1.57
`1.58
`1.58
`1.59
`1.60
`1.61
`2.11
`2.13
`2.14
`2.26
`2.45
`2.49
`2.50
`2.50
`2.50
`2.51
`
`3.37
`
`4.28
`4.30
`4.62
`4.64
`7.07
`7.08
`7.08
`7.09
`7.09
`7.11
`7.11
`7.11
`7.23
`7.23
`7.24
`7.25
`7.25
`7.26
`7.27
`7.28
`7.28
`7.29
`7.36
`7.38
`7.38
`7.39
`7.40
`7.41
`8.17
`
`12.52
`
`
`
`2111KEYS.278A
`13XP034
`DMSO, H-1
`NUMEGA, 12-20-2021
`
`2.01
`
`1.03
`2.96
`2.93
`
`0.21
`
`1.01
`
`1.01
`
`0.97
`2.01
`1.00
`
`1.00
`
`0.95
`
`13
`
`12
`
`11
`
`10
`
`9
`
`8
`
`7
`f1 (ppm)
`
`6
`
`5
`
`4
`
`3
`
`2
`
`1
`
`0
`
`EISAI EXHIBIT 1056
`Eisai v. Crystal Pharm.
`PGR2021-00047
`
`Page 1 of 34
`
`
`1.58
`1.58
`1.59
`1.60
`1.61
`2.11
`2.13
`2.14
`2.26
`2.45
`2.49
`2.50
`2.50
`2.50
`2.51
`
`3.37
`
`4.28
`4.30
`4.62
`4.64
`7.07
`7.08
`7.08
`7.09
`7.09
`7.11
`7.11
`7.11
`7.23
`7.23
`7.24
`7.25
`7.25
`7.26
`7.27
`7.28
`7.28
`7.29
`7.36
`7.38
`7.38
`7.39
`7.40
`7.41
`8.17
`
`12.52
`
`
`
`2111KEYS.278A
`13XP034
`DMSO, H-1
`NUMEGA, 12-20-2021
`
`2.01
`
`1.03
`2.96
`2.93
`
`0.21
`
`1.01
`
`1.01
`
`0.97
`2.01
`1.00
`
`1.00
`
`0.95
`
`13
`
`12
`
`11
`
`10
`
`9
`
`8
`
`7
`f1 (ppm)
`
`6
`
`5
`
`4
`
`3
`
`2
`
`1
`
`0
`
`EISAI EXHIBIT 1056
`Eisai v. Crystal Pharm.
`PGR2021-00047
`
`Page 1 of 34
`
`
`
`7.07
`7.08
`7.08
`7.09
`7.09
`7.11
`7.11
`7.11
`7.23
`7.23
`7.24
`7.25
`7.25
`7.26
`7.27
`7.28
`7.28
`7.29
`7.36
`7.38
`7.38
`7.39
`7.40
`7.41
`8.17
`
`12.52
`
`
`
`2111KEYS.278A
`13XP034
`DMSO, H-1
`NUMEGA, 12-20-2021
`
`0.97
`2.01
`1.00
`
`1.00
`
`0.95
`
`12.5
`
`12.0
`
`11.5
`
`11.0
`
`10.5
`
`10.0
`
`9.5
`f1 (ppm)
`
`9.0
`
`8.5
`
`8.0
`
`7.5
`
`7.0
`
`6.5
`
`Page 2 of 34
`
`
`
`1.57
`1.58
`1.58
`1.59
`1.60
`1.61
`
`2.11
`2.13
`2.14
`2.26
`2.32
`2.38
`2.45
`2.49
`2.50
`2.50
`2.50
`2.51
`2.58
`
`3.37
`
`4.28
`4.30
`
`4.62
`4.64
`
`
`
`2111KEYS.278A
`13XP034
`DMSO, H-1
`NUMEGA, 12-20-2021
`
`2.01
`
`1.03
`
`2.96
`
`2.93
`
`3.0
`
`2.8
`
`2.6
`
`2.4
`
`2.2
`
`2.0
`
`1.8
`
`1.6
`
`1.4
`
`0.21
`
`3.4
`
`3.2
`f1 (ppm)
`
`1.01
`
`1.01
`
`5.0
`
`4.8
`
`4.6
`
`4.4
`
`4.2
`
`4.0
`
`3.8
`
`3.6
`
`Page 3 of 34
`
`
`
`2.49
`2.50
`2.50
`2.50
`2.51
`
`3.34
`
`5.83
`
`6.43
`6.43
`6.44
`6.45
`7.29
`7.29
`7.30
`7.31
`7.32
`7.33
`7.84
`7.84
`
`
`
`2111KEYS.278B
`A303477-015
`DMSO, H-1
`NUMEGA, 12-20-2021
`
`1.74
`
`2.33
`
`1.14
`
`1.10
`
`1.00
`
`10.0
`
`9.5
`
`9.0
`
`8.5
`
`8.0
`
`7.5
`
`7.0
`
`6.5
`
`6.0
`
`5.5
`
`5.0
`4.5
`f1 (ppm)
`
`4.0
`
`3.5
`
`3.0
`
`2.5
`
`2.0
`
`1.5
`
`1.0
`
`0.5
`
`0.0
`
`-0.5
`
`Page 4 of 34
`
`
`
`5.83
`
`6.43
`6.43
`6.44
`6.45
`
`7.29
`7.29
`7.30
`7.31
`7.32
`7.33
`
`7.84
`7.84
`
`
`
`2111KEYS.278B
`A303477-015
`DMSO, H-1
`NUMEGA, 12-20-2021
`
`2.33
`
`1.14
`
`1.10
`
`1.00
`
`8.0
`
`7.9
`
`7.8
`
`7.7
`
`7.6
`
`7.5
`
`7.4
`
`7.3
`
`7.2
`
`7.1
`
`7.0
`
`6.9
`
`6.8
`6.7
`f1 (ppm)
`
`6.6
`
`6.5
`
`6.4
`
`6.3
`
`6.2
`
`6.1
`
`6.0
`
`5.9
`
`5.8
`
`5.7
`
`5.6
`
`Page 5 of 34
`
`
`
`2.49
`2.50
`2.50
`2.50
`2.51
`
`3.34
`
`
`
`2111KEYS.278B
`A303477-015
`DMSO, H-1
`NUMEGA, 12-20-2021
`
`1.74
`
`3.8
`
`3.7
`
`3.6
`
`3.5
`
`3.4
`
`3.3
`
`3.2
`
`3.1
`
`3.0
`f1 (ppm)
`
`2.9
`
`2.8
`
`2.7
`
`2.6
`
`2.5
`
`2.4
`
`2.3
`
`2.2
`
`2.1
`
`Page 6 of 34
`
`
`
`
`
`" A KEYS 2 > g
`
`
`
` NuMega
`
`Company:
`Address:
`
`Key Synthesis LLC
`
`11526 Sorrento Valley Road Ste.B2 -
`804 Primrose Lane
`_ San Diego, CA 92121
`Wynnewood, PA 19096
`nm|Tel: (858)793-6057 Fax: (858)793-2607
`ey http://www.Numegalabs.com
`610-367-3281
`Fax:
`Numegalab@numegalabs.com
`Telephone:
`Ron Bihovsky
`Date: PA 7/21
`Name:
`
`
`PO# PDFLXJand rpL_|DI/247 Email: rbihovsky@keysynthesis.qqg™
`
`
`
`Sample ID
`
`Elemental Analysis
`Theoretical %
`please continue*
`
`pusxpo3sY|IH las
`ABO3477-Ol8_|'H |d7,54|
`
`olmle[eof
`
`* Elemental Analysis (3 mg per run) Single Duplicate: ||
`NMR (PDF):
`-0.5 to 10 ppm,integration, peak picking for H-1, 0-200 ppm, peakpicking for C-13. (FID: please request)
`Chemical shift (H-1). TMS (0), DMSO (2.50), CDCI,(7.26), or DO (4.78).
`
`Mass: Img in ImLor 20-50 UM, positive and negative modes. Please specify MW range.
`
`our Instructions /Remarks: (Hygroscopic, Explosive, Volatile, Toxicity, Storage, EA theoretical %, etc.)
`
`Routine NVR
`
`
`
`
`
`
`Analyst:
`
`Page7 of 34
`
`Date
`
`.
`
`Total Charge:
`
`$
`
`Page 7 of 34
`
`
`
`1.49
`1.50
`1.51
`1.51
`1.69
`1.70
`1.70
`1.71
`2.03
`2.38
`2.50
`2.50
`2.51
`2.69
`3.32
`
`4.28
`4.30
`4.67
`4.69
`
`7.11
`7.11
`7.39
`7.40
`7.40
`7.42
`7.43
`7.44
`7.45
`7.46
`7.64
`7.64
`7.66
`7.88
`7.89
`7.90
`7.91
`8.13
`8.32
`8.33
`
`11.21
`
`
`
`2111KEYS.469A
`13-141-1D
`DMSO, H-1
`NUMEGA 12-30-2021
`
`1.09
`1.11
`3.15
`0.41
`3.13
`0.35
`1.08
`1.92
`
`2.56
`
`1.13
`
`1.09
`
`1.12
`3.26
`1.04
`1.00
`1.12
`1.00
`
`1.03
`
`12.0
`
`11.5
`
`11.0
`
`10.5
`
`10.0
`
`9.5
`
`9.0
`
`8.5
`
`8.0
`
`7.5
`
`7.0
`
`6.5
`
`6.0
`5.5
`f1 (ppm)
`
`5.0
`
`4.5
`
`4.0
`
`3.5
`
`3.0
`
`2.5
`
`2.0
`
`1.5
`
`1.0
`
`0.5
`
`0.0
`
`-0.5
`
`Page 8 of 34
`
`
`
`11.21
`
`
`
`2111KEYS.469A
`13-141-1D
`DMSO, H-1
`NUMEGA 12-30-2021
`
`10.9
`
`10.8
`
`10.7
`
`10.6
`
`10.5
`
`10.4
`
`10.3
`
`10.2
`
`10.1
`
`10.0
`
`9.9
`
`9.8
`
`1.03
`
`11.2
`11.1
`11.0
`f1 (ppm)
`
`12.4
`
`12.3
`
`12.2
`
`12.1
`
`12.0
`
`11.9
`
`11.8
`
`11.7
`
`11.6
`
`11.5
`
`11.4
`
`11.3
`
`Page 9 of 34
`
`
`
`7.09
`7.09
`7.09
`7.10
`7.10
`7.10
`7.11
`7.11
`7.12
`7.12
`7.12
`7.13
`
`7.39
`7.39
`7.40
`7.40
`7.42
`7.43
`7.44
`7.45
`7.46
`7.46
`7.62
`7.63
`7.64
`7.64
`7.65
`7.66
`
`7.88
`7.89
`7.90
`7.91
`
`8.13
`
`8.32
`8.33
`
`
`
`2111KEYS.469A
`13-141-1D
`DMSO, H-1
`NUMEGA 12-30-2021
`
`1.12
`
`3.26
`
`1.04
`
`1.00
`
`1.12
`
`1.00
`
`8.5
`
`8.4
`
`8.3
`
`8.2
`
`8.1
`
`8.0
`
`7.9
`
`7.8
`
`7.7
`f1 (ppm)
`
`7.6
`
`7.5
`
`7.4
`
`7.3
`
`7.2
`
`7.1
`
`7.0
`
`6.9
`
`Page 10 of 34
`
`
`
`4.28
`4.30
`
`4.67
`4.69
`
`
`
`2111KEYS.469A
`13-141-1D
`DMSO, H-1
`NUMEGA 12-30-2021
`
`1.13
`
`1.09
`
`6.6
`
`6.5
`
`6.4
`
`6.3
`
`6.2
`
`6.1
`
`6.0
`
`5.9
`
`5.8
`
`5.7
`
`5.6
`
`5.5
`
`5.4
`
`5.3
`5.2
`f1 (ppm)
`
`5.1
`
`5.0
`
`4.9
`
`4.8
`
`4.7
`
`4.6
`
`4.5
`
`4.4
`
`4.3
`
`4.2
`
`4.1
`
`4.0
`
`Page 11 of 34
`
`
`
`1.49
`1.50
`1.51
`1.51
`1.69
`1.70
`1.70
`1.71
`
`2.03
`
`2.20
`2.22
`2.25
`2.38
`2.45
`2.49
`2.50
`2.50
`2.51
`2.51
`2.62
`2.63
`2.63
`2.64
`2.69
`
`3.32
`
`
`
`2111KEYS.469A
`13-141-1D
`DMSO, H-1
`NUMEGA 12-30-2021
`
`1.09
`
`1.11
`
`3.15
`
`0.41
`
`3.13
`0.35
`
`1.08
`
`1.92
`
`2.56
`
`3.6
`
`3.5
`
`3.4
`
`3.3
`
`3.2
`
`3.1
`
`3.0
`
`2.9
`
`2.8
`
`2.7
`
`2.6
`
`2.5
`
`2.4
`
`2.3
`
`2.2
`
`2.1
`2.0
`f1 (ppm)
`
`1.9
`
`1.8
`
`1.7
`
`1.6
`
`1.5
`
`1.4
`
`1.3
`
`1.2
`
`1.1
`
`1.0
`
`0.9
`
`0.8
`
`0.7
`
`0.6
`
`0.5
`
`Page 12 of 34
`
`
`
`1.50
`1.50
`1.51
`1.69
`1.70
`1.71
`1.72
`2.03
`2.30
`2.38
`2.69
`2.73
`2.89
`3.33
`
`4.28
`4.30
`4.67
`4.69
`
`7.16
`7.18
`7.23
`7.25
`7.39
`7.40
`
`8.13
`8.32
`8.33
`
`11.22
`
`
`
`2111KEYS.469B
`13-142-1E
`DMSO, H-1
`NUMEGA 12-30-2021
`
`1.07
`1.08
`3.12
`3.10
`3.11
`1.05
`3.82
`1.52
`1.63
`
`1.76
`
`1.15
`
`1.13
`
`1.26
`0.46
`2.18
`1.96
`2.13
`1.12
`1.05
`1.00
`0.45
`1.09
`1.00
`
`1.02
`
`12.0
`
`11.5
`
`11.0
`
`10.5
`
`10.0
`
`9.5
`
`9.0
`
`8.5
`
`8.0
`
`7.5
`
`7.0
`
`6.5
`
`6.0
`5.5
`f1 (ppm)
`
`5.0
`
`4.5
`
`4.0
`
`3.5
`
`3.0
`
`2.5
`
`2.0
`
`1.5
`
`1.0
`
`0.5
`
`0.0
`
`-0.5
`
`Page 13 of 34
`
`
`
`11.22
`
`
`
`2111KEYS.469B
`13-142-1E
`DMSO, H-1
`NUMEGA 12-30-2021
`
`11.10
`
`11.05
`
`11.00
`
`10.95
`
`10.90
`
`10.85
`
`10.80
`
`10.75
`
`10.70
`
`1.02
`
`11.20
`11.15
`f1 (ppm)
`
`11.60
`
`11.55
`
`11.50
`
`11.45
`
`11.40
`
`11.35
`
`11.30
`
`11.25
`
`Page 14 of 34
`
`
`
`7.09
`7.10
`7.10
`7.11
`7.11
`7.11
`7.12
`7.12
`7.13
`7.14
`7.16
`7.16
`7.18
`7.23
`7.23
`7.25
`7.26
`7.26
`7.39
`7.40
`7.42
`7.43
`7.44
`7.46
`7.46
`7.46
`
`7.62
`7.62
`7.63
`7.64
`7.65
`7.66
`
`7.88
`7.89
`7.90
`7.91
`7.95
`
`8.13
`
`8.32
`8.33
`
`
`
`2111KEYS.469B
`13-142-1E
`DMSO, H-1
`NUMEGA 12-30-2021
`
`1.26
`0.46
`2.18
`
`1.96
`
`2.13
`
`1.12
`
`1.05
`
`1.00
`
`0.45
`
`1.09
`
`1.00
`
`8.8
`
`8.7
`
`8.6
`
`8.5
`
`8.4
`
`8.3
`
`8.2
`
`8.1
`
`8.0
`
`7.9
`
`7.8
`7.7
`f1 (ppm)
`
`7.6
`
`7.5
`
`7.4
`
`7.3
`
`7.2
`
`7.1
`
`7.0
`
`6.9
`
`6.8
`
`6.7
`
`Page 15 of 34
`
`
`
`4.28
`4.30
`
`4.67
`4.69
`
`
`
`2111KEYS.469B
`13-142-1E
`DMSO, H-1
`NUMEGA 12-30-2021
`
`1.15
`
`1.13
`
`6.6
`
`6.5
`
`6.4
`
`6.3
`
`6.2
`
`6.1
`
`6.0
`
`5.9
`
`5.8
`
`5.7
`
`5.6
`
`5.5
`
`5.4
`
`5.3
`5.2
`5.1
`f1 (ppm)
`
`5.0
`
`4.9
`
`4.8
`
`4.7
`
`4.6
`
`4.5
`
`4.4
`
`4.3
`
`4.2
`
`4.1
`
`4.0
`
`3.9
`
`3.8
`
`Page 16 of 34
`
`
`
`1.49
`1.50
`1.50
`1.51
`1.69
`1.70
`1.71
`1.72
`
`2.03
`
`2.30
`2.38
`2.49
`2.50
`2.50
`2.51
`2.51
`2.62
`2.63
`2.63
`2.65
`2.69
`2.73
`2.89
`
`3.33
`
`
`
`2111KEYS.469B
`13-142-1E
`DMSO, H-1
`NUMEGA 12-30-2021
`
`1.07
`
`1.08
`
`3.12
`
`3.10
`
`3.11
`
`1.05
`3.82
`1.52
`
`1.63
`
`1.76
`
`3.7
`
`3.6
`
`3.5
`
`3.4
`
`3.3
`
`3.2
`
`3.1
`
`3.0
`
`2.9
`
`2.8
`
`2.7
`
`2.6
`
`2.5
`
`2.4
`
`2.3
`
`2.2
`2.1
`f1 (ppm)
`
`2.0
`
`1.9
`
`1.8
`
`1.7
`
`1.6
`
`1.5
`
`1.4
`
`1.3
`
`1.2
`
`1.1
`
`1.0
`
`0.9
`
`0.8
`
`0.7
`
`0.6
`
`Page 17 of 34
`
`
`
` Company:
`
`NuMega
`Key Synthesis LLC
`11526 Sorrento Valley Road Ste.B2 -
`804 Primrose Lane
`San Diego, CA 92121
`Wynnewood, PA 19096
`TTermme—mmeme—me—=|Tels (858)793-6057 Fax: (858)793-2607
`ee http://www.Numegalabs.com
`610-367-3281
`Fax:
`Numegalab@numegalabs.com
`Ron Bihovsky
`Date:
`3) {2249
`Email:
`
`Address:
`
`Telephone:
`Name:
`PO#
`
`12/24/21
`rbihovsky@keysynthesis.cg™
`
`pyr LX) and FIDL_|
`
`
`
`
`Sample ID
`
`Elemental Analysis
`Theoretical %
`please continue *
`
`|TY lpmro
`
`ee
`pO
`PT
`es
`Pf
`es ee
`
`* Elemental Analysis (3 mg per run) Single:| |Duplicate:||
`
`-0.5 to 10 ppm,integration, peak picking for H-1, 0-200 ppm, peak picking for C-13.
`NMR (PDF):
`Chemical shift (H-1). TMS (0), DMSO (2.50), CDC13(7.26), or DO (4.78).
`
`*Mass: Img in ImL or 20-50 UM,positive and negative modes.Please specify MW range.
`
`our Instructions /Remarks: (Hygroscopic, Explosive, Volatile, Toxicity, Storage, EA theoretical %, etc.)
`
`(FID: please request)
`
`onfidentiality: NuMega maintains spectral information in strict confidence
`Commentfrom Analyst:
`For NuMega Use Only
`
`Z7ay Co
`
`
`
`
`
`
`
`WAST_SS=[| (ENDa=.
`
`
`
`FNor-Reutine[x=|SS)|_x97m|
`|
`
`
`
`onesx=|rT
`
`Total Charge:
`$ GY
`Analyst: Sige
`Date
`| L ~ ce 7
`
`Page 18 of 34
`
`Page 18 of 34
`
`
`
`1.48
`1.49
`1.50
`1.51
`1.69
`1.70
`1.71
`1.72
`2.03
`2.38
`2.50
`2.50
`2.50
`2.62
`2.64
`2.64
`2.65
`
`3.35
`
`4.28
`4.30
`4.66
`4.68
`
`7.08
`7.08
`7.09
`7.10
`7.10
`7.10
`7.11
`7.11
`7.12
`7.12
`7.39
`7.39
`7.40
`7.40
`7.41
`7.43
`7.44
`7.44
`7.46
`7.46
`7.46
`7.61
`7.61
`7.62
`7.63
`7.64
`7.65
`7.89
`7.89
`7.90
`7.91
`8.13
`8.31
`8.32
`11.22
`
`
`
`2200KEYS.048A
`13-134-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`1.01
`0.99
`2.97
`2.95
`1.00
`
`0.74
`
`1.01
`
`1.01
`
`0.97
`1.97
`1.05
`1.00
`0.97
`1.00
`0.95
`
`0.96
`
`12.5
`
`11.5
`
`10.5
`
`9.5
`
`8.5
`
`7.5
`
`6.5
`f1 (ppm)
`
`5.5
`
`4.5
`
`3.5
`
`2.5
`
`1.5
`
`0.5
`
`-0.5
`
`Page 19 of 34
`
`
`
`7.08
`7.08
`7.09
`7.10
`7.10
`7.10
`7.11
`7.11
`7.12
`7.12
`
`7.39
`7.39
`7.40
`7.40
`7.41
`7.43
`7.44
`7.44
`7.46
`7.46
`7.46
`7.61
`7.61
`7.62
`7.63
`7.64
`7.65
`
`7.89
`7.89
`7.90
`7.91
`
`8.13
`
`8.31
`8.32
`
`
`
`2200KEYS.048A
`13-134-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`0.97
`
`1.97
`
`1.05
`
`1.00
`
`0.97
`
`1.00
`
`0.95
`
`8.5
`
`8.4
`
`8.3
`
`8.2
`
`8.1
`
`8.0
`
`7.9
`
`7.8
`7.7
`f1 (ppm)
`
`7.6
`
`7.5
`
`7.4
`
`7.3
`
`7.2
`
`7.1
`
`7.0
`
`Page 20 of 34
`
`
`
`1.48
`1.49
`1.50
`1.51
`1.69
`1.70
`1.71
`1.72
`
`2.03
`
`2.38
`2.49
`2.50
`2.50
`2.50
`2.51
`2.62
`2.64
`2.64
`2.65
`
`3.35
`
`4.28
`4.30
`
`4.66
`4.68
`
`
`
`2200KEYS.048A
`13-134-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`1.01
`
`0.99
`
`2.97
`
`2.95
`
`1.00
`
`0.74
`
`1.01
`
`1.01
`
`5.0
`
`4.8
`
`4.6
`
`4.4
`
`4.2
`
`4.0
`
`3.8
`
`3.6
`
`3.4
`
`3.2
`3.0
`f1 (ppm)
`
`2.8
`
`2.6
`
`2.4
`
`2.2
`
`2.0
`
`1.8
`
`1.6
`
`1.4
`
`1.2
`
`Page 21 of 34
`
`
`
`17.82
`18.41
`24.42
`26.94
`34.13
`39.03
`39.20
`39.36
`39.53
`39.70
`39.87
`40.03
`
`70.83
`
`113.67
`113.84
`114.25
`115.69
`115.86
`124.75
`125.03
`125.18
`130.08
`130.14
`135.11
`135.30
`139.38
`145.02
`145.08
`148.58
`148.95
`154.45
`155.55
`156.42
`158.51
`161.06
`163.00
`168.74
`
`
`
`2200KEYS.048E
`13-134-1X
`DMSO, C-13
`NUMEGA 1-05-2022
`
`200
`
`190
`
`180
`
`170
`
`160
`
`150
`
`140
`
`130
`
`120
`
`110
`
`100
`f1 (ppm)
`
`90
`
`80
`
`70
`
`60
`
`50
`
`40
`
`30
`
`20
`
`10
`
`0
`
`Page 22 of 34
`
`
`
`124.75
`125.03
`125.18
`
`130.08
`130.14
`
`135.11
`135.30
`
`139.38
`
`145.02
`145.08
`
`148.58
`148.95
`
`154.45
`155.55
`156.42
`
`158.51
`
`161.06
`
`163.00
`
`168.74
`
`
`
`2200KEYS.048E
`13-134-1X
`DMSO, C-13
`NUMEGA 1-05-2022
`
`172
`
`170
`
`168
`
`166
`
`164
`
`162
`
`160
`
`158
`
`156
`
`154
`
`152
`
`150
`
`148
`146
`f1 (ppm)
`
`144
`
`142
`
`140
`
`138
`
`136
`
`134
`
`132
`
`130
`
`128
`
`126
`
`124
`
`122
`
`Page 23 of 34
`
`
`
`17.82
`18.41
`
`24.42
`
`26.94
`
`34.13
`39.03
`39.20
`39.36
`39.53
`39.70
`39.87
`40.03
`
`70.83
`
`113.67
`113.84
`114.25
`115.69
`115.86
`
`
`
`2200KEYS.048E
`13-134-1X
`DMSO, C-13
`NUMEGA 1-05-2022
`
`120
`
`115
`
`110
`
`105
`
`100
`
`95
`
`90
`
`85
`
`80
`
`75
`
`70
`65
`f1 (ppm)
`
`60
`
`55
`
`50
`
`45
`
`40
`
`35
`
`30
`
`25
`
`20
`
`15
`
`Page 24 of 34
`
`
`
`1.49
`1.50
`1.50
`1.51
`1.69
`1.70
`1.70
`1.71
`2.03
`2.38
`2.49
`2.50
`2.50
`2.50
`2.51
`2.63
`2.63
`
`3.33
`
`4.28
`4.30
`4.67
`4.69
`
`7.09
`7.09
`7.10
`7.10
`7.10
`7.11
`7.11
`7.11
`7.12
`7.12
`7.13
`7.39
`7.39
`7.40
`7.40
`7.41
`7.43
`7.44
`7.45
`7.46
`7.46
`7.62
`7.62
`7.64
`7.64
`7.65
`7.66
`7.88
`7.89
`7.90
`7.91
`8.13
`8.32
`8.33
`11.22
`
`
`
`2200KEYS.048B
`13-137-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`1.01
`1.01
`2.96
`2.89
`1.00
`
`1.03
`
`1.01
`
`1.00
`
`0.96
`1.91
`1.09
`0.99
`0.96
`1.00
`0.94
`
`0.97
`
`12.5
`
`11.5
`
`10.5
`
`9.5
`
`8.5
`
`7.5
`
`6.5
`f1 (ppm)
`
`5.5
`
`4.5
`
`3.5
`
`2.5
`
`1.5
`
`0.5
`
`-0.5
`
`Page 25 of 34
`
`
`
`7.09
`7.09
`7.10
`7.10
`7.10
`7.11
`7.11
`7.11
`7.12
`7.12
`7.13
`7.39
`7.39
`7.40
`7.40
`7.41
`7.43
`7.44
`7.45
`7.46
`7.46
`7.62
`7.62
`7.64
`7.64
`7.65
`7.66
`
`7.88
`7.89
`7.90
`7.91
`
`8.13
`
`8.32
`8.33
`
`
`
`2200KEYS.048B
`13-137-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`0.96
`
`1.91
`
`1.09
`
`0.99
`
`0.96
`
`1.00
`
`0.94
`
`8.5
`
`8.4
`
`8.3
`
`8.2
`
`8.1
`
`8.0
`
`7.9
`
`7.8
`
`7.7
`7.6
`f1 (ppm)
`
`7.5
`
`7.4
`
`7.3
`
`7.2
`
`7.1
`
`7.0
`
`6.9
`
`6.8
`
`Page 26 of 34
`
`
`
`1.49
`1.50
`1.50
`1.51
`1.69
`1.70
`1.70
`1.71
`
`2.03
`
`2.38
`2.49
`2.50
`2.50
`2.50
`2.51
`2.62
`2.63
`2.63
`2.64
`
`3.33
`
`4.28
`4.30
`
`4.67
`4.69
`
`
`
`2200KEYS.048B
`13-137-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`1.01
`
`1.01
`
`2.96
`
`2.89
`
`1.00
`
`1.03
`
`1.01
`
`1.00
`
`5.0
`
`4.8
`
`4.6
`
`4.4
`
`4.2
`
`4.0
`
`3.8
`
`3.6
`
`3.4
`
`3.2
`3.0
`f1 (ppm)
`
`2.8
`
`2.6
`
`2.4
`
`2.2
`
`2.0
`
`1.8
`
`1.6
`
`1.4
`
`1.2
`
`Page 27 of 34
`
`
`
`1.49
`1.50
`1.51
`1.51
`1.69
`1.70
`1.70
`1.71
`2.03
`2.38
`2.49
`2.50
`2.50
`2.50
`2.51
`2.63
`2.63
`
`3.33
`
`4.28
`4.30
`4.67
`4.69
`
`7.09
`7.09
`7.10
`7.11
`7.11
`7.12
`7.12
`7.12
`7.13
`7.39
`7.39
`7.40
`7.42
`7.43
`7.44
`7.45
`7.46
`7.46
`7.62
`7.63
`7.64
`7.64
`7.65
`7.66
`7.88
`7.89
`7.90
`7.90
`8.13
`8.32
`8.33
`11.22
`
`
`
`2200KEYS.048C
`13-143-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`1.01
`1.01
`2.95
`2.92
`1.00
`
`1.78
`
`1.01
`
`1.01
`
`0.96
`1.94
`1.05
`0.98
`0.95
`1.00
`0.93
`
`0.96
`
`12.5
`
`11.5
`
`10.5
`
`9.5
`
`8.5
`
`7.5
`
`6.5
`f1 (ppm)
`
`5.5
`
`4.5
`
`3.5
`
`2.5
`
`1.5
`
`0.5
`
`-0.5
`
`Page 28 of 34
`
`
`
`7.09
`7.09
`7.10
`7.11
`7.11
`7.12
`7.12
`7.12
`7.13
`
`7.39
`7.39
`7.40
`7.42
`7.43
`7.44
`7.45
`7.46
`7.46
`7.62
`7.63
`7.64
`7.64
`7.65
`7.66
`
`7.88
`7.89
`7.90
`7.90
`
`8.13
`
`8.32
`8.33
`
`
`
`2200KEYS.048C
`13-143-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`0.96
`
`1.94
`
`1.05
`
`0.98
`
`0.95
`
`1.00
`
`0.93
`
`8.6
`
`8.5
`
`8.4
`
`8.3
`
`8.2
`
`8.1
`
`8.0
`
`7.9
`
`7.8
`
`7.7
`f1 (ppm)
`
`7.6
`
`7.5
`
`7.4
`
`7.3
`
`7.2
`
`7.1
`
`7.0
`
`6.9
`
`6.8
`
`Page 29 of 34
`
`
`
`1.49
`1.50
`1.51
`1.51
`1.69
`1.70
`1.70
`1.71
`
`2.03
`
`2.38
`2.49
`2.50
`2.50
`2.50
`2.51
`2.62
`2.63
`2.63
`2.64
`
`3.33
`
`4.28
`4.30
`
`4.67
`4.69
`
`
`
`2200KEYS.048C
`13-143-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`1.01
`
`1.01
`
`2.95
`
`2.92
`
`1.00
`
`1.78
`
`1.01
`
`1.01
`
`4.8
`
`4.6
`
`4.4
`
`4.2
`
`4.0
`
`3.8
`
`3.6
`
`3.4
`
`3.2
`3.0
`f1 (ppm)
`
`2.8
`
`2.6
`
`2.4
`
`2.2
`
`2.0
`
`1.8
`
`1.6
`
`1.4
`
`1.2
`
`Page 30 of 34
`
`
`
`1.49
`1.50
`1.51
`1.52
`1.69
`1.70
`1.70
`1.71
`2.03
`2.38
`2.49
`2.50
`2.50
`2.50
`2.51
`2.62
`2.63
`2.63
`2.64
`3.32
`
`4.28
`4.30
`4.67
`4.69
`
`
`
`7.09
`7.09
`7.10
`7.10
`7.11
`7.11
`7.12
`7.12
`7.13
`7.13
`7.39
`7.39
`7.39
`7.40
`7.40
`7.42
`7.43
`7.44
`7.45
`7.46
`7.46
`7.62
`7.63
`7.64
`7.64
`7.65
`7.66
`7.88
`7.89
`7.90
`7.90
`8.13
`8.32
`8.33
`11.22
`
`2200KEYS.048D
`13-144-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`1.00
`1.00
`2.96
`2.91
`1.01
`
`2.03
`
`1.00
`
`1.01
`
`0.96
`1.85
`1.15
`0.99
`0.95
`1.00
`0.93
`
`0.94
`
`12.0
`
`11.5
`
`11.0
`
`10.5
`
`10.0
`
`9.5
`
`9.0
`
`8.5
`
`8.0
`
`7.5
`
`7.0
`
`6.5
`
`6.0
`5.5
`f1 (ppm)
`
`5.0
`
`4.5
`
`4.0
`
`3.5
`
`3.0
`
`2.5
`
`2.0
`
`1.5
`
`1.0
`
`0.5
`
`0.0
`
`-0.5
`
`Page 31 of 34
`
`
`
`7.09
`7.09
`7.10
`7.10
`7.11
`7.11
`7.12
`7.12
`7.13
`7.13
`7.39
`7.39
`7.39
`7.40
`7.40
`7.42
`7.43
`7.44
`7.45
`7.46
`7.46
`7.62
`7.63
`7.64
`7.64
`7.65
`7.66
`
`7.88
`7.89
`7.90
`7.90
`
`8.13
`
`8.32
`8.33
`
`
`
`2200KEYS.048D
`13-144-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`0.96
`
`1.85
`
`1.15
`
`0.99
`
`0.95
`
`1.00
`
`0.93
`
`8.6
`
`8.5
`
`8.4
`
`8.3
`
`8.2
`
`8.1
`
`8.0
`
`7.9
`
`7.8
`
`7.7
`f1 (ppm)
`
`7.6
`
`7.5
`
`7.4
`
`7.3
`
`7.2
`
`7.1
`
`7.0
`
`6.9
`
`Page 32 of 34
`
`
`
`1.49
`1.50
`1.51
`1.52
`1.69
`1.70
`1.70
`1.71
`
`2.03
`
`2.38
`2.49
`2.50
`2.50
`2.50
`2.51
`2.62
`2.63
`2.63
`2.64
`
`3.32
`
`4.28
`4.30
`
`4.67
`4.69
`
`
`
`2200KEYS.048D
`13-144-1X
`DMSO, H-1
`NUMEGA 1-05-2022
`
`1.00
`
`1.00
`
`2.96
`
`2.91
`
`1.01
`
`2.03
`
`1.00
`
`1.01
`
`5.0
`
`4.8
`
`4.6
`
`4.4
`
`4.2
`
`4.0
`
`3.8
`
`3.6
`
`3.4
`
`3.2
`3.0
`f1 (ppm)
`
`2.8
`
`2.6
`
`2.4
`
`2.2
`
`2.0
`
`1.8
`
`1.6
`
`1.4
`
`1.2
`
`Page 33 of 34
`
`
`
`Telephone:
`
`
`
`
`Elemental Analysis
`Theoretical %
`please continue *
`
`and rip|_|
`
`
`
`
`
`Company: NuMegaaAKey Synthesis LLC
`
`Address: B04PrimroseLane 11526 Sorrento Valley Road Ste.B2 »
`Wynnewood, PA 19096
`San Diego, CA 92121
`a Tel: (858)793-6057 Fax: (858)793-2607
`eee http://www.Numegalabs.com
`610-367-3281
`Fax:
`Numegalab@numegalabs.com
`Ron Bihovsky
`Date:
`WT, 3 / 20
`2206/03
`Email:
`rbihovsky@keysynthesis.qgm
`PO#
`
`
`
`
`
`
` Name:
` Sample ID * Elemental Analysis (3 mg perrun) Single:|
`
`
`|Duplicate:
`
`NMR (PDF):
`-0.5 to 10 ppm,integration, peak picking for H-1, 0-200 ppm,peak picking for C-13, (FID: please request)
`Chemical shift (H-1). TMS (0), DMSO (2.50), CDC13(7.26), or D2O (4.78),
`Mass: 1mgin ImL or 20-50 UM,positive and negative modes. Please specify MW range.
`our Instructions /Remarks: (Hygroscopic, Explosive, Volatile, Toxicity, Storage, EA theoretical %, etc.)
`‘Fo MR
`ON 1Z-SZ4-(K
`
`Commentfrom Analyst:
`
`p
`
`pectral information in strict confidence
`For NuMega Use Only
`
`
`
`
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` CHN (S/D)|__x $27/42 =
`[NowRouine[x=|SO
`
`[RouineNMR[UxS40=|
`S (S/D)
`___ x $27/42=
`
`
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`
`
`
`Analyst:
`Page 34 of 34
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`Total Charge:
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`$ SY
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`Page 34 of 34
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