Protein Science, 14 (9) 2333-43. DOI:
`10.1110/ps.051394605
`Smith, J.D., Richardson, N.E. and A.S. Robinson (2005) “Elevated expression temperature in a
`mesophilic host results in increased secretion of a hyperthermophilic enzyme and decreased cell
`stress,” Biochem. Biophys. Acta, 1752 (1) 18-25.
`Raden, D., Hildebrandt, S, Xu, P., Bell, E. , Doyle, III, F.J. and A.S. Robinson (2005), “Analysis
`of cellular response to protein overexpression.” IEE Proceedings: Systems Biology 152 (4) 285-
`289. PMID: 16986272
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`32) Niebauer, R. T., and A.S. Robinson (2006) “Exceptional total and functional yields of the human
`adenosine (A2a) receptor expressed in the yeast Saccharomyces cerevisiae”, Prot. Exp. Purif., 46,
`p. 204-211.
`33) Gage, M.J, Lefebvre, B.G., and A.S. Robinson (2006) “Determinants of Protein Folding and
`Aggregation in P22 Tailspike,” in Misbehaving Proteins, ACS Publications, eds. Regina Murphy
`and Amos Tsai.
`34) Kim, J. and Robinson, A.S. (2006) Dissociation of intermolecular disulfide bonds in P22 tailspike
`protein intermediates in the presence of SDS, Protein Science, 15 (7), p. 1791-3.
`35) Wedekind, A.L. , O’Malley, M., Niebauer, R.T., and Robinson, A.S. (2006) Optimization of the
`Human Adenosine A2a Receptor Yields in Saccharomyces cerevisiae, Biotechnology Progress,
`22(5):1249-55. PMID:17022661; DOI: 10.1021/bp050431r
`Powers, S.L., Robinson, C.R., and Robinson, A.S. (2007) Denaturation of an Extremely Stable
`Hyperthermophilic Protein Occurs via a Dimeric Intermediate, Extremophiles, 11(1):179-89.
`Forsten-Williams, K.F., Cassino, T.R, Delo, L.J., Bellis, A.D., Robinson, A.S., and Ryan, T.E.,
`(2007) Enhanced Insulin-like Growth Factor-I (IGF-I) Cell Association at Reduced pH is
`Dependent on IGF Binding Protein-3 (IGFBP-3) Interaction, Journal of Cellular Physiology,
`210(2):298-308.
`Famá, M.C., Raden, D., Zacchi, N., Lemos, D.R., Robinson, A.S., and Silberstein, S. (2007) “The
`Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J
`domain is required to preserve the folding capacity of the endoplasmic reticulum” Biochim
`Biophys Acta, 1773(2):232-42.
`Bane, S.E., Velasquez, J.E. , and A.S. Robinson (2007) “Expression and purification of milligram
`levels of inactive G-protein coupled receptors in E. coli”, Protein Expression and Purification,
`52(2):348:355. PMID: 17166740; DOI: 10.1016/j.pep.2006.10.017
`40)
`Powers, S.L. and A.S. Robinson (2007) “PDI Improves Secretion of Redox-Inactive -
`glucosidase”, Biotech Prog., Mar-Apr;23(2):364-9. E-pub Feb 22, DOI: 10.1021/bp060287p
`41) McCusker, E., Bane, S.E., O’Malley, M., and A.S. Robinson (2007), “Heterologous GPCR
`expression: A bottleneck to obtaining crystal structures”, Biotech Progress, May-Jun;23(3):540-7.
`PMID:17397185
`42) O’Malley, M., Lazarova, T., Britton, Z.T., and Robinson, A.S. (2007) “High-level expression in
`Saccharomyces cerevisiae enables isolation and spectroscopic characterization of functional
`human adenosine A2a receptor”, J. Struct Biol., 159(2): 166-178. PMID: 17591446
` McCusker, E., and Robinson, A.S., (2008) Refolding of G protein α subunits from inclusion
`bodies expressed in Escherichia coli, Protein Exp. Purif., Apr;58(2): 342-55. PMID: 18249008
`44) Hildebrandt, S., D. Raden, L. Petzold, A.S. Robinson, and F.J. Doyle III (2008) “A top-down
`approach to mechanistic biological modeling: application to the single-chain antibody folding
`pathway”, Biophysical Journal, 95(8):3535-58. Epub 2008 Jul 18. PMID: 18641066
`45) Webber T, Gurung S, Saul J, Baker T, Spatara M, Freyer M, Robinson AS, Gage MJ (2009) “The
`C-terminus of the P22 tailspike protein acts as an independent oligomerization domain for
`monomeric proteins.”, Biochem J. May 1;419(3):595-602. PMID: 19196242
`Spatara ML, Roberts CJ, Robinson AS (2009) “Kinetic folding studies of the P22 tailspike beta-
`helix domain reveal multiple unfolded states.” Biophys Chem. 141(2-3):214-21. PMID: 19258192
`47) Xu, P. and Robinson, A.S. (2009) “Decreased secretion and unfolded protein response up-
`regulation are correlated with intracellular retention for single-chain antibody variants produced in
`yeast” Biotech & Bioeng, 104(1):20-9. PMID: 19415776
`48) O'Malley MA, Mancini JD, Young CL, McCusker EC, Raden D, Robinson AS.(2009) “Progress
`toward heterologous expression of active G-protein-coupled receptors in Saccharomyces
`cerevisiae: Linking cellular stress response with translocation and trafficking.” Protein Sci.
`18(11):2356-2370. PMID: 19760666; DOI: 10.1002/pro.246
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`Spatara, ML and Robinson, AS (2010) “Transgenic mouse and cell culture models demonstrate a
`lack of mechanistic connection between endoplasmic reticulum stress and tau dysfunction”
`Journal of Neuroscience Research, 88(9):1951-61. PMID: 20143409
`50) O’Malley, MA, AN Naranjo, T Lazarova, AS Robinson (2010) “Analysis of Adenosine A2a
`Receptor Stability: Effects of Ligands and Disulfide Bonds”, Biochemistry, Nov 2;49(43):9181-9.
`PMID: 20853839
`51) Yuraszeck, TM, Neveu, P, Rodriguez-Fernandez, M, Robinson, AS, Kosik, KS, and FJ Doyle III
`(2010) Vulnerabilities in the Tau Network and The Role of Ultrasensitive Points in Tau
`Pathophysiology, PLoS Computational Biology, 6(11): e1000997.
`doi:10.1371/journal.pcbi.1000997 (with cover art)
`52) O'Malley, MA, Helgeson, ME, Wagner, NJ and AS Robinson (2011) Morphology and
`Composition of Cholesterol-rich Micellar Nanostructures Determine Transmembrane Protein
`(GPCR) Activity, Biophysical Journal, 100(2): L11-13. PMID: 3021673.
`Sahin, E, JL Jordan, ML Spatara, AN Naranjo, WF Weiss IV, AS Robinson, EJ Fernandez, CJ
`Roberts (2011) “Computational Design and Biophysical Characterization of Aggregation-
`Resistant Point Mutations for γD Crystallin Illustrate a Balance of Conformational Stability and
`Intrinsic Aggregation Propensity”, Biochemistry, Feb 8;50(5):628-39. PMID: 21184609
`54) Young CL, Yuraszeck T, Robinson AS (2011) “Decreased secretion and unfolded protein
`response upregulation,” Methods Enzymol. 491:235-60. PMID: 21329804
`Robinson, A. (2011) “New Tools for Breaking Barriers to GPCR Expression in E. coli” Journal of
`Molecular Biology. 408 (4): 597-598 PMID: 21420418
`Britton, Z., Young, C., Can, Ö., McNeely, P., Naranjo, A. and Robinson, A. S.(2012) Membrane
`Protein Expression in Saccharomyces cerevisiae, in Production of Membrane Proteins: Strategies
`for Expression and Isolation (ed A. S. Robinson), Wiley-VCH Verlag GmbH & Co. KGaA,
`Weinheim, Germany. doi: 10.1002/9783527634521.ch2
`57) O’Malley, Michelle A., Matthew E. Helgeson, Norman J. Wagner, Anne S. Robinson (2011)
`“Toward Rational Design of Protein Detergent Complexes: Determinants of Mixed Micelles that
`are Critical for the in vitro Stabilization of a G-protein Coupled Receptor”, Biophysical Journal,
`101 (8): 1938-1948. DOI: 10.1016/j.bpj.2011.09.018 PMID: 22004748
`58) Griesemer, M, Young, CL, Doyle III, FJ, Robinson, AS and L Petzold (2012) Spatial Localization
`of Chaperone Distribution in the Endoplasmic Reticulum of Yeast, IET Systems Biology, 6(2):54-
`63. http://dx.doi.org/10.1049/iet-syb.2011.0006
`59) Young, CL, ZT Britton, AS Robinson (2012) “Recombinant Protein Expression and Purification:
`A Comprehensive Review of Affinity Tags and Microbial Applications” Biotechnology Journal,
`May;7(5):620-34. doi: 10.1002/biot.201100155. Epub 2012 Jan 10. PMID: 22442034
`60) Young, CL, DL Raden, J Caplan, K Czymmek, AS Robinson (2012) “Cassette Series Designed for
`Live-Cell Imaging of Proteins and High Resolution Techniques in Yeast”, Yeast, Mar;29(3-
`4):119-36. doi: 10.1002/yea.2895. Epub 2012 Apr 4. PMID: 22473760
`Britton, ZT, EI Hanle, and AS Robinson (2012) An Expression and Purification System for the
`Biosynthesis of Adenosine Receptor Peptides for Biophysical and Structural Characterization,
`Protein Exp. Purif., 84:224-235. PMID: 22722102; DOI: 10.1016/j.pep.2012.06.005
`62) McNeely, P.M., Naranjo, A.N., and A.S. Robinson (2012) Structure-function studies with G-
`protein coupled receptors as a paradigm for improving drug discovery and therapeutic
`development, Biotechnology Journal, 7(12): 1451-1461. DOI: 0.1002/biot.201200076 PMID:
`23213015
`63) Young, CL, DL Raden, AS Robinson (2013) Analysis of ER Resident Proteins in S. cerevisiae:
`Implementation of H/KDEL Retrieval Sequences, Traffic, 14(4):365-81. DOI: 10.1111/tra.12041.
`PMID: 23324027
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`64) Morozova, OA, ZM March, AS Robinson, and DW Colby (2013) Conformational features of tau
`fibrils from Alzheimer's disease brain are faithfully propagated by unmodified recombinant
`protein, Biochemistry, 52(40):6960-7. http://dx.doi.org/10.1021/bi400866w PMID: 24033133
`65) Maurer, Ronald W., Alan K Hunter, Xiangyang Wang, William K Wang, Anne S Robinson, and
`Christopher J. Roberts (2013) Folding and aggregation of a multi-domain engineered
`immunotoxin, Biochemical Engineering Journal, 81: 8-14.
`http://dx.doi.org/10.1016/j.bej.2013.09.015.
`Blanco, M, Sahin, E, Robinson, A, Roberts, C (2013) Coarse-Grained Model for Colloidal Protein
`Interactions, B22, and Protein Cluster Formation, The Journal of Physical Chemistry, Part B, Dec
`19;117(50):16013-28. doi: 10.1021/jp409300j PMID: 24289039
`67) Maurer, RW, AK Hunter, AS Robinson, and CJ Roberts (2014) Aggregates of alpha-
`chymotrypsinogen anneal to access more stable states, Biotechnology & Bioengineering,
`111 (4): 782-791. doi: 10.1002/bit.25129 PMID: 24122552
`St. Amand, MM, Ogunnaike, BA, and Robinson, AS (2014) Development of At-Line Assay to
`Monitor Charge Variants of mAbs During Production, Biotechnology Progress, 30: 249–255.
`DOI: 10.1002/btpr.1848 PMID: 24382831
`St. Amand, MM, K Tran, D Radhakrishnan, AS Robinson, BA Ogunnaike (2014) Controllability
`Analysis of Protein Glycosylation in CHO cells, PLoS One, 9(2): e87973. DOI:
`10.1371/journal.pone.0087973
`70) Wu, H, R Kroe-Barrett, S Singh, AS Robinson, CJ Roberts (2014) Competing aggregation
`pathways for monoclonal antibodies, FEBS Letters 588(6): 936-941.
`http://dx.doi.org/10.1016/j.febslet.2014.01.051
`JA Costanzo, CJ O’Brien, K Tiller, E Tamargo, AS Robinson, CJ Roberts, and EJ Fernandez,
`(2013) Computational Design to Control Protein Aggregation Rates Through Conformational
`Stability, Protein Eng, Des, & Sel, 27 (5): 157-167. 10.1093/protein/gzu008
`St. Amand, MM, D Radhakrishnan, AS Robinson, BA Ogunnaike (2014) Identification of
`Manipulated Variables for a Glycosulation Control Strategy, Biotech Bioeng, in press. Available
`online: 22 MAY 2014 DOI: 10.1002/bit.25251
`73) Griesemer, M., Young, C., Robinson, A.S., Petzold, L. (2014) BiP Clustering Facilitates Protein
`Folding in the Endoplasmic Reticulum, PLOS Computational Biology, 10(7):1-16,
`10.1371/journal.pcbi.1003675
`74) Young, CL and AS Robinson (2014) Protein Folding and Secretion: Mechanistic Insights
`Advancing Recombinant Protein Production in S. cerevisiae, Current Opinion in Biotechnology,
`30: 168-177. Available online 15 July 2014 DOI: 10.1016/j.copbio.2014.06.018
`75) Naranjo, AN, A Chevalier, GD Cousins, E Ayettey, EC McCusker, C Wenk, AS Robinson (2015)
`Conserved disulfide bond is not essential for the adenosine A2A receptor: extracellular cysteines
`influence receptor distribution within the cell and ligand-binding recognition, BBA
`Biomembranes, 1848: 603-614 Available on-line Dec 5 2014 DOI:
`10.1016/j.bbamem.2014.11.010
`Blocker, KM, ZT Britton, AN Naranjo, PM McNeely, CL Young, AS Robinson (2015)
`Recombinant G protein-coupled receptor expression in Saccharomyces cerevisiae for protein
`characterization, in “Membrane Proteins – Production and Function Characterization”, Methods
`Enzymol., 556:165-83. DOI: 10.1016/bs.mie.2014.12.025
`77) Wu, H, K Truncali, J Ritchie, R Kroe-Barrett, S Singh, AS Robinson, and CJ Roberts (2015)
`Weak protein interactions and pH- and temperature-dependent aggregation of human Fc1, mAbs, 7
`(6): 1072-1083 DOI: 10.1080/19420862.2015.1079678
`78) O'Brien, C, M Blanco, J Costanzo, M Enterline, EF Fernandez, AS Robinson,* CJ Roberts* (2016)
`Modulating Non-Native Aggregation and Electrostatic Protein-Protein Interactions with
`Computationally Designed Single-Point Mutations, Prot Eng Des & Sel, in press, doi:
`10.1093/protein/gzw010
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`79) Naranjo, AN, PM McNeely, J Katsaras, AS Robinson* (2016) Impact of purification conditions
`and history on A2A adenosine receptor activity: The role of CHAPS and lipids, Prot Exp Purif, in
`press. DOI: 10.1016/j.pep.2016.05.015
`St. Amand, MM, J Hayes, D Radhakrishnan, J Fernandez, B Meyer, AS Robinson, BA
`Ogunnaike* (2016) Identifying a Robust Design Space for Glycosylation during Monoclonal
`Antibody Production, Biotech Prog, in press.
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`PEER-REVIEWED CONFERENCE PROCEEDINGS
`1)
`Hildebrandt, S., D. Raden, E. Bell, A.S. Robinson, and F.J. Doyle III (2005) “Modeling the
`Unfolded Protein Response in Saccharomyces Cerevisiae”, Proc. Int. Conf. Foundations of
`Systems Biology, Santa Barbara, California. [not indexed]
`Griesemer, M., Young, C., Raden, D., Petzold, L., Robinson, A.S., Doyle, F.J. (2007)
`“Computational Modeling of Chaperone Interactions in the Endoplasmic Reticulum of
`Saccharomyces cerevisiae.” Proc. Int. Conf. Foundations of Systems Biology, Stuttgart,
`Germany.
`Yuraszeck, T., Raden, D, Robinson, A.S., and Doyle, F.J. (2007) “Microarray Analysis of the
`Unfolded Protein Response in S. cerevisiae Reveals Evidence of Down-regulation.” Proc. Int.
`Conf. Foundations of Systems Biology, Stuttgart, Germany.
`Yuraszeck, Theresa M., Pierre Neveu, Maria Rodriguez-Fernandez, Anne Robinson, Kenneth S.
`Kosik, Francis J. Doyle III (2009) Development of a mathematical model to investigate the
`pathophysiology of tau protein.” Proc. Int. Conf. Foundations of Systems Biology, Denver, CO.
`
`
`Professional Service (abbreviated list)
`National and local organization leadership
`2015-
`Board of Directors, AIChE
`2013-2015
`Board of Directors, CCR
`2010-
`Advisory Board Member, Northwestern University Department of Chemical and Biological
`Engineering
`Member, Advisory Committee for Pharmaceutical Sciences, Food and Drug Administration
`2006-
`2008-2011 ACS BIOT Division Awards Chair
`2010
`
`Advisory Board Member, UMBC Department of Chemical and Biological Engineering
`2009
`
`Co-Chair – Biochemical Engineering XVI
`2007-2009 Advisory Board, BioXXcel Educational Project (NSF DUE 0633373, PI: Komives; co-PIs:
`Fernandez, Beitle)
`2007
`
`Vice-Chair – Biochemical Engineering XV
`2006
`
`Chair – American Chemical Society BIOT Division
`2005
`
`Chair Elect – American Chemical Society BIOT Division
`2004
`Program Co-Chair – American Chemical Society BIOT Division
`
`
`7
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`Page 7
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