STEPHEN F. MARTIN
`Address: Department of Chemistry, The University of Texas, Austin, TX 78712
`Phone: (512) 971-7353 (cell); E-mail: sfmartin@utexas.edu; Group Homepage: https://sites.cns.utexas.edu/smartin
`Education
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`University of New Mexico (BS, 1968)
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`Princeton University (PhD, 1972)
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`University of Munich (Alexander von Humboldt Postdoctoral Fellow, 1972-73)
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`Massachusetts Institute of Technology (NIH Postdoctoral Fellow, 1973-74)
`Employment
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`University of Texas – Assist. Professor (1974-80); Assoc. Professor (1980-86); Professor (1986-2024)
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`NuvoNuro, Inc. – President and co-founder (2023-present)
`Selected Honors and Awards
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`National Institutes of Health Research Career Development Award 1980-85
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`American Cyanamide Academic Awardee, 1986
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`Alexander von Humboldt Prize, 1995
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`Arthur C. Cope Scholar Award, 1996
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`Novartis Chemistry Award, 1997
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`Ta-Shue Chou Foundation Award (Academica Sinica), 2000
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`M. June and J. Virgil Waggoner Regents Chair of Chemistry, 2000-2024
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`Japan Society for the Promotion of Science Award, 2001
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`Wyeth Research Award, 2003
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`Fellow of Institute of Cellular and Molecular Biology, University of Texas, 2003-2004
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`Fellow of American Association for the Advancement of Science 2005-
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`International Society of Heterocyclic Chemistry (ISHC) Senior Award, 2013
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`Herbert C. Brown Lecturer Award, 2014
`Ernest Guenther Award in the Chemistry of Natural Products (ACS), 2017
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`Designated as Fellow of the American Chemical Society, 2018
`Gund-Harrington Scholar Award, 2019-2023
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`Selected Other Professional Recognition and Activities
`NIH Medicinal Chemistry Study Section, 1983-87
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`Symposium Executive Officer for 31st National Organic Symposium, 1989
`Executive Committee, Division of Organic Chemistry ACS, 1988-1990
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`Member of Editorial Advisory Board of "Progress in Heterocyclic Chemistry", 1988-1996
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`Visiting Professor, University of Paris VI, Fall 1990
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`Visiting Professor, National Taiwan University, Spring 1991
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`Member of Board of Editors, Organic Synthesis, 1991-1999
`Member of Advisory Board, Organic Synthesis, 1999-
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`Consultant, Procter and Gamble, 1992-1998
`Consultant, Elan Pharmaceutical (formerly Athena Neurosciences), 1992-2005
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`Regional Editor for the Americas of Tetrahedron, 1992-2019
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`Executive Board of Editors of Tetrahedron Publications, 1992-2019
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`Fellow Royal Society of Chemistry, 1996–present
`Executive Committee, Division of Organic Chemistry ACS, 1998-2000
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`Visiting Professor, University of Versailles, 1999
`Consultant for Abbott Laboratories, 2000-2005
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`Visiting Professor, University of Bordeaux, 2004
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`Consultant ICOS Corporation, 2003-2007
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`Chair, Department of Chemistry and Biochemistry, 2004-2008
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`Organizer of 9th Tetrahedron Symposium, Berkeley, CA, 2008
`Adjunct Professor, UTMB School of Medicine 2005-2009
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`Co-Founder of Texas Institute for Drug and Diagnostic Development, 2005-2014
`Member, Science Foundation Ireland Chemistry Review Panel, Research Frontiers Program, 2007-2009
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`Member, Keystone Symposium Advisory Board 2007-2008
`Member, Thieme-IUPAC Prize in Synthetic Organic Chemistry Selection Committee, 2008
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`Member, Advisory Board of International Society of Heterocyclic Chemistry, 1992-1994 and 2011-2014
`Member, EVISE User Advisory Board, 2010-2015
`Member, Promotion and Tenure Committee, Jackson School of Geological Sciences, 2011-2014
`Chairman, Executive Board of Tetrahedron Publications, 2013–2018
`Chair, Canvassing Committee, Herbert C. Brown Award for Research in Synthetic Methods, 2013-2015
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`Memberships
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`Honorary and Professional Societies - Phi Beta Kappa, Phi Kappa Phi, Kappa Mu Epsilon, Sigma Xi,
`American Chemical Society, Royal Society of Chemistry (London)
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`Books
` 1. R. M. Roberts, J. C. Gilbert, and S. F. Martin. Experimental Organic Chemistry: A Miniscale
`Approach, Philadelphia: Saunders College Publishing, 1994, xxvi + 777 pp.
` 2. R. M. Roberts, J. C. Gilbert, and S. F. Martin, Pre-Lab Exercises for Experimental Organic
`Chemistry: A Miniscale Approach Philadelphia: Saunders College Publishing, 1994, 130 pp.
` 3. R. M. Roberts, J. C. Gilbert, and S. F. Martin, Instructor's Manual for Experimental Organic
`Chemistry: A Miniscale Approach Philadelphia: Saunders College Publishing, 1994, iv + 330
`pp.
`J. C. Gilbert and S. F. Martin. Experimental Organic Chemistry: A Miniscale and Microscale
`Approach, 2nd. Ed., Philadelphia: Saunders College Publishing, 1998, xxiv + 723 pp.
`J. C. Gilbert and S. F. Martin, Pre-Lab Exercises for Experimental Organic Chemistry:
`Miniscale and Microscale Approaches Philadelphia: Saunders College Publishing, 1998, 130
`pp.
`J. C. Gilbert and S. F. Martin, Instructor's Manual for Experimental Organic Chemistry:
`Miniscale and Microscale Approaches, Philadelphia: Saunders College Publishing, 1998, iv +
`330 pp.
`S.F. Martin and J. C. Gilbert 1H NMR Spectra of Simple Molecules, a CD-ROM, Philadelphia:
`Saunders College Publishing, 1998.
`J. C. Gilbert and S. F. Martin, Experimental Organic Chemistry: A Miniscale & Microscale
`Approach, 3rd. Ed., Philadelphia: Harcourt College Publishers, 2002, xxiv+ 820 pp.
`J. C. Gilbert and S. F. Martin, Student Tools CD, Philadelphia: Harcourt College Publishers,
`2002.
`J. C. Gilbert and S. F. Martin, Instructor's Manual to Accompany Experimental Organic
`Chemistry: A Miniscale Approach Philadelphia: Saunders College Publishing, 2002, xii + 316
`pp.
`J. C. Gilbert and S. F. Martin, Experimental Organic Chemistry: A Miniscale & Microscale
`Approach, 4th Ed., Thomson, Brooks/ColePhiladelphia: 2006, xxi+ 927 Diastereoselective
`addition of monoorganocuprates to a chiral fumarate: reaction development and application to
`natural product synthesis pp.
`J. C. Gilbert and S. F. Martin, Experimental Organic Chemistry: A Miniscale & Microscale
`Approach, 5th Ed., Thomson, Brooks/ColePhiladelphia: 2010.
`J. C. Gilbert and S. F. Martin, Experimental Organic Chemistry: A Miniscale & Microscale
`Approach, 6th Ed., Thomson, Brooks/ColePhiladelphia: 2015.
`Patent Applications
`1.
`Martin, S, F.; Granger, B. A.; Hergenrother, P. J.; Knezevic, C. E.; Parkinson, E. I. "Novel
`Anticancer Agents from the Diverted Total Synthesis of Actinophyllic Acid. U.S. Provisional
`Patent Application 61/844,738; filed July 10, 2013.
`Martin, S. F.; Sahn, J. J.; Scott, L.; Pierce-Shimomura, J. T. “Compounds and methods for
`treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic
`pain.” U.S. Provisional Patent Application US 61/846,234;
`filed July 15, 2013;
`WO2015009742A2, 2015.
`Martin, S. F.; Sahn, J. J.; Meis, A. R. "Novel Inhibitors of Trypanosoma brucei Methionyl t-
`RNA Synthetase
`(Tb MetRS)
`for
`the Treatment of African Tyrpanosomiasis."
`UTSB.P1028US.P1; Application No. PCT/US2015/038974; filed 14 July 2015.
`Martin, S. F.; Sahn, J. J.; Hodges, T. R., “Piperazinyl Norbenzomorphan Compounds and
`Methods for Using the Same." US 62/243,568 (provisional patent filed October 19, 2015.
`(6752MAR)
`Martin, S. F.; Sahn, J. J. “Sigma Receptor Binders. 1.” US 62/329,578 (provisional patent filed
`4/29/2016).
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`Martin, S. F.; Sahn, J. J.; Wood, M. D. “Sigma Receptor Binders. 2.” US 62/329,864
`(provisional patent filed 4/29/2016); WO 2017/190107; PCT/US2017/030296.
`Martin, S. F.; Sahn, J. J.; Linkens, K. T. “Sigma Receptor Binders. 3.” US 62/329,869
`(provisional patent filed 4/29/2016). WO 2017/190109; PCT/US2017/030300
`Assaf, A.; Schmidt, H. R.; Wood, M. D.; Sahn, J. J.; Martin, S. F.; Kruse, A. C. "Methods of
`Treatment for Cancer, Sterol Homeostasis, and Neurological Diseases" (provisional patent filed
`2/23/2017) US 62/462,435
`Martin, S. F.; Sahn, J. J. "Selective Sigma-2 Receptor Ligands as Modulators of TMEM97".
`(PCT application filed 5/17/23; US2023067129)
`Publications [h-index = 78 (Google Scholar); h-index = 64 (Web of Science)]
`358. V. M. Hong, A. D. Rade, S. M. Yan, A. Bhaskara, M. S. Yousuf, M. Chen, S. F. Martin, D. J.
`Liebl, T. J. Price, and B. J. Kolber, eNeuro 2024, 11, ENEURO.0488-23.2024. Loss of Sigma-2
`Receptor/TMEM97 Is Associated with Neuropathic Injury-Induced Depression-Like Behaviors
`in Female Mice.
`357. G. D. Walby, Q. Gu, H. Yang, and S. F. Martin, Bioorganic Chem. 2024, 145, 107191.
`Structure-Affinity Relationships of Novel s2R/TMEM97 Ligands.
`356. M. S. Yousuf, J. J. Sahn, H. Yang, E. T. David, S. Shiers, D. M. Royer, C. D. Garcia, J. Zhang,
`V. M. Hong, A. Ahmad, B. J. Kolber, D. J. Liebl, S. F. Martin, T. J. Price Proc. Natl Acad. Sci
`(USA) 2023, 120, e2306090120. Validation of s2R/TMEM97 as a neuropathic pain target:
`Specificity, human expression and mechanism of action.
`355. Y. Lu, Q. Gu, and S. F. Martin Eur. J. Med. Chem. 2023, 257, 115488. Structure-Affinity
`Relationships of Stereoisomers of Norbenzomorphan-Derived s2R/TMEM97 Modulators.
`354. H. Wang, Z. Peng, Y. Li, J. J. Sahn, T. R. Hodges, T.-H. Chou, Q. Liu, X. Zhou, S. Jiao, V.
`Porciatti, D. J. Liebl, S. F. Martin, R. Wen, Sci. Rep. (Nature) 2022, 12: 20753. σ2R/TMEM97 in
`retinal ganglion cell degeneration.
`J. Jin, N. Arbez, J. J. Sahn, Y. Lu, K. T. Linkens, T. R. Hodges, A. Tang, R. Wiseman, S. F.
`Martin, and C. A. Ross, ACS Chem. Neurosci. 2022, 13, 2852. Neuroprotective Effects of
`σ2R/TMEM97 Receptor Modulators in Neuronal Model of Huntington's Disease. (PMID:
`36108101; PMCID: PMC954794)
`352. M. D. Wood, J. J. Sahn, and S. F. Martin, Eur. J. Med. Chem. 2022, 243:114696. Targeting
`s2R/TMEM97 Receptors with Novel Aminotetralins.
`351. G. D. Walby and S. F. Martin, Eur. J. Med. Chem. 2022, 235, 114310. Preparation and
`Evaluation of Sigma Receptor Binding Affinities of Novel Analogs of 2-Aryl Piperidines.
`350. S. F. Martin, Acc. Chem. Res. 2022, 55, 2397. Invited article. Bridging Known and Unknown
`Unknowns: From Natural Products and Their Mimics to Unmet Needs in Neuroscience.
`349. Z. Wang and S. F. Martin, Chem. Eur. J. 2022, e202200311. Design, Synthesis and Evaluation
`of Novel Carbazole-Derived Photocages.
`348. Z. Wang and S. F. Martin, Tetrahedron 2021, 103, 132551. Concise Stereoselective and
`Stereodivergent Syntheses of (±)-Melicolones A and B. invited article
`347. M. D. Wood, D. W. Klosowski, and S. F. Martin Tetrahedron 2021, 89, 132150. Tandem
`Vinylogous Mannich and Hetero Diels-Alder Reactions: Concise Total Synthesis of (±)-
`Alstoscholarisine E. invited article.
`346. S. G. Quadir, S. M. Tanino, C. D. Rohl, J. J. Sahn, E. J. Yao, L. dos Reis Cruz, P. Cottone, S. F.
`Martin, V. Sabino, Neuropharmacol. 2021, 184, 108409. The Sigma-2 Receptor
`/
`Transmembrane protein 97 (s2R/TMEM97) Modulator JVW-1034 Reduces Heavy Alcohol
`Drinking and Associated Pain States in Male Mice.
`345. G. A. Abeykoon, J. J. Sahn, and S. F. Martin Tetrahedron Lett. 2021, 66, 152828. Novel
`Substituted Triazolo Benzodiazepine Scaffolds to Explore Chemical Space.
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`335.
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`2019, 10, 1595. Neuroprotective Efficacy of a Novel Sigma 2 Receptor/TMEM97 Modulator
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`344. L. T. Lepovitz and S. F. Martin, J. Org. Chem. 2021, 86, 10946. Biomimetically Inspired, One-
`Step Synthesis of Exotine A and Exotine B; selected for special issue on natural product
`synthesis
`343. S. Blumberg and S. F. Martin, ARKIVOC, 2021, part v, 7. Racemic or enantioselective osmium-
`catalyzed dihydroxylation of olefins under near-neutral conditions.
`342. Z. Wang and S. F. Martin, Org. Lett. 2020, 22, 9071. Concise Syntheses of (±)-Melicolone A
`and (±)-Melicolone B. Highlighted in SYNFACTS: Synfacts 2021, 17, 0219. Also featured in
`Org. Chem. Highlights: Methods for Carbocyclic Construction.
`341. D. L. Cramer, J. Tian, B. Cheng, J. H. Clements, R. M. Wypych, and S. F. Martin, Eur. J. Med.
`Chem. 2020, 208:112771. Some Thermodynamic Effects of Varying Nonpolar Surfaces in
`Protein-Ligand Interactions. (PMCID: PMC7680455; PMID: 32916312)
`340. L. T. Lepovitz, A. R. Meis, S. M. Thomas, J. Wiedeman, A. Pham, K. Mensa-Wilmot, and S. F.
`Martin, Tetrahedron 2020, 76:131086. Design, synthesis, and evaluation of novel anti-
`trypanosomal compounds.
`339. R. M. Wypych, S. R. LaPlante, P. W. White, and S. F. Martin Eur. J. Med. Chem. 2020,
`192:112195. Structure-Thermodynamics Relationships of Hepatitis C Viral NS3 Protease
`Inhibitors.
`338. A. M. Goodnough, J. J. Sahn, and S. F. Martin Tetrahedron Lett. 2020, 61:151777. Facile Entry
`to Substituted 2-Arylpiperidines via an Aza-Sakurai Reaction.
`337. M. D. Wood, D. W. Klosowski, and S. F. Martin Org. Lett. 2020, 22, 786. Stereoselective
`Synthesis of (±)-Alstoscholarisine E.
`336. L. T. Lepovitz and S. F. Martin, Tetrahedron 2019, 75:130637. Diversity-Oriented Synthesis of
`Bioactive Azaspirocycles.
` E Vázquez-Rosa, M. R. Watson, J. J. Sahn, T. R. Hodges, R. E. Schroeder, C. J. Cintrón-Pérez,
`M.-K. Shin, T. C. Yin, J. L. Emery, S. F. Martin, D. J. Liebl, A. A. Pieper, ACS Chem. Neurosci.
`(DKR-1677) after Traumatic Brain Injury.
`334. L. T. Lepovitz and S. F. Martin, Org. Lett. 2018, 20, 7875. Biomimetically-Inspired Synthesis of
`Exotine A. Among top ten downloaded articles for December 2018.
`333. S. Blumberg and S. F. Martin, Tetrahedron, 2018, 74, 4981. "Toward the Total Synthesis of
`Citreamicin h: Synthesis of the Pentacyclic Core and GAB-Ring Annelation Model Studies."
`332. C. Dockendorff, D. Gandhi, I. H. Kimball, K. S. Eum, R. Rusinova, H. Ingolfsson, R. Kapoor, T.
`Peyear, M. W. Dodge, S. F. Martin, R. W. Aldrich, O. S. Andersen, J. T. Sack, Biochemistry,
`2018, 57, 2733. "Synthetic analogs of the snail toxin 6-bromo-2-mercaptotryptamine dimer
`(BrMT) reveal that lipid bilayer perturbation does not underlie its modulation of voltage-gated
`potassium channels."
`331. D. W. Klosowski, J. C. Hethcox, D. H. Paull, C. Fang, J. R. Donald, C. R. Shugrue, A. D.
`Pansick, and S. F. Martin, J. Org. Chem. 2018, 83, 5954. “Enantioselective Halolactonization
`Reactions using BINOL-derived Bifunctional Catalysts: Methodology, Diversification, and
`Applications." (Highlighted in SYNFACTS 2018, 790)
`330. T. R. Hodges, N. Benjamin, S. F. Martin, Tetrahedron 2018 74, 3329. "Concise Approach to the
`Syntheses of (±)-Gliocladin C and Related Diketopiperazine Alkaloids."
`329. K. Linkens, H. R. Schmidt, J. J. Sahn, A. C. Kruse, and S. F. Martin, Eur. J. Med. Chem. 2018,
`151, 557. "Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds
`for their sigma receptor binding properties."
`328. D. W. Klosowski and S. F. Martin Org Lett. 2018, 20, 1269. “Synthesis of (+)-Disparlure via
`Enantioselective Iodolactonization.”
`327. L. L. Scott, J. J. Sahn, A. Ferragud, R. C. Yen, P. N. Satarasingh, M. D. Wood, T. R. Hodges, T.
`Shi, B. A. Prakash, K. M. Friese, A. Shen, J. T. Pierce, V. Sabino, S. F. Martin,
`Neuropsychopharmacology, 2018, 43, 1867. "Novel small molecule modulator of s2R/Tmem97
`reduces alcohol withdrawal-induced behaviors."
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`326. D. W. Klosowski and S. F. Martin, SynLett, 2018, 29, 430. “Synthesis of Enantioenriched
`Cyclohexene Fragments for Kibdelone C.” (invited paper). Featured on cover of special issue of
`journal.
`325. E. Ghanem, S. Long, S. Rodenbusch, R. Shear, J. Beckham, K. Procko, L. DePue, K. Stevenson,
`J. Robertus, S. Martin, B. Holliday, R. A. Jones, E. Anslyn, S. Simmons, J. Chem. Ed. 2018, 95,
`248. "Teaching through Research: Alignment of Core Chemistry Competencies and Skills within
`a Multidisciplinary Research Framework".
`324. S. Mondal, E. Hegarty, J. J. Sahn, L. L. Scott, S. K. Gökçe, C. Martin, N. Ghorashian, P. N.
`Satarasinghe, S. Iyer, W. Sae-Lee, T. R. Hodges, J. T. Pierce, S. F. Martin, and A. Ben-Yakar,
`ACS Chem. Neurosci. 2018, 9, 1014. High-Content Microfluidic Screening Platform Used To
`Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C.
`elegans SC_APP Model."
`323. S. F. Martin, "Natural Products and Their Mimics as Targets of Opportunity for Discovery." J.
`Org. Chem. 2017, 82, 10757. Featured as ACS Editor's Choice article for 2017.
`322. C. Dockendorff, D. Gandhi, I, Kimball, K. S. Eum, R. Rusinova, H. Ingolfsson, R. Kapoor, T.
`Peyear, S. F. Martin, R. W. Aldrich, O. S. Andersen, J. Sack, Biophys. J. 2017, 112, 246A-
`247A. "Lipid Bilayer Perturbation by the Snail Toxin 6-Bromo-2-Mercaptotryptamine Dimer
`does not Account for its Modulation of Voltage-Gated Potassium Channels."
`J. J. Sahn, G. L. Mejia, P. R. Ray, S. F. Martin, T. J. Price, ACS Chem. Neurosci. 2017, 8, 1801.
`"Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in
`Mice." Featured in multiple news highlights: See Pharmafocus, September 2017, Vol 19 (7), p 8.
`320. A. Alon, H. R. Schmidt, M. D. Wood, J. J. Sahn, S. F. Martin, A. C. Kruse, Proc. Natl. Acad. Sci
`(USA), 2017, 114, 7160. "Identification of the gene that codes for the σ2 receptor." Featured in
`PNAS Commentary: Proc. Natl. Acad. Sci (USA), 2017, 114, 6888.
`319. T. R. Hodges, N. Benjamin, S. F. Martin, Org. Lett. 2017, 19, 2254. "Synthesis of Gliocladin C
`and Related Alkaloids."
`318. R. Yu, X. Chen, S. F. Martin, and Z. Wang, Org. Lett. 2017, 19, 1808. “Differentially Substituted
`Phosphines via Decarbonylation of Acylphosphines.”
`J. J. Sahn, T. R. Hodges, and S. F. Martin, ACS Med. Chem. Lett. 2017, 8, 455.
`"Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype
`Selectivity."
`316. S. Blumberg and S. F. Martin, Org. Lett. 2017, 19, 790. "Synthesis of the pentacyclic core of
`citreamicin h."
`315. B. Yi, J. J. Sahn, P. M. Ardestania, A. K. Evans, L. Scott, J. Z. Chan, S. Iyer, A. Crisp, G.
`Zuniga, J. Pierce-Shimomura, S. F. Martin, M. Shamloo, J. Neurochem 2017, 140, 561doi:
`10.1111/jnc.13917. "Small molecule modulator of sigma 2 receptor is neuroprotective and
`reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer’s
`disease."
`J. J. Sahn, T. Hodges, J. Chan, and S. F. Martin ChemMedChem 2016, 11, 556.
`"Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Subtype Selective
`Ligands."
`313. B. Cheng, J. D. Sunderhaus, and S. F. Martin Tetrahedron 2015, 71, 7323. "Applications of Ring
`Closing Metathesis. Total Synthesis of (±)-Pseudotabersonine." (invited paper)
`J. C. Hethcox, C. S Shanahan, and S. F. Martin, Tetrahedron 2015, 71, 6361. "Diastereoselective
`addition of monoorganocuprates to a chiral fumarate: reaction development and application to
`natural product synthesis." (invited paper)
`311. D. Knueppel, J. Yang, B. Cheng, D. Mans, and S. F. Martin, Tetrahedron 2015, 71, 5741. "Total
`Synthesis of the Aglycone of IB-00208." (invited paper)
`310. S. Blumberg and S. F. Martin Tetrahedron Lett. 2015, 56, 3674. "4-(Phenylazo)diphenylamine
`(PDA): A universal indicator for the colorimetric titration of strong bases, Lewis acids, and
`hydride reducing agents." (invited paper)
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`J. Yang, D. Knueppel, B. Cheng, D. Mans, and S. F. Martin, Org. Lett. 2015, 17, 114.
`"Approaches to Polycyclic 1,4-Dioxygenated Xanthones. Application to Total Synthesis of the
`Aglycone of IB-00208."
`308. Z. Bian, C. C. Marvin, M. Pettersson, and S. F. Martin, J. Am. Chem. Soc. 2014, 136, 14184.
`"Enantioselective Total Syntheses of Citrinadins A and B. Stereochemical Revision of their
`Assigned Structures."
`307. S. Hardy and S. F. Martin, Tetrahedron 2014, 70, 7142. "Multicomponent, Mannich-type
`assembly process for generating novel, biologically active 2-arylpiperidines and derivatives."
`J. J. Sahn, B. A. Granger, and S. F. Martin Org. Biomol. Chem. 2014, 12, 7659. "Evolution of a
`Strategy for Preparing Bioactive Small Molecules by Sequential Multicomponent Assembly
`Processes, Cyclizations, and Diversification."
`J. M. Myslinski, J. H. Clements, and S. F. Martin, Biorg. Med. Chem. Lett. 2014, 24, 3164.
`"Protein-Ligand Interactions: Probing the Energetics of a Putative Cation-π Interaction."
`304. B. A. Granger, I. T. Jewett, J. D. Butler, and S. F. Martin, Tetrahedron 2014, 70, 4094. "Concise
`Total Synthesis of (±)-Actinophyllic Acid."
`303. S. F. Martin, Adv. Heterocyclic Chem. 2013, 110, 73. "Strategies for the Synthesis of Alkaloids
`and Novel Nitrogen Heterocycles."
`J. M. Myslinski, J. H. Clements, J. E. DeLorbe, and S. F. Martin ACS Med Chem Lett. 2013, 4,
`1048. "Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing the
`Length of an Alkyl Chain."
`301. B. A. Granger, Z. Wang, K. Kaneda, Z. Fang, and S. F. Martin ACS Combi. Sci. 2013, 15, 379.
`"Multicomponent Assembly Processes for the Synthesis of Diverse Yohimbine and Corynanthe
`Alkaloid Analogs."
`300. B. A. Granger, I. T. Jewett, J. D. Butler, B. Hua, C. E. Knezevic, E. I. Parkinson, P. J.
`Hergenrother, and S. F. Martin, J. Am. Chem. Soc. 2013, 135, 12984. "Synthesis of (±)-
`Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total
`Synthesis."
`299. Z. Bian, C. C. Marvin, and S. F. Martin, J. Am. Chem. Soc. 2013, 135, 10886. "Enantioselective
`Total Synthesis of (–)-Citrinadin A and Revision of its Stereochemical Structure." (Highlighted
`in C&EN, July 29, 2013, p 28; vol 91, issue 30)
`298. C. S. Shanahan, C. Fang, N. O. Fuller, J. Dietz, B. Ludolph, D. H. Paull, and S. F. Martin,
`Tetrahedron 2013, 69, 7592. "The Evolution of a Dipolar Cycloaddition Strategy as Applied to
`an Asymmetric Formal Total Synthesis of the Stemofoline Alkaloids."
`297. T.-H. Fu, W. T. McElroy, M. Shamszad, R. W. Heidebrecht, Jr., B. Gulledge, and S. F. Martin,
`Tetrahedron 2013, 69, 5588. "Studies toward welwitindolinones: Formal syntheses of N-
`methylwelwitindolinone C isothiocyanate and related natural products."
`J. C. Hethcox, C. S Shanahan, and S. F. Martin, Tetrahedron Lett. 2013, 54, 2074. “Total
`Synthesis of (-)-Dihydroprotolichesterenic Acid via Asymmetric Conjugate Addition to Chiral
`Fumarates.”
`295. S. F. Martin and J. H. Clements, Annu. Rev. Biochem. 2013, 82, 267. "Correlating Energetics and
`Structure in Protein-Ligand Interactions: Paradigms and Paradoxes."
`294. C. Fang, D. H. Paull, J. C. Hethcox, C. R. Shugrue, and S. F. Martin, Org. Lett. 2012, 14, 6290.
`"Enantioselective Iodolactonizations of Disubstituted Olefinic Acids Using a Bifunctional
`Catalyst to Form Stereogenic C–I Bonds."
`293. C. Fang, C. S. Shanahan, D. H. Paull, and S. F. Martin, Angew. Chem. Int. Ed. 2012, 51, 10596.
`"Enantioselective
`Formal
`Total
`Syntheses
`of
`Didehydrostemofoline
`and
`Isodidehydrostemofoline via a Novel Catalytic Dipolar Cycloaddition Cascade." (Highlighted in
`SYNFACTS 2012, 1280.)
`J. J. Sahn and S. F. Martin, ACS Combi. Sci. 2012, 14, 496. "Expedient Synthesis of
`Norbenzomorphan Library via Multicomponent Assembly Process Coupled with Ring-Closing
`Reactions." (Most read article of Q3 2012 in ACS Combi. Sci.)
`
`296.
`
`292.
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`5
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`

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`288.
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`283.
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`282.
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`285.
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`291. T.-h. Fu, W. T. McElroy, M. Shamszad, and S. F. Martin Org. Lett. 2012, 14, 3834. "Formal
`Syntheses of Naturally Occurring Welwitindolinones."
`290. D. H. Paull, C. Fang, J. R. Donald, A. D. Pansick, and S. F. Martin, J. Am. Chem. Soc. 2012,
`134, 11129. "Bifunctional Catalyst Promotes Highly Enantioselective Bromolactonizations to
`Generate Stereogenic C–Br Bonds." (Highlighted in C&EN, July 9, 2012, p 29; vol 90, issue 28)
`289. A. L. Nichols, P. Zhang, and S. F. Martin, Tetrahedron, 2012, 68, 7591. "Concise approach to
`1,4-dioxygenated Xanthones via Novel application of the Moore rearrangement."
`J. R. Donald, R. R. Wood, and S. F. Martin, ACS Combi. Sci. 2012, 14, 135." Application of a
`Sequential Multicomponent Assembly Process/Huisgen Cycloaddition Strategy
`to
`the
`Preparation of Libraries of 1,2,3-Triazole-Fused 1,4-Benzodiazepines."
`287. Y. Shi, C. Z. Zhu, S. F. Martin, and P. Ren, J. Phys. Chem. B 2012, 116, 1716. "Probing the
`Effect of Conformational Constraint on Phosphorylated Ligand Binding to SH2 Domain using
`Polarizable Force Field Simulations."
`286. B. A. Granger, K. Kaneda, and S. F. Martin, ACS Combi Sci. 2012, 14, 75. "Libraries of
`2,3,4,6,7,11b-Hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine
`Derivatives
`via
`a
`Multicomponent Assembly Process/1,3-Dipolar Cycloaddition Strategy."
`J. Donald, B. Granger, S. Hardy, J. Sahn and S. F. Martin, Heterocycles 2012, 84, 1089
`"Applications of Multicomponent Assembly Processes to the Facile Syntheses of Diversely
`Functionalized Nitrogen Heterocycles."
`284. Z. Wang, K. Kaneda, Z. Fang, and S. F. Martin, Tetrahedron Lett. 2012, 53, 477. “Diversity
`Oriented Synthesis: Concise Entry to Novel Derivatives of the Yohimbine and Corynanthe
`Alkaloids.”
`J. M. Myslinski, J. E. DeLorbe, J. H. Clements, and S. F. Martin, J. Am. Chem. Soc. 2011, 133,
`18518. "Protein-Ligand Interactions: Thermodynamic Effects of Increasing Nonpolar Surface
`Area."
`J. J. Sahn and S. F. Martin, Tetrahedron Lett. 2011, 52, 6855. “Facile Syntheses of Substituted,
`Conformationally-Constrained Benzoxazocines
`and Benzazocines
`via
`Sequential
`Multicomponent Assembly and Cyclization.”
`281. D. Knueppel and S. F. Martin, Tetrahedron 2011, 67, 9765. "Facile Total Synthesis of
`Cribrostatin 6 and Analogs." (Highlighted in SYNFACTS 2012, 124)
`280. A. L. Nichols, P. Zhang, and S. F. Martin, Org. Lett. 2011, 13, 4696. "General and Expedient
`Synthesis of 1,4-Dioxygenated Xanthones.”
`279. B. A. Granger, K. Kaneda, and S. F. Martin, Org. Lett. 2011, 13, 4542. "Multicomponent
`Assembly Strategies for the Synthesis of Diverse Tetrahydroisoquinoline Scaffolds."
`278. B. M. O'Keefe, D. M. Mans, D. E. Kaelin, Jr., and S. F. Martin, Tetrahedron 2011, 67, 6524.
`“Studies Toward the Syntheses of Pluramycin Natural Products. The First Total Synthesis of
`Isokidamycin."
`277. C. S. Shanahan, B. Ludolf, N. Fuller and S. F. Martin, Tetrahedron Lett. 2011, 52, 4076.
`“Toward a total synthesis of the stemofoline alkaloids: Advancement of a 1,3-dipolar
`cycloaddition strategy.”
`276. S. Hardy and S. F. Martin, Org. Lett. 2011, 13, 3102. "Multicomponent Assembly and
`Diversification of Novel Heterocyclic Scaffolds Derived from 2-Arylpiperidines."
`J. J. Sahn, J. Y. Su, and S. F. Martin, Org. Lett. 2011, 13, 2590. "Facile and Unified Approach to
`Skeletally-Diverse, Privileged Scaffolds."
`274. B. M. O'Keefe, N. Simmons, and S. F. Martin, Tetrahedron, 2011, 67, 4344. "Facile Access to
`Sterically Hindered Aryl Ketones via Carbonylative Cross-Coupling: Application to the Total
`Synthesis of Luteolin."
`J. Dietz and S. F. Martin, Tetrahedron Lett. 2011, 52, 2048. "Novel Entry to the Tricyclic Core
`of Stemofoline and Didehydrostemofoline."
`J. R. Donald and S. F. Martin. "Synthesis and Diversification of 1,2,3-Triazole-Fused 1,4-
`Benzodiazepine Scaffolds." Org. Lett. 2011, 13, 852.
`6
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`275.
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`273.
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`272.
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`268.
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`265.
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`264.
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`267.
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`271. N. M. Benjamin and S. F. Martin, "Enantioselective Synthesis of 2,2,5-Tri- and 2,2,5,5-
`Tetrasubstituted Tetrahydrofurans via
`[4+2] Cycloaddition and Ring-Opening Cross-
`Metathesis." Org. Lett. 2011, 13, 450.
`270. K. Procko, H. Li, and S. F. Martin, "An Approach Toward the Total Synthesis of 5-
`Hydroxyaloin A." Org. Lett. 2010, 12, 5632.
`269. B. M. O'Keefe, D. M. Mans, D. E. Kaelin, Jr., and S. F. Martin J. Am. Chem. Soc. 2010, 132,
`15528. "Total Synthesis of Isokidamycin." (Highlighted in SYNFACTS 2011, 127)
`J. E. DeLorbe, J. H. Clements, B. B. Whiddon, and S. F. Martin, ACS Med. Chem. Lett. 2010, 1,
`448. "Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in
`Protein-Ligand Interactions."
`J. H. Clements, J. E. DeLorbe, A. P. Benfield, and S. F. Martin, Acta Cryst. 2010, D66, 1101.
`"Binding of Flexible and Constrained Ligands to the Grb2 SH2 Domain: Structural Effects of
`Ligand-Preorganization."
`266. B. Cheng, J. D. Sunderhaus, and S. F. Martin, Org. Lett. 2010, 12, 3622. "Concise Total
`Synthesis of
`(±)-Pseudotabersonine via Double Ring-Closing Metathesis Strategy."
`(Highlighted in SYNFACTS 2010, 1334)
`J. M. Ward, N. M. Gorenstein, J. Tian, S. F. Martin, and C. B. Post, J. Am. Chem. Soc. 2010,
`132, 11058. "Constraining binding hot spots: NMR and MD simulations provide a structural
`explanation for enthalpy-entropy compensation in SH2-ligand binding".
`J . A. Deck and S. F. Martin, Org. Lett. 2010, 12, 2610. "Enantioselective Synthesis of (+)-
`Isolysergol via Ring Closing Metathesis."
`263. R. W. Heidebrecht, B. Gullege, and S. F. Martin, Org. Lett. 2010, 12, 2492. "Approaches to N-
`Methylwelwitindolinone C Isothiocyanate: Facile Synthesis of the Tetracyclic Core".
`J. E. DeLorbe and S. F. Martin, Org. Lett. 2010, 12, 1576. "Concise Total Synthesis of (±)–
`Lycopladine A."
`J. H. Clements, J. E. DeLorbe, M. G. Teresk, A. P. Benfield, H. R. Plake, L. E. Millspaugh, and
`S. F. Martin, J. Am. Chem. Soc. 2009, 131, 16758. "Thermodynamic and Structural Effects of
`Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with
`Ligand-Preorganization."
`260. A. J. Smith, L. Abbott, and S. F. Martin Org. Lett. 2009, 11, 4200. "Enantioselective Conjugate
`Addition Employing 2-Heteroaryl Titanates and Zinc Reagents"
`J. D. Sunderhaus, C. Dockendorff, and S. F. Martin, Tetrahedron 2009, 65, 6454. "Synthesis of
`Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming
`Reactions."
`258. T.-H. Fu, A. Bonaparte, and S. F. Martin Tetrahedron Lett. 2009, 50, 3253. "Synthesis of b-
`Heteroaryl Propionates via Trapping of Carbocations with p-Nucleophiles."
`257. D. Knueppel and S. F. Martin, Angew. Chem. Int. Ed. 2009, 14, 2569. "Total Synthesis of
`Cribrostatin 6." (Highlighted in Nature Chem. Biol. 2009, 5, 204)
`J. D. Sunderhaus and S. F. Martin, Chem. Eur. J. 2009, 15, 1300. "Applications of
`Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds."
`255. S. Amorde, I. Jewett, A. S. Judd, and S. F. Martin, Tetrahedron 2009, 65, 3222. "Iminium Ion
`Cascade Reactions: Stereoselective Synthesis of Quinolizidines and Indolizidines."
`254. S. F. Martin, Pure Appl. Chem. 2009, 81, 195. "Recent Applications of Imines as Key
`Intermediates in the Synthesis of Alkaloids and Novel Nitrogen Heterocycles."
`253. B. M. O'Keefe, N. Simmons, and S. F. Martin, Org. Lett. 2008, 10, 5301. "Carbonylative Cross-
`Coupling of ortho-Disubstituted Aryl Iodides. Convenient Synthesis of Sterically Hindered
`Ketones."
`252. S. T. M. Simila, and S. F. Martin, Tetrahedron Lett. 2008, 49, 4501. "Applications of the Ugi
`Reaction with Ketones."
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`262.
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`261.
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`259.
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`256.
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`

`250.
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`247.
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`251. K. A. Miller, C. S. Shanahan, and S. F. Martin, Tetrahedron 2008, 64, 6884. "Pauson-Khand
`Reaction as a New Entry to the Synthesis of Bridged Bicyclic Heterocycles: Enantioselective
`Total Synthesis of (-)-Alstonerine."
`J. Davoren, C. Harcken, and S. F. Martin, J. Org. Chem. 2008, 73, 391. "Studies toward the
`Enantioselective Syntheses of Oxylipins: Total Synthesis and Structure Revision of
`Solandelactone E."
`249. B. L. Ashfeld, A. Smith, K. A. Miller, K. Tran, and S. F. Martin, J. Org. Chem. 2007, 72, 9018.
`"Features and Applications of [Rh(CO)2Cl]2-Catalyzed Alkylations of Unsymmetrical Allylic
`Substrates."
`248. M. Pettersson, D. Knueppel, and S. F. Martin, Org. Lett. 2007, 9, 4623. "Concise, Stereoselective
`Approach to the Spirooxindole Ring System of Citrinadin A."
`J. D. Sunderhaus, C. Dockendorff, and S. F. Martin, Org. Lett. 2007, 9, 4223. "Applications of
`Multicomponent Reaction for the Synthesis of Diverse Heterocyclic Scaffolds."
`246. S. T. M. Simila, and S. F. Martin J. Org. Chem. 2007, 72, 5342. "Toward the Total Synthesis of
`FR901483: Concise Synthesis of the Azatricyclic Skeleton."
`245. S. Sparks, C.-L. Chen, and S. F. Martin, Tetrahedron 2007, 63, 8619. "Tandem Intramolecular
`Benzyne-Furan Cycloadditions. Total Synthesis of Vineomycinone B2 Methyl Ester."
`244. P. Breton, P. J. Hergenrother, T. Hida, A. Hodgson, E. Kraynack, P. Kym, W.-C. Lee, M. Loft,
`A. Judd, M. Yamashita, and S. F. Martin Tetrahedron 2007, 63, 5709. "Total Synthesis of
`Erythromycin B."
`243. A. Benfield, B. Whiddon, J. H. Clements, and S. F. Martin, Arch. Biochem. Biophys. 2007, 462,
`47. "Structural and Energetic Aspects of Grb2-SH2 Domain Swapping."
`242. A. Benfield, N. M. Goodey, L. T. Phillips, and S. F. Martin, Arch. Biochem. Biophys. 2007, 460,
`41. "Structural Studies Examining the Substrate Specificity Profiles PC- PLCBc Protein
`Variants."
`241. K. A. Miller and S. F. Martin, Org. Lett. 2007, 9, 1113. "Concise, Enantioselective Total
`Synthesi