CURRICULUM VITAE
`
`POSITION TITLE
`Professor and Vice Chair
`Department of Bioengineering
`Professor of Mechanical Engineering
`Director, Cancer Nanotechnology Program
`Jonsson Comprehensive Cancer Center
`University of California, Los Angeles
`
`INSTITUTION AND LOCATION
`
`TRAINING MENTOR
`
`SCIENTIFIC
`DISCIPLINE
`
`Center for
`Engineering in
`Medicine
`
`Harvard Medical School,
`Massachusetts General Hospital
`
`University of California, Berkeley
`and San Francisco
`University of California, Berkeley
`
`Professor Mehmet Toner
`
`Professor Luke P. Lee
`
`Bioengineering
`
`Bioengineering
`
`NAME
`Dino Di Carlo
`
`
`
`EDUCATION & TRAINING:
`
`START
`MONTH/
`YEAR
`
`END
`MONTH
`/YEAR
`
`DEGREE (if
`applicable)
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`8/06
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`7/08
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`Post Doc
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`9/02
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`9/99
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`5/06
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`5/02
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`Ph. D.
`
`B. S.
`
`PROFESSIONAL POSITIONS:
`
`START
`MONTH/
`YEAR
`7/16
`6/16
`6/16
`7/15
`7/12
`7/08
`
`END
`MONTH
`/YEAR
`present
`present
`present
`present
`7/15
`7/12
`
`ACADEMIC
`
`POSITION TITLE
`
`DEPARTMENT
`
`INSTITUTION AND LOCATION
`
`Vice Chair
`Visiting Professor
`Professor
`Professor
`Associate Professor
`Assistant Professor
`
`Bioengineering
`Chemistry
`Mechanical Engineering
`Bioengineering
`Bioengineering
`Bioengineering
`
`University of California, Los Angeles
`University of Tokyo
`University of California, Los Angeles
`University of California, Los Angeles
`University of California, Los Angeles
`University of California, Los Angeles
`
`Awards and Honors
`2016 Presidential Early Career Award for Scientists and Engineers (PECASE)
`2016 Elected Fellow of the American Institute for Medical and Biological Engineering (AIMBE)
`2016 Materials Research Society Outstanding Young Investigator Award
`2015 Pioneers of Miniaturization Prize
`2015 Elected Fellow of the Royal Society of Chemistry (FRSC)
`2014 Analytical Chemistry Young Innovator Award
`2012 National Science Foundation (NSF) CAREER Award
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`ABS Global, Inc. and Genus plc – Ex. 1004, p. 1
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`

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`2012 Office of Naval Research (ONR) Young Investigator Award
`2011 David and Lucile Packard Fellowship in Science and Engineering
`2011 Defense Advanced Research Projects Agency (DARPA) Young Faculty Award
`2010 National Institutes of Health (NIH) Director’s New Innovator Award
`2010 Wallace H. Coulter Foundation Translational Research Award
`2005 Best Poster Award – Micro Total Analysis Systems Conference, Boston MA, USA
`2001 University of California Berkeley Bioengineering Departmental Citation (One award given annually)
`2000 Guidant Corporation Summer Research Award
`2000 Edward Frank Kraft Prize
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`
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`Fellowships
`American Cancer Society Postdoctoral Fellowship
`2007- 2009
`2002- 2006 Whitaker Foundation Graduate Fellowship
`2002- 2003 MESA Fellow, Sandia National Laboratories
`
`CONSULTING AND POSITIONS
`01/15 – present
`Co-Founder and Scientific Advisor
`03/15 – present
`Scientific Advisor
`
`
`
`
`11/14 – present
`Co-Founder and Board Member
`03/13 – present
`Co-Founder and Board Member
`01/13 – present
`Co-Founder and Board Member
`01/13 – present
`Consultant
`
`
`
`
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`12/15 – present
`Director
`
`
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`
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`09/12 – present Member
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`09/09 – present Member
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`08/09 – present
`Scientific Advisor
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`
`EDITORIAL / REFEREE ACTIVITY
`Editorial Board, Lab on a Chip, ACS Sensors, Associate Editor, SLAS Technology
`Journal Review: Advanced Materials, Nature Reviews Cellular and Molecular Biology, Nature, ACS Nano, ACS Chemical
`Biology, Lab on a Chip, Proceedings of the National Academy of Sciences of the USA, Nature Medicine, Journal of
`Laboratory Automation, Nature Nanotechnology, Nature Chemistry, Biomaterials, Nature Communications, Nature
`Methods, Rheologica Acta, Biotechnology and Bioengineering, Scientific Reports, PLoS One, FEMS Letters,
`Electrophoresis, Journal of Biomechanics, Journal of Fluid Mechanics, Cellular and Molecular Life Sciences, Journal of
`Physical Chemistry Letters, Physics of Fluids, Biomicrofluidics, Chemical Communications, Soft Matter, IEEE Sensors,
`Physical Review Letters, Microfluidics and Nanofluidics, Review of Scientific Instruments, Biomedical Microdevices,
`JMEMS, Biomacromolecules, Journal of the Royal Society – Interface, Sensors and Actuators B, IEEE Transactions of
`Biomedical Engineering, Biotechnology Progress, Analytical Chemistry, Journal of Micromechanics and MIcroengineering,
`The Analyst.
`
`Grant Review: NSF SBIR, NSF CBET, NIH IMAT, Pierre Gilles De Gennes Institute, NIH - Molecular and Cellular
`Hematology (MCH),
`JSPS (Japanese Society for the Promotion of Science), NIH - Cell, Molecular, and Computational
`Biology IMST, TATRC West, NIH Robotics SBIR, Army Research Office, NIH Challenge Grant, National Science and
`Technology Program for Nanoscience and Nanotechnology (Taiwan), AAAS RCP for KACST (Saudi Arabia) Program
`CHAIRING OF CONFERENCES & SYMPOSIA
`2017
`
`
`Co-chair
`
`
`
`
`Fundamentals and Applications of Microfluidic Compartmentalization
`2017
`
`
`Chair
`
`
`
`
` Gordon Research Conference (Physics and Chemistry of Microfluidics)
`2016
`
` Organizing Committee
`
`Biophysical Society – Mechanobiology of Disease Meeting
`2016
`
`
`Chair
`
`
`
`
`
`IEEE Micro & Nanotechnology in Medicine Conference
`2016
`
`
`Chair
`
`
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`
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`Society for Lab Automation and Screening (5000 attendee conference)
`2015
`
`
`Vice Chair
`
`
` Gordon Research Conference (Physics and Chemistry of Microfluidics)
`2014-present Founding Co-Chair
`
`Southern California Micro & Nanofluidics Symposium
`
`Service
`05/14-present Executive Committee
`01/14
`
`Track Chair
`
`
`12/13
`
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`Symposium Chair
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`
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`Ferrologix
`
` Omega Biosciences
`
`Tempo Therapeutics
`
`CytoVale Inc.
`
`
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`Vortex Biosciences
`
`NetScientific
`
`
`Cancer Nanotechnology Program, JCCC, Los Angeles
`
`Jonsson Comprehensive Cancer Center, Los Angeles
`
`California NanoSystems Institute, Los Angeles, CA
`
`
`Cue Inc.
`
`
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`
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`
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` Micro Total Analysis Systems Conference
`
`SLAS 2014 – Micro and Nano Devices
`
`International Conference on Biomedical Engineering
`
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`ABS Global, Inc. and Genus plc – Ex. 1004, p. 2
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`

`

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`Session Chair
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`Session Chair
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`Session Chair
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`Program Committee
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`Track Chair
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`Session Chair
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`Session Chair
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`Program Committee
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`Session Chair
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`Poster Judge
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` Poster Judge
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`Program Committee
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`Session Chair
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` Session Chair
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`Session Chair
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` Session Chair
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`
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`Biomedical Engineering Society Meeting – Micro & Nano
`
`Biomedical Engineering Society Meeting – Biomechanics
`
`UC Systemwide Bioengineering Symposium
`
` Micro Total Analysis Systems Conference
`
`SLAS 2013 – Micro and Nano Devices
`
`Biomedical Engineering Society Meeting - Diagnostics
`
`International Congress of Theoretical and Applied Mechanics
` Micro Total Analysis Systems Conference
`
`SLAS 2012 – Single-Cell Analysis and Cytometry
` Gordon Research Conference – Phys. & Chem. of Microfluidics
`
`UC Systemwide Bioengineering Symposium
` Micro Total Analysis Systems Conference
` Micro Total Analysis Systems Conference – Cell Analysis II Session
`
`UC Systemwide Bioengineering Symposium – Biomedical Devices Session
`
`Society of Rheology, Annual Meeting – Microfluidics Session
`
`UC Systemwide Bioengineering Symposium – New Frontiers
`
`
`Fluid Mechanics Course
`Computational Fluid Dynamics
`Engineering Design Course
`Bioengineering Lab
`
`
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`
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`
`
`09/13
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`09/13
`06/13
`05/13
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`01/13
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`10/12
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`09/12
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`05/12
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`02/12
`07/11
`06/11
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`05/11
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`10/10
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`06/10
`10/09
`06/09
`
`EDUCATIONAL ACTIVITIES
`
`Course Development
`2012
`
`
`Fluid-Structure Fluid-Particle Interactions in Microflows (BE 255)
`2009
`
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`Computational Bioengineering Design (BE 182B, 177A)
`
`
`2009
`
`
`Bioengineering Design Projects (BE 182C, 177B)
`
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`
`
`2008
`
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`Bioengineering Capstone Design (BE 182A, 167L)
`
`
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`
`
`Course Teaching
`Fall 2008, Spring 2009, Fall 2009, Spring 2010,
`
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`
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`Bioengineering Capstone Design (BE 182A)
`Spring 2011, Spring 2012, Spring 2013
`
`
`
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`Bioengineering Laboratory (BE 167L)
`
`
`Spring 2009, Fall 2009, Fall 2010
`
`
`
`Computational Bioengineering Design (BE 182B)
`Spring 2009, Winter 2010, Winter 2011
`
`
`
`Bioengineering Design Projects (BE 182C)
`
`
`Fluid-Structure Fluid-Particle Interactions in Microflows (BE 255) Winter 2012, Spring 2014, Spring 2015
`Bioengineering Capstone Design I (BE 177A)
`
`
`
`
`Fall 2011, 2012, 2013, 2014, 2015
`Bioengineering Capstone Design II (BE 177B)
`
`
`
` Winter 2012, 2013, 2014, 2015, 2016
`
`ADVISEES: (10 Postdocs, 24 Ph.D., 2 M.S., 32 B.S.) – Current positions include Assistant Professor Johns Hopkins,
`Professor University of Tokyo, Assistant Professor KAIST, Assistant Professor RPI, CSO Vortex Biosciences, VP of R&D
`CytoVale, Scientist II Illumina, Scientist Genapsys, Scientist BD Biosciences, Adjunct Assistant Professor UCLA, CEO
`Tempo Therapeutics, CEO Ferrologix.
`
`Graduate
`Ph.D. 2016-present
`Joseph de Rutte
`Ph.D. 2014-present
`Jaekyung Koh
`
`Ph.D. 2014-present
`Andy Tay
`
`
`Ph.D. 2014-present
`Armin Karimi
`
`Jonathan Lin
` M.D./Ph.D. 2013-present
`Manjima Dhar
`
`Ph.D. 2013-present
`Soroush Kakhestani Ph.D. 2013-present
`Reem Khojah
`
`Ph.D. 2013-present
`Enrique Munoz
`Ph.D. 2013-present
`Ivan Pushkarsky
`Ph.D. 2013-present
`Janay Kong
`
`Ph.D. 2012-present
`Harsha Kittur
`
`Ph.D. 2012-present
`Jerry Wu
`
`
`Ph.D. 2012-present
`Keegan Owsley
`Ph.D. 2012-present
`Oladunni Adeyiga Ph.D. 2011-present
`James Che
`
`Ph.D. 2012-2015
`Coleman Murray
`Ph.D. 2010-2015
`Mahdokht Masaeli Ph.D. 2010-2013
`Hamed Amini
`
`Ph.D. 2009-2012
`
`Current Position: Scientist, Vortex Biosciences
`Current Position: CEO, Ferrologix
`Current Position: Scientist, Genapsys
`Current Position: Scientist II, Illumina Inc.
`
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`ABS Global, Inc. and Genus plc – Ex. 1004, p. 3
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`

`

`Current Position: CEO, Tempo Therapeutics
`Current Position: Program Officer, NIH
`Current Position: Scientist, Becton Dickinson
`Current Position: Vice President of Systems Engineering, Cytovale Inc.
`Current Position: Postdoctoral Scholar, Tufts Univ.
`Current Position: Rowland Fellow at Harvard University
`Current Position: University of Cincinnati M.D. Program
`Current Position: CEA Leti, France
`
`
`
`
`
`
`
`Westbrook Weaver Ph.D. 2008-2013
`Daniel R. Gossett Ph.D. 2008-2012
`Albert Mach
`
`Ph.D. 2008-2012
`Henry Tse
`
`Ph.D. 2008-2012
`Peter Tseng
`
`Ph.D. 2008-2012
`Soojung Claire Hur Ph.D. 2008-2011
`Derek Go
`
` M.S.
`2013-2014
`Dianne Pulido
` M.S.
`2011-2012
`
`Postdoctoral Fellows Sponsored
`Carson Riche
`
`2016-present Ph.D. University of Southern California, 2015
`Hamed Haddadi
`2014-present Ph.D. City University of New York, 2014
`Ming Li
`
`
`2014-present Ph.D. University of Wollongong, Australia, 2013
`Eric Diebold
`
`2014-2015
`Ph.D. Harvard University
`
`
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`
`
`Current Position: Founder and President, Omega Biosystems
`Donghyuk Kim
`2013-present Ph.D. University of Minnesota, 2013
`
`
`Anja Kunze
`
`2012-2015
`Ph.D. EPFL, Switzerland, 2011
`
`
`Current Position: Adjunct Assistant Professor Mathematics, UCLA, Los Angeles, USA
`Michael Masterman-Smith 2012-2013 Ph.D., UCLA, 2010
`
`
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`Current Position: Co-founder, Harmony Biosciences, Inc.
`Aram Chung
`
`2011-2013
`Ph.D. Cornell University, 2011
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`Current Position: Assistant Professor, Rensselaer Polytechnic Institute, NY, USA
`Keisuke Goda
`
`2011-2012
`Ph.D. MIT
`
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`Current Position: Professor, University of Tokyo, Tokyo, JAPAN
`Elodie Sollier
`
`2010-2012
`Ph.D. CEA LETI, Grenoble 2009
`
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`
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`Current Position: Vice President of R&D, Vortex Biosciences, Menlo Park, USA
`Wonhee Lee
`
`2009-2011
`Ph.D. Applied Physics, Cal Tech 2008
`
`Current Position: Assistant Professor, KAIST, Daejon, KOREA
`
`
`
`2015
`2015
`2014
`2014
`
`2013
`
`2013
`2011-2012
`2011
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`2011
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`Visiting Scholars
`B.S.
`Rishav Roy
`
`Petra Paie’
` M.S.
`Rogier Schoeman M.S.
`Celia Fouques
`B.S.
`Melanie Triboulet B.S.
`Tiancheng Fang
`B.S.
`Patrick Sandoz M.S.
`Yi Xu
`
`
`
`B.S.
`Pietro Maoddi
`
`B.S.
`
`
`Undergraduate
`Noor Ahmed, Shivani Dharmaraja, Daniel Heikali, Tihut Kebede, Steven Behrens, Jae Hyun Kim, Andy Lee, Marc Lim,
`Laura Mullens, Chih Ann Yih, Erika Fong, Armin Arshi, Jaideep Dudani, Michelle Wong, Ish Talati, Derek Go, Grace
`Kwong, Tiffany Leung, Dewal Gupta, Viviana Ogawa, Anna Nonaka, Shayan Aftab, Yeganeh Amini, Avery Hua, Dylan
`Black, Margaret Phiukhao, Jessica Wong, Victor Yu, Maxwell Johnson, Lillian Peng, Andrew Jann.
`
`
`PATENTS: (43 applications, 13 issued)
`
`43. Di Carlo D, Kong J. inventors; Regents of the University of California, assignee. Enhanced fluorescent readout.
`Provisional Application Filed (62/337,433).
`
`42. Di Carlo D, Weaver WM, Griffin DR, Koh J. inventors; Regents of the University of California, assignee. Continuous
`analyte sensing using microporous particle gels. Provisional Application Filed (62/281,660).
`
`41. Di Carlo D, Murray CT, Pao E. inventors; Regents of the University of California, assignee. Cytometry using magnetic
`arrays. Provisional Application Filed (62/287,219).
`
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`ABS Global, Inc. and Genus plc – Ex. 1004, p. 4
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`40. Di Carlo D, Murray CT, Pao E, Tseng P. inventors; Regents of the University of California, assignee. Ferromagnetic
`micro-pillar arrays. Provisional Application Filed (62/262,294).
`
`39. Di Carlo D, Kahkeshani S. inventors; Regents of the University of California, assignee. Controllable emulsification.
`Provisional Application Filed (62/241,917).
`
`38. Di Carlo D, Murray CT, Dhar M, Pao E. inventors; Regents of the University of California, assignee. Magnetic
`ratcheting. Provisional Application Filed (62/238,387).
`
`37. Di Carlo D, Che J. inventors; Regents of the University of California, assignee. Mechanophenotyping platform.
`Provisional Application Filed (62/245,879).
`
`36. Di Carlo D, Wu C-Y. inventors; Regents of the University of California, assignee. Culture and adhesive flow cytometry.
`Provisional Application Filed (62/236,782).
`
`35. Di Carlo D, Dhar M. inventors; Regents of the University of California, assignee. Chip for trapping tumor cells.
`Provisional Application Filed (62/180,990).
`
`34. Ozcan, A; Di Carlo, D; Feng, SW; Tseng, D; Cortazar Unzaga, B; Berg, B; Ozkan, H; Garner, O. inventors; Regents of
`the University of California, assignee. Cell-phone based microplate. Provisional Application Filed (62/182,312).
`
`33. Di Carlo D, Kim D. inventors; Regents of the University of California, assignee. HEBA. Provisional Application Filed
`(62/127,050).
`
`32. Di Carlo D, Kong J. inventors; Regents of the University of California, assignee. Homogenous isothermal amplification.
`Provisional Application Filed (62/121,717).
`
`31. Di Carlo D, Wu C-Y. inventors; Regents of the University of California, assignee. Particle manipulation. Provisional
`Application Filed (62/068,520).
`
`30. Di Carlo D, Tseng P, Murray CT. inventors; Regents of the University of California, assignee. Ferromagnetic tape.
`Provisional Application Filed (62/092,142).
`
`29. Di Carlo D, Kittur H. inventors; Regents of the University of California, assignee. Cell Adhesion Profiler. Provisional
`Application Filed 6/18/2014 (62/025,363).
`
`28. Segura T, Di Carlo D, Weaver WM, Griffin DR, Scumpia P. inventors; Regents of the University of California,
`assignee. Self-annealing Microgels. Provisional Application Filed 5/15/2014 (62/025,844).
`
`27. Di Carlo D, Pushkarsky I, Tseng P. inventors; Regents of the University of California, assignee. Arrayed Force
`Phenotyping. Provisional Application Filed 3/11/2014 (61/972,171).
`
`26. Di Carlo D, Go DE, Masaeli M, Sollier E. inventors; Regents of the University of California, assignee. Analysis of
`Rare, Large Cells. Provisional Application Filed 6/26/2014 (62/018,415).
`
`25. Di Carlo D, Kong J. inventors; Regents of the University of California, assignee. Homogenous Amplified Detection.
`Provisional Application Filed 10/18/2013 (61/892,932).
`
`24. Di Carlo D, Masaeli M, Gossett D. inventors; Regents of the University of California, assignee. Method and Device for
`Enrichment of Cells by Deformed Shape. Provisional Application Filed 8/26/2013 (61/870,121).
`
`23. Di Carlo D, Dudani J, Gossett D, Go D, Tan A. inventors; Regents of the University of California, assignee. In-
`suspension Colorimetric Staining. Provisional Application Filed 6/21/2013 (61/838,160).
`
`22. Di Carlo D, Masaeli M, Sollier E, inventors; Regents of the University of California, assignee. Method of Separating
`Particles by Shape. U.S. Patent # 9,333,510. Granted 5/10/2016. Chinese Patent # ZL 2012800594140. Granted
`2/24/2016.
`
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`ABS Global, Inc. and Genus plc – Ex. 1004, p. 5
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`21. Di Carlo D, Amini H, Sollier E, inventors; Regents of the University of California, assignee. Devices and methods for
`programming fluid flow using sequenced microstructures. International Patent Application # (PCT/US2012/057641). Filed
`9/27/2012.
`
`20. Di Carlo D, Gossett DR, Tse HTK, inventors; Regents of the University of California, assignee. Deformability
`Measurements. US Patent Application # (14/057,942). Filed 10/18/2013.
`
`19. Di Carlo D, Gossett DR, Tse HTK, inventors; Regents of the University of California, assignee. Deformability
`Measurements. U.S. Patent # 9,151,705 B2. Granted October 6 2015.
`
`18. Di Carlo D, Gossett DR, Tse HTK, inventors; Regents of the University of California, assignee. Inertial Solution
`Exchange. International Patent Application # (PCT/US2011/060536). Filed 11/14/2011.
`
`17. Di Carlo D, Gossett DR, Weaver WM, inventors; Regents of the University of California, assignee. Sequential Array
`Cytometry. U.S. Patent # 9,222,870. Granted Dec 29 2015.
`
`16. Di Carlo D, Lee W, inventors; Regents of the University of California, assignee. Control of Particle Placement and
`Spacing in Channel Flows. International Patent Application # (PCT/US2011/060573). Filed 11/14/2011.
`
`15. Di Carlo D, Amini H, inventors; Regents of the University of California, assignee. Enhancement of Mass Transfer in
`Channel Flow. Provisional Patent Filed 9/29/2011 (61/540,990).
`
`14. Di Carlo D, Hur SC, Mach A, inventors; Regents of the University of California, assignee. Isolation of Larger Target
`Cells from Heterogenous Solution using Microfluidic Cancer Cell Trapping Vortex. U.S. Patent # 9,133,499. Granted Sep
`15 2015. Chinese Patent # CN103261436. Granted Mar 5 2015. Japanese Patent # 5920895. Granted May 25 2016.
`
`13. Di Carlo D, Gossett DR, Tse HTK, inventors; Regents of the University of California, assignee. Tool for High-
`throughput Cell Deformability Measurements. U.S. Patent # 8,935,098. Granted Jan 13, 2015.
`
`12. Di Carlo D, Ozcan A, Jalali B, Tse HTK, Hur SC, inventors; Regents of the University of California, assignee. Inertial
`particle focusing flow cytometer. U.S. Patent # 8,693,762. Granted April 8, 2014.
`
`10. Di Carlo D, Tseng P, Judy JW, inventors; Regents of the University of California, assignee. Methods for Dynamic
`Modification of Localized Cellular Environments. US Patent Application # (13/172,655). Filed 6/29/2011.
`
`9. Di Carlo D, Mach A, inventors; Regents of the University of California, assignee. High-Throughput Filter-Less Cell
`Separation for Rapid Sepsis Therapy. Patent pending (UCLA Case No.:2009-672)
`
`8. Di Carlo D, Gossett DR, inventors; Regents of the University of California, assignee. Inertial Particle Focusing
`Systems. U.S. Patent # 8,361,415. Granted Jan 29, 2013.
`
`7. Di Carlo D, Hur SC, inventors; Regents of the University of California, assignee. Systems and Methods for
`Deformability Activated Cell Sorting. U.S. Patent # 9,090,865. Granted July 28, 2015.
`
`6. Di Carlo D, Edd JF, Irimia D, Toner M, inventors; Partners Healthcare, assignee. Microfluidic Droplet Encapsulation.
`U.S. Patent # 9,068,181. Granted Jun 30, 2015.
`
`5. Di Carlo D, Kane R, Toner M, inventors; Partners Healthcare, assignee. Particle Sizing by Inertial Ordering
`Equilibrium Position. Patent pending (MGH 20045).
`
`4. Di Carlo D, Irimia D, Toner M, inventors; Partners Healthcare, assignee. Systems and Methods for Particle Focusing
`in Microchannels. U.S. Patent #8,186,913. Granted May 29, 2012. U.S. Patent # 8,784,012. Granted Jul 22, 2014. U.S.
`Patent # 8,807,879. Granted Aug 19, 2014. Chinese Patent #CN 101765762. Granted Aug 14, 2013.
`
`3. Di Carlo D, Nevill JT, Lee LP, inventors; Regents of the University of California, assignee. Microfluidic Methods for
`Diagnostics and Cellular Analysis. Patent Application # (11/990,130) International Patent WO/2007/024701. Filed August
`18, 2006.
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`2. Di Carlo D, Ionescu-Zanetti C, Hung P, inventors; Regents of the University of California, assignee. Efficient On-Chip
`Sample Preparation. Patent pending (UCB Case No.:B05-021).
`
`1. Di Carlo D, Lee LP, inventors; Regents of the University of California, assignee. High Density Single Cell Array Chip.
`Patent pending (UCB Case No.:B06-023).
`
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`PUBLICATIONS: (7855 citations, h-index 40, m-index 3.08, 84 original journal articles, 11 review articles, 5 books
`and book chapters, 72 published proceedings of meetings)
`
`Original Articles
`
`84. Dhar M, Pao E, Renier C, Go DE, Che J, Montoya R, Conrad R, Matsumoto M, Heirich K, Triboulet M, Rao
`J, Jeffrey SS, Garon E, Goldman J, Rao NP, Kulkarni R, Sollier E, Di Carlo D. Label-free enumeration,
`collection and downstream cytological and cytogenetic analysis of circulating tumor cells. Scientific Reports.
`2016. (in press)
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`83. Sideris E, Griffin DR, Ding Y, Li S, Weaver WM, Di Carlo D, Hsiai T, Segura T. Particle hydrogels based on hyaluronic
`acid building blocks. ACS Biomaterials Science & Engineering. 2016. (in press).
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`82. Kim D, Garner OB, Ozcan A, Di Carlo D. Homogeneous Entropy-Driven Amplified Detection of Biomolecular
`Interactions. ACS Nano. 2016. 10 (8), 7467-7475.
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`81. Sung K, Ding Y, Ma J, Chen H, Huang V, Cheng M, Yang CF, Kim JT, Eguchi D, Di Carlo D, Hsiai TK, Nakano A,
`Kulkarni RP. Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping. Scientific
`Reports. 2016. 6:30736. doi: 10.1038/srep30736.
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`80. Lei C, Ito T, Ugawa M, Nozawa T, Iwata O, Maki M, Okada G, Kobayashi H, Sun X, Tiamsak P, Tsumura N, Suzuki K,
`Di Carlo D, Ozeki Y, Goda K. High-throughput label-free image cytometry and image-based classification of live Euglena
`gracilis. Biomedical Optics Express. 2016. 7:2703-8. doi: 10.1364/BOE.7.002703.
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`79. Koziol-White CJ, Yoo EJ, Cao G, Zhang J, Papanikolaou E, Pushkarsky I, Andrews A, Himes BE, Damoiseaux RD,
`Liggett SB, Di Carlo D, Kurten RC, Panettieri RA Jr. Inhibition of PI3K promotes dilation of human small airways in a rho
`kinase-dependent manner. British Journal of Pharmacology. 2016. doi: 10.1111/bph.13542.
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`78. Hood K, Kahkeshani S, Di Carlo D, Roper M. Direct Measurement of Particle Inertial Migration in Rectangular
`Microchannels. Lab on a Chip. 2016.16(15):2840-50. doi: 10.1039/c6lc00314a.
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`77. Kahkeshani S, Di Carlo D. Drop formation using ferrofluids driven magnetically in a step emulsification device. Lab on
`a Chip. 2016. 16(13):2474-80. doi: 10.1039/c6lc00645k.
`
`76. Tay A, Kunze A, Jun D, Hoek E, Di Carlo D. The Age of Cortical Neural Networks Affects Their Interactions with
`Magnetic Nanoparticles. Small. 2016. doi: 10.1002/smll.201600673.
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`75. Che J, Yu V, Dhar M, Renier C, Matsumoto M, Heirich K, Garon EB, Goldman J, Rao J, Sledge GW, Pegram MD,
`Sheth S, Jeffrey SS, Kulkarni RP, Soller E, Di Carlo D. Classification of large circulating tumor cells isolated with ultra-
`high throughput microfluidic Vortex technology. Oncotarget. 2016. doi: 10.18632/oncotarget.7220
`
`74. Murray CT, Pao E, Tseng P, Aftab S, Kulkarni RP, Rettig MB, Di Carlo D. Quantitative Magnetic Separation of
`Particles and Cells using Gradient Magnetic Ratcheting. Small. 2016. 12 (14), 1891-1899.
`
`73. Tay A, Kunze A, Murray C, Di Carlo D. Induction of calcium influx in cortical neural networks by nano-magnetic
`forces. ACS Nano. 2016. 10 (2), 2331-2341.
`
`72. Kim J, Lee J, Wu CY, Nam SM, Di Carlo D, Lee W. Inertial focusing in non-rectangular cross-section microchannels
`and manipulation of accessible focusing position. Lab on a Chip. 2016. 16 (6), 992-1001.
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`71. Stoecklein D, Wu CY, Kim D, Di Carlo D, Ganapathysubramanian B. Optimization of micropillar sequences for fluid
`flow sculpting. Physics of Fluids. 2016 28 (1), 012003.
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`70. Dhar M, Wong J, Karimi A, Che J, Renier C, Matsumoto M, Triboulet M, Garon EB, Goldman JW, Rettig MB, Jeffrey
`SS, Kulkarni RP, Sollier E and Di Carlo D. High efficiency vortex trapping of circulating tumor cells. Biomicrofluidics.
`2015 9, 064116; doi: 10.1063/1.4937895
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`69. Kahkeshani S, Haddadi H, Di Carlo D. Preferred interparticle spacings in trains of particles in inertial microchannel
`flows. Journal of Fluid Mechanics. 2015 doi: 10.1017/jfm.2015.678
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`68. Wu C-Y, Owsley K, Di Carlo D. Rapid Software-Based Design and Optical Transient Liquid Molding of Microparticles.
`Advanced Materials. 2015. doi: 10.1002/adma.201503308.
`
`67. Ugawa M, Lei C, Nozawa T, Ideguchi T, Di Carlo D, Ota S, Ozeki Y, Goda K. High-throughput optofluidic particle
`profiling with morphological and chemical specificity. Opt Lett. 2015 Oct 15;40(20):4803-6. doi: 10.1364/OL.40.004803.
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`66. Berg B, Cortazar B, Tseng D, Ozkan H, Feng S, Wei Q, Chan RY, Burbano J, Farooqui Q, Lewinski M, Di Carlo D,
`Garner OB, Ozcan A. Cellphone-Based Hand-Held Micro-Plate Reader for Point-of-Care Testing of Enzyme-Linked
`Immunosorbent Assays. ACS Nano. 2015;9(8):7857-66. doi: 10.1021/acsnano.5b03203.
`
`65. Kumar A, Lewis P, Balonis M, Di Carlo D, Sant G. On the Application of Inertial Microfluidics for the Size-Based
`Separation of Polydisperse Cementitious Particulates. Frontiers in Materials. 2015 doi:10.3389/fmats.2015.00048
`
`64. Griffin DR, Weaver WM, Scumpia P, Di Carlo D*, Segura T*. Accelerated wound healing by injectable microporous
`gel scaffolds assembled from annealed building blocks. Nature Materials. 2015 14(7):737-44. doi: 10.1038/nmat4294..
`*co-corresponding authors.
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`63. Paulsen KS, Di Carlo D*, Chung AJ*. Optofluidic 3D shaped particle fabrication. Nature Communications. 2015
`2015 6:6976. doi: 10.1038/ncomms7976. *co-corresponding authors.
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`62. Sollier E, Amini H, Go DE, Sandoz P, Owsley K, Di Carlo D. Inertial microfluidic programming of microparticle-laden
`flows for solution transfer around cells and particles. Microfluidics and Nanofluidics. 2015 (in press).
`
`61. Kunze A, Tseng P, Godzich C, Murray C, Caputo A, Schweizer FE, Di Carlo D. Engineering Cortical Neuron Polarity
`with Nanomagnets on a Chip. ACS Nano. 2015 9(4):3664-76. doi: 10.1021/nn505330w.
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`60. Dudani JS, Gossett DR, Tse HT, Lamm RJ, Kulkarni RP, Di Carlo D. Rapid inertial solution exchange for enrichment
`and flow cytometric detection of microvesicles. Biomicrofluidics. 2015;9(1):014112. doi: 10.1063/1.4907807
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`59. Tseng P, Lin J, Owsley K, Kong J, Kunze A, Murray C, Di Carlo D. Flexible and stretchable micromagnet arrays for
`tunable biointerfacing. Advanced Materials. 2015; 27(6):1083-9. doi: 10.1002/adma.201404849.
`
`58. Tseng P, Pushkarsky I, Di Carlo D. Metallization and biopatterning on ultra-flexible substrates via dextran sacrificial
`layers. PLoS ONE. 2014; 9(8):e106091. doi: 10.1371/journal.pone.0106091.
`
`57. Stoecklein D, Wu, C-Y, Owsley K, Xie Y, Di Carlo D, and Ganapathysubramanian B. Micropillar sequence designs for
`fundamental inertial flow transformations. Lab on a Chip. 2014; 14(21):4197-204. doi: 10.1039/c4lc00653d.
`
`56. Sandoz PA, Chung AJ, Weaver WM, Di Carlo D. Sugar additives improve signal fidelity for implementing two-phase
`resorufin-based enzyme immunoassays. Langmuir. 2014; 30(23):6637-43. doi: 10.1021/la5004484.
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`55. H Kittur, W Weaver, D Di Carlo. Well-plate mechanical confinement platform for studies of mechanical mutagenesis.
`Biomedical Microdevices. 2014; 16(3):439-447.
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`54. Pushkarsky I, Lyb Y, Weaver W, Su T-W, Mudanyali O, Ozcan A, Di Carlo D. Automated single-cell motility analysis
`on a chip using lensfree microscopy. Scientific Reports. 2014; 4:4717. doi: 10.1038/srep04717.
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`53. Nunes JK, Wu CY, Amini H, Owsley K, Di Carlo D, Stone HA. Fabricating Shaped Microfibers with Inertial
`Microfluidics. Advanced Materials. 2014; 26(22):3712-7. doi: 10.1002/adma.201400268.
`
`52. Chen Y, Chung AJ, Wu TH, Teitell MA, Di Carlo D, Chiou PY. Pulsed Laser Activated Cell Sorting with Three
`Dimensional Sheathless Inertial Focusing. Small. 2014; 10(9):1746-51. doi: 10.1002/smll.201302885.
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`51. Substrates with patterned extracellular matrix and subcellular stiffness gradients reveal local biomechanical
`responses. Tseng P, Di Carlo D. Advanced Materials. 2014; 26(8):1242-7. doi: 10.1002/adma.201304607.
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`50. Dudani JS, Go DE, Gossett DR, Tan AP, Di Carlo D. Mediating millisecond reaction times around particles and cells.
`Analytical Chemistry 2014; 86(3):1502-10. doi: 10.1021/ac402920m.
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`49. Tse HTK, Gossett DR, Moon YS, Masaeli M, Sohsman M, Ying Y, Mislick K, Adams RP, Rao J, Di Carlo D.
`Quantitative Diagnosis of Malignant Pleural Effusions by Single-Cell Mechanophenotyping. Science Translational
`Medicine 2013; 5(212):212ra163. doi: 10.1126/scitranslmed.3006559. (Highlighted in Science Translational Medicine)
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`48. Tan AP, Dudani JS, Arshi A, Lee RJ, Tse HTK, Gossett DR, Di Carlo D. Continuous-flow cytomorphological staining
`and analysis. Lab on a Chip 2014; 14(3):522-31. doi: 10.1039/c3lc50870f.
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`47. Che J, Mach AJ, Go DE, Talati I, Ying Y, Rao J, Kulkarni RP, Di Carlo D. Microfluidic Purification and Concentration
`of Malignant Pleural Effusions for Improved Molecular and Cytomorphological Diagnostics. PLoS ONE 2013;
`8(10):e78194. doi: 10.1371/journal.pone.0078194.
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`46. Sollier E, Go DE, Che J, Gossett DR, O’Byrne S, Weaver WM, Kummer N, Rettig M, Goldman J, Nickols N,
`McCloskey S, Kulkarni RP, Di Carlo D. Size-Selective Collection of Circulating Tumor Cells using Vortex Technology.
`Lab on a Chip 2014; 14(1):63-77. doi: 10.1039/c3lc50689d.
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`45. Dudani JS, Gossett DR, Tse HT, Di Carlo D. Pinched-flow hydrodynamic stretching of single-cells. Lab on a Chip
`2013;13(18):3728-34. doi: 10.1039/c3lc50649e
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`44. Amini H, Sollier E, Masaeli M, Xie Y, Ganapathysubramanian B, Stone HA, Di Carlo D. Engineering fluid flow using
`sequenced microstructures. Nature Communications 2013; 4:1826. doi: 10.1038/ncomms2841. (Highlighted in Lab on a
`Chip)
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`43. Chung A, Pulido D, Oka J, Amini H, Masaeli M, Di Carlo D. Microstructure-induced helical vortices allow single-
`stream and long-term inertial focusing. Lab on a Chip 2013; 13(15):2942-9. doi: 10.1039/c3lc41227j
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`42. Chung A, Gossett DR, Di Carlo D. Three Dimensional, Sheathless, and High-Throughput Microparticle Inertial
`Focusing Through Geometry-Induced Secondary Flows. Small 2013; 9(5):685-90. doi: 10.1002/smll.201202413.
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`41. Murray C, McCoul D, Sollier E, Ruggiero T, Niu X, Pei Q, Di Carlo D. Electro-adaptive microfluidics for active tuning
`of channel geometry using polymer actuators. Microfluidics and Nanofluidics 2012; doi:10.1007/s10404-012-1055-y.
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`40. Hur SC, Brinckerhoff TZ, Walthers CM, Dunn JCY, Di Carlo D. Label-free enrichment of adrenal cortical progenitor
`cells using intertial microfluidics. PLoS ONE. 2012; 7:e46550. doi:10.1371/journal.pone.0046550.
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`39. Tseng P, Judy JW, Di Carlo D. Magnetic nanoparticle-mediated massively-parallel mechanical modulation of single-
`cell behavior. Nature Methods. 2012; 9:1113–1119.
`
`38. Amini H, Sollier E, Weaver WM, Di Carlo D. Intrinsic particle-induced lateral transport in microchannels. Proceedings
`of the National Academy of Sciences USA. 2012; 109:11593-8. (Highlighted in Lab on a Chip)
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`37. Goda K, Ayazi A, Gossett DR, Sadasivam J, Lonappan CK, Sollier E, Fard AM, Hur SC, Adam J, Murray C, Wang C,
`Brackbill N, Di Carlo D, Jalali B. High-throughput single-microparticle imaging flow analyzer. Proceedings of the
`National Academy of Sciences USA. 2012; 109:11630-5. (Highlighted in Time Magazine, Optics and Photonics News,
`and PNAS, front page on reddit) (Cited 94 times)
`
`36. Masaeli M, Sollier E, Amini H, Mao W, Camacho K, Doshi N, Mitragotri S, Alexeev A, Di