United States Patent (19)
`Say et al.
`
`54 ELECTROCHEMICAL ANALYTE
`75 Inventors: James Say, Alameda; Michael F.
`Tomasco, Cupertino, both of Calif.;
`Adam Heller, Austin, Tex.; Yoram
`Gal, Kibbutz Yagur, Israel; Behrad
`Aria, Alameda, Calif.; Ephraim Heller,
`Oakland, Calif.; Phillip John Plante,
`Sunnyvale, Calif.; Mark S. Vreeke
`Alameda Calif s
`s
`s
`73 Assignee: E. Heller & Company, Alameda, Calif.
`
`21 Appl. No.: 09/034,372
`22 Filed:
`Mar. 4, 1998
`7
`51) Int. Cl.' ........................................................ A61B 5/05
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`58 Field of Search ..................................... 600/306, 308,
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`s
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`(45) Date of Patent:
`
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`Primary Examiner-Cary O’Connor
`ASSistant Examiner Navin Natnithithadha
`Attorney, Agent, or Firm-Merchant & Gould P.C.
`y, Ag
`57
`ABSTRACT
`An electrochemical analyte Sensor formed using conductive
`traces on a Substrate can be used for determining and/or
`monitoring a level of analyte in in vitro or in Vivo analyte
`containing fluids. For example, an implantable Sensor may
`be used for the continuous or automatic monitoring of a level
`of an analyte, Such as glucose, lactate, or oxygen, in a
`patient. The electrochemical analyte Sensor includes a Sub
`Strate and conductive material disposed on the Substrate, the
`conductive material forming a working electrode. In Some
`Sensors, the conductive material is disposed in recessed
`channels formed in a Surface of the Sensor. An electron
`transfer agent and/or catalyst may be provided to facilitate
`the electrolysis of the analyte or of a Second compound
`whose level depends on the level of the analyte. A potential
`is formed between the working electrode and a reference
`electrode or counter/reference electrode and the resulting
`current is a function of the concentration of the analyte in the
`body fluid.
`
`29 Claims, 8 Drawing Sheets
`
`55
`- - - -
`85 -
`
`
`
`/
`-
`
`52
`
`O -
`
`o
`
`Y-50
`
`- 49
`
`Y-57
`
`Page 1 of 86
`
`

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`

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