October 11, 1996
`
`VOLUME271
`
`NUMBER 41
`
`ISSN 0021-9258
`JBCHAS3 271(41) 25059-25722 (1996)
`
`THE >
`ournalof
`Biological
`Chemistry
`
`Published by the American Society for Biochemistry
`and Molecular Biology
`
`FOUNDED BY CHRISTIAN A HERTER
`
`AND SUSTAINED IN PART BY THE CHRISTIAN A HERTER MEMORIAL FUND
`
`THE JOURNAL OF BIOLOGICAL CHEMISTRY IS AVAILABLE ON THE WORLD WIDE WEB
`
`http://www-jbc.stanford.edu/jbc/
`
`
`
`Page 1 of 12
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`BLUEBIRD EXHIBIT 1047
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`d
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`Page 1 of 12
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`BLUEBIRD EXHIBIT 1047
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`

`

`THE JOURNAL OF BIOLOGICAL CHEMISTRY
`
`FOUNDED BY CHRISTIAN A. HERTER AND SUSTAINED IN PART BY THE CHRISTIAN A. HERTER MEMORIAL FUND
`
`PUBLISHED BY THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY,INC.
`
`
`EDITORIAL BOARD/1996_
`
`|
`
`
`
`
`
`zi
`
`Ralph A. Bradshaw,Associate Editor
`John H. Exton, Associate Editor
`Alan G. Goodridge, Associate Editor
`Richard W. Hanson, Associate Editor
`Vincent C. Hascall, Associate Editor
`Robert L. Hill, Associate Editor
`Sherrill L. Adams
`Robert S. Adelstein
`Bharat Aggarwal
`Joseph P. Albanesi
`Norma M.Allewell
`Paul M. Anderson
`Vernon E. Anderson
`Ifeanyi J. Arinze
`Richard N. Armstrong
`Peter S. Aronson
`Thomas O.Baldwin
`Robert A. Bambara
`Leonard J. Banaszak
`Mariano Barbacid
`Heinz Baumann
`Joseph M. Beechem
`Vann Bennett
`Dale J. Benos
`Jeffrey L. Benovic
`NathanA. Berger
`Helen M. Berman
`David A. Bernlohr
`Maurice J. Bessman
`Bruce Beutler
`M.Motasim Billah
`Morris J. Birnbaum
`Mariel Birnbaumer
`Diana L.Blithe
`Stephen Bocckino
`Paul E. Bock
`James W. Bodley
`Irving Boime
`David Wayne Bolen
`William F. Bosron
`LawrenceF. Brass
`Richard G. Brennan
`Michael Brenowitz
`Keith Brew
`Robert J. Brooker
`Michael Brownstein
`Steven S. Broyles
`George J. Broze
`Henri Brunengraber
`Joseph Bryan
`Floyd R. Bryant
`Wlodzimierz M. Bujalowski
`Peter M. J. Burgers
`Barbara K. Burgess
`Raymond F. Burk
`John Burke
`Drusilla L. Burns
`Fernando R. Cabral
`Kevin P. Campbell
`John R. Cann
`Roderick A. Capaldi
`Don M.Carlson
`Gerald M. Carlson
`George M. Carman
`Graham Carpenter
`Patrick J. Casey
`Michael Cashel
`Francis J. Castellino
`Kevin J. Catt
`Richard A. Cerione
`Ta-Yuan Chang
`Moses V. Chao
`P. Boon Chock
`David T. Chuang
`Frank C. Church
`Frank Chytil
`Steven G. Clarke
`Dennis O. Clegg
`G. Marius Clore
`Melanie H. Cobb
`Jonathan B. Cohen
`
`Roger J. Colbran
`Joan. W. Conaway
`H. Edward Conrad
`J. D. Corbin
`Michael M. Cox
`Richard L. Cross
`Larry W.Daniel
`Douglas Dean
`Donald B. DeFranco
`Pieter L. de Haseth
`George N. DeMartino
`Pierre De Meyts
`Melvin L. DePamphilis
`AnnaA. DePaoli-Roach
`Channing J. Der
`Robert Deschenes
`Wolfgang H. Dillmann
`Vishva Dixit
`Steven K. Dower
`Kurt Drickamer
`Ronald Dubreuil
`Maria L. Dufau
`Richard L. Eckert
`Dale E. Edmondson
`Peter A. Edwards
`DuaneC.Eichler
`Betty A. Eipper
`Edward Eisenstein
`James Douglas Engel
`Harold P. Erickson
`Charles T. Esmon
`Peggy J. Farnham
`Alan P.Fields
`Robert H. Fillingame
`Richard A.Firtel
`David Fitzgerald
`Garret A. FitzGerald
`Michael D. Forgac
`Bernard G. Forget
`Claire M. Fraser
`Colin D. Funk
`JohnI. Gallin
`David L. Garbers
`Keith D. Garlid
`Lee Gehrke
`ThomasD. Gelehrter
`Sandra J. Gendler
`Craig Gerard
`Mary Jane Gething
`Jackson Gibbs
`Hiram F. Gilbert
`Henry N. Ginsberg
`Ann Ginsburg
`Tibor T. Glant
`David B. Glass
`Claiborne V. C. Glover III
`David V. Goeddel
`I. David Goldman
`Myron F. Goodman
`Joel M. Gottesfeld
`Daryl K. Granner
`Donald J. Graves
`Michael Green
`Sergio Grinstein
`Richard W. Gross
`Arthur R. Grossman
`Michael Grunstein
`Lorraine J. Gudas
`Richard I. Gumport
`Arthur L. Haas
`Joel F. Habener
`Margaret E. Haberland
`Stephen L. Hajduk
`Sen-itiroh Hakomori
`Joyce I. Hamlin
`
`Herbert Tabor, Editor
`Claudia Kent, Associate Editor
`I. Robert Lehman,Associate Editor
`Jerry B Lingrel, Associate Editor
`Kathleen S. Matthews, Associate Editor
`Kenneth E. Neet, Associate Editor
`Stephen M. Prescott, Associate Editor
`Heidi E. Hamm
`Ulf Lindahl
`Steve Hanks
`Vishwanath R. Lingappa
`Robert J. Linhardt
`Michael R. Hanley
`Robert A. Harris
`John D. Lipscomb
`Marietta L. Harrison
`Laura Liscum
`Gerald W. Hart
`Irving Listowsky
`Robert L. Heinrikson
`Mark 0.Lively
`Renu A.Heller
`Zvi Livneh
`Lawrence F. Loeb
`Susan A. Henry
`Brian Herman
`Joel Loftus
`Paul W. Ludden
`Harvey R. Herschman
`Richard F. Luduena
`John W.B. Hershey
`RussHille
`Donal S. Luse
`Samuel E. Lux
`Ole Hindsgaul
`Ian G, Macara
`Jay Hirsh
`Yaacov Hod
`Robert W. Mahley
`Robert S. Hodges
`Vince C. Manganiello
`Kenneth G. Mann
`Jeffrey M. Hoeg
`Sandra L. Hofmann
`David R. Manning
`. Paul Horowitz
`James M. Manning
`Kenneth J. Marians
`M.Marlene Hosey
`Daniel R. Marshak
`Billy G..Hudson
`Michael A. Marletta
`Richard L. Huganir
`Tony E. Hugli
`Nancy C. Martin
`John B. Imboden
`Marino Martinez-Carrion
`Thomas§. Ingebritsen
`Vincent Massey
`Bettie Sue Masters
`ThomasL. Innerarity
`Keizo Inoue
`Christopher K. Mathews
`Renato V. Iozzo
`Rafael Mattera
`Suzanne Jackowski
`Harry R. Matthews
`Steven J. Jacobs
`Richard E. McCarty
`Robert J. James
`Rodger P. McEver
`Michael L. Jennings
`G. Stanley McKnight
`Tae H. Ji
`Linda C. McPhail
`Eric F. Johnson
`Kathryn E. Meier
`Alfred H. Merrill
`Larry R. Jones
`Donald B. Jump
`Tobias Meyer
`Edith W. Miles
`Laurie S. Kaguni
`Edward Mocarski
`Jack H. Kaplan
`Keith Moffat
`Jerry Kaplan
`Neil Kaplowitz
`William T. Morgan
`Richard I. Morimoto
`Charles B. Kasper
`Howard R. Katz
`John S. Mort
`Yoshito Kaziro
`Glenn E. Mortimore
`Andrius Kazlauskas
`Dale W. Mosbaugh
`Joel Moss
`Robert G. Kemp
`Shmuel Muallem
`Daniel Klionsky
`Walter Kisiel
`Mike Mueckler
`Hynda K. Kleinman
`Marc C. Mumby
`Randall L. Kincaid
`Robert S. Munford
`Brian Kobilka
`Philip M. Murphy
`Richard Kolesnick
`Joanne Murphy-Ullrich
`John J. Kopchick
`Hideaki Nagasi
`Ron Rieger Kopito
`AngusC. Nairn
`Murray Korc
`Joseph L. Napoli
`Ruth M. Kramer
`William M. Nauseef
`Monty Krieger
`Benjamin G. Neel
`ThomasA. Kunkel
`Francis C. Neuhaus
`John M.Kyriakis
`Christopher B. Newgard
`Alexandra Newton
`Gary E, Landreth
`John C, Lawrence
`J. Wylie Nichols
`James C. Lee
`John H. Nilson
`Y. C. Lee
`Robert C. Nordlie
`Stuart F. Le Grice
`Peter Novick
`Mark A. Lehrman
`Thomas L. Nowak
`Warren J. Leonard
`Jerrold M. Olefsky
`Christina C. Leslie
`Joanna B. Olmsted
`Ellis R. Levin
`Bjorn R. Olsen
`Rodney L. Levine
`Bradley B. Olwin
`David E. Levy
`Jack H. Oppenheimer
`Charles P. Ordahl
`ThomasS. Leyh
`Neil Osheroff
`Stephen A. Liebhaber
`Gustav E. Lienhard
`Ida S. Owens
`ThomasM.Lincoln
`R. Padmanabhan
`
`Robert T. Schimke, Associate Editor
`Robert D. Simoni, Associate Editor
`James T. Stull, Associate Editor
`Thomas C. Vanaman,Associate Editor
`Kensal E. van Holde, Associate Editor
`Martha Vaughan, Associate Editor
`Keith L. Parker
`Jules A. Shafer
`Peter J. Parker
`Barry Shane
`J. Thomas Parsons
`Aaron J. Shatkin
`Sarah J. Parsons
`Stephen B. Shears
`Dennis Shields
`Nicola C. Partridge
`MulchandS.Patel
`Steven E. Shoelson
`Phillip H. Pekala
`Gary E. Shull
`John T. Penniston
`Howard A. Shuman
`Ernest G. Peralta
`David R. Sibley
`Anthony Persechini
`5. Stoney Simons,Jr.
`Anna Marie Skalka
`Jeffrey E, Pessin
`Kenneth D. Philipson
`Richard G. Sleight
`Paul F. Pilch
`Jeffrey W. Smith
`ThomasL. Poulos
`Martin D. Snider
`Susan Powers-Lee
`Roy J. Soberman
`William B. Pratt
`Avril V. Somlyo
`Jack Preiss
`Leonard D. Spicer
`David H. Price
`Robert G. Spiro
`Darwin J. Prockop
`Michael Sporn
`Richard L. Proia
`HowardSprecher
`John A. Putkey
`Linda L. Spremulli
`James P. Quigley
`John L. Spudich
`Daniel M. Raben
`Darrel W. Stafford
`Francesco Ramirez
`E. Richard Stanley
`A. Hari Reddi
`Pamela Stanley
`John C. Reed
`JamesV. Staros
`Marilyn D. Resh
`Robert E. Steele
`Donald F. Steiner
`Raymond Reeves
`Reinhart A. F. Reithmeier
`TomH. Stevens
`Robert E. Rhoads
`Jeffry B. Stock
`John P. Richardson
`Catherine D. Strader
`Paul D. Rick
`ThomasW.Sturgill
`A. Jennifer Rivett
`ThomasC. Siidhof
`Peter J. Roach
`Kathleen J. Sweadner
`Anita B. Roberts
`Ira Tabas
`David D. Roberts
`Marvin L. Tanzer
`James M.Roberts
`Palmer Taylor
`Diane M. Robins
`Simeon Taylor
`Janet D. Robishaw
`Elizabeth C. Theil
`ThomasE. Roche
`Dennis J. Thiele
`Charles O. Rock
`Andrew P. Thomas
`William J. Roesler
`Kenneth A. Thomas
`Barry P. Rosen
`Larry S. Tobacman
`Allan J. Tobin
`Jeffrey Ross
`Richard A. Roth
`Douglas M.Tollefsen
`Fritz M. Rottman
`Howard C, Towle
`James Travis
`Enrique Rozengurt
`Peter Rubenstein
`Robert B. Trimble
`Frederick B. Rudolph
`Bernard L. Trumpower
`Zaverio M. Ruggeri
`Kathleen M. Trybus
`David W.Russell
`Robert H. Tukey
`John C. Saari
`Salvatore J. Turco
`Lawrence E. Samelson
`Michael D. Uhler
`David Samols
`Todd A. Verdoorn
`Charles E. Samuel
`Joseph J. Villafranca
`Konrad Sandhoff
`Dennis R. Voelker
`ImmoE. Scheffler
`Charles J. Waechter
`Car] Schildkraut
`Donal A. Walsh
`Michael Schimerlik
`John L. Wang
`Bernard P. Schimmer
`Teresa S. F. Wang
`Christian Schindler
`David J. Waxman
`Joseph Schlessinger
`Paul H. Weigel
`Gregory W. Schmidt
`Peter Anthony Weil
`Vern L. Schramm
`Robert J. Wenthold
`Reed B. Wickner
`Robert D. Schreiber
`Arnold Schwartz
`Bryan R. G. Williams
`Martin A. Schwartz
`Masaki Yanagishita
`Robert Schwartz
`Helen L. Yin
`John D. Scott
`Howard A. Young
`Jere P. Segrest.
`Peter R. Young
`Pravin B. Sehgal
`Daniel M.Ziegler
`Michael E.Selsted
`Sally H. Zigmond
`Alan E, Senior
`Guy A. Zimmerman
`R. Suzanne Zukin
`David Ray Setzer
`
`John T. Edsall, Advisor to the Board
`Charles C. Hancock, Manager, 9650 Rockville Pike, Bethesda, Maryland 20814
`Barbara A. Gordon, Assistant to the Editor
`Page 2 of 12
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`Page 2 of 12
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`

`
`
`Vol. 271, No. 41
`
`The Journal of
`Biological Chemistry
`
`October 11, 1996
`
`Copyright © 1996 by the American Society for Biochemistry and Molecular Biology, Inc.
`9650 Rockville Pike, Bethesda, MD 20814 U.S.A.
`
`25059
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`25067
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`25107
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`25117
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`25126
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`25131
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`25145
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`25157
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`25173
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`25192
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`25198
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`25204
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`25208
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`MINIREVIEW
`
`The MutT proteins or “nudix” hydrolases, a family of
`versatile, widely distributed, “house cleaning” enzymes.
`Maurice J. Bessman, David N. Frick, and Suzanne F.
`O'Handley
`
`CONTENTSArranged by Subject Categories
`25227
`Overexpression of a constitutively active form of phos-
`phatidylinositol 3-kinase is sufficient to promote Glut 4
`translocation in adipocytes. Jean-Francois Tanti, Thierry
`Grémeaux, Sophie Grillo, Véronique Calleja, Anke Klippel,
`Lewis T. Williams, Emmanuel Van Obberghen, and Yannick
`Le Marchand-Brustel
`
`CELL BIOLOGY AND METABOLISM
`Communication—Calmodulin binds to and inhibits GTP
`binding of the Ras-like GTPase Kir/Gem. Roland Fischer,
`Yu Wei, John Anagli, and Martin W. Berchtold
`Site-directed mutagenesis of nm23-H1. Mutation of pro-
`line 96 or serine 120 abrogates its motility inhibitory
`activity upon transfection into humanbreast carcinoma
`cells. Nicholas J. MacDonald, José M.P. Freije, Mary L.
`Stracke, Richard E. Manrow, and Patricia S. Steeg
`Altered regulation of G, cyclins in oxidant-induced
`growth arrest of lung alveolar epithelial cells. Accumu-
`lation of inactive cyclin E-CDK2 complexes. Sophie
`Corroyer, Bernard Maitre, Véronique Cazals, and Annick
`Clement
`
`Identification of histone H2A.X as a growth factor se-
`creted by an androgen-independent subline of mouse
`mammary carcinoma cells. Yoshio Watabe, Hiroaki
`Kuramochi, Yuzo Furuya, Nobuya Inagaki, Susumu Seino,
`Sadao Kimura, and Jun Shimazaki
`Function and expression of flavohemoglobin in Saccha-
`romyces cerevisiae. Evidencefor a role in the oxidative
`stress response. Xiao-Jian Zhao, Desmond Raitt, Patricia V.
`Burke, Amy S. Cleweil, Kurt E. Kwast, and Robert O. Poyton
`Specific phospholipid association with apolipoprotein
`A-I stimulates cholesterol efflux from humanfibroblasts.
`Studies with reconstituted sonicated lipoproteins. Yuwei
`Zhao, Daniel L. Sparks, and Yves L. Marcel
`Adducin regulation. Definition of the calmodulin-bind-
`ing domain andsites of phosphorylation by protein ki-
`nases A andC.Yoichiro Matsuoka, Christine A. Hughes, and
`Vann Bennett
`°
`
`Clostridium novyi a-toxin-catalyzed incorporation of
`GlcNAc into Rho subfamily proteins. Jérg Selzer, Fred
`Hofmann, Gundula Rex, Matthias Wilm, Matthias Mann, Ingo
`Just, and Klaus Aktories
`Phosphopleckstrin inhibits GBy-activable platelet phos-
`phatidylinositol-4,5-bisphosphate 3-kinase. Charles S.
`Abrams, Jin Zhang, C. Peter Downes, Xiu-wen Tang, Wei Zhao,
`and Susan E. Rittenhouse
`
`p130°45 formsa signaling complex with the adapter pro-
`tein CRKL in hematopoietic cells transformed by the
`BCR/ABL oncogene. Ravi Salgia, Evan Pisick, Martin
`Sattler, Jian-Liang Li, Naoki Uemura, Wai-Keung Wong,
`Stephen A. Burky, Hisamaru Hirai, Lan Bo Chen, and James D.
`Griffin
`A tyrosine kinase signaling pathway accounts for the
`majority of phosphatidylinositol 3,4,5-trisphosphate for-
`mation in chemoattractant-stimulated human neutro-
`phils. Andrzej Ptasznik, Eric R. Prossnitz, Dan Yoshikawa,
`Alan Smrcka, Alexis E. Traynor-Kaplan, and Gary M. Bokoch
`Covalent attachment of FAD derivatives to a fusion pro-
`tein consisting of 6-hydroxy-p-nicotine oxidase and a mi-
`tochondrial presequence. Folding, enzyme activity, and
`import of the modified protein into yeast mitochondria.
`Michaela Stoltz, Joachim Rassow, Andreas F. Biickmann, and
`Roderich Brandsch
`
`25240
`
`25277
`
`25308
`
`25327
`
`25369
`
`25400
`
`25406
`
`25430
`
`25446
`
`25452
`
`25479
`
`25492
`
`25506
`
`A predictive scale for evaluating cyclin-dependent ki-
`nase substrates. A comparison of p34°*? and p33°?*?,
`Jennifer K. Holmes and Mark J. Solomon
`
`Secretagoguesiticrease the expression of surfactant pro-
`tein A receptors on lungtypeII cells. Qiping Chen, Sandra
`R. Bates, and Aron B. Fisher
`
`Interaction of phosphorylated FceRIy immunoglobulin
`receptor tyrosine activation motif-based peptides with
`dual and single SH2 domainsof p72”*. Assessment of
`binding parameters and real time binding kinetics. Ting
`Chen, Barbara Repetto, Richard Chizzonite, Christine Pullar,
`Charles Burghardt, Elizabeth Dharm, Zhicheng Zhao, Robert
`Carroll, Perla Nunes, Mitali Basu, Waleed Danho, Mike
`Visnick, Jarema Kochan, David Waugh, and Alasdair M.
`Gilfillan
`
`Regulation of obese (ob) mRNA and plasmaleptin levels
`in rhesus monkeys.Effects of insulin, body weight, and
`non-insulin-dependent diabetes mellitus. Kikuko Hotta,
`Thomas A. Gustafson, Heidi K. Ortmeyer, Noni L. Bodkin,
`Margery A. Nicolson, and Barbara C. Hansen
`
`Theantibiotic bicyclomycin affects the secondary RNA
`binding site of Escherichia coli transcription termina-
`tion factor Rho. Attila Magyar, Xiangdong Zhang, Harold
`Kohn, and William R. Widger_
`
`Interleukin-8 (IL-8), melanoma growth-stimulatory ac-
`tivity, and neutrophil-activating peptide selectively me-
`diate priming of the neutrophil NADPH oxidase through
`the type A or type B IL-8 receptor. Simon P. Green, Anan
`Chuntharapai, and John T. Curnutte
`
`Modulation of GDP release from transducin by the con-
`served Glu’*4-Arg!®5 sequence in rhodopsin. Shreeta
`Acharya and Sadashiva S. Karnik
`
`The regulated secretion and vectorial targeting of neu-
`rotrophins in neuroendocrine and epithelial cells. John
`V. Heymach, Jr., Alex Kriittgen, Ueli Suter, and Eric M. Shooter
`
`Cytosolic and membrane-associated proteins involved in
`the recruitment of AP-1 adaptors onto the trans-Golgi
`network. Matthew N. J. Seaman, Penelope J. Sowerby, and
`Margaret S. Robinson
`
`Identification of a novel guanine nucleotide exchange
`factor for the Rho GTPase. Matthew J. Hart, Sanju Sharma,
`Nadia elMasry, Rong-Guo Qiu, Peter McCabe, Paul Polakis,
`and GideonBollag
`
`Double-stranded RNA-dependent protein kinase medi-
`ates c-Myc suppression induced bytypeI interferons.Tal
`Raveh, Ara
`Hovanessian, Eliane F. Meurs, Nahum
`Sonenberg, and Adi Kimchi
`
`Hypoxia-inducible protein binding to vascular endothe-
`lial growth factor mRNA and its modulation by the
`von Hippel-Lindau protein. Andrew P. Levy, Nina S. Levy,
`and Mark A. Goldberg
`
`Formationof a ligand-bindingsite for the acetylcholine
`receptorin vitro. Svetiana S. Shtrom and Zach W.Hall
`
`The JBCis available on World Wide Web. URL: Attp:/ /www-jbc.stanford.edu /jbc/
`Full Instructions to Authors will be found in (1996) J. Biol. Chem. 271, 15845-15848, and reprints may be obtained from theeditorialoffice.
`iii
`
`Page 3 of 12
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`Page 3 of 12
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`25533
`
`25569
`
`Interactions between Src homology (SH) 2/SH3 adapter
`proteins and the guanylnucleotide exchange factor SOS
`are differentially regulated by insulin and epidermal
`growthfactor. Shuichi Okada and Jeffrey E. Pessin
`
`Activation of protein-tyrosine phosphatase SH-PTP2 by
`a tyrosine-based activation motif of a novel brain mole-
`cule. Hiroshi Ohnishi, Misae Kubota, Atsuko Ohtake, Kazuki
`Sato, and Shin-ichiro Sano
`}
`
`25167
`
`25184
`
`The ATP bindingcassette transporters Pdr5 and Snq2 of
`Saccharomyces cerevisiae can mediate transport of ste-
`roids in vivo. Yannick Mahé, Yves Lemoine, and Karl Kuchler
`
`Function of Xenopuscystic fibrosis transmembrane con-
`ductance regulator (CFTR) Cl- channels and use of hu-
`man-Xenopus chimeras to investigate the pore proper-
`ties of CFTR. Margaret P. Price, Hiroshi Ishihara, David N.
`Sheppard, and Michael J. Welsh
`
`v
`
`25598
`a7 integrin mediatescell adhesion and migration on spe-
`25247=Interaction of ATP bindingsites in the ArsA ATPase, the
`cific laminin isoforms. Chung-Chen Yao, Barry L. Ziober,
`catalytic subunit of the Ars pump.Jiaxin Li, Shusen Liu,
`Rachel M. Squillace, and Randall H. Kramer
`and Barry P. Rosen
`
`25630
`
`25677
`
`25684
`
`25692
`
`25071
`
`25213
`
`25316
`
`25332
`
`25611
`
`25699
`
`25079
`
`25139
`
`Degradation of 3-hydroxy-3-methylglutaryl-CoA reduc-
`tase in endoplasmic reticulum membranesis accelerated
`as a result of increased susceptibility to proteolysis. Todd
`P. McGee, Helen H. Cheng, Hidetoshi Kumagai, Satoshi Omura,
`and Robert D. Simoni
`
`Phosphorylation of extracellular domains of T-lympho-
`cyte surface proteins. Constitutive serine and threonine
`phosphorylation of the T cell antigen receptor ectodo-
`mains. Sergey G. Apasovu, Patrick T. Smith, Marie T. Jelonek,
`David H. Margulies, and Michail V. Sitkousky
`Cell-surface cytokeratin 8 is the major plasminogenre-
`ceptor on breast cancer cells and is required for the
`accelerated activation of cell-associated plasminogen by
`tissue-type plasminogen activator. Todd A. Hembrough, Li
`Li, and Steven L. Gonias
`
`Therole of phosphatidylcholine biosynthesis in the reg-
`ulation of the INO1 gene of yeast. Peter Griac, Marci J.
`Swede, and Susan A. Henry
`
`ENZYMOLOGY
`Phospholipase C £2 association with phospholipid inter-
`faces assessed by fluorescence resonance energy trans-
`fer. G protein By subunit-mediated translocation is not
`required for enzymeactivation. Valerie Romoser, Rebecca
`Ball, and Alan V. Smrcka
`
`Inhibition of phospholipase D by a protein factor from
`bovine brain cytosol. Partial purification and character-
`ization of the inhibition mechanism. Jae Ho Kim, Yoon
`Jung Suh, Taehoon G. Lee, Yong Kim, Sun Sik Bae, Myung
`Jong Kim, J. David Lambeth, Pann-Ghill Suh, and Sung Ho
`Ryu
`
`Phosphatidylinositol 4,5-bisphosphate binding to the
`pleckstrin homology domain of phospholipase C-61 en-
`hances enzyme activity. Jon W. Lomasney, Hwei-Fang
`Cheng, Li-Ping Wang, Y.-S. Kuan, S.-M. Liu, Stephen.W.Fesik,
`and Klim King
`
`Ca?* binding to the first epidermal growth factor-like
`domain of human blood coagulation factor IX promotes
`enzymeactivity and factor VIII light chain binding.Peter
`J. Lenting, Olivier D. Christophe, Hans ter Maat, D. Jasper G.
`Rees, and Koen Mertens
`
`Allosteric activation of t-lactate dehydrogenase ana-
`lyzed by hybrid enzymes with effector-sensitive and
`-insensitive subunits. Shinya Fushinobu, Kenji Kamata,
`So Iwata, Hiroshi Sakai, Takahisa Ohta, and Hiroshi
`Matsuzawa
`
`The calmodulin-dependent phosphodiesterase gene
`PDEIC encodes several functionally different splice
`variants in a tissue-specific manner. Chen Yan, Allan Z.
`Zhao, J. Kelley Bentley, and Joseph A. Beavo
`
`MEMBRANES AND BIOENERGETICS
`
`Selectivity of the renal collecting duct water channel
`aquaporin-3. Miriam Echevarria, Erich E. Windhager, and
`Gustavo Frindt
`
`Transport mechanism of the cloned potato H*/sucrose
`cotransporter StSUT1. Kathryn J. Boorer, Donald D. F. Loo,
`Wolf B. Frommer, and Ernest M. Wright
`
`25338 Mechanisms for the transport of a,w-dicarboxylates
`through the mitochondrial inner membrane. Guoying Liu,
`Bryan Hinch, and Andrew D. Beavis
`
`25438
`
`Probing conserved regions of the cytoplasmic LOOP1
`segment linking transmembrane segments 2 and 3 of the
`Saccharomyces cerevisiae plasma membrane H*-ATPase.
`Genfu Wang, Markus J. Tamds, Michael J. Hall, Amparo
`Pascual-Ahuir, and David S. Perlin
`
`25582 Membrane topology of the sodium ion-dependent citrate
`carrier of Klebsiella pneumoniae. Evidence for a new
`structural class of secondary transporters. Marleen van
`Geest and Juke S. Lolkema
`
`25590 Determination of the transmembranetopology of yeast
`Sec61p, an essential component of the endoplasmic re-
`ticulum translocation complex. Barrie M. Wilkinson,
`Angela J. Critchley, and Colin J. Stirling
`
`25604 Mechanism responsible for oligomycin-induced occlu-
`sion of Na* within Na/K-ATPase. Teruyo Arato-Oshima,
`Hideo Matsui, Akira Wakizaka, and Haruo Homareda
`
`NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND
`MOLECULAR GENETICS
`
`25089
`
`Recognition of DNA adducts by human nucleotide exci-
`sion repair. Evidence for a thermodynamic probing
`mechanism. Daniela Gunz, Martin T. Hess, and Hanspeter
`Naegeli
`:
`
`25178 Molecular design of inhibitors of in vitro oriC DNA rep-
`lication based on the potential to block the ATP binding
`of DnaA protein. Tohru Mizushima, Shigeki Sasaki, Hiroko
`Ohishi, Masakatsu Kobayashi, Tsutomu Katayama, Takeyoshi
`Miki, Minoru Maeda, and Kazuhisa Sekimizu
`
`25233
`
`25253
`
`25269
`
`The chick a2(I) collagen gene contains two functional
`promoters, and its expression in chondrocytesis regu-
`lated at both transcriptional and post-transcriptional
`levels. Kim M.Pallante, Zeling Niu, Yufeng Zhao, Arthur J.
`Cohen, Hyun-Duck Nah, and Sherrill L. Adams
`
`The interferon (IFN)-stimulated gene Sp100 promoter
`contains an IFN-y activation site and an imperfect IFN-
`stimulated response element which mediate type I IFN
`inducibility. Thilo Grotzinger, Kirsten Jensen, and Hans Will
`
`Characterization of the human cytochrome P4502D6
`promoter. A potential role for antagonistic interactions
`between membersof the nuclearreceptor family. William
`Cairns, Christopher A. D. Smith, Aileen W. McLaren, and C.
`Roland Wolf
`
`25292
`
`Twodistinct promoters drive transcription of the human
`D,, dopamine receptor gene. Sang-Hyeon Lee, Mari T.
`Minowa, and M. Maral Mouradian
`25300 Molecular characterization of a novel human endothelin
`receptor splice variant. Nabil A. Elshourbagy, John E.
`Adamou,Alison W. Gagnon, Hsiao-Ling Wu, Mark Pullen, and
`Ponnal Nambi
`
`25345
`
`The related molecular chaperones calnexin and calreti-
`culin differentially associate with nascent T cell antigen
`receptor proteins within the endoplasmic reticulum.
`Jeroen E. M. Van Leeuwen and Kelly P. Kearse
`
`
`
`The Journal ofBiological Chemistry (ISSN 0021-9258) is published weekly by the American Society for Biochemistry and Molecular Biology, Inc., 9650
`Rockville Pike, Bethesda, MD 20814. Volume 271 for 1996: Institutions:
`nited States, $1,150, pa $1,340. Students/Postdoctoral Fellows: United
`SCI
`ription): United States, $75; Foreign, $80. (Note:
`States, $165; Foreign, $355. Single copies ofthe Journal are $26. CD-ROM(available only with printed su
`Maryland and Canada addapplicable taxes, unless a tax-exempt certificate number is shown.) The GST numberfor Canadian subscribers is 130370018.
`C.P.C Intl Pub Mail # 0060119. Periodicals postage paid at Bethesda, MD 20814, U.S.A. and at additional mailing offices. Printed in the U.S.A.
`POSTMASTER:Send address changes to THE JOURNAL OF BIOLOGICAL CHEMISTRY at P.O. Box 830399, Birmingham, AL 35283-0399, U.S.A.
`EEE
`
`Page 4 of 12
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`Page 4 of 12
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`|
`
`25350
`
`25360
`
`The v-Ki-Ras oncogene alters cAMP nuclear signaling by
`regulating the location and the expression of
`-de-
`pendent protein kinase IIf. A. Feliciello, P. Giuliano, A.
`Porcellini, C. Garbi, S. Obici, E. Mele, E. Angotti, D. Grieco, G.
`Amabile, S. Cassano, Y. Li, Anna M. Musti, Charles S. Rubin,
`Max E. Gottesman, and Enrico V. Avvedimento
`A partially functional DNA helicase II mutant defective
`in forming stable binary complexes with ATP and DNA.
`Arole for helicase motif III. Robert M. Brosh, Jr. and Steven
`W. Matson
`
`25375
`
`25423
`
`25459
`
`25485
`
`25498
`
`Inducible cAMPearly repressor can modulate tyrosine
`hydroxylase gene expression after stimulation of cAMP
`synthesis. Cristina Tinti, Bruno Conti, Joseph F. Cubells,
`Kwang-Soo Kim, Harriet Baker, and Tong H. Joh
`Identification of the cpdA gene encoding cyclic 3’,5'-
`adenosine monophosphate phosphodiesterase in Esche-
`richia coli. Ryu Imamura, Kunitoshi Yamanaka, Teru Ogura,
`Sota Hiraga, Nobuyuki Fujita, Akira Ishihama, and Hironori
`Niki
`Identification of functional elements of the chicken
`e-globin promoter involved in stage-specific interaction
`with the B/e enhancer. Mark M. Mason, Joseph A. Grasso,
`Oksana Gavrilova, and Marc Reitman
`Characterization of human B creatine kinase gene reg-
`ulation in the heart in vitro and in vivo. Michael E. Ritchie
`Structure and characterization of the humantissue in-
`hibitor of metalloproteinases-2 gene. Khalil Hammani,
`Andrew Blakis, Delmore Morsette, Anne M. Bowcock, Christoph
`Schmutte, Patrick Henriet, and Yves A. DeClerck
`25515 Molecular cloning and characterization of a novel mouse
`macrophagegene that encodes a nuclear protein com-
`prising polyglutamine repeats and interspersing histi-
`dines. George W. Cox, Lynn S. Taylor, Jonathan D. Willis,
`Giovanni Melillo, Robert L. White III, Stephen K. Anderson, and
`Jih-Jing Lin:
`Identification of a novel retinoic acid response element
`in the promoter region of the retinol-binding protein
`gene. Luigi Panariello, Loredana Quadro, Sergio Trematerra,
`and Vittorio Colantuoni
`
`25524
`
`25539
`
`25548
`
`25555
`
`25562
`
`Evidencethat a specific interaction between an 18-base
`cis-elementin the 5'-untranslated region of humanfolate
`receptor-a mRNAand a 46-kDacytosolic érans-factor is
`critical for translation. Xin-Lai Sun and Asok C. Antony
`
`Cloning and developmental expression of a membrane-
`type matrix metalloproteinase from chicken. Maozhou
`Yang, Kimiko Hayashi, Masando Hayashi, JoanneT. Fujii, and
`Markku Kurkinen
`
`Interleukin-4-induced STAT6 recognizes and activates a
`target site in the promoterof the interleukin-4 receptor
`gene. Helen Kotanides and Nancy C. Reich
`Characterization of Elongin C functional domains re-
`quired for interaction with Elongin B and activation of
`Elongin A. Yuichiro Takagi, Ronald C. Conaway, and Joan
`Weliky Conaway
`
`25617
`
`Redox regulation of GA-binding protein-a DNA binding
`activity. Mark E. Martin, Yurii Chinenov, Mi Yu, Tonya K.
`Schmidt, and Xiu-Ying Yang
`
`25624 Different inducibility of expression of the two xylanase
`genes xyn1 and xyn2 in Trichoderma reesei. Susanne
`Zeilinger, Robert L. Mach, Martin Schindler, Petra Herzog, and
`Christian P. Kubicek
`
`25689
`
`25657
`
`25671
`
`25715
`
`Enhanced tumorigenic behaviorof glioblastomacells ex-
`pressing a truncated epidermal growth factor receptor
`is mediated through the Ras-Shc-Grb2 pathway.Sally A.
`Prigent, Motoo Nagane, Hong Lin, Ivana Huvar, Gerry R. Boss,
`James R. Feramisco, Webster K. Cavenee, and H.-J. Su Huang
`
`Specific mutations near the amino terminus of double-
`stranded RNA-dependentprotein kinase (PKR) differen-
`tially affect its double-stranded RNA binding and dimer-
`ization properties. Rekha C. Patel, Paul Stanton, and Ganes
`C. Sen
`
`Factor VIII C2 domain missense mutations exhibit defec-
`tive trafficking of biologically functional proteins. Steven
`W. Pipe and Randal J. Kaufman
`
`Parathyroid hormoneinduces c-fos promoteractivity in
`osteoblastic cells through phosphorylated cAMP re-
`sponse element (CRE)-binding protein binding to the
`major CRE.A. Terrece Pearman, Wan-Yin Chou, Kimberly D.
`Bergman, Malini R. Pulumati, and Nicola C. Partridge
`
`PROTEIN CHEMISTRY AND STRUCTURE
`
`25063
`
`#Communication—Nucleotides reveal polynucleotide phos-
`phorylase activity from conventionally purified GroEL.
`Jesse Ybarra and Paul M. Horowitz
`
`25083 Heterologous expression of three plant serpins with dis-
`tinct inhibitory specificities. Sgren W. Dahl, Sgren K.
`Rasmussen, and Jorn Hejgaard
`
`25099 Anovelactivating anti-61 integrin monoclonal antibody
`bindsto the cysteine-rich repeatsin the B1 chain. Randall
`J. Faull, Jian Wang, David I. Leavesley, Wilma Puzon, Graeme
`R. Russ, Dietmar Vestweber, and Yoshikazu Takada
`
`25152
`
`A recombinant sickle hemoglobin triple mutant with
`independent
`inhibitory effects on polymerization.
`Juha-Pekka Himanen, Urooj A. Mirza, Brian T. Chait, Robert
`M. Bookchin, and James M. Manning
`
`25220 Mutations at domain II, loop 3, of Bacillus thuringiensis
`CryIAa and CrylAb 6-endotoxins suggest loop 3 is in-
`volved in initial binding to lepidopteran midguts. Francis
`Rajamohan, Syed-Rehan A. Hussain, Jeffrey A. Cotrill, Fred
`Gould, and Donald H. Dean
`
`25261 Modulation of structure and antibacterial and hemolytic
`activity by ring size in cyclic gramicidin S analogs.Leslie
`H. Kondejewski, Susan W. Farmer, David S. Wishart, Cyril M.
`Kay, Robert E. W. Hancock, and Robert S. Hodges
`
`
`
`GENERAL INFORMATION
`
`This publication is available on CD-ROM.Inquire about availability through
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`permission to reproduce any part of a previously published article should be
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`The Journal of Biological Chemistry publishes papers on a broad range of
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`
`vii
`
`lethal factor from stonefish
`Stonustoxin is a novel
`(Synanceja horrida) venom. cDNA cloning and charac-
`terization. Farid John Ghadessy, Desong Chen,
`R.
`Manjunatha Kini, Maxey C.M. Chung, Kandiah Jeyaseelan,
`Hoon Eng Khoo, and Raymond Yuen
`
`Identification of Itk/Tsk Sre homology 3 domain ligands.
`Stephen C. Bunnell, Pamela A. Henry, Rikki Koiluri, Tomas
`Kirchhausen, Richard J. Rickles, and Leslie J. Berg
`Purification and characterization of a novel restricted
`antigen expressed by normal and transformed human
`colonic epithelium.B. Catimel, G. Ritter, S. Welt, L. J. Old, L.
`Cohen, M.A. Nerrie, S. J. White, J. K. Heath, B. Demediuk, T.
`Domagala, F. T. Lee, A. M. Scott, G. F. Tu, H. Ji, R. L. Moritz,
`R. J. Simpson, A. W. Burgess, and E.C. Nice
`
`Mutagenesis analysis of functionally important domains
`within the C-terminal end of smooth muscle caldesmon.
`Ze Wan