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`ADDRESS
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`BIRTH DATE
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`NATIONALITY
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`EDUCATION
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`CURRICULUM VITAE
`
`Sabee Molloi, Ph.D.
`
`1378 Terrace Way (Home)
`Laguna Beach, CA 92651
`(949) 494-3778
`
`University of California (Office)
`School of Medicine
`Department of Radiological Sciences
`Medical Sciences I, B-140
`Irvine, CA 92697
`(949) 824-5904
`
`July 10, 1958
`
`Citizen, U.S.A.
`
`Minnesota State University
`Mankato, Minnesota
`
`BS Degree, 1980
`Chemistry and Physics
`
`University of Wisconsin
`Madison, Wisconsin
`MS Degree, 1985
`Medical Physics
`
`University of Wisconsin
`Madison, Wisconsin
`Ph.D. Degree, 1987
`Medical Physics
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`Thesis: "Dynamic Dual-Energy Techniques for
`Cardiac Imaging"
`
`Research Advisor: Professor Charles A. Mistretta
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`RESEARCH AND PROFESSIONAL EXPERIENCE
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`1978-1980
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`Research Assistant, Atomic Physics, Minnesota State
`University
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`1979-1980
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`1980-1981
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`1982-1983
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`1983-1987
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`1987-1988
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`1988-1989
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`1989-1991
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`1991-1995
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`1991-1996
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`1995-2002
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`1995-2002
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`1998-2002
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`2000-2002
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`2002-2004
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`2002-2004
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`2002-2004
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`Research Assistant, Atomic Absorption
`Spectroscopy, Minnesota State University
`
`Research Assistant, High Energy Physics,
`University of Minnesota
`
`Research Assistant, Nuclear Medicine,
`University of Wisconsin
`
`Research Assistant, Medical Physics
`(DSA), University of Wisconsin
`
`
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`Research Associate, Medical Physics (DSA),
`University of Wisconsin
`
`Assistant Researcher, Radiological Sciences,
`University of California-Irvine
`
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`Assistant Adjunct Professor, Radiological Sciences,
`University of California-Irvine
`
`
`Assistant Professor in Residence, Radiological
`Sciences and Medicine (Cardiology), University of
`California-Irvine
`
`Graduate Program Director, Radiological
`Sciences, University of California-Irvine
`
`
`
`Associate Professor in Residence, Radiological
`Sciences, University of California-Irvine
`
`
`
`
`
`Associate Professor in Residence, Medicine (Cardiology),
`University of California-Irvine
`
`Associate Professor in Residence, Electrical and Computer
`Engineering, University of California-Irvine
`
`Associate Professor in Residence, Center for Biomedical
`Engineering, University of California-Irvine
`
`Associate Professor, Radiological Sciences, University of
`California-Irvine
`
`Associate Professor, Medicine (Cardiology), University of
`California-Irvine
`
`Associate Professor, Electrical Engineering and Computer
`Sciences, University of California-Irvine
`
`2
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`2002-2004
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`2004-present
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`2004-present
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`2004-present
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`2004-present
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`2011-present
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`Associate Professor, Biomedical Engineering, University of
`California-Irvine
`
`Professor, Radiological Sciences, University of California-
`Irvine
`
`Professor, Medicine (Cardiology), University of California-
`Irvine
`
`Professor, Electrical Engineering and Computer Sciences,
`University of California-Irvine
`
`Professor, Biomedical Engineering, University of
`California-Irvine
`
`Vice Chairman of Research, Radiological Sciences,
`University of California-Irvine
`
`
`HONORS
`
`1979 Mathematics Scholarship Award, Minnesota State University, Mankato, Minnesota
`1980 American Chemical Society Award, Minnesota State University, Mankato, Minnesota
`1980 Outstanding Senior Award, Minnesota State University, Mankato, Minnesota
`1980 Magna cum Laude Award, Minnesota State University, Mankato, Minnesota
`1997 American Heart Association Established Investigator Award
`2010 Fellow of the American Association of Physics in Medicine (AAPM)
`2014 Distinguished Investigator of the Academy of Radiology Research
`2015 Fellow of the American Institute for Medical and Biological Engineering (AIMBE)
`
`PROFESSIONAL SOCIETIES MEMBERSHIP
`
`American Association of Physicists in Medicine
`International Society for Optical Engineering
`Elected member of Western Association of Physicians
`American Heart Association
`
`INSTITUTIONAL SERVICE
`
`
`Department of Radiological Sciences
`
`1991-1996 Director, Graduate Program, Department of Radiological Sciences,
`
`
`UC-Irvine
`
`1991-1996
`
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`Chairman, Graduate Program Committee, Department of Radiological Sciences,
`UC-Irvine
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`1997-Present Member, Merits and Promotion Committee, Department of Radiological
`Sciences,
`
`UC-Irvine
`
`2000-2009 Member, Resident Education Committee, Department of Radiological Sciences,
`UC-Irvine
`
`
`2000-2011 Member, Clinical Research Committee, Department of Radiological Sciences,
`UC-Irvine
`
`2012-present Chairman, Research Committee, Department of Radiological Sciences,
`UC-Irvine
`
`
`School of Medicine
`
`1989-1991 Member, Medical School Interview Committee, College of Medicine, UC-Irvine
`
`1993
`
`Member, Search Committee for Associate Dean of Faculty Development, UC-
`Irvine
`
`
`1992-2007 Member, M.D./Ph.D. Admission Committee, College of Medicine, UC-Irvine
`
`1997-2002 Member, College of Medicine Graduate Academic Programs Committee, College
`of Medicine, UC-Irvine
`
`
`1997-Present Member, Cancer Center, School of Medicine, UC-Irvine
`
`1999-2002
`
`Chairman, College of Medicine Graduate Academic Programs Committee,
`College of Medicine, UC-Irvine
`
`
`1999-2008 Member, College of Medicine Senate Executive Committee, College of Medicine,
`UC-Irvine
`
`
`2001
`
`
`2001
`
`Member, LCME Task Force on Graduate Basic Science Education, College of
`Medicine, UC-Irvine
`
`Chairman, Ad Hoc Committee on Promotion and Honor Hearing, College of
`Medicine, UC-Irvine
`
`
`2002-2005 Member, Research and Graduate Academic Programs Committee, College of
`Medicine, UC-Irvine
`
`
`2003-2005
`
`
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`2006
`
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`Chairman, Research and Graduate Academic Programs Committee, College of
`Medicine, UC-Irvine
`
`Member, Search Committee for Chair of Department of Radiological Sciences,
`School of Medicine, UC-Irvine
`
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`2006-2009 Member, School of Medicine Senate Mentor Committee, School of Medicine,
`UC-Irvine
`
`
`2006-2008
`
`Chairman, School of Medicine Senate Mentor Committee, School of Medicine,
`UC-Irvine
`
`
`
`Member, Review Committee for Associate Dean, School of Medicine, UC-Irvine
`
`
`
`2007
`
`
`2008-present Member, M.D./Ph.D. Advisor Committee, School of Medicine, UC-Irvine
`
`2008-present Member, COHS Representative Assembly, School of Medicine, UC-Irvine
`
`2012-present Member, School of Medicine Space Resource Allocation Advisory (SRAAC)
`Committee, School of Medicine, UC-Irvine
`
`
`2017-present Chairman, School of Medicine Space Resource Allocation Advisory (SRAAC)
`Committee, School of Medicine, UC-Irvine
`
`
`
`
`University of California, Irvine
`
`2000-2003 Member, Biomedical Engineering Graduate Student Admission Committee,
`School of Engineering, UC-Irvine
`
`
`2003-2005 Member, BME-COM Seed Grant Committee, School of Engineering, UC-Irvine
`
`2006
`
`Member, Search Committee for Director and Attending Veterinarian University
`Laboratory Animal Resources, UC-Irvine
`
`
`2008
`
`
`2009
`
`Member, Ad Hoc Review Committee for Committee on Academic Personnel,
`UC-Irvine
`
`Member, Search Committee for Director of Edwards Life Sciences Center for
`Advanced Cardiovascular Technology, School of Engineering, UC-Irvine
`
`
`2012-2013 Member, Council on Faculty Welfare, Diversity, and Academic Freedom (CFW),
`UC-Irvine
`
`
`2012-2013 Member, Imaging Task Force, UC-Irvine
`
`2014-present Member, Committee on Committee (University wide committees), UC-Irvine
`
`2014
`
`Member, Search Committee for Director of Edwards Life Sciences Center for
`Advanced Cardiovascular Technology, School of Engineering, UC-Irvine
`
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`5
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`CATHWORKS EXHIBIT 1003
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`NATIONAL SERVICE
`
`1991
`
`Member, Site Visit to Harbor-UCLA Medical Center, American Heart
`Association
`
`
`
`
`
`
`
`
`1994
`
`
`1994
`
`
`1995
`
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`1999-2002 Member, Calibration Laboratory Accreditation Subcommittee, American
`
`
`Association of Physicists in Medicine
`
`2001
`
`Member, Small Business Innovation Research (SBIR) Study Section, National
`Institutes of Health
`
`Session Chairman, American Association of Physicists in Medicine, Anaheim,
`California
`
`Session Chairman, American Association of Physicists in Medicine, Boston,
`Massachusetts
`
`Member, Small Business Innovation Research (SBIR) Mock Study Section,
`National Institutes of Health
`
`Member, Special Emphasis Study Section on low cost medical imaging devices,
`National Institutes of Health
`
`Member, Special Emphasis Study Section on medical imaging technologies,
`National Institutes of Health
`
`Member, Biomedical Imaging Research Subcommittee, American Association of
`Physicists in Medicine
`
`Member, Diagnostic X-Ray Imaging Subcommittee, American Association of
`Physicists in Medicine
`
`Member, NIH Site Visit to Center for Gamma-Ray Imaging, University of
`Arizona
`
`Member, Ph.D. thesis committee for Zhou Wang, Department of Physiology and
`Biophysics, University at Buffalo, State University of New York
`
`Member, Ph.D. thesis committee for Daryl Nazareth, Department of Physiology
`and Biophysics, University at Buffalo, State University of New York
`
`Session Moderator, American Association of Physicists in Medicine, Seattle,
`Washington
`
`
`2005-2009 Member, Radiography and Fluoroscopy Subcommittee, American Association of
`Physicists in Medicine
`
`
`2003
`
`
`2003
`
`
`2004
`
`
`2004
`
`
`2004
`
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`2004
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`2004
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`2005
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`6
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`CATHWORKS EXHIBIT 1003
`Page 6 of 42
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`2005-2008 Member, Task group No. 122- Imaging Research Opportunity Task Group
`(BIROW IV), American Association of Physicists in Medicine
`
`
`2005-2013 Member, Imaging Research Subcommittee, American Association of Physicists in
`Medicine
`
`Session Moderator, American Association of Physicists in Medicine, Orlando,
`Florida
`
`Member, Seed funding reviewer group, American Association of Physicists in
`Medicine
`
`Representing American Association of Physicists in Medicine at the National
`Academies, Committee on the State of the Science in Nuclear Medicine
`
`Session Moderator, American Association of Physicists in Medicine,
`Minneapolis, Minnesota
`
`Session Moderator, American Association of Physicists in Medicine, Houston,
`Texas
`
`Co-Chair, Seed funding reviewer group, American Association of Physicists in
`Medicine
`
`Imaging Scientific Program Co-Director, Annual Meeting for American
`Association of Physicists in Medicine, Houston, Texas
`
`Session Moderator, American Association of Physicists in Medicine, Anaheim,
`California
`
`Imaging Scientific Program Director, Annual Meeting for American Association
`of Physicists in Medicine, Anaheim, California
`
`Session Moderator, American Association of Physicists in Medicine, Vancouver,
`Canada
`
`Member, Special Emphasis Study Section for National Institute of Biomedical
`Imaging and Bioengineering (U01), National Institutes of Health
`
`Member, Radiology Imaging BSc Peer Review Study Group, American Heart
`Association
`
`Session Moderator, American Association of Physicists in Medicine, Austin,
`Texas
`
`Session Moderator, World Congress on Medical Physics and Biomedical
`Engineering, Toronto, Canada
`
`7
`
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`2006
`
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`2006
`
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`2006
`
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`2007
`
`
`2008
`
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`2008-2013
`
`
`2008
`
`
`2009
`
`
`2009
`
`
`2011
`
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`2013
`
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`2013
`
`
`2014
`
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`2015
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`CATHWORKS EXHIBIT 1003
`Page 7 of 42
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`2016
`
`Session Moderator, American Association of Physicists in Medicine, Washington,
`DC
`
`
`
`
`EDITORIAL BOARDS
`
`1999-2002 Guest Associate Editor, Medical Physics
`2003-2006 Associate Editor, Medical Physics
`2006-2013 Guest Associate Editor, Medical Physics
`2008-2013
`International Advisory Board, Physics in Medicine and Biology
`2014-Present Associate Editor, Medical Physics
`
`REFEREE SERVICE
`
`Medical Physics
`Physics in Medicine and Biology
`IEEE Transaction on Medical Imaging
`Circulation
`Academic Radiology
`Computers and Biomedical Research Journal
`
`AREAS OF RESEARCH INTEREST
`
`The area of research interest is the quantitative aspects of medical x-ray imaging and its
`applications to cardiac and breast imaging.
`
`
`FORMER PH.D. STUDENTS
`
`Atila Ersahin, Ph.D. in Department of Radiological Sciences (1993). Thesis Title:
`"Instantaneous Brain Blood Flow Measurements Using First Pass Distribution Analysis and
`Digital Subtraction Angiography". Current Position: Invision Technologies, San Francisco,
`California.
`
`Yifang Zhou, Ph.D. in Department of Radiological Sciences (2000). Thesis Title: “Quantitative
`Assessment of Diffuse Coronary Artery Disease Using Digital Angiography”. Current position:
`Medical Physicist, Cedars-Sinai Medical Center, Los Angeles, CA.
`
`Jerry Wong, M.D., Ph.D. in Department of Biomedical Engineering (2008). Thesis Title:
`“Quantification of Fractional Flow Reserve Using Angiographic Image Data”. Current position:
`Pathology Resident, University of Chicago, Chicago, Ill.
`
`Huy Quang Le, M.D., Ph.D. in Department of Biomedical Engineering (2011). Thesis Title:
`“Breast Computed Tomography Using CdZnTe Detectors”. Current position: Radiology
`Resident, Kaiser Permanente, Irvine, CA.
`
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`
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`Justin Ducote, Ph.D. in Department of Biomedical Engineering (2011). Thesis Title: “Dual
`Energy Methods for Quantifying Breast Density”. Current position: Medical Physicist Orange
`County CyberKnife and Radiation Oncology Center, Fountain Valley, CA.
`
`
`
`JUNIOR FACULTIES
`
`2003-2007
`Polad Shikhaliev, Ph.D.
`Current position: Assistant Professor of Physics, Louisiana State University, Baton Rouge, LA.
`
`2003-2006
`
`Tong Xu, Ph.D.
`Current position: Associate Professor of Physics, Carleton University, Ottawa, ON, Canada.
`
`2014-present
`Huanjun Ding, Ph.D.
`Current position: Assistant Adjunct Professor of Radiological Sciences, University of California-
`Irvine.
`
`
`POSTDOCTORAL FELLOWS
`
`1990-1992
`
`Yao-Jin Qian, Ph.D.
`Current position: Clinical Medical Physicist, Kaiser Permanente, Irvine, CA.
`
`1991-1995
`
`Xian Lao, M.D.
`Current position: Staff Research Associate, University of California, Irvine, CA.
`
`
`
`1993-1994
`Greg Bednarz, Ph.D.
`Current position: Associate Professor, University of Pittsburgh Medical Center, Pittsburgh, PA.
`
`Jerry Tang, Ph.D.
`
`Martin Marcin, Ph.D.
`
`1996-1997
`Farhood Saremi, M.D.
`Current position: Professor of Radiology, University of Southern California, Los Angeles, CA.
`
`John Breault, Ph.D.
`
`Fuming Wang, Ph.D.
`
`2000-2003
`
`Tong Xu, Ph.D.
`Current position: Assistant Professor of Physics, Carleton University, Ottawa, ON, Canada.
`
`2001-2003
`Polad Shikhaliev, Ph.D.
`Current position: Assistant Professor of Physics, Louisiana State University, Baton Rouge, LA.
`
`Reza Berenji, M.D.
`
`
`
`
`
`
`
`1994-1996
`
`1995-1996
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`1998-2000
`
`1999-2000
`
`2001-2002
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`9
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`CATHWORKS EXHIBIT 1003
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`2001-2002
`
`2009-2012
`
`2010-2014
`
`2010-2011
`
`2011-2014
`
`2012
`
`2012-2015
`
`2013-2014
`
`2013-2015
`
`2013-2015
`
`2009-2012
`
`2010-2011
`
`2009-2011
`
`2010-2011
`
`2014-2016
`
`2014-2015
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Current position: Assistant Professor of Nuclear Medicine, VA Greater LA Healthcare, Los
`Angeles, CA.
`
`Zickuan Chen, Ph.D.
`
`Yahya Alivov, Ph.D.
`
`Huanjun Ding, Ph.D.
`
`Pavlo Baturin, Ph.D.
`
`Bo Zhao, Ph.D.
`
`Bijan Berenji, Ph.D.
`
`Hyo-Min Cho, Ph.D.
`
`Benjamin Ziemer, Ph.D.
`
`Bahman Sadeghi, M.D.
`
`Hanna Javan, M.D.
`
`
`MD/Ph.D. STUDENTS
`
`2002-2010
`Jerry Wong, M.D., Ph.D.
`Huy Quang Le, M.D., Ph.D. 2003-2011
`Logan Hubbard
`
`2014-present
`
`GRADUATE STUDENTS
`
`Michael Klopfer
`
`Farnaz Behroozi
`
`Zhang Zhang
`
`Tom Wolowiec
`
`Nikita Kumar
`
`David Sennug
`
`Yixiao Zhou
`
`RESIDENTS
`
`Ravi Ramsamooj, M.D.
`
`
`
`
`
`2016-present
`
`2000-2001
`
`
`
`10
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`1992-1993
`1998-2000
`1999-2000
`2001-2002
`
`
`
`UNDERGRADUATE HONORS RESEARCH PROGRAM
`
`
`Setareh Aria
`Quang Thanh Dang
`Huy Quang Le
`Trien Dang
`
`
`
`TEACHING
`
`1980-1982 University of Minnesota (Teaching Associate), Undergraduate Physics
`Laboratory
`
`1988-1989 University of California-Irvine, Radiological Sciences
`Basic Lecture Series for Residents, Physics of Diagnostic Radiology - lectures on
`Digital Radiography and Computer Applications in Radiology
`
`1990
`
`
`
`
`1989-1990 University of California-Irvine, Radiological Sciences
`201A, Fundamentals of Imaging Physics, Lectures on Principles of Medical x-ray
`Imaging
`
`University of California-Irvine, Radiological Sciences
`290, Seminars in Medical Imaging, Organization of the Spring Lecture Series
`
`
`1988-1996 University of California-Irvine, Radiological Sciences
`
`
`260A, Principles of Medical X-ray Imaging
`
`1990-2009 University of California-Irvine, Radiological Sciences
`
`
`Basic Science Lecture Series for Residents, Physics of
`
`
`Diagnostic Radiology, Course Director
`
`1990-2011 University of California-Irvine, Radiological Sciences
`
`
`Basic Science Lecture Series for Residents, Physics of
`
`
`Diagnostic Radiology
`
`1995
`
`University of California-Los Angeles, Physics
`269B, Advanced Medical and Biomolecular Imaging “Quantitative dual-energy
`cardiac imaging”
`
`
`1995-1996 University of California-Irvine, Radiological Sciences
`290, Seminars in Medical Imaging, Organization of the Lecture Series
`
`
`1996-1998 University of California-Irvine, Radiological Sciences
`201B and Physics 147B, Biomedical Physics
`
`
`1999-2000 University of California-Irvine, Medicine
`500, Anatomy-Radiology correlates for first year medical students
`
`
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`2002
`
`
`2003
`
`University of California-Irvine, Engineering
`195/295, Introduction to Biomedical Engineering “X-ray imaging physics”
`
`University of California-Irvine, Biomedical Engineering
`195/295, Introduction to Biomedical Engineering “Introduction to medical
`imaging”
`
`
`
`INVITED PRESENTATIONS
`
`The National Heart, Lung, and Blood Institute
`National Institutes of Health
`
`
`
`
`
`
`
`
`
`
`Saint John's Cardiovascular Research Institutes
`Harbor - UCLA
`
`
`
`
`Department of Radiology
`Thomas Jefferson Medical College
`
`
`
`
`
`
`
`The National Heart, Lung, and Blood Institute
`National Institutes of Health
`
`
`Biomedical Engineering Society
`
`
`
`Department of Physics
`University of California Los Angeles
`
`
`American Association of Physicists in Medicine
`
`
`Department of Medicine, Division of Cardiology
`
`
`
`Department of Medicine, Division of Cardiology
`
`
`
`
`
`12
`
`
`
`
`
`
`
`Quantitative coronary
`angiography by dual-energy DSA
`1990
`
`Quantification of absolute coronary
`blood flow and coronary calcium
`using dual-energy fluoroscopy.
`1992
`
`Quantitative techniques in dual-
`energy digital subtraction
`angiography.
`1992
`
`Absolute coronary blood flow
`measurement by dual-energy DSA.
`1993
`
`Volumetric blood flow measurement
`using dual-energy DSA and first pass
`distribution analysis.
`1994
`
`Quantitative dual-energy cardiac
`imaging.
`1995
`
`Digital angiographic imaging
`1998
`
`Regional flow measurement by
`digital subtraction angiography
`1999
`
`Quantitative angiographic
`assessment of coronary artery
`disease
`2005
`
`CATHWORKS EXHIBIT 1003
`Page 12 of 42
`
`

`

`
`Susan Samueli Center for Integrative Medicine, UCI
`
`
`Joint Grand Rounds with Departments of
`Neurosurgery and Neurology, State University
`of New York at Buffalo
`
`Toshiba Stroke Research Center, State University
`of New York at Buffalo
`
`
`
`Susan Samueli Center for Integrative Medicine, UCI
`
`Peking University Medical School, Beijing, China
`
`Northeastern University, Sino-Dutch Biomedical
` and Information Engineering School, Shenyang,
` China
`
`Xian University, School of Biomedical Engineering,
`Xian, China
`
`FuWai Cardiovascular Institute and Hospital
`Peking Union Medical College Chinese Academy
`of Medical Sciences, Radiology Department
`Beijing, China
`
`American Association of Physicists in Medicine
`
`
`
`Department of Medicine, Division of Cardiology
`
`World Congress on Medical Physics
`and Biomedical Engineering
`Munich, Germany
`
`Workshop on Medical Applications
`
`
`
`13
`
`Quantitative coronary angiography
`2005
`
`Blood flow Analysis
`2005
`
`Regional volumetric blood flow
`measurement using digital
`angiography
`2005
`
`Quantitative techniques for coronary
`artery disease
`2006
`
`Quantitative aspects of cardiac x-ray
`imaging
`2007
`
`Coronary artery disease
`quantification using angiographic
`fractional flow reserve
`2007
`
`Quantitative aspects of x-ray
`imaging
`2007
`
`Quantification of fractional flow
`reserve using angiographic images
`2007
`
`Physiological assessment of
`coronary artery disease based on
`angiographic image data
`2008
`
`Fractional flow reserve measurement
`using angiographic image data
`2009
`
`Fractional flow reserve
`measurement using angiographic
`image data
`2009
`
`Breast tissue composition
`
`CATHWORKS EXHIBIT 1003
`Page 13 of 42
`
`

`

`of Spectroscopic X-ray Detectors
`Geneva, Switzerland (CERN)
`
`
`The 1st MEFOMP International
`Conference of Medical Physics
`Shiraz, Iran
`
`
`European Congress of Radiology
`Satellite Symposia
`Vienna, Austria
`
`American Association of Physicists in Medicine
`
`
`
`American Association of Physicists in Medicine
`
`
`
`American Association of Physicists in Medicine
`
`
`
`measurement with a spectral
`computed tomography system
`2011
`
`Breast density measurement
`using dual-energy mammography
`2011
`
`
`Breast density measurement-
`risk assessment in screening
`2012
`
`Dual-energy mammography imaging
`and applications
`2014
`
`Spectral Mammography Based on
`Photon Counting Detectors
`2015
`
`Photon-Counting Detectors in
`Mammographic Imaging
`2017
`
`
`
`
`GRANT SUPPORT
`
`
`
`
`
`
`
`
`
`1989-1994 National Institutes of Health (R29 HL 42435)
`
`
`(Quantitative Coronary Angiography
`
`
`by Dual Energy DSA)
`PI: S. Molloi
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Total costs
`$510,000
`
`$12,000
`
`$3,200
`
`$730,000
`
`$710,000
`
`
`
`
`
`
`
`
`1990-1991 Alliance Pharmaceutical Corporation
`
`
`(Utilization of PFOB as a Contrast Agent
`
`
`in Dual Energy DSA)
`PI: S. Molloi
`
`
`
`Irvine Research Foundation
`(CCD Application for Dual Energy DSA)
`PI: S. Molloi
`
`
`1990-1991
`
`
`
`
`
`
`1991-1994 National Institutes of Health
`
`
`(Intravascular Ultrasound Imaging of
`
`
`Atherosclerosis)
`PI: J. Tobis
`
`
`1992-1997 National Institutes of Health (R01 HL 48030)
`14
`
`
`
`CATHWORKS EXHIBIT 1003
`Page 14 of 42
`
`

`

`
`
`
`
`
`
`(Absolute Phasic Coronary Flow
`Measurement by Dual-energy DSA)
`PI: S. Molloi
`
`
`
`Irvine Research Foundation
`(3-D Reconstruction using Biplane Images)
`PI: S. Molloi
`
`
`1994-1995
`
`
`
`
`
`
`1995-1998 National Institutes of Health
`
`
`(Intravascular Ultrasound Imaging of
`
`
`Atherosclerosis)
` PI: J. Tobis
`
`
`
`
`
`
`
`
`
`
`
`
`1997-2001 National Institutes of Health (R01 HL 57338)
`
`
`(Area Beam Equalization for X-ray
`
`
`Angiography)
`PI: S. Molloi
`
`
`1997-2001 National American Heart Association (96-40066N)
`
`
`Established Investigator Award
`
`
`(Quantification of Diffuse Coronary Artery
`
`
`Disease)
`PI: S. Molloi
`
`
`1999-2001 University of California-Irvine Multi-Investigator Award
`
`
`(Structural and Mechanical Remodeling of Coronary
`
`
`Veins and Retroperfusion)
`Co-PIs: S. Molloi, J. Milliken and J. Hicks
`
`
`2001-2004 National Institutes of Health (R01 HL 67159)
`
`
`(Quantification of Regional Coronary Blood Flow)
`
`
`PI: S. Molloi
`
`
`
`
`2001-2003 Medtronic, Inc. (MI 29340)
`
`(Measurement of the Human Coronary Venous System
`for Left Heart Lead Delivery and Design)
` PI: S. Molloi
`
`
`
`
`2002-2003 UC Cancer Research Coordinating Committee (CRCC 30702)
`
`(Automatic Compensation Technique for Intensity-Modulated
`Radiation Therapy)
`PI: S. Molloi
`
`Philips Medical Imaging Systems Inc
`
`$75,000
`
`(Three Dimensional Reconstruction of Coronary Arteries)
`PI: S. Molloi
`
`2002-2004
`
`
`
`
`
`
`
`
`2003-2008 National Institutes of Health (R01 EB000514)
`
`(X-ray Imaging using Edge-on Microchannel Plate Detectors)
`
`
`
`15
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`$12,500
`
`$910,000
`
`$700,000
`
`$300,000
`
`$19,928
`
`$866,913
`
`$88,222
`
`$49,966
`
`$1,008,298
`
`
`
`
`
`CATHWORKS EXHIBIT 1003
`Page 15 of 42
`
`

`

`
`
`PI: S. Molloi
`
`
`
`
`
`
`2003-2007 National Institutes of Health (R01)
`
`(Pressure and Flow-Induced Remodeling of Coronary Arteries)
`
`PI: G. Kassab
`
`$1,500,000
`
`
`
`$113,625
`
`
`
`2003-2004 US Army Medical Research (BC024643)
`
`(Automated Area Beam Equalization Mammography for Improved
`Imaging of Dense Breasts)
`PI: S. Molloi
`
`
`
`
`
`2004-2005 UCI Biomedical Engineering and College of Medicine seed grant $15,000
`
`
`(Quantification of Diffuse Coronary Artery Disease Based on
`Coronary Artery Tree Design Rules)
`PI: S. Molloi
`
`
`2005-2006 UCI Biomedical Engineering and College of Medicine seed grant $25,000
`(Quantification of Lung Tumor Motion using Dual-energy
`Fluoroscopy for Patient Specific Radiation Therapy)
`PI: S. Molloi
`
`
`2007-2009
`
`SCAI/Cordis Fellowship Program for Interventional Cardiology
`(A Non-invasive Angiographic Method of Assessing Coronary
`Lesion Physiology: Validation with CFR and FFR)
`PI: S. Molloi, William Suh (Fellow)
`
`$25,000
`
`$1,103,716
`
`$1,269,900
`
`$866,898
`
`$79,714
`
`
`$28,220
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`2007-2012 National Institutes of Health (R01HL083295)
`
`
`(Quantification of Coronary Calcium
`Mass by Dual Energy Fluoroscopy)
`PI: S. Molloi
`
`
`
`
`
`2009-2013 National Institutes of Health (R01CA136871)
`
`
`(Quantification of Breast Density using
`Dual Energy Mammography)
`PI: S. Molloi
`
`
`
`
`
`2009-2012 National Institutes of Health (R01HL089941)
`
`
`(Fractional Flow Reserve Measurement Based
`on Coronary Angiographic Images)
`PI: S. Molloi
`
`
`
`
`
`2009-2010 National Institutes of Health (1F31EB009630)
`
`
`(Low Dose Breast Computed Tomography
`With Photon Counting Detector)
`PI: S. Molloi, Huy Le (Fellow)
`
`
`
`
`
`
`
`
`
`Philips Medical systems
`
`(Breast Density Scoring of Spectral Images)
`PI: S. Molloi
`
`
`
`
`2013-2014
`
`
`
`
`
`
`
`16
`
`CATHWORKS EXHIBIT 1003
`Page 16 of 42
`
`

`

`2011-2017 National Institutes of Health (R01HL106043)
`
`
`(Multiethnic Study of Breast Arterial Calcium
`
`
`Gradation and CVD)
`
`
`PIs: C. Iribarren and S. Molloi
`
`2013-2017
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Toshiba Medical systems
`(Noninvasive Quantification of Fractional Flow
`Reserve Using Cardiac Computed Tomography)
`PI: S. Molloi
`
`
`
`
`
`
`
`
`Philips Medical systems
`(Quantitative Analysis of Spectral Mammography Images)
`PI: S. Molloi
`
`
`
`2014-2016
`
`
`
`
`
`2015-2017 National Institutes of Health (R43HL123186)
`
`
`(Valvuloplasty Sizing Balloon Catheter)
`
`
`PIs: G. Kassab and S. Molloi
`
`2016-2017
`
`
`
`
`
`Toshiba Medical systems
`(Quantification of regional pulmonary
`perfusion using computed tomography)
`PI: S. Molloi
`
`
`
`
`
`
`
`
`
`
`2015-2019 National Institutes of Health
`(pending)
`(Quantitative Imaging to Evaluate Response to Cancer Therapy)
`
`
`PI: S. Molloi
`
`
`2015-2019 National Institutes of Health
`(pending)
`(Breast lesion characterization using
`low-dose spectral mammography)
`PI: S. Molloi
`
`$6,894,493
`
`$141,530
`
`$218,250
`
`$237,021
`
`$118,174
`
`$2,400,000
`
`$1,541,185
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`2015-2019 National Institutes of Health
`(pending)
`(Myocardial perfusion imaging by low-dose CT)
`
`
`PI: S. Molloi
`
`PATENTS
`
`Molloi S, Tang J: Automatic x-ray beam equalizer. US Patent No. US05778046, 1998.
`
`Molloi S, Tang J: Automatic x-ray beam equalizer. US Patent No. US05881127, 1999.
`
`Xu T, Molloi S, Wong J: Real-time tracking of tumor position using implanted emission markers
`(peTrack) during radiation therapy. UC case No. 2006-362-1.
`
`Molloi S, Alivov Y: TiO2 nanotubes - a new cold cathode for X-ray generation. UC case No.
`2010-608-1.
`
`
`
`
`
`
`$1,504,473
`
`
`
`17
`
`CATHWORKS EXHIBIT 1003
`Page 17 of 42
`
`

`

`
`
`
`
`
`
`Fischer DA-100 Image Processor
`(Donated by Digital Imaging Associates)
`
`Transvascular Inc.
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`$40,000
`
`$20,000
`
`Molloi S, Klopfer M: Dynamic brachytherapy with miniature pyroelectric sources. UC case No.
`2010-1.
`
`DONATIONS
`
`1990
`
`
`2001
`
`
`PUBLICATIONS
`
`Peer - Reviewed Journals
`
`
`J-1.
`
`1987
`Light MC, Molloi SY, Yandow DR, Ranallo FN: "Scatter radiation exposure during knee
`arthrography”. Radiology 164:867-868, 1987.
`
`
`J-2. Van Lysel MS, Ergun DL, Miller WP, Toggart EJ, Cusma JT, Peppler WW, Molloi S,
`Mistretta CA: "Cardiac digital angiography and dual-energy subtraction imaging: current
`and future trends". Amer J Cardiac Imaging, 1:254-256, 1987.
`
`
`
`1988
`J-3. Molloi SY, Mistretta CA: "Scatter-glare corrections in quantitative dual-energy
`fluoroscopy". Medical Physics 15(3): 289-297, 1988.
`
`
`
`
`1989
`J-4. Molloi S, Mazess R, Bendsen H, Wilson M: "Whole body and regional retention
`of 99m Tc-labeled diphosphonates with whole-body counter: A study with
`
`normal males". Calcif Tissue Int. 44:322-329, 1989.
`
`
`J-5. Molloi SY, Mistretta CA: "Quantification techniques for dual-energy cardiac imaging".
`Medical Physics 16(2):209-217, 1989.
`
`
`
`1990
`J-6. Molloi SY, Weber DM, Peppler WW, Folts JD, Mistretta CA: "Quantitative dual-energy
`coronary arteriography". Invest Radiol, 25:908-914, 1990.
`
`
`
`1991
`J-7. Molloi S, Detrano R, Ersahin A, Roeck W, Morcos C: "Quantification of coronary
`arterial calcium by dual energy digital subtraction fluoroscopy". Medical Physics,
`18(2):295-298, 1991.
`
`
`J-8. Molloi S, Ersahin A, Roeck W, Nalcioglu O: "Absolute cross-sectional area
`measurements in quantitative coronary arteriography by dual-energy DSA". Invest
`Radiol, 26(2): 119-127, 1991.
`
`
`
`18
`
`CATHWORKS EXHIBIT 1003
`Page 18 of 42
`
`

`

`
`J-9. Weber DM, Molloi SY, Folts JD, Peppler WW, Mistretta CA: “Geometric
`
`quantitative coronary arteriography. A comparison of unsubtracted and dual-energy
`
`subtracted images”. Invest Radiol, 26(7): 649-654, 1991.
`
`
`1992
`J-10. Detrano R, Molloi S: "Radiographically detectable calcium and atherosclerosis: the
`connection and its exploitation". International Journal of Cardiovascular Imaging,
`8(3):209-215, 1992.
`
`
`
`1993
`J-11. Molloi S, Qian Y, Ersahin A, “Absolute volumetric blood flow measurements using dual-
`energy digital subtraction angiography”. Medical Physics, 20 (1): 85-91, 1993.
`
`
`
`1994
`J-12. Detrano R, Kang X, Mahaisavariya P, Tang W, Colombo A, Molloi S, Garner D,
`
`Nickerson S, "Accuracy of quantifying coronary hydroxyapatite with electron beam
`
`tomography". Invest Radiol, 29(8):733-738, 1994.
`
`J-13. Mahaisavariya P, Detrano R, Kang X, Garner D, Vo A, Georgiou D, Molloi S,
`Brundage BH, "Quantification of in vitro coronary artery calcium using ultrafast
`computed tomography". Catheterization and Cardiovascular Diagnosis, 32(4):387-393,
`1994.
`
`
`
`1995
`J-14. Molloi S, Ersahin A, Qian Y, "CCD camera for dual-energy digital subtraction
`angiography”. IEEE Transaction on Medical Imaging, 14(4):747-752, 1995.
`
`
`J-15. Ersahin A, Molloi S, Qian Y, "A digital filtration technique for Scatter-glare correction
`based on thickness estimation". IEEE Transaction on Medical Imaging, 14(3):587-595,
`1995.
`
`
`J-16. Ersahin A, Molloi S, Hicks J, “Absolute phasic blood flow measurement in the brain
`using digital subtraction angiography” Investigative Radiology, 30(4): 244-253, 1995.
`
`
`J-17. Molloi S, Ersahin A, Hicks J, Wallis J, "In-vivo validation of videodensitometric
`coronary cross-sectional area measurement using dual-energy digital subtraction
`angiography” International Journal of Cardiovascular Imaging, 11(4):223-231, 1995.
`
`
`J-18. Detrano R; Tang W; Kang X; Mahaisavariya P; McCrae M; Garner D; Peng SK;
`Measham C; Molloi S; Gutfinger D; et al., "Accurate coronary calcium phosphate mass
`measurements from electron beam computed tomograms" American Journal of Cardiac
`Imaging, 9(3):167-73, 1995.
`
`
`
`1996
`J-19. Hicks J, Ishimatsu A, Molloi S, Ersahin A, Heisler N, "The mechanism of cardiac
`shunting in reptiles: A new synopsis" Journal of Exper