O
`
`United States Patent (19)
`Lord et al.
`
`USOO5390671A
`
`11) Patent Number:
`45
`Date of Patent:
`
`5,390,671
`Feb. 21, 1995
`
`e A/ao
`
`no oooo so a spoo a soa e s as a soa a
`
`9.
`
`5,071,408 12/1991 Ahmed ................................ 606/108
`54, TRANSCUTANEOUS SENSOR INSERTION
`5,108,819 4/1992 Heller et al. .
`SET
`5,299,571 4/1994 Mostrototoro ...................... 128/637
`O
`75) Inventors: Peter C. Lord, Santa Clarita; William
`Primary Examiner-Lee S. Cohen
`P. Van Antwerp, Brentwood; John J.
`Assistant Examiner-Bria M. Greer
`Mastrototaro, Los Angeles; Paul S.
`Attorney, Agent, or Firm-Kelly Bauersfeld & Lowry
`Cheney, II, Beverly Hills; Nannette
`57
`ABSTRACT
`M. Schnabel, Valencia, all of Calif.
`An insertion set is provided for transcutaneous place
`73 Assignee: MiniMed Inc., Sylmar, Calif.
`ment of a sensor such as a glucose sensor at a selected
`site within the body of a patient. The insertion set com
`21 Appl. No.: 213,101
`prises a slotted insertion needle extending through a
`22 Filed:
`Mar. 15, 1994
`mounting base adapted for mounting onto the patient's
`51) Int. Cl6
`A61B5/05: A61 B 5/04
`skin. A flexible thin film sensor includes a proximal
`52 U.S.C. .................................... 18763s. 28.763,
`segment carried by the mounting base and defining
`(58) Field of S
`/64. 128/32:3: : conductive contacts adapted for electrical connection
`w
`to a suitable monitor, and a distal segment protruding
`128/632, 634, 642; 606/108, 129; Ei from the mounting base with sensor electrodes for
`transcutaneous placement. The proximal and distal seg
`ments of the sensor are linearly offset or misaligned,
`with the distal segment fitted within the insertion needle
`for transcutaneous sensor placement with the needle as
`the mounting base is pressed onto the patient's skin. The
`insertion needle can then be withdrawn to leave the
`sensor distal segment at the selected insertion position
`with the sensor electrodes in contact with patient blood
`or other extracellular fluid.
`23 Claims, 3 Drawing Sheets
`
`(56.
`
`References Cited
`U.S. PATENT DOCUMENTS
`3,399,674 9/1968 Pannier et al. .
`E. 3. Eil w w aal.". ,.
`ya
`is
`iSchell et al. .....................
`4,562,751 1/1986 Nason et al. .
`4,573,994 3/1986 Fischell et al. .
`4678,408 7/1987 Nason et al.
`4,685,903 8/1987 Cable et al. .
`4,953,552 9/1990 DeMarzo ............................ 204/403
`
`IO
`
`
`
`56
`
`32
`
`Exhibit 1035
`Abbott Diabetes Care Inc. v. Dexcom Inc.
`IPR2022-00918
`
`

`

`U.S. Patent
`
`Feb. 21, 1995
`
`Sheet 1 of 3
`
`5,390,671
`
`".
`
`56
`
`32
`
`
`
`
`
`
`
`
`
`
`
`24
`
`2 N séra
`
`-
`
`Ya YZ.Z 7
`
`&AUZ
`
`Exhibit 1035
`Abbott Diabetes Care Inc. v. Dexcom Inc.
`IPR2022-00918
`
`

`

`5,390,671
`
`
`
`56
`
`IO
`
`34
`
`N SY
`N 50 & &
`Ny?SAAA\\\\\\\N
`23. 26
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`& 29
`38
`
`FIG 6
`
`Exhibit 1035
`Abbott Diabetes Care Inc. v. Dexcom Inc.
`IPR2022-00918
`
`

`

`U.S. Patent
`
`Feb. 21, 1995
`
`Sheet 3 of 3
`
`5,390,671
`
`FIG 7
`
`
`
`
`
`32
`
`MONITOR
`
`2-44
`
`Exhibit 1035
`Abbott Diabetes Care Inc. v. Dexcom Inc.
`IPR2022-00918
`
`

`

`10
`
`25
`
`1.
`
`TRANSCUTANEOUS SENSOR INSERTION SET
`
`BACKGROUND OF THE INVENTION
`This invention relates generally to devices and meth
`ods for placing a sensor at a selected site within the
`body of a patient. More specifically, this invention re
`lates to an improved and relatively simple insertion set
`for quick and easy transcutaneous placement of a flexi
`ble thin film sensor of the type used, for example, to
`obtain periodic blood glucose readings.
`In recent years, a variety of electrochemical sensors
`have been developed for a range of applications, includ
`ing medical applications for detecting and/or quantify
`ing specific agents in a patient's blood. As one example,
`15
`glucose sensors have been developed for use in obtain
`ing an indication of blood glucose levels in a diabetic
`patient. Such readings can be especially useful in moni
`toring and/or adjusting a treatment regimen which
`typically includes regular administration of insulin to
`20
`the patient. In this regard, blood glucose readings are
`particularly useful in conjunction with semiautomated
`medication infusion pumps of the external type, as gen
`erally described in U.S. Pat. Nos. 4,562,751; 4,678,408;
`and 4,685,903; or automated implantable medication
`infusion pumps, as generally described in U.S. Pat. No.
`4,573,994.
`Relatively small and flexible electrochemical sensors
`have been developed for subcutaneous placement of
`sensor electrodes in direct contact with patient blood or
`30
`other extracellular fluid, wherein such sensors can be
`used to obtain periodic readings over an extended per
`iod of time. In one form, flexible transcutaneous sensors
`are constructed in accordance with thin film mask tech
`niques wherein an elongated sensor includes thin film
`35
`conductive elements encased between flexible insulative
`layers of polyimide sheet or similar material. Such thin
`film sensors typically include exposed electrodes at a
`distal end for transcutaneous placement in direct
`contact with patient blood or the like, and exposed
`conductive contacts at an externally located proximal
`end for convenient electrical connection with a suitable
`monitor device. Such thin film sensors hold significant
`promise in patient monitoring applications, but unfortu
`nately have been difficult to place transcutaneously
`45
`with the sensor electrodes in direct contact with patient
`blood or other extracellular fluid.
`The present invention relates specifically to a sensor
`insertion set and related thin film sensor adapted for
`quickly and easily placing the sensor on a patient with
`50
`sensor electrodes in direct contact with patient blood or
`other extracellular fluid.
`SUMMARY OF THE INVENTION
`In accordance with the invention, a subcutaneous
`55
`insertion set is provided for placing a flexible sensor
`such as a thin film electrochemical sensor at a selected
`site within the body of a patient. The insertion set com
`prises a slotted insertion needle extending through a
`mounting base adapted for seated mounting onto the
`patient's skin. A flexible thin film sensor includes a
`proximal segment carried by the mounting base, and a
`distal segment protruding from the mounting base and
`having sensor electrodes thereon. The proximal and
`distal segments of the sensor are linearly offset or mis
`65
`aligned so that the distal segment can be fitted into the
`slotted insertion needle for transcutaneous placement as
`the mounting base is pressed onto the patient's skin. The
`
`5,390,671
`2
`insertion needle can be withdrawn from the mounting
`base, leaving the sensor distal segment at the selected
`position within the patient, such as a subcutaneous,
`intravascular, intramuscular, or intravenous site. Con
`ductive contacts on the sensor proximal end can be
`electrically connected to a suitable monitor device so
`that appropriate blood chemistry readings can be taken.
`In the preferred form, the sensor proximal and distal
`segments are formed generally in parallel offset relation,
`with a short transition segment extending angularly
`therebetween. The proximal segment is mounted on the
`mounting base in a position disposed generally parallel
`to the patient's skin, when the mounting base is seated
`upon the patient's skin. The transition segment of the
`sensor is angularly folded for reception of the sensor
`distal segment to a position generally coaxially within
`the slotted insertion needle. A retention member such as
`a bead of cured epoxy may be carried on the sensor
`distal segment to prevent lateral separation of the sensor
`from the insertion needle.
`The distal segment of the flexible sensor is transcu
`taneously placed as the insertion needle pierces the
`patient's skin upon press-on placement of the mounting
`base onto the patient's skin. The insertion needle can
`then be withdrawn from the patient and the mounting
`base. During such withdrawal, the insertion needle
`slides over the sensor distal segment, thereby leaving
`the sensor distal segment at the selected site.
`In one alternative preferred form of the invention, the
`retention member may comprise a length of tubing
`secured to the sensor distal segment and extending
`therefrom to an external position outside the patient.
`This tubing defines a small bore lumen which may be
`used subsequently to introduce medication to the pa
`tient or otherwise to introduce a selected sensor calibra
`tion fluid in the vicinity of the sensor electrodes for
`periodic sensor calibration functions.
`Other features and advantages of the present inven
`tion will become more apparent from the following
`detailed description, taken in conjunction with the ac
`companying drawings which illustrate, by way of ex
`ample, the principles of the invention.
`BRIEF DESCRIPTION OF THE DRAWINGS
`The accompanying drawings illustrate the invention.
`In such drawings:
`FIG. 1 is a perspective view illustrating a transcuta
`neous sensor insertion set embodying the novel features
`of the invention;
`FIG. 2 is an enlarged fragmented exploded perspec
`tive view illustrating assembly of portions of the trans
`cutaneous sensor insertion set of FIG. 1;
`FIG. 3 is an enlarged fragmented sectional view
`taken generally on the line 3-3 of FIG. 1;
`FIG. 4 is an enlarged fragmented perspective view
`showing slide-fit assembly of an insertion needle and
`flexible sensor of the sensor insertion set;
`FIG. 5 is an enlarged fragmented sectional view
`taken generally on the line 5-5 of FIG. 4;
`FIG. 6 is an enlarged fragmented sectional view
`taken generally on the line 6-6 of FIG. 1;
`FIG. 7 is a perspective view illustrating withdrawal
`of the insertion needle from the flexible sensor;
`FIG. 8 is a plan view illustrating an assembled inser
`tion needle and sensor embodying an alternative pre
`ferred form of the invention; and
`
`Exhibit 1035
`Abbott Diabetes Care Inc. v. Dexcom Inc.
`IPR2022-00918
`
`

`

`10
`
`5,390,671
`3
`4
`FIG. 9 is an enlarged sectional view taken generally
`rails 46 formed on the flexible pad. The proximal sensor
`on the line 9-9 of FIG. 8.
`segment 28 has a forwardmost end joined to the transi
`tion segment 26 folded angularly downwardly within a
`DETALED DESCRIPTION OF THE
`keyhole slot 48 formed in the flexible pad 38. That is, as
`PREFERRED EMBODIMENTS
`shown in FIG. 5, the keyhole slot 48 includes a narrow
`As shown in the exemplary drawings, an improved
`and relatively straight slit protruding radially from one
`sensor insertion set referred to generally in FIG. 1 by
`side of a circular aperture. The transition segment 26 of
`the reference numeral 10 is provided for transcutaneous
`the flexible sensor 12 folds angularly downwardly into
`placement of a flexible sensor 12 (FIG. 2) at a selected
`the slit and then extends laterally into the circular aper
`site within the body of a patient. The insertion set 10
`ture whereat the transition segment 26 isjoined with the
`includes a rigid hollow insertion needle 14 for quick and
`distal sensor segment 16. The keyhole slot 48 is shown
`easy transcutaneous placement of a sensor distal seg
`to extend angularly through the pad 38 at an angle of
`ment 16 having one or more exposed sensor electrodes
`about forty-five degrees, although it will be understood
`18 thereon. The insertion needle 14 is then withdraw
`that other angular orientations up to ninety degrees may
`able to leave the sensor electrodes 18 in place at the
`be used.
`15
`selected site.
`The insertion needle 14 is adapted for slide-fit recep
`The transcutaneous sensor insertion set 10 of the
`tion through a circular needle port 50 formed in the
`present invention is particularly designed for facilitating
`support plate 44, and further through the circular aper
`accurate placement of a flexible thin film electrochemi
`ture of the keyhole slot 48 in the flexible mounting pad
`cal sensor of the type used for monitoring specific blood
`38. As shown in FIGS. 1 and 2, the insertion needle 14
`20
`parameters representative of patient condition. The
`has a sharpened tip 52 and an open narrow slot 54 which
`insertion set 10 is designed to place the sensor subcuta
`extends longitudinally from the tip 52 along one side of
`neously or at another selected site within the body of a
`the needle to a position at or near a hub 56 at the rear
`patient, in a manner minimizing patient discomfort and
`end thereof. The insertion needle 14 fits through the
`trauma. In one preferred application, the sensor 12 may
`support plate 44 and keyhole slot 48 of the mounting
`25
`be designed to monitor blood glucose levels, and may
`base 34, with the needle slot 54 laterally facing the
`be used in conjunction with automated or semiauto
`straight slit portion of the keyhole slot 48. With this
`mated medication infusion pumps of the external or
`arrangement, as shown in FIGS. 4 and 6, the transition
`implantable type as described in U.S. Pat. Nos.
`segment 26 between the sensor distal and proximal seg
`4,562,751; 4,678,408; 4,685,903 or 4,573,994, to deliver
`ments 16 and 28 projects laterally through the needle
`insulin to a diabetic patient.
`slot 54 so that the sensor distal segment is coaxially
`As shown best in FIGS. 2 and 3, the flexible electro
`aligned within the insertion needle 14, but linearly mis
`chemical sensor 12 is constructed according to so-called
`aligned or offset with respect to the sensor proximal
`thin film mask techniques to include elongated thin film
`segment 28.
`conductors 20 embedded or encased between upper and
`In use, the insertion set 10 permits quick and easy
`35
`lower layers 22 and 24 of a selected insulative material
`transcutaneous placement of the sensor distal segment
`such as polyimide film or sheet. The sensor electrodes
`16 at a selected site within the body of the patient. More
`18 at a tip end of the distal segment 16 are exposed
`specifically, the peel-off strip 42 (FIG. 1) is removed
`through the upper layer 22 for direct contact with pa
`from the pad 38, at which time the mounting base 34 can
`tient blood, when the sensor is transcutaneously placed.
`be pressed onto and seated upon the patient's skin. Dur
`The distal segment 16 is joined by an angularly extend
`ing this step, the insertion needle 14 pierces the patient's
`ing or offset transition segment 26 to a proximal seg
`skin 36 (FIG. 6) and carries the sensor distal segment 16
`ment 28, the end of which terminates in conductive
`therein to the appropriate transcutaneous placement
`contact pads 30 which are also exposed through the
`site. A retention member 58 such as a cured bead of
`upper insulative layer 22. As is known in the art, and
`epoxy or the like may be placed on the sensor distal
`45
`illustrated schematically in FIG. 1, these contact pads
`segment 16, at one or more positions along the length
`30 are adapted for electrical connection to a suitable
`thereof, to prevent inadvertent lateral separation of the
`monitor 32 for monitoring patient condition in response
`sensor distal segment from the insertion needle. In this
`to signals derived from the sensor electrodes 18. Fur
`regard, the retention member 58 in combination with
`ther description of flexible thin film sensors of this gen
`the thickness of the sensor 12, provides a dimension
`SO
`eral type may be formed in copending U.S. Serial No.
`greater than the width of the needle slot 54, thereby
`(MiniMed Docket MT-0222), filed concurrently here
`preventing sideways separation of the sensor through
`with, (Docket 34279), entitled METHOD OF FABRI
`the needle slot (FIG. 3).
`CATING THIN FILM SENSORS, which is incorpo
`When the sensor is transcutaneously placed, with the
`rated by reference herein.
`mounting base 34 seated upon the patient's skin, the
`55
`The sensor 12 is carried by a mounting base 34
`insertion needle 14 can be withdrawn from the patient.
`adapted for placement onto the skin 36 (FIG. 6) of a
`During this withdrawal step, as illustrated in FIG. 7, the
`patient. As shown, the mounting base 34 comprises an
`insertion needle 14 slides over the sensor distal segment
`enlarged and generally rectangular flexible foam pad 38
`16, leaving the sensor electrodes 18 at the selected inser
`having an underside surface coated with a suitable pres
`tion site. The conductive contact pads 30 on the sensor
`sure sensitive adhesive 40 (FIG. 1). A peel-off paper
`proximal segment 28 are appropriately coupled to the
`strip 42 is normally provided to cover and protect the
`monitor 32, so that the sensor 12 can then be used over
`adhesive layer 40, until the insertion set 10 is ready for
`a prolonged period of time for taking blood chemistry
`readings, such as blood glucose readings in a diabetic
`Se.
`As shown in FIGS. 4 and 5, the proximal segment 28
`patient.
`65
`of the flexible sensor 12 is sandwiched between the
`FIGS. 8 and 9 show one alternative preferred em
`flexible pad 38 and an overlying support plate 44 which
`bodiment of the invention, wherein a modified retention
`may be conveniently positioned between upstanding
`member 158 is provided in the form of a length of flexi
`
`30
`
`Exhibit 1035
`Abbott Diabetes Care Inc. v. Dexcom Inc.
`IPR2022-00918
`
`

`

`O
`
`15
`
`5,390,671
`5
`6
`ble tubing attached to the sensor 12. This tubing 158
`9. The transcutaneous sensor insertion set of claim 1
`extends through the insertion needle to a point outside
`wherein said insertion needle has a sharp tip and a rear
`the body of the patient, as by following the contour of
`end with a hub mounted thereon to facilitate manual
`the flexible sensor along the transition and proximal
`withdrawal of said needle from said mounting base and
`segments 26 and 28. The tubing 158 provides a conve
`said sensor distal segment.
`nient transcutaneous lumen for administration of medi
`10. The transcutaneous sensor insertion set of claim 1
`cation to the patient, as desired. Alternatively, the tub
`wherein said insertion needle extends through an open
`ing 158 defines a path through which a selected calibra
`port formed in said mounting base, in generally coaxial
`tion fluid can be administered to the patient, at a loca
`alignment with said sensor distal segment for slide-fit
`tion directly proximate to the sensor electrodes 18. In
`reception of said sensor distal segment within said nee
`this regard, when the sensor electrodes are designed for
`dle, said insertion needle being positioned to pierce a
`obtaining periodic glucose level readings, occasional
`patient's skin to carry said sensor distal segment to an
`recalibration of those electrodes may be necessary or
`insertion position within the patient upon placement of
`desirable to ensure accurate blood glucose readings.
`said mounting base onto the patient's skin, said insertion
`The transcutaneous sensor insertion set of the present
`needle being slidably withdrawable from the patient's
`invention thus provides a relatively simple device for
`skin and said mounting base to leave said sensor distal
`quickly and easily placing a flexible thin film electro
`segment at the insertion position.
`chemical sensor at a selected position within a patient.
`11. The transcutaneous sensor insertion set of claim 1
`The slotted insertion needle permits use of a relatively
`wherein said sensor proximal segment includes at least
`narrow gage needle, thereby minimizing patient trauma
`one exposed conductive contact.
`20
`and related discomfort.
`12. The transcutaneous sensor insertion set of claim 1
`A variety of modifications and improvements to the
`wherein said mounting base includes means for remov
`transubcutaneous sensor insertion set of the present
`able attachment thereof to the patient's skin.
`invention will be apparent to those skilled in the art.
`13. A transcutaneous sensor insertion set, comprising:
`Accordingly, no limitation on the invention is intended
`a mounting base adapted for placement onto a pa
`25
`by way of the foregoing description and accompanying
`tient's skin;
`drawings, except as set forth in the appended claims.
`a flexible sensor having a proximal segment carried
`What is claimed is:
`by said mounting base, a distal segment protruding
`1. A transcutaneous sensor insertion set, comprising:
`downwardly from said mounting base and having a
`a mounting base adapted for mounting onto a pa
`30
`tip end with at least one sensor electrode thereon,
`tient’s skin;
`and a transition segment interconnecting said prox
`a flexible sensor having a proximal segment carried
`imal and distal segments in axially misaligned rela
`by said mounting base, and a distal segment pro
`tion; and
`truding from said mounting base and having at least
`hollow insertion needle having a longitudinally
`one sensor electrode thereon, said proximal and
`elongated slot formed along one side thereof, said
`35
`distal segments being misaligned with respect to
`needle being slidably receivable through an open
`each other; and
`port formed in said mounting base in generally
`a hollow insertion needle carried by said mounting
`coaxial alignment with said sensor distal segment
`base to protrude therefrom and having said distal
`for slide-fit reception of said sensor distal segment
`segment of said sensor received therein, said inser
`within said needle, with said sensor transition seg
`tion needle defining a longitudinally extending slot
`ment extending through said needle slot;
`along one side thereof to permit sliding withdrawal
`said insertion needle being positioned to pierce a
`of said needle from said mounting base and said
`patient's skin to carry said sensor distal segment to
`distal segment of said sensor.
`an insertion position within the patient upon place
`2. The transcutaneous sensor insertion set of claim 1
`ment of said mounting base onto the patient's skin,
`45
`wherein said sensor further includes a transition seg
`said insertion needle being slidably withdrawable
`ment interconnecting said proximal and distal segments
`from the patient’s skin and said mounting base to
`in laterally offset relation, said transition segment ex
`leave said sensor distal segment at the insertion
`tending through said needle slot when said distal seg
`position.
`ment is received within said needle.
`50
`14. The transcutaneous sensor insertion set of claim
`3. The transcutaneous sensor insertion set of claim 1
`13 wherein said mounting base supports said sensor
`further including a retention member on said sensor
`proximal segment in angular relation to said sensor
`distal segment to prevent lateral displacement of said
`distal segment.
`sensor distal segment through said needle slot.
`15. The transcutaneous sensor insertion set of claim
`4. The transcutaneous sensor insertion set of claim 3
`13 further including a retention member on said sensor
`55
`wherein said retention member comprises a bead of
`distal segment to prevent lateral displacement of said
`cured epoxy.
`sensor distal segment through said needle slot.
`5. The transcutaneous sensor insertion set of claim 3
`16. The transcutaneous sensor insertion set of claim
`wherein said retention member comprises a length of
`15 wherein said retention member comprises a bead of
`tubing connected to said sensor distal segment and ex
`cured epoxy.
`60
`tending therefrom to a position outside the patient when
`17. The transcutaneous sensor insertion set of claim
`the sensor distal segment is transcutaneously placed.
`15 wherein said retention member comprises a length of
`6. The transcutaneous sensor insertion set of claim 1
`tubing connected to said sensor distal segment and ex
`wherein said sensor is a flexible thin film sensor.
`tending therefrom to a position outside the patient when
`7. The transcutaneous sensor insertion set of claim 1
`the sensor distal segment is transcutaneously placed,
`wherein said sensor is an electrochemical sensor.
`said tubing defining a transcutaneous fluid flow path for
`8. The transcutaneous sensor insertion set of claim 1
`selectively delivering fluid to and from a position proxi
`wherein said sensor is a glucose sensor.
`mate to said sensor electrode.
`
`65
`
`Exhibit 1035
`Abbott Diabetes Care Inc. v. Dexcom Inc.
`IPR2022-00918
`
`

`

`ck
`
`xe
`
`k
`
`5,390,671
`7
`8
`18. The transcutaneous sensor insertion set of claim
`proximal segment to extend through a port formed in
`said pad.
`13 wherein said sensor is a flexible thin film sensor.
`19. The transcutaneous sensor insertion set of claim
`22. The transcutaneous sensor insertion set of claim
`21 wherein said port formed in said pad has a generally
`13 wherein said sensor proximal segment includes at
`keyhole shape defining a relatively straight slit extend
`least one exposed conductive contact.
`ing radially from a generally circular aperture, said
`20. A transcutaneous sensor insertion set, comprising:
`sensor transition segment being folded to extend from
`a flexible sensor having a proximal segment with at
`said proximal segment through said straight slit to said
`least one conductive contact, a distal segment with
`distal segment at a position within said circular aper
`at least one sensor electrode, a transition segment
`10
`ture.
`interconnecting said proximal and distal segments
`23. The transcutaneous sensor insertion set of claim
`in axially misaligned relation, and at least one con
`22 further including a hollow insertion needle having a
`ductor extending within said sensor from said con
`longitudinally extending slot formed in one side thereof,
`ductive contact to said sensor electrode; and
`said needle being slidably receivable through said circu
`a mounting base adapted for placement onto a pa
`lar aperture for slide-fit reception of said sensor distal
`15
`segment therein, with said sensor transition segment
`tient's skin, said mounting base including means for
`extending through said needle slot, said insertion needle
`Supporting said sensor proximal segment in a posi
`being positioned to pierce a patient's skin to carry said
`tion with said sensor distal segment protruding
`sensor distal segment to an insertion position within the
`downwardly from said mounting base.
`patient upon placement of said mounting base onto the
`20
`21. The transcutaneous sensor insertion set of claim
`patient's skin, said insertion needle being slidably with
`20 wherein said mounting base comprises a pad adapted
`drawable from the patient's skin and said mounting base
`for placement onto the patient's skin and having said
`to leave said sensor distal segment at the insertion posi
`sensor proximal segment carried thereon, said sensor
`tion.
`transition segment being folded relative to said sensor
`25
`
`k
`
`ck
`
`30
`
`35
`
`45
`
`50
`
`55
`
`65
`
`Exhibit 1035
`Abbott Diabetes Care Inc. v. Dexcom Inc.
`IPR2022-00918
`
`