`
`1111111111111111111111010!10111111119111,111111111111111110111111
`
`USO10786669B2
`
`( 12 ) United States Patent
`(12) United States Patent
`Rajguru et al .
`Rajguru et al.
`
`( 10 ) Patent No .: US 10,786,669 B2
`(10) Patent No.: US 10,786,669 B2
`* Sep . 29 , 2020
`( 45 ) Date of Patent :
`(45) Date of Patent:
`*Sep. 29, 2020
`
`( 58 )
`Field of Classification Search
`(58) Field of Classification Search
`??? ........ A61N 2/02 ; A61N 2/004 ; A61N 1/3787 ;
`CPC
` A61N 2/02; A61N 2/004; A61N 1/3787;
`A61N 1/36057 ; A61N 1/36021 ;
`A61N 1/36057; A61N 1/36021;
`( Continued )
`(Continued)
`References Cited
`References Cited
`U.S. PATENT DOCUMENTS
`U.S. PATENT DOCUMENTS
`
`( 56 )
`(56)
`
`2,003,392 A
`2,003,392 A
`2,893,392 A
`2,893,392 A
`
`6/1935 Rucker
`6/1935 Rucker
`7/1959 Wagner et al .
`7/1959 Wagner et al.
`( Continued )
`(Continued)
`FOREIGN PATENT DOCUMENTS
`FOREIGN PATENT DOCUMENTS
`
`CN
`CN
`EP
`EP
`
`3/1994
`1083402
`3/1994
`1083402
`2456512
`5/2012
`5/2012
`2456512
`( Continued )
`(Continued)
`
`OTHER PUBLICATIONS
`OTHER PUBLICATIONS
`Chang , Qwang - Yuen , et al .
`“ Effect of Electroacupuncture and
`Chang, Qwang-Yuen, et al. "Effect of Electroacupuncture and
`Transcutaneous Electrical Nerve Stimulation at Hegu ( LI.4 ) Acu
`Transcutaneous Electrical Nerve Stimulation at Hegu (LI.4) Acu-
`puncture Point on the Cutaneous Reflex . ” 2002. Acupuncture &
`puncture Point on the Cutaneous Reflex." 2002. Acupuncture &
`Electro - Therapeutics Research . vol . 27 , Nos . 3-4 . pp . 191-202 .
`Electro-Therapeutics Research. vol. 27, Nos. 3-4. pp. 191-202.
`( Abstract Only ) ( Year : 2002 ) . *
`(Abstract Only) (Year: 2002).*
`( Continued )
`(Continued)
`Primary Examiner Carl H Layno
`Primary Examiner — Carl H Layno
`Assistant Examiner Jon Eric C Morales
`Assistant Examiner — Jon Eric C Morales
`( 74 ) Attorney , Agent , or Firm — Levine Bagade Han LLP
`(74) Attorney, Agent, or Firm — Levine Bagade Han LLP
`( 57 )
`ABSTRACT
`ABSTRACT
`(57)
`The disclosure describes devices and methods for providing
`The disclosure describes devices and methods for providing
`transdermal electrical stimulation therapy to a subject
`transdermal electrical stimulation therapy to a subject
`including positioning a stimulator electrode over a glabrous
`including positioning a stimulator electrode over a glabrous
`skin surface overlying a palm of the subject and delivering
`skin surface overlying a palm of the subject and delivering
`electrical stimulation via a pulse generator transdermally
`electrical stimulation via a pulse generator transdermally
`through the glabrous skin surface and to a target nerve or
`through the glabrous skin surface and to a target nerve or
`tissue within the hand to stimulate the target nerve or tissue
`tissue within the hand to stimulate the target nerve or tissue
`within the hand so that pain felt by the subject is mitigated .
`within the hand so that pain felt by the subject is mitigated.
`The pulses generated during the electrical stimulation
`The pulses generated during the electrical stimulation
`therapy may include pulses of two different magnitudes .
`therapy may include pulses of two different magnitudes.
`20 Claims , 72 Drawing Sheets
`20 Claims, 72 Drawing Sheets
`
`22
`22
`
`28
`
`( 54 ) METHOD AND APPARATUS FOR
`(54) METHOD AND APPARATUS FOR
`TRANSDERMAL STIMULATION OVER THE
`TRANSDERMAL STIMULATION OVER THE
`PALMAR AND PLANTAR SURFACES
`PALMAR AND PLANTAR SURFACES
`( 71 ) Applicant : EMKinetics , Inc. , San Francisco , CA
`(71) Applicant: EMKinetics, Inc., San Francisco, CA
`( US )
`(US)
`( 72 ) Inventors : Amit Rajguru , Lafayette , CA ( US ) ;
`(72)
`Inventors: Amit Rajguru, Lafayette, CA (US);
`Daniel R. Burnett , San Francisco , CA
`Daniel R. Burnett, San Francisco, CA
`( US ) ; Alexander Vergara , San
`(US); Alexander Vergara, San
`Francisco , CA ( US ) ; Michael Hemati ,
`Francisco, CA (US); Michael Hemati,
`San Francisco , CA ( US )
`San Francisco, CA (US)
`( 73 ) Assignee : EMKinetics , Inc. , San Francisco , CA
`(73) Assignee: EMKinetics, Inc., San Francisco, CA
`( US )
`(US)
`Subject to any disclaimer , the term of this
`Subject to any disclaimer, the term of this
`patent is extended or adjusted under 35
`patent is extended or adjusted under 35
`U.S.C. 154 ( b ) by 514 days .
`U.S.C. 154(b) by 514 days.
`This patent is subject to a terminal dis
`This patent is subject to a terminal dis-
`claimer .
`claimer.
`( 21 ) Appl . No .: 15 / 474,875
`(21) Appl. No.: 15/474,875
`( 22 ) Filed :
`Mar. 30 , 2017
`(22) Filed:
`Mar. 30, 2017
`( 65 )
`Prior Publication Data
`(65)
`Prior Publication Data
`Sep. 21 , 2017
`US 2017/0266443 A1
`US 2017/0266443 Al
`Sep. 21, 2017
`
`( * ) Notice :
`( * ) Notice:
`
`Related U.S. Application Data
`Related U.S. Application Data
`( 63 ) Continuation - in - part of application No. 15 / 084,356 ,
`(63) Continuation-in-part of application No. 15/084,356,
`filed on Mar. 29 , 2016 , now Pat . No. 9,630,004 ,
`filed on Mar. 29, 2016, now Pat. No. 9,630,004,
`( Continued )
`(Continued)
`
`( 51 ) Int . Ci .
`(51) Int. Cl.
`A61N 1/34
`A61N 1/34
`A61N 1/04
`A61N 1/04
`
`( 52 ) U.S. Cl .
`(52) U.S. Cl.
`CPC
`CPC
`
`( 2006.01 )
`(2006.01)
`( 2006.01 )
`(2006.01)
`( Continued )
`(Continued)
`
`A61N 1/36021 ( 2013.01 ) ; A61N 1/0456
` A61N 1/36021 (2013.01); A61N 1/0456
`( 2013.01 ) ; A61N 1/36007 ( 2013.01 ) ;
`(2013.01); A61N 1/36007 (2013.01);
`( Continued )
`(Continued)
`
`2
`
`24
`30
`
`C
`
`Petitioner - Avation Medical, Inc.
`Ex. 1018, p. 1
`
`

`

`US 10,786,669 B2
`US 10,786,669 B2
`Page 2
`Page 2
`
`Related U.S. Application Data
`Related U.S. Application Data
`which is a continuation of application No. 13/840 ,
`which is a continuation of application No. 13/840,
`936 , filed on Mar. 15 , 2013 , now Pat . No. 9,339,641 ,
`936, filed on Mar. 15, 2013, now Pat. No. 9,339,641,
`which is a continuation - in - part of application No.
`which is a continuation-in-part of application No.
`PCT / US2011 / 052415 , filed on Sep. 20 , 2011 , appli
`PCT/US2011/052415, filed on Sep. 20, 2011, appli-
`cation No. 15 / 474,875 , which is a continuation - in
`cation No. 15/474,875, which is a continuation-in-
`part of application No. 12 / 508,529 , filed on Jul . 23 ,
`part of application No. 12/508,529, filed on Jul. 23,
`2009 , now abandoned , which is a continuation - in - part
`2009, now abandoned, which is a continuation-in-part
`of application No. 11 / 866,329 , filed on Oct. 2 , 2007 ,
`of application No. 11/866,329, filed on Oct. 2, 2007,
`now abandoned .
`now abandoned.
`
`( 60 ) Provisional application No. 62 / 350,610 , filed on Jun .
`(60) Provisional application No. 62/350,610, filed on Jun.
`15 , 2016 , provisional application No. 61 / 403,680 ,
`15, 2016, provisional application No. 61/403,680,
`filed on Sep. 20 , 2010 , provisional application No.
`filed on Sep. 20, 2010, provisional application No.
`60 / 848,720 , filed on Oct. 2 , 2006 .
`60/848,720, filed on Oct. 2, 2006.
`( 51 ) Int . Ci .
`(51) Int. Cl.
`A61N 1/36
`A61N 1/36
`A61N 2/02
`A61N 2/02
`A61N 1/378
`A61N 1/378
`A61N 2/00
`A61N 2/00
`A61B 5/00
`A61B 5/00
`A61N 1/05
`A61N 1/05
`( 52 ) U.S. CI .
`(52) U.S. Cl.
`CPC
`CPC
`
`( 2006.01 )
`(2006.01)
`( 2006.01 )
`(2006.01)
`( 2006.01 )
`(2006.01)
`( 2006.01 )
`(2006.01)
`( 2006.01 )
`(2006.01)
`( 2006.01 )
`(2006.01)
`
`( 56 )
`(56)
`
`A61N 1/36057 ( 2013.01 ) ; A61N 2/02
` A61N 1/36057 (2013.01); A61N 2/02
`( 2013.01 ) ; A61B 5/4047 ( 2013.01 ) ; A6IN
`(2013.01); A61B 5/4047 (2013.01); A61N
`1/0551 ( 2013.01 ) ; A61N 1/36017 ( 2013.01 ) ;
`1/0551 (2013.01); A61N 1/36017 (2013.01);
`A61N 1/3787 ( 2013.01 ) ; A61N 2/004
`A61N 1/3787 (2013.01); A61N 2/004
`( 2013.01 )
`(2013.01)
`Field of Classification Search
`( 58 )
`(58) Field of Classification Search
`CPC ............ A61N 1/36017 ; A61N 1/36007 ; A61N
`CPC
`A61N 1/36017; A61N 1/36007; A61N
`1/0551 ; A61N 1/0456 ; A61B 5/4047
`1/0551; A61N 1/0456; A61B 5/4047
`USPC
`607/144
` 607/144
`USPC
`See application file for complete search history .
`See application file for complete search history.
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`Petitioner - Avation Medical, Inc.
`Ex. 1018, p. 2
`
`

`

`US 10,786,669 B2
`US 10,786,669 B2
`Page 3
`Page 3
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`Petitioner - Avation Medical, Inc.
`Ex. 1018, p. 3
`
`

`

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