V. A. Folen, 1 B.A., M.S. X-Ray Powder Diffraction Data for Some Drugs, Excipients, and Adulterants in Illicit Samples
`
`The development of new compounds with the potential for drug abuse necessitates a
`continuous accumulation of analytical data in the forensic laboratory. Also, the identifi-
`cation of excipients and adulterants in drug samples provides a data base that can be
`used for intelligence purposes. Correlation of cases can provide investigative leads as well
`as being supporting evidence in conspiracy cases.
`The purpose of the present paper is to present X-ray powder diffraction data not
`available in the literature. Included in the paper are data on compounds where more
`complete and accurate tabulations than those already published have been obtained.
`The X-ray diffraction powder method has proven to be very effective and specific in
`the identification of crystalline substances. For example, different hydrates of the same
`compound, as well as polymorphic forms, have completely different X-ray diffraction
`patterns. Compounds in mixtures can be identified without separation. The Special
`Testing and Research Laboratory has been able to identify three components of a
`mixture from a single strip chart recording, which was a composite of the diffraction
`patterns of the substances involved.
`Two modes of operation are utilized in the powder method, one using a camera and
`recording the diffracted X-rays on film, the other involving a diffractometer, detector,
`electronic panel, and chart recorder. The latter method is the superior one in that,
`among other advantages, the resulting pattern is spread out on a chart recording with
`much better resolution of lines. Triplets and doublets on the chart would appear as
`single (broad) lines on a film.
`The Powder Diffraction File, published by the Joint Committee on Powder Diffraction
`Standards, 2 contains inorganic and organic sets of cards containing X-ray diffraction
`data on over 25,000 crystalline substances, accompanied by numerical and alphabetical
`index books. Annually, a new set of data (separated
`into organic and inorganic
`categories) is published. The new sets contain data on compounds not previously entered
`in the file, or replace cards in previous sets with more complete and accurate data. It is
`essential that complete sets of cards be available to the X-ray diffraction laboratory to
`realize the potential of the equipment.
`Much of the data in the Powder Diffraction File, especially older data, has been taken
`from film. Many of the original cards have been deleted and replaced by more accurate
`tabulations. Of those earlier cards which remain, the data are often incomplete,
`especially for organic materials where the lines are confined to lower angles and are in
`Received for publication 1 May 1974; accepted for publication 12 Aug. 1974.
`1Forensic chemist, Division of Drug Chemistry, Food and Drug Administration, Washington,
`D.C. 20204.
`21601 Park Lane, Swarthmore, Pa. 19081.
`
`Copyright © 1975 by ASTM International
`
`www.astm.org
`
`J Forensic Sci, Apr. 1975, Vol. 20, No. 2
`
`
`
`EXHIBIT A
`
`348
`

`

`close proximity. Resolution on film is improved somewhat by using CrKa radiation, but
`still does not approach that obtained with the diffractometer. Therefore, data are
`included in the present paper for compounds already compiled in the Powder Diffraction
`File for which discrepancies have been found.
`
`Experimental Apparatus
`
`A Philips wide-angle diffractometer, equipped with scintillation counter and using
`nickel-filtered copper radiation, was employed. Interplanar spacing d was based on
`(CuKc0 = 1.5405 ~.
`
`Reagent grade chemicals were used whenever possible, crushed to very fine powder,
`and packed in regular sample holders.
`
`The goniometer scan (1 deg 20/rain) was from 2 to 60 deg 20, higher for inorganic
`substances of small unit cell.
`The X-ray tube was maintained at 30 kV and 10 mA. To obtain d-spacings from the
`strip chart recording, a scale [1] previously made from Plexiglas | was used. The scale
`shows the angles along the lower edge (1 in. -- 1 deg 20), and the corresponding
`d-spacings above. The accuracy of the scale is equal to that of the conversion tables [2],
`and use of the scale has the advantage of being much more rapid with less chance of
`error. Relative intensities were calculated, giving the most intense peak for each pattern
`a value of 100.
`
`Table 1 presents the three most intense lines of each pattern, arranged in descending
`order according to the d-spacing of the most intense line. The data are arranged in
`groups corresponding to the Hanawalt search method [3] to facilitate selection of the
`most probable pattern. Relative intensities are tabulated along with the d-spacings. The
`final column in the table gives the number appointed to the compound of interest as it
`appears in Table 2.
`In Table 2 are listed the complete X-ray diffraction data for each compound, arranged
`in alphabetical order and numbered accordingly.
`
`Discussion 1-Ascorbic Acid
`Ascorbic acid is often found in LSD preparations, sometimes with narcotics and
`cocaine. Occasionally, exhibits have been received which were ascorbic acid tablets
`(commercially available), the surfaces of which were treated with solutions of LSD.
`
`Benzocaine is frequently found as an adulterant in combination with cocaine hydro-
`
`
`
`FOLEN ON X-RAY POWDER DIFFRACTION DATA 349
`Sample Preparation
`Operation
`Results
`Benzocaine (Ethylaminobenzoate)
`

`

`TABLE 1--Numerical (Hanawalt) index.
`
`Pattern
`No.
`
`18.4
`18.3
`18.0
`
`17.1
`17.1
`16.9
`16.6
`
`15.8
`15.5
`15.3
`14.6
`
`13.8
`13.7
`12.5
`
`11.5
`
`10.6
`10.4
`10.2
`10.1
`10.1
`10.0
`
`9.99
`9.92
`9.69
`
`4.84
`4.81
`18.5
`
`5.65
`3.48
`4.23
`3.37
`
`4.39
`4.32
`3.98
`7.31
`
`3.48
`4.72
`4.57
`
`4.35
`4.31
`5.53
`
`4.17
`6.10
`3.87
`3.49
`
`5.23
`5.40
`3.89
`7.80
`
`6.96
`3.94
`3.46
`
`5.41
`
`3.35
`
`4.26
`14.1
`3.36
`14.0
`4.34
`5.16
`
`14.1
`12.0
`4.53
`
`8.48
`6.26
`5.07
`5.03
`3.91
`5.02
`
`12.0
`4.04
`3.16
`
`8.72
`
`5.54
`
`3.77
`
`7.98
`7.82
`7.52
`
`7.06
`
`6.90
`6.74
`6.74
`6.50
`
`6.15
`6.13
`
`5.25
`3.69
`3.38
`
`9.24
`5.26
`3.30
`
`4.51
`
`8.82
`
`5.44
`4.24
`3.62
`7.25
`
`8.68
`4.56
`
`4.42
`3.47
`3.36
`4.47
`
`4.08
`7.40
`
`19.9-18.0
`100
`>100
`100
`17.9-16.0
`>100
`100
`100
`>100
`15.9-14.0
`>100
`>100
`100
`>100
`13.9-12.0
`>100
`100
`100
`11.9-11.0
`100
`10.9-10.0
`100
`100
`100
`100
`>100
`100
`9.99-9.50
`>100
`100
`100
`8.99-8.50
`100
`7.99-7.50
`>100
`100
`>100
`7.49-7.00
`100
`6.99-6.50
`100
`100
`>100
`100
`6.49-6.00
`100
`100
`
`31
`100
`86
`
`100
`35
`56
`100
`
`100
`100
`56
`100
`
`100
`60
`30
`
`60
`
`76
`78
`80
`43
`100
`67
`
`100
`58
`96
`
`69
`
`100
`68
`100
`
`97
`
`46
`99
`100
`85
`
`58
`43
`
`18
`57
`51
`
`38
`28
`45
`38
`
`55
`61
`56
`67
`
`100
`59
`20
`
`41
`
`57
`39
`35
`29
`49
`34
`
`84
`42
`94
`
`66
`
`86
`66
`90
`
`72
`
`41
`72
`99
`82
`
`41
`43
`
`9
`12
`59
`
`13
`57
`11
`22
`
`10
`23
`30
`66
`
`72
`44
`68
`
`46
`
`52
`69
`49
`7
`4
`63
`
`53
`19
`25
`
`15
`
`17
`32
`18
`
`38
`
`41
`39
`48
`55
`
`54
`62
`
`
`
`350 JOURNAL OF FORENSIC SCIENCES
`d, 1~ I/Ia
`

`

`TABLE 1--Continued. Pattern d, ~, Ilia
`
`No.
`
`5.88
`5.87
`5.80
`
`5.73
`5.73
`
`5.34
`5.34
`
`5.14
`5.13
`5.07
`
`11.7
`5.39
`10.8
`
`12.6
`4.88
`
`7.80
`6.85
`
`5.11
`9.82
`3.73
`
`4.68
`5.74
`9.44
`
`4.23
`3.81
`
`4.36
`5.77
`
`3.79
`4.79
`6.32
`
`4.85
`
`3.26
`
`3.91
`
`4.78
`4.77
`4.76
`4.75
`
`4.61
`
`4.46
`
`4.37
`4.33
`4.31
`
`4.26
`4.22
`
`4.08
`4.08
`4.07
`4.02
`
`3.91
`
`3.81
`3.80
`
`3.72
`
`3.60
`
`4.24
`4.08
`5.57
`4.53
`
`3.87
`3.68
`3.40
`5.07
`
`4.39
`
`6.82
`
`4.54
`
`4.64
`
`2.92
`6.33
`4.74
`
`4.67
`3.87
`
`23.7
`6.75
`5.43
`3.27
`
`5.37
`
`6.10
`4.74
`
`4.42
`
`4.73
`
`8.70
`4.18
`2.49
`
`8.50
`4.24
`
`3.35
`7.37
`4.16
`3.86
`
`3.14
`
`6.90
`6.06
`
`5.32
`
`4.55
`
`5.99-5.75
`100
`100
`100
`5.74-5.50
`100
`100
`5.49-5.25
`100
`100
`5.24-5.00
`100
`100
`100
`4.89-4.80
`100
`4.79-4.70
`100
`100
`100
`100
`4.69-4.60
`100
`4.49-4.40
`100
`4.39-4.30
`100
`100
`)100
`4.29-4.20
`100
`100
`4.09-4.00
`100
`100
`100
`100
`3.99-3.90
`100
`3.89-3.80
`100
`100
`3.79-3.70
`100
`3.69-3.60
`100
`
`53
`77
`49
`
`60
`96
`
`83
`91
`
`97
`47
`100
`
`58
`
`74
`74
`88
`90
`
`64
`
`50
`
`100
`93
`100
`
`.75
`100
`
`48
`57
`79
`94
`
`68
`
`84
`88
`
`89
`
`84
`
`29
`72
`44
`
`29
`86
`
`77
`87
`
`92
`20
`90
`
`42
`
`43
`53
`54
`67
`
`29
`
`39
`
`45
`80
`44
`
`29
`91
`
`22
`53
`49
`88
`
`23
`
`68
`61
`
`61
`
`71
`
`47
`35
`40
`
`61
`1
`
`29
`33
`
`31
`64
`2
`
`8
`
`5
`70
`45
`50
`
`21
`
`37
`
`71
`27
`24
`
`36
`28
`
`20
`34
`58
`51
`
`6
`
`56
`43
`
`16
`
`73
`
`
`
`FOLEN ON X-RAY POWDER DIFFRACTION DATA 351
`

`

`TABLE 1--Continued.
`
`3.56
`3.54
`3.53
`3.50
`3.50
`
`3.18
`
`3.11
`
`5.27
`4.63
`7.24
`5.45
`3.57
`
`8.52
`
`9.29
`
`4.67
`5.53
`8.24
`3.21
`4.09
`
`4.48
`
`4.67
`
`3.59-3.50
`100
`100
`100
`100
`100
`3.19-3.15
`100
`3.14-3.10
`>100
`
`81
`74
`54
`90
`49
`
`91
`
`78
`66
`51
`62
`41
`
`72
`
`>100
`
`100
`
`Pattern
`No.
`
`26
`65
`3
`67
`60
`
`14
`
`42
`
`d = interplaning spacings of the three most intense lines
`= relative intensities
`
`chloride. Occasional narcotic samples also contained benzoeaine. The X-ray diffraction
`data obtained closely follow those of Owen et al [4].
`
`Caffeine has been found in combination with heroin and amphetamines. It is also
`found in many tablet samples reputed
`to be amphetamine or methamphetamine.
`Crystals of caffeine are very fine needles as seen microscopically. When packed for X-ray
`diffraction analysis the crystals exhibit preferred orientation, producing very intense lines
`at d = 7.42 and 7.52 .~ (a doublet) and d = 3.38 .~, the remaining lines being of
`relatively weak intensity. Therefore, low concentrations of caffeine are indicated when
`lines appear having the d-spacings mentioned above, lines which would .not be seen if
`there was little or no preferred orientation.
`
`Inorganic and organic calcium salts have been found in a large number of exhibits.
`Perhaps the most common are calcium phosphate hydrate (brushite, CaHPO4.2H20),
`calcium magnesium carbonate [dolomite, CaMg (CO3)2], and the two forms of calcium
`carbonate (calcite and aragonite). Calcium sulfate dihydrate (gypsum) and hydroxy-
`apatite [Cas(PO4)3(OH)], have also been encountered. Excellent data for these inorganic
`substances are
`found
`in
`the Powder Diffraction File. Calcium tartrate hydrate
`(C4H4CaOs.4HzO) has been found in heroin samples and calcium lactate hydrate
`(CsH10CaO 6. 5H20) has been used as a filler in LSD tablets.
`
`Cocaine and heroin samples are often adulterated with appreciable amounts of
`procaine hydrochloride. There are some differences between the tabulated data taken
`from film and those in the present paper.
`
`Quinine salts which have been used as adulterants in heroin preparations are quinine
`hydrochloride (C20Hz4NzO 2. HC1.2HzO) and quinine sulfate (C4eH48N404. SO4" 2H20).
`
`
`
`352 JOURNAL OF FORENSIC SCIENCES
`d, ~ 1/11
`1/11
`Cqff'eine
`Calcium Salts
`Procaine Hydrochloride
`Quinine and Quinidine Salts
`

`

`O1
`
`177
`Z
`---I 5
`tD
`
`.-1"1
`"11
`"11
`
`trl
`ID
`o o
`..<
`
`-.n
`x
`z
`o
`z
`m
`i'-
`O
`"11
`
`2
`2
`2
`2
`1
`2
`19
`2
`4
`4
`5
`7
`15
`8
`5
`8
`23
`5
`17
`12
`11
`7
`26
`24
`49
`4
`6
`5
`100
`26
`14
`23
`7
`5
`11
`17
`
`2.175
`2.240
`2.319
`2.440
`2.477
`2.560
`2.664
`2.736
`2.760
`2.898
`2.959
`2.998
`3.08
`3.25
`3.29
`3.35
`3.43
`3.47
`3.56
`3.58
`3.67
`3.73
`3.80
`3,87
`3.91
`4.02
`4.11
`4.20
`4.34
`4.41
`4.48
`4.54
`4.68
`4.88
`5.09
`5.19
`
`11
`17
`20
`13
`4
`23
`15
`42
`18
`24
`7
`261
`3
`
`4
`3
`3
`2
`2
`4
`2
`3
`6
`3
`7
`14
`5
`11
`12
`21
`25
`32
`27
`31
`29
`
`(4) Aminopyrine
`
`5.37
`5.42
`5.55
`5.60
`6.13
`6.63
`6.71
`6.88
`7.07
`7.13
`8.00
`10.1
`11.2
`
`1.896
`1.963
`2.003B
`2.055B
`2.223B
`2.300
`2.370B
`2,445B
`2,550B
`2.685
`2.726
`2.774
`2.920B
`3.055
`3.090
`3.185
`3.270
`1,3.335
`,1"3.355
`[3.42
`~3.45
`
`3.53
`[3.63
`J3.66
`3.73
`3.88
`4.09
`4.51
`4.62
`5.12
`5.26
`5.52
`5.66
`5.76
`6.07
`6.69
`7.24
`7.43
`8.24
`10.7
`11.5
`(3) Aminophylline Dihydrate
`
`100
`11
`11
`8
`24
`8
`7
`3
`7
`13
`4
`7
`6
`43
`4
`54
`23
`Sl
`3
`13
`
`8
`9
`24
`15
`9
`8
`37
`100
`62
`28
`76
`18
`33
`100
`
`2,465
`2.515
`2.816
`3.12
`3.25
`3.32
`3.41
`3.73
`3.88
`4.18
`4.44
`4.76
`4.89
`5.07
`
`(2) 1-Acetyl-2-Phenylhydrazine
`
`62
`90
`34
`
`5.47
`6.32
`9.5
`
`2
`3
`4
`2
`2
`3
`3
`6
`6
`3
`6
`4
`9
`6
`18
`5
`8
`3
`11
`66
`80
`86
`6
`52
`12
`96
`16
`100
`23
`32
`
`1.760B
`1.800B
`1.895B
`1.980B
`2.010
`2.085
`2.135
`2.183
`2.253
`2.290B
`2.340
`2.404
`2.440
`2,484
`2.755
`2.863
`3.08B
`3.22
`3.29
`3.37
`3,67
`3.81
`4.28
`4.36
`4.71
`4.88
`5.65
`5.73
`6.46
`7.37
`
`(1) Acetaminophen
`
`--Complete powder d~ffraction data. (Two numbers bracketed together indicate a doublet," three indicate a triplet; B indicates broad lines). d, ~, I/It d, ~ 1/11 d, ,~ 1/11 d, l~ I/I1
`
`TABLE 2
`
`
`
`

`

`m
`o
`m Z
`o
`o 09
`
`z
`I'n
`-n
`"n
`-,1
`O
`r-
`z
`c ~D
`
`(12) d/-Amphetamine Phosphate
`
`6
`8
`8
`8
`11
`9
`9
`10
`6
`23
`17
`22
`17
`28
`28
`39
`56
`57
`51
`100
`31
`14
`28
`36
`16
`484
`4
`
`2.495
`2.535
`2.580
`2.830
`2.890
`2.959
`3.01
`3.07
`3.14
`3.20
`3.44
`3.53
`3.$8
`3.65
`3.76
`3.89
`4.07
`4.31
`4.57
`4.81
`4.98
`5.08
`6.11
`9.15
`16.5
`18.3
`23.5
`
`6
`6
`6
`6
`9
`
`2.068
`2.131
`2.584
`2.787
`2..827
`
`4.58
`4.77
`4.94
`5.11
`5.23
`5.50
`8.31
`15.8
`(10) d-Amphetamine Sulfate
`
`19
`29
`22
`37
`55
`23
`8
`2075
`
`(9) d-Amphetamine Phosphate
`
`1
`4
`3
`2
`2
`3
`4
`8
`4
`6
`S
`6
`13
`18
`18
`6
`14
`5
`31
`13
`17
`7
`7
`100
`
`1.920
`2.287
`2.541
`2.825
`2.910
`2.993
`3.07
`3.21
`3.25
`3.46
`3.50
`3.66
`3.86
`4.07
`4.35
`4.47
`4.57
`4.72
`4.84
`4.98
`6.11
`9.19
`16.6
`18.4
`
`6
`12
`16
`27
`29
`14
`14
`12
`16
`20
`16
`18
`20
`100
`27
`14.02
`43
`(7) Amobarbital Sodium
`
`3.37
`3.87
`4.44
`4.67
`5.03
`5.32
`5.43
`5.$4
`5.63
`S. 70
`5.78
`6.04
`6.21
`10.06
`
`2
`2
`2
`3
`2
`4
`3
`4
`4
`1
`3
`3
`5
`9
`8
`3
`5
`
`1.531
`1.564
`1.682
`1.745
`1.771
`1.837
`1.960
`I. 2.007
`~2.025
`2.110
`2 142
`2.182
`2.210
`2.233
`2.318
`2.345
`2.376
`
`1
`
`--Continued. co 0
`
`TABLE 2
`
`5
`2
`2
`6
`9
`20
`18
`3
`8
`6
`5
`43
`4
`10
`74
`6
`21
`14
`100
`3
`17
`11
`4
`10
`19
`4
`11
`18
`
`2.967
`3.030
`3.080
`3.165
`3.26
`3.34
`3.45
`3.57
`3.65
`3.67
`3.79
`3.87
`4.07
`4.17
`4.24
`4.38
`4.62
`4.70
`4.78
`5.02
`5.32
`5.43
`5.55
`5.07
`5.94
`6.60
`6.94
`7.71
`
`(S) AmHriptyline HCI
`
`2
`2
`2
`2
`
`2.011
`2.035
`2.061
`2.130
`
`
`
`d, ~, I/I~ d. t~ I/la d. ~ I/I~ d, ~ 1/11
`. O
`(cid:12)9
`11.68
`2,440 6
`

`

`CO
`
`--i
`173
`Z
`
`..q
`3~
`"11
`"11
`
`13 m
`
`o
`
`..<
`
`.x
`Z
`o
`z
`m
`i'-
`O
`
`6
`100
`14
`16
`39
`10
`6
`14
`72
`44
`9
`16
`11
`91
`
`3.030
`3.180
`3.285
`3.33
`3.53
`3.79
`4.18
`4.23
`4.48
`5.10
`5.55
`5.66
`6.32
`8.52
`
`(14) l-Ascorbic Acid
`
`2.070
`2.112
`2.332
`2.725
`2.850
`3.38
`3.57
`3.80
`3.91
`4.17
`4.48
`5.20
`5.65
`8.49
`17.1
`(13) dl-Amphetamine Sulfate
`
`4
`4
`7
`5
`6
`33
`13
`7
`10
`38
`19
`33
`100
`32
`539
`
`4
`
`4
`4
`21
`5
`
`1.840
`
`1.937
`2.229
`2.282
`2.400
`
`2.865
`8
`2.951
`16
`3.17
`20
`3.24
`14
`3.39
`17
`3.50
`19
`3.59
`15
`3,74
`11
`3.87
`45
`4.23
`56
`4.38
`19
`4.55
`9
`4.72
`15
`4.84
`10
`5.10
`17
`5.28
`27
`5.52
`27
`6.33
`6
`7.30
`5
`16.9
`100
`(11) dI-Amphetamine HCI
`
`8
`6
`5
`6
`5
`8
`11
`12
`41
`14
`21
`12
`40
`33
`13
`44
`100
`
`2.270
`2.318
`2.480
`2.610
`2.665
`2.882
`2.949
`3.03
`3.14
`3.39
`3.57
`3.69
`3.88
`3.93
`4.05
`4.23
`4,39
`
`6
`5
`7
`5
`5
`4
`16
`7
`14
`7
`5
`11
`11
`8
`9
`5
`13
`19
`58
`29
`31
`20
`31
`16
`42
`9
`7
`40
`27
`27
`9
`13
`100
`7
`27
`15
`41
`5
`(8) d-Amphetamine HCI
`
`1.948
`1.977
`2.175
`2.210
`2.239
`2.273
`2.390
`2.501
`2.538
`2.571
`2.631
`2.732
`2.761
`2.820
`2.853
`2.920
`3.01
`3.16
`3.26
`3.30
`3.42
`3.54
`3.69
`3.83
`3.91
`3.97
`4.04
`4.18
`4.43
`4.56
`4.65
`4.74
`4.85
`5.37
`5.96
`6.18
`6.53
`15.6
`
`(6) Ammonium Citrate Dibasic
`
`6
`4
`9
`13
`3
`5
`6
`10
`23
`13
`i I
`2
`100
`7
`2
`4
`8
`68
`4
`21
`4
`8
`
`2.463
`2.547
`2.596
`2.665
`2.740B
`2.855B
`2.920B
`3.05B
`3.14
`3.63
`3.70
`3.73
`3.91
`4.06
`4.28
`4.35
`5.05
`5.37
`5.56
`5.68
`7.38
`7.49
`
`<1
`< 1
`2
`1
`3
`2
`2
`2
`2
`6
`5
`4
`4
`6
`4
`
`1.820
`2.040B
`2.088
`2.195
`2.308
`2.350
`2.500
`2.544
`2.622
`2.650
`2.730
`2.755
`2.820
`2.858
`2.890
`
`
`
`1.910 5
`

`

`o~
`o m
`m
`o_
`o~
`
`z ~o
`m
`-n
`
`-11
`o
`r-
`:~ z
`
`O'~
`Oq
`r
`
`1
`2
`2
`4
`3
`3
`2
`4
`7
`4
`6
`11
`2
`3
`7
`4
`6
`2
`24
`10
`23
`22
`20
`4
`22
`20
`18
`64
`100
`17
`5
`9
`5
`
`5.43 4 c
`
`1.840B
`1.890B
`1.935B
`2.028
`2.143
`2.164
`2.352
`2.390
`2.578
`2.636
`2.658
`2.778
`2.882
`2.918
`2.978
`3.140
`3.185
`3.330
`3.380
`3.460
`3.565
`3.60
`3.69
`3.99
`4.06
`4.14
`4.25
`4.39
`4.61
`4.75
`4.86
`5.23
`5.33
`
`(19) Calcium Lactate Penta-
`
`10
`6
`5
`16
`10
`8
`14
`9
`33
`90
`100
`39
`52
`43
`
`2.046
`2.179
`2.356
`2.466
`2.510
`2.753
`3.03
`3.07
`3.15
`3.30
`3.38
`3.42
`3.70
`3.76
`
`9
`11
`11
`25
`11
`20
`12
`20
`42
`21
`12
`11
`9
`25
`21
`100
`58
`
`Hydrate
`
`2.855B
`2.935
`3.08
`3.28
`3.51
`3.59
`3.83
`3.96
`4.04
`4.38
`4.54
`4.74
`5.16B
`5.96
`8.12
`9.92
`12.0
`
`(16) Benzocaine (Ethylamino-
`
`2
`1
`2
`3
`3
`3
`3
`3
`2
`3
`4
`2
`5
`
`1.751B
`1.815B
`1.898
`2.110
`2.180B
`2.302
`2.340BB
`2.400B
`2.478
`2.500
`2.518
`2.552
`2.582
`
`3
`6
`4
`4
`10
`j 1
`56
`10
`100
`28
`34
`38
`89
`28
`61
`60
`22
`16
`
`benzoate)
`
`1.900
`2.280B
`2.410
`2.515
`2.600
`2.952
`3.29
`3.48
`[3.72
`13.82
`/4.13
`~4.22
`4.42
`4.74
`t5.22
`,1"5.32
`7.65
`10.4
`
`2
`1
`1
`4
`3
`1
`1
`4
`4
`2
`
`2
`2
`6
`9
`5
`4
`3
`8
`8
`6
`8
`3
`3
`7
`2
`15
`17
`3
`6
`3
`4
`4
`59
`
`.408B
`
`1.502B 1
`
`1.536B
`1.562
`1.588
`1.615
`.639
`
`1.691 1
`
`1.778
`1.808
`1.855
`1.883
`1.834
`1.980
`2.008
`2.020
`2.056
`2.092
`2.112
`2.140
`2.175
`2.239
`2.260
`2.274
`2.400
`2.442
`2.528
`2.578
`2.635
`2.695
`2.760B
`2.810
`2.870
`2,980
`
`--Continued. 1/1, d, ~, I/la d,~ I/la
`
`TABLE 2
`
`
`
`d,~ I/I~
`1
`o
`

`

`r
`
`Z
`
`--4
`o
`
`"n
`"TI
`
`
`
`O m O
`
`O
`"IJ
`..<
`
`X
`
`Z .
`
`
`
`Z O
`
`ro
`O F-
`"11
`
`11
`7
`3
`4
`23
`9
`3
`6
`6
`7
`28
`6
`6
`8
`6
`5
`4
`22
`11
`100
`38
`5
`3
`3
`4
`8
`36
`5
`12
`15
`4
`45
`8
`30
`5
`300
`
`1.876
`2.090
`2.170
`2.258
`2.412
`2,458
`2.570
`2.620
`2.658
`2.768
`2.813
`2.875
`2.925
`2.975
`3.05
`3.08
`3.20
`3.25
`3.28
`3.37
`3,49
`3.64
`3.75
`4.01
`4.08
`4.17
`4.22
`4.32
`4.76
`4.98
`5.27
`5.63
`6.06
`8.44
`13.4
`16.6
`
`(22) Clorazepate, Dipotassium Salt
`
`(21) Chlorpheniramine Maleate
`
`2
`29
`12
`2
`2
`
`5.77
`6.82
`7.23
`8.80
`9.48
`
`(20) Chlorphenesin Carbamate
`
`2
`1
`4
`2
`1
`3
`4
`3
`5
`2
`5
`7
`22
`100
`4
`12
`6
`9
`48
`
`1.813
`1.930
`2.101
`2.273
`2.315
`2.360
`2.468
`2.600
`2.730
`2.885
`3.04
`3.09
`3.35
`4.08
`4.43
`4.66
`4.78
`5.89
`23,7
`
`6
`7
`10
`15
`9
`14
`7
`10
`6
`5
`6
`
`1.853
`1.884
`2.003
`2.185
`2.270
`2.440
`2.475
`2.575
`2,620
`2,690
`2.750
`
`6
`23
`7
`7
`14
`37
`612
`654
`9
`10
`
`(18) Caffeine
`
`4.27
`4.33
`4.52
`5.63
`6.15
`7.12
`7.42
`7.52
`8.28
`10.67
`
`28
`17
`17
`28
`24
`21
`34
`28
`41
`100
`38
`45
`41
`290
`38
`86
`55
`52
`28
`41
`12.48
`24
`14.11
`34
`15.82
`14
`(17) Butabarbital Sodium
`
`3.16
`3.21
`3.30
`3.94
`4.37
`4.49
`4.77
`4.98
`5.07
`5.25
`5.51
`5.98
`6.12
`7.98
`8.87
`9.24
`9.60
`9.97
`10.83
`
`4
`3
`
`1.748
`1.860
`
`6
`3
`5
`13
`4
`3
`16
`13
`8
`19
`22
`10
`21
`10
`6
`56
`66
`5
`3
`5
`3
`1
`9
`16
`6
`6
`2
`2
`25
`69
`48
`3
`33
`10
`20
`14
`100
`36
`
`2.608
`2.640
`2.662
`2.743
`2.848
`2.885
`3.000
`3.100
`3.205
`3.315
`3.34
`3.43
`3.51
`3.57
`3.60
`3.66
`3.77
`3.84
`3.89
`3.96
`4.08
`4.18
`4.27
`4.32
`4.42
`4.45
`4.87
`5.04
`5.29
`5.54
`5.77
`6.20B
`6.68
`7.04
`7.58
`7.79
`8.72
`15.9
`
`(15) Benactyzine HCI
`
`
`
`I 1.33
`{
`o
`

`

`
`
`z m
`
`m
`
`c z r- 0 "11 m 0 m z
`
`oo
`~
`
`r o
`
`(30) Diphenylhydantoin Sodium
`
`13
`47
`100
`
`9.17
`13.2
`15.3
`
`3
`5
`2
`3
`2
`5
`3
`4
`11
`5
`4
`8
`3
`20
`11
`48
`2
`16
`63
`77
`13
`48
`43
`100
`32
`83
`60
`(29) Diphenylhydantoin
`
`1.997
`2.059
`2.097
`2.177
`2.263
`2.412
`2.538
`2.570
`2.682
`2.834
`2.897
`2.996
`3.05
`3.21
`3.31
`3.41
`3.83
`3.89
`3.97
`4.36
`4.60
`4.88
`5.13
`5.34
`6.85
`7.80
`10.30
`
`2.584
`4
`2.625
`5
`2.735
`10
`2.890B
`6
`2.990B
`8
`3.145B
`13
`3.260
`13
`3.315
`14
`3.41B
`16
`3.55
`29
`3.69
`23
`3.76
`16
`3.84
`16
`3.95
`16
`4.05
`35
`4.18
`80
`4.33
`100
`4.56
`74
`4.72
`54
`4.78
`40
`5.12
`28
`5.22
`40
`5.58
`63
`5.78
`20
`6.14
`53
`6.33
`93
`6.57
`53
`7.02
`26
`7.44B
`36
`8.05
`19
`9.06
`16
`9.58
`33
`(27) Dimethyltryptamine
`
`2.051
`10
`2.144
`8
`2.178
`19
`2.242
`20
`2.410
`8
`2.435
`20
`2.521
`12
`2.547
`9
`2.656
`6
`2.685
`9
`2.717
`5
`2.773
`06
`2.873
`14
`2.891
`15
`3.04
`14
`3.16
`94
`3.22
`18
`3.24
`13
`3.37
`10
`3.51
`21
`3.59
`3
`3.80
`5
`3.90
`35
`4.tl
`10
`4.31
`27
`4.41
`47
`4.53
`96
`4.84
`63
`5.21
`4
`6.11
`16
`6.99
`49
`8.58
`3
`9.69
`100
`(25) Dextrose Monohydrate
`
`3.85
`14
`4.31
`532
`4.50
`18
`4.74
`100
`5.21
`30
`6.06
`39
`7.44
`16
`8.56
`13
`(24) Dextrose, Anhydrous
`
`14
`15
`36
`10
`50
`9
`41
`19
`10
`48
`15
`7
`60
`53
`8
`100
`47
`61
`18
`35
`61
`15
`2864
`(23) Cyclamate Sodium
`
`2.045
`2.315
`2.59
`2.69
`2.795
`2.875
`2.925
`3.02
`3,11
`3.29
`3.45
`3.64
`3.89
`3.91
`4.05
`4.32
`4.47
`4,67
`4.98
`5.18
`5.4
`6.18
`15.5
`
`--Continued. d, 1~ I/It d, ~ 1/11 d, ~ I/I~ d, ~ 1/11
`
`TABLE 2
`
`
`
`

`

`t.O
`GO O'1
`
`--4
`(7
`z
`o .--i
`"n
`"tl
`t~
`i'll --n
`1:7
`o
`-tl
`-<
`217
`,x
`Z
`o
`Z
`t"11
`F-
`O
`"11
`
`11
`5
`11
`11
`11
`11
`92
`21
`14
`9
`17
`23
`11
`97
`100
`59
`61
`46
`7
`60
`4
`
`2.830
`3.02
`3.20
`3.26
`3.53
`3.71
`3.79
`3.86
`3.91
`4.17
`4.53
`4.68
`4.85
`5.11
`5.14
`6.03
`6.21
`7.18
`9.3
`10.2
`11.3
`
`(31) Gtutethimide
`
`6
`17
`15
`12
`15
`11
`56
`56
`15
`50
`16
`17
`19
`3
`19
`
`3.09B
`3.40
`3.53
`3.60
`3.69
`3.85
`3.89
`3.98
`4.38B
`5.83
`6.83
`7.36
`7.70
`8.23
`8.68
`
`5
`20
`7
`
`7
`7
`
`1.635
`1.659
`1.844
`
`1.920
`1.935
`
`6
`11
`6
`9
`17
`14
`5
`24
`23
`11
`17
`28
`8
`4
`9
`29
`7
`62
`20
`71
`6
`100
`100
`91
`41
`29
`54
`14
`59
`10
`(28) 2,4-Dinitrophenol
`
`2.121
`2.179
`2.211
`2.286
`2.321
`2.340
`2.383
`2.536
`2.541
`2.579
`2.620
`2.770
`2.796
`2.850
`2.910
`3.02
`3.11
`3.28
`3.47
`3.54
`3.70
`3.87
`4.22
`4.24
`4.74
`4.80
`5.08
`5.43
`5.79
`11.6
`
`2.213
`2
`2.265
`8
`2.328
`4
`2.652
`4
`2.718
`5
`2.754
`6
`2.898
`9
`2.945
`15
`3.085
`3
`3.185
`6
`3.240
`22
`3.350
`6
`3.415
`36
`3.56
`100
`3.81
`7
`3.90
`15
`4.00
`58
`4.25
`43
`4.37
`47
`4.67
`78
`4.84
`31
`5.27
`81
`5.54
`69
`6.19
`27
`7.18
`19
`7.80
`47
`8.75
`69
`(26) Diethyltryptamine
`
`6
`4
`3
`10
`5
`3
`4
`9
`
`1.723
`1.745
`1.833
`1.857
`1.872
`1.915
`1.937
`2.004
`
`5
`4
`5
`5
`4
`3
`3
`3
`5
`4
`4
`5
`10
`3
`3
`4
`3
`14
`14
`11
`9
`3
`5
`9
`32
`44
`11
`13
`4
`9
`10
`6
`3
`43
`6
`10
`37
`8
`
`1.597
`1.630
`1.668
`1.687
`1.791
`1.827
`1.872
`1.899
`1.918
`1.959
`2.004
`2.030
`2.056
`2.086
`2.132
`2.169
`2.197
`2.221
`2.259
`2.275
`2.299
`2.366
`2.393
`2.423
`2.459
`2.493
`2.558
`2.587
`2.657
`2.862
`2.913
`2.982
`3.03
`3.14
`3.24
`3.33
`3.50
`3.60
`
`
`
`1.951 5
`1.871 6
`

`

`0'~ 0 3 c z o o m z m z m
`
`5
`5
`8
`8
`10
`18
`12
`19
`24
`16
`36
`43
`33
`97
`53
`19
`16
`33
`19
`26
`100
`48
`22
`72
`31
`15
`13
`
`(38) Lidoeaine
`
`2.780
`2.945
`3.02
`3.02
`3.10
`3.15
`3.27
`3.41
`3.56
`3.71
`3.92
`4.07
`4.24
`4.51
`4.73
`5.35
`5.63B
`5.98
`6.27
`6.53
`7.06
`7.21
`7.38
`8.82
`9.06
`9.75
`11.2
`
`.760
`
`1,816 1
`
`1.845
`1.899
`1.928
`1.984
`
`3
`3
`
`
`1 2
`
`4
`6
`2
`6
`2
`1
`3
`2
`3
`4
`3
`3
`2
`6
`2
`5
`3
`6
`4
`
`
`1 2
`
`
`1 5
`
`2
`
`13
`
`
`1 2
`
`8
`4
`3
`2
`
`.743
`
`1.810 1
`
`1.875
`1.897
`1.934
`1.947
`1.958
`2.000
`2.022
`2.061
`2.110
`2.146
`2.168
`2.182
`2.230
`2.260
`2. 282
`2.323
`2.362
`2.402
`2.422
`2.460
`2.475
`2.513
`2.$97
`2.650
`2.705
`2.770
`2.825
`2.890
`2,960
`3.185
`3.245
`3.33
`3.44
`
`eridyl a-(2-Thienyl) Mandelate HCI]
`
`22
`58
`31
`15
`12
`22
`45
`52
`42
`77
`72
`100
`43
`39
`23
`45
`25
`27
`
`3,98
`4.11
`4.17
`4,24
`4.28
`4.34
`4.48
`4.64
`5.14
`5.39
`5.72
`5.87
`6.12
`6.47
`6.95
`7.38
`8.23
`10.5
`
`(35) J8-344 [1-Methyl-3-Pip-
`
`20
`18
`20
`16
`18
`43
`16
`29
`100
`43
`31
`31
`20
`45
`
`2.75
`2.82
`3.02
`3.08
`3.2
`3.37
`3.53
`3.69
`4.08
`4.13
`4.33
`4.5
`4.70
`5.07
`
`(32) 1B-318 (N-Ethyl.3-Pip-
`
`eridyl Benzilate)
`
`7
`3
`
`2.510
`2.700
`
`3
`5
`3
`8
`7
`14
`8
`9
`22
`9
`9
`22
`51
`43
`68
`66
`12
`45
`57
`57
`66
`40
`14
`20
`26
`100
`20
`19
`15
`39
`
`1,845
`1.940B
`1.995B
`2.360B
`2.468
`2.732
`2.782
`2.835B
`2.873
`3.01
`3.08
`3.39
`3.52
`3.59
`3.69
`3.91
`4.08
`4.26
`4.99
`5.13
`5.26
`5.33
`5.74
`6.40
`6.68
`7.82
`8.50
`9.08
`9,40
`
`--Continued. I/la d, 1/11
`
`TABLE 2
`
`
`
`d, ~ I/I1 d,
`11.5
`1/11
`

`

`--4
`
`
`
`5 z o
`
`o ---i
`
`o m -n
`o
`> .<
`~0
`x
`
`z ,
`
`
`
`z o
`
`/-I1
`o i--
`
`(40) Lysergic Acid Diethylamide
`
`5
`10
`31
`12
`22
`23
`72
`47
`19
`69
`52
`99
`18
`16
`23
`58
`100
`25
`31
`
`2,397
`2.485
`2.930
`3.07
`3.28
`3.40
`3.43
`3,47
`3.70
`3.90
`4.01
`4.08
`4.24
`4.58
`4.78
`5.00
`5.51
`6.74
`7.35
`8.30
`
`9
`(39) Lidocaine Sulfate
`
`11.7
`
`2
`2
`
`5
`2
`4
`
`2.235
`2.290
`
`2.418
`2.570
`2.670
`
`Tartrate
`
`61
`100
`
`44
`49
`12
`
`8.43 32 5.80
`
`5.71
`
`9.44
`10.8
`16.9
`
`2
`2
`2
`1
`
`2.050
`2.104
`2.135
`2.162
`
`2.260
`4
`2.285
`4
`2.285
`5
`2.333
`5
`2.354
`8
`2,395
`11
`2.435
`7
`2.479
`5
`2.520
`2
`2.543
`3
`2.569
`6
`2.597
`4
`2.700
`3
`2,744
`I
`2,846
`2
`2.882
`4
`3.08
`2
`3.13
`3
`3.17
`4
`3.25
`5
`3.41
`3
`3.49
`8
`3.53
`3
`3,75
`13
`3.91
`9
`4.20
`28
`4.28
`16
`4.46
`100
`4.54
`50
`4.64
`39
`5.19
`4
`5.41
`19
`7.10
`24
`(37) Lactose Monohydrate
`
`23
`6
`20
`11
`10
`5
`3
`100
`38
`20
`7
`75
`3
`6
`2
`5
`3
`29
`
`16
`7
`5
`9
`7
`14
`9
`11
`52
`9
`12
`29
`13
`31
`47
`67
`13
`15
`13
`
`(36) ~-Lactose
`
`3.50
`3.57
`3.62
`3.72
`3.76
`3.99
`4~ 13
`[4.26
`,~4.3l
`4.47
`4.56
`4.67
`4.98
`5.04
`5.44
`5.70
`6.72
`8.50
`
`2.248
`2.315
`2,358
`2.402
`
`2.568
`2.588
`2.602
`2,708
`2,865
`2,985
`3.08
`3.13
`3.28
`3.31
`3.37
`3.54
`3.61
`3.65
`
`(34) JB-336 (N-Methyl-3-Pip-
`
`14
`33
`35
`57
`53
`37
`47
`
`5.23
`5.4
`6.04
`6.75
`7,37
`8.1
`8.97
`
`eridyl Benzilate HCI)
`
`eridyl a-i2-Thienyb Mandelate HC1]
`
`(33) JB-331 [l-Ethyl-3-Pip-
`
`8
`6
`8
`8
`13
`13
`36
`34
`25
`70
`47
`34
`11
`53
`21
`42
`52
`30
`8
`19
`30
`100
`87
`40
`34
`91
`36
`
`2.478
`2.585
`2.655
`2.880
`2.960
`3.05
`3.09
`3.13
`3.17
`3.44
`3.53
`3.56
`3.83
`3.96
`4.07
`4.14
`4.30
`4.47
`4,74
`4.87
`4.96
`5.34
`5.77
`5.85
`6.66
`6.85
`8.62
`
`
`
`2.420
`2.220 3
`2.375 5
`9.53 56
`5
`o
`

`

`c z i'- 0 "11 0 =0 rrl Z o~ C) o'} 0 Ill z 0 rrl o)
`
`bo
`o~
`
`2.770
`2.825
`2.880
`2.908
`3.14
`3.17
`3.22
`3.32
`3.43
`3.55
`3.69
`3.92
`4.27
`4.41
`4.52
`4.68
`4.83
`4.88
`5.04
`5.13
`5.48
`5.88
`6.53
`6.95
`7.10
`7.70
`9.47
`I 1.7
`(47) Methenamine Mandelate
`
`1
`2
`7
`5
`3
`5
`1
`2
`2"
`1
`6
`6
`17
`16
`23
`29
`16
`19
`22
`20
`2
`100
`1
`5
`2
`25
`11
`53
`
`5
`3
`3
`7
`4
`
`1.975
`2.040
`2.080
`2.214
`2.243
`
`3
`3
`4
`5
`3
`3
`4
`5
`13
`25
`10
`9
`54
`9
`10
`23
`29
`12
`12
`17
`6
`7
`100
`12
`13
`88
`20
`48
`42
`11
`15
`
`2.280
`2.390
`2.510
`2.580
`2.730
`2.865
`2.895
`2.950
`3.055
`3.125
`3.190
`3.260
`3.395
`3.53
`3.57
`3.67
`3.77
`4.00
`4.07
`4.13
`4.44
`4.57
`4.76
`5.10
`5.36
`5.57
`6.12
`6.99
`7.38
`7.78
`8.18
`
`(45) Methaqualone
`
`2
`2
`
`1.742
`1.816
`
`12
`3
`2
`2
`1
`12
`9
`4
`7
`18
`9
`8
`6
`2
`43
`11
`8
`4
`13
`8
`100
`12
`52
`30
`3
`88
`11
`61
`1
`4
`11
`
`5
`5
`
`(43) D-Mannitol
`
`2.054
`2.083
`2.111
`2.162
`2.247
`2.327
`2.493
`2.568
`2.614
`2.670
`2.739
`2.819
`2.854
`2.928
`3.02
`3.15
`3.17
`3.36
`3.44
`3.6(I
`3.80
`4.08
`4.21
`4.34
`4.51
`4.74
`5.20
`6.06
`6.74
`7.73
`8.47
`
`2.013
`2.043
`
`TABLE 2--Continued.
`
`(41) Lysergic Acid Diethyl-
`
`4
`4
`6
`7
`5
`5
`16
`18
`13
`11
`10
`31
`14
`24
`14
`30
`13
`30
`10
`
`2.740B
`2.810B
`2.900
`3.14
`3.21
`3.29
`3.38
`3.60
`3.69
`3.79
`3.87
`4.03
`4.12
`4.39
`4.56
`4.78
`5.04
`5.17
`5.50
`
`10
`18
`20
`10
`12
`12
`41
`3
`15
`22
`46
`100
`21
`
`amide (Iso)
`
`3.62
`3.69
`3.79
`3.97
`4.08
`4.22
`4.42
`4.67
`5.02
`5.25
`5.44
`6.90
`11.0
`
`
`
`d, ~ I/1~ d, ~, I/I, d, ~ I/I~ d, ~ I/I~
`

`

`CO
`
`Z
`5
`---I
`C3
`
`"11
`G9
`
`m
`
`o
`
`-<
`
`x
`o
`z
`ro
`F-
`o
`
`6
`5
`9
`14
`10
`48
`10
`72
`99
`66
`100
`18
`8
`11
`12
`77
`47
`32
`8
`3
`98
`55
`46
`
`2.704
`2.848
`2.882
`2.910
`3.02
`3.17
`3.24
`3.30
`3.36
`3,47
`/3.62
`,,[3.69
`3.78
`"l~ 3.87
`f3.90
`1.4.00
`~4.08
`4.24
`4.47
`4.60
`4.84
`1.4.96
`~5.04
`
`3
`3
`12
`7
`3
`3
`21
`9
`9
`12
`19
`41
`12
`20
`33
`32
`5
`17
`21
`7
`3
`4
`27
`
`2.315
`2.532
`2.652
`2.680
`2.750
`2.783
`2.902
`3.08
`3.12
`3.17
`3.22
`3.35
`3.42
`3.47
`3.53
`3.65
`3.76
`3.87
`4.03
`4.23
`4.29
`4.54
`5.01
`
`(48) Mescaline Sulfate Dihydrate
`
`36
`9
`61
`523
`5
`14
`43
`
`5.72
`6.10
`6.31
`6.74
`7.51
`10.20
`20.53
`
`1
`2
`3
`1
`2
`4
`
`1.918
`1.955
`2.355
`2.410
`2.515
`2.580
`
`41
`29
`13
`2
`31
`11
`3
`100
`(46) Methaqualone HCI
`
`5.78
`6.18
`6.91
`7.38
`8.05
`8.57
`9.18
`11.5
`
`5
`2
`3
`3
`4
`
`1.922
`1.960
`2.015
`2,090
`2.160
`
`1
`1
`2
`3
`3
`
`1.811
`1.890
`l.qO0
`1.925
`1.989
`
`2
`3
`2
`2
`2
`2
`5
`3
`3
`2
`4
`4
`4
`6
`5
`4
`5
`3
`5
`30
`29
`13
`11
`59
`6
`4
`60
`11
`3
`34
`8
`100
`
`(44) Meprobamate
`
`4,03
`4.38
`4.72
`4.92
`5.16
`6.85
`8.05
`13.7
`
`1.931
`2,055
`2.090
`2.193
`2.227
`2.271
`2.343
`2.366
`2,469
`2,509
`2.571
`2,590
`2.682
`2.728
`2.986
`3.05
`3.12
`3.30
`3.36
`3.51
`3.69
`3.72
`3.74
`
`3
`5
`5
`14
`11
`5
`8
`11
`8
`16
`522
`14
`24
`8
`5
`11
`11
`100
`5
`11
`30
`500
`30
`
`2.102
`2.194
`2.317
`2.333
`2.473
`2.523
`2.590
`2.699
`2.801
`2.895
`3,11
`3.27
`3.35
`3.44
`3.60
`4.20
`4.55
`4.67
`5.03
`7.25
`8.37
`9.29
`10.01
`
`(42) Magnesium Silicate
`
`Monohydrate
`
`2
`2
`2
`2
`1
`1
`2
`2
`4
`8
`10
`5
`
`I. 965
`2.095
`2.,305
`
`2.6(10
`2.780
`2.925
`3.04
`3.11
`3.22
`3.28
`3.32
`
`
`
`2.455
`13.08 4 3.94
`5.41 60 5.30 12
`

`

` ffl
`
`z m
`
`~o z t- o m 0 -n m z 60 o 6o m
`
`
`
`o~
`
`24
`27
`27
`33
`18
`39
`39
`58
`55
`27
`21
`30
`82
`36
`52
`61
`18
`27
`24
`27
`39
`27
`100
`52
`36
`55
`85
`21
`70
`42
`27
`36
`11.72
`45
`61
`14.52
`(55) Phenobarbital Sodium
`
`3.003
`3.03
`3.19
`3.25
`3.34
`3.54
`3.72
`3.82
`3.90
`4.12
`4.20
`4.31
`4.47
`4.68
`4.79
`4.90
`5.19
`5.47
`5.58
`5.67
`5.80
`.23
`
`6.65 6.50 6
`
`6.83
`7.08
`7.25
`7.99
`8.12
`0.09
`.75
`
`11.27 9
`
`9.42
`16
`9.54
`12
`(54) Phencyclidine HCI
`10
`3.36
`6
`3.56
`13
`3.86
`36
`4.44
`26
`4.67
`65
`4.98
`48
`5.55
`81
`5.98
`32
`6.35
`32
`6.65
`10
`6.99
`29
`7.85
`10
`8.53
`8.98
`9.99
`280
`11.13
`42
`11.97
`84
`14.11
`100
`(53) Pentobarbital Sodium
`7
`2.374
`6
`2.525
`13
`2.644
`15
`2.81
`32
`2.835
`29
`2.877
`10
`2.92
`9
`3.02
`6
`3.04
`3
`3.13
`4
`3.2
`6
`3.3
`
`(51) Methylene Dioxyamphet-
`
`3
`3
`
`1.975
`2.041
`
`15
`5
`4
`84
`17
`19
`34
`8
`14
`94
`7
`24
`25
`81
`88
`100
`38
`20
`21
`4
`18
`26
`1
`6
`6
`I0
`53
`7
`45
`7
`
`2.825
`2.858
`2.890
`2.927
`3.01
`3.03
`3.08
`3.13
`3.17
`3.27
`3.33
`3.57
`3.74
`3.79
`3.86
`4.02
`4.09
`4.15
`4.19
`4.45
`4.53
`4.60
`4.74
`4.85
`5.03
`5.22
`5.34
`6.55
`12.4
`12.8
`
`amine HCI (MDA)
`
`(49) Methyldimethoxymethyl-
`
`6
`5
`10
`6
`5
`22
`5
`
`2.148
`2.205
`2.235
`2.346
`2.460
`2.518
`2.627
`
`5
`5
`4
`6
`5
`13
`7
`28
`80
`8
`31
`5
`11
`11
`7
`4
`6
`4
`35
`15
`15
`4
`7
`32
`100
`
`2.442
`2.560
`2.587
`2.739
`2.879
`2.915
`3.10
`3.33
`3.36
`3.48
`3.57
`3.69
`3.83
`3.97
`4.28
`4.39
`4.44
`4.77
`5.07
`5.41
`5.68
`5.85
`6.28
`6.77
`10.23
`
`phenylethytamine HCI
`
`--Continued. d, ~, I/Ix d, ~, I/Ia d, ~ I/I~ d, ~ I/I1
`
`TABLE 2
`
`
`
`23
`

`

`o~ o'1
`r
`
`--4
`~
`
`z t
`
`--4
`(3
`-11 --in
`I1
`t~
`.-n
`17/
`
`n -
`
`o
`"-o
`..<
`-.n
`x
`o
`z
`o t--
`-11
`
`z ,
`
`2.635
`4
`2.733
`3
`2.820
`10
`2.875
`10
`2.899
`15
`3.03
`8
`3.07
`17
`3.13
`15
`3.25
`18
`3.30
`28
`3.41
`21
`3.45
`33
`3.53
`22
`3.62
`5
`3.81
`100
`3.92
`15
`4.20
`15
`4.30
`40
`4.73
`10
`4.84
`65
`5.15
`9
`5.35
`8
`5.58
`3
`5.82
`4
`6.10
`84
`6.90
`68
`(56) Phenylephrine HCI
`
`1
`3
`4
`2
`2
`2
`2
`2
`12
`2
`3
`3
`5
`3
`4
`7
`8
`5
`5
`25
`11
`12
`18
`21
`6
`40
`12
`
`1.805
`I. 880
`1.943
`2.008
`2,055
`2.103
`2.135B
`2.180
`2.289
`2,342
`2,470B
`2,640B
`2.698
`2,735
`2.788
`2.863
`2.898
`2.915
`2,960
`3.135
`3.150
`3.185
`3.34
`3.66
`3.75
`3.84
`3.91
`
`2.149 9 4.08 41
`
`6
`9
`6
`9
`9
`18
`15
`18
`21
`24
`
`2.231
`2.263
`2.348
`2.453
`2.554
`2.753
`2.799
`2.890
`2.962
`2.978
`
`38
`30
`6
`31
`7
`29
`100
`8
`4
`58
`14
`
`4.37
`4.52
`4.71
`5.33
`5.81
`6.15
`6.38
`7.00
`8.68
`8.90
`
`3.43
`16
`3.53
`41
`3.75
`45
`3.88
`33
`4.26
`76
`4.32
`38
`4.53
`50
`5.85
`40
`6.13
`36
`6.98
`13
`8.48
`57
`10.6
`100
`(52) Methylphenidate HCI
`
`6
`4
`5
`6
`4
`3
`3
`7
`6
`4
`3
`4
`3
`12
`4
`34
`6
`6
`3
`5
`4
`10
`11
`5
`6
`
`1,707
`1.729
`1.754
`1.779
`1.794
`1.820B
`1.867
`1.888
`1.928
`1.954
`2.014
`2.062
`2.083
`2.160
`2.193
`2.221
`2,333
`2.363
`2.385
`2.420
`2.470
`2,550
`2,590
`2.623
`2.664
`
`(.50) Methylenedioxyamphetamine
`
`3
`4
`2
`2
`6
`3
`7
`5
`4
`
`1,745
`1.820
`i .947
`2.010
`2.150
`2.189B
`2.235
`2.313
`2,400
`
`7
`8
`6
`8
`9
`15
`32
`20
`28
`50
`37
`37
`52
`22
`37
`90
`100
`67
`36
`17
`18
`13
`14
`11
`15
`17
`26
`
`Carbonate
`
`2,210
`2,629
`2,713
`2,780
`2.930
`3.04
`3.25
`3.38
`3.53
`3.65
`3.75
`3.81
`4.08
`4.27
`4.43
`4.53
`4.75
`5.07
`5.21
`5.55
`6.05
`7.02
`8.15
`9.05
`9.42
`11.1
`18.0
`
`
`
`4.30
`

`

`4 t- O
`
`>
`-~ Z
`
`O'~
`O~
`r
`
`3
`6
`
`2
`2
`2
`2
`3
`2
`4
`
`m
`o
`z
`m
`0
`
`co
`z
`m
`o 20
`71
`"n
`
`1
`8
`3
`5
`4
`4
`17
`11
`3
`5
`17
`9
`20
`100
`3
`5
`1
`5
`4
`9
`47
`14
`
`(64) Quinine Sulfate
`
`2.893
`2.961
`3.11
`3.26
`3.31
`3.40
`3.45
`3.54
`3.66
`3.87
`4.00
`4.55
`4.79
`5.13
`5.49
`6.09
`6.31
`6,66
`