1 CLUSTAL O(1.2.4) multiple sequence alignment
`2
`3
`4 NP_003108.2 MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPV
`5 XP_003318802.2 MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPV
`6 XP_003261317.2 MGVLKFKHIFFRSFVKSNGISQIVF-TF----------------LLIPRCLTLNFRAPPV
`7 XP_001086882.2 MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPI
`8 NP_001076141.2 MGVLKFKHIFFGSAVEFNRAFQILY-IF----------------LLIPCCLTANFRAPPV
`9 XP_002919069.1 MAVLRFQRIFFRSFVGSRGATPVVL-TF----------------LLIPCCLTQEFRAPPF
`10 NP_999176.1 MGVQRLQHISFRSFFVPSGAPQVVF-TF----------------LLIPCCLALDFRASPI
`11 XP_002686960.3 --MLRHQHISFRNFVGSNGAPQAVF-TF----------------LLVPCCLALNFTAPPL
`12 NP_001008413.3 MRMLRRHHISFRSFAGSSGTPQAVF-TF----------------LLLPCCLALDFRAPPL
`13 XP_003502178.1 MRVLCLKHSFSGSFLESNGAPQTVL-VF----------------LLLPCCLTGDFRAPPL
`14 NP_001166492.1 MGAFTFKHSFFGSFVECSGVLQTVF-IF----------------LLIPCCLA-DKRAPPL
`15 NP_001019492.1 MRVLCFKHSFFGSLLESSGLPQTLL-VF----------------LLIRCCLTVDFRAPPL
`16 XP_001507937.2 ----RLPHLSSGSWAVCCQASWVAV-VL----------------QLLPWCMALDIQAPPM
`17 NP_001073344.1 MGELRFKHLFWGSFVESGGTFQTVL-IF----------------LLIPCSLTVDYRAAPI
`18 XP_003502177.1 MGGLPLKHLFWGSFVVSRATFQTVLIIF----------------LLIPCSLTVDYRGGPL
`19 XP_002190553.4 -------------------ASGVVF-AT----------------LLVSCCSSLNIRARPL
`20 XP_002932242.3 MERVNCEHILYKKLL--------CILCS----------------FLIHTCQSMDMKAPTN
`21 NP_001082194.1 -----FQHVLCKKCI--------CILLF----------------CFITSCQSMDIKAPTN
`22 XP_002919077.1 MKVLSEGQLRFCVVQPIHLTSC--LVIF----------------IILKSISSLKPARLPI
`23 XP_002712114.1 ----------------------------------------------------------PI
`24 XP_532444.4 ------------------------LLIF----------------FILKSISSLKPARLPI
`25 XP_002818436.2 ----------------------------------------------------------PI
`26 NP_084124.1 ----------------------------------------------------------PV
`27 XP_003134772.2 ------------------------LLIF----------------FILKSISSLKPARLPV
`28 NP_036401.2 ----------------------------------------------------------PI
`29 XP_003261316.2 MKVLSEGHLRLCVVQPVHLTSW--LLIF----------------FILKSISCLKPAQLPI
`30 XP_003407292.1 -------------------SSW--LLIF----------------FILKSISSLKPARLPI
`31 XP_003586042.1 ------------------------LFIL----------------FILKSISSLKPARLPV
`32 NP_001094250.1 ----------RCVVQPVHLTSG--LLIF----------------FILKSISSLKPARLPV
`33 XP_003221368.2 ----------------------------------------------------------PI
`34 XP_003475093.1 -------------IQSIHLTPW--LLVF----------------LSLKSVCSLKPARLPL
`35 NP_001090796.1 ----------------------------------------------------------PF
`36 XP_003221369.1 ----------------------------------------------------------PL
`37 XP_003449274.1 ----------------------------------------------------------PL
`38 NP_001074140.1 ----------------------------------------------------------PL
`39 XP_003217669.1 ----------------------------------------------------------PI
`40 XP_001507903.3 -------------------LSW--LLIS----------------FLLELTSSLKPAQHPI
`41 XP_003449275.2 ---------------------------------------------------------PPL
`42 XP_001378617.3 --------------------------------------------------------APPI
`43 XP_003210019.2 --------------------------------------------------------AAPL
`44 XP_414258.3 ---------------------------LVPA-----------VLAVLARQSPEKPSAAPL
`45 NP_001080777.1 ----------------------------------------------------------PV
`46 NP_001119986.1 -------------------------LSFLPA--FLWLFLGAAANGQLSDSWLNKPTFRPV
`47 XP_003221370.3 --------------------------------------------FMLVDGSTAMPTRAPL
`48 XP_003448364.1 ---------------------------LLIV--PLWDCL---------FALGLKPTRWPL
`49 XP_002189602.4 ----------------------------------------------------------PV
`50 NP_001074154.2 ------------------------------------------------------------
`51 XP_003448436.2 ----------------------------VL---LHL--------ILISLVSGLHYPNSP-
`52 XP_002813763.3 -----------------------------LA--VAW-------------AMELKPTAPPI
`53 XP_002935681.1 ---------------------------------YTF--------LLSGLLGWLAAGTDPV
`54 XP_001168599.1 -----------------------------LA--VAW-------------AMELKPTAPPI
`55 XP_687640.2 ---------HLSGTTRTQRASW--LQVLLLM--LFWTCL---------KAQQLKNTRWPL
`56 NP_003764.3 -----------------------------LA--VSW-------------AMELKPTAPPI
`57 XP_003476739.1 -----------AGLGPI----V--TLALVLP--VAW-------------AMELKPTGPPI
`58 XP_003257153.1 -----------------------------LA--VAW-------------AMELKPTAPPI
`59 XP_002758427.1 -----------------------------LV--VAW-------------AMELKPTAPPI
`60 XP_001102414.2 ----------------------------------------------------------PL
`61 NP_742037.2 --------------------------------------------------------APPI
`62 NP_999605.1 -----------------------------LA--VAW-------------ATELKPTAPPI
`63 NP_001009754.1 -----------------------------LV--VAW-------------ATELKPTAPPI
`64 NP_083196.2 ---------------------------------VLF--------VLLVAPAALKPAMPPV
`65 NP_001019491.1 ---------------------------------------------------------PPV
`66 NP_776772.1 -----------------------------LV--VAW-------------ATELKPTAPPI
`
`43
`43
`43
`43
`43
`43
`43
`41
`43
`43
`42
`43
`39
`43
`44
`24
`36
`31
`42
`2
`20
`2
`2
`20
`2
`42
`23
`20
`32
`2
`29
`2
`2
`2
`2
`2
`23
`3
`4
`4
`22
`2
`33
`16
`22
`2
`0
`20
`16
`19
`16
`38
`16
`28
`16
`16
`2
`4
`16
`16
`19
`3
`16
`
`Petitioner Merck, Ex. 1057, p. 1
`
`
`2
`3
`4 NP_003108.2 MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPV
`5 XP_003318802.2 MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPV
`6 XP_003261317.2 MGVLKFKHIFFRSFVKSNGISQIVF-TF----------------LLIPRCLTLNFRAPPV
`7 XP_001086882.2 MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPI
`8 NP_001076141.2 MGVLKFKHIFFGSAVEFNRAFQILY-IF----------------LLIPCCLTANFRAPPV
`9 XP_002919069.1 MAVLRFQRIFFRSFVGSRGATPVVL-TF----------------LLIPCCLTQEFRAPPF
`10 NP_999176.1 MGVQRLQHISFRSFFVPSGAPQVVF-TF----------------LLIPCCLALDFRASPI
`11 XP_002686960.3 --MLRHQHISFRNFVGSNGAPQAVF-TF----------------LLVPCCLALNFTAPPL
`12 NP_001008413.3 MRMLRRHHISFRSFAGSSGTPQAVF-TF----------------LLLPCCLALDFRAPPL
`13 XP_003502178.1 MRVLCLKHSFSGSFLESNGAPQTVL-VF----------------LLLPCCLTGDFRAPPL
`14 NP_001166492.1 MGAFTFKHSFFGSFVECSGVLQTVF-IF----------------LLIPCCLA-DKRAPPL
`15 NP_001019492.1 MRVLCFKHSFFGSLLESSGLPQTLL-VF----------------LLIRCCLTVDFRAPPL
`16 XP_001507937.2 ----RLPHLSSGSWAVCCQASWVAV-VL----------------QLLPWCMALDIQAPPM
`17 NP_001073344.1 MGELRFKHLFWGSFVESGGTFQTVL-IF----------------LLIPCSLTVDYRAAPI
`18 XP_003502177.1 MGGLPLKHLFWGSFVVSRATFQTVLIIF----------------LLIPCSLTVDYRGGPL
`19 XP_002190553.4 -------------------ASGVVF-AT----------------LLVSCCSSLNIRARPL
`20 XP_002932242.3 MERVNCEHILYKKLL--------CILCS----------------FLIHTCQSMDMKAPTN
`21 NP_001082194.1 -----FQHVLCKKCI--------CILLF----------------CFITSCQSMDIKAPTN
`22 XP_002919077.1 MKVLSEGQLRFCVVQPIHLTSC--LVIF----------------IILKSISSLKPARLPI
`23 XP_002712114.1 ----------------------------------------------------------PI
`24 XP_532444.4 ------------------------LLIF----------------FILKSISSLKPARLPI
`25 XP_002818436.2 ----------------------------------------------------------PI
`26 NP_084124.1 ----------------------------------------------------------PV
`27 XP_003134772.2 ------------------------LLIF----------------FILKSISSLKPARLPV
`28 NP_036401.2 ----------------------------------------------------------PI
`29 XP_003261316.2 MKVLSEGHLRLCVVQPVHLTSW--LLIF----------------FILKSISCLKPAQLPI
`30 XP_003407292.1 -------------------SSW--LLIF----------------FILKSISSLKPARLPI
`31 XP_003586042.1 ------------------------LFIL----------------FILKSISSLKPARLPV
`32 NP_001094250.1 ----------RCVVQPVHLTSG--LLIF----------------FILKSISSLKPARLPV
`33 XP_003221368.2 ----------------------------------------------------------PI
`34 XP_003475093.1 -------------IQSIHLTPW--LLVF----------------LSLKSVCSLKPARLPL
`35 NP_001090796.1 ----------------------------------------------------------PF
`36 XP_003221369.1 ----------------------------------------------------------PL
`37 XP_003449274.1 ----------------------------------------------------------PL
`38 NP_001074140.1 ----------------------------------------------------------PL
`39 XP_003217669.1 ----------------------------------------------------------PI
`40 XP_001507903.3 -------------------LSW--LLIS----------------FLLELTSSLKPAQHPI
`41 XP_003449275.2 ---------------------------------------------------------PPL
`42 XP_001378617.3 --------------------------------------------------------APPI
`43 XP_003210019.2 --------------------------------------------------------AAPL
`44 XP_414258.3 ---------------------------LVPA-----------VLAVLARQSPEKPSAAPL
`45 NP_001080777.1 ----------------------------------------------------------PV
`46 NP_001119986.1 -------------------------LSFLPA--FLWLFLGAAANGQLSDSWLNKPTFRPV
`47 XP_003221370.3 --------------------------------------------FMLVDGSTAMPTRAPL
`48 XP_003448364.1 ---------------------------LLIV--PLWDCL---------FALGLKPTRWPL
`49 XP_002189602.4 ----------------------------------------------------------PV
`50 NP_001074154.2 ------------------------------------------------------------
`51 XP_003448436.2 ----------------------------VL---LHL--------ILISLVSGLHYPNSP-
`52 XP_002813763.3 -----------------------------LA--VAW-------------AMELKPTAPPI
`53 XP_002935681.1 ---------------------------------YTF--------LLSGLLGWLAAGTDPV
`54 XP_001168599.1 -----------------------------LA--VAW-------------AMELKPTAPPI
`55 XP_687640.2 ---------HLSGTTRTQRASW--LQVLLLM--LFWTCL---------KAQQLKNTRWPL
`56 NP_003764.3 -----------------------------LA--VSW-------------AMELKPTAPPI
`57 XP_003476739.1 -----------AGLGPI----V--TLALVLP--VAW-------------AMELKPTGPPI
`58 XP_003257153.1 -----------------------------LA--VAW-------------AMELKPTAPPI
`59 XP_002758427.1 -----------------------------LV--VAW-------------AMELKPTAPPI
`60 XP_001102414.2 ----------------------------------------------------------PL
`61 NP_742037.2 --------------------------------------------------------APPI
`62 NP_999605.1 -----------------------------LA--VAW-------------ATELKPTAPPI
`63 NP_001009754.1 -----------------------------LV--VAW-------------ATELKPTAPPI
`64 NP_083196.2 ---------------------------------VLF--------VLLVAPAALKPAMPPV
`65 NP_001019491.1 ---------------------------------------------------------PPV
`66 NP_776772.1 -----------------------------LV--VAW-------------ATELKPTAPPI
`
`43
`43
`43
`43
`43
`43
`43
`41
`43
`43
`42
`43
`39
`43
`44
`24
`36
`31
`42
`2
`20
`2
`2
`20
`2
`42
`23
`20
`32
`2
`29
`2
`2
`2
`2
`2
`23
`3
`4
`4
`22
`2
`33
`16
`22
`2
`0
`20
`16
`19
`16
`38
`16
`28
`16
`16
`2
`4
`16
`16
`19
`3
`16
`
`Petitioner Merck, Ex. 1057, p. 1
`
`
`
`67 NP_149349.2 ---------------------------LLP---ICA--------LFLTLLDMAQGFRGPL
`68 NP_001035086.1 ----------------------------------------------------------P-
`69 XP_003502176.1 ---------------------------------------------------------PPV
`70 XP_003257149.1 ----------------------------------------------------------PL
`71 XP_002813766.6 ----------------------------------------------------------PL
`72 NP_001017941.1 ---------------------------LLP---VCT--------LFLNLLSMTQGSRDPV
`73 XP_002920567.1 ----------------------------------------------------------PM
`74 XP_003476738.1 ----------------------------------------------------------PV
`75 NP_999606.1 ---------------------------LLP---ICT--------LFLNLLSVAQGSRDPV
`76 XP_002713406.3 -----------------------------------------------------------T
`77 XP_003500449.1 -----------------------------------------------------------T
`78 XP_001509131.1 ----------------------------------------------------------PV
`79 XP_001139800.4 ---------------------------------------------------------PPV
`80 NP_032343.3 -----------------------------------------------------------V
`81 NP_997499.2 -----------------------------------------------------------M
`82 XP_001168796.1 ---------------------------LLP---ICA--------LFLTLLDMAQGFRGPL
`83 NP_997482.2 ----------------ITQLGL--TLVV------------------GLTLCLVHVQALLQ
`84 NP_001193181.1 ------------------------------------------------------------
`85 NP_001186958.1 -------------------------LVL------------------GVALCLGCGQPLPQ
`86 NP_999604.1 ------------------------------------------------------------
`87 XP_001493753.3 ------------------------------------------------------------
`88 NP_001121765.1 -----------------------------------------------------------V
`89 NP_821139.2 ------------------------------------------------------------
`90 XP_002128103.1 -------------------MSF--SYVFLALGILGSVCHSQSLQS-YLTTSLKDNIWQPP
`91 XP_003642042.3 ------------------------------------------------------------
`92
`93
`94 NP_003108.2 IPNVPFLWAWNAPSEFCLG-KFDEPLD---MS-LFSFIGSPRINATGQGVTIFYVDRLGY
`95 XP_003318802.2 IPNVPFLWAWNAPSEFCLG-KFDEPLD---MS-LFSFIGSPRINVTGQDVTIFYVDRLGY
`96 XP_003261317.2 IPNVPFLWAWNAPSEFCLG-KFDEPLD---MS-LFSLTGSPRINVTGQGVTIFYVDRLGY
`97 XP_001086882.2 IPNVPFLWAWNAPSEFCLG-KFNEPLD---MS-LFTLMGSPRINITGQGVTIFYVDRLGY
`98 NP_001076141.2 IPNVPFLWAWNAPTELCLG-KSGEPLD---TS-LFSLFGSPSKDKTGQGITIFYVDRLGY
`99 XP_002919069.1 IPNVSFLWGWNAPTELCAQ-KFNVQLD---LN-LFSLIGSPQKSATGQGITLFYANRLGY
`100 NP_999176.1 IPNTTFLWVWNAPTESCAK-KFYMPPD---LS-LFSFVTSPRASVTGQFLTLFYANRLGY
`101 XP_002686960.3 IPNIPFLWAWNAPTNHCAE-IFSMPPD---LG-LFSLVGSPQKDVTGQPITLFYADRLGY
`102 NP_001008413.3 ISNTSFLWAWNAPVERCVNRRFQLPPD---LR-LFSVKGSPQKSATGQFITLFYADRLGY
`103 XP_003502178.1 IPNVPFLWVWNAPTESCLT-KFNEPLD---LS-LFSLVGSPKKSATGQPITIFYTDRLGF
`104 NP_001166492.1 IPNVPLLWVWNAPTEFCIG-GTNQPLD---MS-FFSIVGTPRKNITGQSITLYYVDRLGY
`105 NP_001019492.1 IPNVPFLCAWNAPTESCAT-RFNQPLD---LS-LFSLVGSPRKTAIGHPVTIFYSDRLGL
`106 XP_001507937.2 IPNLPFLSAWNAPTELCAQ-KHDVELD---MS-LFSLVGSTRQEIKGQNITLFYTDRLGY
`107 NP_001073344.1 LSNTTFLWIWNVPTERCVG-NVNDPID---LS-FFSLIGSPRKTATGQPVTLFYVDRLGL
`108 XP_003502177.1 LPSEILIWVWNVPTEACIG-NFSHSID---LS-LFPIVGSPRKTATGQPVTLFYVDRLGY
`109 XP_002190553.4 LSNSPFLSIWNAPTELCTE-RTGVQLD---MN-FFPLIGSTLKTSVGQNITLFYPDRIGY
`110 XP_002932242.3 GP-ANFMAIWNAPTELCMR-KFKVNID---IS-LFQITGSPESSTIAQNITIFYTDRLGY
`111 NP_001082194.1 GL-SNFMAIWNAPTELCLQ-KFKVKID---VS-LFQIVGTTFNSSIAQNITIFYTDRLGH
`112 XP_002919077.1 YQRKPFIAAWNAPTDQCLI-KYNIGLN---LK-MFQVIGSPLAKARGQNVTIFYVNRLGY
`113 XP_002712114.1 YQRKPFIAAWNAPTDQCLM-KYNLKLN---LK-MFQVIGSPLAKARGQNVTIFYVNRLGY
`114 XP_532444.4 YQRKPFIAAWNAPTDQCLI-KYNIGLN---LK-MFQVIGSPLAKARGQNITIFYVNRLGY
`115 XP_002818436.2 YQRKPFIAAWNAPTDQCLI-KYNLRLN---LK-IFPVIGSPLAKARGQNVTIFYVNRLGY
`116 NP_084124.1 YQRKPFIAAWNAPTDLCLI-KYNLTLN---LK-VFQMVGSPRLKDRGQNVVIFYANRLGY
`117 XP_003134772.2 YQRKPFIAAWNAPTDQCLI-KYNVRLN---LK-MFQVIGSPLARARGQNVTIFYVNRLGY
`118 NP_036401.2 YQRKPFIAAWNAPTDQCLI-KYNLRLN---LK-MFPVIGSPLAKARGQNVTIFYVNRLGY
`119 XP_003261316.2 YQRKPFIAAWNAPTDQCLI-KYNLRLN---LK-MFPVIGSPLAKARGQNVTIFYVNRLGY
`120 XP_003407292.1 YQRKPFIAAWNAPTDQCLI-KYNIRLN---LK-MFQVVGSPLAKARGQNVTIFYVNRLGY
`121 XP_003586042.1 YQRKPFIAAWNAPTDQCLI-KYNIRLN---LK-MFQVIGSPLARARGQNVTIFYVNRLGY
`122 NP_001094250.1 YQRKPFIAAWNAPTDLCLI-KYNLAVN---LK-VFQMVGSPRLKDRRQNVVIFYANKLGS
`123 XP_003221368.2 SRRKPFIAAWNAPTDHCSI-RYNVTIN---LK-MFHVIGSPFAKARGQNVTIFYVNRLGY
`124 XP_003475093.1 YQRKPFIAAWNTPTDQCLM-KYKLRLN---LE-MFQVAGSTLTKARGQNVTIFYPRRLGY
`125 NP_001090796.1 IQNKPFLAVWNAPTEQCKQ-RYKVDLD---LS-IFDIVANPNETLIGSNVTIFYHTHLGH
`126 XP_003221369.1 FPNKAFVVVWNAPTEQCRL-RYDVDLD---LN-VFNVLSNPNETLSGPTVTIFYHTRLGY
`127 XP_003449274.1 IGRKPFIAAWNAPLDLCTF-RYNITTN---VNHLFHIQGSPRADWTGQNVTIFYANRLGY
`128 NP_001074140.1 LPHRPFVVVWNAPTESCRL-RFKVDLD---LS-VFDIVANHNETLSGPNVTIFYHSHLGY
`129 XP_003217669.1 FTRRPFIVAWNVPSQDCQP-RFKVQLD---FS-IFDLQASPNEGFVDQNLTIFYKERLGL
`130 XP_001507903.3 FQKKPFVAVWNAPTDQCLF-QYNTGIN---LR-TFHITGSPLAKARGQNVTIFFVNRLGY
`131 XP_003449275.2 IPHKPFVVVWNAPTESCRL-RFKVDLD---LS-IFDIVANLNETLSGPNVTIFYHSHLGY
`132 XP_001378617.3 FTRRPFLVAWNAPTQDCWP-RFRVSLN---FS-VFDVKASPNEGFVNQNLTIFYRDRLGY
`
`22
`1
`3
`2
`2
`22
`2
`2
`22
`1
`1
`2
`3
`1
`1
`22
`24
`0
`17
`0
`0
`1
`0
`38
`0
`
`98
`98
`98
`98
`98
`98
`98
`96
`99
`98
`97
`98
`94
`98
`99
`79
`90
`85
`97
`57
`75
`57
`57
`75
`57
`97
`78
`75
`87
`57
`84
`57
`57
`58
`57
`57
`78
`58
`59
`
`Petitioner Merck, Ex. 1057, p. 2
`
`
`
`133 XP_003210019.2 LTRRPFLVAWNAPTQDCKP-RFQVALD---FS-IFDLHASPNEGFVDQNLTIFYKERLGL
`134 XP_414258.3 LTRRPFLVAWNAPTQDCKP-RFQVALD---FS-VFDLQASPNEGFVDQNLTIFYKERLGL
`135 NP_001080777.1 FTRRPFIIAWNAPTQDCPP-RFNVHLD---LK-LFDLNASPNEGFVDQNLTIFYKERLGM
`136 NP_001119986.1 FTRRPFIIAWNAPTQDCPP-RFNVHLD---LK-LFDLNASPNEGFVDQNLTIFYKERLGM
`137 XP_003221370.3 FSKKAFVVVWNAPTEQCRL-RYSVDLD---LK-IFNILSNPNESLNGPIVTIFYANRLGF
`138 XP_003448364.1 YSRKPLLLAWNAPIEDCAP-RHKIRFQ---LD-QFQIVATPNEGFVNQNLTIFYKERLGL
`139 XP_002189602.4 LVNRPFVTIWNIPTERCAE-KYNVSLS---LE-VFDVLANDQQSFTGQDITLFYSDKIGL
`140 NP_001074154.2 ----PFVLLWNAPISKCHQ--LKVPLD---LS-LFQAVTTPAR-VHNQSLSLFYKTRLGL
`141 XP_003448436.2 FSKVPFLTVWNAPSANCLS-QYGVDLD---LG-MFNIVQNQNQTFMGQNITIFYAEKLGL
`142 XP_002813763.3 FTGRPFVVAWDVPTQDCGP-RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGL
`143 XP_002935681.1 LKGRPFASVWNAPTSPCLD-RFGVTLD---LS-AFDIVLNQNHTFQGSEVVIFYSSQLGF
`144 XP_001168599.1 FTGRPFVVAWDVPTQDCGP-RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGL
`145 XP_687640.2 YSGKPLLLAWNAPTEDCRP-RHDVTFQ---LD-QFQIVASPNEGFTKQNLTIFYQDRLGL
`146 NP_003764.3 FTGRPFVVAWDVPTQDCGP-RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGL
`147 XP_003476739.1 FTGRPFVVAWDVPTQDCGP-RHKVSLD---LK-AFDVQASPNEGFVNQSITIFYYDRLGL
`148 XP_003257153.1 FTGRPFVVAWDVPTQDCGP-RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGL
`149 XP_002758427.1 FTGRPFVVAWDVPTQDCGP-RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGL
`150 XP_001102414.2 LPNRPFATVWNANTQWCLE-RHSVDVD---VS-IFDVVANPGQTFRGPDMTIFYSSQLGT
`151 NP_742037.2 FTGRPFVVAWNVPTQECAP-RHKVPLD---LR-AFDVEATPNEGFFNQNITTFYYDRLGL
`152 NP_999605.1 FTGRPFVVAWDVPTQDCGP-RHKVPLDPKDMK-AFDVQASPNEGFVNQNITIFYRDRLGM
`153 NP_001009754.1 FTGRPFVVAWDVPTQDCGP-RHKMPLDPKDMK-AFDVQASPNEGFVNQNITIFYRDRLGM
`154 NP_083196.2 IKDHPFNVFWAAPTLFCKD-NFNVNMN---LQ-VFNIIPNPFETQSGSTITVFYPKELGY
`155 NP_001019491.1 IKNQPFNIFWAAPTLFCKD-NFDVNMN---LQ-AFNIIPNPFETQSGSTIAVFYPKELGY
`156 NP_776772.1 FTGRPFVVAWDVPTQDCGP-RHKMPLDPKDMK-AFDVQASPNEGFVNQNITIFYRDRLGM
`157 NP_149349.2 LPNRPFTTVWNANTQWCLE-RHGVDVD---VS-VFDVVANPGQTFRGPDMTIFYSSQLGT
`158 NP_001035086.1 LIKLPFISIWNAPTERCKS-RFGVELD---LS-VFDIVHNPNQTFMGDNITIFYSDKLGK
`159 XP_003502176.1 IKDQPFNIFWAAPTFFCQE-RFGVNMN---LQ-VFGIIPNPLETQSGSTIAIFYPDELGY
`160 XP_003257149.1 LPNRPFTTVWNANTQWCLE-RHGVDVD---VS-VFDVVANPGQTFRGPDMTIFYSSQLGT
`161 XP_002813766.6 LPNRPFTTVWNANTQWCLE-RHGVDVD---VS-VFDVVVNPGQTFRGPDMTIFYSSQLGT
`162 NP_001017941.1 VPNQPFTTIWNANTEWCMK-KHGVDVD---IS-IFDVVTNPGQTFRGPNMTIFYSSQLGT
`163 XP_002920567.1 VPNQPFTTIWNANTQWCLE-KYGVDVD---VS-VFDVVANPGQTFRGPDMTIFYSYQLGT
`164 XP_003476738.1 VPNQPFITVWNADTQRCLK-NYSVDVD---VS-VFDVVANPGQTFFGPNMTIFYSSKLGT
`165 NP_999606.1 VLNRPFTTIWNANTQWCLK-RHGVDVD---VS-VFEVVVNPGQTFRGPNMTIFYSSQLGT
`166 XP_002713406.3 VPPKPFTTVWNADTQWCLE-MHGVDVD---VS-VFDVVVNPRQAFRGPNVTIFYSSQLGT
`167 XP_003500449.1 VPNKPFITIWNADTYWCLK-NYGVDVD---VS-VFDVIANKEQSFQGPNVTIFYSWQLGT
`168 XP_001509131.1 VPNHPFTTIWNADTHTCLE-KFHVDVD---LD-VFDVVANPGEAFMGREMTIFYSNKLGL
`169 XP_001139800.4 IKSQPFNIFWAAPTMYCMP-FFNMAIN---LQ-VFNIISNPLETQSGSKIAIFYPNELGY
`170 NP_032343.3 VSNRPFITVWNGDTHWCLT-EYGVDVD---VS-VFDVVANKEQSFQGSNMTIFYREELGT
`171 NP_997499.2 VSNRPFITVWNADTHWCLK-DHGVDVD---VS-VFDVVANKEQNFQGPNMTIFYREELGT
`172 XP_001168796.1 LPNRPFTTVWNANTQWCLE-RHGVDVD---VS-VFDVVANPGQTFRGPDMTIFYSSQLGT
`173 NP_997482.2 VPELPFSVLWNVPSARCKT-RFGVHLP---LD-ALGIIANHGQRFHGQNITIFYKNQFGL
`174 NP_001193181.1 -PARPFSVLWNVPSARCKN-RFGVPLP---LE-ALGISANRGQHFHGQNVTIFYKNRLGF
`175 NP_001186958.1 VPERPFSVLWNVPSAHCEA-RFGVHLP---LN-ALGIIANRGQHFHGQNMTIFYKNQLGL
`176 NP_999604.1 -PERPFCVLWNVPSARCKA-RFGVHLP---LE-ALGITANHGQRFHGQNITIFYKSQLGL
`177 XP_001493753.3 -PECPFSVLWNVPSAHCKA-RFGVHLP---LE-ALGITANCGQRFHGQKITIFYKNQLGL
`178 NP_001121765.1 IGRRGFQVIWNVPTARCQR-RYGVSLP---LQ-QYNIIHNSHQRFQGQNMSIFYQRRLGL
`179 NP_821139.2 VPEHPFSVVWNVPSARCKA-HFGVHLP---LD-ALGIVANHGQHFHGQNISIFYKNQFGL
`180 XP_002128103.1 LPDRPFIGVWNVDSNRCLT-KYNVPID---LS-SFDIIHNPNEEYVGNQMVIFYAALLGL
`181 XP_003642042.3 ----PFAVLWNIPSSRCQR-RFGVGLP---LA-DYGIVENRGGRFAGQNITIFYKNKFGL
`182 : * * . : :: :*
`183
`184 NP_003108.2 YPYIDSITGVTVNGGIPQKISLQDHLDKAKKDITFYMPV-DNLGMAVIDWEEWRPTWARN
`185 XP_003318802.2 YPYIDSITGVTVNGGIPQKISLQDHLDKAKKDITFYMPV-DNLGMAVIDWEEWRPTWARN
`186 XP_003261317.2 YPYIDSITGVTVNGGIPQKISLQDHLDKAKQDITFYMPV-DNLGMAVIDWEEWRPTWARN
`187 XP_001086882.2 YPYIDLTTGVTVHGGIPQKVSLQDHLDKSKQDILFYMPV-DNLGMAVIDWEEWRPTWARN
`188 NP_001076141.2 YPHIDSK-NVSVHGGIPQLGPLQQHLDKAKKDILYYMPT-DNVGLAVIDWEEWRPTWLRN
`189 XP_002919069.1 YPHIDEKTGKNVNGGIPQSGNLKKHLEKAKKDIAYYIQT-DSIGLAVIDWENWRPIWVRN
`190 NP_999176.1 YPHVDENTGKNVNGGIPQLGSLQRHLDKAEKDILHYMQI-DKVGLSVIDWENWRPTWERN
`191 XP_002686960.3 YPKINERTGVHKNGGIPQVASLKKHLDKAEKDIAYYMPI-DNVGLAVIDWENWRPTWVRN
`192 NP_001008413.3 YPHIDEKTGKTVFGGIPQLGNLKSHLEKAKNDIAYYIPN-DSVGLAVIDWENWRPTWARN
`193 XP_003502178.1 YPHIDDS-NKSIHGGVPQLGSLKSHLEKARDDIQYYMPI-DNVGLAVIDWEDWRPTWSRN
`194 NP_001166492.1 YPYIDPHTGAIVHGGLPQLMNLQQHLRKSRQDILFYMPT-DSVGLAVIDWEEWRPTWTRN
`195 NP_001019492.1 YPHIDEM-HTAFHGGIPQLGSLKSHLEIAKGDIHHYMPI-DNVGLAVIDWEDWRPTWSRN
`196 XP_001507937.2 YPYIDEVTGKSVNTGLPQLCPLDLHLTKAKEDIVNYMPSAEKSGLAVIDWENWRPLWIRN
`197 NP_001073344.1 YPHIDAN-QAEHYGGIPQRGDYQAHLRKAKTDIEHYIPD-DKLGLAIIDWEEWRPTWLRN
`198 XP_003502177.1 YPHLDTK-LAEHHGGIPQLGNLKNHLDKSKTDIEHYIPV-DKFGLAVIDWEEWRPTWMRN
`
`59
`77
`57
`88
`71
`77
`57
`49
`75
`71
`74
`71
`93
`71
`83
`71
`71
`57
`59
`74
`74
`74
`58
`74
`77
`56
`58
`57
`57
`77
`57
`57
`77
`56
`56
`57
`58
`56
`56
`77
`79
`54
`72
`54
`54
`56
`55
`93
`51
`
`157
`157
`157
`157
`156
`157
`157
`155
`158
`156
`156
`156
`154
`156
`157
`
`Petitioner Merck, Ex. 1057, p. 3
`
`
`
`199 XP_002190553.4 YPYKNEITGEAFNGGLPQLSLLENHLKKAREDIQFYIPSDEQLGLAVIDWENWRPVWIRN
`200 XP_002932242.3 YPSINETNGKITNGGIPQLTNMDFHLKKVKEDIEYYLPYSKQNGLAVIDWEDWRPIWIRN
`201 NP_001082194.1 YPSINETNGKISKGGIPQLTNMAFHLKKAKEDIEYYLPSSKQHGLAVIDWEEWRPLYTRN
`202 XP_002919077.1 YPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARN
`203 XP_002712114.1 YPWYTSE-GVPINGGLPQNISLQVHLEKADQDINYYIPAKDFSGLAVIDWEYWRPQWARN
`204 XP_532444.4 YPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPAEDFNGLAVIDWEYWRPQWARN
`205 XP_002818436.2 YPWYTSQ-GVPINGGLPQNISLQAHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARN
`206 NP_084124.1 YPWYTSE-GVPINGGLPQNTSLQVHLKKAAQDINYYIPSENFSGLAVIDWEYWRPQWARN
`207 XP_003134772.2 YPWYTAQ-GVPINGGLPQNISLQVHLEKADQDINYYIPSEDFSGLAVIDWEYWRPQWARN
`208 NP_036401.2 YPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARN
`209 XP_003261316.2 YPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPSEDFSGLAVIDWEYWRPQWARN
`210 XP_003407292.1 YPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARN
`211 XP_003586042.1 YPWYTPQ-GVPINGGLPQNISLQVHLEKADQDIRYYIPSEDFSGLAVIDWEYWRPQWARN
`212 NP_001094250.1 YPWYTSE-GVPINGGLPQNTSLQVHLEKAYQDINYYIPSENFSGLAVIDWEYWRPQWARN
`213 XP_003221368.2 YPWYTSQ-DVPVNGGLPQNFSLQTHLEKASEDINYYIPDEDFTGLAVIDWEHWRPQWERN
`214 XP_003475093.1 YPWYTSQ-GVPINGGLPQNTSLKVHLKKVDQDIKYYIPVKDFRGLAVIDWEYWRPQWDRN
`215 NP_001090796.1 YPYFTDE-GEPVNGGVPQNESLKKHLNKSEHDINRLIPNLDFKGLGVVDWENWRPQWDRN
`216 XP_003221369.1 YPYFNDN-GDSINGGIPQNQSIIKHLNKAKSDIDHFITMKKFQGLGVIDWENWRPQWDRN
`217 XP_003449274.1 YPHYTPH-GKAVFGGLPQNCSLDRHLFKAYQDINHFIPAEDFRGLAVIDWEFWRPQWSRN
`218 NP_001074140.1 YPYYTSS-ETPINGGLPQNQSLSKHLSKARADIDKLIPIKDFHGLGVIDWENWRPQWVRN
`219 XP_003217669.1 YPYYNAQ-KVAVNGGVPQNSSLEEHLARLAVSISRYIRSEIKEGLAVIDWEEWRPIWIRN
`220 XP_001507903.3 YPWYNAQ-EDPINGGLPQNASLQTHLIKANQDIRHYISAEDFRGLAMIEWEYWRPQWSCN
`221 XP_003449275.2 YPYYSNS-GIPINGGLPQNQSISKHLGKARSDIDKLIPHKDFRGLGVIDWENWRPQWVRN
`222 XP_001378617.3 YPYHDSH-LRPVHGGVPQNSSLMEHLERLPEGVRHYIRSPDREGLAVIDWEDWRPVWIRN
`223 XP_003210019.2 YPYYNKR-WEPVNGGVPQQSSLAEHLARLQEGIGKYIRSATSEGLAVIDWEEWRPIWMRN
`224 XP_414258.3 YPYYNKQ-GKPVNGGVPQKSSLAEHLARLQENIGKYIRSATSEGLAVIDWEEWRPIWMRN
`225 NP_001080777.1 YPYYDEH-GAPVSGGLPQNASLRAHLDKLPDGIQKYIRSRDKDGLAVIDWEEWRPIWVRN
`226 NP_001119986.1 YPYYDEH-LAPVAGGLPQNASLRAHLDKLPEGIQKYIRSRDKDGLAVIDWEEWRPIWVRN
`227 XP_003221370.3 YPHFNDS-GDSVNGGIPQKESIIMHLIKASLDIDHSITMKTFQGLGVIDWENWRPQWDRA
`228 XP_003448364.1 YPYFEQD-ETPVNGGLPQVASRTRHLEKMPEDVKKYIRSEWATGLAVIDWEDWRPLWIRN
`229 XP_002189602.4 FPYYTSG-GVPVNGGLPQNASLEAHIQQATQDIKVTLHSPDYSGLAVIDWEKWRPLWIRN
`230 NP_001074154.2 FPYVDLHSMKEYNGGIPQRGNLSASLEKAKEEFLQFIPD-SSSGLAVMDWEEWLPIFDRN
`231 XP_003448436.2 YPRYSHQ-GEAINGGVPQNSSLDKHLKVARENVNTYIPDRGFPGLGVVDWESWRPEWERN
`232 XP_002813763.3 YPRFDSA-GRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESVGLAVIDWEDWRPVWVRN
`233 XP_002935681.1 YPYYDES-LSPVNGGLPQNNSLRDHLDKAFMDLLETISHPGFNGVAVVDWESWRPLWARN
`234 XP_001168599.1 YPRFDSA-GRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRN
`235 XP_687640.2 YPYFKPD-STPVYGGLPQAASLTQHLEKMPDGLKKYIKDQAVKGLAVIDWEEWRPLWIRN
`236 NP_003764.3 YPRFDSA-GRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRN
`237 XP_003476739.1 YPHFNEA-GMSVHGGVPQNGSLQEHLGMLRKPVEHYIRTREPAGLAIIDWEHWRPVWVRN
`238 XP_003257153.1 YPRFDSA-GRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRN
`239 XP_002758427.1 YPRFDSA-GRSVHGGVPQNGSLWAHLEMLRDHVEHYIRTPEPAGLAVIDWEDWRPVWVRN
`240 XP_001102414.2 YPYYTPT-GEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFN
`241 NP_742037.2 YPRFDAA-GMSVHGGVPQNGSLCAHLPMLKEAVERYIQTQEPAGLAVIDWEEWRPVWVRN
`242 NP_999605.1 YPHFDSV-GRSVHGGVPQNGSLWVHLKMLKGHVEHYIRTQEPAGLAVIDWEDWRPVWVRN
`243 NP_001009754.1 YPHFNSV-GRSVHGGVPQNGSLWVHLEMLKGHVEHYIRTQEPAGLAVIDWEDWRPVWVRN
`244 NP_083196.2 YPYFSED-GTSFYGGIPQKVNLSEHLRKSAGDIADAVTLWRSEGLAVIDWEGWRPQWDRN
`245 NP_001019491.1 YPYFSED-GISFYGGIPQNVNLSEHLRKSANDIANAVSLWRSEGLAVIDWEGWRPQWDRN
`246 NP_776772.1 YPHFNSV-GRSVHGGVPQNGSLWVHLEMLKGHVEHYIRTQEPAGLAVIDWEDWRPVWVRN
`247 NP_149349.2 YPYYTPT-GEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFN
`248 NP_001035086.1 YPHYGPN-DEPIYGGVPQNASLNEHLKKADEDLRKNIPDPEFQGLAIIDWEKWRPLWERN
`249 XP_003502176.1 YPYFSED-RRSIYGGIPQKGNLSEHLKKSASDIADTVTWWRSEGLAVIDWEGWKPQWDRN
`250 XP_003257149.1 YPYYTPT-GEPVFGGLPQNASLIAHLARTFQDILAAIPAPEFSGLAVIDWEAWRPRWAFN
`251 XP_002813766.6 YPYYTPS-GEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFN
`252 NP_001017941.1 YPYYTSA-GEPVFGGLPQNASLNAHLARTFQDILAAMPEPRFSGLAVIDWEAWRPRWAFN
`253 XP_002920567.1 YPYYTSA-GEPVFGGLPQNASLDTHLAHSFQDILAAIPASDFSGLAVIDWEAWRPRWAFN
`254 XP_003476738.1 YPYYTTT-GEPVFGGLPQNASLGEHLAYAFHDIQATMPAPDFSGLVVIDWEAWRPRWAFN
`255 NP_999606.1 YPYYTSA-GEPVFGGLPQNASLDVHLNRTFKDILAAMPESNFSGLAVIDWEAWRPRWAFN
`256 XP_002713406.3 YPYYTPA-GEPVFGGLPQNASLATHLARTFHDILAAMPAPDFSGLVVIDWEAWRPRWAFN
`257 XP_003500449.1 YPYYTST-GEPIFGGLPQNASLVTHLACTFQDIKAVMPEPDFSGLAVIDWEAWRPRWAFN
`258 XP_001509131.1 YPSYTSS-GQPLHGGLPQNASLATHLAQAQLDIQAAIPKSNYWGLAVIDWESWRPLWALN
`259 XP_001139800.4 YPYLSQD-GKSFNGGIPQNVSLSEHLRKTADDIGEGVPWWRSEELVVIDWESWKPQWDRN
`260 NP_032343.3 YPYYTPT-GEPVFGGLPQNASLVTHLAHTFQDIKAAMPEPDFSGLAVIDWEAWRPRWAFN
`261 NP_997499.2 YPYYTPT-GEPVFGGLPQNASLVTHLAHAFQDIKAAMPEPDFSGLAVIDWEAWRPRWAFN
`262 XP_001168796.1 YPYYTPT-GEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFN
`263 NP_997482.2 YPYFGPR-GTAHNGGIPQAVSLDHHLAQAAHQILHNLG-SSFAGLAVLDWEEWYPLWAGN
`264 NP_001193181.1 YPYLGPR-GTVHNGGIPQAVPLGCHLARAAHQIRHSLW-PGFAGLAVLDWEEWCPLWAGN
`
`139
`150
`145
`156
`116
`134
`116
`116
`134
`116
`156
`137
`134
`146
`116
`143
`116
`116
`117
`116
`116
`137
`117
`118
`118
`136
`116
`147
`130
`136
`116
`108
`134
`130
`133
`130
`152
`130
`142
`130
`130
`116
`118
`133
`133
`133
`117
`133
`136
`115
`117
`116
`116
`136
`116
`116
`136
`115
`115
`116
`117
`115
`115
`136
`137
`112
`
`Petitioner Merck, Ex. 1057, p. 4
`
`
`
`265 NP_001186958.1 YPYFGPR-GTAHNGGIPQALPLDRHLALAAYQIHHSLR-PGFAGPAVLDWEEWCPLWAGN
`266 NP_999604.1 YPYFGPR-GTAHNGGIPQAVSLDHHLARAAYQIHRSLR-PGFTGLAVLDWEEWCPLWAGN
`267 XP_001493753.3 YPYLGPR-GTAHNGGIPQAVPLDCHLARAAYQIHHSLR-PGFTGLAVLDWEEWSPLWAGN
`268 NP_001121765.1 YPYISRE-GVKVNGGLPQEGYLKAHLSLAGVEIREKLR-SSFSGLAVLDWEAWEPVWKWN
`269 NP_821139.2 YPYFGPR-GTAHNGGIPQAVSLDHHLARAAHQILHSLG-SSFAGLAVLDWEEWYPLWAGN
`270 XP_002128103.1 YPKYGTD-GLAVNGGIPQNGNISAHYEKCVDDIMARIPDSNYNGIAVIDWEAWRPKWERN
`271 XP_003642042.3 YPYISPQ-GVPHNGGIPQRAPLRAHLARVAGDVRLRLR-PAFSGLAVVDWEEWRPLWARN
`272 :* *:** . : :::** * * :
`273
`274 NP_003108.2 -WKP-KDVYKNRSIELVQQQNVQLSLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHL
`275 XP_003318802.2 -WKP-KDVYKNRSIELVQQQNVQLSLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHL
`276 XP_003261317.2 -WKP-KDVYKNRSIELVQQQNVQLSLAEATEKAKQEFEKAGKDFMVETIKLGKLLRPNHL
`277 XP_001086882.2 -WKP-KDVYKNRSIELVQQQNVQLSLPQATDKAKQEFEKAGKDFMLETIKLGRSLRPNHL
`278 NP_001076141.2 -WKP-KDIYRIKSIELVQQQNPQINLTEATKLAKIEFEKAGKCFMEETLKLGRLFRPNHF
`279 XP_002919069.1 -WKP-KDIYKHQSIELVQQHHIELNVTEATKIAKADFEKAGKCFMQETLKLGKSLRPNYL
`280 NP_999176.1 -WKE-KAIYRRQSIELVQQKNIKLTPAAATKLAKREFEKAGKTFMQETLKLGKLLRPNHL
`281 XP_002686960.3 -WKP-KDVYKKASIELVLQQNRHFTLKEATKRAKADFEKAAKSFMQETLKLGKFLRPNHL
`282 NP_001008413.3 -WKP-KDVYRDESVELVLQKNPQLSFPEASKIAKVDFETAGKSFMQETLKLGKLLRPNHL
`283 XP_003502178.1 -WKP-KDIYKHKSIELVKQQNKQLNITEATRRAKKDFEQAARSFMEGTLKLGKSLRPNHL
`284 NP_001166492.1 -WRP-KDIYRNKSIELVKSQHPQYNHSYAVAVAKRDFERTGKAFMLETLKLGKSLRPSSL
`285 NP_001019492.1 -WKF-KDIYRNKSIEFVQQQNTQLNLTEAVKRAKQEFEEAARNFMEQTLKLGKLLRPNHL
`286 XP_001507937.2 -WKP-KDIYRNRSIELVQQKDVTLNFSEAWNIAKVDFEKAARNFMQQSLKLGKTLRPNRL
`287 NP_001073344.1 -WKP-KDNYRNKSIELVQSTNPGLSITEATQKAIQQFEEAGRKFMEGTLHLGKFLRPNQL
`288 XP_003502177.1 -WKP-KDVYRNKSIALVQANNAGISIEDATQKAKDEFETAGRHFMEETLKLGKSVRPRHL
`289 XP_002190553.4 -WGS-KDIYRQESIELVQQRDLSISEAESRTIAKMEFEFAAKSFMLETLKLGIETKPNRL
`290 XP_002932242.3 -WAS-KAVYKMNSIEFARQMDITMTHKKAALIAEAQFESAAQNFMLQTLRLGKAMRPNYL
`291 NP_001082194.1 -WAS-KAVYKKQSIEFAQQMDITMTHKKAVGIAAAQFESAAKNLMLETLKLGKTMRPNYL
`292 XP_002919077.1 -WNT-KDVYRQKSRKLISDMQENISATDIEDLAKETFEESAKAFMKETIELGMKSRPKGL
`293 XP_002712114.1 -WNT-KDVYRQKSRKLISDMQANVSATDIEYLAKATFEESAKAFMKETLKLGIKSRPKGL
`294 XP_532444.4 -WNT-KDVYRQKSRKLISDMQENVSATDIEYLAKATFEESAKAFMKETIELGIKSRPKGL
`295 XP_002818436.2 -WNA-KDVYRQKSRKLISDMGKNVSATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGL
`296 NP_084124.1 -WNT-KDIYRQKSRTLISDMKENISAADIEYSAKATFEKSAKAFMEETIKLGSKSRPKGL
`297 XP_003134772.2 -WNT-KDVYRQKSRKLISELQENVSMADIEYLAKTTFEESAKAFMKETIELGIKSRPKGL
`298 NP_036401.2 -WNS-KDVYRQKSRKLISDMGKNVSATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGL
`299 XP_003261316.2 -WNA-KDVYRQKSRKLISDMGRNVSATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGL
`300 XP_003407292.1 -WNA-KNVYRQKSRKLISETQENVSATDIEYLAKATFEESAKAFMKETIKLGIKSRPKGL
`301 XP_003586042.1 -WNT-KDIYRQKSRKLISETQENASAADIEYLAKATFEESAKAFMKETIELGIKSRPKGL
`302 NP_001094250.1 -WNT-KDIYRQKSRTLISDMKENISTADIEYLAKATFEKSAKAFMEETIKLGIKSRPKGF
`303 XP_003221368.2 -WNT-KNIYRRQSRKLISAMQQNVSTNALEHLAKFSFEQCAKAFMKETIELGIKSRPKGL
`304 XP_003475093.1 -WNA-KDVYRRKSKELIFDLQQNVKASDIEYLAKATFEESAKAFMIETIKLGIKRRPKGL
`305 NP_001090796.1 -WGS-KLIYRNKSIELVKNHHPTWSDEQLKKKAKEEFDNAAKEFMTKTIALAQEKRSKGL
`306 XP_003221369.1 -WGN-KTIYKNKSLELVRKRHPHWPKNAVHKAAKEEFENAGKNFMNSTLSLAENMRPSGL
`307 XP_003449274.1 -WHK-KDIYRRKSKELTKKAYINVTAAQVEELARRRFEKSAKIFMLKTIQLGRQLRPSAL
`308 NP_001074140.1 -WGS-KDIYRNKSKELIRKLHPGWPQSKVENEAKEVFERAGQVFMNSTLLLAESRRPHGL
`309 XP_003217669.1 -WQP-KDIYRIASRQLVLSRHVELSEDQVKKKAQYEFESSASSFMKETLRVAKSFRPQQL
`310 XP_001507903.3 -WNA-KDVYRRNSRQLISERLRNLSDNSLEHSAKVSFEESAKAFMKETIELGMRNRPRAL
`311 XP_003449275.2 -WGS-KDIYRKRSREQIRKLHPNWPESKVEKEAKEGFERAGQAFMNLTLALAQGRRPGGL
`312 XP_001378617.3 -WQS-KDVYRKVSRQLVSLRHPTWSQEQVGKQAQYEFEFAARQFMLETLRWAKETRPRQL
`313 XP_003210019.2 -WKP-KDVYQEVSRELVKQKQPFWSPEEVNKQAVFEFESAARQFMVRTLRYAKSFRPKQL
`314 XP_414258.3 -WKP-KDVYQEVSRELVEQRQPFWSPEKVNKQAVFEFESAARHFMVTTLRYAKSFRPKQL
`315 NP_001080777.1 -WQN-KNVYRNNSRNLVASRHPSWPREQVEKEALYDFENAAREFMMETLRHAKNYRPRQL
`316 NP_001119986.1 -WQN-KDVYRQNSRNLVSSRHPTWPREKVDKEALYEFENAAREFMTETLRHAKNYRPRQL
`317 XP_003221370.3 -WGR-KNIYRDASLELVRKRHPHWPEDAIKKTARKEFENAGRNFMTTTLSLVKKLRPNGL
`318 XP_003448364.1 -WEP-KHIYRRHSEELVRQKNPTWTSDRVKRVAQQEFEMSARLFMLDTLKQAKNLRPNQL
`319 XP_002189602.4 -WDS-MEIYRQKSEELVQQQHPQWPPKEVEEMAKQQFEKSACDFMNKTLWLGKSLRPSAY
`320 NP_001074154.2 -FDL-KKIYMELSINYTLEQNSSLSPQQAATEAKQQFQKEARRFMEETLKKGINLRPRYL
`321 XP_003448436.2 -WDT-KKIYQEGSKALVRSKHPDWSPKQVDDAARVEFNKAARNFMEETLKLGQAARPDGL
`322 XP_002813763.3 -WQD-KDVYRRSSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHL
`323 XP_002935681.1 -WDK-MRVYQQSSQDLVKEFYPHLPPDKVIELAKAEFETAARKLMQSTLELGRALRPKGL
`324 XP_001168599.1 -WQD-KDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHL
`325 XP_687640.2 -WGP-KLIYRDRSQRLVAEKNPTWPLDQVTKVAQQEFELSARKFMLETLRLAKSLRPQQL
`326 NP_003764.3 -WQD-KDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHL
`327 XP_003476739.1 -WQD-KDVYRQWSRQLVASRHPDWPKDQIVKEAQYEFEFAARQFMLKTLHYVKSVRPQHL
`328 XP_003257153.1 -WQE-KDVYRRSSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHL
`329 XP_002758427.1 -WQD-KDVYRRSSRQLVASRHPDWQADRVVKQAQYEFECAARQFMLETLRYVKAVRPRHL
`330 XP_001102414.2 -WDT-KDIYRQRSRALVQAQHPDWPVTQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`
`130
`112
`112
`114
`113
`152
`109
`
`215
`215
`215
`215
`214
`215
`215
`213
`216
`214
`214
`214
`212
`214
`215
`197
`208
`203
`214
`174
`192
`174
`174
`192
`174
`214
`195
`192
`204
`174
`201
`174
`174
`175
`174
`174
`195
`175
`176
`176
`194
`174
`205
`188
`194
`174
`166
`192
`188
`191
`188
`210
`188
`200
`188
`188
`174
`
`Petitioner Merck, Ex. 1057, p. 5
`
`
`
`331 NP_742037.2 -WQE-KDVYRQSSRQLVASRHPDWPSDRIVKQAQYEFEFAARQFMLNTLRYVKAVRPQHL
`332 NP_999605.1 -WQD-KDVYRRLSRQLVASRHPDWPPDRVVKQAQYEFEFAARQFMLETLRFVKAFRPQHL
`333 NP_001009754.1 -WQD-KDVYRRLSRQLVASHHPDWPPERIVKEAQYEFEFAARQFMLETLRFVKAFRPRHL
`334 NP_083196.2 -WGS-RMIYKNHSLAFTRHHHPDWAETKVRTAAQKEFENAGRSFMNVTLTLALEMRPKRL
`335 NP_001019491.1 -WGG-RIIYKNHSLAFTRHHHPDWAETKVRTVAQQEFENAGKSLMNVTLTLALEMRPKRL
`336 NP_776772.1 -WQD-KDVYRRLSRHLVAIRHPDWPPERVAKEAQYEFEFAARQFMLETLRFVKAFRPRHL
`337 NP_149349.2 -WDT-KDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`338 NP_001035086.1 -WDS-KEVYWKASRAIVKAKHPTWSPDQIETEAVKEFEASSMAFMVETLKLGRRERSGGL
`339 XP_003502176.1 -WGS-RIIYKNHSLAFTRHHHPDWSEAKVRTVAQQEFENAGRSFMNITLTLALEMRPKRL
`340 XP_003257149.1 -WDT-KDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`341 XP_002813766.6 -WDT-KDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`342 NP_001017941.1 -WDT-KDIYRQRSRALVQKQHPDWLAPRVEAAAQDQFEGAAEEWMAGTLKLGQALRPQGL
`343 XP_002920567.1 -WDT-KDIYRQRSRTLVQGQHPDWPAPWVEAAARDQFQEAARAWMAGTLKLGQALRPRGL
`344 XP_003476738.1 -WDT-KDIYRQRSQALIQAQHPDWPESQVKTVAKDQFQKAAQAWMAGTLQLGQALRPRGL
`345 NP_999606.1 -WDA-KDIYRQRSRALVQKQHPDWPAPWVEAAAQDQFQEAAQTWMAGTLKLGQTLRPHGL
`346 XP_002713406.3 -WDA-KDIYRQRSRALVRATHPDWPAPRVDQAAQDQFQGAAQAWMTDTLQLGRLLRPGGL
`347 XP_003500449.1 -WDS-KDIYRQRSVALVQAEHPDWPETLVEAVAQDQFQEAAQAWMAGTLQLGQILRPHGL
`348 XP_001509131.1 -WDS-KDVYRERSRALVREEHPDWSSWQVEEEAVIQFQTAARAWMSQTLQLGQTLRPRGL
`349 XP_001139800.4 -RGS-RIIYKNHSLAFTRNHHPYWSEMKVETVAQEEFENAGKNFMNITLTLALEMRPKCL
`350 NP_032343.3 -WDS-KDIYRQRSMELVQAEHPDWPETLVEAAAKNQFQEAAEAWMAGTLQLGQVLRPRGL
`351 NP_997499.2 -WDS-KDIYQQRSMELVRAEHPDWPETLVEAEAQDQFQEAAQAWMAGTLQLGQVLRPRGL
`352 XP_001168796.1 -WDT-KDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`353 NP_997482.2 -WGTHRQVYQAASWAWAQQMFPDLNPQEQLHKAQTGFEQAARALMEHTLRLGQMLRPHGL
`354 NP_001193181.1 -WGR-RQVYRAASWAWAQWVFPNLDPQEQLHKARVGFEQAARALMEDTLWLGRALQPQGL
`355 NP_001186958.1 -WGR-RRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARALMEDTLRVAQALRPHGL
`356 NP_999604.1 -WGR-RQAYQAASCAWAQRVYPNLDPQEQLCKARAGFEEAARALMEDTLRLGRMLRPHGL
`357 XP_001493753.3 -WGR-RRAYQTASWAWAQRVFPYLDPQEQLHKAQTGFEQAARALMEDTLRLGQALQPYGL
`358 NP_001121765.1 -FGT-RIVYRKLSKKLVRWEHPDMSEEEVKSKAKLDFELAARQFMEETLRLGLRLCPEGL
`359 NP_821139.2 -WGPHRQVYLAASWVWTQQMFPGLDPQEQLHKAHTSFEQAARALMEYTLQLGRTLRPSGL
`360 XP_002128103.1 GWGS-GLIYQNKSIEKVKKEHPSWPLNKVKAQAKIEFEEAAKSYMLGTLNLARLMRPKAH
`361 XP_003642042.3 -WGR-KRVYQLASQRWAQERGR------GRRLARRAFERAARALMEQTLLLGRSLRPAGL
`362 * * * *: . : ::
`363
`364 NP_003108.2 WGYYLFPDCYNHHYKK----PGYNGSCFNVEIKRNDDLSWLWNESTALYPSIYLNTQQSP
`365 XP_003318802.2 WGYYLFPDCYNHHYKK----PGYNGSCFNVEIKRNDDLSWLWNESTALYPSIYLNTQQSP
`366 XP_003261317.2 WGYYLFPDCYNHHYKK----PGYNGSCFNVEIKRNDDLSWLWNESTALYPSIYLNTQQSP
`367 XP_001086882.2 WGYYLFPDCYNHHYRK----PGYNGSCFDVEIKRNDDLSWLWNESTALYPSIYLNTQQSV
`368 NP_001076141.2 WGYYLFPDCYNHNYDK----PNYKGICFDIEKKRNDDLDWLWKESTALFPSVYLKSSLQS
`369 XP_002919069.1 WGYYLFPDCYNHNYKK----PDYNGSCSDLEKKRNDELNWMWKESTALFPSIYLNTKLKS
`370 NP_999176.1 WGYYLFPDCYNHNYHK----PGYNGSCLDIEKRRNDALDWLWKESTALFPSIYLNTRLKP
`371 XP
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