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`IRENE GEORGAKOUDI
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`Irene Georgakoudi, PhD
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`36 Mayflower Road
`Winchester, MA 01890
`+1-617-716-9001
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`Tufts University
`Biomedical Engineering Dept.
`Science and Technology Center, Rm. 137
`Medford, MA 02155
`
`P: +1-617-627-4353
`F: +1-617-627-3231
`Emai;: Irene.georgakoudi@tufts.edu
`http://ase.tufts.edu/biomedical/faculty-staff/georgakoudi.asp
`
`EDUCATION
`1989-1993 Dartmouth College, Hanover, NH
`B.A. in Physics with high honors; Magna cum Laude; Presidential Scholar
`1993-1998 University of Rochester, School of Medicine and Dentistry, Rochester, NY
`Ph.D. in Biophysics, 1999; Area of Specialization: Photodynamic Therapy of Cancer
`Research advisor: Dr. Thomas H. Foster
`M.Sc. in Biophysics, 1996
`
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`1999-2002 Massachusetts Institute of Technology, Laser Biomedical Research Center, Cambridge, MA
`NIH Training Fellowship; Area of Specialization: Biomedical Spectroscopy/Cancer diagnostics
`Research advisor: Dr. Michael S. Feld
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`ACADEMIC APPOINTMENTS
`
`02/2002-08/2002 Research Scientist Massachusetts Institute of Technology
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`01/2003-08/2004 Assistant in Physics Massachusetts General Hospital
`
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`01/2003-08/
`2004
`Instructor
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`Harvard Medical School
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`09/2004-08/2008 Assistant Professor Tufts University, Biomedical Engineering Dept
`09/2008-8/2017 Associate Professor Tufts University, Biomedical Engineering Dept
`09/2010-06/2011 Visiting Scientist
`École Polytechnique, Laboratoire d’Optique et
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`
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`Biosciences
`9/2017-Present Professor
`
`Tufts University, Biomedical Engineering Dept
`4/2018-Present Professor
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`Tufts University, Program in Cell, Molecular and
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`Developmental Biology
`OTHER WORK EXPERIENCE
`09/2002-12/2002 Manager, Optical Modeling Argose, Inc
`AWARDS AND HONORS
`1993
`Francis W. Sears Prize, Department of Physics and Astronomy, Dartmouth College, Hanover,
`NH
`Leonidas Lantzounis Research Grant, Hellenic Medical Society of New York
`Graduate Alumni Fellowship, School of Medicine and Dentistry, University of Rochester,
`Rochester, NY
`Graduate Student Society Leadership Award, University of Rochester, Rochester, NY
`1997
`Agnes M. and George Messersmith Fellowship, University of Rochester, Rochester, NY
`1997
`William F. Neuman Award, Biophysics Department, University of Rochester, Rochester, NY
`1998
`1999-2002
`National Research Service Award, U.S. National Institutes of Health
`2004
`Claflin Distinguished Scholar Award, Massachusetts General Hospital, Harvard Medical School.
`2005
`Inaugural Sturge Price awarded for “pioneering contributions to spectral diagnosis of biological
`materials using optical spectroscopic methodology.”
`2006-2011 NSF Career Award: Non-invasive modalities for optical imaging of cell-matrix interactions in
`engineered tissues
`Attendee of the US Frontiers in Engineering Symposium organized by the National Academy of
`Engineering
`External PhD thesis examiner, Lund University, Lund Sweeden
`1
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`Cambridge, MA
`Boston, MA
`Boston, MA
`Medford, MA
`Medford, MA
`Palaiseau, France
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`Medford, MA
`Boston, MA
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`
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`Waltham MA
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`1994
`1996
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`2006
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`2007
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`Irene Georgakoudi, PhD
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`Fellow, American Institute of Medical and Biological Engineering
`Fellow, Optical Society of America
`Senior Member, SPIE, The International Society for Optics and Photonics
`Fellow, SPIE, The International Society for Optics and Photonics
`
`
`2015
`2016
`2016
`2020
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`2011-2017
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`2013/2015
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`2018
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`2017-Present
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`2004-Present
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`COMMITTEE AND PROFESSIONAL SERVICE ASSIGNMENTS
`Scientific journal review and editor responsibilities
`2009/2011
`Guest editor, Applied Optics special issues. Responsibilities included soliciting
`manuscript submissions and overseeing peer review process, i.e. identifying reviewers
`and making publication decisions
`Associate editor, PLoS ONE. Oversee the peer review process of assigned manuscripts
`focused on biomedical optics topics, including identifying and soliciting peer reviewers,
`coordinating revisions and re-reviews, and making final publication decisions.
`Guest editor, Biomedical Optics Express. Responsibilities included soliciting manuscript
`submissions and overseeing peer review process, i.e. identifying reviewers and making
`publication decisions
`Editorial board, IEEE Journal of Selected Topics in Quantum Electronics, Special Issue
`on Biophotonics. Solicit and review manuscripts for the issue.
`Associate editor, Optica (Impact factor: 11.1). Assess impact of submitted manuscripts
`and fit for Optica. Oversee review process if manuscript is selected for peer-review.
`Reviewer for Nature, Nature Metabolism, Nature Medicine, Nature Protocols, Nature
`Biomedical Engineering, Cell Reports, Cancer Research, Biophotonics Journal, Molecular
`Cancer Research, Scientific Reports, PLoS ONE, Journal of Biomedical Optics, Applied
`Optics, Optics Letters, Optics Express, Photochemistry and Photobiology, Lasers in
`Surgery and Medicine, Journal of Microscopy, Biomedical Optics Express
`
`
`Professional Leadership
`2007
`Vice-Chair, Member and Education Services Council, Optical Society of America
`2008-2009 Chair, Member and Education Services Council, Optical Society of America
`2008-2009 Board of Directors, Optical Society of America
`2011
`Program co-chair, European Conference on Biomedical Optics, Munich, Germany
`2013
`General co-chair, European Conference on Biomedical Optics, Munich, Germany
`2013
`Committee member, Michael S. Feld Biophotonics Award (Optical Society of America)
`2014
`Committee chair, Michael S. Feld Biophotonics Award (Optical Society of America)
`2015
`Program co-chair, Optical Molecular Probes, Imaging and Drug Delivery meeting, Vancouver,
`Canada
`General chair, Optics in Life Sciences Congress, San Diego, CA
`Chair, Imaging subcommittee fellow application assessment, American Institute of Biological and
`Medical Engineering
`Co-chair, Imaging, Manipulation, and Analysis of Biomolecules Track, SPIE Photonics West, San
`Francisco CA
`
`2017
`2018
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`2021
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`Scientific Advisory Boards
`2018-Present
`Shriners Hospital for Children, Boston, MA
`2018-Present
`P41 Center for Biomedical OCT Research, Massachusetts General Hospital, Boston, MA
`2019-Present
`Scientific Council, Biomedical Engineering Institute, École Polytechnique, France
`
`Institutional and Foundation grant review panels
`2018
`MIT/Dana Farber Cancer Institute Bridge Project application review
`2019
`Novel applications and techniques for in vivo optical imaging and spectroscopy, Tyndall National
`Institute, Ireland (5 year program assessment requested by Science Foundation Ireland)
`2019-2020 Biomedical Engineering Seed Grant program, Fondation Bettencourt Schueller/École
`Polytechnique/ École Polytechnique Foundation
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`Irene Georgakoudi, PhD
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`NIH grant review panels
`2018
`NIH Medical Imaging Study Section (June panel)
`2020
`NIH Emerging Imaging Technologies and Applications Study Section (March 2020)
`2020
`NIH Imaging Technology Development Study Section (June 2020)
`2021
`NIH Innovative Molecular and Cellular Analysis Technologies (Feb 2021)
`
`Conferences
`June 2003 Program Committee, Medical and Biological Applications, CLEO/QELS Conference, Baltimore,
`MD
`June 2003 Program Committee, SPIE European Conferences on Biomedical Optics, Munich, Germany
`Oct 2003 Chair, Spectroscopy and Imaging for Disease Diagnosis session, Annual Optical Society of
`America meeting, Tucson, AZ
`April 2004 Program Committee, Optical Society of America meeting on Biomedical Optics, Miami Beach,
`FL; Session Chair: Novel Spectroscopic methods
`July 2005 Program Committee and Session chair, Advances in Optics for Biotechnology, Medicine and
`Surgery, Engineering Conferences International, Copper Mountain, CO
`Mar 2006 Program committee, Session Chair (Microscopy), Optical Society of America meeting on
`Biomedical Optics, Ft. Lauderdale, FL
`May 2006 Program committee, Conference on Lasers and Electro-Optics Quantum Electronics and Laser
`Science Conference, Long Beach, CA
`July 2006 Session organizer (New Technologies), Gordon conference on Lasers in Medicine and Biology,
`Plymouth, NH
`Oct. 2006 Program committee and session chair (Spectroscopies and contrast agents for disease
`diagnostics), Annual Meeting of the Optical Society of America, Rochester, NY
`May 2007 Program committee, Conference on Lasers and Electro-Optics Quantum Electronics and Laser
`Science Conference, Baltimore, MD
`Mar 2008 Program Chair and Session Chair; Biomedical Topical Meeting of the Optical Society of America,
`Spectroscopy Track, St. Petersburg, FL
`May 2008 Program committee, Conference on Lasers and Electro-Optics Quantum Electronics and Laser
`Science Conference, Baltimore, MD
`June 2009 Program co-chair (Spectroscopy and Imaging Track) and Session chair; European conference
`on biomedical optics; Munich, Germany
`July 2009 Program committee; Engineering Foundation conference on Advances In Optics For
`Biotechnology, Medicine And Surgery, Burlington, VT
`April 2010 Program co-chair (Advanced Microscopy Techniques) session chair; OSA Biomedical meeting,
`Miami, FL
`June 2011 Program Committee and Session chair, Engineering Foundation conference on Advances In
`Optics For Biotechnology, Medicine And Surgery, Naples, FL
`May 2012 Session chair, OSA Biomedical meeting, Miami, FL
`Oct 2012 Session chair, BMES Annual meeting, Atlanta, GA
`April 2012 Program committee, Optical Molecular Probes, Imaging and Drug Delivery, Optical Society of
`America Photonics Congress, Hawaii, April 2013
`June 2013 Program committee, Novel Microscopy Techniques, European Conference on Biomedical Optics,
`Munich Germany
`Oct 2016 Program committee, Frontiers in Optics 2016, Rochester, NY
`May 2018 Program committee, CLEO, Biomedical Imaging, San Jose, CA
`May 2019 Program committee, CLEO, Biomedical Imaging, San Jose, CA
`June 2019 Program committee, Novel Microscopy Techniques, European Conference on Biomedical Optics,
`Munich Germany
`Feb 2020 Program committee, Multiscale Imaging and Spectroscopy, SPIE Photonics West, San
`Francisco, CA
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`Irene Georgakoudi, PhD
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`Feb 2021 Co-chair, Imaging, Manipulation, and Analysis of Biomolecules; Program committee, Multiscale
`Imaging and Spectroscopy, SPIE Photonics West, San Francisco CA
`June 2021 Program committee, Novel Microscopy Techniques, European Conference on Biomedical
`Optics, Munich Germany
`Feb 2022 Program committee, Multiscale Imaging and Spectroscopy, SPIE Photonics West, San Francisco
`CA
`Apr 2022 Program committee, Biophotonics Congress: Microscopy, histopathology and analytics, Fort
`Lauderdale, FL
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`INVITED PRESENTATIONS
`June 2000 Fluorectification: Inverting tissue spectra to extract diagnostic information-A Socratic dialogue.
`Presented with Michael S. Feld at the Gordon Conference in Lasers in Medicine and Biology,
`New London, CT
`July 2000 The multiple roles of reflectance spectroscopy in disease diagnosis. International Photobiology
`Congress, San Francisco, CA
`Jan 2001 The Color of Cancer. Thayer School of Engineering, Dartmouth College, Hanover, NH
`Mar 2001 Spectroscopy for Detection of Cancer. March Meeting 2001 of the American Physical Society,
`Pake Prize Session: Spectroscopy and Structure of Disease, Seattle, WA
`May 2001 Detecting Intraepithelial Neoplasia Using Tri-Modal Spectroscopy. Lester Wolfe Workshop in
`Laser Biomedicine organized by the Wellman Photomedicine Laboratories, Harvard Medical
`School and the MIT Spectroscopy Laboratory, Boston, MA
`June 2001 Tri-Modal Spectroscopy as a tool for detecting cervical squamous intraepithelial lesions in vivo.
`European Conferences on Biomedical Optics, Munich, Germany
`June 2001 The Color of Cancer. Institute of Electronic Structure and Laser, Foundation for Research and
`Technology-Hellas, Heraklion, Greece
`Oct 2001 Characterization of Tissue Biochemistry and Morphology Using Spectroscopy. Beckman Laser
`Institute, University of California at Irvine, Irvine, CA
`Feb 2002 The Color of Cancer. Invited seminar, Department of Physics, Clemson University, Clemson, SC
`Apr 2002 The Color of Cancer: Characterization of tissue morphology and biochemistry using
`spectroscopy. Invited seminar, Biomedical Engineering, University of Rochester, Rochester, NY
`May 2002 The Color of Cancer: Characterization of tissue morphology and biochemistry using
`spectroscopy. Invited seminar, Biomedical Engineering Dept, Duke University, Durham, NC
`Oct 2003 Quantitative Characterization of Biological Tissue Using Optical Spectroscopy. Annual Meeting
`of the Optical Society of America, Tuscon, AZ.
`Feb 2004 Optical methods for the study of primary and metastatic tumors. Invited seminar, Department of
`Biomedical Engineering, Tufts University, Medford, MA
`Oct 2004 The Color of Cancer: Looking at Biological Tissues Using Spectroscopy. Invited seminar,
`Physics Department, Tufts University, Medford, MA
`May 2005 Instrinsic Fluorescence Changes Associated With Apoptosis of Human Epithelial Keratinocytes.
`Invited presentation, International Conference on Cervical Cancer, Houston, TX
`Aug 2005 The Color of Cancer. Invited presentation, 15th International Conference on Dynamical
`Processes in Excited States and Solids, Shanghai, China
`In vivo cytometry. Invited presentation, Annual Clinical Cytometry Society Meeting, Savannah,
`GA
`Mar 2005 In vivo flow cytometry. Invited presentation delivered at the Brain Trust Meeting: Prostate Cancer
`Imaging, organized by the AdMeTech Foundation and sponsored by the Prostate Cancer
`Foundation, Bethesda, MD
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`Oct 2005
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`Oct 2006
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`Irene Georgakoudi, PhD
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`June 2006 Development of novel biomarkers based on optical tissue spectroscopy and imaging of
`endogenous signals. Invited presentation, SPIE Photonics North meeting, Quebec City, Canada
`Imaging of intrinsic optical stem cell changes in engineered tissues. Invited presentation, Annual
`Meeting of the Optical Society of America, Rochester, NY.
`Dec 2006 Interactive,
`freshman class on Lasers. Learning without
`lego-based activities
`for
`Barriers/Technology Without Borders Symposium organized by the MIT-Microsoft iCampus
`Connection, Cambridge MA
`Dec 2006 Optical Diagnostics for Diseased and Engineered Tissues. Invited seminar, Center for
`Engineering in Medicine. Boston MA
`Jan 2007 Optical Methods in Tissue Engineering. Invited talk, Hot Topics Session. SPIE Photonics West
`meeting, San Jose CA
`Apr 2007 Optical Diagnostics for Engineered Tissues. Invited seminar, Biophotonics Laboratory,
`Biomedical Engineering Department, Boston University, Boston MA
`May 2007 Shedding light on engineered tissues. Invited seminar, Department of Physics, Lund Institute of
`Technology, Lund Sweden
`June 2007 Biomaterial characterization through two-photon fluorescence spectroscopic imaging. Invited
`presentation, Advances in Optics for Biotechnology, Medicine and Surgery organized by
`Engineering Conferences International. Naples, FL
`June 2007 Characterization of linear and non-linear optical properties of biomaterials in engineered tissues.
`International Conference on Dynamical Processes in Excited States of Solids. Segovia, Spain
`Jan 2009 Light scattering spectroscopy for tissue engineering applications. Invited presentation, SPIE
`Photonics West meeting, San Jose, CA
`Mar 2009 Optical spectroscopy and imaging for tissue engineering applications. Invited Seminar, Pakistan
`Institute of Technology, Islamabad, Pakistan
`Mar 2009 Optical diagnostics for diseased and engineered tissues. Invited presentation, Pakistan Institute
`of Engineered and Applied Science Biophotonics Symposium, Islamabad, Pakistan
`Mar 2009 Optical diagnostics for early cancer. Invited talk, Pakistan National Academy of Sciences,
`Islamabad, Pakistan
`June 2009 Quantitative biochemical and morphological biomarkers of pre-cancers extracted from
`tissues. School of Advanced Optical
`endogenous
`two-photon
`images of engineered
`Technologies workshop on Advanced Optical Methods for Assessment and Monitoring of Clinical
`Therapy and Monitoring, Erlangen, Germany
`July 2009 Quantitative multi-parametric two-photon imaging of tissues. Invited presentation, IEEE
`International Symposium on Biomedical Imaging, Boston, MA
`July 2009 Series of four lectures on Optical Tissue Imaging, 34th International Nathiagali Summer College
`Workshop, Islamabad, Pakistan
`Intrinsic two photon excited autofluorescence-based biomarkers of stem cell differentiation. Inter-
`Institute workshop on optical diagnostic and biophotonic methods from bench to bedside,
`Bethesda, MD
`Apr 2010 Endogenous optical biomarkers associated with stem cell differentiation. Invited presentation at
`the Northeast Bioengineering Conference, New York City, NY
`Invited Seminar, École
`Sept 2010 Optical Diagnostics
`for Diseased and Engineered Tissues.
`Polytechnique, Laboratory for Optics and Biosciences, Palaiseau, France.
`Mar 2011 Optical Diagnostics for Diseased and Engineered Tissues. Invited Seminar, ICFO-The Institute
`of Photonic Sciences, Barcelona, Spain
`May2011 Non-invasive, optical monitoring and characterization of biochemical changes during stem cell
`differentiation. Information Photonics, Ottawa, Canada
`Jun 2011 Quantitative tissue diagnostics based on non-linear optical imaging of endogenous contrast.
`Invited presentation, Physics and Biological Systems conference, Orsay, France
`
`Oct 2009
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`Irene Georgakoudi, PhD
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`Jul 2011 Dynamic monitoring of biochemical changes in 3D engineered tissues using non-linear
`microscopy, BioMethods conference, Boston, MA
`Oct 2011 Non-linear imaging for tissue engineering and disease diagnostic applications. Invited
`presentation, Symposium on New Imaging Technologies in Health and Disease, Biomedical
`Research Foundation, Academy of Athens, Athens, Greece
`Dec 2011 Dynamic monitoring of engineered tissue development using non-linear spectroscopic imaging.
`Invited seminar, Modern Optics and Spectroscopy Seminar series, MIT, Cambridge, MA
`Jan 2012 Optical diagnostics for diseased and engineered tissues. Invited Seminar, Department of
`Anatomy and Cell Biology, Tufts University School of Medicine, Boston, MA
`Jan 2012 Light scattering based monitoring of leukemic cells in flowing in vitro blood samples. Invited
`presentation, SPIE Photonics West, San Fransisco, CA
`Mar 2012 Optical diagnostics for diseased and engineered tissues. Invited Seminar, Biomedical
`Engineering Department, Texas A&M University, College Station, TX.
`April 2012 Optical diagnostics for diseased and engineered tissues. Invited Seminar, Biomedical
`Engineering Department, Purdue University, Lafayette, IN.
`May 2012 Optical diagnostics for diseased and engineered tissues. Invited seminar. Boston chapter of the
`IEEE Society.
`July 2012 Non-linear endogenous optical biomarkers for tissue engineering applications. Invited
`Presentation, Gordon Conference on Lasers in Medicine and Biology, Plymouth, NH
`Sept 2012 Development of a minimally invasive biomarker for breast cancer development and metastasis.
`CTSI Pilot Studies symposium. Boston, MA.
`April 2013 Down to a Science, Greenways weekend, Dartmouth College, Hanover, NH
`April 2013 Potential impact of optical imaging in the development of in vitro tissue models of infectious
`diseases. NIH workshop on In vitro Models of Infectious Diseases, Bethesda, MD
`Aug 2013 Assessing mitochondrial organization and function in 3D tissues using two photon excited
`fluorescence. Frontiers and Challenges in Laser-Based Microscopy, Telluride CO
`Oct. 2013 Quantitative, functional biomarkers of stem cell differentiation in 3D using multi-modal non-linear
`imaging of endogenous contrast. Frontiers in Optics / Laser Science, Orlando, FL.
`Nov 2013 Noninvasive assessment of cellular metabolic and biosynthetic function using 2PEF. ARC
`Seminar Series on Neuropeptides in Health and Disease. Beth Israel Deaconess Medical
`Center, Boston MA.
`Jan 2014 Optical metabolic biomarkers of stem cell differentiation, The Wyss Institute for Bio-inspired
`Engineering, Cambridge, MA
`Oct 2014 Non-linear optical imaging to assess metabolism in the good, the bad, and the ugly. Boston
`Photonics Society, MIT Lincoln Labs, Lexington MA
`Oct 2014 Label free assessment of mitochondrial organization in three-dimensional tissues, Frontier in
`Optics Annual meeting, Tuscon, AZ
`Dec 2014 Assessment of tissue structure and function via spectral optical imaging, Innovations in Wound
`Healing, Hawks Cay Florida Keys, FL
`Aug 2014 Endogenous two-photon excited fluorescence biomarkers of adipose tissue type and function:
`The different shades of fat. Frontiers and Challenges in Laser-Based Microscopy, Telluride CO
`Sep 2015 Mitochondrial organization of 3D tissues as a diagnostic cancer biomarker. SPIE/NIH workshop,
`Biophotonics from Bench to Bedside, Bethesda MD
`Oct 2015 Label-free high resolution imaging of structure and function of the good, the bad and the ugly.
`BME Dept. seminar, Tulane University, New Orleans, LO
`Oct 2015 Label free imaging of cell metabolism in 3D tissues. Wellman Center for Photomedicine,
`Massachusetts General Hospital, Harvard Medical School. 40th Anniversary Celebration. Boston,
`MA
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`Irene Georgakoudi, PhD
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`Nov 2015 Label-free high resolution imaging of structure and function of three dimensional tissues. Unilever
`Corporation, Trumbull, CT
`May 2016 Optical monitoring of engineered tissue development and function, Lester Wolfe Workshop in
`Biomedicine, Boston, MA
`Oct 2016 Unraveling tissue metabolism using endogenous, two-photon imaging: mechanisms and
`diagnostic biomarkers, Frontiers in Optics, Rochester NY
`May 2017 Frontiers of in vivo clinical microscopic imaging: New tools for solving the pain puzzle, Plenary
`speaker, VII European Multidisciplinary Pain Meeting, Menorca, Spain
`Aug 2017 Label-free metabolic imaging, Frontiers and Challenges in Laser-Based Biological Microscopy,
`Telluride, CO
`Sept 2017 Optical tissue diagnostics based on label-free, functional biomarkers, Plenary Speaker, 14th
`International Conference on Photonics and Imaging in Biology and Medicine, Suzhou, China
`Oct 2017 Label-free, morpho-functional high resolution tissue imaging for cancer diagnosis, Department
`of Cell, Molecular and Developmental Biology, Tufts University School of Medicine
`Nov 2017 Label-free, morpho-functional high resolution tissue imaging for cancer diagnosis, Biomedical
`Engineering Department, Northwestern University
`Jan 2018 Optical, label-free, morpho-functional metabolic imaging, SPIE Photonics West BIOS, Hot
`Topics Plenary Session, San Francisco, CA
`Feb 2018 Label-free multi-photon imaging to assess tissue function, Neuroscience Department Seminar,
`Sackler School of Graduate Biomedical Sciences, Tufts University, Boston MA
`Apr 2018 Unraveling the origins of endogenous optical metabolic changes using a multi-parametric
`approach, Plenary presentation, OSA Biophotonics Congress: Biomedical Optics, Hollywood,
`FL
`May 2018 Bringing functional high resolution diagnostics to the bedside using multimodal, label-free, two-
`photon imaging, Tutorial presentation, OSA CLEO 2018, San Jose, CA
`Jun 2018 Understanding cellular metabolism using label-free, two-photon imaging, Second Britton
`Chance International Symposium on Metabolic Imaging and Spectroscopy, University of
`Pennsylvania, PA
`Nov 2018 Label-free, non-invasive high resolution imaging of tissue structure and function, Converging
`on Cancer seminar series, Tufts University, Medford, MA
`Feb 2019 Assessing adipose tissue type and function using multi-modal, label-free non-linear imaging.
`Leica workshop on CRS microscopy, Konstanz, Germany
`Mar 2019 Assessing tissue metabolic and biomechanical function through label-free, high resolution
`imaging, Photonics Center Seminar Series, Boston University, Boston, MA
`Apr 2019 Unraveling tissue morpho-functional metabolic secrets using label-free two-photon imaging,
`Biomedical Engineering Department Seminar Series, University of Wisconsin-Madison,
`Madison, WI
`Apr 2019 Label-free, high-resolution tissue imaging, Plenary speaker, Immunology department retreat,
`Tufts University, Boston, MA
`Apr 2019 Label-free, optical, morpho-functional cancer biomarkers, Optics in Life Sciences Biophotonics
`Congress, Tuscon, AZ
`May 2019 Label-free high resolution imaging of cellular metabolic function in live tissues, Frontiers in
`Imaging Science II, Janelia Farms, Ashburn, VA
`Jun 2019 Label-free metabolic tissue imaging and its potential to assess inflammatory responses,
`Imaging Inflammation Workshop, National Institutes of Health, Bethesda, MD
`
`Sept 2019 Label‐free, morpho-functional, high resolution tissue imaging for cancer diagnosis, Center for
`Oct 2019 Label‐free, morpho-functional, high resolution tissue imaging for cancer diagnosis, Zheijiang
`
`Engineering in Medicine, Massachusetts General Hospital/MIT/Shriners Burn Hospital, Boston,
`MA
`
`University, Hangzhou, China
`Feb 2020 Optical, label-free metabolic imaging, SPIE Photonics West, San Francisco, CA
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`Irene Georgakoudi, PhD
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`Feb 2020 Label free two photon microscopic imaging to assess tissue metabolic and biomechanical
`function, SPIE Photonics West, San Francisco, CA
`Feb 2020 Assessing Tissue Metabolic and Biomechanical Function Through Label-Free, High Resolution
`Imaging, Biomedical Engineering Department Seminar Series, Columbia University, New York
`City, NY
`Mar 2020 Assessing Tissue Metabolic and Biomechanical Function Through Label-Free, High Resolution
`Imaging, Biomedical Engineering Department Seminar Series, Vanderbilt University, Nashville,
`TN
`Apr 2020 Multiparametric, label-free two photon imaging of metabolic function. Photonics Europe (virtual)
`Oct 2020 Women in STEM careers, The Islamia University of Bahawalpur, Pakistan (virtual)
`Nov 2020 Morphofunctional Tissue Assessment Through Label-free, High Resolution Imaging, Wallace
`H. Coulter Foundation Biomedical Engineering Seminar Series, Florida International University,
`Miami, FL (virtual)
`Feb 2021 Non-linear optical microscopic imaging and its role in improving disease diagnosis. University
`of Massachusetts at Lowell, Physics Department Seminar Series (virtual)
`Mar 2021 Label free two photon microscopic imaging to assess tissue morphology and function, Label-
`free Biomedical Imaging and Spectroscopy Track, SPIE Photonics West (virtual)
`Apr 2021 Label-free, two photon imaging to assess tissue morphology and function, Biomedical
`Engineering and Instrumental Summit (Keynote lecture)
`Sep 2021 Assessing Tissue Metabolic and Biomechanical Function Through Label-Free, High Resolution
`Imaging, Biomedical Engineering Department Seminar Series, Temple University (Virtual)
`Dec 2021 Label-free, non-destructive imaging of mitochondrial function: From Organelles to Humans,
`Mitochondrial Dysfunction as a Universal Driver for Increased Health Risks: from COVID to
`Cosmos Workshop (Keynote Lecture)
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`PEER-REVIEWED PUBLICATIONS AND BOOK CHAPTERS
`1. Georgakoudi I, Nichols MG and Foster TH. The mechanism of Photofrin photobleaching and its
`consequences for photodynamic dosimetry. Photochem. Photobiol. 1997; 65: 135-144.
`2. Georgakoudi I and Foster TH. Singlet oxygen- versus nonsinglet oxygen-mediated mechanisms of
`sensitizer photobleaching and their effects on photodynamic dosimetry. Photochem. Photobiol.1998; 67:
`612-62.
`3. Georgakoudi I and Foster TH. Effects of the subcellular redistribution of two nile blue derivatives on
`photodynamic oxygen consumption. Photochem. Photobiol. 1998; 68: 115-122.
`4. Georgakoudi I, Keng PC and Foster TH. Hypoxia significantly reduces aminolaevulinic acid-induced
`protoporphyrin IX synthesis in EMT6 cells. Br. J. Cancer 1999; 79: 1372-1377.
`5. Yang C, Wax A, Georgakoudi I, et al. Interferometric phase-dispersion microscopy. Opt Letters 2000; 25:
`1526-1528.
`6. Coutier S, Mitra S, Bezdetnaya LN, Parache RM, Georgakoudi I, Foster TH and Guillemin F. Effects of
`fluence rate on cell survival and photobleaching in meta-tetra (hydroxyphenyl) chlorin (mTHPC)
`photosensitized colo 26 multicell tumor spheroids. Photochem. Photobiol. 2001; 73: 297-301.
`7. Georgakoudi I, Jacobson BC, Van Dam J et al. Fluorescence, reflectance and light scattering spectroscopy
`for evaluating dysplasia in patients with Barrett’s esophagus. Gastroenterology 2001; 120: 1620-1629.
`8. Bigelow CE, Harkrider CJ, Conover DL, Foster TH, Georgakoudi I, Mitra S, Nichols MG and Rajadhyaksha
`M. Retrofit design and implementation of confocal scanning using a commercial inverted fluorescence
`microscope platform. Review of Scientific Instruments 2001; 72: 3407-3410.
`9. Müller MG, Georgakoudi I, Zhang Q, Wu J and Feld MS. Intrinsic fluorescence spectroscopy in turbid media:
`Disentangling effects of scattering and absorption. Applied Optics 2001; 40: 4633-4646.
`10. Gurjar R, Backman V, Perelman LT, Georgakoudi I, et al. Functional imaging of human epithelia with
`polarized light scattering spectroscopy. Nature Medicine 2001; 7: 1245-1248.
`11. Backman V, Gopal V, Kalashnikov M, Badizadegan K, Gurjar R, Wax A, Georgakoudi I, Mueller M, Boone
`CW, Dasari RD and Feld MS. Measuring cellular structure at submicron scale with light scattering
`spectroscopy. IEEE J Sel Top Quantum Electron 2001; 7: 887-893.
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`Petitioner's Exhibit 1005
`Page 8 of 18
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`Irene Georgakoudi, PhD
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`12. Georgakoudi I, Jacobson BC, Mueller MG, Sheets EE, Badizadegan K, Carr-Locke D, Crum CP, Boone
`CW, Dasari RR, Van Dam J and Feld MS. NAD(P)H and collagen as quantitative fluorescent biomarkers of
`epithelial precancerous changes. Cancer Research 2002; 62: 682-687.
`13. Georgakoudi I, Sheets EE, Mueller M, Backman V, Crum CP, Badizadegan K and Feld MS. Tri-modal
`spectroscopy as a tool for the detection and biochemical/morphological characterization of cervical pre-
`cancers in vivo. American Journal of Obstetrics and Gynecology 2002; 186: 374-382.
`14. Mueller M, Wax A, Georgakoudi I, Galindo L, Dasari R, Feld M. Multiexcitation fluorescence and reflectance
`portable spectrofluorimeter to assist real time guidance to biopsy in precancer screening. Review of
`Scientific Instruments 2002; 73: 3933-393.
`15. Mueller M, Valdez T, Georgakoudi I, Backman V, Fuentes C, Kabani S, Laver N, Wang Z, Boone C, Dasari
`R, Shapsay S and Feld MS. Spectroscopic detection and evaluation of morphologic and biochemical
`changes in early human oral carcinoma. Cancer 2003; 97:1681-1692.
`16. Tunnell JW, Desjardins AE, Galindo L, Georgakoudi I, McGee SA, Mirkovic J, Mueller MG, Nazemi J,
`Nguyen FT, Wax A, Zhang Q, Dasari RR, Feld MS. Instrumentation for multi-modal spectroscopic diagnosis
`of epithelial dysplasia. Technol Cancer Res Treat. 2003; 2: 505-14.
`17. Badizadegan K, Backman V, Boone CW, Crum CP, Dasari RR, Georgakoudi I, Keefe K, Munger K,
`Shapshay S, Sheets EE, Feld MS. Spectroscopic diagnosis and imaging of invisible pre-cancer. Faraday
`Discuss 2004; 126: 265-279.
`18. Novak J, Georgakoudi I, Wei X, Prossin A, Lin C. An in vivo flow cytometer for real-time detection and
`quantification of circulating cells. Opt Lett 2004; 29: 77-79.
`19. Georgakoudi I, Solban N, Novak J, Rice W, Hasan T, Lin C. In vivo flow cytometry: A new method for
`enumerating circulating tumor cells. Cancer Res 2004; 64: 5044-5047.
`20. Wei X, Sipkins D, Pitsillides C, Novak J, Georgakoudi I, Lin C. Real-time detection of circulating apoptotic
`cells by in vivo flow cytometry. Mol Imaging 2005; 4: 415-416.
`21. Georgakoudi I, Van Dam J Characterization of Dysplastic Tissue Morphology and Biochemistry in Barrett’s
`Esophagus using Diffuse Reflectance and Light Scattering Spectroscopy. Techniques in Gastrointestinal
`Endoscopy 2005;7:100-105.
`22. Georgakoudi I. The Color of Cancer. J. Luminescence 2006;119-120: 75-83.
`23. Angheloiu G, Arendt, J, Müller, M, Haka, A, Georgakoudi I, Motz J, Scepanovic O, Kuban B, Myles J, Miller
`F, Podrez E, Fitzmaurice M, Kramer J, Feld M. Intrinsic fluorescence and diffuse reflectance spectroscopy
`identify superficial foam cells in coronary plaques prone to erosion. Arteriosclerosis, Thrombosis, and
`Vascular Biology 2006; 26:1594-600.
`24. Levitt Jg, Baldwin A, Papadakis A, Puri Su, Xylas Ju, Munger K, Georgakoudi I. Intrinsic fluorescence and
`redox c