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`Fluorescence characteristics and pharmacokinetic
`properties of a novel self-adhesive 5-ALA patch for
`photodynamic therapyof actinic keratoses.
`
`Fauteck JD", AckermannG,Birkel M, Breuer M, Moor AC,Ebeling A, Ortland C
`
`Author information >
`
`Archives of Dermatological Research, 25 Oct 2007, 300(2) 53-60
`DOI: 10.1007/s00403-007-0787-0
`PMID: 17960406
`
`Sharethis article
`
`vy Of
`
`Abstract
`
`Actinic keratosis (AK) can be treated by photodynamic therapy (PDT), which is becoming a well-established toolin
`dermatology. Normally a precursor of the photosensitiser is applied topically and converted into protoporphyrin IX
`(PPIX) in thecells. By activating PPIX with light, the dysplastic cells will be destroyed. We report the results of two
`clinical studies investigating the properties of a novel self-adhesive 5-ALA-patch (PD P 506 A) intended for PDT of m
`to moderate AK on the face and head. The studies investigated the influence of patch application duration on PPIX-
`specific fluorescence and the pharmacokinetic properties of the 5-ALA patch. The PPIX fluorescencein AK lesions a
`normal skin after patch application (intraindividual comparison; applicationfor 2, 3, 4, 5 h) was investigated in 13
`patients using DYADERM Professional (Biocam). In the subsequent pharmacokinetic study 12 patients were treated
`with 8 patches each (4 h application). 5-ALA and PPIX were analysed in plasma (over 24 h) and urine (over 12 h). PPI
`specific fluorescence measured immediately after patch removal increased with increasing application duration to
`maximumat 4-h application. The fluorescence in AK lesions was moreintense than in normal skin. A small increase
`of 5-ALA plasma concentrations was observed in 10 of 12 patients after applying 8 patches for 4 h, which rapidly
`declined to normalvalues after patch removal. The maximum increase was3.7-fold of the pre-dose 5-ALA plasma
`concentration. No PPIX-concentrations abovethe lowerlimit of quantification were observed. PPIX-specific
`fluorescencein AK lesions can be steered by application duration of this novel 5-ALA patch. Application is safe and
`well tolerable. The observed small rise in 5-ALA plasma concentrationsis regardedclinically irrelevant. Clinical
`efficacy of the patch in PDTwill be investigated in further clinicaltrials.
`
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`CITES:17960406_MED
`
`Coronavirus articles and preprints Search examples: "breast cancer" Smith]
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`
`Fluorescence characteristics and pharmacokinetic
`properties of a novel self-adhesive 5-ALA patch for
`photodynamic therapyof actinic keratoses.
`
`Fauteck JD", AckermannG,Birkel M, Breuer M, Moor AC,Ebeling A, Ortland C
`
`Author information >
`
`Archives of Dermatological Research, 25 Oct 2007, 300(2) 53-60
`DOI: 10.1007/s00403-007-0787-0
`PMID: 17960406
`
`Sharethisarticle
`
`vy Of
`
`Abstract
`
`Actinic keratosis (AK) can be treated by photodynamic therapy (PDT), which is becoming a well-established toolin
`dermatology. Normally a precursor of the photosensitiser is applied topically and converted into protoporphyrin IX
`(PPIX) in thecells. By activating PPIX with light, the dysplastic cells will be destroyed. We report the results of two
`clinical studies investigating the properties of a novel self-adhesive 5-ALA-patch (PD P 506 A) intended for PDT of m
`to moderate AK on the face and head. The studies investigated the influence of patch application duration on PPIX-
`specific fluorescence and the pharmacokinetic properties of the 5-ALA patch. The PPIX fluorescencein AK lesions a
`normal skin after patch application (intraindividual comparison; applicationfor 2, 3, 4, 5 h) was investigated in 13
`patients using DYADERM Professional (Biocam). In the subsequent pharmacokinetic study 12 patients were treated
`with 8 patches each(4 h application). 5-ALA and PPIX were analysed in plasma (over 24 h) and urine (over 12 h). PPI
`specific fluorescence measured immediately after patch removal increased with increasing application duration to
`maximumat 4-h application. The fluorescence in AK lesions was moreintense than in normal skin. A small increase
`of 5-ALA plasma concentrations was observed in 10 of 12 patients after applying 8 patches for 4 h, which rapidly
`declined to normalvalues after patch removal. The maximum increase was3.7-fold of the pre-dose 5-ALA plasma
`concentration. No PPIX-concentrations above the lowerlimit of quantification were observed. PPIX-specific
`fluorescencein AK lesions can be steered by application duration of this novel 5-ALA patch. Application is safe and
`well tolerable. The observed small rise in 5-ALA plasma concentrationsis regarded clinically irrelevant. Clinical
`efficacy of the patch in PDTwill be investigated in furtherclinicaltrials.
`
`Full text links
`
`References
`
`Citations & impact
`
`Impact metrics
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`Smartphonefluorescence imagerfor quantitative dosimetry of protoporphyrin-IX-based
`photodynamic therapyin skin.
`Ruiz AJ, LaRochelle EPM, GunnJR, Hull SM, Hasan T, Chapman MS, Pogue BW
`J Biomed Opt, 25(6):1-13, 01 Dec 2019
`Cited by: 1 article | PMID: 31820594 | PMCID: PMC6901011
`Free to read & use
`
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`Photodynamic therapy simplified: nonprepared, moderate-grade actinic keratosis lesions respond
`equally well to 5-aminolaevulinic acid patch photodynamic therapy as do mild lesions.
`Szeimies RM, Hauschild A, Ortland C, Moor AC, Stocker M, Surber C
`Br J Dermatol, 173(5):1277-1279, 26 Aug 2015
`Cited by: 3 articles | PMID: 25940103
`
`PpIX fluorescence combined with auto-fluorescence is more accurate than PpIX fluorescence alone
`in fluorescence detection of non melanoma skin cancer an intra patient direct comparison study
`van der Beek N de Leeuw) Demmendal C Bjerring P Neumann HA
`Lasers Surg Med,44(4):271-276, 13 Dec 2011
`Cited by: 6 articles | PMID: 22170313
`
`New aspects in photodynamic therapyof actinic keratoses.
`Smits T, Moor AC
`J Phietarhein Etesnbiel B 96(3) 159 169 13 Jun 2009
`Cited by 5 articles | PMID 19592269
`Review”
`
`
`An overview of topical photodynamic therapyin dermatology.
`Ibbotson SH
`Photodiagnosis Photod
`
`lyn Ther, 7(1):16-23, 29 Dec 2009
`MID
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`Abstract
`Full text 7
`References
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`Smartphone fluorescence imager for quantitative dosimetry of protoporphyrin-|X-based photodynamic the
`in skin.
`
`Ruiz AJ, LaRochelle EPM, GunnJR, Hull SM, Hasan T, Chapman MS, Pogue BW
`J Biomed Opt, 25(6):1-13, 01 Dec 2019
`Cited by:1 article | PMID: 31820594 | PMCID: PMC6901011
`
`+ Add to export list Free to read &
`
`Photodynamic therapy simplified: nonprepared, moderate-grade actinic keratosis lesions respond equally '
`to 5-aminolaevulinic acid patch photodynamic therapy as do mild lesions.
`Szeimies RM, Hauschild A, Ortland C, Moor AC, Stocker M, Surber C
`Br J Dermatol, 173(5):1277-1279, 26 Aug 2015
`Cited by: 3 articles | PMID: 25940103
`+ Add to export list
`
`PpIX fluorescence combined with auto-fluorescence is more accurate than PpIX fluorescence alonein
`fluorescence detection of non-melanomaskin cancer: an intra-patient direct comparison study.
`van der Beek N, de Leeuw J, DemmendalC, Bjerring P, Neumann HA
`Lasers Surg Med, 44(4):271-276, 13 Dec 2011
`Cited by: 6 articles | PMID: 22170313
`+ Add to export list
`
`Anoverview of topical photodynamic therapy in dermatology.
`Ibbotson SH
`
`Photodiagnosis Photodyn Ther, 7(1):16-23, 29 Dec 2009
`Cited by: 17 articles | PMID: 20230989
`
`+ Add to export list Rev
`
`Long-term follow-up of photodynamic therapywith a self-adhesive 5-aminolaevulinic acid patch: 12 month
`data.
`
`Szeimies RM, Stockfleth E, Popp G, Borrosch F, Briining H, Dominicus R, Mensing H, Reinhold U, Reich K, Moor é
`Stocker M, Ortland C, Brunnert M, Hauschild A
`Br J Dermatol, 162(2):410-414, 30 Jun 2009
`Cited by:26 articles | PMID: 19804593
`+ Add to export list
`
`New aspects in photodynamic therapyof actinic keratoses.
`Smits T, Moor AC
`J Photochem PhotobiolB, 96(3):159-169, 13 Jun 2009
`Cited by: 5 articles | PMID: 19592269
`+ Add to export list
`
`Rev
`
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`https://europepmc.org/search?query=CITES%3A17960406_MED&page=1 &sortby=Date DESC
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`004
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`
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`Lasers Surg Med, 41(2):96-103, 01 Feb 2009
`Cited by: 21 articles | PMID: 19226578
`+ Add to export list
`
`Optimization of photodynamic therapy with a novel self-adhesive 5-aminolaevulinic acid patch: results of t
`randomized controlled phaseIII studies.
`Hauschild A, Stockfleth E, Popp G, Borrosch F, Briining H, Dominicus R, Mensing H, Reinhold U, Reich K, Moor A
`Stocker M, Ortland C, Brunnert M, Szeimies RM
`Br J Dermatol, 160(5):1066-1074, 16 Feb 2009
`Cited by: 39 articles | PMID: 19222455
`+ Add to export list
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`Effective photodynamic therapyofactinic keratoses on the head andface with a novel, self-adhesive 5-
`aminolaevulinic acid patch.
`Hauschild A, Popp G, Stockfleth E, Meyer KG, Imberger D, MohrP, Itschert G, Kaufmann R, NeuberK, Frambach
`Gollnick H, Brunnert M, Stocker M, Ortland C, KarrerS
`Exp Dermatol, 18(2):116-121, 17 Jul 2008
`Cited by: 21 articles | PMID: 18643849
`+ Add to export list
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