2/8/2018 What does an emerging technology pioneer in medtech look like?
`
`wicNU SLAFCH
`- Health and In1ouch . ) detection via fithess
`Health ' trackers
`
`HEALTHIT
`
`11 health companies make the World Economic
`Group tech pioneer list
`
`By STEPHANIE BAUM
`
`@ Post a comment/ Aug 28, 2013 at 8:46 AM
`
`54
`
`SHARES
`
`Nearly one-third of the 36 emerging technology pioneers chosen by the World
`Economic Forum this year have implications for the life sciences and health IT
`space. They represent robotics, noninvasive prenatal testing, using edible
`
`identifiers to guard against counterfeit drugs and an anti-smoking vaccine.
`
`Since 2000, the World Economic Forum has identified companies based on their
`potential to make a global impact with the groundbreaking technology they’ve
`
`developed. Here are 11 of the companies.
`
`Metabolic enzymes: Agios Pharmaceuticals has determined that some cancer
`cells need to feed an enzyme addiction. So if you can figure out a way to block the
`enzyme you can Kill the cancer’s nutrient supply and avoid affecting the other
`cells. It sees opportunity for up to 100 metabolic enzymes on which various
`cancers depend for nutrients but is developing treatments for eight. It’s also
`looking at genetic diseases that prevent the body from being able to produce a
`specific enzyme from birth — “inborn errors of metabolism.” Most show up in
`early childhood, and have with no treatment. They can be fatal or severely
`
`compromise quality of life.
`
`Harnessing nanotechnology: BIND Therapeutics has developed a drug
`delivery system using nanoparticles to transport therapeutics to fight cancer
`
`without weakening the rest of the body with the toxic treatments. Its lead product
`FOUNDATION EXHIBIT 2040
`
`GUARDANT V. FOUNDATION,,
`IPR 2017-01170
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`
`
`
`
`
`
`
`2/8/2018
`
`What does an emerging technology pioneer in medtech look like?
`
`Advertisement A nonprofit medical device
`
`developer: D-Rev: Design
`Revolution’s client base includes people in developing countries. The company
`develops medical devices such as prosthetic knees made with injection molded
`plastic at one-tenth of the cost of, say, a titanium equivalent. Although it does not
`donate its products it sells them for a few dollars apiece. It uses grants for
`research and development. It’s also developing a mass-produced version of the
`plastic knee along with other products. Given the current debate over medical
`costs, the company could make an interesting contribution on potential ways to
`
`reduce costs without jeopardizing patient safety.
`
`Gene therapy — a lesson from HIV: bluebird Bio has developed an
`innovative approach to gene therapy to treat genetic disorders such as childhood
`cerebral adrenoleukodystrophy, a rare and often fatal neurological disorder
`affecting young boys; and beta-thalassemia major and severe sickle cell disease.
`Its treatment approach is inspired by HIV, a lentivirus which can deposit viral
`RNA into the DNA of the host cell. Its technology involves transferring functional
`genes into the patient’s stem cells, which can transform into several different
`types of cells. It’s also collaborating with Celgene and Baylor University to modify
`
`patient’s T cells — a type of white blood cell — to combat cancer.
`
`Noninvasive prenatal testing: Natera appears to have surmounted the
`problem of how to perform prenatal tests to identify chromosomal abnormalities
`accurately and reduce the risk posed to the mother and their unborn child. Its
`Panorama blood test analyses the mother’s blood, which contains fragments of
`free-floating foetal DNA. Its accuracy claims to be comparable to amniocentesis
`and chorionic villus sampling. It uses data from the Human Genome Project to
`calculate the statistical probability that the sample represents a chromosomal
`disorder. The company also offers counseling to help clinicians and parents
`
`interpret the test results.
`
`Personalized cancer treatmment: Foundation Medicine launched a diagnostic
`
`test in June last year that can assess the best course of treatment across 236
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/ 2/9
`
`
`
`
`
`
`
`
`2/8/2018
`
`What does an emerging technology pioneer in medtech look like?
`
`therapies in the pipeline. Although Foundation has focused on solid tumors, a
`diagnostic test to assess treatment options for blood-based cancers is under
`
`development and expected to reach the market next year.
`
`Crowdsourced answers to big data questions: If you or your company have
`big data questions, Kaggle has a way of generating big data answers through a
`global pool of 100,000 data experts. According to a description of the
`
`company, businesses can either offer cash prizes to members of Kaggle’s
`community who can improve on their existing formulas to extract more value
`from their data sets. A couple of Big Pharma companies — Merck and Boehringer
`Ingelheim — have tapped their resources to get answers to predictive analytics
`questions, such as gauging demand for particular drugs across a wide geographic
`
`base. Participation can also be restricted when data is sensitive.
`
`Restoring vision: Second Sight Medical Products has developed a way to help
`partially restore vision to some patients with retinal degeneration. The procedure
`involves inserting its implant into the retina. The patient wears glasses that
`
`contain a camera. A small computer, on a belt, processes signals from the camera,
`
`and an antenna on the side of the glasses transmits them wirelessly to the implant.
`
`The implant sends electrical impulses to the brain, causing the patient to perceive
`patterns of light. Recipients have been able to follow sidewalks and identify
`doorways and read large print text. It is being developed further with the hope of
`improving the range of abilities restored to users and creating a similar solution
`
`for macular degeneration.
`
`A vaccine for nicotine addiction: A biotechnology company Selecta
`Biosciences is using synthetic nanoparticles to improve the immune system’s
`response. A vaccine against nicotine addiction is the company’s lead product and
`is in the midst of clinical trials. The idea is that by inducing antibodies to trap
`nicotine before it can trigger addiction, it can eliminate cravings. It’s also in the
`early stages of other applications including malaria and cancer. But it sees scope
`for additional areas such as allergies and autoimmune diseases such as type 1
`diabetes.
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`3/9
`
`
`
`
`
`
`
`
`2/8/2018
`
`What does an emerging technology pioneer in medtech look like?
`
`similar to humans, in three areas — force, vibration and temperature. The
`
`company also sees scope for surgical applications as well as other areas.
`
`Spotting counterfeits: Counterfeit drugs are a growing concern in the
`healthcare industry. Although there are parts of the U.S. where this has been a
`problem, such as Florida, it is an ongoing issue for developing countries.
`Pharmaceutical companies that want to protect their brand and the patient
`population that uses their medication are working with businesses like TrueTag
`Technologies to make it easier to separate legitimate and fake versions of their
`products. The identifiers, which can be scanned with a handheld device, are made
`of silica and embedded in pills. The substance has been approved by the FDA and
`is safe to eat. Nanotechnology is used to embed a unique code, similar to a bar
`code, into a tag that is smaller than the width of a human hair. These codes are
`linked to a database that adds a time-related dimension of encryption, making the
`tags practically impossible to counterfeit, according to a description of the
`
`technology.
`
`[Photo credit: the concept of education from BigStock Photos]
`
`MedCity Join us for MedCity INVEST May 1-2, 2018, the premier
`
`‘ b national healthcare investing conference. INVEST
`\ , unites over 300 active investors with corporate
`MAY 1-2, 2018 *« CHICAGO business development executives to facilitate
`
`National Healthcare Investing Event jyestment opportunities with the most promising
`
`healthcare startups. Register now »
`
`4 y f G+ in =
`
`SHARES
`
`TOPICS
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`4/9
`
`
`
`
`
`
`
`
`2/8/2018
`
`What does an emerging technology pioneer in medtech look like?
`
`—ADVERTISEMENT—
`
`Your email address
`
`WE RECOMMEND
`
`What does an emerging technology pioneer
`in medtech look like?
`
`MedCity News
`
`8 technologies that will transform healthcare
`in 2017 and beyond
`
`MedCity News
`
`CertiRx goes into medications to show how
`to spot counterfeit drugs
`MedCity News
`
`Big data meets genomic profiling to improve
`clinical trials for cancer drugs - MedCity
`News
`
`MedCity News
`
`Top 5 digital health deals in July offer insight
`into hot investment targets
`MedCity News
`
`Drug shortage buster: Mustard Tree aims
`to knock out shortages at the root
`MedCity News
`
`Chanel? Vuitton? Avastin?
`
`GenomeWeb
`
`Genetic Testing Firms Tout Underlying
`Bioinformatics Capabilities as Key
`Business Component
`
`GenomeWeb
`
`Ortho Adopts Startup Culture with Intense
`Dx Focus After Spin Off from J&J
`
`360Dx
`
`Sepsis Diagnostics Year in Review: A
`Highly Competitive Market Emerges
`360Dx
`
`Powered by
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/ 5/9
`
`
`
`
`
`
`
`
`2/8/2018 What does an emerging technology pioneer in medtech look like?
`
`) Recommend 2 Share
`
`' Start the discussion...
`i
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`Be the first to comment.
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`Sort by Best
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`[<] GOT NEWS? SEND US ATIP
`
`MedCity
`
`INVEST
`
`MAY 1-2, 2018 - CHICAGO
`National Healthcare Investing Event
`
`Join Us at MedCity INVEST 2018
`
`MedCity INVEST is the premier national healthcare investing conference based in the Midwest,
`uniting active investors with corporate business development executives to facilitate investment
`opportunities with the most promising healthcare startups. MedCity INVEST will be held May
`
`1-2, 2018 at the Four Seasons, Chicago. Register Now >>
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`
`
`
`
`
`
`
`2/8/2018 What does an emerging technology pioneer in medtech look like?
`
`financial future
`
`Learn how from experts and
`get your pressing questions answered
`
`CrthoNOW
`
`We keep you moving.
`
`PROMOTED
`Orthopedic Urgent Care Franchising is THE Opportunity of 2018
`
`With approximately 9,000 urgent care centers in the United States offering generalized care,
`OrthoNOW is the only franchised care center of its kind in the United States — a unique
`position to gain market share in this highly fragmented industry.
`
`CHRISTINE DURA
`
`MEDCITY >> INBOX
`
`Get the latest industry news first when you subscribe to our daily newsletter.
`
`Your email address
`
`Subscribe
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`7/9
`
`
`
`
`
`
`
`
`2/8/2018 What does an emerging technology pioneer in medtech look like?
`
`B ESSENTIALNUTRIENTS
`
`PROMOTED
`
`New study: frequent use of multivitamin/multimineral
`supplements reduces nutrient shortfalls and deficiencies
`
`Up to 9 in 10 Americans fall short in getting required amounts of one or more key nutrients
`from food alone
`
`CAMPAIGN FOR ESSENTIAL NUTRIENTS
`
`OUR SITES
`
`ABOVE
`THE L AW
`
`ABOVE THE LAW BREAKING
`ER IANE
`REDLINE DEFENSE
`
`BREAKING
`
`DEALBREAKER FASHIONISTA
`MedCity News
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`HOW
`APPEALING
`
`
`
`
`
`
`
`
`
`2/8/2018 What does an emerging technology pioneer in medtech look like?
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/ 9/9
`
`
`
`
`
`
`
`
`
`
`wicNU SLAFCH
`- Health and In1ouch . ) detection via fithess
`Health ' trackers
`
`HEALTHIT
`
`11 health companies make the World Economic
`Group tech pioneer list
`
`By STEPHANIE BAUM
`
`@ Post a comment/ Aug 28, 2013 at 8:46 AM
`
`54
`
`SHARES
`
`Nearly one-third of the 36 emerging technology pioneers chosen by the World
`Economic Forum this year have implications for the life sciences and health IT
`space. They represent robotics, noninvasive prenatal testing, using edible
`
`identifiers to guard against counterfeit drugs and an anti-smoking vaccine.
`
`Since 2000, the World Economic Forum has identified companies based on their
`potential to make a global impact with the groundbreaking technology they’ve
`
`developed. Here are 11 of the companies.
`
`Metabolic enzymes: Agios Pharmaceuticals has determined that some cancer
`cells need to feed an enzyme addiction. So if you can figure out a way to block the
`enzyme you can Kill the cancer’s nutrient supply and avoid affecting the other
`cells. It sees opportunity for up to 100 metabolic enzymes on which various
`cancers depend for nutrients but is developing treatments for eight. It’s also
`looking at genetic diseases that prevent the body from being able to produce a
`specific enzyme from birth — “inborn errors of metabolism.” Most show up in
`early childhood, and have with no treatment. They can be fatal or severely
`
`compromise quality of life.
`
`Harnessing nanotechnology: BIND Therapeutics has developed a drug
`delivery system using nanoparticles to transport therapeutics to fight cancer
`
`without weakening the rest of the body with the toxic treatments. Its lead product
`FOUNDATION EXHIBIT 2040
`
`GUARDANT V. FOUNDATION,,
`IPR 2017-01170
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`
`
`
`
`
`
`
`2/8/2018
`
`What does an emerging technology pioneer in medtech look like?
`
`Advertisement A nonprofit medical device
`
`developer: D-Rev: Design
`Revolution’s client base includes people in developing countries. The company
`develops medical devices such as prosthetic knees made with injection molded
`plastic at one-tenth of the cost of, say, a titanium equivalent. Although it does not
`donate its products it sells them for a few dollars apiece. It uses grants for
`research and development. It’s also developing a mass-produced version of the
`plastic knee along with other products. Given the current debate over medical
`costs, the company could make an interesting contribution on potential ways to
`
`reduce costs without jeopardizing patient safety.
`
`Gene therapy — a lesson from HIV: bluebird Bio has developed an
`innovative approach to gene therapy to treat genetic disorders such as childhood
`cerebral adrenoleukodystrophy, a rare and often fatal neurological disorder
`affecting young boys; and beta-thalassemia major and severe sickle cell disease.
`Its treatment approach is inspired by HIV, a lentivirus which can deposit viral
`RNA into the DNA of the host cell. Its technology involves transferring functional
`genes into the patient’s stem cells, which can transform into several different
`types of cells. It’s also collaborating with Celgene and Baylor University to modify
`
`patient’s T cells — a type of white blood cell — to combat cancer.
`
`Noninvasive prenatal testing: Natera appears to have surmounted the
`problem of how to perform prenatal tests to identify chromosomal abnormalities
`accurately and reduce the risk posed to the mother and their unborn child. Its
`Panorama blood test analyses the mother’s blood, which contains fragments of
`free-floating foetal DNA. Its accuracy claims to be comparable to amniocentesis
`and chorionic villus sampling. It uses data from the Human Genome Project to
`calculate the statistical probability that the sample represents a chromosomal
`disorder. The company also offers counseling to help clinicians and parents
`
`interpret the test results.
`
`Personalized cancer treatmment: Foundation Medicine launched a diagnostic
`
`test in June last year that can assess the best course of treatment across 236
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/ 2/9
`
`
`
`
`
`
`
`
`2/8/2018
`
`What does an emerging technology pioneer in medtech look like?
`
`therapies in the pipeline. Although Foundation has focused on solid tumors, a
`diagnostic test to assess treatment options for blood-based cancers is under
`
`development and expected to reach the market next year.
`
`Crowdsourced answers to big data questions: If you or your company have
`big data questions, Kaggle has a way of generating big data answers through a
`global pool of 100,000 data experts. According to a description of the
`
`company, businesses can either offer cash prizes to members of Kaggle’s
`community who can improve on their existing formulas to extract more value
`from their data sets. A couple of Big Pharma companies — Merck and Boehringer
`Ingelheim — have tapped their resources to get answers to predictive analytics
`questions, such as gauging demand for particular drugs across a wide geographic
`
`base. Participation can also be restricted when data is sensitive.
`
`Restoring vision: Second Sight Medical Products has developed a way to help
`partially restore vision to some patients with retinal degeneration. The procedure
`involves inserting its implant into the retina. The patient wears glasses that
`
`contain a camera. A small computer, on a belt, processes signals from the camera,
`
`and an antenna on the side of the glasses transmits them wirelessly to the implant.
`
`The implant sends electrical impulses to the brain, causing the patient to perceive
`patterns of light. Recipients have been able to follow sidewalks and identify
`doorways and read large print text. It is being developed further with the hope of
`improving the range of abilities restored to users and creating a similar solution
`
`for macular degeneration.
`
`A vaccine for nicotine addiction: A biotechnology company Selecta
`Biosciences is using synthetic nanoparticles to improve the immune system’s
`response. A vaccine against nicotine addiction is the company’s lead product and
`is in the midst of clinical trials. The idea is that by inducing antibodies to trap
`nicotine before it can trigger addiction, it can eliminate cravings. It’s also in the
`early stages of other applications including malaria and cancer. But it sees scope
`for additional areas such as allergies and autoimmune diseases such as type 1
`diabetes.
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`3/9
`
`
`
`
`
`
`
`
`2/8/2018
`
`What does an emerging technology pioneer in medtech look like?
`
`similar to humans, in three areas — force, vibration and temperature. The
`
`company also sees scope for surgical applications as well as other areas.
`
`Spotting counterfeits: Counterfeit drugs are a growing concern in the
`healthcare industry. Although there are parts of the U.S. where this has been a
`problem, such as Florida, it is an ongoing issue for developing countries.
`Pharmaceutical companies that want to protect their brand and the patient
`population that uses their medication are working with businesses like TrueTag
`Technologies to make it easier to separate legitimate and fake versions of their
`products. The identifiers, which can be scanned with a handheld device, are made
`of silica and embedded in pills. The substance has been approved by the FDA and
`is safe to eat. Nanotechnology is used to embed a unique code, similar to a bar
`code, into a tag that is smaller than the width of a human hair. These codes are
`linked to a database that adds a time-related dimension of encryption, making the
`tags practically impossible to counterfeit, according to a description of the
`
`technology.
`
`[Photo credit: the concept of education from BigStock Photos]
`
`MedCity Join us for MedCity INVEST May 1-2, 2018, the premier
`
`‘ b national healthcare investing conference. INVEST
`\ , unites over 300 active investors with corporate
`MAY 1-2, 2018 *« CHICAGO business development executives to facilitate
`
`National Healthcare Investing Event jyestment opportunities with the most promising
`
`healthcare startups. Register now »
`
`4 y f G+ in =
`
`SHARES
`
`TOPICS
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`4/9
`
`
`
`
`
`
`
`
`2/8/2018
`
`What does an emerging technology pioneer in medtech look like?
`
`—ADVERTISEMENT—
`
`Your email address
`
`WE RECOMMEND
`
`What does an emerging technology pioneer
`in medtech look like?
`
`MedCity News
`
`8 technologies that will transform healthcare
`in 2017 and beyond
`
`MedCity News
`
`CertiRx goes into medications to show how
`to spot counterfeit drugs
`MedCity News
`
`Big data meets genomic profiling to improve
`clinical trials for cancer drugs - MedCity
`News
`
`MedCity News
`
`Top 5 digital health deals in July offer insight
`into hot investment targets
`MedCity News
`
`Drug shortage buster: Mustard Tree aims
`to knock out shortages at the root
`MedCity News
`
`Chanel? Vuitton? Avastin?
`
`GenomeWeb
`
`Genetic Testing Firms Tout Underlying
`Bioinformatics Capabilities as Key
`Business Component
`
`GenomeWeb
`
`Ortho Adopts Startup Culture with Intense
`Dx Focus After Spin Off from J&J
`
`360Dx
`
`Sepsis Diagnostics Year in Review: A
`Highly Competitive Market Emerges
`360Dx
`
`Powered by
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/ 5/9
`
`
`
`
`
`
`
`
`2/8/2018 What does an emerging technology pioneer in medtech look like?
`
`) Recommend 2 Share
`
`' Start the discussion...
`i
`
`LOG IN WITH OR SIGN UP WITH Disaus (2)
`
`Name
`
`Be the first to comment.
`
`B4 subscribe ) Add Disqus to your siteAdd DisqusAdd @ Privacy
`
`Sort by Best
`
`[<] GOT NEWS? SEND US ATIP
`
`MedCity
`
`INVEST
`
`MAY 1-2, 2018 - CHICAGO
`National Healthcare Investing Event
`
`Join Us at MedCity INVEST 2018
`
`MedCity INVEST is the premier national healthcare investing conference based in the Midwest,
`uniting active investors with corporate business development executives to facilitate investment
`opportunities with the most promising healthcare startups. MedCity INVEST will be held May
`
`1-2, 2018 at the Four Seasons, Chicago. Register Now >>
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`
`
`
`
`
`
`
`2/8/2018 What does an emerging technology pioneer in medtech look like?
`
`financial future
`
`Learn how from experts and
`get your pressing questions answered
`
`CrthoNOW
`
`We keep you moving.
`
`PROMOTED
`Orthopedic Urgent Care Franchising is THE Opportunity of 2018
`
`With approximately 9,000 urgent care centers in the United States offering generalized care,
`OrthoNOW is the only franchised care center of its kind in the United States — a unique
`position to gain market share in this highly fragmented industry.
`
`CHRISTINE DURA
`
`MEDCITY >> INBOX
`
`Get the latest industry news first when you subscribe to our daily newsletter.
`
`Your email address
`
`Subscribe
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`7/9
`
`
`
`
`
`
`
`
`2/8/2018 What does an emerging technology pioneer in medtech look like?
`
`B ESSENTIALNUTRIENTS
`
`PROMOTED
`
`New study: frequent use of multivitamin/multimineral
`supplements reduces nutrient shortfalls and deficiencies
`
`Up to 9 in 10 Americans fall short in getting required amounts of one or more key nutrients
`from food alone
`
`CAMPAIGN FOR ESSENTIAL NUTRIENTS
`
`OUR SITES
`
`ABOVE
`THE L AW
`
`ABOVE THE LAW BREAKING
`ER IANE
`REDLINE DEFENSE
`
`BREAKING
`
`DEALBREAKER FASHIONISTA
`MedCity News
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/
`
`HOW
`APPEALING
`
`
`
`
`
`
`
`
`
`2/8/2018 What does an emerging technology pioneer in medtech look like?
`
`https://medcitynews.com/2013/08/what-does-a-technology-pioneer-in-medtech-look-1 ke-here-are-11/ 9/9
`
`
`
`
`
`
`
`
`
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