Reference sequence (1): NP_003108.2
`Identities normalised by aligned length.
`Colored by: identity
`
` cov pid 1 [ . . . . : . . . 80
` 1 NP_003108.2 100.0% 100.0% MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLG-
` 2 XP_003318802.2 100.0% 96.3% MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLG-
` 3 XP_003261317.2 100.0% 93.3% MGVLKFKHIFFRSFVKSNGISQIVF-TF----------------LLIPRCLTLNFRAPPVIPNVPFLWAWNAPSEFCLG-
` 4 XP_001086882.2 100.0% 86.9% MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPIIPNVPFLWAWNAPSEFCLG-
` 5 NP_001076141.2 99.4% 67.1% MGVLKFKHIFFGSAVEFNRAFQILY-IF----------------LLIPCCLTANFRAPPVIPNVPFLWAWNAPTELCLG-
` 6 XP_002919069.1 94.7% 66.8% MAVLRFQRIFFRSFVGSRGATPVVL-TF----------------LLIPCCLTQEFRAPPFIPNVSFLWGWNAPTELCAQ-
` 7 NP_999176.1 94.5% 65.7% MGVQRLQHISFRSFFVPSGAPQVVF-TF----------------LLIPCCLALDFRASPIIPNTTFLWVWNAPTESCAK-
` 8 XP_002686960.3 94.1% 65.8% --MLRHQHISFRNFVGSNGAPQAVF-TF----------------LLVPCCLALNFTAPPLIPNIPFLWAWNAPTNHCAE-
` 9 NP_001008413.3 99.6% 61.1% MRMLRRHHISFRSFAGSSGTPQAVF-TF----------------LLLPCCLALDFRAPPLISNTSFLWAWNAPVERCVNR
`10 XP_003502178.1 94.5% 62.1% MRVLCLKHSFSGSFLESNGAPQTVL-VF----------------LLLPCCLTGDFRAPPLIPNVPFLWVWNAPTESCLT-
`11 NP_001166492.1 96.4% 59.2% MGAFTFKHSFFGSFVECSGVLQTVF-IF----------------LLIPCCLA-DKRAPPLIPNVPLLWVWNAPTEFCIG-
`12 NP_001019492.1 94.5% 61.1% MRVLCFKHSFFGSLLESSGLPQTLL-VF----------------LLIRCCLTVDFRAPPLIPNVPFLCAWNAPTESCAT-
`13 XP_001507937.2 95.8% 57.3% ----RLPHLSSGSWAVCCQASWVAV-VL----------------QLLPWCMALDIQAPPMIPNLPFLSAWNAPTELCAQ-
`14 NP_001073344.1 94.9% 57.8% MGELRFKHLFWGSFVESGGTFQTVL-IF----------------LLIPCSLTVDYRAAPILSNTTFLWIWNVPTERCVG-
`15 XP_003502177.1 94.9% 55.0% MGGLPLKHLFWGSFVVSRATFQTVLIIF----------------LLIPCSLTVDYRGGPLLPSEILIWVWNVPTEACIG-
`16 XP_002190553.4 90.1% 54.0% -------------------ASGVVF-AT----------------LLVSCCSSLNIRARPLLSNSPFLSIWNAPTELCTE-
`17 XP_002932242.3 91.9% 45.6% MERVNCEHILYKKLL--------CILCS----------------FLIHTCQSMDMKAPTNGP-ANFMAIWNAPTELCMR-
`18 NP_001082194.1 90.9% 45.4% -----FQHVLCKKCI--------CILLF----------------CFITSCQSMDIKAPTNGL-SNFMAIWNAPTELCLQ-
`19 XP_002919077.1 90.5% 43.8% MKVLSEGQLRFCVVQPIHLTSC--LVIF----------------IILKSISSLKPARLPIYQRKPFIAAWNAPTDQCLI-
`20 XP_002712114.1 82.6% 47.0% ----------------------------------------------------------PIYQRKPFIAAWNAPTDQCLM-
`21 XP_532444.4 86.1% 44.6% ------------------------LLIF----------------FILKSISSLKPARLPIYQRKPFIAAWNAPTDQCLI-
`22 XP_002818436.2 82.6% 46.5% ----------------------------------------------------------PIYQRKPFIAAWNAPTDQCLI-
`23 NP_084124.1 81.2% 45.1% ----------------------------------------------------------PVYQRKPFIAAWNAPTDLCLI-
`24 XP_003134772.2 86.1% 43.9% ------------------------LLIF----------------FILKSISSLKPARLPVYQRKPFIAAWNAPTDQCLI-
`25 NP_036401.2 82.6% 46.5% ----------------------------------------------------------PIYQRKPFIAAWNAPTDQCLI-
`26 XP_003261316.2 90.5% 43.8% MKVLSEGHLRLCVVQPVHLTSW--LLIF----------------FILKSISCLKPAQLPIYQRKPFIAAWNAPTDQCLI-
`27 XP_003407292.1 86.5% 44.4% -------------------SSW--LLIF----------------FILKSISSLKPARLPIYQRKPFIAAWNAPTDQCLI-
`28 XP_003586042.1 86.1% 43.9% ------------------------LFIL----------------FILKSISSLKPARLPVYQRKPFIAAWNAPTDQCLI-
`29 NP_001094250.1 87.1% 40.5% ----------RCVVQPVHLTSG--LLIF----------------FILKSISSLKPARLPVYQRKPFIAAWNAPTDLCLI-
`30 XP_003221368.2 82.4% 45.7% ----------------------------------------------------------PISRRKPFIAAWNAPTDHCSI-
`31 XP_003475093.1 88.3% 41.2% -------------IQSIHLTPW--LLVF----------------LSLKSVCSLKPARLPLYQRKPFIAAWNTPTDQCLM-
`32 NP_001090796.1 79.6% 45.4% ----------------------------------------------------------PFIQNKPFLAVWNAPTEQCKQ-
`33 XP_003221369.1 80.0% 44.6% ----------------------------------------------------------PLFPNKAFVVVWNAPTEQCRL-
`34 XP_003449274.1 83.2% 40.1% ----------------------------------------------------------PLIGRKPFIAAWNAPLDLCTF-
`35 NP_001074140.1 79.8% 44.6% ----------------------------------------------------------PLLPHRPFVVVWNAPTESCRL-
`36 XP_003217669.1 81.6% 43.6% ----------------------------------------------------------PIFTRRPFIVAWNVPSQDCQP-
`37 XP_001507903.3 83.8% 41.8% -------------------LSW--LLIS----------------FLLELTSSLKPAQHPIFQKKPFVAVWNAPTDQCLF-
`38 XP_003449275.2 80.0% 44.0% ---------------------------------------------------------PPLIPHKPFVVVWNAPTESCRL-
`39 XP_001378617.3 80.2% 44.1% --------------------------------------------------------APPIFTRRPFLVAWNAPTQDCWP-
`40 XP_003210019.2 82.0% 44.5% --------------------------------------------------------AAPLLTRRPFLVAWNAPTQDCKP-
`41 XP_414258.3 84.6% 42.5% ---------------------------LVPA-----------VLAVLARQSPEKPSAAPLLTRRPFLVAWNAPTQDCKP-
`42 NP_001080777.1 79.8% 44.9% ----------------------------------------------------------PVFTRRPFIIAWNAPTQDCPP-
`43 NP_001119986.1 83.0% 42.0% -------------------------LSFLPA--FLWLFLGAAANGQLSDSWLNKPTFRPVFTRRPFIIAWNAPTQDCPP-
`44 XP_003221370.3 82.8% 41.7% --------------------------------------------FMLVDGSTAMPTRAPLFSKKAFVVVWNAPTEQCRL-
`45 XP_003448364.1 81.4% 40.9% ---------------------------LLIV--PLWDCL---------FALGLKPTRWPLYSRKPLLLAWNAPIEDCAP-
`46 XP_002189602.4 78.8% 43.7% ----------------------------------------------------------PVLVNRPFVTIWNIPTERCAE-
`47 NP_001074154.2 79.4% 42.8% ----------------------------------------------------------------PFVLLWNAPISKCHQ-
`48 XP_003448436.2 83.6% 39.9% ----------------------------VL---LHL--------ILISLVSGLHYPNSP-FSKVPFLTVWNAPSANCLS-
`49 XP_002813763.3 82.4% 37.9% -----------------------------LA--VAW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`50 XP_002935681.1 81.2% 42.2% ---------------------------------YTF--------LLSGLLGWLAAGTDPVLKGRPFASVWNAPTSPCLD-
`51 XP_001168599.1 82.4% 37.9% -----------------------------LA--VAW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`52 XP_687640.2 86.7% 37.4% ---------HLSGTTRTQRASW--LQVLLLM--LFWTCL---------KAQQLKNTRWPLYSGKPLLLAWNAPTEDCRP-
`53 NP_003764.3 82.4% 37.7% -----------------------------LA--VSW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`54 XP_003476739.1 83.2% 37.1% -----------AGLGPI----V--TLALVLP--VAW-------------AMELKPTGPPIFTGRPFVVAWDVPTQDCGP-
`55 XP_003257153.1 82.4% 37.7% -----------------------------LA--VAW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`56 XP_002758427.1 81.6% 38.1% -----------------------------LV--VAW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`57 XP_001102414.2 80.8% 40.2% ----------------------------------------------------------PLLPNRPFATVWNANTQWCLE-
`58 NP_742037.2 80.2% 40.6% --------------------------------------------------------APPIFTGRPFVVAWNVPTQECAP-
`59 NP_999605.1 81.6% 38.5% -----------------------------LA--VAW-------------ATELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`60 NP_001009754.1 81.6% 38.5% -----------------------------LV--VAW-------------ATELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`61 NP_083196.2 82.4% 39.5% ---------------------------------VLF--------VLLVAPAALKPAMPPVIKDHPFNVFWAAPTLFCKD-
`62 NP_001019491.1 79.8% 41.3% ---------------------------------------------------------PPVIKNQPFNIFWAAPTLFCKD-
`63 NP_776772.1 81.6% 38.3% -----------------------------LV--VAW-------------ATELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`64 NP_149349.2 82.0% 39.0% ---------------------------LLP---ICA--------LFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLE-
`65 NP_001035086.1 79.4% 40.6% ----------------------------------------------------------P-LIKLPFISIWNAPTERCKS-
`66 XP_003502176.1 85.3% 37.9% ---------------------------------------------------------PPVIKDQPFNIFWAAPTFFCQE-
`67 XP_003257149.1 80.8% 39.5% ----------------------------------------------------------PLLPNRPFTTVWNANTQWCLE-
`68 XP_002813766.6 80.8% 40.0% ----------------------------------------------------------PLLPNRPFTTVWNANTQWCLE-
`69 NP_001017941.1 82.0% 38.5% ---------------------------LLP---VCT--------LFLNLLSMTQGSRDPVVPNQPFTTIWNANTEWCMK-
`
`Petitioner Merck, Ex. 1058, p. 1
`
`
`Identities normalised by aligned length.
`Colored by: identity
`
` cov pid 1 [ . . . . : . . . 80
` 1 NP_003108.2 100.0% 100.0% MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLG-
` 2 XP_003318802.2 100.0% 96.3% MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLG-
` 3 XP_003261317.2 100.0% 93.3% MGVLKFKHIFFRSFVKSNGISQIVF-TF----------------LLIPRCLTLNFRAPPVIPNVPFLWAWNAPSEFCLG-
` 4 XP_001086882.2 100.0% 86.9% MGVLKFKHIFFRSFVKSSGVSQIVF-TF----------------LLIPCCLTLNFRAPPIIPNVPFLWAWNAPSEFCLG-
` 5 NP_001076141.2 99.4% 67.1% MGVLKFKHIFFGSAVEFNRAFQILY-IF----------------LLIPCCLTANFRAPPVIPNVPFLWAWNAPTELCLG-
` 6 XP_002919069.1 94.7% 66.8% MAVLRFQRIFFRSFVGSRGATPVVL-TF----------------LLIPCCLTQEFRAPPFIPNVSFLWGWNAPTELCAQ-
` 7 NP_999176.1 94.5% 65.7% MGVQRLQHISFRSFFVPSGAPQVVF-TF----------------LLIPCCLALDFRASPIIPNTTFLWVWNAPTESCAK-
` 8 XP_002686960.3 94.1% 65.8% --MLRHQHISFRNFVGSNGAPQAVF-TF----------------LLVPCCLALNFTAPPLIPNIPFLWAWNAPTNHCAE-
` 9 NP_001008413.3 99.6% 61.1% MRMLRRHHISFRSFAGSSGTPQAVF-TF----------------LLLPCCLALDFRAPPLISNTSFLWAWNAPVERCVNR
`10 XP_003502178.1 94.5% 62.1% MRVLCLKHSFSGSFLESNGAPQTVL-VF----------------LLLPCCLTGDFRAPPLIPNVPFLWVWNAPTESCLT-
`11 NP_001166492.1 96.4% 59.2% MGAFTFKHSFFGSFVECSGVLQTVF-IF----------------LLIPCCLA-DKRAPPLIPNVPLLWVWNAPTEFCIG-
`12 NP_001019492.1 94.5% 61.1% MRVLCFKHSFFGSLLESSGLPQTLL-VF----------------LLIRCCLTVDFRAPPLIPNVPFLCAWNAPTESCAT-
`13 XP_001507937.2 95.8% 57.3% ----RLPHLSSGSWAVCCQASWVAV-VL----------------QLLPWCMALDIQAPPMIPNLPFLSAWNAPTELCAQ-
`14 NP_001073344.1 94.9% 57.8% MGELRFKHLFWGSFVESGGTFQTVL-IF----------------LLIPCSLTVDYRAAPILSNTTFLWIWNVPTERCVG-
`15 XP_003502177.1 94.9% 55.0% MGGLPLKHLFWGSFVVSRATFQTVLIIF----------------LLIPCSLTVDYRGGPLLPSEILIWVWNVPTEACIG-
`16 XP_002190553.4 90.1% 54.0% -------------------ASGVVF-AT----------------LLVSCCSSLNIRARPLLSNSPFLSIWNAPTELCTE-
`17 XP_002932242.3 91.9% 45.6% MERVNCEHILYKKLL--------CILCS----------------FLIHTCQSMDMKAPTNGP-ANFMAIWNAPTELCMR-
`18 NP_001082194.1 90.9% 45.4% -----FQHVLCKKCI--------CILLF----------------CFITSCQSMDIKAPTNGL-SNFMAIWNAPTELCLQ-
`19 XP_002919077.1 90.5% 43.8% MKVLSEGQLRFCVVQPIHLTSC--LVIF----------------IILKSISSLKPARLPIYQRKPFIAAWNAPTDQCLI-
`20 XP_002712114.1 82.6% 47.0% ----------------------------------------------------------PIYQRKPFIAAWNAPTDQCLM-
`21 XP_532444.4 86.1% 44.6% ------------------------LLIF----------------FILKSISSLKPARLPIYQRKPFIAAWNAPTDQCLI-
`22 XP_002818436.2 82.6% 46.5% ----------------------------------------------------------PIYQRKPFIAAWNAPTDQCLI-
`23 NP_084124.1 81.2% 45.1% ----------------------------------------------------------PVYQRKPFIAAWNAPTDLCLI-
`24 XP_003134772.2 86.1% 43.9% ------------------------LLIF----------------FILKSISSLKPARLPVYQRKPFIAAWNAPTDQCLI-
`25 NP_036401.2 82.6% 46.5% ----------------------------------------------------------PIYQRKPFIAAWNAPTDQCLI-
`26 XP_003261316.2 90.5% 43.8% MKVLSEGHLRLCVVQPVHLTSW--LLIF----------------FILKSISCLKPAQLPIYQRKPFIAAWNAPTDQCLI-
`27 XP_003407292.1 86.5% 44.4% -------------------SSW--LLIF----------------FILKSISSLKPARLPIYQRKPFIAAWNAPTDQCLI-
`28 XP_003586042.1 86.1% 43.9% ------------------------LFIL----------------FILKSISSLKPARLPVYQRKPFIAAWNAPTDQCLI-
`29 NP_001094250.1 87.1% 40.5% ----------RCVVQPVHLTSG--LLIF----------------FILKSISSLKPARLPVYQRKPFIAAWNAPTDLCLI-
`30 XP_003221368.2 82.4% 45.7% ----------------------------------------------------------PISRRKPFIAAWNAPTDHCSI-
`31 XP_003475093.1 88.3% 41.2% -------------IQSIHLTPW--LLVF----------------LSLKSVCSLKPARLPLYQRKPFIAAWNTPTDQCLM-
`32 NP_001090796.1 79.6% 45.4% ----------------------------------------------------------PFIQNKPFLAVWNAPTEQCKQ-
`33 XP_003221369.1 80.0% 44.6% ----------------------------------------------------------PLFPNKAFVVVWNAPTEQCRL-
`34 XP_003449274.1 83.2% 40.1% ----------------------------------------------------------PLIGRKPFIAAWNAPLDLCTF-
`35 NP_001074140.1 79.8% 44.6% ----------------------------------------------------------PLLPHRPFVVVWNAPTESCRL-
`36 XP_003217669.1 81.6% 43.6% ----------------------------------------------------------PIFTRRPFIVAWNVPSQDCQP-
`37 XP_001507903.3 83.8% 41.8% -------------------LSW--LLIS----------------FLLELTSSLKPAQHPIFQKKPFVAVWNAPTDQCLF-
`38 XP_003449275.2 80.0% 44.0% ---------------------------------------------------------PPLIPHKPFVVVWNAPTESCRL-
`39 XP_001378617.3 80.2% 44.1% --------------------------------------------------------APPIFTRRPFLVAWNAPTQDCWP-
`40 XP_003210019.2 82.0% 44.5% --------------------------------------------------------AAPLLTRRPFLVAWNAPTQDCKP-
`41 XP_414258.3 84.6% 42.5% ---------------------------LVPA-----------VLAVLARQSPEKPSAAPLLTRRPFLVAWNAPTQDCKP-
`42 NP_001080777.1 79.8% 44.9% ----------------------------------------------------------PVFTRRPFIIAWNAPTQDCPP-
`43 NP_001119986.1 83.0% 42.0% -------------------------LSFLPA--FLWLFLGAAANGQLSDSWLNKPTFRPVFTRRPFIIAWNAPTQDCPP-
`44 XP_003221370.3 82.8% 41.7% --------------------------------------------FMLVDGSTAMPTRAPLFSKKAFVVVWNAPTEQCRL-
`45 XP_003448364.1 81.4% 40.9% ---------------------------LLIV--PLWDCL---------FALGLKPTRWPLYSRKPLLLAWNAPIEDCAP-
`46 XP_002189602.4 78.8% 43.7% ----------------------------------------------------------PVLVNRPFVTIWNIPTERCAE-
`47 NP_001074154.2 79.4% 42.8% ----------------------------------------------------------------PFVLLWNAPISKCHQ-
`48 XP_003448436.2 83.6% 39.9% ----------------------------VL---LHL--------ILISLVSGLHYPNSP-FSKVPFLTVWNAPSANCLS-
`49 XP_002813763.3 82.4% 37.9% -----------------------------LA--VAW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`50 XP_002935681.1 81.2% 42.2% ---------------------------------YTF--------LLSGLLGWLAAGTDPVLKGRPFASVWNAPTSPCLD-
`51 XP_001168599.1 82.4% 37.9% -----------------------------LA--VAW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`52 XP_687640.2 86.7% 37.4% ---------HLSGTTRTQRASW--LQVLLLM--LFWTCL---------KAQQLKNTRWPLYSGKPLLLAWNAPTEDCRP-
`53 NP_003764.3 82.4% 37.7% -----------------------------LA--VSW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`54 XP_003476739.1 83.2% 37.1% -----------AGLGPI----V--TLALVLP--VAW-------------AMELKPTGPPIFTGRPFVVAWDVPTQDCGP-
`55 XP_003257153.1 82.4% 37.7% -----------------------------LA--VAW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`56 XP_002758427.1 81.6% 38.1% -----------------------------LV--VAW-------------AMELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`57 XP_001102414.2 80.8% 40.2% ----------------------------------------------------------PLLPNRPFATVWNANTQWCLE-
`58 NP_742037.2 80.2% 40.6% --------------------------------------------------------APPIFTGRPFVVAWNVPTQECAP-
`59 NP_999605.1 81.6% 38.5% -----------------------------LA--VAW-------------ATELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`60 NP_001009754.1 81.6% 38.5% -----------------------------LV--VAW-------------ATELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`61 NP_083196.2 82.4% 39.5% ---------------------------------VLF--------VLLVAPAALKPAMPPVIKDHPFNVFWAAPTLFCKD-
`62 NP_001019491.1 79.8% 41.3% ---------------------------------------------------------PPVIKNQPFNIFWAAPTLFCKD-
`63 NP_776772.1 81.6% 38.3% -----------------------------LV--VAW-------------ATELKPTAPPIFTGRPFVVAWDVPTQDCGP-
`64 NP_149349.2 82.0% 39.0% ---------------------------LLP---ICA--------LFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLE-
`65 NP_001035086.1 79.4% 40.6% ----------------------------------------------------------P-LIKLPFISIWNAPTERCKS-
`66 XP_003502176.1 85.3% 37.9% ---------------------------------------------------------PPVIKDQPFNIFWAAPTFFCQE-
`67 XP_003257149.1 80.8% 39.5% ----------------------------------------------------------PLLPNRPFTTVWNANTQWCLE-
`68 XP_002813766.6 80.8% 40.0% ----------------------------------------------------------PLLPNRPFTTVWNANTQWCLE-
`69 NP_001017941.1 82.0% 38.5% ---------------------------LLP---VCT--------LFLNLLSMTQGSRDPVVPNQPFTTIWNANTEWCMK-
`
`Petitioner Merck, Ex. 1058, p. 1
`
`
`
`70 XP_002920567.1 79.0% 40.7% ----------------------------------------------------------PMVPNQPFTTIWNANTQWCLE-
`71 XP_003476738.1 79.0% 40.9% ----------------------------------------------------------PVVPNQPFITVWNADTQRCLK-
`72 NP_999606.1 82.0% 38.8% ---------------------------LLP---ICT--------LFLNLLSVAQGSRDPVVLNRPFTTIWNANTQWCLK-
`73 XP_002713406.3 78.6% 40.0% -----------------------------------------------------------TVPPKPFTTVWNADTQWCLE-
`74 XP_003500449.1 79.2% 40.4% -----------------------------------------------------------TVPNKPFITIWNADTYWCLK-
`75 XP_001509131.1 79.0% 38.2% ----------------------------------------------------------PVVPNHPFTTIWNADTHTCLE-
`76 XP_001139800.4 79.8% 38.6% ---------------------------------------------------------PPVIKSQPFNIFWAAPTMYCMP-
`77 NP_032343.3 78.8% 39.6% -----------------------------------------------------------VVSNRPFITVWNGDTHWCLT-
`78 NP_997499.2 80.4% 38.3% -----------------------------------------------------------MVSNRPFITVWNADTHWCLK-
`79 XP_001168796.1 77.8% 35.4% ---------------------------LLP---ICA--------LFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLE-
`80 NP_997482.2 76.8% 36.7% ----------------ITQLGL--TLVV------------------GLTLCLVHVQALLQVPELPFSVLWNVPSARCKT-
`81 NP_001193181.1 77.8% 37.4% -------------------------------------------------------------PARPFSVLWNVPSARCKN-
`82 NP_001186958.1 79.4% 35.4% -------------------------LVL------------------GVALCLGCGQPLPQVPERPFSVLWNVPSAHCEA-
`83 NP_999604.1 71.9% 39.4% -------------------------------------------------------------PERPFCVLWNVPSARCKA-
`84 XP_001493753.3 71.9% 39.4% -------------------------------------------------------------PECPFSVLWNVPSAHCKA-
`85 NP_001121765.1 76.4% 38.0% -----------------------------------------------------------VIGRRGFQVIWNVPTARCQR-
`86 NP_821139.2 72.1% 38.6% ------------------------------------------------------------VPEHPFSVVWNVPSARCKA-
`87 XP_002128103.1 72.9% 35.4% -------------------MSF--SYVFLALGILGSVCHSQSLQS-YLTTSLKDNIWQPPLPDRPFIGVWNVDSNRCLT-
`88 XP_003642042.3 69.7% 37.2% ----------------------------------------------------------------PFAVLWNIPSSRCQR-
` consensus/100% .................................................................h..hWshs...C...
` consensus/90% ............................................................h.t.sF.hhWsssot.Ch..
` consensus/80% ..........................................................Phh.tpPFhhhWNsPop.Ch..
` consensus/70% ..........................................................PlhsppPFlssWNAPTp.Ch..
`
` cov pid 81 . 1 . . . . : . 160
` 1 NP_003108.2 100.0% 100.0% KFDEPLD---MS-LFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDHLDKAKKDITFYMPV-
` 2 XP_003318802.2 100.0% 96.3% KFDEPLD---MS-LFSFIGSPRINVTGQDVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDHLDKAKKDITFYMPV-
` 3 XP_003261317.2 100.0% 93.3% KFDEPLD---MS-LFSLTGSPRINVTGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDHLDKAKQDITFYMPV-
` 4 XP_001086882.2 100.0% 86.9% KFNEPLD---MS-LFTLMGSPRINITGQGVTIFYVDRLGYYPYIDLTTGVTVHGGIPQKVSLQDHLDKSKQDILFYMPV-
` 5 NP_001076141.2 99.4% 67.1% KSGEPLD---TS-LFSLFGSPSKDKTGQGITIFYVDRLGYYPHIDSK-NVSVHGGIPQLGPLQQHLDKAKKDILYYMPT-
` 6 XP_002919069.1 94.7% 66.8% KFNVQLD---LN-LFSLIGSPQKSATGQGITLFYANRLGYYPHIDEKTGKNVNGGIPQSGNLKKHLEKAKKDIAYYIQT-
` 7 NP_999176.1 94.5% 65.7% KFYMPPD---LS-LFSFVTSPRASVTGQFLTLFYANRLGYYPHVDENTGKNVNGGIPQLGSLQRHLDKAEKDILHYMQI-
` 8 XP_002686960.3 94.1% 65.8% IFSMPPD---LG-LFSLVGSPQKDVTGQPITLFYADRLGYYPKINERTGVHKNGGIPQVASLKKHLDKAEKDIAYYMPI-
` 9 NP_001008413.3 99.6% 61.1% RFQLPPD---LR-LFSVKGSPQKSATGQFITLFYADRLGYYPHIDEKTGKTVFGGIPQLGNLKSHLEKAKNDIAYYIPN-
`10 XP_003502178.1 94.5% 62.1% KFNEPLD---LS-LFSLVGSPKKSATGQPITIFYTDRLGFYPHIDDS-NKSIHGGVPQLGSLKSHLEKARDDIQYYMPI-
`11 NP_001166492.1 96.4% 59.2% GTNQPLD---MS-FFSIVGTPRKNITGQSITLYYVDRLGYYPYIDPHTGAIVHGGLPQLMNLQQHLRKSRQDILFYMPT-
`12 NP_001019492.1 94.5% 61.1% RFNQPLD---LS-LFSLVGSPRKTAIGHPVTIFYSDRLGLYPHIDEM-HTAFHGGIPQLGSLKSHLEIAKGDIHHYMPI-
`13 XP_001507937.2 95.8% 57.3% KHDVELD---MS-LFSLVGSTRQEIKGQNITLFYTDRLGYYPYIDEVTGKSVNTGLPQLCPLDLHLTKAKEDIVNYMPSA
`14 NP_001073344.1 94.9% 57.8% NVNDPID---LS-FFSLIGSPRKTATGQPVTLFYVDRLGLYPHIDAN-QAEHYGGIPQRGDYQAHLRKAKTDIEHYIPD-
`15 XP_003502177.1 94.9% 55.0% NFSHSID---LS-LFPIVGSPRKTATGQPVTLFYVDRLGYYPHLDTK-LAEHHGGIPQLGNLKNHLDKSKTDIEHYIPV-
`16 XP_002190553.4 90.1% 54.0% RTGVQLD---MN-FFPLIGSTLKTSVGQNITLFYPDRIGYYPYKNEITGEAFNGGLPQLSLLENHLKKAREDIQFYIPSD
`17 XP_002932242.3 91.9% 45.6% KFKVNID---IS-LFQITGSPESSTIAQNITIFYTDRLGYYPSINETNGKITNGGIPQLTNMDFHLKKVKEDIEYYLPYS
`18 NP_001082194.1 90.9% 45.4% KFKVKID---VS-LFQIVGTTFNSSIAQNITIFYTDRLGHYPSINETNGKISKGGIPQLTNMAFHLKKAKEDIEYYLPSS
`19 XP_002919077.1 90.5% 43.8% KYNIGLN---LK-MFQVIGSPLAKARGQNVTIFYVNRLGYYPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPAE
`20 XP_002712114.1 82.6% 47.0% KYNLKLN---LK-MFQVIGSPLAKARGQNVTIFYVNRLGYYPWYTSE-GVPINGGLPQNISLQVHLEKADQDINYYIPAK
`21 XP_532444.4 86.1% 44.6% KYNIGLN---LK-MFQVIGSPLAKARGQNITIFYVNRLGYYPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPAE
`22 XP_002818436.2 82.6% 46.5% KYNLRLN---LK-IFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTSQ-GVPINGGLPQNISLQAHLEKADQDINYYIPAE
`23 NP_084124.1 81.2% 45.1% KYNLTLN---LK-VFQMVGSPRLKDRGQNVVIFYANRLGYYPWYTSE-GVPINGGLPQNTSLQVHLKKAAQDINYYIPSE
`24 XP_003134772.2 86.1% 43.9% KYNVRLN---LK-MFQVIGSPLARARGQNVTIFYVNRLGYYPWYTAQ-GVPINGGLPQNISLQVHLEKADQDINYYIPSE
`25 NP_036401.2 82.6% 46.5% KYNLRLN---LK-MFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPAE
`26 XP_003261316.2 90.5% 43.8% KYNLRLN---LK-MFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPSE
`27 XP_003407292.1 86.5% 44.4% KYNIRLN---LK-MFQVVGSPLAKARGQNVTIFYVNRLGYYPWYTSQ-GVPINGGLPQNISLQVHLEKADQDINYYIPAE
`28 XP_003586042.1 86.1% 43.9% KYNIRLN---LK-MFQVIGSPLARARGQNVTIFYVNRLGYYPWYTPQ-GVPINGGLPQNISLQVHLEKADQDIRYYIPSE
`29 NP_001094250.1 87.1% 40.5% KYNLAVN---LK-VFQMVGSPRLKDRRQNVVIFYANKLGSYPWYTSE-GVPINGGLPQNTSLQVHLEKAYQDINYYIPSE
`30 XP_003221368.2 82.4% 45.7% RYNVTIN---LK-MFHVIGSPFAKARGQNVTIFYVNRLGYYPWYTSQ-DVPVNGGLPQNFSLQTHLEKASEDINYYIPDE
`31 XP_003475093.1 88.3% 41.2% KYKLRLN---LE-MFQVAGSTLTKARGQNVTIFYPRRLGYYPWYTSQ-GVPINGGLPQNTSLKVHLKKVDQDIKYYIPVK
`32 NP_001090796.1 79.6% 45.4% RYKVDLD---LS-IFDIVANPNETLIGSNVTIFYHTHLGHYPYFTDE-GEPVNGGVPQNESLKKHLNKSEHDINRLIPNL
`33 XP_003221369.1 80.0% 44.6% RYDVDLD---LN-VFNVLSNPNETLSGPTVTIFYHTRLGYYPYFNDN-GDSINGGIPQNQSIIKHLNKAKSDIDHFITMK
`34 XP_003449274.1 83.2% 40.1% RYNITTN---VNHLFHIQGSPRADWTGQNVTIFYANRLGYYPHYTPH-GKAVFGGLPQNCSLDRHLFKAYQDINHFIPAE
`35 NP_001074140.1 79.8% 44.6% RFKVDLD---LS-VFDIVANHNETLSGPNVTIFYHSHLGYYPYYTSS-ETPINGGLPQNQSLSKHLSKARADIDKLIPIK
`36 XP_003217669.1 81.6% 43.6% RFKVQLD---FS-IFDLQASPNEGFVDQNLTIFYKERLGLYPYYNAQ-KVAVNGGVPQNSSLEEHLARLAVSISRYIRSE
`37 XP_001507903.3 83.8% 41.8% QYNTGIN---LR-TFHITGSPLAKARGQNVTIFFVNRLGYYPWYNAQ-EDPINGGLPQNASLQTHLIKANQDIRHYISAE
`38 XP_003449275.2 80.0% 44.0% RFKVDLD---LS-IFDIVANLNETLSGPNVTIFYHSHLGYYPYYSNS-GIPINGGLPQNQSISKHLGKARSDIDKLIPHK
`39 XP_001378617.3 80.2% 44.1% RFRVSLN---FS-VFDVKASPNEGFVNQNLTIFYRDRLGYYPYHDSH-LRPVHGGVPQNSSLMEHLERLPEGVRHYIRSP
`40 XP_003210019.2 82.0% 44.5% RFQVALD---FS-IFDLHASPNEGFVDQNLTIFYKERLGLYPYYNKR-WEPVNGGVPQQSSLAEHLARLQEGIGKYIRSA
`41 XP_414258.3 84.6% 42.5% RFQVALD---FS-VFDLQASPNEGFVDQNLTIFYKERLGLYPYYNKQ-GKPVNGGVPQKSSLAEHLARLQENIGKYIRSA
`42 NP_001080777.1 79.8% 44.9% RFNVHLD---LK-LFDLNASPNEGFVDQNLTIFYKERLGMYPYYDEH-GAPVSGGLPQNASLRAHLDKLPDGIQKYIRSR
`43 NP_001119986.1 83.0% 42.0% RFNVHLD---LK-LFDLNASPNEGFVDQNLTIFYKERLGMYPYYDEH-LAPVAGGLPQNASLRAHLDKLPEGIQKYIRSR
`44 XP_003221370.3 82.8% 41.7% RYSVDLD---LK-IFNILSNPNESLNGPIVTIFYANRLGFYPHFNDS-GDSVNGGIPQKESIIMHLIKASLDIDHSITMK
`45 XP_003448364.1 81.4% 40.9% RHKIRFQ---LD-QFQIVATPNEGFVNQNLTIFYKERLGLYPYFEQD-ETPVNGGLPQVASRTRHLEKMPEDVKKYIRSE
`46 XP_002189602.4 78.8% 43.7% KYNVSLS---LE-VFDVLANDQQSFTGQDITLFYSDKIGLFPYYTSG-GVPVNGGLPQNASLEAHIQQATQDIKVTLHSP
`47 NP_001074154.2 79.4% 42.8% -LKVPLD---LS-LFQAVTTPAR-VHNQSLSLFYKTRLGLFPYVDLHSMKEYNGGIPQRGNLSASLEKAKEEFLQFIPD-
`48 XP_003448436.2 83.6% 39.9% QYGVDLD---LG-MFNIVQNQNQTFMGQNITIFYAEKLGLYPRYSHQ-GEAINGGVPQNSSLDKHLKVARENVNTYIPDR
`49 XP_002813763.3 82.4% 37.9% RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSA-GRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQ
`50 XP_002935681.1 81.2% 42.2% RFGVTLD---LS-AFDIVLNQNHTFQGSEVVIFYSSQLGFYPYYDES-LSPVNGGLPQNNSLRDHLDKAFMDLLETISHP
`51 XP_001168599.1 82.4% 37.9% RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSA-GRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQ
`52 XP_687640.2 86.7% 37.4% RHDVTFQ---LD-QFQIVASPNEGFTKQNLTIFYQDRLGLYPYFKPD-STPVYGGLPQAASLTQHLEKMPDGLKKYIKDQ
`
`Petitioner Merck, Ex. 1058, p. 2
`
`
`
`53 NP_003764.3 82.4% 37.7% RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSA-GRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQ
`54 XP_003476739.1 83.2% 37.1% RHKVSLD---LK-AFDVQASPNEGFVNQSITIFYYDRLGLYPHFNEA-GMSVHGGVPQNGSLQEHLGMLRKPVEHYIRTR
`55 XP_003257153.1 82.4% 37.7% RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSA-GRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQ
`56 XP_002758427.1 81.6% 38.1% RLKVPLD---LN-AFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSA-GRSVHGGVPQNGSLWAHLEMLRDHVEHYIRTP
`57 XP_001102414.2 80.8% 40.2% RHSVDVD---VS-IFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPT-GEPVFGGLPQNASLIAHLARTFQDILAAIPAP
`58 NP_742037.2 80.2% 40.6% RHKVPLD---LR-AFDVEATPNEGFFNQNITTFYYDRLGLYPRFDAA-GMSVHGGVPQNGSLCAHLPMLKEAVERYIQTQ
`59 NP_999605.1 81.6% 38.5% RHKVPLDPKDMK-AFDVQASPNEGFVNQNITIFYRDRLGMYPHFDSV-GRSVHGGVPQNGSLWVHLKMLKGHVEHYIRTQ
`60 NP_001009754.1 81.6% 38.5% RHKMPLDPKDMK-AFDVQASPNEGFVNQNITIFYRDRLGMYPHFNSV-GRSVHGGVPQNGSLWVHLEMLKGHVEHYIRTQ
`61 NP_083196.2 82.4% 39.5% NFNVNMN---LQ-VFNIIPNPFETQSGSTITVFYPKELGYYPYFSED-GTSFYGGIPQKVNLSEHLRKSAGDIADAVTLW
`62 NP_001019491.1 79.8% 41.3% NFDVNMN---LQ-AFNIIPNPFETQSGSTIAVFYPKELGYYPYFSED-GISFYGGIPQNVNLSEHLRKSANDIANAVSLW
`63 NP_776772.1 81.6% 38.3% RHKMPLDPKDMK-AFDVQASPNEGFVNQNITIFYRDRLGMYPHFNSV-GRSVHGGVPQNGSLWVHLEMLKGHVEHYIRTQ
`64 NP_149349.2 82.0% 39.0% RHGVDVD---VS-VFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPT-GEPVFGGLPQNASLIAHLARTFQDILAAIPAP
`65 NP_001035086.1 79.4% 40.6% RFGVELD---LS-VFDIVHNPNQTFMGDNITIFYSDKLGKYPHYGPN-DEPIYGGVPQNASLNEHLKKADEDLRKNIPDP
`66 XP_003502176.1 85.3% 37.9% RFGVNMN---LQ-VFGIIPNPLETQSGSTIAIFYPDELGYYPYFSED-RRSIYGGIPQKGNLSEHLKKSASDIADTVTWW
`67 XP_003257149.1 80.8% 39.5% RHGVDVD---VS-VFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPT-GEPVFGGLPQNASLIAHLARTFQDILAAIPAP
`68 XP_002813766.6 80.8% 40.0% RHGVDVD---VS-VFDVVVNPGQTFRGPDMTIFYSSQLGTYPYYTPS-GEPVFGGLPQNASLIAHLARTFQDILAAIPAP
`69 NP_001017941.1 82.0% 38.5% KHGVDVD---IS-IFDVVTNPGQTFRGPNMTIFYSSQLGTYPYYTSA-GEPVFGGLPQNASLNAHLARTFQDILAAMPEP
`70 XP_002920567.1 79.0% 40.7% KYGVDVD---VS-VFDVVANPGQTFRGPDMTIFYSYQLGTYPYYTSA-GEPVFGGLPQNASLDTHLAHSFQDILAAIPAS
`71 XP_003476738.1 79.0% 40.9% NYSVDVD---VS-VFDVVANPGQTFFGPNMTIFYSSKLGTYPYYTTT-GEPVFGGLPQNASLGEHLAYAFHDIQATMPAP
`72 NP_999606.1 82.0% 38.8% RHGVDVD---VS-VFEVVVNPGQTFRGPNMTIFYSSQLGTYPYYTSA-GEPVFGGLPQNASLDVHLNRTFKDILAAMPES
`73 XP_002713406.3 78.6% 40.0% MHGVDVD---VS-VFDVVVNPRQAFRGPNVTIFYSSQLGTYPYYTPA-GEPVFGGLPQNASLATHLARTFHDILAAMPAP
`74 XP_003500449.1 79.2% 40.4% NYGVDVD---VS-VFDVIANKEQSFQGPNVTIFYSWQLGTYPYYTST-GEPIFGGLPQNASLVTHLACTFQDIKAVMPEP
`75 XP_001509131.1 79.0% 38.2% KFHVDVD---LD-VFDVVANPGEAFMGREMTIFYSNKLGLYPSYTSS-GQPLHGGLPQNASLATHLAQAQLDIQAAIPKS
`76 XP_001139800.4 79.8% 38.6% FFNMAIN---LQ-VFNIISNPLETQSGSKIAIFYPNELGYYPYLSQD-GKSFNGGIPQNVSLSEHLRKTADDIGEGVPWW
`77 NP_032343.3 78.8% 39.6% EYGVDVD---VS-VFDVVANKEQSFQGSNMTIFYREELGTYPYYTPT-GEPVFGGLPQNASLVTHLAHTFQDIKAAMPEP
`78 NP_997499.2 80.4% 38.3% DHGVDVD---VS-VFDVVANKEQNFQGPNMTIFYREELGTYPYYTPT-GEPVFGGLPQNASLVTHLAHAFQDIKAAMPEP
`79 XP_001168796.1 77.8% 35.4% RHGVDVD---VS-VFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPT-GEPVFGGLPQNASLIAHLARTFQDILAAIPAP
`80 NP_997482.2 76.8% 36.7% RFGVHLP---LD-ALGIIANHGQRFHGQNITIFYKNQFGLYPYFGPR-GTAHNGGIPQAVSLDHHLAQAAHQILHNLG-S
`81 NP_001193181.1 77.8% 37.4% RFGVPLP---LE-ALGISANRGQHFHGQNVTIFYKNRLGFYPYLGPR-GTVHNGGIPQAVPLGCHLARAAHQIRHSLW-P
`82 NP_001186958.1 79.4% 35.4% RFGVHLP---LN-ALGIIANRGQHFHGQNMTIFYKNQLGLYPYFGPR-GTAHNGGIPQALPLDRHLALAAYQIHHSLR-P
`83 NP_999604.1 71.9% 39.4% RFGVHLP---LE-ALGITANHGQRFHGQNITIFYKSQLGLYPYFGPR-GTAHNGGIPQAVSLDHHLARAAYQIHRSLR-P
`84 XP_001493753.3 71.9% 39.4% RFGVHLP---LE-ALGITANCGQRFHGQKITIFYKNQLGLYPYLGPR-GTAHNGGIPQAVPLDCHLARAAYQIHHSLR-P
`85 NP_001121765.1 76.4% 38.0% RYGVSLP---LQ-QYNIIHNSHQRFQGQNMSIFYQRRLGLYPYISRE-GVKVNGGLPQEGYLKAHLSLAGVEIREKLR-S
`86 NP_821139.2 72.1% 38.6% HFGVHLP---LD-ALGIVANHGQHFHGQNISIFYKNQFGLYPYFGPR-GTAHNGGIPQAVSLDHHLARAAHQILHSLG-S
`87 XP_002128103.1 72.9% 35.4% KYNVPID---LS-SFDIIHNPNEEYVGNQMVIFYAALLGLYPKYGTD-GLAVNGGIPQNGNISAHYEKCVDDIMARIPDS
`88 XP_003642042.3 69.7% 37.2% RFGVGLP---LA-DYGIVENRGGRFAGQNITIFYKNKFGLYPYISPQ-GVPHNGGIPQRAPLRAHLARVAGDVRLRLR-P
` consensus/100% ..........ht..h.h..s......t..hshaa...hG.aP.ht........sGlPQ...h..ph......h...h...
` consensus/90% pht..hs...hp.hFtl.ss..tth.s.sholFY.ppLGhYPhhs...t.sh.GGlPQ..sL..HLthh.tpl.hhh...
` consensus/80% +atl.ls...lp.hFplhuss.tthhspslTIFY.scLGhYPahs.t.u.sh.GGlPQthsL..HLtph.pcl.hhh...
` consensus/70% +aslsls...lp.hFslhusPtpshhGpslTIFYhs+LGhYPaassp.GhslpGGlPQssSLptHLt+stpDIthhl.t.
`
` cov pid 161 . . . 2 . . . . 240
` 1 NP_003108.2 100.0% 100.0% DNLGMAVIDWEEWRPTWARN-WKP-KDVYKNRSIELVQQQNVQLSLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHL
` 2 XP_003318802.2 100.0% 96.3% DNLGMAVIDWEEWRPTWARN-WKP-KDVYKNRSIELVQQQNVQLSLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHL
` 3 XP_003261317.2 100.0% 93.3% DNLGMAVIDWEEWRPTWARN-WKP-KDVYKNRSIELVQQQNVQLSLAEATEKAKQEFEKAGKDFMVETIKLGKLLRPNHL
` 4 XP_001086882.2 100.0% 86.9% DNLGMAVIDWEEWRPTWARN-WKP-KDVYKNRSIELVQQQNVQLSLPQATDKAKQEFEKAGKDFMLETIKLGRSLRPNHL
` 5 NP_001076141.2 99.4% 67.1% DNVGLAVIDWEEWRPTWLRN-WKP-KDIYRIKSIELVQQQNPQINLTEATKLAKIEFEKAGKCFMEETLKLGRLFRPNHF
` 6 XP_002919069.1 94.7% 66.8% DSIGLAVIDWENWRPIWVRN-WKP-KDIYKHQSIELVQQHHIELNVTEATKIAKADFEKAGKCFMQETLKLGKSLRPNYL
` 7 NP_999176.1 94.5% 65.7% DKVGLSVIDWENWRPTWERN-WKE-KAIYRRQSIELVQQKNIKLTPAAATKLAKREFEKAGKTFMQETLKLGKLLRPNHL
` 8 XP_002686960.3 94.1% 65.8% DNVGLAVIDWENWRPTWVRN-WKP-KDVYKKASIELVLQQNRHFTLKEATKRAKADFEKAAKSFMQETLKLGKFLRPNHL
` 9 NP_001008413.3 99.6% 61.1% DSVGLAVIDWENWRPTWARN-WKP-KDVYRDESVELVLQKNPQLSFPEASKIAKVDFETAGKSFMQETLKLGKLLRPNHL
`10 XP_003502178.1 94.5% 62.1% DNVGLAVIDWEDWRPTWSRN-WKP-KDIYKHKSIELVKQQNKQLNITEATRRAKKDFEQAARSFMEGTLKLGKSLRPNHL
`11 NP_001166492.1 96.4% 59.2% DSVGLAVIDWEEWRPTWTRN-WRP-KDIYRNKSIELVKSQHPQYNHSYAVAVAKRDFERTGKAFMLETLKLGKSLRPSSL
`12 NP_001019492.1 94.5% 61.1% DNVGLAVIDWEDWRPTWSRN-WKF-KDIYRNKSIEFVQQQNTQLNLTEAVKRAKQEFEEAARNFMEQTLKLGKLLRPNHL
`13 XP_001507937.2 95.8% 57.3% EKSGLAVIDWENWRPLWIRN-WKP-KDIYRNRSIELVQQKDVTLNFSEAWNIAKVDFEKAARNFMQQSLKLGKTLRPNRL
`14 NP_001073344.1 94.9% 57.8% DKLGLAIIDWEEWRPTWLRN-WKP-KDNYRNKSIELVQSTNPGLSITEATQKAIQQFEEAGRKFMEGTLHLGKFLRPNQL
`15 XP_003502177.1 94.9% 55.0% DKFGLAVIDWEEWRPTWMRN-WKP-KDVYRNKSIALVQANNAGISIEDATQKAKDEFETAGRHFMEETLKLGKSVRPRHL
`16 XP_002190553.4 90.1% 54.0% EQLGLAVIDWENWRPVWIRN-WGS-KDIYRQESIELVQQRDLSISEAESRTIAKMEFEFAAKSFMLETLKLGIETKPNRL
`17 XP_002932242.3 91.9% 45.6% KQNGLAVIDWEDWRPIWIRN-WAS-KAVYKMNSIEFARQMDITMTHKKAALIAEAQFESAAQNFMLQTLRLGKAMRPNYL
`18 NP_001082194.1 90.9% 45.4% KQHGLAVIDWEEWRPLYTRN-WAS-KAVYKKQSIEFAQQMDITMTHKKAVGIAAAQFESAAKNLMLETLKLGKTMRPNYL
`19 XP_002919077.1 90.5% 43.8% DFSGLAVIDWEYWRPQWARN-WNT-KDVYRQKSRKLISDMQENISATDIEDLAKETFEESAKAFMKETIELGMKSRPKGL
`20 XP_002712114.1 82.6% 47.0% DFSGLAVIDWEYWRPQWARN-WNT-KDVYRQKSRKLISDMQANVSATDIEYLAKATFEESAKAFMKETLKLGIKSRPKGL
`21 XP_532444.4 86.1% 44.6% DFNGLAVIDWEYWRPQWARN-WNT-KDVYRQKSRKLISDMQENVSATDIEYLAKATFEESAKAFMKETIELGIKSRPKGL
`22 XP_002818436.2 82.6% 46.5% DFSGLAVIDWEYWRPQWARN-WNA-KDVYRQKSRKLISDMGKNVSATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGL
`23 NP_084124.1 81.2% 45.1% NFSGLAVIDWEYWRPQWARN-WNT-KDIYRQKSRTLISDMKENISAADIEYSAKATFEKSAKAFMEETIKLGSKSRPKGL
`24 XP_003134772.2 86.1% 43.9% DFSGLAVIDWEYWRPQWARN-WNT-KDVYRQKSRKLISELQENVSMADIEYLAKTTFEESAKAFMKETIELGIKSRPKGL
`25 NP_036401.2 82.6% 46.5% DFSGLAVIDWEYWRPQWARN-WNS-KDVYRQKSRKLISDMGKNVSATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGL
`26 XP_003261316.2 90.5% 43.8% DFSGLAVIDWEYWRPQWARN-WNA-KDVYRQKSRKLISDMGRNVSATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGL
`27 XP_003407292.1 86.5% 44.4% DFSGLAVIDWEYWRPQWARN-WNA-KNVYRQKSRKLISETQENVSATDIEYLAKATFEESAKAFMKETIKLGIKSRPKGL
`28 XP_003586042.1 86.1% 43.9% DFSGLAVIDWEYWRPQWARN-WNT-KDIYRQKSRKLISETQENASAADIEYLAKATFEESAKAFMKETIELGIKSRPKGL
`29 NP_001094250.1 87.1% 40.5% NFSGLAVIDWEYWRPQWARN-WNT-KDIYRQKSRTLISDMKENISTADIEYLAKATFEKSAKAFMEETIKLGIKSRPKGF
`30 XP_003221368.2 82.4% 45.7% DFTGLAVIDWEHWRPQWERN-WNT-KNIYRRQSRKLISAMQQNVSTNALEHLAKFSFEQCAKAFMKETIELGIKSRPKGL
`31 XP_003475093.1 88.3% 41.2% DFRGLAVIDWEYWRPQWDRN-WNA-KDVYRRKSKELIFDLQQNVKASDIEYLAKATFEESAKAFMIETIKLGIKRRPKGL
`32 NP_001090796.1 79.6% 45.4% DFKGLGVVDWENWRPQWDRN-WGS-KLIYRNKSIELVKNHHPTWSDEQLKKKAKEEFDNAAKEFMTKTIALAQEKRSKGL
`33 XP_003221369.1 80.0% 44.6% KFQGLGVIDWENWRPQWDRN-WGN-KTIYKNKSLELVRKRHPHWPKNAVHKAAKEEFENAGKNFMNSTLSLAENMRPSGL
`34 XP_003449274.1 83.2% 40.1% DFRGLAVIDWEFWRPQWSRN-WHK-KDIYRRKSKELTKKAYINVTAAQVEELARRRFEKSAKIFMLKTIQLGRQLRPSAL
`35 NP_001074140.1 79.8% 44.6% DFHGLGVIDWENWRPQWVRN-WGS-KDIYRNKSKELIRKLHPGWPQSKVENEAKEVFERAGQVFMNSTLLLAESRRPHGL
`
`Petitioner Merck, Ex. 1058, p. 3
`
`
`
`36 XP_003217669.1 81.6% 43.6% IKEGLAVIDWEEWRPIWIRN-WQP-KDIYRIASRQLVLSRHVELSEDQVKKKAQYEFESSASSFMKETLRVAKSFRPQQL
`37 XP_001507903.3 83.8% 41.8% DFRGLAMIEWEYWRPQWSCN-WNA-KDVYRRNSRQLISERLRNLSDNSLEHSAKVSFEESAKAFMKETIELGMRNRPRAL
`38 XP_003449275.2 80.0% 44.0% DFRGLGVIDWENWRPQWVRN-WGS-KDIYRKRSREQIRKLHPNWPESKVEKEAKEGFERAGQAFMNLTLALAQGRRPGGL
`39 XP_001378617.3 80.2% 44.1% DREGLAVIDWEDWRPVWIRN-WQS-KDVYRKVSRQLVSLRHPTWSQEQVGKQAQYEFEFAARQFMLETLRWAKETRPRQL
`40 XP_003210019.2 82.0% 44.5% TSEGLAVIDWEEWRPIWMRN-WKP-KDVYQEVSRELVKQKQPFWSPEEVNKQAVFEFESAARQFMVRTLRYAKSFRPKQL
`41 XP_414258.3 84.6% 42.5% TSEGLAVIDWEEWRPIWMRN-WKP-KDVYQEVSRELVEQRQPFWSPEKVNKQAVFEFESAARHFMVTTLRYAKSFRPKQL
`42 NP_001080777.1 79.8% 44.9% DKDGLAVIDWEEWRPIWVRN-WQN-KNVYRNNSRNLVASRHPSWPREQVEKEALYDFENAAREFMMETLRHAKNYRPRQL
`43 NP_001119986.1 83.0% 42.0% DKDGLAVIDWEEWRPIWVRN-WQN-KDVYRQNSRNLVSSRHPTWPREKVDKEALYEFENAAREFMTETLRHAKNYRPRQL
`44 XP_003221370.3 82.8% 41.7% TFQGLGVIDWENWRPQWDRA-WGR-KNIYRDASLELVRKRHPHWPEDAIKKTARKEFENAGRNFMTTTLSLVKKLRPNGL
`45 XP_003448364.1 81.4% 40.9% WATGLAVIDWEDWRPLWIRN-WEP-KHIYRRHSEELVRQKNPTWTSDRVKRVAQQEFEMSARLFMLDTLKQAKNLRPNQL
`46 XP_002189602.4 78.8% 43.7% DYSGLAVIDWEKWRPLWIRN-WDS-MEIYRQKSEELVQQQHPQWPPKEVEEMAKQQFEKSACDFMNKTLWLGKSLRPSAY
`47 NP_001074154.2 79.4% 42.8% SSSGLAVMDWEEWLPIFDRN-FDL-KKIYMELSINYTLEQNSSLSPQQAATEAKQQFQKEARRFMEETLKKGINLRPRYL
`48 XP_003448436.2 83.6% 39.9% GFPGLGVVDWESWRPEWERN-WDT-KKIYQEGSKALVRSKHPDWSPKQVDDAARVEFNKAARNFMEETLKLGQAARPDGL
`49 XP_002813763.3 82.4% 37.9% ESVGLAVIDWEDWRPVWVRN-WQD-KDVYRRSSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHL
`50 XP_002935681.1 81.2% 42.2% GFNGVAVVDWESWRPLWARN-WDK-MRVYQQSSQDLVKEFYPHLPPDKVIELAKAEFETAARKLMQSTLELGRALRPKGL
`51 XP_001168599.1 82.4% 37.9% ESAGLAVIDWEDWRPVWVRN-WQD-KDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHL
`52 XP_687640.2 86.7% 37.4% AVKGLAVIDWEEWRPLWIRN-WGP-KLIYRDRSQRLVAEKNPTWPLDQVTKVAQQEFELSARKFMLETLRLAKSLRPQQL
`53 NP_003764.3 82.4% 37.7% ESAGLAVIDWEDWRPVWVRN-WQD-KDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHL
`54 XP_003476739.1 83.2% 37.1% EPAGLAIIDWEHWRPVWVRN-WQD-KDVYRQWSRQLVASRHPDWPKDQIVKEAQYEFEFAARQFMLKTLHYVKSVRPQHL
`55 XP_003257153.1 82.4% 37.7% ESAGLAVIDWEDWRPVWVRN-WQE-KDVYRRSSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHL
`56 XP_002758427.1 81.6% 38.1% EPAGLAVIDWEDWRPVWVRN-WQD-KDVYRRSSRQLVASRHPDWQADRVVKQAQYEFECAARQFMLETLRYVKAVRPRHL
`57 XP_001102414.2 80.8% 40.2% DFSGLAVIDWEAWRPRWAFN-WDT-KDIYRQRSRALVQAQHPDWPVTQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`58 NP_742037.2 80.2% 40.6% EPAGLAVIDWEEWRPVWVRN-WQE-KDVYRQSSRQLVASRHPDWPSDRIVKQAQYEFEFAARQFMLNTLRYVKAVRPQHL
`59 NP_999605.1 81.6% 38.5% EPAGLAVIDWEDWRPVWVRN-WQD-KDVYRRLSRQLVASRHPDWPPDRVVKQAQYEFEFAARQFMLETLRFVKAFRPQHL
`60 NP_001009754.1 81.6% 38.5% EPAGLAVIDWEDWRPVWVRN-WQD-KDVYRRLSRQLVASHHPDWPPERIVKEAQYEFEFAARQFMLETLRFVKAFRPRHL
`61 NP_083196.2 82.4% 39.5% RSEGLAVIDWEGWRPQWDRN-WGS-RMIYKNHSLAFTRHHHPDWAETKVRTAAQKEFENAGRSFMNVTLTLALEMRPKRL
`62 NP_001019491.1 79.8% 41.3% RSEGLAVIDWEGWRPQWDRN-WGG-RIIYKNHSLAFTRHHHPDWAETKVRTVAQQEFENAGKSLMNVTLTLALEMRPKRL
`63 NP_776772.1 81.6% 38.3% EPAGLAVIDWEDWRPVWVRN-WQD-KDVYRRLSRHLVAIRHPDWPPERVAKEAQYEFEFAARQFMLETLRFVKAFRPRHL
`64 NP_149349.2 82.0% 39.0% DFSGLAVIDWEAWRPRWAFN-WDT-KDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`65 NP_001035086.1 79.4% 40.6% EFQGLAIIDWEKWRPLWERN-WDS-KEVYWKASRAIVKAKHPTWSPDQIETEAVKEFEASSMAFMVETLKLGRRERSGGL
`66 XP_003502176.1 85.3% 37.9% RSEGLAVIDWEGWKPQWDRN-WGS-RIIYKNHSLAFTRHHHPDWSEAKVRTVAQQEFENAGRSFMNITLTLALEMRPKRL
`67 XP_003257149.1 80.8% 39.5% EFSGLAVIDWEAWRPRWAFN-WDT-KDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`68 XP_002813766.6 80.8% 40.0% DFSGLAVIDWEAWRPRWAFN-WDT-KDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`69 NP_001017941.1 82.0% 38.5% RFSGLAVIDWEAWRPRWAFN-WDT-KDIYRQRSRALVQKQHPDWLAPRVEAAAQDQFEGAAEEWMAGTLKLGQALRPQGL
`70 XP_002920567.1 79.0% 40.7% DFSGLAVIDWEAWRPRWAFN-WDT-KDIYRQRSRTLVQGQHPDWPAPWVEAAARDQFQEAARAWMAGTLKLGQALRPRGL
`71 XP_003476738.1 79.0% 40.9% DFSGLVVIDWEAWRPRWAFN-WDT-KDIYRQRSQALIQAQHPDWPESQVKTVAKDQFQKAAQAWMAGTLQLGQALRPRGL
`72 NP_999606.1 82.0% 38.8% NFSGLAVIDWEAWRPRWAFN-WDA-KDIYRQRSRALVQKQHPDWPAPWVEAAAQDQFQEAAQTWMAGTLKLGQTLRPHGL
`73 XP_002713406.3 78.6% 40.0% DFSGLVVIDWEAWRPRWAFN-WDA-KDIYRQRSRALVRATHPDWPAPRVDQAAQDQFQGAAQAWMTDTLQLGRLLRPGGL
`74 XP_003500449.1 79.2% 40.4% DFSGLAVIDWEAWRPRWAFN-WDS-KDIYRQRSVALVQAEHPDWPETLVEAVAQDQFQEAAQAWMAGTLQLGQILRPHGL
`75 XP_001509131.1 79.0% 38.2% NYWGLAVIDWESWRPLWALN-WDS-KDVYRERSRALVREEHPDWSSWQVEEEAVIQFQTAARAWMSQTLQLGQTLRPRGL
`76 XP_001139800.4 79.8% 38.6% RSEELVVIDWESWKPQWDRN-RGS-RIIYKNHSLAFTRNHHPYWSEMKVETVAQEEFENAGKNFMNITLTLALEMRPKCL
`77 NP_032343.3 78.8% 39.6% DFSGLAVIDWEAWRPRWAFN-WDS-KDIYRQRSMELVQAEHPDWPETLVEAAAKNQFQEAAEAWMAGTLQLGQVLRPRGL
`78 NP_997499.2 80.4% 38.3% DFSGLAVIDWEAWRPRWAFN-WDS-KDIYQQRSMELVRAEHPDWPETLVEAEAQDQFQEAAQAWMAGTLQLGQVLRPRGL
`79 XP_001168796.1 77.8% 35.4% DFSGLAVIDWEAWRPRWAFN-WDT-KDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGL
`80 NP_997482.2 76.8% 36.7% SFAGLAVLDWEEWYPLWAGN-WGTHRQVYQAASWAWAQQMFPDLNPQEQLHKAQTGFEQAARALMEHTLRLGQMLRPHGL
`81 NP_001193181.1 77.8% 37.4% GFAGLAVLDWEEWCPLWAGN-WGR-RQVYRAASWAWAQWVFPNLDPQEQLHKARVGFEQAARALMEDTLWLGRALQPQGL
`82 NP_001186958.1 79.4% 35.4% GFAGPAVLDWEEWCPLWAGN-WGR-RRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARALMEDTLRVAQALRPHGL
`8
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