`Sent:
`To:
`Cc:
`
`Subject:
`
`Lessler, Jay <jlessler@BlankRome.com>
`Wednesday, December 09, 2020 10:57 AM
`Wexler, Bruce M.
`Rupert, Melanie R.; Park, Young J.; Donna_Meuth@eisai.com;
`alex_chen@crystalpharmatech.com; yan_li@crystalpharmatech.com;
`brian.lipton@gyma.com
`[EXT] RE: [EXTERNAL] Lemborexant
`
`Dear(cid:3)Bruce,(cid:3)
`(cid:3)(cid:3)
`Thank(cid:3)you(cid:3)for(cid:3)your(cid:3)email.(cid:3)
`(cid:3)(cid:3)
`Crystal(cid:3)Pharmaceutical(cid:3)has(cid:3)not(cid:3)repeated(cid:3)the(cid:3)synthesis(cid:3)of(cid:3)compound(cid:3)(14)(cid:3)at(cid:3)col.(cid:3)46,(cid:3)line(cid:3)48,(cid:3)to(cid:3)col.(cid:3)47,(cid:3)line(cid:3)20,(cid:3)or(cid:3)at(cid:3)col.(cid:3)
`49,(cid:3)lines(cid:3)1(cid:882)56,(cid:3)of(cid:3)the(cid:3)‘109(cid:3)Patent.(cid:3)(cid:3)However,(cid:3)based(cid:3)on(cid:3)Crystal(cid:3)Pharmaceutical’s(cid:3)crystallization(cid:3)experience(cid:3)with(cid:3)over(cid:3)1,000(cid:3)
`compounds(cid:3)and(cid:3)its(cid:3)expertise(cid:3)in(cid:3)understanding(cid:3)the(cid:3)unpredictable(cid:3)nature(cid:3)of(cid:3)crystal(cid:3)nucleation,(cid:3)it(cid:3)is(cid:3)Crystal(cid:3)
`Pharmaceutical’s(cid:3)strong(cid:3)belief(cid:3)that(cid:3)the(cid:3)procedures(cid:3)disclosed(cid:3)at(cid:3)col.(cid:3)46,(cid:3)line(cid:3)48,(cid:3)to(cid:3)col.(cid:3)47,(cid:3)line(cid:3)20,(cid:3)and(cid:3)at(cid:3)col.(cid:3)49,(cid:3)lines(cid:3)1(cid:882)
`56,(cid:3)of(cid:3)the(cid:3)‘109(cid:3)Patent(cid:3)will(cid:3)not(cid:3)necessarily(cid:3)and(cid:3)inevitably(cid:3)result(cid:3)in(cid:3)a(cid:3)crystalline(cid:3)product(cid:3)as(cid:3)claimed(cid:3)in(cid:3)the(cid:3)‘779(cid:3)
`REDACTED
`Patent.(cid:3)
`(cid:3)(cid:3)
`
`(cid:3)
`
`REDACTED
`
`(cid:3)(cid:3)
`We(cid:3)look(cid:3)forward(cid:3)to(cid:3)hearing(cid:3)from(cid:3)you.(cid:3)
`(cid:3)(cid:3)
`Kind(cid:3)regards,(cid:3)
`(cid:3)(cid:3)
`Jay(cid:3)
`
`(cid:3)J
`
`ay(cid:3)P.(cid:3)Lessler(cid:3)|(cid:3)BLANKROME(cid:3)(cid:3)
`1271(cid:3)Avenue(cid:3)of(cid:3)the(cid:3)Americas(cid:3)|(cid:3)New(cid:3)York,(cid:3)NY(cid:3)10020(cid:3)
`O:(cid:3)212.885.5176(cid:3)|(cid:3)F:(cid:3)917.332.3773(cid:3)|(cid:3)jlessler@blankrome.com(cid:3)
`REDACTED
`
`Page 1 of 1
`
`EISAI EXHIBIT 1041
`Eisai v. Crystal Pharm.
`PGR2021-00047
`
`
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