`B Vogelstein, KW Kinzler - Proceedings of the National …, 1999 - National Acad Sciences
`Abstract The identification of predefined mutations expected to be present in a minor fraction
`of a cell population is important for a variety of basic research and clinical applications.
`Here, we describe an approach for transforming the exponential, analog nature of the PCR
`into a linear, digital signal suitable for this purpose. Single molecules are isolated by dilution
`and individually amplified by PCR; each product is then analyzed separately for the …
`Cited by 1111 Related articles All 31 versions
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`The Johns Hopkins University Exhibit JHU2006 - Page 1 of 1
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