J. David Rozzell, PhD
`Experienced consultant and executive in the life sciences, founder or co-founder of
`three companies, including BioCatalytics, Inc., a leading developer and producer of
`enzymes for pharmaceutical manufacturing and diagnostic use; and Sustainable
`Chemistry Solutions, Inc, a consultancy and provider of information products for the
`enzyme and biocatalysis industries and publisher of the Enzyme Industry Newsletter.
`Tel: +1-818-388-6576
`E-Mail: drozzell@provivi.com or jdrozzell@gmail.com
`
`Education
`
`University of Virginia
`Harvard University
`Harvard Business School
`
`Chemistry
`1978
`B.S.
`Chemistry
`1983
`Ph.D.
`Summer Business Program, 1982
`
`Positions and Employment
`Genetics Institute, Inc., Cambridge, MA
`1983-1986; Senior Scientist
`1986-1988; Director of Biocatalysis Research
`Built and managed an interdisciplinary group reaching the size of 8 professionals.
`Directed the research and development activities of the Applied Enzymology and
`Biocatalysis groups. Efforts resulted in more than $1 million in revenues through funding
`and license agreement, and the commercialization of processes to manufacture
`optically active amino acids at the multi-hundred ton per year scale.
`Celgene Corporation, Warren, NJ
`1988-1991; Director of Research and Biotreatment Systems
`Responsibility for directing both proprietary and collaborative research programs
`focused on the production of pharmaceutical intermediates and specialty chemicals.
`Technology employed a combination of biocatalytic reactions and organic chemistry.
`Exogene Corporation, Monrovia, CA
`1991-1992; Vice-President of Research & Development
`1992-1994; President
`Responsible for business development, negotiation of sponsored research and
`technology licensing agreements, general scientific guidance of the company's
`research, and supervision of the administrative and senior scientific staff.
`EraGen Biosciences, Inc., Madison, WI
`
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`1994-1996: Founder and Acting CEO
`Co-founded a start-up biotechnology company focused on applications of non-standard
`nucleic acid bases and protein structure prediction. Raised seed capital from individual
`investors and the Novartis Venture Fund. Acted as CEO until full-time person was
`recruited to establish the company in its first headquarters in Florida.
`BioCatalytics, Inc., Pasadena, CA
`1996-July 2007: Founder, President, CSO and CEO
`Established a biotechnology company to develop and commercialize enzymes and
`enzyme-based processes for the production of optically active pharmaceutical
`intermediates and other specialty chemicals. Built company into a profitable seller of
`novel enzymes for chemical synthesis, with the world’s largest enzyme product line.
`Established a European office in 2005 and a subsidiary BioCatalytics Europe GmbH in
`Graz, Austria in 2006. BioCatalytics, Inc. was acquired in July 2007 by Codexis, Inc.
`Codexis, Inc., Pasadena, CA
`July 2007-Oct 2008, VP, Biocatalysis Technology and Applications
`Joined Codexis, Inc, as VP following acquisition of BioCatalytics by Codexis, Inc.
`Responsible for the identification and development of new technologies, including
`technologies developed and in-licensed through external collaborations. Managed a
`network of external collaborations in the USA and Europe. Promoted the company and
`supported business development activities through technical presentations, press
`conferences, and written articles. Initiated an emphasis on Green Chemistry.
`Solidus Biosciences, Inc., San Francisco, CA
`March 2009-October 2010, President & CEO
`Hired as President and CEO to lead a company with a novel, chip-based in vitro
`toxicology platform. Responsible for managing company operations, setting business
`strategy, developing new customer relationships, and raising funds from investors.
`Sustainable Chemistry Solutions, Inc., Burbank, CA
`January 2012-2015, Founder and CEO
`Publisher, founder, and owner of the web site http://www.bio-catalyst.com focusing on
`providing information and insights on biofuels, bio-based chemicals, and biocatalysis.
`Publisher of monthly newsletter Enzyme Industry Newsletter. Offer information products
`and consulting services related to enzymes and biocatalysis to pharmaceutical and
`chemical companies. Provide consulting support to programs for the development of
`novel enzymes and their applications, and also for pathways in bio-based chemical
`production. Creator and publisher of the Enzyme Company Guide and the Biocatalysis
`Enzyme Guide, providing business and technical information to industry specialists.
`Also offer expert witness services in patent litigation and cases involving enzymes and
`the development and enzyme-based processes and applications.
`Catylix, Inc., Burbank, CA
`
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`February 2011-2015, CEO and Co-Founder with Professor John F. Hartwig
`Established company to develop and commercialize a novel, broadly-useful chemistry
`for adding fluorine-containing functional groups to chemical compounds. First product
`launched in July 2011. Main product applications are in the discovery of
`pharmaceuticals and crop protection agents with improved efficacy and metabolic
`stability.
`
`Provivi, Inc. Santa Monica, CA
`August 2015-Present, Sr. Vice-President, Biocatalysis
`Joined Provivi, Inc., an early-stage biotechnology company, to lead development and
`commercialization of novel enzymes catalyzing the synthesis of chiral cyclopropanes via
`a carbene transfer mechanism. Responsibilities include managing internal R & D,
`business development, customer acquisition and project management to meet rigorous
`timelines for development.
`
`
`Other Work Experience
`
`Consultant and Member of Scientific Advisory Board
`Wella AG, Darmstadt, Germany
`Served as member of scientific advisory board and provided consulting assistance to
`the biotechnology program established by Wella AG, the German Cosmetic and hair
`care company. Inventor on two patents for the coloration and modification of the
`properties of hair using enzymes. Wella AG was acquired by Procter & Gamble in 2003.
`
`Advisory Board Member, Eucodis Biosciences, Vienna, Austria (2011-2013)
`
`Consultant and Scientific Advisor, Almac Sciences, Craigavon, United Kingdom
`(2010 to present)
`
`Organizer of International Symposium “Development and Application of enzymes
`in Biotechnology” sponsored by Informa Group and held in Duesseldorf, Germany,
`April 14-15, 2015
`
`Honors
`Co-Chair, Gordon Conference on Biocatalysis, 1992
`Chairman and Organizer and Speaker at various international symposia on enzymes
`and biocatalysis
`Member of Editorial Board, Journal of Industrial Microbiology
`Member of Industrial Advisory Board, Journal of Advanced Synthesis and Catalysis
`Member of Board of Directors, EraGen Biosciences, Inc., Madison, WI
`Member of Board of Directors, Pasadena Bioscience Center
`Member of Advisory Board, Los Angeles-Orange County Biotechnology Center
`Member, Blue Ribbon Steering Committee, Life Sciences Summit for Southern
`California
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`Selected Publications
`1. "Stereospecificity and Stereochemical Infidelity of Acetoacetate Decarboxylase
`(AAD)": Steven A. Benner, J. David Rozzell, and Thomas Hellman Morton; J. Am.
`Chem. Soc., 103, 993-4 (1981).
`2. "Preparation of Diastereomeric 2-Deuterio-3-Hydroxybutyrate. A General Method for
`Hydrogenation of ß-Acyloxy-alpha, beta-Unsaturated Crotonates": J. David Rozzell;
`Tetrahedron Letters, 23, 1767- 70 (1982).
`3. "Rearrangement of 4,4-Diarylcyclohexadienones Induced By Attack of Methyl
`Metaphosphate at the Carbonyl Group": Kim C. Calvo, J. David Rozzell, and F. H.
`Westheimer; J. Am. Chem. Soc., 105, 1693-4 (1983).
`4. "Combining Enzymatic and Chemical Steps in the Synthesis of Biologically Valuable
`Compounds: Isotopically Chiral Methyl Acetate": Steven A. Benner and J. David
`Rozzell; J. Org. Chem., 48, 1190-93 (1983).
`5. "Stereochemical Imperative in Enzymic Decarboxylations. Stereochemical Course
`of the Decarboxylation Catalyzed by Acetoacetate Decarboxylase": J. David Rozzell
`and Steven A. Benner; J. Am. Chem. Soc., 106, 4937-41 (1984).
`6. "Enzymatic Catalysis in Organic Media": J. S. Deetz and J. David Rozzell; The
`World Biotech Report 1986, 2, 25-33 (1986).
`7. "Immobilized Aminotransferases for Amino Acid Production": J. David Rozzell;
`Methods in Enzymology, 136, 479-97 (1987).
`8. "The Stereospecificity of Oxaloacetate Decarboxylase--A Stereochemical
`Imperative?": Joseph A. Picciirilli, J. David Rozzell, and Steven A. Benner; J. Am.
`Chem. Soc., 109, 8084-5 (1987).
`9. "Enzyme-Catalyzed Reactions in Non-Aqueous Media": Jeffrey S. Deetz and J.
`David Rozzell; Trends in Biotechnology, 6, 15-19 (1988).
`10. "Enzymatic Catalysis in Non-Aqueous Media": Jeffrey S. Deetz and J. David
`Rozzell; Annals of the New York Academy of Sciences, 230-234 (1988).
`11. "Production of Cyclodextrins Using Immobilized Enzymes": Steven P. Crump and J.
`David Rozzell; Proceedings of the 4th International Symposium on Cyclodextrins,
`47-53, Kluwer Academic Publishers (1988).
`12. "Enzymatic Catalysis By Alcohol Dehydrogenases in Organic Solvents": Jeffrey S.
`Deetz and J. David Rozzell; in Biocatalysts in Industry, Plenum Publishers (1990).
`13. "Nucleotide Sequence of a Cyclodextrin Glucosyltransferase Gene, cgtA, from
`Bacillus licheniformis": David E. Hill, Robert Aldape, and J. David Rozzell; Nucleic
`Acids Research, 18, 199 (1990).
`14. "Catalysis By Cofactor-Requiring Enzymes in Non-Aqueous Media": J. David
`Rozzell; in Industrial use of Enzymes: Technical and Economic Barriers, 167-92,
`Bernard Wolnak & Associates (1990).
`15. "Pathway for the Metabolism of Terephthalic Acid By Pseudomonas": Mark E.
`Ruppen and J. David Rozzell; Proceedings of the 5th European Congress on
`Biotechnology (1990).
`16. "Metabolic Pathway Engineering for the Production of New Chemicals": Peter
`Maxwell, Marcio Voloch, Jack Lynch, and J. David Rozzell; Proceedings of the 5th
`European Congress on Biotechnology (1990).
`
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`17. "The Production of Amino Acids by Transamination": J. David Rozzell; in
`Biocatalytic Production of Amino Acids and Derivatives: New Developments and
`Process Considerations, Hanser Publishers (1992).
`18. "Immobilization of Enzymes: Techniques and Applications": in Biocatalytic
`Production of Amino Acids and Derivatives: New Developments and Process
`Considerations, Hanser Publishers (1992).
`19. " Protein Structure Prediction": Benner Steven A., Gerloff Dietlind L., and Rozzell,
`Jr. James D.; Science 274, 1448-1449 (1996).
`20. "Synthesis of Oligonucleotides Containing 2'-Deoxyisoguanosine and 2'-Deoxy-5-
`methylisocytidine using Phosphoramidite Chemistry": Thomas R. Battersby, Simona
`C. Jurczyk, Janos T. Kodra, J. David Rozzell, and Steven A. Benner; Helvetica
`Chem. Acta, 81, 793-811 (1998).
`21. “Commercial Scale Biocatalysis: Legends, Myths and a Dose of Reality”: J. David
`Rozzell; Chiral Europe Proceedings, (1998).
`22. “Industrial-Scale Biocatalysis”: J. David Rozzell; in Bio-Organic and Medicinal
`Chemistry, (1999).
`23. “Visualization of Enzyme-Catalyzed Reactions Using pH Indicators: Rapid
`Screening of Hydrolase Libraries and Estimation of the Enantioselectivity”:
`Francisco Morís-Varas, Amit Shah, John Aikens, Neelesh P. Nadkarni, J. David
`Rozzell, and David Demirjian; Bio-Organic and Medicinal Chemistry, (1999).
`24. Tewari, Y. B., R. N. Goldberg and J. D. Rozzell, "Thermodynamics of reactions
`catalyzed by branched-chain-amino-acid transaminase," J. Chem. Thermodyn. 32
`(2000) 1381-398.
`25. Rozzell, J. D., Bommarius, A. S. (2002) Transamination, in: Enzyme Catalysis on
`Organic Synthesis (Drauz, K., Waldmann, H., eds), pp. 875-893, Wiley-VCH.
`26. “Chemo-Enzymatic Method for the Synthesis of Statine, Phenylstatine and Analogues”:
`Spiros Kambourakis and J. David Rozzell; Advanced Synthesis and Catalysis, 345, 699-
`705 (2003).
`27. Tewari, Y. B., D. J. Vanderah and J. D. Rozzell, "Thermodynamics of the lipase-
`catalyzed transesterification of 1-phenyl-1-alkanols and butyl acetate in organic
`solvents.” J. Mol. Catal. B: Enzymatic, 21 (2003) 123-131.
`28. “Ketoreductases in the synthesis of valuable chiral intermediates: application in the
`synthesis of alpha-hydroxy-beta-amino and beta-hydroxy-gamma-amino acids”:
`Spiros Kambourakis and J. David Rozzell; Tetrahedron, 60, 663-669 (2004).”
`29. Ketoreductases: stereoselective catalysts for the facile synthesis of chiral alcohols”
`Iwona A. Kaluzna, J. David Rozzell and Spiros Kambourakis, Tet. Asymm. (2005)
`16, 3682-3689.
`30. Zhu, D.; Rios, B. E.; Rozzell, J. D.; Hua, L. "Evaluation of substituent effects on activity and
`enantioselectivity in the enzymatic reduction of aryl ketones", Tetrahedron: Asymmetry,
`2005, 16, 1541-1546.
`31. Dunming Zhu, Chandrani Mukherjee, J. David Rozzell, Spiros Kambourakis and Ling Hua,
`“A recombinant ketoreductase tool-box. Assessing the substrate selectivity and
`stereoselectivity toward the reduction of ß-ketoesters.” Tetrahedron 61 (2005) 1–6.
`
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`32. Dimitris Kalaitzakis, J. David Rozzell,Spiros Kambourakis,and Ioulia Smonou, “Highly
`Stereoselective Reductions of alpha-Alkyl-1,3-diketones and r-Alkyl--Ketoesters Catalyzed
`by Isolated NADPH-Dependent Ketoreductases” Org. Lett. (2005) 7, 4799-4801.
`33. “A Thermodynamic Study of the ketoreductase-catalyzed reduction of 2-alkanones in non-
`aqueous solvents.” Y. B. Tewari, M. M. Schantz, K. W. Phinney, and J. D. Rozzell, J.
`Chem. Thermodynamics 37, 89-96 (2005).
`34. Tewari, Y.B., M.M. Schantz, K.W. Phinney and J.D. Rozzell, “A thermodynamic
`study of the ketoreductase-catalyzed reduction of 2-alkanones in non-aqueous
`solvents.” J. Chem. Thermodyn. 37 (2005) 89-96.
`35. Tewari,Y.B., N. Kishore, J.D. Rozzell, D.J. Vanderah and M.M. Schantz, "A
`thermodynamic study of ketoreductase-catalyzed reactions.3. Reduction of 1-
`phenyl-1-alkanones in non-aqueous solvents." J. Chem. Thermodyn. 38 (2006)
`1165-1171.
`36. Dimitris Kalaitzakis, J. David Rozzell, Ioulia Smonou, and Spiros Kambourakis,
`“Synthesis of Valuable Chiral Intermediates by Isolated Ketoreductases :
`Application in the Synthesis of a-Alkyl-ß-hydroxy Ketones and 1,3-Diols.” Adv.
`Synthesis and Catalysis (2006) 348, 1958-1969.
`37. Dimitris Kalaitzakis,[a] J. David Rozzell, Spiros Kambourakis,[b] and Ioulia Smonou
`“A Two-Step Chemoenzymatic Synthesis of the Natural Pheromone (+)-Sitophilure
`Utilizing Isolated, NADPH-Dependent Ketoreductases” Eur. J. Biochem., (2006)
`2309-2313.
`38. Spiros Kambourakis and J. David Rozzell, “Ketoreductases: General stereoselective
`catalysts for the facile synthesis of a broad range of chiral alcohols.” PharmaChem,
`September 2006, 2-5.
`39. Kavitha Vedha-Peters, Manjula Gunawardana, J. David Rozzell, and Scott J. Novick
`“Creation of a Broad-Range and Highly Stereoselective D-Amino Acid
`Dehydrogenase for the One-Step Synthesis of D-Amino Acids” J. Am. Chem. Soc.
`(2006) 128, 10923-10929.
`40. Tewari, Y.B., J.F. Liebman, J. D. Rozzell, D.J. Vanderah and M.M. Schantz, “A
`thermodynamic study of ketoreductase-catalyzed reactions. 4. Reduction of 2-
`substituted cyclohexanones in n-hexane.” J. Chem. Thermodyn. 39 (2007) 1090–
`1097.
`41. Dimitris Kalaitzakis, Spiros Kambourakis, J. David Rozzell and Ioulia Smonou
`“Stereoselective chemoenzymatic synthesis of sitophilate: a natural pheromone”
`Tet. Asymm. (2007) 18, 2418-2426.
`42. Tewari, Y.B., D.J. Vanderah, M.M. Schantz, R.N. Goldberg, J.D. Rozzell, J.F.
`Liebman, R.W. Hui, Y. Nissenbaum, and A.R. Parniani, “A thermodynamic study of
`ketoreductase-catalyzed reactions. 5. Reduction of substituted ketones in n-
`hexane.” J. Chem. Thermodyn. 39 (2008).
`43. David Rozzell and Jack Liang, “Enzymatic Production of the Key Montelukast
`Intermediate.” Specialty Chemicals, April 2008 Issue, 36-37.
`44. David Rozzell, “Hydroxylation Reactions with P450 Enzymes.” Sp2 Magazine, May
`2008 Issue, 28-29.
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`45. David Rozzell, “Bringing Biocatalysis into the Mainstream.” Sp2 Magazine,
`September 2008 Issue, 30-32.
`46. David Rozzell and Susan Lato, “Greener Chemical Processes from Biocatalysis.”
`PharmaChem, October 2008, 2-3.
`47. D. Koszelewski, I. Landera, D. Clay, G.M. Guebitz, D. Rozzell, and W. Kroutil,
`“Formal Asymmetric Biocatalytics Reductive Amination.” Angew. Chem. Int. Ed. 47,
`9337 –9340 (2008).
`48. Wenying Li and David Rozzell, “Biosynthesis of Drug Metabolites.” in “Biocatalysis
`for the Pharmaceutical Industry” Dr. Junhua Tao, Prof. Guoqiang Lin, Prof. Andreas
`Liese, Eds., John Wiley and Sons, New York, 2009.
`49. Roland Weis, Margit Winkler, Matthias Schittmayer, Spiros Kambourakis, Mandy Vink,
`J. David Rozzell, Anton Glieder, “A Diversified Library of Bacterial and Fungal
`Bifunctional Cytochrome P450 Enzymes for Drug Metabolite Synthesis.” Adv.
`Synthesis & Catalysis (2009), 351, 2140-2146.
`50. Matthew D. Truppo, Nicholas J. Turner, J. David Rozzell, “Efficient Kinetic Resolution of
`Racemic Amines Using a Transaminase in Combination with an Amino Acid Oxidase.”
`Chem. Comm. (2009) 2127-2129.
`51. Matthew D. Truppo, Nicholas J. Turner, J. David Rozzell, “Efficient Production of
`Enantiomerically Pure Chiral Amines at Concentrations of 50 g/L Using Transaminases”
`Org. Process Res. Dev., 2010, 14 (1), pp 234–237.
`52. Dimitri Dascier, Spiros Kambourakis, Ling Hua, J. David Rozzell, and Jon D. Stewart
`“Influence of Cofactor Regeneration Strategies on Preparative-Scale, Asymmetric Carbonyl
`Reductions by Engineered Escherichia coli” Org. Process Res. Dev. 2014, 18(6), 793-800.
`53. David Rozzell and Ryan Lauchli, “Enzyme Sources and Selection of Biocatalysts” in
`“Science of Synthesis Reference Library: Biocatalysis in Organic Synthesis,” Prof. K Faber,
`Prof. W-D. Fessner, and Prof. N. J. Turner, editors, Georg Thieme Verlag, Stuttgart, 2014.
`54. Thomas S. Moody and J. David Rozzell, “Modern Biocatalytic Ketone Reduction” in
`“Organic Synthesis Using Biocatalysis,” in press, Animesh Goswami and Jon D, Stewart,
`editors, Elsevier, Amsterdam, 2016.
`
`
`
`Books
`Editor of book "Biocatalytic Production of Amino Acids and Derivatives," Hanser
`Publishers, Munich, 1992.
`
`“Enzyme Sources Guide” published by Sustainable Chemistry Solutions, Inc., Burbank,
`2014.
`
`“Enzyme Company Guide” published by Sustainable Chemistry Solutions, Inc., Burbank,
`2015.
`
`“Biocatalysis Company Guide” published by Sustainable Chemistry Solutions, Inc.,
`Burbank, 2015.
`
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`
`Patents
`1. US 4,518,692: The Production of L-Amino Acids By Transamination (1985).
`2. US 4,525,454: The Production of L-4-Phenyl-2-Aminobutanoic Acid By Transamination
`(1985).
`3. US 4,826,766: Alpha Amino Acids From Alpha-Ketoacids Using Coupled Transaminase
`Enzymes (1989).
`4. US 4,880,738: Production of Amino Acids Using Coupled Enzyme Systems (1989).
`5. US 4,921,796: Immobilized Cyclodextrin Glucosyltransferase Composition for the
`Production of Cyclodextrins (1990).
`6. US 5,019,509: Method and Composition for the Production of L-Alanine and Derivatives
`Thereof (1990).
`7. US 5,169,780: Enantiomeric Enrichment and Stereoselective Synthesis of Chiral Amines
`(1992).
`8. US 5,834,261: Method for the Production of Chiral Vicinal Aminoalcohols (1998).
`9. US 5,885,767: Methods and Compositions for Qyuantitating L-Homocysteine and/or L-
`Methionine in a Solution (1999).
`10. US 5,916,786: Method for the Production of Chiral 1,3-Aminoalcohols (1999).
`11. US 5,942,644: Precursors for the Production of Chiral Vicinal Aminoalcohols (1999).
`12. US 6,207,862: Precursors for the Production of Chiral 1,3-Aminoalcohols (2001).
`13. US 6,366,860: Synthetic Genes for Enhanced Expression (2002).
`14. US 6,818,752: Synthetic Genes for Enhanced Expression (2004).
`15. US 6,822,116: Method for Producing D-allo-Isoleucine (2004).
`16. US 6,830,904: Method for Producing Diastereomers of Isoleucine (2004).
`17. US 6,833,471: Methods for Producing Hydroxy Amino Acids and Derivatives Thereof
`(2004).
`18. US 6,835,212: Agent and Method for Dyeing Keratin Fibers (2004).
`19. US 7,081,535: Hydroxy-Amino Acids (2006).
`20. US 7,156,884: Compositions and Methods for Dyeing Keratinous Fibers (2007).
`21. US 7,202,070: Method for the Reductive Amination of a Ketone Using a Mutated Enzyme
`(2007).
`22. US 7,301,031: Methods for Producing Hydroxy Amino Acids, Esters, and Derivatives
`Thereof (2007).
`23. US 7,550,277: D-Amino Acid Dehydrogenase and Method of Making D-Amino Acids
`(2009).
`24. US 7,642,073: Method for Reductive Amination of a Ketone Using a Mutated Enzyme
`(2010).
`
`Various Patent Applications Pending
`
`
`Research Support
`SBIR AI45241: Production of Non-Naturally Occurring Amino Acids; Phase 1 and 2;
`March 1999- Feb. 2002. PI. Development of novel methods to produce single
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`enantiomers of non-naturally occurring amino acids using transaminase enzymes that
`are newly discovered or created by directed evolution.
`
`SBIR GM65675: Novel Enzymatic Reductive Amination; Phase 1; May 2002-Dec 2002.
`PI. Creation new enzymes for reductive amination of ketones by laboratory enzyme
`evolution and high-throughput screening.
`
`SBIR GM59541: Salt-Activated Enzymes for Organic Synthesis; Phase 1; April 1999-
`Sept. 1999. PI. Evaluation of a novel method of salt-immobilization to activate enzymes
`for use in organic solvents.
`
`SBIR DK55951: Method for Neonatal Screening for Homocystinuria; Phase 1 and 2;
`Sept. 1999-Jan. 2003. PI. Development of an enzyme-based method to quantitate
`homocysteine in blood or urine samples of newborns.
`
`SBIR GM60822: Production of Chiral Aminoalcohols; Phase 1 and 2; Jan. 2000-Aug.
`2003. PI. Development of a novel chemo-enzymatic method for the production of single
`diastereomers of chiral amino alcohols for use as pharmaceutical intermediates.
`
`SBIR GM067536: Evolving Improved Formate Dehydrogenases: Phase 2: Sept. 2004-
`Aug. 2006. PI. Creation of new formate dehydrogenase enzymes having improved rate,
`stability, and activity on NADP+ as well as NAD+. Applications are for the recycle of
`nicotinamide cofactors in the synthesis of chiral compounds through redox processes.
`
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