`
`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`In re Application of: Klaus GIESE, et al. (cid:9)
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`Confirmation No: 6369
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`Application Serial No.: 10/633,630
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`Group Art Unit: 1635
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`Filed: August 5, 2003
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`Examiner: (cid:9)
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`Kimberly Chong
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`For: INTERFERING RNA MOLECULES
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`United States Patent and Trademark Office
`Randolph Building
`401 Dulany Street
`Alexandria, Virginia 22314
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`Declaration under 37 C.F.R. 4 1.132
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`I, Dr. Jorg Kaufmann, declare and say:
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`1.
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`I am an inventor of the captioned application..
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`2.
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`I make this declaration to explain how to calculate the number of possible ways of
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`arranging 2'- modified and unmodified nucleotides on antisense and sense strands of a double
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`stranded RNA molecule where each strand is 23 nucleotides long.
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`3.
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`In a double stranded RNA molecule of this type, any nucleotide on either strand
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`can be either modified or unmodified. In other words, there are two possibilities for each
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`position. Thus, on a single strand that is n nucleotides long, there are 2" possible ways of
`arranging modified and unmodified nucleotides on the strand. For example, each strand might
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`be completely unmodified, might have from 1 to 22 modifications arranged in any possible
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`combination of positions in the strand, or might be modified on every nucleotide.
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`On a strand containing 23 nucleotides, there are therefore 223 possible ways of
`4.
`arranging modified and unmodified nucleotides along the strand.
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`Alnylam Exh. 1061
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`1 of 2
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`(cid:9)
`(cid:9)
`
`
`Serial No. 10/633,630
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`5.
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`In a double stranded molecule where each strand is 23 nucleotides long, there are
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`223 possible ways of arranging modified and unmodified nucleotides on each strand, and the
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`arrangements on each strand are independent. Accordingly, in such a double stranded molecule
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`there are 223 x 223 = 246 =7.0 x 10" possible arrangements.
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`6.
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`All statements made herein of my knowledge are true and all statements made on
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`information and belief are believed to be true; and further, these statements are made with the
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`knowledge that willful false statements and the like so made are punishable by fine or
`imprisonment, or both, under 18 U.S.C. § 1001 and that such willful false statements may
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`jeopardize the validity of the application or any document or any registration resulting therefrom.
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`Date: 7elp- (cid:9)
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`/2003)
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`16,
`Dr. Jorg Kaufmann
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`2
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`2 of 2
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