I 1111111111111111 1111111111 11111 1111111111 111111111111111 lll111111111111111
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`USO 11510625B2
`
`(12) United States Patent
`Gray et al.
`
`(IO) Patent No.: US 11,510,625 B2
`(45) Date of Patent:
`*Nov. 29, 2022
`
`(54) TRANSCUTANEOUS ANALYTE SENSORS,
`APPLICATORS THEREFOR, AND
`ASSOCIATED METHODS
`
`(71) Applicant: DexCom, Inc., San Diego, CA (US)
`
`(72)
`
`Inventors: John Michael Gray, San Diego, CA
`(US); Jennifer Blackwell, San Diego,
`CA (US); Paul V. Neale, San Diego,
`CA (US); Justen Deering England,
`San Francisco, CA (US); Andrew
`Joncich, Madison, WI (US); Cameron
`Brock, San Francisco, CA (US); Peter
`C. Simpson, Cardiff by the Sea, CA
`(US); Thomas Metzmaker, San Diego,
`CA (US); Neel Narayan Shah,
`Carlsbad, CA (US); Mark Douglas
`Kempkey, Vista, CA (US); Patrick
`John Castagna, San Diego, CA (US);
`Warren Terry, Poway, CA (US); Jason
`Halac, San Diego, CA (US); Christian
`Michael Andre George, San Diego,
`CA (US); Daniel E. Apacible, Chula
`Vista, CA (US); John Charles Barry,
`San Diego, CA (US); Maria Noel
`Brown Wells, Vista, CA (US); Kenneth
`Pirondini, San Diego, CA (US);
`Andrew Michael Reinhardt, Santee,
`CA (US); Jason C. Wong, San Diego,
`CA (US); Remy E. Gagnon, San
`Diego, CA (US); David DeRenzy, San
`Diego, CA (US); Randall Scott Koplin,
`San Diego, CA (US); Alan Baldwin,
`San Jose, CA (US); Young Woo Lee,
`San Diego, CA (US); David A. Keller,
`Encinitas, CA (US); Louise Emma van
`den Heuvel, Somerville, MA (US);
`Carol Wood Sutherland, Somerville,
`MA (US)
`
`(73) Assignee: DexCom, Inc., San Diego, CA (US)
`
`( *) Notice:
`
`Subject to any disclaimer, the term ofthis
`patent is extended or adjusted under 35
`
`7150·~
`
`U.S.C. 154(b) by O days.
`
`This patent is subject to a terminal dis(cid:173)
`claimer.
`
`(21) Appl. No.: 17/592,170
`
`(22) Filed:
`
`Feb. 3, 2022
`
`(65)
`
`Prior Publication Data
`
`US 2022/0151562 Al May 19, 2022
`
`Related U.S. Application Data
`
`(63) Continuation of application No. 17/378,146, filed on
`Jul. 16, 2021, now Pat. No. 11,311,241, which is a
`(Continued)
`
`(51)
`
`(2006.01)
`(2006.01)
`(2006.01)
`
`Int. Cl.
`A61B 51145
`A61B 511473
`A61B 5100
`(52) U.S. Cl.
`CPC .......... A61B 516849 (2013.01); A61B 510004
`(2013.01); A61B 5114503 (2013.01);
`(Continued)
`(58) Field of Classification Search
`CPC . A61B 5/6849; A61B 5/0004; A61B 5/14503;
`A61B 5/14532; A61B 5/14546;
`(Continued)
`
`(56)
`
`References Cited
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`FOREIGN PATENT DOCUMENTS
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`(Continued)
`
`Abbott Ex. 1001 - 1/142
`
`

`

`US 11,510,625 B2
`Page 2
`
`OTHER PUBLICATIONS
`
`US 8,027,708 Bl, 09/2011, Shults et al. (withdrawn)
`(Continued)
`
`Primary Examiner - Navin Natnithithadha
`(74) Attorney, Agent, or Firm - Snell & Wilmer LLP
`
`ABSTRACT
`(57)
`The present embodiments relate generally to applicators of
`on-skin sensor assemblies for measuring an analyte in a host,
`as well as their method of use and manufacture. In some
`aspects, an applicator for applying an on-skin sensor assem(cid:173)
`bly to a skin of a host is provided. The applicator includes
`an applicator housing, a needle carrier assembly comprising
`an insertion element configured to insert a sensor of the
`on-skin sensor assembly into the skin of the host, a holder
`releasably coupled to the needle carrier assembly and con(cid:173)
`figured to guide the on-skin sensor assembly while coupled
`to the needle carrier assembly, and a drive assembly con(cid:173)
`figured to drive the insertion element from a proximal
`starting position to a distal insertion position, and from the
`distal insertion position to a proximal retraction position.
`
`30 Claims, 85 Drawing Sheets
`
`Related U.S. Application Data
`
`continuation of application No. 17 /200,664, filed on
`Mar. 12, 2021, now Pat. No. 11,207,026, which is a
`continuation of application No. 16/016,493, filed on
`Jun. 22, 2018, now Pat. No. 11,311,240, which is a
`continuation of application No. 16/016,354, filed on
`Jun. 22, 2018, now Pat. No. 10,863,944.
`(60) Provisional application No. 62/658,486, filed on Apr.
`16, 2018, provisional application No. 62/524,247,
`filed on Jun. 23, 201 7.
`
`(52) U.S. Cl.
`CPC ...... A61B 5114532 (2013.01); A61B 5114546
`(2013.01); A61B 516833 (2013.01); A61B
`516848 (2013.01); A61B 5/1473 (2013.01);
`A61B 2560/063 (2013.01)
`( 58) Field of Classification Search
`CPC ... A61B 5/6833; A61B 5/6848; A61B 5/1473;
`A61B 2560/063; A61B 5/68335; A61B
`5/0002; A61B 5/05; A61B 5/1411; A61B
`5/14507; A61B 5/14514; A61B 5/14735;
`A61B 5/1486; A61B 5/14865; A61B
`5/1495; A61B 5/6801; A61B 5/72; A61B
`17/3468; A61B 5/14; A61B 5/145; A61B
`5/1468; A61B 5/150022; A61B
`2017/3492; A61B 2560/0223; A61B
`2560/045; A61B 2562/18; Y02A 90/26;
`A61M 5/14244; A61M 5/1723; A61M
`2005/1585
`USPC .......................................... 600/309, 345-366
`See application file for complete search history.
`
`(56)
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`Abbott Ex. 1001 - 6/142
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`US 11,510,625 B2
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