CURRICULUM VITAE
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`Edward Chaum, M.D., Ph.D.
`Margy Ann and J. Donald M. Gass Chair, Professor of Ophthalmology and Visual Sciences,
`Professor of Pathology, Microbiology & Immunology, and Biomedical Engineering
`Vanderbilt University Medical Center
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`EDUCATION
`Undergraduate:
`Johns Hopkins University, (Baltimore, MD), B.A., May 1979, Natural Sciences
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`Graduate:
` Cornell Graduate School of Medical Sciences (New York, NY), Ph.D., May 1986
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`Cell Biology and Genetics
` Cornell University Medical College (New York, NY), M.D., May 1987
`Postgraduate Training:
`Residencies:
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`Pediatrics, Massachusetts General Hospital (Boston, MA), July 1987 - June 1990
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`Ophthalmology, Boston University Hospital (Boston, MA), July 1990 - June 1993
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` Fellowship:
`Retina, Massachusetts Eye & Ear Infirmary (Boston, MA), July 1993 - June 1994
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`BOARD CERTIFICATION
`The National Board of Medical Examiners, July 1988
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`The American Board of Pediatrics, November 1990, Re-certified 5/1999, 12/2005, (retired 2016)
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`The American Board of Ophthalmology, May 1995, Re-certified 12/2005, 12/2015 (active)
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`ACADEMIC APPOINTMENTS
` University of Massachusetts Medical Center, Worcester, MA
`• Assistant Professor of Ophthalmology, Pediatrics and Cell Biology July 1994 – June 2000
`Interim Chief, Division of Ophthalmology, October 1998 - June 2000
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` University of Tennessee Health Science Center, College of Medicine, Memphis, TN
`Plough Foundation Professor of Retinal Diseases, 2000 – 2018 (emeritus)
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`Assistant Professor of Ophthalmology and Pediatrics, 2000 – 2001
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`Associate Professor of Ophthalmology (with tenure), Assoc. Professor of Pediatrics 2001-6
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`Professor of Ophthalmology, July 2006
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`Professor of Pediatrics, Anatomy and Neurobiology, and Biomedical Engineering, July 2007.
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`Hamilton Eye Institute, Director of Research: July 2014 - 2018
`•
` University of Tennessee Health Science Center, College of Graduate Health Sciences
` Graduate School Faculty, December 2004 - present
` University of Memphis, Memphis, TN
`Adjunct Graduate Faculty, Department of Biomedical Engineering, July 2005 – present
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`Vanderbilt University Medical Center, Nashville, TN
` Margy Ann and J. Donald M. Gass Chair, Professor of Ophthalmology & Visual Sciences, 2018 -
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`Professor of Pathology, Microbiology & Immunology, 2018 -
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`Professor of Biomedical Engineering, 2018 -
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`HOSPITAL APPOINTMENTS
`Tennessee
`Vanderbilt University Medical Center – 2018
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`PROFESSIONAL EXPERIENCE (Administrative)
`UMass Memorial Health Care, Worcester, MA
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`Interim Chief, Division of Ophthalmology and Director, Vitreoretinal Service
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`October 1998 - June 2000, 8 physician, 15 staff member hospital Division
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`PROFESSIONAL ORGANIZATIONS
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`American Academy of Ophthalmology
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`Alpha Omega Alpha Honor Medical Society
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`Retina Society, Macula Society
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`Association for Research in Vision and Ophthalmology
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`American Telemedicine Association
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`Research to Prevent Blindness, Fight for Sight
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`PROFESSIONAL ACTIVITIES
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`Intramural - UTHSC
` UTHSC Institutional Review Board, 2000 – 2007
` Clinical Research Center, Scientific Advisory Committee, 2001 – 2011
` UTMG Professional Practices Committee, 2005 – 2015
` CTSI Scientific Advisory Board, 2008 – 2013
` Strategic Planning Steering Committee, 2009 – 2018
` Vice Chancellor for Research Search Committee, 2010
` Post-Graduate Grievance Committee, 2011 – 2018
` Director HEI Vision Core, 2013- 2017
` UTHSC-ORNL Center for Biomedical Informatics Governance Committee – 2014
` HEI, Director of Research, 2014 - 2018
` Molecular Resource Center Advisory Board, 2016 - 2018
` Ophthalmology Chair Search Committee, 2017
` Intramural - VUMC
`Store and Forward Telemedicine Committee, VUMC
`Neurology Chair Search Committee, VUMC
`Snyder Chair Review Committee, VUMC
`Edge Review Committee, VUMC. Internal mock Study Section
` Extramural
`• National Eye Institute, NIH. Peer Review Study Sections, VisC, BDPE, DPVS, others; 2006 – 22
`• Academic Editor: PLoS ONE, 2011-16
`• Editorial Reviewer: 2000 - present
`American Journal of Ophthalmology, Archives of Ophthalmology, Autophagy, British
`Journal of Ophthalmology, British Journal of Pharmacology, Experimental Eye Research,
`Investigative Ophthalmology and Visual Science, Journal of Cellular Biochemistry, Journal of
`Cellular Physiology, Journal of Gene Medicine, Journal of Pharmacy and Pharmacology, Lipids,
`Molecular Vision, Ophthalmology, Pan American Journal of Public Health, PLoS ONE, Retina,
`Survey of Ophthalmology, IEEE Transactions in Medical Imaging, IEEE Computers in Biology
`and Medicine, SPIE, and others.
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`• Invited Grant and Fellowship Reviewer for International Funding Agencies
`Wellcome Trust, Great Britain, The Health Research Board, Ireland,
`Erwin Schroedinger-Post-Doctoral Research Fellowship, Austrian Science Fund; Fight for
`Sight, New York, NY, Prevent Blindness America, ARVO, Technology Foundation STW
`(Netherlands); Catalan Agency for Health Technology Assessment and Research, Spain;
`Medical Research Council, Great Britain; Canada Innovation Research, others
` Other Professional Activities
` Executive Committee Advisor, Fight for Sight, New York, NY, 2005- 2017
` Board of Directors, Juvenile Diabetes Research Foundation, West TN Chapter, 2007 - 2011
` Oak Ridge National Laboratory, External Advisory Board, Biomedical Science & Engineering, 2012
` SENSORIUM: University of Memphis – Founding Principal Researcher, 2013 - present
` Board of Directors, Research Inc., Memphis VA Medical Center, 2014 – 2018
` VUMC Endowed Chair Review Committees (various) 2019- present
`Entrepreneurial
`1. Hubble Telemedical - Founder and CMO
`Winner, R&D100 Award, 2010 – TRIAD Telemedical Network
`Winner Federal Laboratory Consortium Award for Technology Transfer, 2010
`Winner, American Telemedicine Association Innovation Award, 2011
`USDA Phase I SBIR 2012, Phase II SBIR 2013
`Venture-backed telemedicine start up company. Acquired by Welch Allyn, 2015
`2. Infusense – Founder and CMO
`Angel-backed start up in the biomedical sensor space
`SEBIO Finalist 2011, DOD Phase I SBIR, 2012
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`3. Plexitome - Founder and CMO
`Venture-backed start up in the surgical device space
`4. Focal Point Pharmaceuticals, Co-Founder and CSO
`Venture-backed start up company.
`5. Ipax Pharmaceuticals, Co-Founder and CMO
` Grant-backed start up company.
`Issued Patents
`1. Method and system for the diagnosis of disease using retinal image content and an archive of
`diagnosed human patient data US 8243999, Sept. 20, 2012
`2. Method and system for assigning a confidence metric for automated determination of optic disc
`location US 8218838, July 10, 2012
`3. Retinal instrument US 8425596, April 23, 2013
`4. Microfabricated instruments and methods to treat recurrent corneal erosions, US 8591481, Nov.
`26, 2013
`5. US 9044299, Jun. 02, 2015
`6. Method and device for detection of bioavailable drug concentration in a fluid sample
`US #9700246, July 11, 2017.
`7. #9983162, 5/29/2018
`8. Notice of Allowance US Application No. 15/989,765
`9. Canada CLP #2740421; August 28, 2018, #2875003; September 29, 2020
`10. EPO #2856133, April 12, 2018
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`Special Awards and Recognition
`
`1992
` Alpha Omega Alpha, Honor Medical Society
`1998
` Research Career Award (K08), National Eye Institute, NIH
`2000
` Plough Foundation Professor of Retinal Diseases, University of Tennessee, endowed Chair
`2006-13 Best Doctors in America®
`2009 Keynote Speaker: 1st Annual Biomedical Science & Engineering Conf., Oak Ridge Natl. Lab.
`2009
`Senior Scientist Award, Research to Prevent Blindness, New York, NY
`2010 R&D100 Award – Life Sciences: “TRIAD Network”
`2010
`Federal Laboratory Consortium Award for Technology Transfer, with ORNL
`2011 American Telemedicine Association Innovation Award: Hubble Telemedical, Inc.
`2013 Memphis Business Quarterly, Inaugural 2013 Innovation Award
`2013 B. Otto Wheeley Award for Excellence in Technology Transfer, University of Tennessee
`2014 Hamilton Eye Institute, Director of Research
`2018 Elected to Retina Society
`2018 Elected to Macula Society
`2018 Margy Ann and J. Donald M. Gass Chair, Professor of Ophthalmology and Visual Sciences
`Invited Lectures
`New England Ophthalmological Society, April 1999
`Keynote Speaker: Tennessee Academy of Sciences, Collegiate Division, May, 2005
`Keynote Speaker: 1st Biomedical Science & Engineering Conference, ORNL, March, 2009
`Keynote Speaker: National Council of University Research Administrators, April 2013
`Keynote Speaker: St Jude Children’ Research Hospital, March 2013
`University of Memphis, Fogelman College of Business, 2015, 2017
`RESEARCH PROGRAMS:
`Clinical Science – Multicenter Clinical Trials
`Diabetes Prevention Program Outcomes Studies, DCCT and EDIC: 2005- present
` Clinical Study Center, Clinical Co-investigator UTHSC/VUMC study site
` Clinical outcomes of diabetes prevention and treatment programs
`Age-Related Eye Disease Study II (AREDS2) 2006 - present
` Clinical Study Center, Clinical Co-investigator UTHSC study site
` Clinical outcomes of diabetes prevention and treatment programs
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`https://www.vumc.org/ophthalmology/chaum-laboratory-translational-bioengineering-and-medicine
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`https://orcid.org/0000-0003-3542-8376
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`Publications and Presentations:
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`A. Basic Science Research and Clinical Retina – Peer-reviewed Manuscripts:
`1. Chaum, E., Ellsworth, R.M., Haik, B.G., Kitchin, F.D., Chaganti, R.S.K. (1984) Cytogenetic
`analysis of retinoblastoma: Evidence for multifocal origin and in vivo gene amplification. Cytogenet
`Cell Genet 38: 82-91.
`2. Chaum, E., Doucette, L.A., Ellsworth, R.M., Haik, B.G., Kitchin, F.D., Chaganti, R.S.K. (1984)
`Bleomycin-induced chromosome breakage in G2 lymphocytes of retinoblastoma patients. Cytogenet
`Cell Genet 38:152-154.
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`3. Sakai, K., Kanda, N., Shiloh, Y., Donlon, T., Schreck, R., Shipley, J., Dryja, T., Chaum, E.,
`Chaganti, R.S.K., Latt, S. (1985). Molecular and cytologic analysis of DNA amplification in
`retinoblastoma. Cancer Genet Cytogenet 17: 95-112.
`4. Chaum E. (1987) Cytogenetic and Molecular Studies of the Role of Oncogenes in Transformation in
`Retinoblastoma. Cornell University GSMS. Copyright TX 2 084 403.
`5. Chaum, E. and Hatton, M.P. (1999) Congenital nystagmus associated with multiple congenital
`anomalies of extraocular muscles. J Ped Ophthalmol Strab 36:155-157.
`6. Chaum, E., Hatton, M.P. and Stein, G. (1999) Polyplex-mediated gene transfer into human retinal
`pigment epithelial cells in vitro. J Cell Biochem 76 (1): 153-160.
`7. Chaum, E., Drewry, RD, Ware, GT, Charles, S. (2001) Nerve fiber bundle visual field defect
`resulting from a giant peripapillary cotton-wool spot. J Neuro-Ophthalmol, 21:276-277.
`8. Chaum, E. (2001) Comparative analysis of the uptake and expression of plasmid vectors in human
`ciliary and retinal pigment epithelial cells in vitro. J Cell Biochem, 83:671-677.
`9. Chaum, E. and Greenwald, MA (2002) Retinochoroidal anastomoses and a choroidal neovascular
`membrane in a macular exudate following treatment for retinal macroaneurysms. Retina, 22:363-6.
`10. Chaum, E., Yang, H. (2002) Transgenic expression of IGF-1 modifies the proliferative potential of
`human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci, 43:3758-3764.
`11. Yang, H., Chaum, E. (2003) A Reassessment of Insulin-like Growth Factor Binding Protein Gene
`Expression in the Human Retinal Pigment Epithelium. J Cell Biochem, 89:933-943.
`12. Martin AC., Thornton JD, Liu J, Wang X, Zuo, J, Jablonski MM, Chaum E, Zindy F, Skapek SX.
`(2004) Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the Arf tumor suppressor
`gene. Invest Ophthalmol Vis Sci, 45(10):3387-96.
`13. Ashmore, E, Kerr, NC, Greenwald, M., Chaum, E. (2004) Natural History of Acquired Retinal
`Oxalosis in a Child. J Ped Ophthalmol Strab, 41:308-311.
`14. Chaum E, Fawzi A, Chang TS, Shah GK. (2006) Diagnostic and therapeutic challenges. Retina.
`26:219-22.
`15. Yang, H., Yang, X., Lang, J.C., Chaum, E. (2006) Tissue Culture Methods Can Strongly Upregulate
`Immediate Early Gene Expression in Retinal Pigment Epithelial Cells. J Cell Biochem. 98:1560-1569.
`16. Karnowski, T.P., Govindasamy, V.P., Tobin, K.W., Chaum, E., “Locating the Optic Nerve in Retinal
`Images: Comparing Model-Based and Bayesian Decision Methods,” 28th Annual International Conf. of
`the IEEE EMBS, August 2006.
`17. Tobin, K.W., Chaum, E., Govindasamy, V.P., Karnowski, T.P., Sezer, O., “Characterization of the
`Optic Disk in Retinal Imagery using a Probabilistic Approach”, SPIE International Symposium on
`Medical Imaging, San Diego, California, Proceedings of SPIE, Vol. 6144:61443F, February 2006.
`18. Tobin, K.W., Chaum, E., Govindasamy, V.P., Karnowski, T.P. (2007) “Detection of Anatomic
`Structures in Human Retinal Imagery,” IEEE Transactions on Medical Imaging, 26(12):1729-39.
`19. Tobin KW, Abdelrahman, M, Chaum E, Govindasamy VP, Karnowski TP. (2007) A Probabilistic
`Framework for Content-Based Diagnosis of Retinal Disease. Conf Proc IEEE Eng Med Biol Soc;
`2007:6744-6747.
`20. Tobin, KW, Abramoff, MD, Chaum, E, Giancardo, L, Govindasamy, VP, Karnowski, TP, Tennant,
`MTS. (2008) Using a Patient Image Archive to Diagnose Retinopathy. Conf. Proc. IEEE Eng Med Biol
`Soc 1:5441-5444.
`21. Karnowski, TP, Govindasamy, VP, Tobin, KW, Chaum, E, Abramoff, MD. (2008). Retina Lesion
`and Microaneurysm Segmentation using Morphological Reconstruction Methods with Ground-Truth
`Data. Conf. Proc. IEEE Eng Med Biol Soc 1:5433-5436.
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`22. Giancardo, L, Abramoff, MD, Chaum, E, Karnowski, TP, Meriaudeau, F, Tobin, KW. (2008)
`Elliptical Local Vessel Density: A Fast and Robust Quality Metric for Fundus Images. Conf. Proc. IEEE
`Eng Med Biol Soc 1:3534-3537.
`23. Chaum, E., Karnowski, T.P., Govindasamy, V.P., Tobin, K.W. (2008) Automated Diagnosis of
`Retinopathy by Content-Based Image Retrieval, Retina, 28:1463-1477.
`24. Fung, K, Mastellone, J, Chaum, E., (2008) Macular Neovascularization in Familial Exudative
`Vitreoretinopathy. Retinal Cases & Brief Reports. 2(4):319-321.
`25. Hoehn, ME, Merchant, TE, Chaum, E., (2008) Macular epiretinal membrane formation after low-
`dose radiation exposure in a child with papilledema from a craniopharyngioma. Retinal Cases & Brief
`Reports. 2(4):289-291.
`26. Karnowski TP, Aykac D, Chaum E, Giancardo L, Li Y, Tobin KW, Abramoff MD. (2009) Practical
`considerations for optic nerve location in telemedicine. Conf Proc IEEE Eng Med Biol Soc. 2009;1:6205-
`9.
`27. Chaum E, Yin J, Yang H, Thomas F, Lang JC. Quantitative AP-1 gene regulation by oxidative stress
`in the human retinal pigment epithelium. J Cell Biochem. 2009 Dec 15;108(6):1280-91.
`28. Chaum, E. Translating novel engineering concepts into biomedical research programs and clinical
`medicine, Biomedical Science & Engineering Conference, 2009. BSEC 2009. First Annual ORNL
`Conference, DOI: 10.1109/BSEC.2009.5090462
`29. Giddabasappa A, Bauler M, Yepuru M, Chaum E, Dalton JT, Eswaraka J. 17-β estradiol protects
`ARPE-19 cells from oxidative stress through estrogen receptor-β. Invest Ophthalmol Vis Sci. 2010
`Oct;51(10):5278-87.
`30. Boone, A.R.W.; Karnowski, T.P.; Chaum, E.; Giancardo, L.; Li, Y.; Tobin, K.W., Jr. Image
`processing and hierarchical temporal memories for automated retina analysis, Biomedical Sciences and
`Engineering Conference (BSEC), 2010, DOI: 10.1109/BSEC.2010.5767510
`31. Spentzas T, Henricksen J, Patters AB, Chaum E. (2010) Correlation of intraocular pressure with
`intracranial pressure in children with severe head injuries. Pediatr Crit Care Med. 2010;11(5):593-8.
`32. Karnowski, T.P. Aykac, D. Giancardo, L. Li, Y. Nichols, T. Fox, K. Garg, S. Tobin, K.W.
`Chaum, E. Combining image and non-image data for automatic detection of retina disease in a
`telemedicine network. Biomedical Sciences and Engineering Conference, March 2011.
`33. Giancardo L, Meriaudeau F, Karnowski TP, Li Y, Tobin KW, Chaum, E. Automatic quality
`enhancement and nerve fibre layer artefacts removal in retina fundus images by off axis imaging. Image
`Processing (ICIP), 18th IEEE International Conference, 2011; 49-52.
`34. Giancardo, L.; Meriaudeau, F.; Karnowski, T.P.; Li, Y.; Tobin, K.W.; Chaum, E. Automatic retina
`exudates segmentation without a manually labelled training set. Biomedical Imaging: From Nano to
`Macro, 2011 IEEE International Symposium, 2011; 1396-1400.
`35. Langmaier J, Garay F, Kivlehan F, Chaum E, Lindner E. Electrochemical Quantification of 2,6-
`Diisopropylphenol (Propofol), Analytica Chimica Acta, 2011, 704 (1-2):63-67.
`36. Santos-Villalobos H, Karnowski T, Aykac D, Giancardo L, Li Y, Nichols T, Tobin KW, Chaum E.
`Statistical characterization and segmentation of drusen in fundus images. Conf Proc IEEE Eng Med Biol
`Soc. 2011 Aug;2011:6236-41.
`37. Fowler B, Shen C, Mastellone J, Chaum E. Acute systemic histoplasmosis associated with
`chorioretinitis in an immunocompetent adolescent. Dig J Ophthalmol : DJO 2011;17(3):31-35.
`38. Karnowski TP, Aykac D, Giancardo L, Li Y, Nichols T, Tobin KW, Chaum E. Automatic detection
`of retina disease: Robustness to image quality and localization of anatomy structure. Conf Proc IEEE Eng
`Med Biol Soc. 2011 Aug;2011:5959-64.
`39. Giancardo L, Meriaudeau F, Karnowski TP, Li Y, Tobin KW, Chaum E. Microaneurysm detection
`with radon transform-based classification on retina images. Conf Proc IEEE Eng Med Biol Soc. 2011
`Aug;2011:5939-42.
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`40. Devisetti K, Karnowski TP, Giancardo L, Li Y, Chaum E. Geographic atrophy segmentation in
`infrared and autofluorescent retina images using supervised learning. Conf Proc IEEE Eng Med Biol Soc.
`Aug;2011:3958-61.
`41. Li Y, Karnowski TP, Tobin KW, Giancardo L, Morris S, Sparrow SE, Garg S, Fox K, Chaum E
`(2011) A Health Insurance Portability and Accountability Act–Compliant Ocular Telehealth Network for
`the Remote Diagnosis and Management of Diabetic Retinopathy, Telemedicine and e-Health, 2011
`Oct;17(8):627-34.
`42. Yin J, Thomas F, Lang JC, Chaum E. Modulation of oxidative stress responses in the human retinal
`pigment epithelium following treatment with vitamin C. J Cell Physiol. 2011;226(8):2025-32.
`43. Bhattacharya S, Ray RR, Chaum E, Johnson DA, and Johnson LR. Inhibition of Mdm2 sensitizes
`human retinal pigment epithelial cells to apoptosis. Invest. Ophthalmol. Vis. Sci. 2011;52(6):3368-80.
`44. Chaum E, Yin J, Lang JC. Molecular Responses Transduced by Serial Oxidative Stress in the
`Retinal Pigment Epithelium: Feedback Control Modeling of Gene Expression. Neurochem Res. 2011
`36:574-582.
`45. Giancardo L, Meriaudeau F, Karnowski T, Tobin K, Grisan E, Favaro P, Ruggeri A, Chaum E.
`Textureless Macula Swelling Detection with Multiple Retinal Fundus Images. IEEE Trans Biomed Eng.
`2011 Mar;58(3):795-9.
`46. Karnowski, T.P. Aykac, D. Giancardo, L. Li, Y. Nichols, T. Tobin, K.W. Chaum, E. Automatic
`Detection of Retina Disease: Robustness to Image Quality and Localization of Anatomy Structure. IEEE
`EMBC 2011, Boston, MA, 20110831.
`47. Bhattacharya S, Chaum E, Johnson DA, Johnson LR. Age-related susceptibility to apoptosis in
`human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association. Invest
`Ophthalmol Vis Sci. 2012; 53(13):8350-66.
`48. Garg S, Jani PD, Kshirsagar AV, King B, Chaum E. Telemedicine and Retinal Imaging for
`Improving Diabetic Retinopathy Evaluation, Arch Intern Med. 2012;172(21):1677-1680.
`49. Kivlehan FA, Garay F, Guo J, Chaum E, Lindner E. Towards feedback-controlled anesthesia:
`Voltammetric measurement of propofol (2,6-diisopropylphenol) in serum-like electrolyte solutions. Anal
`Chem. 2012 Sep 18;84(18):7670-6. PMID: 22900668.
`50. Paquit VC, Karnowski TP, Aykac D, Li Y, Tobin KW, Chaum E. Detecting flash artifacts in fundus
`imagery. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:1442-5. PMID: 23366172
`51. Hines-Beard J, Marchetta J, Gordon S, Chaum E, Geisert EE, Rex TS. A mouse model of ocular
`blast injury that induces closed globe anterior and posterior pole damage. Exp Eye Res. 2012;99:63-70
`52. Lindner E, Bordelon D, Kim MD, Dergunov SA, Pinkhassik E, Chaum E. Ion-Selective Optodes in
`a Sampling Capillary for Tear Fluid Analysis. Electroanalysis. 2012, 24(1):42–52.
`53. Giancardo L, Meriaudeau F, Karnowski TP, Li Y, Garg S, Tobin KW Jr., Chaum E. Exudate-based
`diabetic macular edema detection in fundus images using publicly available datasets, Med Image Anal.
`Med Image Anal. 2012 Jan;16(1):216-26.
`54. H.J. Santos-Villalobos, D.R. Barstow, M. Karakaya, C.B. Boehnen, E. Chaum. ORNL biometric eye
`model for iris recognition. In proceeding of: Biometrics: Theory, Applications and Systems, 2012 IEEE
`Fifth Int’l Conference on Biometrics Compendium. 01/2012; ISBN: 978-1-4673-1384-1.
`55. Karnowski, TP, Giancardo, L, Li, Y, Tobin, KW, Chaum, E. "Retina image analysis and ocular
`telehealth: The Oak Ridge National Laboratory-Hamilton Eye Institute case study," Conf Proc IEEE Eng
`Med Biol Soc. 2013;2013:7140-3.
`56. Ali S, Sidibé D, Adal KM, Giancardo L, Chaum E, Karnowski TP, Mériaudeau F. Statistical atlas
`based exudate segmentation. Comput Med Imaging Graph. 2013 Jul-Sep;37(5-6):358-68.
`57. Mériaudeau F, Sidibé D, Ali S, Adal KM, Giancardo L, Karnowski TP, Chaum E. Computer Aided
`Design for Diabetic Retinopathy. QCAV2013, 11th International Conference on Quality Control by
`Artificial Vision, Fukuoka, Japan 2013.
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`58. Ali S, Adal KM, Sidibé D, Chaum E, Karnowski TP, Mériaudeau F. Steerable wavelet transform for
`atlas based retinal lesion segmentation. QCAV2013, 11th International Conference on Quality Control by
`Artificial Vision, Fukuoka, Japan 2013.
`59. Trucco E, Ruggeri A, Karnowski T, Giancardo L, Chaum E, Hubschman JP, Al-Diri B, Cheung CY,
`Wong D, Abràmoff M, Lim G, Kumar D, Burlina P, Bressler NM, Jelinek HF, Meriaudeau F, Quellec G,
`Macgillivray T, Dhillon B. Validating Retinal Fundus Image Analysis Algorithms: Issues and a Proposal.
`Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3546-3559.
`60. Wing BJ, Schaeffer DA, Hendricks TR, Bennett D, Chaum E, Simpson JT. Structural Manipulation
`of Microcone Arrays for Microsurgical Modification of Ophthalmic Tissues. J. Med. Devices. July 2014;
`8(3):034558.
`61. Rainey F, Kivlehan F, Chaum E, Lindner E. Toward Feedback Controlled Anesthesia: Automated
`Flow Analytical System for Electrochemical Monitoring of Propofol in Serum Solutions.
`Electroanalysis, 2014, 26:1295 – 1303.
`62. Adal KM, Sidibé D, Ali S, Chaum E, Karnowski TP, Mériaudeau F. Automated detection of
`microaneurysms using scale-adapted blob analysis and semi-supervised learning. Comput Methods
`Programs Biomed. 2014 Apr;114(1):1-10.
`63. Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B,
`Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan
`KC, Maniatis T, Taylor JP. (2014) Axonal transport of TDP-43 mRNA granules is impaired by ALS-
`causing mutations. Neuron. Feb 5;81(3):536-43.
`64. Yin, J, Winborn, C.S., Thomas, F., Tran, Q.T., Lang, J.C. and Chaum, E. Modulation of Oxidative
`Stress Responses by Vitamin E, or Vitamin A plus Vitamin C Treatment in Human Retinal Pigment
`Epithelial Cells. Natural Science, 2015:7:558-570.
`65. Senter K, Sukumar SR, Patton RM, Chaum E. Using Clinical Data, Hypothesis Generation Tools
`and PubMed Trends to Discover the Association between Diabetic Retinopathy and Anti-hypertensive
`Drugs”, in the Proc. of the Workshop on Mining Big Data to Improve Clinical Effectiveness in
`conjunction with the IEEE Conference on Big Data, (2015)pp. 2366-2370.
`66. Chaum E, Winborn CS, Bhattacharya S. Genomic regulation of senescence and innate immunity
`signaling in the retinal pigment epithelium. Human Genome, 2015; 26:210-221.
`67. Kivlehan F, Chaum E, Lindner E. Propofol Detection and Quantification in Human Blood: The
`Promise of Feedback Controlled, Closed-loop Anesthesia. Analyst, 2015;140(1):98-106.
`68. Myers MH, Li Y, Kivlehan F, Lindner E, Chaum E. A Feedback Control Approach to Organic Drug
`Infusions Using Electrochemical Measurement. IEEE Trans Biomed Engineer. 2016 Mar;63(3):506-11.
`69. Chaum E, Huddleston S, Mastellone J. Nasal Hemiretinal Vein Occlusion. Ophthalmology. 2016,
`Feb. 123(2):399.
`70. Huo W, Zhao G, Yin J, Ouyang X, Wang Y, Yang C, Wang B, Dong P, Wang Z, Watari H, Chaum
`E, Pfeffer LM, Yue J. Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the
`epithelial to mesenchymal transition in ovarian cancer cells. J Cancer 2017; 8(1):57-64.
`71. Toutounchian JJ, Pagadala J, Miller DD, Baudry J, Park F, Chaum E, Yates CR. Novel small
`molecule JP-153 targets the Src-FAK-paxillin signaling complex to inhibit VEGF-induced retinal
`angiogenesis. Mol Pharmacol. 2017 Jan;91(1):1-13. Journal Cover Article.
`72. Bhattacharya S, Yin J, Winborn CS, Zhang Q, Yue J, Chaum E. Prominin-1 is a Novel Regulator of
`Autophagy in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2017;58(4):2366-2387.
`73. Bhattacharya S, Gangaraju R, Chaum E. Recent Advances in Retinal Stem Cell Therapy. Curr Mol
`Biol Rep. 2017 Sep;3(3):172-182.
`74. Zhang P, Zhao G, Ji L, Yin J, Lu L, Li W, Zhou G, Chaum E, Yue J. Knockdown of survivin results
`in inhibition of epithelial to mesenchymal transition in retinal pigment epithelial cells by attenuating the
`TGFβ pathway. Biochem Biophys Res Commun. 2018 Apr 6;498(3):573-578.
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`75. Stebbins K, Kieltyka S, Chaum E. Follow-Up Compliance for Patients Diagnosed with Diabetic
`Retinopathy After Teleretinal Imaging in Primary Care. Telemed J E Health. 2020 Jun 15. doi:
`10.1089/tmj.2019.0264.
`76. Chaum E. Detection of Lipemia Retinalis During Telemedical Diabetic Retinopathy Screening.
`Ophthalmology. 2020 Jul;127(7):900. doi: 10.1016/j.ophtha.2020.03.016. PMID: 32564813
`77. Lindner L, Guzinski M, Pendley B, Chaum E. Plasticized PVC Membrane Modified Electrodes:
`Voltammetry of Highly Hydrophobic Compounds. Membranes, Membranes 2020, 10(9), 202.
`78. Ocran C, Chaum E, Sobel RK. Vaping May Be Hazardous to Your Eye. Ophthalmology. 2020
`Dec;127(12):1756.
`79. Chaum E. Preclinical Studies of a Novel Microfabricated Device to Treat Corneal Epithelial
`Disease. Cornea. 2021, 40(1):48-53. PMID: 32769679
`80. Chaum E, Lindner E. A “Smart” Biosensor Catheter and Platform for Dynamic Delivery of Propofol
`to “Close the Loop" on Total Intravenous Anesthesia. Military Medicine, Volume 186, Issue
`Supplement_1, January-February 2021, Pages 370–377, https://doi.org/10.1093/milmed/usaa470
`81. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif, M, et al. Guidelines for the use and
`interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Feb 8:1-382. doi:
`10.1080/15548627.2020.1797280.
`82. Guzinski M, Lindner E, Pendley B, Chaum E. Polymeric membrane-modified voltammetric sensors
`for lipophilic analytes with nanomolar detection limit: Key parameters influencing the response
`characteristics. Anal Chim Acta. 2021 Aug 1;1171:338642.
`83. Madadi, Y., Seydi, V., Sun, J., Chaum, E., Yousefi, S. Stacking Ensemble Learning in Deep Domain
`Adaptation for Ophthalmic Image Classification Lecture Notes in Computer Science. 2021, 12970
`LNCS, pp. 168–178.
`84. Guzinski M, Lindner E, Pendley B, Chaum E. Electrochemical sensor for tricyclic antidepressants
`with low nanomolar detection limit: Quantitative Determination of Amitriptyline and Nortriptyline in
`blood. Talanta. 2022 Mar 1;239:123072. doi: 10.1016/j.talanta.2021.123072.
`85. Bhattacharya S, Yin J, Huo W, Chaum E. Modeling of mitochondrial bioenergetics and autophagy
`impairment in MELAS-mutant iPSC-derived retinal pigment epithelial cells. Stem Cell Research &
`Therapy. SCRT-D-21-01585. Accepted for publication, April 30, 2022.
`86. Bhattacharya S, Yin J, Yang CH, Wang Y, Sims MM, Pfeffer LM, Chaum E. STAT3 suppresses the
`AMPKalpha-ULK1-dependent induction of autophagy in glioblastoma cells. Journal of Cellular and
`Molecular Medicine. JCMM-01-2022-056. Accepted for publication May 19, 2022.
`
`
`B. Clinical trials manuscripts; DCCT/EDIC Research Group, AREDS2, DRCR Network, others)
`Shaikh, S., Capone, A., Schwartz, S.D., Gonzales, C., Trese, M.T. for the ROP Photographic
`1.
`Screening Trial (Photo-ROP) Study Group. (2003) Inadvertant skip areas in treatment of Zone 1
`retinopathy of prematurity. Retina 23:128-131.
`2. A. Boright, A. Paterson, L. Mirea, S. Bull, S. Scherer, B. Zinman, and the DCCT/EDIC Research
`Group (2005). Genetic Variation at the ACE Gene is associated with persistent Microalbuminuria and
`severe Nephropathy in type 1 diabetes. The DCCT/EDIC Genetics Study. Diabetes, 54:1238-1244.
`3. M. Steffes, P. Cleary, D. Goldstein, R. Little, H. M. Wiedmeyer, C. Rohlfing, J. England, J.
`Bucksa, M. Nowicki and the DCCT/EDIC Research Group (2005). Glycated Hemoglobin (HbA1c)
`Measurements Over Nearly Two Decades: Sustaining Comparable Values throughout the Diabetes
`Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications
`Study. Clinical Chemistry, 51:753-758.
`(DCCT/EDIC) Study Research Group (2005). Intensive Diabetes Treatment and Cardiovascular
`4.
`Disease in Patients with Type 1 Diabetes. New England Journal of Medicine, 353:2643-2653.
`
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`S. Genuth, W. Sun, O. Bautista, P. Cleary, D. Sell, W. Dahms, J. Malone, W. Sivitz, V.M. Monnier
`5.
`and the DCCT Skin Collagen Ancillary Study Group and the (DCCT/EDIC) Study Research Group
`(2005). Glycation and Carboxymethyllysine Levels in Skin Collagen Predict the Risk of Future 10-Year
`Progression of Retinopathy and Nephropathy in the Diabetes Control and Complications Trial and
`Epidemiology of Diabetes Interventions and Complications Participants with Type 1 Diabetes. Diabetes,
`54:3103-3111.
`S.D. Sibley, W. Thomas, I. de Boer, J.D. Brunzell, M.W. Steffes, and the DCCT/EDIC Research
`6.
`Group (2006). Gender and elevated albumin excretion in the Diabetes Control and Complications
`Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Cohort: Role of central
`obesity. American Journal of Kidney Diseases, 47:223-232.
`P.A. Cleary, T.J. Orchard, S.Genuth, N.D. Wong, R. Detrano, J.Y. Backlund, B. Zinman, A.M.
`7.
`Jacobson, W. Sun, J.M. Lachin, D.M. Nathan and the (DCCT/EDIC) Study Research Group (2006). The
`Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants
`of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and
`Complications (DCCT/EDIC) Study. Diabetes, 55:3556-3565.
`8. C.L. Martin, J. Albers, W.H. Herman, P.A. Cleary, B. Waberski, D.A. Greene, M.J. Stevens, and
`E.L. Feldman and the (DCCT/EDIC) Study Research Group (2006). Neuropathy among the Diabetes
`Control and Complications Trial Cohort 8 Years after Trial Completion. Diabetes Care, 29:340-344.
`9. A.D. Paterson, B.N. Rutledge, P.A. Cleary, J.M. Lachin, R.S. Crow and the (DCCT/EDIC) Study
`Research Group (2007). The Effect of Intensive Diabetes Treatment on Resting Heart Rate in Type 1
`Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and
`Complications Study. Diabetes Care, 30:2107-2112.
`10. S.J. Murdoch, A.P. Boright, A.D. Paterson, B. Zinman, M. Steffes, P. Cleary, K. Edwards, S.
`Marcovina, J. Purnell, J. Brunzell, DCCT/EDIC Research Group (2007). LDL Composition in E2/2
`Subjects and LDL Distribution by apo E Genotype in Type 1 Diabetes. Atherosclerosis, 192:138-147.
`11. H. Al-Kateb, L. Mirea, X. Xie, L. Sun, M. Liu, H. Chen, S.B. Bull, A.P. Boright, A.D. Paterson, for
`the DCCT/EDIC Research Group (2007). Multiple variants in vascular endothelial growth factor
`(VEGFA) are risk factors for time to severe nephropathy in type 1 diabetes. Diabetes, 56:2161-2168.
`I.H. d