11/2/2020
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`1 in 4 Americans Develop Insomnia Each Year – PR News
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`Home News Releases 1 in 4 Americans Develop Insomnia Each Year› ›
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`News Release
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`1 in 4 Americans Develop Insomnia Each Year
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`Penn study finds about 75 percent of those with insomnia recover normal sleep
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`June 05, 2018
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`BALTIMORE – About 25 percent of Americans
`experience acute insomnia each year, but about
`75 percent of these individuals recover without
`developing persistent poor sleep or chronic
`insomnia, according to a study from researchers
`at the Perelman School of Medicine at the
`University of Pennsylvania which will be
`presented Monday at SLEEP 2018, the 32nd
`Annual Meeting of the Associated Professional
`Sleep Societies LLC (APSS).
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`The new study offers the latest data on the
`prevalence of acute insomnia, which is
`characterized by difficulty falling asleep or staying
`asleep for as little as three nights per week for at least two consecutive weeks up to three months. Insomnia becomes
`chronic when it occurs at least three nights a week for more than three months.
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`“Whether caused by stress, illness, medications, or other factors, poor sleep is very common,” said senior author
`Michael Perlis, PhD, an associate professor of Psychiatry and director of the Behavioral Sleep Medicine program.
`“These findings reveal new insights about the paths that acute insomnia takes and can inform interventions that target
`poor sleep and help people recover sustained sufficient sleep.”
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`The findings, (#0359) will be presented at SLEEP 2018, the 32nd Annual Meeting of the Associated Professional Sleep
`Societies LLC (APSS) in Baltimore.
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`Although some studies have offered the prevalence of insomnia symptoms in large populations, to date this is the first
`study to offer data on transitions of good sleepers (GS) – defined as those needing fewer than 15 minutes to fall asleep
`and/or who spend fewer than 15 minutes awake during the night on five or more nights per week. The study specifically
`determines how GS transition to acute insomnia (AI), to persistent poor sleep (PPS) – i.e., recurring bouts of AI without
`sustained recovery or turning to chronic insomnia (CI), to chronic insomnia, and how many of those affected by AI
`recover.
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`https://www.pennmedicine.org/news/news-releases/2018/june/1-in-4-americans-develop-insomnia-each-year
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`EISAI EXHIBIT 1025
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`1 in 4 Americans Develop Insomnia Each Year – PR News
`11/2/2020
`A total of 1,435 adults were recruited nationwide and tracked for one year during 2015-2017. They were verified as
`good sleepers over the first three months of the study and assessed on a daily, weekly and monthly basis for one full
`year. The subjects kept a daily sleep diary for the duration of the study, allowing for a uniquely detailed level of insight
`into how sleep varies from day to day. Also, regular assessments were made regarding participants’ daytime function,
`stress and life events, and medical and mental health.
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`Among the 25 percent experiencing acute insomnia, about 75 percent of subjects recovered good sleep within 12
`months, while 21 percent remained poor sleepers with recurring bouts of AI, and about 6 percent developed chronic
`insomnia. No significant differences were observed along racial, ethnic, or gender lines, or among people of varying
`incomes or BMI.
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`The new data provides researchers with how many people experience AI each year, as well as how those cases
`progress, laying the groundwork for additional research now underway to assess what factors predict recovery
`(resilience) and non-recovery (persistent poor sleep or the new onset of chronic insomnia).
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`The findings will be presented during the poster session on Tuesday, June 5, from 3:15-3:30 pm in room 337 at the
`Baltimore Convention Center.
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`Previous research from the Perlis team has shown that suicides are more likely to occur after midnight than during the
`daytime or evening and another study showing that more sleep reduces suicide risk in those with insomnia.
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`This work was funded by the National Institutes of Health (R01AG041783) and by the Economic and Social Research
`Council (RES-061-25-0120-A).
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`In addition to Perlis, additional authors include lead author Amy Gencarelli, as well as Waliuddin Khader, Knashawn
`H. Morales, Ivan Vargas, and Jaqueline Kloss, from Penn, as well as Michael Grandner from the University of
`Arizona, and Jason Ellis from Northumbria University.
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`TOPIC:
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` Sleep Medicine
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`Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education,
`biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of
`Medicine at the University of Pennsylvania (founded in 1765 as the nation’s first medical school) and the University of
`Pennsylvania Health System, which together form a $8.6 billion enterprise.
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`The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years,
`according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the
`nation's top recipients of funding from the National Institutes of Health, with $494 million awarded in the 2019 fiscal year.
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`The University of Pennsylvania Health System’s patient care facilities include: the Hospital of the University of Pennsylvania and
`Penn Presbyterian Medical Center—which are recognized as one of the nation’s top “Honor Roll” hospitals by U.S. News &
`World Report—Chester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania
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`https://www.pennmedicine.org/news/news-releases/2018/june/1-in-4-americans-develop-insomnia-each-year
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`1 in 4 Americans Develop Insomnia Each Year – PR News
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`Hospital, the nation’s first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners,
`Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.
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`Penn Medicine is powered by a talented and dedicated workforce of more than 43,900 people. The organization also has
`alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more
`options for patients no matter where they live.
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`Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In
`fiscal year 2019, Penn Medicine provided more than $583 million to benefit our community.
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`https://www.pennmedicine.org/news/news-releases/2018/june/1-in-4-americans-develop-insomnia-each-year
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