hyaluronidase PH-20 isoform 2 [Homo sapiens] Homo sapiens human 9606 1058 1058 100% 0.0 100.00 509 NP_001167515.1
`hyaluronidase PH-20 isoform X1 [Pan troglodytes] Pan troglodytes chimpanzee 9598 1046 1046 100% 0.0 99.02 509 XP_003318802.2
`hyaluronidase PH-20 isoform 1 [Homo sapiens] Homo sapiens human 9606 1031 1031 97% 0.0 100.00 511 NP_003108.2
`hyaluronidase PH-20 [Nomascus leucogenys] Nomascus leu... northern whi... 61853 1018 1018 100% 0.0 95.87 509 XP_003261317.2
`hyaluronidase PH-20 [Macaca mulatta] Macaca mulatta Rhesus monkey 9544 927 927 100% 0.0 89.41 510 XP_001086882.2
`hyaluronidase PH-20 precursor [Oryctolagus cuniculus] Oryctolagus ... rabbit 9986 717 717 96% 0.0 67.73 527 NP_001076141.2
`hyaluronidase PH-20 [Ailuropoda melanoleuca] Ailuropoda m... giant panda 9646 696 696 92% 0.0 67.30 540 XP_002919069.1
`hyaluronidase PH-20 [Sus scrofa] Sus scrofa pig 9823 682 682 92% 0.0 65.88 493 NP_999176.1
`hyaluronidase PH-20 [Bos taurus] Bos taurus cattle 9913 680 680 91% 0.0 66.24 550 XP_002686960.3
`sperm adhesion molecule 1 precursor [Bos taurus] Bos taurus cattle 9913 653 653 96% 0.0 61.68 553 NP_001008413.3
`hyaluronidase-5-like [Cricetulus griseus] Cricetulus g... Chinese hamster 10029 649 649 92% 0.0 62.34 526 XP_003502178.1
`hyaluronidase PH-20 precursor [Cavia porcellus] Cavia porcellus domestic gui... 10141 646 646 94% 0.0 60.04 529 NP_001166492.1
`hyaluronidase PH-20 [Rattus norvegicus] Rattus norve... Norway rat 10116 631 631 92% 0.0 61.57 526 NP_001019492.1
`hyaluronidase PH-20 [Ornithorhynchus anatinus] Ornithorhync... platypus 9258 588 588 94% 0.0 57.56 604 XP_001507937.2
`hyaluronidase PH-20 precursor [Mus musculus] Mus musculus house mouse 10090 586 586 92% 0.0 58.05 512 NP_001073344.1
`hyaluronidase PH-20 precursor [Rattus norvegicus] Rattus norve... Norway rat 10116 565 565 92% 0.0 55.30 512 NP_446419.1
`hyaluronidase PH-20 [Cricetulus griseus] Cricetulus g... Chinese hamster 10029 562 562 92% 0.0 55.18 513 XP_003502177.1
`hyaluronidase PH-20 [Taeniopygia guttata] Taeniopygia ... zebra finch 59729 538 538 87% 0.0 54.44 586 XP_002190553.4
`hyaluronidase PH-20 [Xenopus tropicalis] Xenopus trop... tropical cla... 8364 450 450 91% 3e-150 46.09 526 XP_002932242.3
`sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida... Xenopus laevis African claw... 8355 436 436 90% 3e-145 45.84 512 NP_001082194.1
`hyaluronidase-4 [Ailuropoda melanoleuca] Ailuropoda m... giant panda 9646 409 409 89% 8e-135 44.57 481 XP_002919077.1
`hyaluronidase-4 [Oryctolagus cuniculus] Oryctolagus ... rabbit 9986 408 408 81% 2e-134 47.73 484 XP_002712114.1
`LOW QUALITY PROTEIN: hyaluronidase-4 [Canis lupus familiaris] Canis lupus ... dog 9615 408 408 85% 2e-134 45.77 489 XP_532444.4
`hyaluronidase-4 [Pongo abelii] Pongo abelii Sumatran ora... 9601 404 404 81% 4e-133 47.49 481 XP_002818436.2
`hyaluronidase-4 [Mus musculus] Mus musculus house mouse 10090 404 404 80% 5e-133 45.87 481 NP_084124.1
`hyaluronidase-4 isoform X2 [Sus scrofa] Sus scrofa pig 9823 402 402 85% 2e-132 44.62 482 XP_003134772.2
`hyaluronidase-4 [Homo sapiens] Homo sapiens human 9606 402 402 81% 4e-132 47.26 481 NP_036401.2
`hyaluronidase-4 [Nomascus leucogenys] Nomascus leu... northern whi... 61853 400 400 89% 2e-131 44.35 481 XP_003261316.2
`hyaluronidase-4 [Loxodonta africana] Loxodonta af... African sava... 9785 400 400 85% 2e-131 45.18 481 XP_003407292.1
`hyaluronidase-4 [Bos taurus] Bos taurus cattle 9913 398 398 85% 1e-130 44.62 481 XP_003586042.1
`hyaluronidase-4 [Rattus norvegicus] Rattus norve... Norway rat 10116 392 392 86% 2e-128 42.08 481 NP_001094250.1
`hyaluronidase-4 [Anolis carolinensis] Anolis carol... green anole 28377 387 387 81% 5e-127 44.98 447 XP_003221368.2
`hyaluronidase-4 [Cavia porcellus] Cavia porcellus domestic gui... 10141 385 385 87% 2e-125 43.24 486 XP_003475093.1
`hyaluronidase-4 [Xenopus tropicalis] Xenopus trop... tropical cla... 8364 375 375 77% 7e-122 46.27 462 NP_001090796.1
`hyaluronidase [Anolis carolinensis] Anolis carol... green anole 28377 373 373 79% 2e-121 45.83 445 XP_003221369.1
`hyaluronidase-4 [Oreochromis niloticus] Oreochromis ... Nile tilapia 8128 364 364 85% 6e-117 40.32 515 XP_003449274.1
`hyaluronoglucosaminidase 6 [Danio rerio] Danio rerio zebrafish 7955 361 361 77% 3e-116 44.80 486 NP_001074140.1
`hyaluronidase-2 [Anolis carolinensis] Anolis carol... green anole 28377 359 359 79% 2e-115 44.12 474 XP_003217669.1
`hyaluronidase-4 [Ornithorhynchus anatinus] Ornithorhync... platypus 9258 358 358 82% 3e-115 42.28 484 XP_001507903.3
`hyaluronidase [Oreochromis niloticus] Oreochromis ... Nile tilapia 8128 358 358 78% 8e-115 44.69 499 XP_003449275.2
`hyaluronidase-2 [Monodelphis domestica] Monodelphis ... gray short-t... 13616 357 357 78% 1e-114 44.58 478 XP_001378617.3
`hyaluronidase-2 [Meleagris gallopavo] Meleagris ga... turkey 9103 356 356 80% 1e-114 44.58 454 XP_003210019.2
`hyaluronidase 2 L homeolog precursor [Xenopus laevis] Xenopus laevis African claw... 8355 356 356 80% 3e-114 42.92 474 NP_001165445.1
`hyaluronidase-2 isoform X1 [Gallus gallus] Gallus gallus chicken 9031 356 356 82% 4e-114 43.44 478 XP_414258.3
`hyaluronidase 2 S homeolog precursor [Xenopus laevis] Xenopus laevis African claw... 8355 356 356 77% 4e-114 45.19 487 NP_001080777.1
`hyaluronidase-2 precursor [Xenopus tropicalis] Xenopus trop... tropical cla... 8364 355 355 85% 9e-114 43.12 478 NP_001119986.1
`hyaluronidase PH-20-like [Cricetulus griseus] Cricetulus g... Chinese hamster 10029 343 343 52% 2e-112 59.02 270 XP_003509213.1
`hyaluronidase-1 [Anolis carolinensis] Anolis carol... green anole 28377 350 350 81% 3e-112 43.47 443 XP_003221370.3
`hyaluronidase-2 [Oreochromis niloticus] Oreochromis ... Nile tilapia 8128 350 350 81% 5e-112 43.13 470 XP_003448364.1
`hyaluronidase-1 [Taeniopygia guttata] Taeniopygia ... zebra finch 59729 348 348 77% 2e-111 45.52 469 XP_002189602.4
`hyaluronidase PH-20 precursor [Danio rerio] Danio rerio zebrafish 7955 343 343 77% 1e-109 42.82 439 NP_001074154.2
`hyaluronidase-1 isoform X1 [Oreochromis niloticus] Oreochromis ... Nile tilapia 8128 343 343 83% 2e-109 40.14 462 XP_003448436.2
`hyaluronidase-2 [Pongo abelii] Pongo abelii Sumatran ora... 9601 340 340 82% 3e-108 39.76 473 XP_002813763.3
`hyaluronidase-1 [Xenopus tropicalis] Xenopus trop... tropical cla... 8364 338 338 81% 1e-107 43.36 438 XP_002935681.1
`hyaluronidase-2 [Pan troglodytes] Pan troglodytes chimpanzee 9598 338 338 82% 2e-107 39.76 473 XP_001168599.1
`hyaluronidase-2 isoform X1 [Danio rerio] Danio rerio zebrafish 7955 338 338 87% 4e-107 38.86 502 XP_687640.2
`
`Petitioner Merck, Ex. 1054, p. 1
`
`
`hyaluronidase PH-20 isoform X1 [Pan troglodytes] Pan troglodytes chimpanzee 9598 1046 1046 100% 0.0 99.02 509 XP_003318802.2
`hyaluronidase PH-20 isoform 1 [Homo sapiens] Homo sapiens human 9606 1031 1031 97% 0.0 100.00 511 NP_003108.2
`hyaluronidase PH-20 [Nomascus leucogenys] Nomascus leu... northern whi... 61853 1018 1018 100% 0.0 95.87 509 XP_003261317.2
`hyaluronidase PH-20 [Macaca mulatta] Macaca mulatta Rhesus monkey 9544 927 927 100% 0.0 89.41 510 XP_001086882.2
`hyaluronidase PH-20 precursor [Oryctolagus cuniculus] Oryctolagus ... rabbit 9986 717 717 96% 0.0 67.73 527 NP_001076141.2
`hyaluronidase PH-20 [Ailuropoda melanoleuca] Ailuropoda m... giant panda 9646 696 696 92% 0.0 67.30 540 XP_002919069.1
`hyaluronidase PH-20 [Sus scrofa] Sus scrofa pig 9823 682 682 92% 0.0 65.88 493 NP_999176.1
`hyaluronidase PH-20 [Bos taurus] Bos taurus cattle 9913 680 680 91% 0.0 66.24 550 XP_002686960.3
`sperm adhesion molecule 1 precursor [Bos taurus] Bos taurus cattle 9913 653 653 96% 0.0 61.68 553 NP_001008413.3
`hyaluronidase-5-like [Cricetulus griseus] Cricetulus g... Chinese hamster 10029 649 649 92% 0.0 62.34 526 XP_003502178.1
`hyaluronidase PH-20 precursor [Cavia porcellus] Cavia porcellus domestic gui... 10141 646 646 94% 0.0 60.04 529 NP_001166492.1
`hyaluronidase PH-20 [Rattus norvegicus] Rattus norve... Norway rat 10116 631 631 92% 0.0 61.57 526 NP_001019492.1
`hyaluronidase PH-20 [Ornithorhynchus anatinus] Ornithorhync... platypus 9258 588 588 94% 0.0 57.56 604 XP_001507937.2
`hyaluronidase PH-20 precursor [Mus musculus] Mus musculus house mouse 10090 586 586 92% 0.0 58.05 512 NP_001073344.1
`hyaluronidase PH-20 precursor [Rattus norvegicus] Rattus norve... Norway rat 10116 565 565 92% 0.0 55.30 512 NP_446419.1
`hyaluronidase PH-20 [Cricetulus griseus] Cricetulus g... Chinese hamster 10029 562 562 92% 0.0 55.18 513 XP_003502177.1
`hyaluronidase PH-20 [Taeniopygia guttata] Taeniopygia ... zebra finch 59729 538 538 87% 0.0 54.44 586 XP_002190553.4
`hyaluronidase PH-20 [Xenopus tropicalis] Xenopus trop... tropical cla... 8364 450 450 91% 3e-150 46.09 526 XP_002932242.3
`sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida... Xenopus laevis African claw... 8355 436 436 90% 3e-145 45.84 512 NP_001082194.1
`hyaluronidase-4 [Ailuropoda melanoleuca] Ailuropoda m... giant panda 9646 409 409 89% 8e-135 44.57 481 XP_002919077.1
`hyaluronidase-4 [Oryctolagus cuniculus] Oryctolagus ... rabbit 9986 408 408 81% 2e-134 47.73 484 XP_002712114.1
`LOW QUALITY PROTEIN: hyaluronidase-4 [Canis lupus familiaris] Canis lupus ... dog 9615 408 408 85% 2e-134 45.77 489 XP_532444.4
`hyaluronidase-4 [Pongo abelii] Pongo abelii Sumatran ora... 9601 404 404 81% 4e-133 47.49 481 XP_002818436.2
`hyaluronidase-4 [Mus musculus] Mus musculus house mouse 10090 404 404 80% 5e-133 45.87 481 NP_084124.1
`hyaluronidase-4 isoform X2 [Sus scrofa] Sus scrofa pig 9823 402 402 85% 2e-132 44.62 482 XP_003134772.2
`hyaluronidase-4 [Homo sapiens] Homo sapiens human 9606 402 402 81% 4e-132 47.26 481 NP_036401.2
`hyaluronidase-4 [Nomascus leucogenys] Nomascus leu... northern whi... 61853 400 400 89% 2e-131 44.35 481 XP_003261316.2
`hyaluronidase-4 [Loxodonta africana] Loxodonta af... African sava... 9785 400 400 85% 2e-131 45.18 481 XP_003407292.1
`hyaluronidase-4 [Bos taurus] Bos taurus cattle 9913 398 398 85% 1e-130 44.62 481 XP_003586042.1
`hyaluronidase-4 [Rattus norvegicus] Rattus norve... Norway rat 10116 392 392 86% 2e-128 42.08 481 NP_001094250.1
`hyaluronidase-4 [Anolis carolinensis] Anolis carol... green anole 28377 387 387 81% 5e-127 44.98 447 XP_003221368.2
`hyaluronidase-4 [Cavia porcellus] Cavia porcellus domestic gui... 10141 385 385 87% 2e-125 43.24 486 XP_003475093.1
`hyaluronidase-4 [Xenopus tropicalis] Xenopus trop... tropical cla... 8364 375 375 77% 7e-122 46.27 462 NP_001090796.1
`hyaluronidase [Anolis carolinensis] Anolis carol... green anole 28377 373 373 79% 2e-121 45.83 445 XP_003221369.1
`hyaluronidase-4 [Oreochromis niloticus] Oreochromis ... Nile tilapia 8128 364 364 85% 6e-117 40.32 515 XP_003449274.1
`hyaluronoglucosaminidase 6 [Danio rerio] Danio rerio zebrafish 7955 361 361 77% 3e-116 44.80 486 NP_001074140.1
`hyaluronidase-2 [Anolis carolinensis] Anolis carol... green anole 28377 359 359 79% 2e-115 44.12 474 XP_003217669.1
`hyaluronidase-4 [Ornithorhynchus anatinus] Ornithorhync... platypus 9258 358 358 82% 3e-115 42.28 484 XP_001507903.3
`hyaluronidase [Oreochromis niloticus] Oreochromis ... Nile tilapia 8128 358 358 78% 8e-115 44.69 499 XP_003449275.2
`hyaluronidase-2 [Monodelphis domestica] Monodelphis ... gray short-t... 13616 357 357 78% 1e-114 44.58 478 XP_001378617.3
`hyaluronidase-2 [Meleagris gallopavo] Meleagris ga... turkey 9103 356 356 80% 1e-114 44.58 454 XP_003210019.2
`hyaluronidase 2 L homeolog precursor [Xenopus laevis] Xenopus laevis African claw... 8355 356 356 80% 3e-114 42.92 474 NP_001165445.1
`hyaluronidase-2 isoform X1 [Gallus gallus] Gallus gallus chicken 9031 356 356 82% 4e-114 43.44 478 XP_414258.3
`hyaluronidase 2 S homeolog precursor [Xenopus laevis] Xenopus laevis African claw... 8355 356 356 77% 4e-114 45.19 487 NP_001080777.1
`hyaluronidase-2 precursor [Xenopus tropicalis] Xenopus trop... tropical cla... 8364 355 355 85% 9e-114 43.12 478 NP_001119986.1
`hyaluronidase PH-20-like [Cricetulus griseus] Cricetulus g... Chinese hamster 10029 343 343 52% 2e-112 59.02 270 XP_003509213.1
`hyaluronidase-1 [Anolis carolinensis] Anolis carol... green anole 28377 350 350 81% 3e-112 43.47 443 XP_003221370.3
`hyaluronidase-2 [Oreochromis niloticus] Oreochromis ... Nile tilapia 8128 350 350 81% 5e-112 43.13 470 XP_003448364.1
`hyaluronidase-1 [Taeniopygia guttata] Taeniopygia ... zebra finch 59729 348 348 77% 2e-111 45.52 469 XP_002189602.4
`hyaluronidase PH-20 precursor [Danio rerio] Danio rerio zebrafish 7955 343 343 77% 1e-109 42.82 439 NP_001074154.2
`hyaluronidase-1 isoform X1 [Oreochromis niloticus] Oreochromis ... Nile tilapia 8128 343 343 83% 2e-109 40.14 462 XP_003448436.2
`hyaluronidase-2 [Pongo abelii] Pongo abelii Sumatran ora... 9601 340 340 82% 3e-108 39.76 473 XP_002813763.3
`hyaluronidase-1 [Xenopus tropicalis] Xenopus trop... tropical cla... 8364 338 338 81% 1e-107 43.36 438 XP_002935681.1
`hyaluronidase-2 [Pan troglodytes] Pan troglodytes chimpanzee 9598 338 338 82% 2e-107 39.76 473 XP_001168599.1
`hyaluronidase-2 isoform X1 [Danio rerio] Danio rerio zebrafish 7955 338 338 87% 4e-107 38.86 502 XP_687640.2
`
`Petitioner Merck, Ex. 1054, p. 1
`
`
`
`hyaluronidase-2 precursor [Homo sapiens] Homo sapiens human 9606 337 337 82% 5e-107 39.53 473 NP_003764.3
`hyaluronidase-2 [Cavia porcellus] Cavia porcellus domestic gui... 10141 337 337 82% 6e-107 39.68 471 XP_003476739.1
`hyaluronidase-2 [Nomascus leucogenys] Nomascus leu... northern whi... 61853 337 337 82% 8e-107 39.53 473 XP_003257153.1
`hyaluronidase-2 [Callithrix jacchus] Callithrix j... white-tufted... 9483 334 334 80% 6e-106 39.71 473 XP_002758427.1
`hyaluronidase-1 isoform X1 [Macaca mulatta] Macaca mulatta Rhesus monkey 9544 332 332 79% 2e-105 41.26 450 XP_001102414.2
`hyaluronidase-2 precursor [Rattus norvegicus] Rattus norve... Norway rat 10116 331 331 78% 1e-104 41.13 473 NP_742037.2
`hyaluronidase-2 precursor [Sus scrofa] Sus scrofa pig 9823 328 328 80% 1e-103 40.14 476 NP_999605.1
`hyaluronidase-2 precursor [Ovis aries] Ovis aries sheep 9940 327 327 80% 4e-103 39.67 476 NP_001009754.1
`hyaluronoglucosaminidase 6 precursor [Mus musculus] Mus musculus house mouse 10090 327 327 81% 6e-103 40.86 494 NP_083196.2
`hyaluronoglucosaminidase 6 precursor [Rattus norvegicus] Rattus norve... Norway rat 10116 326 326 78% 1e-102 42.43 481 NP_001019491.1
`hyaluronidase-2 precursor [Bos taurus] Bos taurus cattle 9913 325 325 80% 3e-102 39.43 473 NP_776772.1
`hyaluronidase-1 isoform 1 precursor [Homo sapiens] Homo sapiens human 9606 320 320 80% 1e-100 41.57 435 NP_149349.2
`hyaluronidase-1 precursor [Danio rerio] Danio rerio zebrafish 7955 319 319 77% 3e-100 41.12 449 NP_001035086.1
`hyaluronidase-like [Cricetulus griseus] Cricetulus g... Chinese hamster 10029 320 320 83% 5e-100 39.95 486 XP_003502176.1
`hyaluronidase-1 [Nomascus leucogenys] Nomascus leu... northern whi... 61853 317 317 79% 2e-99 41.02 435 XP_003257149.1
`hyaluronidase-1 isoform X1 [Pongo abelii] Pongo abelii Sumatran ora... 9601 316 316 79% 3e-99 40.78 435 XP_002813766.6
`hyaluronidase-1 precursor [Bos taurus] Bos taurus cattle 9913 315 315 80% 7e-99 41.33 450 NP_001017941.1
`hyaluronidase-2 isoform X3 [Ailuropoda melanoleuca] Ailuropoda m... giant panda 9646 315 315 77% 2e-98 41.50 450 XP_002920567.1
`hyaluronidase-1 isoform X1 [Cavia porcellus] Cavia porcellus domestic gui... 10141 314 314 77% 2e-98 42.64 449 XP_003476738.1
`hyaluronidase-1 precursor [Sus scrofa] Sus scrofa pig 9823 313 313 80% 3e-98 41.57 435 NP_999606.1
`hyaluronidase PH-20-like [Cricetulus griseus] Cricetulus g... Chinese hamster 10029 303 303 46% 3e-97 58.65 243 XP_003516131.1
`hyaluronidase-1 isoform X1 [Oryctolagus cuniculus] Oryctolagus ... rabbit 9986 311 311 77% 2e-96 41.35 497 XP_002713406.3
`hyaluronidase-1 [Cricetulus griseus] Cricetulus g... Chinese hamster 10029 307 307 77% 2e-95 41.54 463 XP_003500449.1
`hyaluronidase-1 [Ornithorhynchus anatinus] Ornithorhync... platypus 9258 301 301 77% 2e-93 40.00 442 XP_001509131.1
`hyaluronidase-4-like [Pan troglodytes] Pan troglodytes chimpanzee 9598 301 301 78% 1e-92 39.60 483 XP_001139800.4
`hyaluronidase-1 isoform 1 precursor [Mus musculus] Mus musculus house mouse 10090 296 296 77% 1e-91 40.50 449 NP_032343.3
`hyaluronidase-1 isoform 1 precursor [Rattus norvegicus] Rattus norve... Norway rat 10116 296 296 79% 2e-91 39.66 449 NP_997499.2
`hyaluronidase-1 isoform X2 [Macaca mulatta] Macaca mulatta Rhesus monkey 9544 291 291 79% 5e-90 38.35 420 XP_001102322.2
`hyaluronidase-1 isoform 2 precursor [Homo sapiens] Homo sapiens human 9606 280 280 80% 2e-85 38.72 405 NP_695014.1
`hyaluronidase-1 isoform X2 [Pan troglodytes] Pan troglodytes chimpanzee 9598 278 278 82% 7e-85 37.88 405 XP_001168796.1
`hyaluronidase-3 precursor [Rattus norvegicus] Rattus norve... Norway rat 10116 278 278 75% 1e-84 38.92 412 NP_997482.2
`hyaluronidase-3 precursor [Bos taurus] Bos taurus cattle 9913 275 275 80% 2e-83 38.22 419 NP_001193181.1
`hyaluronidase-3 isoform 1 precursor [Homo sapiens] Homo sapiens human 9606 274 274 82% 3e-83 37.26 417 NP_001186958.1
`hyaluronidase-3 precursor [Sus scrofa] Sus scrofa pig 9823 274 274 70% 4e-83 40.33 419 NP_999604.1
`hyaluronidase-3 isoform X1 [Equus caballus] Equus caballus horse 9796 273 273 70% 4e-83 40.06 415 XP_001493753.3
`hyaluronidase-3 [Danio rerio] Danio rerio zebrafish 7955 273 273 78% 1e-82 39.21 428 NP_001121765.1
`hyaluronidase-3 precursor [Mus musculus] Mus musculus house mouse 10090 271 271 70% 6e-82 39.56 412 NP_821139.2
`hyaluronidase-1-like [Ciona intestinalis] Ciona intest... vase tunicate 7719 265 265 75% 1e-79 38.56 432 XP_002128103.1
`hyaluronidase-3 isoform X1 [Gallus gallus] Gallus gallus chicken 9031 263 263 70% 2e-77 39.89 561 XP_003642042.3
`
`Petitioner Merck, Ex. 1054, p. 2
`
`
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