`
`MIPO®ECCHOHAJIBHOTO OBPA3OBAHNA
`«BEJIMKOJIYKCKAA FOCYJAPCTBEHHAA AKATEMUA ®V3MIECKOM
`
`KYJIBTYPBI HM CIIOPTA»
`
`Ha mpaBax pyKonHvcu
`
`BEJLAEB AHJIPEM TEHHAJIbEBUY
`
`BJIMAHME MATHUTHOK CTUMYLAMM HA CHJIOBBIE
`
`BO3MOXHOCTH CKEJIETHBIX MBIDNT
`
`03.03.01 ~ bu3nonorns
`
`Jiucceprauna Ha COHCKaHHve yueHou CTeNeHHn
`
`KaHannatTa OnvonorMyeckux HayK
`
`HayunepyKoBoyUuTesb
`
`WokTop Guomoru4eckux HayK,
`
`mpodeccop Popognuuyes P.M.
`
`Allergan, EX1083
`
`

`

`
`
`
`TJIABA 1. OBZOP JIATEPATYPDI.....sssssssesesssnseesessnesenseesssceesnsesnensnsnenrerenssensazentey 9
`1.1, OGuad xapakKTePHCTHKA MBILICHHOH CHUIBI.....sssseersserereessereessesererecereeseesenees9
`1.2. MeToubl pa3BHTHA MBILICHHOH CHIIBE .....secesseeeererereeressueeesucesssuesensuessseseesnasees 18
`1.3. MarnuTHad CTHMYNALA B MCCHCTOBAHMAX UCTIOBEKA....s.cssecsssereerenrercerertees27
`DJIABA 2. OPrAHH3ALMA MW METOJIbI VICCIIETOBAHS....seeeesesesesseeeeeee35
`2.1. KoHTHHreHT A opraHvsallan HICCHETOBAHWA oo...ssessceseesenesesenssesessenersenensuseeerss35
`2.2, METONBI UCCHEMOBAHUA .....sscsesserserseeessesseenecenseneatsnnscencnnsanencansnsncnnensegeeetets36
`2.3. YcnoBuad perHcTpalan geKTpOMHOrpapHyeckHx NapaMeTpoB BO BpeMA
`HPOBCCHHA SKCIIEPHMCHTA...sssssscssenennssvessenseessnsasscnsncnnsnesenenstanaseeeeeeeee40
`2.4. MeToubl MATEMATHUCCKONM CTATUCTHKM....sscsesseessreerssserssescesersnssencenennerssetees42
`TJIABA3. OCOBEHHOCTU BbI3BAHHbIX MbILEGHBIX OTBETOB TPH
`MATHUTHOH H OJIEKTPHSECKOM CTUMYJLILMM
`TIEPH®EPHUECKOLO HEPBA ...sssesscsseneseereenennenrensensanenenenasenenenscnnaneesesstesteren243
`3.1. HsmMenenusa NapaMeTpos BEISBAHHBIX MBIMC4HBIX OTBETOB TipyBenuueHu
`CHIIKI OHOKpaTHOH MarHHTHOH H QIeKTPHYecKkoH CTHMYIAQMA N. tibialis ........44
`3.2, Vsmenenva BeIMUMHEI BpailaTeIbHOrO MOMCHTA IPH NOBLILCHHM AaCTOThl
`i HHTCHCUBHOCTH PHTMHYCCKHX CTHMYJIALMOHHBIX BOSICHCTBHI...,..csseeeeneeees50
`3.3. Brusnue MarHuTHoil CTHMyJIANHH Ha MMITYJIBCHY!O AKTHBHOCTh OTCIBHBIX
`JIBHTATeNbHBIX eAMHHI M. QASITOCTEMUUS....ssesccssersseensnesensecssnnensnesenensecnsanennssensy58
`TJIABA4. BJIMAHME MATHATHOCTUMYJLALIMOHHOM TPEHMPOBKH
`HA CHIOBLIE BOSMOXKHOCTU CKEJIETHBIX MBILUDT ....eeleeeeseesereererenes63
`4.1, Vsmenenve noxa3zatenel MbIMetHOCHIbI IPH MarHHTHOH CTHMYIAIHH
`MODULI vessescsuessecssscsssessnesuecsvssscsenesanecnseonesssonnsnenenasanscensnnsnssngnseesngegneseese eee sete ee
`4.2. TIwnamuka MBILeYHOH CHIBI Mocie TipexpallleHua
`MAYHUTHOCTHMYIALMOHHOH TPEHMPOBKH «..-ersecssssesssseensensentcennennenseenestsetse72
`TILABA 5. OBCYIKJTEHVIE PESYJIBTATOB...ssssssssssssssensenseneenrsrsntensentnnenenesensens80
`BBIBOJIBI0.0...ceeeeeeeeeereeeceauenguesnecanecsuessensusesneesesQeeesteenessesQenOeCAAeHOseeeeteeggeet22000089
`TIPAKTHUECKHE PEKOMEHTIALIM oo.sseecsteeserssersserssentenneesennnennenneensssterre91
`CTIVMICOK JIUTEPATYPBI....csserceccsereretess ceuuacecenaussenscsesesneuaueseeceetasanensnenensensssewsess92
`
`Allergan, EX1083
`
`

`

`ATO — aneno3uutTpubocbopyar KucnoTa
`BMO — BEI3BaHHBI MOTOPHBIM OTBET
`
`JIE — npuratenbHas equnuila
`MBM — MakcuMasbHEI BpallaTevIbHbI MOMEHT
`
`MII ~ moToHelipoHHBIi ys
`MIIC — MakcHMaJIbHad MpOH3BOJIbHad CHa
`
`MC — MarHuTHad CTHMYJIANAA
`
`PHK — puGonyknenHopad KucmoTA
`CTY — comaToTponHpilt ropMoH
`
`T — TecuIbl
`
`LHC — nentpambuad HepBHaa CHCTeMa
`MI — sneKTpomHorpamMMa
`
`JMC — siiekTpOMMOCTHMyJIALIMA
`
`3C — sneKTpH4ecKad CTHMYIALHA
`
`GM — nkpoHoxKHad MBIA
`
`SOL — kamMOasloBHaHad MBIA
`TA — nepennaa SonputeSepiiopad MBIA
`
`
`
`Allergan, EX1083
`
`

`

`
`
`BO3MO%KXHOCTH
`CCJIeqOBaHHS. Cynopbie
`AKTYyaJsIbHOCTh
`
`MO3BOUMOT OKa3bIBaTh eweHalpaBienHoe BIMAHMe Ha OKPy2Karolly!o cpeny H
`o6echeqHBaTh ajaliTaljvio opraHH3Ma deloBeKa K pa3JIM4HBIM YCHOBHAM eTO
`
`KMSHELeCATeENBHOCTH Ha
`BCeX 93TarIaX HOcTHaTaIbBHOrO ouToreHe3a
`
`Bopo6ses, 1989; M.L. Foss, S.J. Keteyian, 2008; A.B. Camconosa, 2011; A.A.
`
`Uennoxos, 2014). Oco6o BaxHoe 3HayeHHe CHHOBLIG BO3SMO2KHOCTH HMMEIOT B
`
`.
`crlopTHBHOH JICATEJIBHOCTH, TaK Kak pe3syIbTaTEl B paze BAAOB cHopta BO MHOTOM
`
`onpeemmMoTcA CHJIOBbIMH crlocoOHocTaMH crioptcmeHos
`(B.M. 3alMopcKHi,
`
`
`2009; A.V. Herpe6ax ap., 2011).
`K HacTosIeMy BPeMeHH HaKOMJIeH OSUIMpHEMT 9okciepHMeHTaIbHBI
`
`MatepHan 06 sdexTHBHOCTH pa3s/IHYHBIX MeTOAOB WM TOZXOLOB K pa3BUTHIO
`
`CHNOBEIX cllocoOHocTeii 4estonexa (B.C.Ilenxmax & Op., 2006; M.H.Stone etal.,
`
`2007; B.E. Uypcuxos, 2011; O.JI. Bunorpazosa H Ap., 2014). Umerotcs cBeqeHHa
`
`0 bu3sMonorMdeckHx MeXaH3Max, Jic7KallHx B OCHOBE pa3BHTHA CHJIBI CKEJICTHBIX
`
`— enn (R.M. Enoka, 1988; 10.B. Kopsraua, 2003; P.M. Popoaunses, 2005; J.
`
`_ Gondinetal., 2014).
`
`
`
`Llensti clierjMasIMcTOB=TIOCBAILeHpay yccnenoBaHHit
`
`
`OBHIX BO3MOxKHOCTeM yenoBeka (HI.
`
`HeTpayMUMOHHBIX MeTOOB MOBBIMCHHA cH
`1979; B.. Degotosa, 2010; G. Attene et al., 2014), cpequ KOTOpBIX
`
`Patos,
`Jbl K pa3BUTHIO CHIBI
`
`HanOonee BCECTOPOHHe ONHCaHbl MeTomMuecKHe TNOTXO
`EKTPOCTHMYIIALMM B COCTOAHHM TOKOA HU
`
`KENCTHEIX MBIND HOcpeACTBOM UX ol
`HHeETOCpeACTBeHHOM BbINOIHCHHH MBILMeYHOH paborTel (GM. Kou,
`
`IeCHAKOB, 1977; A.A. Huxonaes, 1999; J. Gondin etal., 2005).
`
`‘SueKTPOCTHMYTANHOBESS TpeHupoBKa MBbIMMedHOH CHIBI WMeeT HEKOTOPBIC
`
`MUCHHA, CBASAHHBIC C MOABIICHHEM GoneBbix oUlynjeHu u WucKomdopta,
`AKOHOMEPHO BBISBIBACMEIX BOSCHCTBHEM gieKTpHuecKoro pa3fApaxkeHHs. Taxue
`
`
`
`Allergan, EX1083
`
`

`

`
`KOTOpad TiO MeXaHH3My BO3OyKHeCHHA MBIUeC4HEIX KH HEPBHBIX KIIETOK aHajvornydHa
`onekTpwyeckolt cruMyNauun. B cBasH ¢ STHM 6bNpoBeeHb! MCcIesOBAaHUA 10
`
`W3YSCHHIO BIMAHHA CHCTeMAaTH4eCKOH MarHVTHO CTHMYNALUMM CKeJIETHBIX MBIT
`
`
`B COCTOAHHH OKOHa MpOABJICHHEe CHOBBIX CHOCOOHOCTEeH Y 3OPOBBIX MOOABIX
`moyen (P.M. TopogHuues uM Op., 2007), KoTOpble moKa3sallu stdekTHBHOCTB
`
`MarHHTHOCTHMYJIALIMOHHOM TpeHHpOBKH Ha CHTy CKesICTHBIX mar. [ipa takor
`
`TpeHupopKe HeoOXofMMO BO3feHCTBOBaTb Ha MbIIIINY OUeHb MOLDIHEIMH
`
`CTHMYJIaMH, HO TeXHHYeCKMe
`BO3MOXKHOCTH HarKe HOBeMMIMX MarHMTHbIX
`
`
`
`CTMMYyIATOpOB cHOcOOHI+eHepHpOBaTb TOJIBKO onpemeneHHoe
`
`
`WHTCHCHBHEIX CTuMysIoB. C yaeTOM 3TOrO OOcTOATeNCTBA WM aHaW3a cBeqeHHH
`
`IMTepaTypH NWpeACTaBIATOch ONpaBAaHHBIM M3SY4HTb BO3MOXKHOCTH M3MeHCHHA
`
`CHIIOBBIX clocoOHocTer MBIHocpencTBoM Gomee cna6oro 10 UHTeHCHBHOCTH
`
`
`MarHuTHoro BO3eHCTBHA Ha MbILMUbI-arOHHCThl UBYWOKCHMA B mpowecce ero
`
`_ HeTOcpeCTBCHHOTO BBINOHEHHA.
`OGpexr uccseqoBanAA — MeXaHH3MbI BUIMAHHA MarHMTHOM CTHMYJIALHH
`
`
`ST Ha UX PYHKUMOHAIBHBIC CBOHCTBA.
`IIpeqmMetT vnccleqoBaHHa — THHaMHka CHJIOBbIX BO3MOXKHOCTeH MBIT TIpu
`
`
`_posmelictBHH MarHATHOH CTHMYJAIMH.
`[unoresa — npestiomaranoch, 4TO pUTMMYecKad MarHUTHad CTHMYyNALA
`
`MBI, BHIZLIBAIOWUAA AKTHBALMIO ONONHATCNBHBIX HBUTaTeNbHBIXCHMHAN, 6yneT
`
`[OCOOCTBOBATb PasBUTHIO MBIMeTHO CHIE.
`
`Ilene paSoTE 3akyouaach B W3yseHHH BO3MOMKHOCTeH MOBbINICHHA
`
`pumeHoli CHJIBI TOCpe]ICTBOM puTMueckori MarHHTHOW CTMMYAlHH MEIN Ha
`
`
`VXIIPpOH3BOJIBHOTO coKpalieHHA.
`3anaun accresoBaHHsa:
`MBIMICYHBIX
`BriBaTE ocoGeHHoctH pedmeKTOpHEIX
`fbIX waHocuMol Ha MlepudepwueckHH HepB ofHOKpaTHOH MarHuTHOH
`apasmwanoit MHTCHCMBHOCTH.
`
`
`
`
`
`
`
`
`Allergan, EX1083
`
`

`

`pasnmuarolietica 0 wacTOTe HM HHTCHCHBHOCTH CTHMYJIOB, Ha CHJIOBbIE MBIMICTHBIC
`
`
`cioco6HocTH.
`ocoGeHHocTH W3MeHeHH «MBIMeuHOH
`3. Onpenenuth
`
`Bo3eHCTBHH MarHHTHOH Hi gneKTpHueckoH CTHMYNAUMH C IebiO paspaOoTkH
`
`ONTHMaIBHOTO pexKHMa MarHUTHOCTUMYJIALMOHHOH TpeHHpoBKu WIA pa3sBATHA
`
`
`CHIOBIX: CHhocoOHOCTel MbILIL TOIeHH.
`CHJIOBBIX croco6Hoctreli welopeka mo
`4. Wiccneqosath H3MeHeHHe
`
`BIIMAHMeM Kypca pHTMM4eCKol MArHUTHOM CTHMYJLALMM, HAHOCHMOH Ha MBILIIIbI
`
`
`HeIOCpeACTBCHHO B xone HX COKpalieHhaA.
`Hayauas Hopnsna. B paGoTe Mouy4eHbI HOBBIC cBelzeHia 06 W3MeHeHHH
`
`petbextopHol BosbysHMocTH MoTOHeMpoHoB CMHHOTO Mosra TIpH yBeIMdeHuM
`
`KpaTHol MarHuTHOH CTUMYJIAIHH rlepHdepuyeckoro HepsBa.
`
`WMHTCHCHBHOCTH OHO
`HBI€ OTBETHI, BbISbIBACMBIC
`Tloxa3aHo, UTO MaKCHMasIbHBIe pedeKTopHbIe MbiLied
`
`BbICOKOHHTCHCHBHbIM MarHHTHBIM BosnelicTBHeM, MOCTHTAatoTcr TrpH MeHBITCM
`
`B corydas KCTIONbSOBaHuA gekTpHueckoli CTUMYJann
`
`TIpeBbilieHuu Mopora, 4eM
`yBeIM4eHhe
`nepudepw4eckoro . Hepa.
`BuiapileHo MeHBIIee
`
`ppallaTesbHoro MOMeHTa
`IPH TOBLIMIEHHH UacTOTbl
`Ww WHTCHCHBHOCTH
`
`yelicTBHMa Ha MBILIMbI, 4eM pH auleKTpH¥ecKOM
`ATMH4CCKOTO MarHHTHOTO BO3
`
`JMCKOMQ@OPTHBIX
`oB TO 2%e BpeMA OTCYTCTBHe
`6omeBbIxX H
`wu
`
`pasapaxkeHHu
`mys108. BriepBbie YoTAHOBIEHO,
`
`OMlyilenui B YCHOBHAX HaHeCeCHHA MATHHTHEIX CTH
`TO. TATHAalaTuHeBHBIM Kypce MarHuTHOM CTHMYJIATUMA CKeNeTHBIX MBIA,
`
`yInlecTBILIeMol Ha
`qwaer CHOBE
`(hove HX MpoH3BONbHOTO COKpallicHH®, MOBI
`
`cTe MakcHMaIbHoro CHJIOBOTO
`‘OCOGHOCTH MBI, OTpaxarolmmMeca B TpHpo
`
`ppalljaTeyIsHoro MOMeHTa Hi yBeNHueHHH MOLTHOCTH HMcxomaero WpaiBa Ha
`
`elipOHbI
`CMMHHOrO MO3Ta. OnpezeneHbl
`+3aKOHOMepHBIC W3MeHeHHA
`
`eTpoB 9uleKTpH4eCcKOvi AKTHBHOCTH MBIOII, jlexKale B OCHOBE TIOBBIMNICHHA
`WIbI HXCOKpalleHua B pesyETATe MarHHTHOCTHMYJALMOHHOK TPeHHpOBKH.
`
`opeTHueckan 3HadHMOCTE. Tomyyenunie B padoTe JaHHBIe pactiMpsroT
`
`mHpIe MpeycTaBieHHa o MexaHH3Max BHMAHUA BbICOKOMBTCHCHBHOTO
`
`
`
`Allergan, EX1083
`
`

`

`
`MBIT WMeloT 3HaveHHe MIA pa3BHTHA TeOpeTH4eCKUXx TipecTaBieHuH oO
`
`dakTopax, oOlmpemeMomux adbeKTHBHOCTS Pa3IM4HBIX TO pHpoye BHeINHHX
`
`CTHMYIALMOHHBIX BOSTeHCTBUM Ha HePBHO-MBIMIC4HBIN alilapaTt YeOBeKa.
`
`Iipaxrnudeckad 3HadHMocrTh. PaspaSoTaHHEli MeTORM4eCKHH TOTXOR
`
`TIOBLINIEHHA MBINeGHOH
` CHIbI
`NOCpeACTBOM MarHATHOCTHMYJIALHOHHOK
`
`
`TPCHHPOBKH MBI ONOHAeT CHeKTp HeTpanyMUMOHHBIX MeTODHK [JIA pasBuTHa
`NBUPATeNBHEIX CocoOHOCTeH YeTOBeKa. MarHuTHad CTHMYJIALMA MBIMOKET
`
`6BITh CHONb30BaHa
`B KMHWYeCKOM TpakKTHKe MpH peaOuIMTaljHOHHOM
`
`BOCCTAHOBICHHA JBMraTebHEIX QyHKUMK MallMeHTOB focile ‘ TOBpexTeHHA U
`
`3a60NeBaHHH CNMHHOTO MO3Tra H CKeJICTHBIX MBILIL. TlomyyeHuple aHHble o6
`
`W3MeHeHHH peNeKTOPHEIX MBIWICHHEIX OTBCTOB H CHIOBOTO ppalilaTeuIbHOrO
`
`MOMeHTa TIpH yBeNIH4eHHH CHJIbI M YacTOThl MarHuTHoit
`Wo oNeKTpHyecKkow
`
`_cTUMyAIM mepudbepw4eckoro HepBa H CaMHX MBIIIIT MOXKHO IIpHMeHATS Np
`
`‘MOJeMpOBaHHA HallpaBleHHOro
`BO3HeHCTBHA
`CHIIOBBIX
`TpeHHPOBOUHBIX
`
`TIpOrpaMM Ha (yHKUMOHANHOe COCTOAHHE MBIITedHOLO alilapata CIlIOPTCMeHOB.
`
`:
`Ocnosupie nosoxKeHHA, BLIHOCHMBIC Ha 3allaTy:
`
`1.
` TlocraxrupayvonHEri odexT, BbISbIBAeMBI TATHANWaTHAHeBHOW
`
`Me THMTHOCTHMYIALMOHHOM TpeHHpoBKoOw, coxpaHAeTcA TO TpuHaMaTH CYTOK,
`TOOTPAKaeTCA B MOBLILICHHOM YPOBHE Kak MBIMeYHOH CHIbI, TAK M WapaMeTpoB
`
`KTPHUeCKOMt
`aKTMBHOCTH MBIIL-arOHHCTOB
`B mpouecce
`
`KCHMANbHOTO yCunHa.
`
`lod
`CHIBI
`MBILeuHOn
`Yaenmmuenne
`
`(THOCTHMYNALHOHHOM TpeHHPOBKH MBIIII conmpoBoxmaerca H3MeHeCHHeM
`
`TOpHOH
`Bo3s0yMHMOCTH MOTOHeMpOHHBIX
`TlyOB,
`obecneaMBaronyux
`
`menwe yBuraTesbHOrO WelicTBuA.
`.
`
`MaxkcuManbuad aMIUIMTyqa pedieKTOpHBIX MBILMIedHbIX OTBCTOB,
`
`BIX BLICOKOMHTCHCHBHOM MarBuTHO CTHMYJIAIMeH M SeKTPHdecKHM
`ueM mepHiepHueckoro Hepsa, OCTOBepHO He pa3yindaeTcx, ATO
`
`
`Allergan, EX1083
`
`

`

`BOJIOKOH pH o6onx
`
`9sepeHTHBIX HCPBHBIX
`adbepeHTHEIX Hu
`
`CTHMYNALMOHHOTO BO3eKCTBHA.
`
`Anpo6auna pa6ornt.
`Ilo MaTepvalaM uccepTallMH omyOmuKoBaHo 9
`
`TWevaTHbIXx pa6or, B TOM 4HCIIe 2 cTaTbH .B XYpHaslax, BXOWAINUX B MepedeHb
`
`BeyIWHx pelleH3sHpyeMBIx Haya4Hbix 2KYPHANOB U vw3yaHun, PpeKOMCHOBaHHBIX
`
`BAK Muuuctepcrsa o6pa30BaHHa HW HayKu Poccniicxoli Penepauuu. PesybTaTb!
`
`YccHenoBaHHa OWOKeHEI
`HW oOcy2KTeHbI Ha: VIL u VIII Bcepoceniicxo c
`
`-KoHepeHuH MO U3HONOrMM MBI HM
`
`M@KAyHAapOAHbIM yuacTHeM ILIkone
`K H3YUeHHIO KIlaCCHHeCKHXxX
` -MBLIeaHOH =jeaxTebHOCTH «HoBble MOAXObI
`
`mpo6siem (Mocxsa,
`2013,
`2015); Bcepocculicxoli Hay4Ho-lpakTHyeckou
`_kondepeHunu @AHHOBaMOHHEIe
`~4TeXHOJOTHH
`NOBBINICHHA
`
`
`2013); XXII cbesye musnororMecKoro
`paGorocniocobHocTH» (Benuxue Jlyxu,
`V PocculicxoHw c
`oOmlectBa
`iM. WIL Tasnosa
`(Bonrorpas,
`2013);
`
`KITyHAapONHEIM
`yaacTHeM KoHdepeHuMy
`«Yupapnenue
`
`
`ozaBoricK, 2014).
`
`PesyJIbTaTEl viccnewoBaHHA WH MeTOMMKa oneHK
`HEI NpHMCHALOTCA B CII0pTHBHO-
`a cHTHOH cTHMyauveH MBI BHEApe
`
`e «Crpener» OOO «la3mpom TpaHcras CaHktT-
`
`)POBHTEILHOM KOMIUIEKC
`JOIYMY,
`MyHHUMMasibHOM
`pro
`—
` IlcKoscKoe
`
`anua pete «JleTCKo-
`OBATEIBHOM yupexKeHHe MOnouHUTeNBHOTO 06pa30B
`7pykrypa Hu oGbem AHccepranun. JluccepTalHi, o6nemom 115 cTpaHHt
`
`OUT M3 BBefeHHa
`HM
`5
`IAB, pKMOUaIOIMX ob30p
`
`tTeKcta,
`cocT
`w3noxeHHe
`
`onucaHHe MeTOOB nccyleqOBaHHA,
`o6cyxKqeHHe,
`'TOB
`coOcrBeHHEIx
`viccneqoBaHHi
`mw
`HX
`
`pexomenyanuit, cnucka JIMTepaTypbI M AByX akTOB BHeEApCHHA.
`
`«ut 13 pucyHKoB u 12 TabmMIL. Buonuorpabua Bkmouaet 196
`
`ycrounuKos (107 oredecTBeHHBIX, 89 WHOCTpaHHBIX).
`
`U CHOBLIX BO3MO%KHOCTeH
`
`
`
`Allergan, EX1083
`
`

`

`
`
`
`
`
`1.1. OGmas xapakrepucTHka MBIMIe4UHOH CHIBI
`
`
`CyuloBbie BO3MOKHOCTH 4eNOBeKa MMeIOT CYIIeCTBeCHHOe 3HateHHe B ero
`
`MOBCeMHeBHOH M TpyNoBOH yeaTenbHocTH. OcoOo BaxKeH YpOBeHb pa3BHTHA
`
`_ CHIIOBEIX BO3MOXKHOCTeH JI MOCTWKCHHA BbICOKMX Pe3YJIbTaTOB BO MHOTHX
`
` -BusaX cropta (10.B. BepxollaHckui, 1993; B.H. Tnatonos, 2004; A.A.
`_ Bacunenxo, 2006). Mog cunov monuMaetTca cCMoco6HocTs YeoBeka NpeosoueBatb
`
`BHEIIHee COMpOTHBIeHHe WIH MpOTHBOJeHcTBOBaTh €My
`3a CHT AKTHBHOCTH
`meuo (B.M. 3atuopcxKui, 2009). B cu3vonormu paziwu4aroT abcomOTHy!0 ¥
`
`THOCHTEMBHY10 mpnuiteuny1o cuny (P.V. Komi, 1986; C.10. Bepummuxni, 2005).
`
`COIOTHOM CuO Ha3bIBaloT OTHOWeHHe MaKCHMa@JIbHOM MBIMeYHOH CHIBI K
`
`»HBHONOTH4eCKOMY MOMepeyHuKy MBILIBI (TIOManM NomepedHoro paspesa BCex
`MBINICUHEIX BONOKOH). MsMepseTcs 0a B HBIOTOHAX WIM KWJIorpaMMax CHIIbI Ha 1
`
`(H/cm? unu xr/cm?), OTHomenne MaKCHMaNbHOH MBIWIedHOH CHIBI K ec
`
`MUeCKOMY nlonepewHuky — TOJMMMHe B ICOM, olpeyesisemMow YHCIOM H
`
`HHO OTNCNbHBIX MBIMICYHEIX BOJIOKOH, Ha3bIBaeTCA OTHOCHTEJIBHOH CuOn.
`
`w3MepseTca B Tex 2Ke equHuIax. IIpH cpaBHeHHM CHIOBBIX BO3MOKHOCTeH
`
`
`
`
`
`TunNaXx
`
`W30METPHUeCKOM,
`cokpalljeHHi:
`MBIMICUHBIX
`TECKOM, SKCICHTPH4YCCKOM H W30KMHCTHYCCKOM (H.IL Anncumosa,
`papas, 1985; T.JI. Hemuposcxas, 2003; H.M. Tap6eesa, 2013).
`-— 9TO coKpalleHHue MBIMIIbI,
`IpH KOTOPOM OHa pa3sBuBaeT
`
`
`Allergan, EX1083
`
`

`

`
`MeHbIle HallpmKeHHA MBIMMIbI. OKCLEHTPHIeCKOe coxpamlenue IIpOHCXOAUT B TOM
`
`cnyuae, ech BHeIIHAa Harpy3Ka Sombie pa3BuBaeMoro MBIMINeH ycuHa, a cama
`
`Mpa yoymusetcs. [IpH TakoM Tue MBIMedHOrO COKpallleHHa pasBHBactcs
`
`wavbonee 3HaYHTeNbHai CHa B CpaBHeHHH C ApyrMMH THIaMH MbIIedHOrO
`
`coxpamenus. U30KuHeTH4eckocKoe — 3TO CoKpallleHne MBITo6ecriewBatolliee
`
`W3MeHeHMe
`cycTaBHOrO yriia © MOCTOAHHOM CKOpOCTbIO NPH KOMMeHCaluu
`
`MeHsIOIero HalpmKeHd MEIN,
`MWocpeqCTBOM
`peryiAlMH
`
`
`. CONPOTHBIICHHA. CoxpalienHe TaKoro THA WOCTHraeTcCA TOKO Np NoMomyH
`CHeNMaNbHBIX MMHaMOMeTPHYeCcKUXx yetpoiicts. Jina oGecnexeHua MOCTOAHHOH
`
`CKOpOCTH NiepeMeleHHA BHCINHAT Harpy3kKa BOSpacTaeT B TEX CYCTA@BHBIX yrJlax,
`
`Tae MBIA MOKeT pa3BUBaTb 3HAYHTeIBHOS HalpwKeHHe H, Hao6opoT, Harpy3ka
`
`yMeHBUIaeTCA IIpH TeX yrWax, B KOTOPBIX, MBIIIa pasBUBaeT MeHbIIee ycuse
`
`. Ckypsugac, 1988; P.M. PopoaHnues, 2005; C.A. Moucees, 2010).
`
`“Onpenenenve MEIMeuHO CHIBI y YeNOBeKAa OCYINeCTBIAeTCA B lipowecce
`
`POH3BOJIBHOTO yYCcunHngA, CTPeMJICHHA MaKCUMasIbHO COKpaTHTb niecelyCMbie
`
`ar pi (FO... Tpummua, 2012). B atom cmyuae pa3BHBaeTCH MaKCHMalIbHas
`
`HSBONIbHaA CHa (MIIC). IIpu paccMoTpeHHu CHJIOBbIX BO3MOXKHOCTeH Kak
`raTeNbHOTO KauecTBa YeOBeKa TIPVHATO BbIeMATE CNeMYIOWHe BHP! CHIBI.
`
`HHO-CHJIOBLIC CHOCO6HOCTH H CKOPOCTHO-CHJIOBBIC cmoco6HocTH (B.M
`
`cK,
`1970). CoOcTBeHHO-cHIOBbIe CHOCOOHOCTH TIposBIMIOTCA MpH
`
`1eCKHXYCHNMAX H MeIIeHHEIX JeyKeHuax (B.H. [fratoxos, 2004). Ilona
`
`CTHO-CHIOBBIMH CIOCOOHOCTAMH TNIOHMMacTCa YMeHHe yeyloBeKa pa3BHTb
`
`
`e ycuIMe B KpaTualilMi TIpoMexkyTOK ppemeHu (JJ.B. [lonon u Ap.,
`MOryT 6bITh NOCTHTHYTSI 34 CdeT YBEMMYCHMA CHJIbI HIM CKOPOCTH
`
`IMeHUA MILI, wu o60“X KOMMOHeHTOB. OOprMHO Hav6onbuun MpMpocr
`
`Cl YaeTcd 3a CueT yBenHv4ennt MBIMeUHOH CHIBI. Pa3HOBHIHOCTBIO
`ABIMIOTCA “BSPHIBHAT CHA» (B. Poguonos, 1966; A.B. Danees,
`
`repMHHOM o603HadaroT cnocoGHOCTh
`JOCTHTaTh MakKCHMyMa
`
`
`
`Allergan, EX1083
`
`

`

`POABIICHHU B3PbIBHOM CHE BaXKHA He CTONBKO BeNM4MHa CHIBI, CKOJBKO eé
`
`
`HapacTaHve BO BpeMeHH, T.e. rpaqMenT CHI. PesyIbTATHBHOCTS BBINOTHCHHA
`CKOPOCTHO-CHIOBBIX ylpaxkHeHH TeM BEIe,
`4eM Mee [JIMTeMbHOCTS
`
`HapacTaHHa CHILI Jo e8 MakcuMambHoro sHayeHHa. B kayectse cnenHpuyeckoro
`
`tbaktopa HeKOTOpBIX CKOPOCTHO-CHJIOBBIX cnoco6Hoctelt CIlOpTCMeHa BBIJeLAIOT
`
`peakTMBHBIe CBOCTBa MBI. OHH MpOABILAOTCA B TBWKCHMAX, BKIOUAIONX
`
`MIHOBeHHOe MepeKmodeHue OT ycTynarowero K peofonepalonleMy PekUMy
`
`paOoTsI MBUUU, H XapakTepH3yIOTCA TEM, YTO BENMYHHA TpeORONeBAIOMHx youn
`
`cyljecTBeHHO BO3pacTaeT
`TOA
`BIHAHMeM MpeBapHTeHbHOTO 6EICTporo,
`
`«HpHHYTMTeNBHOTOpacTsrMBanua paOoTa¥ouMx MBILIN3a cuer KMHeTH4ecKolt
`
`
`9Hepruu mepememaromelica Maccsr (E.A.[lnpKosen, 2003).
`OT
`MakcumanbHai
`Npow3BOsbHai
`cla
`3aBHCHT
`
`(nepucepueckux) HW KOOPAMHAMOHHEIX (IleHTpasIbHO-HepBHBIX dbaxtopos) (A.M.
`Kon, 1986). K MbInIedHBIM (nepHbepw4eckHM) akTopaM, oOlIpeyesAOIIHM
`
`TIPOW3BONbHO pa3BHBaeMY!0 M@KCHMAalIbHY!0 CHIIy OTHOCATCH cnenyrouue: 1)
`
`WHa MBIII, MOCKONbKY yCHNIMe MBIbI 3aBHCHT OT Ce JIMHEI; 2) ycnoBHAa
`
`eijcTRUA MBIIesHOM Tara — Wiedo para JelicTBHA MBIeYHOH CHIBI HM YTou
`
`PHNOKeHuA ITOH CHII K KOCTHBIM pBrdaraM; 3) dusnonormeckui NonepedHUK
`(HaIOUMXCA MBI, B CBA3H C TeM, YTO MpH NpOdMx PaBHBIX YCHOBMAX
`
`3BHBAeMad MBILINeH CHa TeM 6onbite, vem Sonpute e& nomepewHuK; 4)
`
`Homlenve OBICTPEIX H MC/IICHHBIX MBIWC4HBIX BONOKOH B COKpallarollMxca
`lax, Tak Kak MIpOABIAeMad MBIWeYHaA CHa TEM Gombe, 4eM Sorbie B
`
`inarotlelica MBUNIe SLIcrpprx BooKOH (P.D. Collnick et al., 1981; E.A.
`
`
`PUMHAalMOHHEIC (e@HTpabHO-HepBHEIC) PakTOPh! BKOTAIOT B ce6a
`HOCTS WeHTpaNbHO-HepBHEIX MeXaHW3MOB YMpaBJICHHaA MbIWe4HBIM
`
`ATOM—M@X@HV3MBbI KOOPIMHalHU OTMENbHBIX WBHTaTeIbHBIX CHMHHIL (TE)
`
`MOKMBIedHOH KoopsMHallun. CrpyktTypHo-yHKiHOHaIbHar
`HPOHA@JIBHBIX ceTeH TONOBHOrO HM CNMHHOTO Mo3ra oGecreuuBaeT
`
`
`
`Allergan, EX1083
`
`

`

`MOLIHBIM Te
`
`
`HE OTIpeAEMALOT KONIMYeCTBO H YacTOTy HeEpBHBIX MMITYIIBCOB, TIOCTYIMArOWHXx B
`ckeslIeTHbIc MbINMIbI OT MOTOHEeMpOHOB
`ciMHHOTO MO3ra, H TCM CaMBbIM
`
`o6ecne4xHBaloT Tepexoy, OT cnaOpix OMHMHOUHBIX coKpaileHui MX BOJIOKOH K
`
`TAHHYCCKHM. C TMOMOMIbIO JaHHbIx Me€XaHH3MOB MO%KET TO
`
`MaKCHMasibHoe 3HadeHHe NpOHSBObHO pa3BuBaemoli MBIMMC4HOM CHIBI. Benwunna
`
`Ibl WeoBeka 3aBHCHT OT “CHIBI cokpaleHHa
`
`MIC oTnenpHo cKeweTHOM MBIII
`ApyrHx MBIT. MakcuMalibHad chia KOHKpeTHOH MBIIIMbI pasBHBacTCAa JIMUIb TIpH
`
`coBepilieHHoli MOQ)KMBIMeTHOH KOOpAMHAaIHy, oSecneduBalolie OnTHMalIbHBI
`
`BLIOOp MBI, - CHHeprcrtos, nOHWKeHHe AKTHBHOCTH MBIIMY — abTarOHHCTOB Mw
`
`OBbIIMNeHHe YCHIMH MBILIL, PUKCHpYyIOUIMX COOTBeETCTBYIOMNIMe‘CM@XxKHBIC CyCTABBI
`
`_ (f0.C. Canmcxac, 1990; B.H. Tonenxo, 1994; B.H. Kypsrcs, 2004; 1.B.
`
`Meapzezes, 2007).
`
`“TO yipaBicHue MBILIMaMu, Korga Tpedyetcs
`Cnemyer moguepkHyTb,
`
`ABNACTCA cnomKHow 3anadeH
`
`,OABUTS UX MAKCHMAJIBHBIC MIPOH3BONBHEIC ycuiua,
`Tlostomy, B OOBHHEIX YCNOBHAX MIIC
`
`Juin WeHTpanbHoit HepBHOH CHCTEMBI.
`YCUIMIMM, pa3BHBAaeMBIMH B OTBCT Ha
`
`MBIUIM MeHbIle B CpaBHeHHH c HX
`OCTHMYILALHIO CaMHX MBUII. PasHHIly MCKAY
`
`“TAHUIECKY!0 SEKTP
`alOT CHJIOBLIM e@ulATOM
`
`cunoil, BBI3bIBaeMO gneKpocTuMysaiven, Ha3biB
`M. Kon, 1986).
`
`wee leHTpalbHoe yipaBlenne MBILICYHEIM aliliapatoM, TeM
`
`Yem cosepiileH
`HBbIU
`BI. BenwanHa CHJIOBOTO
`
`e cuHroBon yeduuMT yaHHou MBIMeuHOH rpynit
`3MOUMOHaIbHOTO}COCTOAHHA
`
`ne“xonorm4eckoro,
`ulluTa
`3aBMCHT
`OT:
`a ONHOBpeMeHHO aKTHBHpyeMbIx MBIMe4HEIX PpyMt;
`eMoro; KOJIM4eCTB
`
`Ty Mpnuamu (41.M.
`copepmlieHcTBa yupaBiieHHt BOBIeUeHHBIMH B pa6o
`
`6; M.H.Stoneetal., 2007; D.J. Kidgell et al., 2010).
`
`pemieHHu J{BHIaTeNBHbIX 3aya4, TpeOyrolm4x NposBieHnHA passIHaHbIX
`
`@MBILNICUHEIX ycunui, MCHONB3YIOTCA TPH OCHOBHBIX Me€XaHH3Ma-
`
`eryIALHA KOMMUCCTBA AKTHBHBIX TIE;
`
`eT yIANMA YACTOTHI HMITyIbCalM MOTOHEHpOHoB;
`
`
`
`Allergan, EX1083
`
`

`

`Typdunxens,10.C. Jlesux, 1985; R.M. Enoka, 1988).
`
`1. Konmaectso aKTHBHEIX JBHTaTeIbHBIX eAMHHL. Tlockombky Kaxkaaa
`
`MBIUILa HHHEpBupyeTcaA MHOTHMH MOTOHespoHaMu, MMeIONIMMH pa3HEIe Moporn
`
`pekpyTHpoBaHHa, w3MeHeHHe “Mca aKTHBHEIX MoTOHeHpoHoB (J[E) sBmaeTCA
`
`BAXKHBIM CHOcO6oM perysMHH CHIBI COKpalleHus MBIMIN. C ysenmueHHem
`
`KONMUeCTBA AKTHBHEIX JIE BospacTaeT M pasBuBacmar TaHHo MBE CHa.
`
`B Havane 30-x rofoB mpowwioro Beka OBO ycTaHOBIeHo, yTo He}onbume
`
`MOTOHeHpoHBI, HHHEpBAPy!OMIMe Me/JICHHBIC MBILNIIBI, AKTABHPYIOTCA Erde, 4eM
`
`6omee KpyIHBIe MOTOHEHpOHE!, COCTABIIMONIHE 6uicTpHie JIE. Bompoc o mopaaKe
`
`pexpyTuposanua JIE Hav6onee Tomo w3y4ancn 9. XenHeMaHOM, KOTOpbIii
`
`yloKa3ayI
`HeW3MeHHOCTh
`HM
`CTepeOTHTTHOCTs
`nopayka
`akTHBalMl ME
`
`COOTBETCTBHH C
`pa3MepOM HX motToueliponos
`(E. Henneman,
`
`_ yBeuMueHveM MHTCHCMBHOCTH BOsOyKMAaOWHX BIMAHHH Ha MOTOH
`
`pepw4eckHx pellelTOpoB
`CTOPOHE! LeHTpasIbHBIX MOTOPHBIX cTpykTyp MW
`lepH
`
`pexge Bcero aKTMBMpyIOTCA Manenpkue, Memmennpte JIE. Ipu asibHehiiiem
`
`-ycnsieHun
`BOsOyKTAIOWIMX
`BIMAHHH
`B
`pa6oTy
`BOBJIeKalOTCA
`
`ycTowunppie
`K
`YyTOMJICHHIO
`JME.
`bpicrpsite,
`GEICTpO
`yTOMJIAeMBIC AE
`
`aKTHBUPY!IOTCA MOCIeTHAMH,
`IIpH MOCTWKEHHM CHJIbI COKpallleHHA B 20 — 25
`
`TIIPOWeHTOB OT MaKCHMaIbHoH.
`
`CnreqopatenbHo, Topayok aKkTHBalMH JIE onpemenserca coOcTBeHHBIM
`cBOHCTBOM HX MOTOHEMpOHOB — BeIMYMHOM: 4eEM MeHbIMe pasMep MOTOHEHpoHa,
`
`(pexpyTHpoBaHH®). SToT MpHHUMN akTHBalHi
`
`f HYKE Topor ero aKTHBalH
`yHelipoHOB HasbipaeTCA NPHHITATOM pa3sMepa WIM TIpHHUMMOM XenHemana.
`
`campre Masipie JIE MBILM[bI akTHBHBI pH juo60M eé
`nacho STOMY TIpHHLWAIly,
`
`eHMH, Tora Kak Sonpiuue, Srictppie JIE, Bxo_amue B cocTaB JaHHOl
`
`“aKTHBHBI JIMUIb pH OOMbUIMX YCHIHAX, [lostomy y OAHOH u Tol xe
`
`TeTeHb HCiHONB30BnaHHA OONbIIMX, 6uictpprx JIE mo cpaBHeHHIo ©
`
`e]ICHHBIMH e{MHMLaMH, MeHBITC (P.M. OHoKa, 1998).
`
`
`
`Allergan, EX1083
`
`

`

`
`MOTOHEHPOHLI JaHHOH MBIUILIbI, 3aBHCHT OT XapakTepa pelmaemoit aBuratebHOli
`gayaau (JLT. Kyauna, 1983; A.Jbx. Maxk-Komac, 2001; P.M. Caruros, 2001).
`
`Ecnv py BBINOHeHHH JBWOKeHHA MBIA }OIMKHa pa3sBUTb HeOOMBUTyIO CITY, TO
`
`K eé MoTOHe/ipoHaM TlocTynaeT cnaOblii MOTOK HEpBHBIX HMIYJIBCOB. B cBa3u c:
`
`TeM, 4TO B CocTaB jOGOH MBIINMEI BXOMAT H 6uicTpHie, H MegseHHIe JIE,
`
`OTIHNAIOWMecd pa3MepaMi CBOHX MOTOHeHpoHos, peakiMa JIE wa STOT MOTOK
`
`HepBHBIX MMIyJIbCOB pasJIM4Ha. AXTHBHOCTS BOSHMKaeT JIMIIb B MemweHHEIX JIE,
`
`WMeCFOLUIMX Hebonpume pa3sMepbi MOTOHeHpona, a, CHeOBaTebHO,
`
`
`TOporH pekpyTHpoBaHHa. Brictppie JE y aHHO MBIIIbI B 9TOM cydae He
`axruspupyiortcs. [ostomy quatla30H cnaObix ycMBIIUEI obectexMBaeTcA
`
`_AKTHBHOCTHIO TOJIBKO MCJVICHHEIX, YCTOHUHBBIX K YTOMJICHHIO JE (rum S).
`
`Tip BEINOTHeHHH ABWKCHHA, Tpe6yromero SombWIOH CHIBI COKpailleHHA
`
`eé MOTOHeCHPOHbI MOABepraroTcH posgelictauio Gomee
`nannoli MBILILBI,
`
`1976). Oto TIpHBOAHT K
`WHTe€HCHBHOFO TIOTOKa HepBHBIX MMITYJIBCOB (P.C. Tlepcon,
`
`peNMYeHHIO YCIa AKTUBHPYIOWIMXcA JIE. Kpome MefJleHHEIX, HH3KOMOpOroBbix
`
`: BKIOWAIOTCA B pa6oty u GBICTpbIe BBICOKOMOpOroBbie JE. Ye
`
`wii Ha MOTOHCHPOHEI, TeM
`ospactaeT HHTCHCHBHOCTB BO3OYKTalOLIMX BMA
`
`ee ‘KpyoHBIe mo pa3smMepy
`JIE sopnexaiorca B padory.
`CrenoBaTeibHo,
`
`a COKpallleHWa MBIUILMBI oSecneunBaeTca akTHBHOCTEIO JIE Bcex
`
`WTeNbHaI CHI
`
`exTuros(S, FR, FF).
`-.“actota YMITyIpcalHH +MOTOHEHPOHOB. Tipu cna6om coKpallicHHH
`
`THEIX MBIT wacToTa MMMyJIbCallHH COCTaBILAcT 5 — 10 Ty. B TaxoM
`a30HeYaCTOT Wake Me/JICHHBIC JIE GonbuiMHcTBa MBIUIL paSoTaroT B pexuMe
`
`0TeTAHYCa WIM WaxKe OAMHOUHOTO COKPaLIeHHA. [nankoctb coxpallleHua
`
`
`mur+oGecnewuBaeTcH B STHX YCHOBUIX HeOHOBpeMeHHOCTHIO
`
`
`NOHHOCTBIO) AKTHBHOCTH pasHBIX HIE.
`BeNHYCHHEM CHIBI COKpallle¢HHa MPI! yacToTa pa3pAJ0B WE
`
`YW.Amannnac, 1983). [pu cune coxpalleHua, paBuoli 30 % — 60 %
`
`ol, wacrota uMiynEcaumH JE gocruraer 20 — 30 Tu, a mp
`
`
`
`Allergan, EX1083
`
`

`

`
`cokpallleHua, MrHOBeHHaa YacToTa MMIMyJIbCalu nocturaet 90 Ty u gaxe 120
`
`Tu. VW3noxKeHHble BbIIMe akTbI WoKa3sbipaioT yuacTue MeXa@HH3Ma H3MCHCHHA
`
`qacToTsI uMnynEcayHn JIE B pery1alMM CHIBI CoKpallleHHa mpi. Gem BBIe (0
`
`onpefemeHHoro mpeyena) yacToTa MMITybCalHH otnenpHol JIE, Tem Ooubute
`
`cua coKpallieHaa e& MBIIeYHBIX BOIOKOH H TEM Goble eé BKIay B pasBHBaeMoe
`
`pceii Mniminei ycunne. [iat Kaxqot otyembHol JIE xapakTepHO onpeyeneHHar
`
`H KOTOpOH CHJIOBLIe BO3MO2XKHOCTH BCCX eé MBIIMC4HEIX
`
`_-qacTOTa MMIYJIBCOB, Mp
`_ ponoKoH peamm3y1oTes MomHocTaIO. Perysalua CHIBI coKpallleHHa MBIMIMIbI MyTeM
`
`_ YSMeHeHMA YacTOTHI MMMTECALIMH JIE nanOosee BbIpaxkeHay 6nicTpprx JE.
`
`Yactrota Bo3s0y2xeHHA oTuembHow JIE ompemessaetca WHTCHCHBHOCTBIO
`
`‘Hexonarmero TOTOKa HepBHEIX MMIyIbCOB, BOsTeHicTByIoMlero Ha MOTOHEIpoH
`
`
`nannoli TE. Ecnw WHTeHCHBHOCTS Bo36y2Kalo
`ie MequieHHBIe JIE, KoTOpbIe HMITyIBCMPYIOT C
`BITHOUAIOTCH JIMUIb HA3KONOpOToB
`
`THOCHTEEHO H
`eBBICOKOM YacTOTOH, MocTaTOuHOH ANA oGecneveH
`
`akaa yactota uMnynpcanuu JE
`
`_MHOUHOTO coKpalljeHHa 4 3y6uatoro TeTanyca. T
`
`
`sCHleuMBaeT cokpaliyjeHHe MBIMbI=C yMepeHHolt cunok
`
`OMOIMKHTeIbHOTO BPeMeHH. Vimenno B 3TOM jMama30He padoTaIoT AE
`
`IETHBIX MBIMIL pH noALepxaHHy BepTHkasIbHowi 110
`
`CHIBI
`COKpalijeHHa MBILINb! wocruraeTca
`
`
`Tarolyax BIMAHHH Ha eé MOTOHeMPOHBI.
`HCHBHOCTH Bo30yX,
`BHIX BKIOUAIOTCA B padoTy BbICOKOMOpOrOBBIe 6pictprie JIE, wactrota
`
`TrynBcalluu KOTOpBIX BospactTaeT C TOBLILNCHHEM HHTeCHCHBHOCTH WOTOKAa
`
`xXVMITYIBCOB K MOTOHeMpoHaM STHX TE (B. Calancie et al., 1987).
`
`MajbHad CHa COKpalleHWa MBIIIIIbI mocturaetca B TOM cyydae, Kora
`
`wMnyIBcaluu
` B
`6onRIIMHCTBe BBICOKOMOporoBBIx ObICTPBIX TE
`
`BaeT cokpalyjeHnHe MX MBIMIeYHBIX BOJIOKOH B pexKHMe
`TIpofomxuTenbHOCTh MoAmepkaHHA coKpalenvit c TaxoH cHIIOH He
`
`TMX BIMAHMM HeBeluKa, TO
`
`
`
`_ Ypenmuenne
`
`3b] TENA.
`
`Allergan, EX1083
`
`

`

`yBeIM4eHUA YaCcTOTE! HMMynbcaMM JIE c yBemMucHHeM YCHJIMA MBLILUBI tpe6yeT
`
`3HaHuit O MAKCHMaJIbHEIX BO3MO2KHOCTAX KaxkKZOro M3 HUX. ConocTaBieHHe CHIBI
`
`COKpallleHHa MBIT mp camo HU3KOl
`dacTOTe
`uMMysIbcallun ux JIE
`
`(ycpeqHeHHow cumpi 3yOuaToro TeTaHyca) c CHO, pasBuBaeMol NIpH BbICOKOH
`
`yacToTe MMIyibcalMu (riagKoro TeTanyca), Moka3a0,
`4TO TNOcNeqHAA B
`
`HeCKONBKO pa3 Gombe. CieqoBaTebHO, pexpyTHpoBaHHe pceex JIE lp Hu3Koi
`
`yacToTe HMIyipcaluu oOeche4HBaeT MeCHBINMH IpHpocT CHIBI, FEM TOT, KOTOpBIM
`
`
`Baer YBCNMYCHHe UacTOTHI. ro o3sHayaeT, YTO B Ppa3sBHTHe CHIIbl coKpalleHHA
`-MaAKCHMaNbHBIe BO3MOXKHOCTH YacTOTHOTO MexaHH3Ma OoubHIe MaKCHMA@JIbHBIX
`
`-Bo3MoxHOCTel MexaHH3Ma pexpyTHpoBaHUus. B pa3HaqHBIXx juana3oHaX CHIBI HB
`
`
`PaSHBIX YCNOBHAX COKpallleHHA BOSMOXKHO Kak TlapasienbHOe HCHONL3IOBAHHE
`oG0HX MeXaHH3MOB ANd yBeuMdcHHA CHIBI MBIIMeyHOrO cOKpailleHHa, TaK H
`
`
`TIpeuMyllectaeHHoe VCHONB30BaHMe OHOTO W3 Hux. B peasbHbIxX YCMOBMAX
`MBIMeUHOM eaTenpHOcTH ueNOBeKa Goybillat dacTb JTE axrupupyetca B
`
`vamaz0He oT 0 % 0 50 % MaKCHManbHOH CHuIbI cOKpallleHHa, Noce wero
`
`BUICKACTCH mau we6ompmoe
`(oKono
`10 %)
`xkomMuecTBO HavOooee
`
`
`COKOMOporoBsIx JIE, a yBemwuenne cub oT 75 % 20 100 % yocruraeTca
`
`cxmoumrenbHo 3a cueT pocTa YacTOTBI MMITyEcalHH (A.A. [HAHKOB, 1975; P.C.
`
`cou, 1985; B.C. Pyp@uukesp, 1O.C. Jesux, 1985; 7].A. Merpos, 2001).
`
`3. CwHxpoHMsatiaa COKpallleHHa MBIIICYHEIX BOJIOKOH oTmempHEIX J[E BO
`
`MeHH. ~Coxpatienvie MBILIUSI BCerga ocyilecTBIaeT¢ca Mpu AKTHBHOCTH
`IBKUX VI MHOTHX JIE. Xapaxtep BpeMeHHOH B3aMMOCBA3H aKTHBHOCTH
`
`
`woHEx JJE B opefemenHo Mepe BIIMaeT Ha CHJIy COKpalleHHa MBILLILLBI.
`jeHne BO BPeMeHH OTeCNbHEIX HMIYIbCOB ABYX van Gosee JIE Ha3pipaeTcx
`
`eared (P.C. Tlepcou, 1985; M.L. Foss, S.J. Keteyian, 2008).
`
`DHA ‘BIMAHHe CHHXpOHH3alHM Ha CHIy COKpalljeHua Ha NpHMepe Tpex
`«1 aa “3 Tpex JIE coxpalllaeTca CHHXPOHHO C ApyTHMy H paOoTaeT B
`
`IOYHOTO COKPallleHHA, TO COKpallleHHe MbIICHHEIX BOJIOKOH KaxKqoH
`
`T ¢ coKpallenvem Apyrux JIE. CneqopatesbHo, coxpalleHHa Tpex
`
`
`
`Allergan, EX1083
`
`

`

`oTnenbupix JIE W MBIIIIja pasBHBaeT CpaBHHTeIbHO Gonpityro cury. HaoSopot,
`
`ecnu tpu JIE coxpamatorca acHHxpoHHo (He ONHOBpeMeHHO), TO CyYMMalIMM He
`
`TIpOMCXOZMT H MbIWa
`pa3BHBacT MeHBITyIO culy. B ‘WepBoM cJilyaae
`
`HaOuOMAlOTCH 3HATHTeNbHbIe KoeOaHMA CHJIbI MBIMeYHOrO COKpallleHH, BO
`
`
`BIOPOM OHM CYIIeCTBeHHO MeHbIlle. OTOT MpHMep CBHCTENBCTBYCT O TOM, 4TO
`pu padote JE B pexXMMe OfMHOYHOTO COKpalleHHt ACHHXPOHHOCTh HX
`
`-@KTMBHOCTH
`oG6ecneuuBaeT
`CIIaxKCHHOCTb
`cokpaleHHii
`BCeH MbILIIIHI.
`
`
`-Ypenwuenue uucna acuHxponHo paGotaioujux JIE mpHBOAMT K YMeHPIICHHIO
`_KomeGannit B HallpsKeHHH MbILILPbI,
`qTO cnocoOcTByeT 6onee
`
`
`“BRIMONHeHMIO HM TOUHOMY MOsepxKaHvlo TOK WI. WHOK mosb. B ecTeCTBCHHbIX
`YCNOBUAX 2KM3HEMEATEBHOCTH 6onpmuHcTBO JIE MbIIMIbI paboTaioT aCHHXPOHHO.
`
`3a
`c¥eT STOTO JOCTHTaeTCA CraKeHHOCTb COKpalleHHA MBIIII B yCIOBHAXx, Kora
`
`prueuHpIe BonokHa JIE 3-34 HH3KOM YacTOTb! MMITybcallvu MOTOHEHPOHOB
`
`
`paOoTaioT B pexkHMe OAMHOHOTO COKpalleHHA WM 3y6uaToro TeTaHyca.
`HopMasipHad
`BpeMeHHan
`CBA3b
`@KTMHBHOCTH MBIMICdHbIX
`
`JIBHBIX JIE HapyliaeTca IPH MBbIIeCYHOM YTOMJICHHH. 37To mposBAeTCA B
`epHonMteckOM rpynmuposanun («cryeHHM) HMITYIBCOB pasHBIX HE. B raxux
`
`BHI TepACTCH MMABHOCTS HM TOYHOCTh BBIMOMHACMOTO ABWKCHUA H BO3HUKaCT
`
`) yTOMMIeHHA — JPOXKATeNBHBIe ABMKCHHA C OTHOCHTECIIBHO Sonbwi0k
`
`WMTy HOH (10.C. Cammucxac, WW. Amanunac, 1980; J]. Kosapos, 10.T.
`
`3,1983; 10.T.Ianxos,1984).
`
`
`1
`[WE paOotator B pexkuMe TlayKoro TeTaHyca, xapakTep CBA3H MX
`
`CTHBO BPeMeHH He OKaSbIBaeT CKOJIb — M60 CyWMeCTBCHHOTO BIIMAHHA Ha
`BHBaeMOTO MEIUMe CTaTH4YeCKOTO YCHIHA. ITO CBAZAHO C TEM, 4TO
`ce_Teranyee cyla cokpaleHHd KaxKnoi 43 padotaromjelt TE
`
`
`TCHTipakraecku=Ha TOCTOAHHOM —YPOBHE. Tlostomy mp
`
`JLHTeNTBHIX Wo
`CHUIBHBIX COKpailleHuax MBILbI
`
`BOBpeMeHH YMMYIbCHOH aKTMBHOCTH pasHBIX JIE dbaxTH4ecKH
`ia
`aKCHMA@JIbHOM younMEE (P.M. Dopoguuues, 2005).
`
`
`
`Allergan, EX1083
`
`

`

`cokpalleHHAax nin B TlepBbI MOMeHT J060ro cokpallleHHa, Tak Kak BJIMACT Ha
`
`CKOPOCTb pa3sBHTuA coKpalieHHa. EctecTBeHHO, AUTO UCM 6onpuie COBMAaarwT
`
`TeNbHBIC WMKIE pasHErx JIE B mepBonayabHBI nepHor coKpallieHHA
`
`coxpaTu
`Husa ObICTPLIX JBHOKeHUE,
`
`MBIMUIEL, TEM ObIcTpee OHO HapactaeT. Buatase BBIMONHe
`CBA3aHHBIX Cc
`IipeoqOuIeHHiemM 3HAYHTenbHOH BHemmHeli Harpy3kH, OOETHHO,
`
`HaOmomaercd APKO BBIPAKeHHAad CHHXPOHM3aluz yMitynbcHo axrupyocty JIE.
`
`3ro B cylectBeHHOM cTemeHH onpe/emseTcn TEM, YTO B TiepBbIlt MOMeHT
`
`ea3allul IBYOKeHHA WacToTa pa3pz0B BbIWIe, YEM B MOCJIICTYIOWCM.
`
`Bricoxad NepBpoHatasibhHan yacToTa HMITYIbCalHn H aKTHBHOCTB 6o0bLIOTO
`
`KomMuecTBa
`MOTOHeEHPOHOB
`cnoco6cTBY!tOT
`yBeIM4eHHIo
`
`\BUATCHHA COKPAaTHTCNbHBIX WAKIOB pasHbix TIE B mpollecce pasBHTHA YCHIIMA.
`CKOpocTb pa3BHTHA cokpatlleHHaA MBIIMUEI 3aBHCHT Kak OT
`
`Takum o6pa30M,
`of
`4acTOTHl
`
`KonmaecTBa
`aKTHBHEIX JIE, Tak
`HM OT HadalibH
`CHHXPOHH3AlMH HMITYIbCHOM aKTHBHOCTH MOTOHEeHPOHOB aHHOM MBIIILEL.
`
`
`
`1.2. Meroabt pasBuTHa MBIMMeTHOH CHJIbI
`
`
`
`OBLIMeHHe CUNOBBIX croco6HocTei TIpOMCXOMMT HMIb. TOrHa, kKorga
`
`CHM@JIBHBIe ~MbIMICHHBIC HarlipwKeHHA. Tlostomy OCHOBHaA
`
`BIMIOTCA Mak
`yTo6EI O6ecre4HTb B
`
`a , MeTORHKe CHJIOBOH MONTOTOBKH COCTOMT B TOM,
`LECCE BBINIONHeHHA yipaxHeHHii HOCTaTOuUHO BBICOKY¥0 CTeMeHb MBILICUHBIX
`
`ui (JL10. bpapaa, 1985; B.H. Tonenxo, 1994; A.B. @anees, 2006;
`
`mH, 2010; 10.M. Tpumuna, 2012; 10.8. Bepxomancxul, 2013). B
`
`yeHMPOBOUHBIX porpaMMax MIpHMeHAIOTCA pa3IMdHBIe croco6sI
`yOmakcaMambHBIx
`Mo MaKCHM@JIbHBIX HallpspKeHHH: NOJHHMaHHe
`
`yTATOMeHUM HeOombiIi0e YHCIO pas; TIOMHHMaHHe HelpesesbHOTO
`
`
`
`Allergan, EX1083
`
`

`

`
`
`
`
`
`
`CONpPOTHBNeHHH Mp NocTOsHHOM TMHe MBIMIM; CTHMyMpoBaHHe COKpallleHHsA
`MBIIMIBI 3a CYeT BeCa Mafaiomero rpy3a uM coOcTBeHHOTO Tena u gp. (B.B.
`Kysnenos, 1975; AJI. Kpusenyos, 1987; 10.B. Bepxomancxui, 1993; B.H.
`TInatonos, 1997; B.H. Kypsics, 2004; A.A. Bacunenxo, 2006; A.B. Boponos u
`mp., 2006; A.J]. Manuranun u ap., 2011).
` BorpocaM CHIIOBOH
`fMocBAeHHOH
`B
`cospemenHoli
`sMTepaType,
`
`
`TONTOTOBKH,
`OOBTUHO
`BbIZeMMIOT CieMyrouMe MeTOTbI
`pasBHTHA CHUIBI:
`
`‘W3OMeTpHuecKkHHi,
`KOHWeHTpHdeckui,
`9KCHCHTpH4ecKHH,
`#M30KMHETH4eCKH
`(TbK.X, Yunmop, JI.JI. Kocrun, 1997; M.H. Stone et al., 2007; AB. Camconosa,
`
`2011; P. Houber, 2011).
`
`Vsometpuuecknit MeToy pexycMaTpuBaeT HaNpsaKeHve CKENCTHBIX MBILLI
`
`
`6e3 W3MeHeHMA
`UX
`IMHEI, Up HenOaBMXKHOM MONO%KeHHH
`
`3omMeTpH4eckuii MeTOJ IPHBOLUT K MIpUpocty CHJIbI, IpOABAeMOM B OCHOBHOM B
`
`om CyCTaBHOM yTule, B KOTOPOM OCYyIMeCTBIAeTCA TPeHHPOBOUHOE yiipaxKHeHHe.
`
`jemyer YUATEIBATS, 4TO CHINA, pHoGpereHHad B pe3yIbTaTe TaKHX CHJIOBBIX
`
`HMPOBOWHEIX iporpamM, cna6o pacipoctpanserca Ha padoTy WHHaMHueCcKOrO
`
`akTepa. Tip w3omeTpwueckoll
`IpeHHpOBKe MpHpocT CHJIOBBIX KayecTB
`
`IDOBOKMACTCH YMCHBIICHHE CKOPOCTHEIX BO3MOXHOCTeH CNOPTCMeHOB, “TO
`
`TIPOABNAeTCA Yepe3 HECKOJIBKO HeJenb cunoBol rpenuposKu (A.H. Bopo6ses,
`9 3.E. Uypcuuos, 2011).
`|
`
`Ha
`Konuertpyuecknti MeTO OCHOBaH
`BBINONHeHHH MH3HYCCKHX
`
`ipaxkHeHU c MpeoyomenaiowumM xXapakTepoM padoTbl H OHOBpeMeHHBIM
`
`VeM MBILU, H coKpaljeHvem ux LyIMHbI. [IpBMonHeHHM yipaxHennit
`
`leHMaMM (mraHrot, HaOHBHSIMH Ma¥aMM HM Ap.) COMpOTHBNeHve He
`
`HACTCA Ha MPOTWKEHMM BCerO ABHXKCHHA. HloctymHocts MeTOya
`
`0BBICOKOT ero 3tdekTHBHOCTH, NpocTota MpHMeHAeMOrO TIPH 9TOM
`
`AQ TIOSBONAIOT PCWlaTb 3agaiu TBMraTeIbHOK TIONTOTOBKH, cBa3aHHOM
`
`
`
`Allergan, EX1083
`
`

`

`Ky3ueuos, 1