Application Number:
`
`Filing Date:
`
`13071105
`
`24-Mar-2011
`
`Title of Invention:
`
`Digital Amplification
`
`First Named Inventor/Applicant Name:
`
`Utility under 35 USC 111(a) Filing Fees
`
`Description
`
`Fee Code
`
`Quantity
`
`maven In
`
`Basic Filing:
`
`Electronic Patent Application Fee Transmittal
`
`Post-Allowance-and-Post-Issuance:
`
`Independentclaims in excess of 3
`
`1
`
`250
`
`Miscellaneous-Filing:
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`Petition:
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`Patent-Appeals-and-interference:
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`Page 374 of 1224
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`Description
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`Fee Code
`
`Quantity
`
`Amount
`
`Sub-Total in
`
`USD(S)
`
`Extension-of-Time:
`
`Miscellaneous:
`
`
`
`
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`Page 375 of 1224
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`
`
`Electronic Acknowledgement Receipt
`
`ee
`
`
`
`ec
`
`
`
`
`
`
`
`
`Digital Amplification
`
`Title of Invention:
`
`
`
`
`
`
`
`neas
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`»aa
`
`Application Type:
`
`Utility under 35 USC 111(a)
`
`Paymentinformation:
`
`
`Payment Type
`
`Deposit Account
`
`File Listing:
`
`Document
`
`5
`
`5
`
`7
`
`as
`
`.
`
`File Size(Bytes)/
`
`Multi
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`Pages
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`Page 376 of 1224
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`Preliminary Amendment
`
`001107prelimoosé6amd.pdf
`
`112622
`
`205049633ecde45742e71819abd86or74
`bdofs
`
`Fee Worksheet (SB06)
`
`fee-info.pdf
`
`c6b0eet754b1dBe29acIe2d130GH90Aceq
`fa060
`
`Information:
`
`Information:
`
`
`
`New International Application Filed with the USPTO as a Receiving Office
`Ifa new international applicationis beingfiled and the international application includes the necessary components for
`an internationalfiling date (see PCT Article 11 and MPEP 1810), a Notification of the International Application Number
`and of the International Filing Date (Form PCT/RO/105)will be issued in due course, subject to prescriptions concerning
`national security, and the date shown on this AcknowledgementReceiptwill establish the internationalfiling date of
`the application.
`
`This AcknowledgementReceipt evidences receipt on the noted date by the USPTOofthe indicated documents,
`characterized by the applicant, and including page counts, where applicable. It serves as evidence of receiptsimilar toa
`Post Card, as described in MPEP 503.
`
`New Applications Under 35 U.S.C. 111
`If a new applicationis being filed and the application includes the necessary componentsfora filing date (see 37 CFR
`1.53(b)-(d) and MPEP 506), a Filing Receipt (37 CFR 1.54)will be issued in due course and the date shown onthis
`AcknowledgementReceiptwill establish the filing date of the application.
`
`National Stage of an International Application under 35 U.S.C. 371
`If a timely submissionto enter the national stage of an international application is compliant with the conditions of 35
`U.S.C, 371 and other applicable requirements a Form PCT/DO/EO/903indicating acceptanceof the application asa
`national stage submission under35 U.S.C, 371 will be issued in addition to the Filing Receipt, in due course.
`
`Page 377 of 1224
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`

`PTO/SB/06 (07-06)
`Approvedfor use through 1/31/2007. OMB 0651-0032
`U.S, Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`persons are required to respondto a collection of information unlessit displays a valid OMB control number.
`Under the Paperwork Reduction Act of 1995, no
`
`
`
`
`| Application or Docket Number
`||
`“Filing Date
`~ PATENT APPLICATION FEE DETERMINATION RECORD
`
`
`13/071 ,105
`03/24/2011 || [1] tobe Matted
`Substitute for Form PTO-875
`
`
`OTHER THAN
`
`
`SMALL ENTITY
`
`
`j
`FOR
`
`{37 CFR 1.16(a),
`
`37 GER 1.16(%),
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`. Pf
`
`
`
`If the specification and drawings exceed 100
`
`
`
`sheets of paper, the application size fee due
`is $250 ($125 for small entity) for each
`additional 50 sheetsorfraction thereof. See
`
`
`
`
`35 U.S.C. 41(a)(1)(G) and 37 CFR 1.16(s).
`
`
`
`C] MULTIPLE DEPENDENT CLAIM PRESENT (37 CFR 1.16()))
`* If the difference in column ‘4 Is less than zero, enter“0” in column 2.
`
`
`
`
`
`(Column 2)
`(Column 1)
`HIGHEST
`— — CLAIMS
`ADDITIONAL
`ADDITIONAL
`PRESENT
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`REMAINING
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`11/30/2011|acter PREVIOUSLY EXTRA
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`AMENDMENT
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`[_] Application Size Fee (37 CFR 1.16(s))
`C FIRST PRESENTATION OF MULTIPLE DEPENDENTCLAIM (37 CFR 1.16()))
`
`minus 3 =
`(37 CFR1.16(s))
`
`
`
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`
`
`
`
`FEE($)
`AMENDMENT a
`
`
`
`
`
`
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`ADD'L
`FEE
`
`
`
`
`
` AMENDMENT Cl FIRST PRESENTATION OF MULTIPLE DEPENDENTCLAIM (37 GFR 1.16(j))
`
`
`
`
`APPLICATIONAS FILED — PART I
`(Column 1)
`NUMBERFILED
`(b), or (c)) ee NIA emer
`(i), or
`;
`.
`N/A — :
`
`-
`
`(Column 2)
`NUMBEA EXTRA
`N/A —
`NIA
`
`~
`
`
`
`;
`
`
`
`|
`
`ee 2
`(37 CER 1.16(i
`INDEPENDENT CLAIMS
`(37 CFR 1.16(h
`
`
`
`
`
`
`
`
`
`
`
`[APPLICATION SIZE FEE
`
`APPLICATION AS AMENDED— PART Il
`
`TOTAL
`
`
`
`TOTAL
`
`OTHER THAN
`SMALL ENTITY
`
`(Column 3)
`
`SMALL ENTITY
`
`OR
`
`|T
`= O
`
`R
`
`RATE(8)
`
`ADDITIONAL
`FEE($)
`
`
`
`(Column 1)
`(Column 2)
`CLAIMS
`HIGHEST
`REMAINING
`NUMBER
`
`AFTER
`PREVIOUSLY
`AMENDMENT
`PAID FOR
`Teeee
`co1 fs
`37 CFR 1.16:
`[__| Application Size Fee (37 CER 1.16(s))
`
`(Golumn3)
`
`ADDITIONAL
`FEE ($)
`
`.
`
`.
`
`.
`
`te
`
`"0" |
`
`
`.
`*
`
`
`withe"HhoatNunber PewseyPadForINTHISSPACEIs bee than2,enar-a0,
`VegaInstrument Examiner:
`
`
`20, enter
`“20”.
`/ELMIRA HALL’
`e
`“Highest
`NumberPreviously Paid
`Fo!
`is
`less
`than
`if the “Highest Number Previously Paid For" IN THIS SPACEis less than 3, enter “3”.
`
`
`f, The “Highest Number Previously Paid For” (Total or Independent)is the highest number found in the appropriate box in column 1.
`
`
`This collection of information is required by 37 GFR 1.16. Theinformation is required to obtain orretain a benalit by the public whichis to file (and by the USPTO to
`process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 GFR 1.14. This collection is estimated to take 12 minutes to complete,including gathering,
`preparing, and submitting the completed application form to the USPTO.Timewill vary depending uponthe individual case. Any comments on the amountof time you
`require to complete this form and/or suggestionsfor reducing this burden, should be sent to the Chief Information Officer, U.S. Patent and TrademarkOffice, U.S.
`Department of Commerce, P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMSTO THIS
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`ifyou need assistance in campleting the form, call 1-800-PTO-9199 and selectoption 2.
`
`Page 378 of 1224
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`
`
`APPLICATION NUMBER
`
`PATENT NUMBER
`
`——
`Unirep Stares PareNT AND TRADEMARK OFFICE
`UNITED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`Address: COMMISSIONER FOR PATENTS
`exandsia, Virginia 22313-1450
`Wwrwmuspto.gov
`.
`
`GROUP ART UNIT
`
`FILE WRAPPER LOCATION
`
`13/071,105
`
`1637
`
`nLUNL
`
`LOMA
`
`Correspondence Address/Fee Address Change
`
`The following fields have been set to Customer Number 11332 on 10/24/2011
`° Correspondence Address
`
`The address of record for Customer Number 11332 is:
`
`11332
`Banner & Witcoff, Ltd.
`Attorneys for client 001107
`1100 13th Street N.W.
`Suite 1200
`Washingion, DC 20005-4051
`
`PART 1 - ATTORNEY/APPLICANT COPY
`page 1 of 1
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`Page 379 of 1224
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`
`
`UNITED STATES PATENT AND ‘TRADEMARK OFFICE
`UNTTFED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`Address. COMMISSIONER FOR PATENTS
`Alexandeia, Vingnia 22313-1450
`WwW.ugptogov
`
`APPLICATION NUMBER
`
`FILING OR 371(C) DATE
`
`FIRST NAMED APPLICANT
`
`ATTY, DOCKET NO/TITLE
`
`13/071,105
`
`03/24/2011
`
`22907
`BANNER & WITCOFF, LTD.
`
`100foSTREET,
`
`WASHINGTON, DC 20005-4051
`
`Bert VOGELSTEIN
`
`001107.00866
`CONFIRMATION NO.3361
`PUBLICATION NOTICE
`
`neygg
`
`Title: Digital Amplification
`
`Publication No.US-201 1-0201004-A1
`Publication Date:08/18/2011
`
`NOTICE OF PUBLICATION OF APPLICATION
`
`The above-identified application will be electronically published as a patent application publication pursuant to 37
`CFR 1.211, et seq. The patent application publication number and publication date are set forth above.
`
`The publication may be accessed through the USPTO's publically available Searchable Databasesvia the
`Internet at www.uspto.gov. The direct link to access the publication is currently http:/Avww.uspto.gov/pattft/.
`
`The publication process established by the Office does not provide for mailing a copy of the publication to
`applicant. A copy of the publication may be obtained from the Office upon paymentof the appropriate fee set forth
`in 37 CFR 1.19(a)(1). Orders for copies of patent application publications are handled by the USPTO's Office of
`Public Records. The Office of Public Records can be reached by telephone at (703) 308-9726 or (800) 972-6382,
`by facsimile at (703) 305-8759, by mail addressed to the United States Patent and Trademark Office, Office of
`Public Records, Alexandria, VA 22313-1450orvia the Internet.
`
`In addition, information on the status of the application, including the mailing date of Office actions and the
`dates of receipt of correspondencefiled in the Office, may also be accessedvia the Internet through the Patent
`Electronic Business Center at www.uspto.gov using the public side of the Patent Application Information and
`Retrieval (PAIR) system. The direct link to accessthis status information is currently http://pair.uspto.gov/. Prior to
`publication, such status information is confidential and may only be obtained by applicant using the private side of
`PAIR.
`
`Further assistance in electronically accessing the publication, or about PAIR,is available by calling the Patent
`Electronic Business Center at 1-866-217-9197.
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`Office of Data Managment, Application Assistance Unit (571) 272-4000, or (571) 272-4200, or 1-888-786-0101
`
`page 1 of 1
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`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`UNITED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`OL
`x.
`Address: COMMISSIONER FOR PATENTS
`Alexanddia, Virginia 22333-1450
`wrrviuspto.gov
`
`|| GRPART | ee
` “APPLICATION| FILINGor
`
`UNIT
`FIL FEE REC'D
`371(c) DATE
`NUMBER
`ATTY.DOCKET.NO
`13/071,105 03/24/2011
`1634
`2986
`001107.00866
`48
`5
`CONFIRMATION NO.3361
`
`22907
`BANNER & WITCOFF, LTD.
`
`1ahSET. NW
`
`WASHINGTON, DC 20005-4051
`
`UPDATED FILING RECEIPT
`
`nH
`
`Date Mailed: 07/15/2011
`
`Receipt is acknowledgedofthis non-provisional patent application. The application will be taken up for examination
`in due course. Applicant will be notified as to the results of the examination. Any correspondence concerning the
`application mustinclude the following identification information: the U.S. APPLICATION NUMBER, FILING DATE,
`NAME OF APPLICANT, and TITLE OF INVENTION. Fees transmitted by check or draft are subjectto collection.
`Pleaseverify the accuracy of the data presentedonthis receipt. If an error is noted on this Filing Receipt, please
`submit a written requestfor a Filing Receipt Correction. Please provide a copyof this Filing Receipt with the
`changes noted thereon.If you recelved a "Notice to File Missing Parts" for this application, please submit
`any corrections to this Filing Recelpt with your reply to the Notice. When the USPTO processesthe reply
`to the Notice, the USPTO will generate another Fillng Recelpt Incorporating the requested corrections
`
`Applicant(s)
`
`Bert VOGELSTEIN, Baltimore, MD;
`Kenneth W. KINZLER, Baltimore, MD;
`Assignment For Published Patent Application
`THE JOHNS HOPKINS UNIVERSITY,Baltimore, MD
`
`Powerof Attorney:
`Dale Hoscheit--19090
`Joseph Skerpon--29864
`William Fisher--32133
`Sarah Kagan--32141
`Lisa Hemmendinger--42653
`
`Domestic Priority data as claimed by applicant
`This application is a CON of 12/617,368 11/12/2009 PAT 7,915,015
`which is a CON of 11/709,742 02/23/2007 PAT 7,824,889
`which is a CON of 10/828,295 04/21/2004 ABN
`whichis a DIV of 09/981,356 10/12/2001 PAT 6,753,147
`which is a CON of 09/613,826 07/11/2000 PAT6,440,706
`which claims benefit of 60/146,792 08/02/1999
`
`Foreign Applications (You maybeeligible to benefit from the Patent Prosecution Highway program at the
`USPTO. Please see http://www.uspto.gov for more information.)
`
`If Required, Foreign Filing License Granted: 04/19/2011
`
`page 1 of 3
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`
`
`The country code and numberof yourpriority application, to be usedforfiling abroad under the Paris Convention,
`is US 13/071,105
`
`Projected Publication Date: 08/18/2011
`
`Non-Publication Request: No
`
`Early Publication Request: No
`Title
`
`Digital Amplification
`
`Preliminary Class
`
`435
`
`PROTECTING YOUR INVENTION OUTSIDE THE UNITED STATES
`
`Since the rights granted by a U.S. patent extend only throughouttheterritory of the United States and have no
`effect in a foreign country, an inventor who wishes patent protection in another country must apply for a patent
`in a specific country or in regional patent offices. Applicants may wish to considerthe fillng of an international
`application under the Patent Cooperation Treaty (PCT). An international (PCT) application generally has the same
`effect as a regular national patent application in each PCT-member country. The PCT process simplifies thefiling
`of patent applications on the sameinvention in member countries, but does not result in a grant of “an international
`patent" and doesnoteliminate the need of applicantsto file additional documents and fees in countries where patent
`protection is desired.
`
`Almost every country has its own patent law, and a person desiring a patent in a particular country must make an
`application for patent in that country in accordancewith its particular laws. Since the laws of many countries differ
`in various respects from the patent law of the United States, applicants are advised to seek guidance from specific
`foreign countries to ensure that patent rights are not lost prematurely.
`
`Applicants also are advisedthatin the case of inventions madein the United States, the Director of the USPTO must
`issue a license before applicants can apply for a patent in a foreign country. Thefiling of a U.S. patent application
`serves as a requestfor a foreign filing license. The application's filing receipt contains further information and
`guidanceasto the status of applicant's licenseforforeignfiling.
`
`Applicants may wish to consult the USPTO booklet, "General Information Concerning Patents"(specifically, the
`section entitled "Treaties and Foreign Patents") for more information on timeframes and deadlinesforfiling foreign
`patent applications. The guideis available either by contacting the USPTO Contact Center at 800-786-9199,orit
`can be viewed on the USPTO website at http:/Avwww.uspto.gov/web/offices/pac/doc/general/index.html.
`
`For information on preventing theft of your intellectual property (patents, trademarks and copyrights), you may wish
`to consult the U.S. Government website, http://Awww.stopfakes.gov. Part of a Department of Commerceinitiative,
`this website includes self-help "toolkits" giving innovators guidance on howto protectintellectual property in specific
`countries such as China, Korea and Mexico. For questions regarding patent enforcement issues, applicants may
`call the U.S. Governmenthotline at 1-866-999-HALT (1-866-999-4158).
`
`page 2 of 3
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`

`

`LICENSE FOR FOREIGN FILING UNDER
`
`Title 35, United States Code, Section 184
`
`Title 37, Code of Federal Regulations, 5.11 & 5.15
`
`GRANTED
`
`The applicant has been granted a license under 35 U.S.C. 184, if the phrase "IF REQUIRED, FOREIGN FILING
`LICENSE GRANTED"followed by a date appears on this form. Such licenses are issued in all applications where
`the conditions for issuance of a license have been met, regardless of whether or not a license may be required as
`set forth in 37 CFR 5.15. The scope andlimitations ofthis license are set forth in 37 CFR 5.15(a) unless an earlier
`license has been issued under 37 CFR 5.15(b). The license is subject to revocation upon written notification. The
`dateindicated is the effective date of the license, unless an earlier license of similar scope has been granted under
`37 CFR 5.13 or 5.14.
`
`This licenseis to be retained by the licensee and may be usedat any time on or after the effective date thereof unless
`itis revoked. This license is automatically transferred to any related applications(s)filed under 37 CFR 1.53(d). This
`license is not retroactive.
`
`The grant of a license does not in any way lessen the responsibility of a licensee for the security of the subject matter
`as Imposed by any Governmentcontract or the provisions of existing laws relating to espionage and the national
`security or the exportof technical data. Licensees should apprise themselvesof current regulations especially with
`respect to certain countries, of other agencies, particularly the Office of Defense Trade Controls, Departmentof
`State (with respect to Arms, Munitions and Implements of War (22 CFR 121-128)); the Bureau of Industry and
`Security, Department of Commerce (15 CFR parts 730-774); the Office of Foreign AssetsControl, Departmentof
`Treasury (31 CFR Parts 500+) and the Department of Energy.
`
`NOT GRANTED
`
`No license under 35 U.S.C. 184 has been grantedatthis time, if the phrase "IF REQUIRED, FOREIGN FILING
`LICENSE GRANTED" DOESNOTappearonthis form. Applicant maystill petition for a license under 37 CFR 5.12,
`if a license is desired before the expiration of 6 months from thefiling date of the application. If 6 months has lapsed
`from thefiling date of this application and the licensee has not received any indication of a secrecy order under 35
`U.S.C. 181, the licensee mayforeign file the application pursuant to 37 CFR 5.15(b).
`
`
`
`
`page 3 of 3
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`

`

`INDEPENDENT CLAIMS
`
`(37 GFR 1.16(h))
`
`|_
`
`If the specification and drawings exceed 100
`REECICATION SIZE|sheets of paper, the application size fee dueIs
`$270 ($135 for small entity) for each additional
`(37 CFR 1.16(s))
`50 sheetsorfraction thereof. See 35 U.S.C.
`41(a)(1)(G) and 37 CFR 1.16(s).
`
`MULTIPLE DEPENDENT CLAIM PRESENT(37 CFR 1.16()))
`
`
`
`* lf the difference in column 1 is less than zero, enter "0" in column 2.
`
`APPLIGATION AS AMENDED- PARTIl
`
`
`{Golumn 1)
`(Column 2}
`CLAIMS
`HIGHEST
`REMAINING
`NUMBER
`AFTER
`PREVIOUSLY
`AMENDMENT
`PAID FOR
`
`(Column 3}
`PRESENT
`EXTRA
`
` AMENDMENTA
`
`Total
`(37 CFR 1.16()}
`Independent
`(37 CFA 1.16(h))
`Application Size Fee (37 CFR 1.16(s))
`
`|
`
`FIRST PRESENTATION OF MULTIPLE DEPENDENTCLAIM (37 CFR 1.16()))
`
`SMALL ENTITY
`
`OTHER THAN
`SMALL ENTITY
`
`ADDITIONAL
`
`
`
`
`
`x
`
`
`
`Application or Docket Number
`PATENT APPLICATION FEE DETERMINATION RECORD
`Substitute for Form PTO-875 43/071,105
`
`
`OTHER THAN
`APPLICATIONAS FILED - PART |
`
`
`
`SMALL ENTITY
`OR
`SMALL ENTITY
`(Column 1)
`(Column 2)
`
`
`
`
`FOR NUMBER FILED|NUMBER EXTRA RATE($) FEE(S)
`
`
`BASIC FEE
`
`
`SEARCH FEE
`
`
`SEARCHTeri N/ApNA|foNIA
`
`
`
`
`EXAMINATION FEE
`N/A
`N/A
`N/A
`
`(37 CFR 1.16(0), (p), or (q))
`TOTAL CLAIMS
`"
`7
`
`
`FEES)
`
`
`
`
`
`
`{Column 1}
`REMAINING
`AFTER
`
`(Column 2)
`
`NUMBER
`PREVIOUSLY
`PAID FOR
`
`{Column 3)
`
`PRESENT
`EXTRA
`
`(37 CFR 1.160)
`Independent
`(37 CFR 1.16(h))
`
`Minus
`
`= Total
`AMENDMENT DDITIONAL
`AMENDMENTB
`
`
`
`
`RATE($)
`
`ADDITION.
`
`x
`
`DDITIONAL
`Al PEER)
`
`ADD'L FEE
`* Ifthe entry in column 1 is less than the entry in column2, write "0" in column 3.
`* Ifthe "Highest Number Previously Paid For" IN THIS SPACEisless than 20, enter "20".
`*™ Ifthe "Highest Number Previously Paid For* IN THIS SPACEIs less than 3, enter "3".
`
`The "Highest Number Previously Paid Fort (Total or Independent) is the highest found in the appropriate box in column 1.
`
`Page 384 of 1224
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`

`UTILITY PATENT
`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`In re Applicationof:
`
`Group Art Unit: TBA
`
`Bert VOGELSTEIN etal.
`
`Docket No. 001107.00866
`
`Serial No. 13/071,105
`
`Filed: March 24, 2011
`
`For: DIGITAL AMPLIFICATION
`
`Confirmation No: 3361
`
`Examiner: TBA
`
`
`RESPONSE TO NOTICE TO FILEMISSING PARTS OF NONPROVISIONAL
`APPLICATION
`
`USS. Patent and Trademark Office
`Customer Service Window
`Randolph Building, Mail Stop: Missing Parts
`401 Dulany Street
`Alexandria, VA 22314
`
`DearSir:
`
`In response to the Notice to File Missing Parts of Non-provisional Application under 37
`
`C.F.R. §1.53(b), dated May 9, 2011, applicant submits the fees due. The fees are calculated as
`
`follows:
`
`2 Independentclaims over3
`
`28 total claims over 20
`
`Total Fees
`
`$440.00
`
`$1456.00
`
`$1896.00
`
`Page 385 of 1224
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`Bert VOGELSTEIN etal.
`U.S. Patent Application No. 13/071,105
`
`Webelieve that all Patent and Trademark Office requirements have now been fully met andit
`
`werespectfully request that the above-identified patent application be forwarded for examination.
`
`Please charge the filing of this paper and any additional fee, which may be associated to our
`
`Deposit Account No. 19-0733.
`
`Respectfully submitted,
`
`By:_/Sarah A, Kagan/
`Sarah A, Kagan
`Registration, No, 32,141
`
`Banner & Witcoff, Ltd.
`1100 13Street, N.W., Suite 1200
`Washington, D.C. 20005-4051
`(202) 824-3000
`
`Dated: July 8, 2011
`
`
`
`Page 386 of 1224
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`
`
`Electronic Patent Application Fee Transmittal
`
`Application Number:
`
`13071105
`
`24-Mar-2011
`
`Filing Date: Title of Invention:
`
`Digital Amplification
`
`First Named Inventor/Applicant Name:
`
`Bert VOGELSTEIN
`
`Sarah Anne Kagan./Daphne Cashion
`
`Attorney Docket Number:
`
`001107,00866
`
`Filed as Large Entity
`
`Utility under 35 USC 111(a) Filing Fees
`
`Basic Filing:
`
`Pages:
`
`Claims:
`
`Claims in excess of 20
`
`Independent claims in excess of 3
`
`1202
`
`1201
`
`2
`
`52
`
`20
`
`2
`
`1456
`
`440
`
`Miscellaneous-Filing:
`
`Patent-Appeals-and-Interference:
`
`Post-Allowance-and-Post-issuance:
`
`Page 387 of 1224
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`Page 387 of 1224
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`

`
`
`Description
`
`Fee Code
`
`Quantity
`
`Amount
`
`Sub-Total in
`
`USD(S)
`
`Extension-of-Time:
`
`Miscellaneous:
`
`Totalin USD ($)
`
`
`
`Page 388 of 1224
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`

`
`
`Electronic Acknowledgement Receipt
`
`Application Number:
`
`13071105
`
`International Application Number:
`
`Confirmation Number:
`
`3361
`
`Title of Invention:
`
`Digital Amplification
`
`
`
`ee
`
`I
`
`Application Type:
`
`Utility under 35 USC 111(a)
`
`Paymentinformation:
`
`Charge any Additional Fees required under 37 C.F.R. Section 1.21 (Miscellaneous fees and charges)
`
`Deposit Account
`
`190733
`
`The Director of the USPTO is hereby authorized to charge indicated fees and credit any overpaymentas follows:
`
`Page 389 of 1224
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`
`
`File Listing:
`
`Document
`
`.
`
`:
`
`File Size(Bytes)/
`
`Multi
`
`Pages
`
`Applicant Response to Pre-Exam
`Formalities Notice
`
`001107_00866_Response_to_N
`otice_to_File_Missing_Parts_07
`_08_2011.pdf
`
`66f3abdce50127e06f01e00%2632(03¢503
`0361
`
`Warnings:
`
`information:
`
`Information:
`
`Fee Worksheet (SB06)
`
`fee-info.pdf
`
`187(04b 1lad78B3t4eh0926tdd67d763cee]
`
`
`
`
`New International Application Filed with the USPTO as a Receiving Office
`if a new international application is being filed and the international application includes the necessary componentsfor
`an internationalfiling date (see PCT Article 11 and MPEP 1810), a Notification of the International Application Number
`andof the International Filing Date (Form PCT/RO/105)will be issued in due course, subject to prescriptions concerning
`national security, and the date shown on this AcknowledgementReceiptwill establish the internationalfiling date of
`the application.
`
`This AcknowledgementReceipt evidences receipt on the noted date by the USPTO of the indicated documents,
`characterized by the applicant, and including page counts, where applicable. It serves as evidence of receipt similar toa
`Post Card, as described in MPEP 503.
`
`New Applications Under 35 U.S.C. 111
`Ifa new application is being filed and the application includes the necessary components fora filing date (see 37 CFR
`1.53(b)-(d) and MPEP 506), a Filing Receipt (37 CFR 1.54)will be issued in due course and the date shown onthis
`AcknowledgementReceiptwill establish the filing date of the application.
`
`National Stage of an International Application under 35 U.S.C. 371
`Ifa timely submission to enter the national stage of an international application ls compliant with the conditions of 35
`U.S.C. 371 and other applicable requirements a Form PCT/DO/EO/903indicating acceptance of the application asa
`national stage submission under 35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`
`Page 390 of 1224
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`

`
`
`Unirep States PATENT AND TRADEMARK OFFIGE
`UNTTED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`20.
`x
`Address: COMMISSIONER FOR PATENTS
`Alexamdsia, Virginia 22313-1450
`Wwww.uspto.go¥
`
`GRP ART
`FILING or
`APPLICATION
`
`NUMBER
`371(¢) DATE
`UNIT
`FIL FEE RECD
`ATTY.DOCKET.NO
`{TOT CLAIMS|JIND CLAIMS
`1090
`48
`5
`13/071,105
`03/24/2011
`001107.00866
`CONFIRMATION NO. 3361
`
`BANNER & WITCOFF, LTD
`1100tahSTREET
`
`WASHINGTON, DC 20005-4051
`
`PILING RECET
`Ng.
`
`Date Mailed: 05/09/2011
`
`Receipt is acknowledged of this non-provisional patent application. The application will be taken up for examination
`in due course. Applicant will be notified as to the results of the examination. Any correspondence concerning the
`application must include the following identification information: the U.S. APPLICATION NUMBER, FILING DATE,
`NAME OF APPLICANT, and TITLE OF INVENTION. Fees transmitted by check or draft are subject:to collection.
`Pleaseverify the accuracy of the data presented on this receipt. If an error Is noted on this Filing Receipt, please
`submit a written requestfor a Filing Receipt Correction. Please provide a copyof this Filing Receipt with the
`changesnoted thereon.If you received a "Notice to File Missing Parts" for this application, please submit
`any corrections to this Filing Receipt with your reply to the Notice. When the USPTO processesthe reply
`to the Notice, the USPTO will generate another Fillng Recelpt Incorporating the requested corrections
`
`Applicant(s)
`
`Bert VOGELSTEIN, Baltimore, MD;
`Kenneth W. KINZLER, Baltimore, MD;
`Assignment For Published Patent Application
`THE JOHNS HOPKINS UNIVERSITY,Baltimore, MD
`
`Powerof Attorney:
`Dale Hoscheit--19090
`Joseph Skerpon--29864
`William Fisher--32 133
`Sarah Kagan--32141
`Lisa Hemmendinger--42653
`
`Domestic Priority data as claimed by applicant
`This application is a CON of 12/617,368 11/12/2009 PAT 7,915,015
`which is a CON of 11/709,742 02/23/2007 PAT 7,824,889
`which is a CONof 10/828,295 04/21/2004 ABN
`whichis a DIV of 09/981,356 10/12/2001 PAT6,753,147
`which is a CON of 09/613,826 07/11/2000 PAT 6,440,706
`which claims benefit of 60/146,792 08/02/1999
`
`Foreign Applications (You maybeeligible to benefit from the Patent Prosecution Highway program at the
`USPTO. Please see hito://(www.uspto.gov for more information.)
`
`If Required, Foreign [Filing License Granted: 04/19/2011
`
`page 1 of 3
`
`Page 391 of 1224
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`

`

`The country code and numberofyourpriority application, to be usedforfiling abroad under the Paris Convention,
`is US 13/071,105
`:
`
`Projected Publication Date: 08/18/2011
`
`Non-Publication Request: No
`
`Early Publication Request: No
`Title
`
`Digital Amplification
`
`Preliminary Class
`
`PROTECTING YOUR INVENTION OUTSIDE THE UNITED STATES
`
`Since the rights granted by a U.S. patent extend only throughoutthe territory of the United States and have no
`effect in a foreign country, an inventor who wishes patent protection in another country must apply for a patent
`in a specific country or in regional patent offices. Applicants may wish to considerthe filing of an international
`application under the Patent Cooperation Treaty (PCT). An International (PCT) application generally has. the same
`effect as a regular national patent application in each PCT-membercountry. The PCT process simplifies,thefiling
`of patent applications on the sameinvention in membercountries, but does not result in a grant of "an international
`patent” and doesnoteliminate the need of applicantsto file additional documents and fees in countries where patent
`protection Is desired.
`
`Almost every country has Its own patent law, and a person desiring a patentin a particular country must make an
`application for patent in that country in accordance with Its particular laws. Since the laws of many countries differ
`in various respects from the patent law of the United States, applicants are advised to seek guidance from specific
`foreign countries to ensure that patent rights are not lost prematurely.
`
`Applicants also are advisedthat in the case of inventions madein the United States, the Director of the USPTO must
`issue a license before applicants can apply for a patent in a foreign country. Thefiling of a U.S. patent application
`serves as a request for a foreignfiling license. The application's filing receipt contains further information and
`guidanceasto the status of applicant's license for foreignfiling.
`
`Applicants may wish to consult the USPTO booklet, "General Information Concerning Patents" (specifically, the
`section entitled "Treaties and Foreign Patents") for more information on timeframes and deadlinesforfiling foreign
`patent applications. The guide is available either by contacting the USPTO Contact Center at 800-786-9199,orit
`can be viewed on the USPTO website at http:/Avww.uspto.gov/web/offices/pac/doc/general/index.html.
`
`For information on preventing theft of your intellectual property (patents, trademarks and copyrights), you may wish
`to consult the U.S. Government website, http:/Avww.stopfakes.gov. Part of a Department of Commerceinitiative,
`this website includes self-help "toolkits" giving innovators guidance on howto protectintellectual property in specific
`countries such as China, Korea and Mexico. For questions regarding patent enforcementissues, applicants may
`call the U.S. Governmenthotline at 1-866-999-HALT (1-866-999-4158).
`
`
`
`page 2 of 3
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`Page 392 of 1224
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`

`LICENSE FOR FOREIGN FILING UNDER
`
`Title 35, United States Code, Section 184
`
`Title 37, Code of Federal Regulations, 5.11 & 5.15
`
`GRANTED
`
`The applicant has been granted a license under 35 U.S.C. 184, if the phrase "IF REQUIRED, FOREIGN FILING
`LICENSE GRANTED"followed by a date appears onthis form. Such licenses are issued in all applications where
`the conditions for issuance of a license have been met, regardless of whetheror not a license may be required as
`set forth in 37 CFR 5.15. The scope andlimitations of this license are set forth in37 CFR 5.15(a) unless an earlier
`license has been issued under 37 CFR 5,15(b). The license is subject to revocation upon written notification. The
`date indicatedis the effective date of the license, unless an earlier license of similar scope has been granted under
`37 GFR 5.13 or 5.14.
`
`This licenseis to be retained by the licensee and may be used at any time onor after the effective date thereof unless
`itis revoked. This license is automatically transferred to any related applications(s)filed'under 37 CFR 1.53(d). This
`license is not retroactive.
`
`The grant of a license doesnotin any waylessen the responsibility of a licensee for the security of the subject matter
`as imposed by any Governmentcontract or the provisions of existing laws relating to espionage and the national
`security or the export of technical data. Licensees should apprise themselvesof current regulations especially with
`respect to certain countries, of other agencies, particularly the Office of Defense Trade Controls, Department of
`State (with respect to Arms, Munitions and Implements of War (22 CFR 121-128)); the Bureau of Industry and
`Security, Department of Commerce (15 CFR parts 730-774); the Office of Foreign AssetsControl, Departmentof
`Treasury (31 CFR Parts 500+) and the Departmentof Energy.
`
`NOT GRANTED
`
`No license under 35 U.S.C. 184 has been granted atthis time,if the phrase "IF REQUIRED, FOREIGN FILING
`LICENSE GRANTED" DOES NOTappearonthis form. Applicant maystill petition for a license under 37 CFR 5.12,
`if a license is desired before the expiration of 6 monthsfrom thefiling date of the application. If 6 months has lapsed
`from thefiling date of this application and the licensee has not received any indication of a secrecy order under 35
`U.S.C. 181, the licensee mayforeign file the application pursuant to 37 CFR 5.15(b).
`
`
`
`page 3 of 3
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`Page 393 of 1224
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`

`
`
`UniTED States PATENT AND ‘TRADEMARK OFFIGE
`UNITED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`x 1450
`Address: COMMISSIONER FOR PATENTS
`Alexandcia, Virginia 22313-1450
`Whew.uspto.gov
`
`APPLICATION NUMBER
`13/071,105
`
`FILING OR 371(C) DATE
`03/24/2011’
`
`FIRST NAMED APPLICANT
`Bert VOGELSTEIN
`
`ATTY, DOCKET NOJ/TITLE
`001107.00866
`CONFIRMATION NO.3361
`
`22907
`BANNER& WITCOFF,LTD.
`
`100faSTREET,
`
`WASHINGTON, DC 20005-4051
`
`FORMALITIES LETTER
`
`Igg
`
`Date Mailed: 05/09/2011
`
`NOTICE TO FILE MISSING PARTS OF NONPROVISIONAL APPLICATION
`
`FILED UNDER 37 CFR 1.53(b)
`
`Filing Date Granted
`
`Items Required To Avoid Abandonment:
`
`An application numberandfiling date have bee