WIPO
`
`WORLD
`INTELLECTUAL PROPERTY
`ORGANIZATION
`
`DOCUMENT MADE AVAILABLE UNDER THE
`PATENT COOPERATION TREATY (PCT)
`PCT/CN2024/108192
`International application number:
`
`International filing date:
`
`29 July 2024 (29.07.2024)
`
`Document type:
`
`Document details:
`
`Certified copy of priority document
`
`Country/Office:
`Number:
`Filing date:
`
`CN
`202311372605.9
`20 October 2023 (20.10.2023)
`
`Date of receipt at the International Bureau:
`
`09 August 2024 (09.08.2024)
`
`Remark: Priority document submitted or transmitted to the International Bureau in compliance with Rule
`17.1 (a),(b) or (b-bis)
`
`Conjupro EX1006
`Page 1 of 373
`
`

`

`Digital Access Service
`(DAS)
`
`WIPO
`WORLD
`INTELLECTUAL PROPERTY
`ORGANIZATION
`
`CERTIFICATE OF AVAILABILITY OF A CERTIFIED PATENT DOCUMENT IN A
`DIGITAL LIBRARY
`
`The International Bureau certifies that a copy of the patent application indicated
`below has been available to the WIPO Digital Access Service since the date of
`availability indicated, and that the patent application has been available to the
`indicated Office(s) as of the date specified following the relevant Office code:
`
`Document details: Country/Office: CN
`
`Filing date: 20 Oct 2023 (20.10.2023)
`
`Application number: 2023113726059
`
`Date of availability of document:
`
`09 Jul 2024 (09.07.2024)
`
`The following Offices can retrieve this document by using the access code:
`AR, AT, AU, BE, BR, CA, CL, CN, CO, CU, DK, EA, EE, EP, ES, Fl,
`GB, GE, IB, IE, IL, IN, IT, JP, KR, LT, LV, MA, MC, MX, NL, NO, NZ,
`PL, SE, US
`
`Date of issue of this certificate:
`
`09 Aug 2024 (09.08.2024)
`
`34, chemin des Colombettes
`1211 Geneva 20, Switzerland
`
`Conjupro EX1006
`Page 2 of 373
`
`

`

`NATIONAL INTELLECTUAL PROPERTY ADMINISTRATION, .PRC
`
`$
`
`ii ~: 202311372605.9
`
`~~fil~~~= -~***ffl~~~m~~~~m,~~~~~~
`&ffl
`B : 20231f.10 }=j 20 B
`~ A: ~~~~~~~~~~~~0~,tt~~~~~~
`[zf]~~~0~
`~BJ=lA~iR:it A: ~;lg§}f,
`
`2024 .1:f:. 01 ,ij 09 El
`
`Conjupro EX1006
`Page 3 of 373
`
`

`

`5
`
`ti*®!~
`*~~~r~~~~~~.A~W&-#***ffl*~~m~~w~m&~
`fffU~ 1J~tl□ $ffl o
`
`10
`
`15
`
`'ij' It ti*
`ff Pl<.m C diabetes mellitus) 'Ak-;f~11tlft!is{] r-1 '5H1Ht;iJtJ~m, El3 $;¥~ JJR I!! 51 Jm
`~W~~ffi~~$*~' $Mffffl~o~m$~. ~~*~~4.25~~MP1<.m
`~~. ~OO~ftPl<.m~m-~nl~. ~~ll~ft}JRWg~9~. WH~m$ffl
`a r~ 11□ , ,~ m if~ a ~if$£ 1i o
`§$tt~rr~MP1<.m~mffB~$~~~Lm, ~m~~•,~~~,~
`~Jfrr.ff.;t.'(:~:fc-1 (glucagon-likepeptide 1, GLP-1 )x1*~!Ji}JJfLJ, =~:t~~jcg![~(DPP-IV)
`trPfffU JfU, 'fii3-iJiJ flt1J, ~ $=~~~ E3 2 C SGLT-2) trPfffU JfU, a-fltf IDr~trPfffU JfU~, ~ ~
`GLP-1 x1*~!Ji}JJfU:ilx~tL
`GLP-1 'Ak El3A~~m L tffifflg'5H:0s{]-;f~ ~*~~!,.' ~x1*7t:1ffi=E~~~tffifflg, $
`f~ ~ ~~mtffifflg, ~*~1E!1t:£*~JtlJ-&~rmJ1E!1t:£*~JEB{]1E!1t:£5G~, GLP-1 x1*~!Ji!JFo
`20 A~~fil~~•7t~,~~~~-•7t~,~~~~~M~~n~~~~~fflo
`li{ii a iIE 1li51rroF, x1 b~ ~1teJi¥ Jfrr.ff ~ tm, GLP-1 x 1*~!Ji}J JfU A~ J!Jt B{] ~>¥ Jfrr.ff 5<"Jc!f:,
`::;f ~ ~ t±:1 tJiii 1~ Jfrr.fm~ ii Ht m O .r1t~ r ~ A~ im ~ r s,g 'L,' w 1r Y5(.@, H PJ ffexd> ~tm ti llR
`to M £1 ~ 1iF ~, ~ ,fU r 1:2 IffiJ1* !IL
`§$8LmB{] GLP-1 x1*~!Ji}JJfLJ:l:)Jn$~:k~~tm, *$rm~BCf~~. ,~
`~s{]~Ndi::;f1t, w P ~~$ ~:ts{]~tm-fUffl JlJ~ffi1~ 0 ?Jr lJ-3f ~ P ~~1J\7t-=t- GLP-1
`x 1*~!,iJJ JfU 1'¥1=Elf 1~ * s,g 111ii am* 0
`§ $ ~x 1J\7t-=f GLP-1 x1*~l,iJJJfU~Ht~. s~ 3 ~ 1J\7t-=f GLP-1 x1*~l,iJJ
`JfUfilAil1iiaWfJ"E~fr¥.i, ~□ Pifzer 0i§'J3f~B{] PF-06882961 ;f□ PF-07081532, vTv
`0i§'J3f~B{] TTP273, §$:1:)J~rli{iia 1/ll J,)j1i)fJ"E~fr¥.io ~~ PF-06882961 tl-'f.
`Jjll{iia~Ji1F71fil~B{]~fl;f□ ~1*:ffi:B{]5<"_)(:!f:, H*~·ri;f□ $Mc~ GLP-1 '.x1*~~
`$JJfUt§1bl, fJ!Jl:Jj**PJlJ-nflPl<.m, ~~~flflE, NASH ,~~w*!1!$s{]mff~1'fo
`GLP-1 '.x1*~~$JJfU1¥1=te*B{]ll1iiarm*o ~*!1! 1~. Ji[gg~-ri!l! 1!B{] P ~~1J\7t
`-=f GLP-1 '.x1*~~$J:1fU~mff $t~1-t;iJt~*ms{]~tn, A~ 11m1 s{]m:tm$1t o
`
`25
`
`30
`
`Conjupro EX1006
`Page 4 of 373
`
`

`

`*~~~§~a~m*-#~~c1)m~~~~~, ~~~#~~~~~
`"¥= __t PJ ti xJiR =
`
`(I)
`
`5
`
`R 1, R 2 ~ R 3 ~§1Etl~±-ttl!§ic :m:, ~~, ~~, 11~~, f£~, tt~, ~
`1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~ 1~;lJc~, C1-6 r£;l%~, C1-6 ;lJc~~' C1-6
`~1~;l%~~' C2-6 '.i:ffl~, C2-6 ~~' C3.s lf;l%~, 3-8 51:Jj~;Ef~, C6-10 :lY~, 5-10
`
`10
`
`15
`
`20
`
`-(CRasRbs)n4C(O)NRa9Rb9• ?!rJ£B{]~~' C1-6 ;lJc~, C1-6 m1~;lJc~, C1-6 ~1~;lJc~,
`C1-6 r£;l%~, C1-6 ;lJc~~' C1-6 ~ 1~;l%~~' C2-6 '.i:ffl~, C2-6 ~~' C3.s ;Ef ;lJc~,
`3-8 5fJj~lf~, C6-10 7'J~~ 5-10 5G*7'J~, 1fmB{]Jlt-:Wii~~, ~~, 11~~,
`f£~, It~, ~1~~' -NS(O)Ra1Rb1, C1-6 ;lJc~, C1-6 m1~;lJc~, C1-6 ~ 1~;lJc~,
`C1-6 r£;l%~, C1-6 ;lJc~~' C1-6 ~ 1~;l%~~' C2-6 '.i:ffl~, C2-6 ~~' C3.s ;Ef ;lJc~,
`3-8 5G*lf~, c6-10 7'J~~ 5-10 5G*7'J~~ s,g-~~$~llR 1~~?frllR 1~:
`
`Rbs, Ra9 ~ Rb9 ~§1Etl~±-fum§iC m, ~~' ~~' 11~~' f£~, It~, C1-6
`;lJc~, C1-6 m1~;l%~, C1-6 ~ 1~;lJc~, C1-6 r£;l%~, C1-6 ;lJc~~' C1-6 ~ 1~;l%~~'
`C2-6 '.i:ffl~, C2-6 ~~' C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :lY~~ 5-10 JG*:lY~,
`?!rJ£B{]~~ C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~1~;l%~, C1-6 r£;l%~, C1-6 ;lJc~~,
`C1-6 ~1~;l%~~' C2-6 '.i:ffl~, C2-6 ~~' C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :lY~,
`5-10 5G*7'J~, 1fms{]Jlt-:Wii~~, ~~, 11~~, r£~, It~, ~1~~,
`-NS(O)Ra1Rb1, C1-6 ;lJc~, C1-6 m1~;lJc~, C1-6 ~ 1~;lJc~, C1-6 r£;lJc~, C1-6 ;lJc~
`
`2
`
`Conjupro EX1006
`Page 5 of 373
`
`

`

`~~, Ra15f0 Rb1~Ra25f0 Rb2 ~ Ra3 5f0 Rb3 ~ Ra4 5f0 Rb4 ~ Ra6 5f0 Rb6 ~ Ras 5f0
`
`Rbs~ Ra97f0 Rb9)j-:1JiJ£5;f§~~B{]»R-1-'fJ!tf%)J¼ C3.slf:lJc~, 3-8 5G*lf~, c6-107Y
`
`5 ~~ 5-10 JG*:lY~, ?fr;£ C3.s ;Ef;tJc~, 3-8 5G*lf~, C6-10 7Y~~ 5-10 JG*:lY
`~. 1fms{]jji-:W*i ~~, ~~, 11~~, r£~, tt~, •1~~, c1-6 ;tJc~, c1-6
`m1~;tJc~, C1-6 ~ 1~;tJc~, C1-6 r£1Jc~, C1-6 ;tJc-~, C1-6 ~ 1~;tJc-~, C2-6 '.i:ffl~,
`
`10
`
`15
`
`20
`
`~ llR 1~~?frllR 1~:
`R\ Rs~ R6 ~§MLll.f-film§~, m, ~~' ~~' 11~~' r£~, It~, •
`1~~' C1-6 ;tJc~, C1-6 m1~;tJc~, C1-6 ~ 1~;tJc~, C1-6 r£1Jc~, C1-6 ;tJc-~, C1-6
`~1~;tJc-~, C2-6 '.i:ffl~, C2-6 tR:~, C3.s ;Ef;tJc~, 3-8 5G*lf~, C6-10 :lY~ 5-10
`5G*7'J~, ?!rJ£B{]~~, C1-6 ;tJc~, C1-6 m1~;tJc~, C1-6 ~1~;tJc~, C1-6 r£1%~,
`C1-6 ;tJc-~, C1-6 ~ 1~;tJc-~, C2-6 '.i:ffl~, C2-6 tR:~, C3.s ;Ef;tJc~, 3-8 5G*lf~,
`c6-10 :lY~~ 5-10 5G*7'J~, 1fms{]jji-:W*i~~, ~~, 11~~, r£~, tt~,
`-1~~' C1-6 ;tJc~, C1-6 m1~;tJc~, C1-6 ~ 1~;tJc~, C1-6 r£1Jc~, C1-6 ;tJc-~, C1-6
`~1~;tJc-~, C2-6 '.i:ffl~, C2-6 tR:~, C3.s ;Ef;tJc~, 3-8 5G*lf~, C6-10 :lY~~ 5-10
`5G*7'J~~~-~~$~llR~~mllR~:
`R7, Rs, R9 ~ R 10 ~§Mu1J-fum§~, m, ~~' ~~' 11~~' f£~, -~'
`-1~~' C1-6 ;tJc~, C1-6 m1~;tJc~, C1-6 ~ 1~;tJc~, C1-6 r£1Jc~, C1-6 ;tJc-~, C1-6
`~1~;tJc-~, C2-6 '.i:ffl~, C2-6 tR:~, C3.s ;Ef;tJc~, 3-8 5G*lf~, C6-10 :lY~ 5-10
`5G*7'J~, 1fms{]jji-:W*i~~, ~~, 11~~, r£~, tt~, •1~~, c1-61Jc~,
`C1-6 m1~;tJc~, C1-6 ~ 1~;tJc~, C1-6 r£1Jc~, C1-6 ;tJc-~, C1-6 ~ 1~;tJc-~, C2-6
`
`25
`
`~~$~1lR1~~?frllR1~:
`
`nl-n4 T'J 0-5 B{]~~;
`3 R\ R6, R9, RlOT'JEf=I~, R7, RST'J~, RST'J#C RlT'JEf=I-~, R27')#(
`at, R 3 :;f~~T'J~;
`
`3 R\ R6, R9, Rio T'JEf=I~, R7, Rs T'J~, Rs T'J#\i, R1 T'J~-0-/0H'
`R 27'JEf=l~St, R 3:;f~~T'J~;
`
`30
`
`3
`
`Conjupro EX1006
`Page 6 of 373
`
`

`

`3 R\ R6
`
`~ R9
`
`~ R10 19E¥~, R7
`
`~ R8 79~, R5 79#(, R1 79
`
`R2 79Ef=l~St, R 3 :;f§~79~;
`
`N~N
`\AAN/
`I
`
`3 R\ R6
`
`~ R9
`
`~ R10 19E¥~, R7
`
`0
`~ R8 ,79~, R 5 79#(, R179~--C
`
`at, R2
`
`5
`
`5f□ R3 :;f§~[rl]St19~o
`1=t*btS)jfil~:W1itmB{]~Jnff7JA ~' ?JTJ£imA (I) 1tirtm:
`1
`~ R2 ~ R3 ~§1EtliL±-fum§~~ m~ ~~~ ~~~ 11~~~ r£~~ -~~ ~
`
`R
`
`1~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 ~ 1~;l%~~ C1.3 t£;l%~~ C1.3 ;lJc~~~ C1.3
`
`~1~;l%~~~ C2.4 '.i:ffl~~ C2.4 tR:~~ C3.s lf;l%~~ 3-8 5G*lf~~ C6-10 :lY~~ 5-8
`
`-(CRasRbs)n4C(O)NRa9Rb9• ?JrJ£B{]~~~ C1.3 ;lJc~~ C1.3 m1~;lJc~~ C1.3 ~1~;lJc~~
`
`C1.3 t£;l%~~ C1.3 ;lJc~~~ C1.3 ~ 1~;l%~~~ C2.4 '.i:ffl~~ C2.4 tR:~~ C3-6 ;Ef ;lJc~~
`
`3-6 5G*lf~~ C6-10 :lY~~ 5-8 5G*:7Y~, 1fmB{Jfil~:Wii~~ ~ ~~~ 11~~~
`r£~~ -~~ ~1~~~ -NS(O)Ra1Rb1~ C1.3 ;lJc~~ C1.3 m1~;lJc~~ C1.3 ~1~;lJc~~
`
`15
`
`C1.3 t£;l%~~ C1.3 ;lJc~~~ C1.3 ~1~;l%~~~ C2.4 '.i:ffl~~ C2.4 tR:~~ C3-6 ;Ef;lJc~~
`
`3-6 5G*lf~~ C6-I0 :lY~~ 5-8 5G*:lY~~s{J~~~$~llR1~~?JrllR1~:
`~ R2~R3~§1EtliL±-fum§~~ m~ ~~~ ~~~ C1.3;lJc~~ C1.3
`1Jtm±-fu, R1
`
`m1~;l%~~ C1.3 ~1~;l%~~ C2.4 tR:~~ C3.s ;Ef;lJc~~ 3-8 5G*lf~~ 5-8 JG*:lY~~
`
`-NS(O)Ra1Rb1
`
`~
`
`-(CH2)n1S(O)NRa2Rb2 ~
`
`-P(O)Ra3Rb3 ~
`
`-NRasS(O)NRa4Rb4 ~
`
`20
`
`-(CH2)n1O(CH2)n2Ras~ -(CH2)n1C(O)NRa6Rb6~ -(CH2)n1P(O)Ra3Rb3~
`
`Rb7
`I
`-(CH2) 03S(O)
`II
`NR
`,=,-1';
`a7 .8-)<.
`
`-(CRasRbs)n4C(O)NRa9Rb9• ?JrJ£B{]~~~ C1.3 ;lJc~~ C1.3 m1~;lJc~~ C1.3 ~1~;lJc~
`
`~ C2.4tR:~, 1fmB{Jfil~:Wii~~~ -NS(O)Ra1Rb1~ C1.3;l}G~~ C3-6:Ef;l%~~B{]
`
`~~ ~$~ llR 1~~,rJrllR 1~:
`fil~iv1Jtm±-fu, R1~ R2 ~ R3 ~§1EtliL±-fum§~~ m~ ~~~ ~~~ C1.3 ;lJc
`
`4
`
`Conjupro EX1006
`Page 7 of 373
`
`

`

`~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C2.4 tR:~~ C3.s 1TT:Ef ;l%~~ C3.s ~J;Ef ;lJc~~ 13"
`~ 1-3 ~ * JJR -=f s,g 3-8 JG ~I* lf ~ ~ 5-8 JG* 7f ~ ~
`
`-NS(O)Ra1Rb1 ~
`
`-(CH2)n1S(O)NRa2Rb2 ~ -P(O)Ra3Rb3 ~ -NRasS(O)NRa4Rb4 ~ -(CH2)n1O(CH2)n2Ras ~
`
`5
`
`-(CRasRbs)n4C(O)NRa9Rb9• ?!rJ£B{]~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~
`
`~ C2.4tR:~, 1fmBtJtt:~iviiBI~~ -NS(O)Ra1Rb1~ C1.3;l}G~~ C3-6:Ef;l%~~B{]
`~~ ~$~ llR 1~~?frllR 1~ o
`
`a* bt S)j * ~ iv1Jtm s,g ~ Mff 1J A~ , ,rJrJ£imA co 1tirtm =
`R1~ R2 ~ R3 ~§1EtliL±-fum§~~ m~ Bf~~ ~~~ 11~~~ r£~~ -~~ ~
`1~~~ C1-6 ;lJc~~ C1-6 m1~;l%~~ C1-6 Bf 1~;l%~~ C1-6 t£;l%~~ C1-6 ;lJc~~~ C1-6
`BI1~;l%~~~ C2-6 '.J:m~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 JG*lf~~ C6-10 Yi~~ 5-10
`
`-
`};t_,---1-d-""i=r
`JG~:n~~ -NS(O)Ra1Rb1 ~ -(CH2)n1S(O)NRa2Rb2~ -P(O) Ra3Rb3~ -NRasS(O)NRa4Rb4,
`?!rJ£B{]~~~ C1-6 ;lJc~~ C1-6 m1~;l%~~ C1-6 Bf 1~;l%~~ C1-6 t£;l%~~ C1-6 ;lJc~~~
`C1-6 Bf 1~;l%~~~ C2-6 '.J:m~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 JG*lf~~ C6-10 Yi~~
`5-10 JG*Yi~, 1fms{JJ1t~iviiBI~~ ~~~ 11~~~ r£~~ It~~ ~1~~~
`
`-NS(O)Ra1Rb1~ C1-6 ;lJc~~ C1-6 m1~;lJc~~ C1-6 Bf1~;lJc~~ C1-6 t£;l%~~ C1-6 ;l%~
`~~ C1-6 Bf 1~;l%~~~ C2-6 '.ftm~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 JG*lf~~ C6-10 Yi
`
`a*btS)jJ1t~iv1Jtms{]~Mff1JA ~, ,rJrJ£imA co 1tirtm=
`R1~ R2 ~ R3 ~§1EtliL±-fum§~~ m~ Bf~~ ~~~ 11~~~ r£~~ -~~ ~
`1~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C1.3 t£;l%~~ C1.3 ;lJc~~~ C1.3
`Bf 1~;l%~~~ C2.4 '.J:m~~ C2.4 tR:~~ C3-6 ;Ef;lJc~~ 3-6 JG*lf~~ C6-10 Yi~~ 5-8
`
`-
`};t_,---1-d-"" i=r
`JG~:n~~ -NS(O)Ra1Rb1 ~ -(CH2)n1S(O)NRa2Rb2~ -P(O) Ra3Rb3~ -NRasS(O)NRa4Rb4,
`?!rJ£B{]~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C1.3 t£;l%~~ C1.3 ;lJc~~~
`C1.3 Bf 1~;l%~~~ C2.4 '.ftm~~ C2.4 tR:~~ C3-6 ;Ef;lJc~~ 3-6 JG*lf~~ C6-10 Yi~
`5¥□ 5-8 JG*Yi~, 1fmB{JJ1t~iviiBI~~ ~~~ 11~~~ r£~~ It~~ ~1~~~ C1.3
`;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C1.3 t£;l%~~ C1.3 ;lJc~~~ C1.3 Bf 1~;l%~~~
`C2.4 '.ftm~~ C2.4 tR:~~ C3-6 ;Ef;lJc~~ 3-6 JG*lf~~ C6-10 Yi~~ 5-8 JG*Yi~~
`
`10
`
`15
`
`20
`
`25
`
`5
`
`Conjupro EX1006
`Page 8 of 373
`
`

`

`5
`
`10
`
`R
`
`s{] ~~ ~$~ llR 1~~?JrllR 1~:
`1 ~ R
`2 ~ R
`3 ~ § Mu1JtMJtmiC m~ Bf~~ ~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~
`C1.3 BJ 1~ ;lJc ~ ~
`-P(O) Ra3Rb3 ~
`-NS(O)Ra1Rb1 ~
`-(CH2)n1S(O)NRa2Rb2 ~
`-NRasS(O)NRa4Rb4, ?JrJ£B{]~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~, 1fm
`s{JJ1t~:WiiBI~~ -NS(O)Ra1Rb1~ C1.3;lJc~~s{J~~~$~llR1~~?JrllR1~o
`
`a* bt S}j * ~ iv1Jtm s{] ~ Mff 1J A~ , ,rJrJ£imA co 1tirtm =
`
`Rbs~ Ra9 ~ Rb9 ~ § 1Etl_11J-fum § ~~ m~ BJ~~ ~~~ C1.3 ;lJc~~ C1.3 m{~;lJc~~
`c1.3 BI1~;tJc~~ c3.dJfEf;lJc~~ c3-6~tlf:lJc~~ *~ 1-3 ~m§ N~ o ~ s *JJR-1-
`s{] 3-8 5G*lf~~c6-107Y~~*~ 1-3 ~m§ N~o ~ s *JJR-=fs{] 5-6 5G*7Y~,
`?JrJ£B{]~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C3-611flf;l%~~ C3-6 ~J;Ef
`;tJc~~ *~ 1-3 ~m§ N~ o ~ s *JJR-=fs{] 3-8 5G*lf~~ c6-107Y~~*~ 1-3
`m§ N~ 0 ~ S ~*JJR-=fs{] 5-6 JG*:lY~, 1fm±-fuJ1t~:WiiBI~~ C1.3;l}G~~B{]
`~~ ~$~ llR 1~~?JrllR 1~:
`
`Rb7~ Ras~ Rbs~ Ra9~Rb9~§1EeiLf-fum§~~ m~ Bf~~ Ef=I~~ lfpg~~ 0~
`0, tjJ:l<l><l, {f½j;Jtll, ill zfilS(Jjj){J(fto
`
`0
`
`1=t*btS)jJ1t~:W{itmB{]~Jn!i7JA ~, ?JTJ£imA (I) 1tirtm:
`
`Ra1 lD Rb1 ~ Ra2 lD Rb2 ~ Ra3 lD Rb3 ~ Ra4 lD J¼i4 ~ Ra6 lD l¼i6 ~ Ras lD !¼is~
`
`20
`
`Ra9l0 Rb9)j-:1JiJ£5;f§~~B{JJJR-=f'fJ!1f%)J¼ C3.slf;lJc~~ 3-6 JG*lf~~ C6-10 :lY~~
`
`1Jtm±-fu, Ra1 l□ Rb1 ~ Ra2 l□ Rb2 ~ Ra3 l□ J¼i3 ~ Ra4 l□ Rb4 ~ Ra6 l□ l¼i6 ~ Ras
`
`l□ Rbs ~ Ra9 l□ Rb9 '5tJJiJ£5;f§~~ s{]JJR-=f'fJ!tf%)J¼ C3-6 ;Ef;lJc~~*~ 1-3 ~*JJR-=f B{]
`
`3-6 JG*lf~o
`
`Ra1 ~ Rb1 ~ Ra2~ Rb2~ Ra3~ Rb3~ Ra4 ~ Rb4 ~ § 1EtliLf-fum §~~ m~ BJ~~
`~~~ 11~~~ f£~~ It~~ C1-6 ;lJc~~ C1-6 m1~;l%~~ C1-6 Bf 1~;l%~~ C1-6 r£;l%~~
`C1-6 ;l%~~~ C1-6 Bf 1~;l%~~~ C2-6 '.ftm~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 5G*lf~~
`
`6
`
`Conjupro EX1006
`Page 9 of 373
`
`

`

`RM '5tJJiJ£5;f§~~B{]»R-1-'fJ!tf%)J¼ C3.s lf;l%~~ 3-8 5G*lf~~ C6-10 7'J~~ 5-10 5G
`*7'J~, ?fr;£ C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 7'J~~ 5-10 5G*7'J~, 1fmBtilt
`~:Wii~~ ~ ~~~ 11~~~ f£~~ It~~ ~1~~~ C1-6 ;lJc~~ C1-6 m1~;l%~~ C1-6
`5 ~ 1~;l%~~ C1-6 r£;l%~~ C1-6 ;lJc~~~ C1-6 ~ 1~;l%~~~ C2-6 '.i:ffl~~ C2-6 tR:~~ C3.s
`;Ef;l%~~3-8 5G*lf~~C6-107Y~~ 5-10 5G*7'J~~ s,g~~~$~1lR1~~?frllR1~o
`
`a* bt S)j * ~ iv1Jtm s,g ~ Mff 1J A~ , ,rJrJ£imA co 1tirtm =
`
`Ra1 ~ Rb1 ~ Ra2~ Rb2~ Ra3~ Rb3~ Ra4 ~ Rb4 ~ § 1Etlid-fum §~~ m~ ~~ ~
`~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 ~1~;l%~;
`Ra1 ~ Rb1 ~ Ra2~ Rb2~ Ra3~ Rb3~ Ra4 ~ Rb4 ~ § 1Etlid-&1Jtm~~ m~ ~~ ~
`
`Ef=[~;
`~~, Ra1 5f0 Rb1 ~ Ra2 5f0 Rb2~ Ra3 5f0 Rb3 ~ Ra4 5f0 Rb4 ')j-JJiJ £5 ;f§~~ B{] »R-1-'fJ!tf
`
`1Jtm Ra2 5¥□ Rb2~ Ra3 5¥□ Rb3 ~ § 1Etlid-ti1'5tJJiJ£5 ;f§~~ s,g »R-1-'fJ!tf% p)G C3.g ;Ef ;lJc
`
`10
`
`15
`
`20
`
`25
`
`~~ 13"~ 1-3 ~*»R-1-B{] 3-6 5G*lf~o
`a*btS)jJ1t~:W1xms{]~Mff1JA ~, ,rJrJ£imA co 1tirtm=
`R\ Rs~ R6 ~ § 1EtliL±-fum § ~~ m~ ~~ ~ ~~~ C1.3 ;lJc~~ C1.3 m1~;lJc~~
`C1.3 ~1~;l%~;
`R\ Rs~ R6 ~§1EeiL±-fu1Jtm#\i, Ef:1~ 0
`1=t*btS)jJ1t~:W1itmB{]~Jn!i7JA ~' ?!rJ£imA (I) 1tirtm:
`){th ----'---. _j.J.h ~!±: 6 ~ ,8 ~ ~ C
`,~,-,_. i=r C
`R7 R8 R9 ,=,I'; RlO /,z 6
`ttt=l<1~Jl.;:L':,,1&t=J~~ JTl.~ 125-JYA~
`1-3/'Jt~~
`~
`~
`C1.3 ~1~;l%~;
`R7 ~ R8 ~ R 9 ~R10 1JtmEf=l~o
`1=t*btS)j s,g55~~Mff7JA ~, ,rJrJ£imA co 1tirtm:
`2 ~ R
`3 ~§1EtliL±-fum§~~ m~ ~~~ ~~~ 11~~~ f£~~ -~~ ~
`R
`~ R
`1~~~ C1-6 ;lJc~~ C1-6 m1~;l%~~ C1-6 ~ 1~;l%~~ C1-6 r£;l%~~ C1-6 ;lJc~~~ C1-6
`~1~;l%~~~ C2-6 '.i:ffl~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 7'J~~ 5-10
`
`9-)<.
`
`,81+1,~,-,_. i=r
`l-3JTl. 1..,;,fi;~~
`
`1
`
`7
`
`Conjupro EX1006
`Page 10 of 373
`
`

`

`-( CH2)n1 0( CH2)n2Ras ~ -( CH2)n1 C( 0 )NRa6Rb6 ~ -( CH2)n1 P( 0 )Ra3Rb3 ~
`
`Rb7
`I
`-(CH2) 03S(O)
`II
`NRa7 ,
`
`?!rJ£B{]~~~ C1-6 ;lJc~~ C1-6 :JnJt;;lJc~~ C1-6 Bf 1~;l%~~ C1-6 r£;l%~~ C1-6 ;lJc-~~
`C1-6 Bf 1~;l%-~~ C2-6 '.ftm~~ C2-6 tR:~~ C3.s lf;l%~~ 3-8 5G*lf~~ C6-10 :lY~~
`5-10 5G*7'J~, 1fms{Jjji~:Wii BI~~ ~~~ 11~~~ r£~~ •~~ •1~~~
`-NS(O)Ra1Rb1 ~ C1-6 ;lJc~~ C1-6 m1~;lJc~~ C1-6 BJ 1~;lJc~~ C1-6 r£;l%~~ C1-6 ;lJc.
`~~ C1-6 Bf 1~;l%-~~ C2-6 '.ftm~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 7Y
`~~ 5-10 5G*7'J~~s,g~~~$~llR1~~?frllR1~:
`a* bt S)j * ~ :W1xm s,g 55 ~ ~ Mff 1J A~ , ,rJrJ£imA co 1tirtm =
`R 1 l□ R2 £5;f§~~B{]JJR-1-'fJ!tf%)J¼ C3.10 ;Ef;lJc~~ 3-10 5G*lf~~ C6-12 :lY~~
`
`Mtll.±-&m§~~ m~ BI~~ ~~~ 11~~~ r£~~ •~~ c1-6:lJc~~ c1-6m1~:lJc~~
`C1-6 Bf 1~;l%~~ C1-6 r£;l%~~ C1-6 ;lJc-~~ C1-6 Bf 1~;l%-~~ C2-6 '.ftm~~ C2-6 tR:~~
`C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 7'J~~ 5-10 5G*7'J~, ?!rJ£B{]~~ C1-6 ;lJc~~
`C1-6 m1~;l%~~ C1-6 Bf 1~;l%~~ C1-6 r£;l%~~ C1-6 ;lJc-~~ C1-6 Bf 1~;l%-~~ C2-6
`m~~ C2-6 tR:~~ C3.g ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 :lY~~ 5-10 JG*:lY~, 1fm
`s,gjji~:WiiBI~~ ~~~ 11~~~ f£~~ -~~ •1~~~ -NS(O)Ra1Rb1~ C1-6;l%~~
`C1-6 m1~;l%~~ C1-6 Bf 1~;l%~~ C1-6 r£;l%~~ C1-6 ;lJc-~~ C1-6 Bf 1~;l%-~~ C2-6
`
`~ ~$~ llR 1~~?frllR 1~ o
`1=t*btS)jjji~:WfitmB{J55~~Mff7JA ~, ?!rJ£imA (I) 1tirtm:
`Ra1 l□ Rb1 ~ Ra2 lD Rb2 ~ Ra3 l□ Rb3 ~ Ra4 l□ Rb4 ')j-JJiJ £5 ;f§ ~~ s,g JJR-1-'fJ!tf % p)G
`C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 :lY~~ 5-10 JG*:lY~, ?fr;£ C3.s ;Ef;lJc~~ 3-8
`5G*lf~~ c6-10 :lY~~ 5-10 5G*7'J~, 1fms{Jjji~:WiiBI~~ ~~~ 11~~~ r£
`~~ It~~ -1~~~ C1-6 ;lJc~~ C1-6 m1~;l%~~ C1-6 Bf 1~;l%~~ C1-6 r£;l%~~ C1-6
`;lJc-~~ C1-6 Bf 1~;l%-~~ C2-6 '.ftm~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10
`7'J~~ 5-10 5G*7'J~~s,g~~~$~1lR1~~?frllR1~o
`
`8
`
`5
`
`15
`
`25
`
`Conjupro EX1006
`Page 11 of 373
`
`

`

`a* bt S}j * ~ :W 1Jtm s{] 55 ~ ~ Mff 1J A ~ , ,rJrJ£iffi A c o 1i if tm =
`~,~~~~§¾~~m§~,m, ~•,u~,m~,~~,«~,-
`1~~, C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~ 1~;l%~, C1-6 ~;lJc~, C1-6 ;lJc-~, C1-6
`
`~1~;l%-~, C2-6'.i:ffl~, C2-6~~' C3.slf;l%~, 3-8 51:Jj~;Ef~, C6-107Y~~ 5-10
`
`5
`
`5G*7'J~, ?JrJ£B{]U~, C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~1~;l%~, C1-6 ~;lJc~,
`
`C1-6 ;l%-~, C1-6 ~1~;l%-~, C2-6 '.i:ffl~, C2-6 ~~' C3.s ;Ef;lJc~, 3-8 5G*lf~,
`C6-10 7'J~~ 5-10 5G*7'J~, 1fmB{Jfil~:Wii~., U~, 11~~, ~~, «~,
`-1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~ 1~;l%~, C1-6 ~;lJc~, C1-6 ;lJc-~, C1-6
`
`~1~;l%-~, C2-6 '.i:ffl~, C2-6 ~~' C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :lY~~ 5-10
`
`10
`
`5G*7'J~~s{J~~~$~llR1~~?JrllR1~o
`
`1=t*btS)jfil~:W1JtmB{J55~~Mff7JA ~, ?JTJ£imA (I) 1tirtm:
`R7 R8 R9 ,=,I'; RlO ,;,z 6 ){th ---'--- _j.J.h ~!±: 6 ~ ~ ~ ~ ~ i=r
`1m i=r
`'/:7-. i=r
`J;I½ i=r
`ttt=l<1~Jl.;:L':.,1&t=J~, )Tl., 125-JYA, ~~, 11~~, ;.I~, W,~,
`-1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~ 1~;l%~, C1-6 ~;lJc~, C1-6 ;lJc-~, C1-6
`
`,
`
`,
`
`9-)<.
`
`~1~;l%-~, C2-6 '.i:ffl~, C2-6 ~~' C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :lY~~ 5-10
`5G*7'J~, 1fmB{Jfil~:Wii~., U~, 11~~, ~~, «~, -1~~, C1-6;l%~,
`C1-6 m1~;l%~, C1-6 ~ 1~;l%~, C1-6 ~;lJc~, C1-6 ;lJc-~, C1-6 ~ 1~;l%-~, C2-6
`
`~ ~$~ llR 1~~,rJrllR 1~ o
`
`1=t*btS)jfil~:W1JtmB{J55~~Mff7JA ~, ?JTJ£imA (I) 1tirtm:
`3
`2 ~ R
`~§1Etl~±-fum§~, m, ~., -~' 11~~' ~~' -~' -
`1~~' C1.3 ;lJc~, C1.3 m1~;l%~, C1.3 ~ 1~;l%~, C1.3 ~;lJc~, C1.3 ;lJc-~, C1.3
`
`1,
`
`R
`
` R
`
`15
`
`20
`
`~1~;l%-~, C2.4 '.i:ffl~, C2.4 ~~' C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :lY~, 5-8
`
`-(CH2)n1O(CH2)n2Ras, -(CH2)n1C(O)NRa6Rb6, -(CH2)n1P(O)Ra3Rb3,
`
`Rb7
`I
`-(CH2)n3S(O)
`II
`NRa7,
`
`25
`
`?JrJ£B{]U~, C1.3 ;lJc~, C1.3 m1~;l%~, C1.3 ~1~;l%~, C1.3 ~;lJc~, C1.3 ;lJc-~,
`
`C1.3 ~1~;l%-~, C2.4 '.i:ffl~, C2.4 ~~' C3-6 ;Ef;lJc~, 3-6 5G*lf~, C6-10 :lY~
`~ 5-8 5G*7'J~, 1fms{Jfil~:Wii~., U~, 11~~, ~~, «~, -1~~,
`-NS(O)Ra1Rb1, C1.3 ;lJc~, C1.3 m1~;lJc~, C1.3 ~1~;lJc~, C1.3 ~;lJc~, C1.3 ;lJc-
`
`9
`
`Conjupro EX1006
`Page 12 of 373
`
`

`

`~~ C1.3 Bf 1~;l%~~~ C2.4 '.i:m~~ C2.4 tR:~~ C3-6 ;Ef;l%~~ 3-6 5G*lf~~ C6-10
`
`:lY~~ 5-8 5G*:lY~~s{J~~~$~llR1~~?JrllR1~:
`R 1 ~ R2 ~ R3 ~ § Mu1JtMJtmiC m~ Bf~~ ~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~
`C1.3 BJ {~;lJc~~ C2.4 tR:~~ C3.s ;Ef;lJc~~ 3-8 JG*lf~~ 5-8 JG*:lY~~ -NS(O)Ra1Rb1 ~
`-(CH2)n1S(O)NRa2Rb2~ -P(O) Ra3Rb3~ -NRasS(O)NRa4Rb4~ -(CH2)n1O(CH2)n2Ras~
`
`5
`
`Rb7
`I
`-(CH2) 03S(O)
`II
`-(CH2)n1C(O)NRa6Rb6~ -(CH2)n1P(O)Ra3Rb3~
`NRa7 , ?JrJ£B{]~~~ C1.3 ;lJc
`~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C2.4 tR:~, 1fmBtJtt:~iviiBI~ ~ -NS(O)Ra1Rb1 ~
`C1.3 ;lJc~~ C3-6 ;Ef;lJc~~ s{J~~~$~llR1~~?JrllR1~:
`R 1 ~ R2 ~ R3 ~ § 1Etl_11J-t11:J1t~iv1xmic m~ BI~~ ~~~ c1.3 ;tJc~~ c1.3
`10 m1~;l%~~ C1.3 Bf 1~;l%~~ C2.4 tR:~~ C3.s 11flf;l%~~ C3.s ~J;Ef;lJc~~ 13"~ 1-3 ~
`
`*JJR-=f B{] 3-8 JG~J*lf~~ 5-8 JG*:lY~~ -NS(O)Ra1Rb1 ~ -(CH2)n1S(O)NRa2Rb2~
`
`-P(O) Ra3Rb3~ -NRasS(O)NRa4Rb4~ -(CH2)n1O(CH2)n2Ras~ -(CH2)n1C(O)NRa6Rb6~
`
`Rb7
`I
`-(CH2) 03S(O)
`II
`-(CH2)n1P(O)Ra3Rb3~
`NRa7 , ?JrJ£B{]~~~ C1.3 ;lJc~~ C1.3 m{~;lJc~~ C1.3
`BI1~;l%~~ C2.4tR:~, 1fmB{J:Jtt~iviiBI~~ -NS(O)Ra1Rb1~ C1.3;lJc~~ C3_6:Ef;l%
`~~s{J~~~$~1lR1~~?JrllR1~o
`
`a* bt S)j * ~ iv1Jtm s{] 55 ~ ~ Mff 1J A~ , ,rJrJ£imA co 1tirtm =
`
`R 1 5¥□ R21=5;t§~~s{]JJR-=f'fJttf%JJ)G1'i~ 1-4 ~*JJR-=f s{] 3-10 5Gtflff*lf~:
`R 1 5¥□ R2 £5;f§~~B{]JJR-=f'fJ!tt1Jtm%JJ)G1,i~ 1-4 ~ N JJR-=fs{] 9 5Glflff*lf~o
`1=t*btS)j:Jtt~ivfitmB{J55~~Mff7JA ~, ?JTJ£imA (I) 1tirtm:
`
`1Etl_11J-fum § ~~ m~ Bf~~ ~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C3-6
`11flf;l%~~ C3-6 ~J;Ef;lJc~~ 13"~ 1-3 ~*JJR-=f B{] 3-8 5G*lf~~ C6-10 :lY~~ 13"~
`1-3 ~*JJR-=f B{] 5-6 JG*:lJ~, ?JrJ£B{]~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~
`;lJc~~ C3-611flf;l%~~ C3-6 ~J;Ef;lJc~~ 13"~ 1-3 ~*JJR-=f B{] 3-8 5G*lf~~ C6-10
`:lJ~~ *~ 1-3 ~*JJR-=f B{] 5-6 JG*:lJ~, 1fm±-fu:Jtt~iviiBI~, C1.3 ;lJc~?JrllR
`1~;
`
`15
`
`25
`
`Conjupro EX1006
`Page 13 of 373
`
`

`

`Jof; Pi c!;li, 0 , 0 , it l><J , {-f i,J;
`JHJ:ill {lti,J; 'A, Jn, IE#:, rr c!;li,
`±1'1 , * - iv ii• llR 1~ o
`a* bt S)j * - :W1xm s{] 55 - ~ Mff 1J A~ , ,rJrJ£imA co 1tirtm =
`Ra1 5f0 Rb1, Ra2 5f0 Rb2, Ra3 5f0 Rb3, Ra4 5f0 Rb4 JtJJiJ £5 ;f§ ~~ B{] JJR-1-'fJ!tf % P¼ C3.s
`;Ef;lJc~, 3-6 5G*lf~, C6-10 :lY~~ 5-8 JG*:lJ~;
`1Jtm Ra2 5¥□ Rb2, Ra3 5¥□ Rb3 ~ § Mu1J-fu'5tJJiJ£5 ;f§~~ s{] JJR-1-'fJ!tf% p)G C3.g ;Ef ;lJc
`~, 13"~ 1-3 ~*JJR-1-s{] 3-6 5G*lf~o
`1=t*btS)jjji-:WfitmB{]55-~Jnff7JA ~, ?JTJ£imA (I) 1tirtm:
`R\ Rs~ R6 ~ § Mu1J-fum § ~' m, Bf~, ~~' C1.3 ;lJc~, C1.3 m1~;l%~,
`C1.3 Bf 1~;l%~:
`R\ Rs~ R6 ~§1Eeid-fu1Jtm#(, Ef:1~ 0
`1=t*btS)jjji-:WfitmB{]55-~Jnff7JA ~, ?JTJ£imA (I) 1tirtm:
`,~,-,_. i=r C
`R7 R8 R9 ,=,I'; RlO /,z 6 ){th ----'---. _j.J.h ~!±: 6 ~ ,8 ~ ~ C
`,81+1,~,-,_. i=r
`ttt=l<1~Jl.;:L':,,1&t=J~, JTl., 125-JYA,
`1-3/'Jt~,
`l-3JTl. 1..,;,fi;~,
`C1.3 Bf 1~;l%~:
`7
`
`8
`
`' R
`
`10 ~ § 1Etlid-&1JtmE¥~o 1=t*btS)jjji-:WfitmB{]~Jn!i7JA ~'
`9 ~ R
`' R
`,rJrJ£B{]ifilA CO 1tirtmjji-:W~DimA CI-I) ?Jr?F:
`
`5
`
`10
`
`15
`
`R
`
`,
`
`,
`
`9-)<.
`
`(I-1)
`*btS)j~§~a~m*-#iffiACrr)m?F~~if~,~~~#~~~~~
`"¥=.t. PJtlxJiR:
`
`11
`
`Conjupro EX1006
`Page 14 of 373
`
`

`

`(ll)
`
`5
`
`C6-14 :lY~~ 5-14 JG*:lY~, ?fr;£ C3.12 ;Ef;lJc~~ 3-12 5G*lf~~ C6-14 :lY~~ 5-14
`5G*:7J~, 1fms{Jjji~:Wii~~~ ~~~ 11~~~ r£~~ •~~ •1~~~ c1-6:lJc~~
`C1-6 m1~;l%~~ C1-6 ~ 1~;l%~~ C1-6 t£;l%~~ C1-6 ;lJc-~~ C1-6 ~ 1~;l%-~~ C2-6
`
`10
`
`15
`
`R1~ R2
`m§~~ m~ ~~~ ~~~ 11~~~ r£~~ •~~ •1~~~
`~ R3 ~ R11
`C1-6 ;lJc~~ C1-6 m1~;l%~~ C1-6 ~1~;l%~~ C1-6 t£;l%~~ C1-6 ;lJc-~~ C1-6 ~1~;l%
`-~~ C2-6 '.i:ffl~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 :lY~~ 5-10 JG*:lY
`~~ -NS(O)Ra1Rb1 ~ -(CH2)n1S(O)NRa2Rb2~ -P(O) Ra3Rb3 ~-NRasS(O)NRa4Rb4, ?fr
`J£s{]~~~ C1-6 ;lJc~~ C1-6 m1~;l%~~ C1-6 ~ 1~;l%~~ C1-6 t£;l%~~ C1-6 ;lJc-~~
`C1-6 ~1~;l%-~~ C2-6 '.i:ffl~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 :lY~~
`5-10 5G*:7J~, 1fms{Jjji~:Wii~~~ ~~~ 11~~~ r£~~ •~~ •1~~~
`-NS(O)Ra1Rb1~ C1-6 ;lJc~~ C1-6 m1~;lJc~~ C1-6 ~1~;lJc~~ C1-6 t£;lJc~~ C1-6 ;lJc.
`~~ C1-6 ~1~;l%-~~ C2-6 '.i:ffl~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 7Y
`
`Ra1~ Rb1~ Ra2~ Rb2~ Ra3~ Rb3~ Ra4~ Rb4~§Mu1J-fum§~~ m~ ~~~
`20 ~~~ 11~~~ r£~~ It~~ C1-6 ;lJc~~ C1-6 m1~;l%~~ C1-6 ~ 1~;l%~~ C1-6 t£;l%~~
`C1-6 ;l%-~~ C1-6 ~1~;l%-~~ C2-6 '.i:ffl~~ C2-6 tR:~~ C3.s ;Ef;lJc~~ 3-8 5G*lf~~
`
`---1-d-"" i=r ,=,I';
`j;t, ---1-d-"" i=r
`-
`C6-10 n~.8-)<. 5-10 7G~7'Y~;
`
`~~, Ra15f0 Rb1~ Ra25f0 Rb2~ Ra37f0 Rb3~ Ra47f0 Rb4)j-JJiJ£5;f§~~B{JJJR-1-'fJ!1f
`%}J)G C3.s ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 :lY~~ 5-10 JG*:lY~, ?fr;£ C3.s ;Ef;lJc~~
`
`12
`
`Conjupro EX1006
`Page 15 of 373
`
`

`

`3-8 51:Jr(Ef~, c6-10 :lY~~ 5-10 5G*7'J~, 1fms{]J1t-:Wii~•, •~, 11~~,
`f£~, It~, -1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~ 1~;lJc~, C1-6 r£;l%~, C1-6
`;lJc-~, C1-6 ~ 1~;lJc-~, C2-6 '.J:m~, C2-6 tR:~, C3.s lf;l%~, 3-8 5G*lf~, C6-10
`7'J~~ 5-10 5G*7'J~~s{]-~~$~1lR1~~?JrllR1~:
`~,~~~~§¾~~m§~,m, ~•,u~,m~,r£~,1t~,-
`1~~, C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~ 1~;lJc~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6
`~1~;lJc-~, C2-6 '.J:m~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :lY~ 5-10
`5G*7'J~, ?JrJ£B{]U~, C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~1~;l%~, C1-6 r£;l%~,
`C1-6 ;l%-~, C1-6 ~1~;lJc-~, C2-6 '.J:m~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~,
`C6-10 7'J~~ 5-10 5G*7'J~, 1fmB{]Jlt-:Wii~., U~, 11~~, r£~, It~,
`-1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~ 1~;lJc~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6
`~1~;lJc-~, C2-6 '.J:m~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :lY~~ 5-10
`5G*7'J~~~-~~$~llR~~mllR~:
`R7, R8, R9 ~ R10 ~§Ml~f-fum§~, m, ~., -~' 11~~' f£~, -~'
`-1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 ~ 1~;lJc~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6
`~1~;lJc-~, C2-6 '.J:m~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :lY~ 5-10
`5G*7'J~, 1fmB{]Jlt-:Wii~., U~, 11~~, r£~, It~, -1~~, C1-6;l%~,
`C1-6 m1~;l%~, C1-6 ~ 1~;lJc~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6 ~ 1~;lJc-~, C2-6
`
`5
`
`10
`
`15
`
`20 ~~$~1lR1~~?JrllR1~:
`nl 7'J 0-5 B{]~~o
`a*~~Jlt-:W~m~~~~~~. mJ£~~crr)~~~=
`R1 l□ R2
`, R1 l□ R11 7tJJiJ--'=5;f§~~ s{]JJR-1-'fJttf%)J¼ c3-8 lf:lJc~, 3-8 5G*lf~,
`C6-10 7'J~~ 5-10 JG*:lY~, ,r)rj£ C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :lY~~ 5-10
`5G*7'J~, 1fmB{]Jlt-:Wii~., U~, 11~~, r£~, It~, -1~~, C1-6;l%~,
`C1-6 m1~;l%~, C1-6 ~ 1~;lJc~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6 ~ 1~;lJc-~, C2-6
`
`25
`
`~ ~$~ llR 1~~?JrllR 1~ o
`a*~~Jlt-:W~m~~~~~~. mJ£~~crr)~~~=
`
`13
`
`Conjupro EX1006
`Page 16 of 373
`
`

`

`R 1 l□ R2 ~ R1 l□ R11 JtJJU--'=5 ;f§~~ s,g JJR-1-'fJttt% p)G c3-6 lf :lJc~~ 3-1 o 5G*lf~~
`c6-10 :lY~~ 5-8 5G*7'J~, 1fms{]jji-:W*i~~ ~ c1.3 ;tJc~~ ~~~~1~~~ s,g
`-~ ~$~ llR 1~~?JrllR 1~:
`1xm±-&, R1 l□ R2 ~ R1 l□ R11 7tJJiJ--'=5;f§~~ s{]JJR-1-'fJttf%}J)G1'i~ 1-3 ~m § N ~
`5 o ~ s s,g 5-7 5G*lf~, 1fms{]jji-:Wii~1~~?JrllR1~o
`a*~~*-:W~m~~~~~~. m~~~crr)~~~=
`
`HN,"O
`
`'s' (~
`
`N~_ . . i
`H
`.,,-,
`
`~
`
`Q Q
`OQ 0~ o~H O t o
`1/ ~:~
`1
`x~
`_:;f, 1fms{]jji-:W*i~~~ c1.3
`Y-~
`;lJc~~ C1.3 m1~;l%~~ C3-6 ;Ef;lJc~~ ~~~~1~~~ s{]-~~$~}lR 1~~?JrllR 1~0
`a*~~*-:W~m~~~~~~. m~~~crr)~~~=
`R1 l□ R2 ~ R1 l□ R11 7tJJiJ--'=5;f§~~ s{]JJR-1-'fJttf%}J)G c3-6 lf:lJc~~ 3-8 5G*lf~~
`c6-10 :lY~~ 5-8 5G*7Y~, 1fms{]jji-:W*i~~ ~ ~~~ ~1~~~ s,g-~~$
`~ llR 1~~ ?Jr llR 1~:
`R1 l□ R2 ~ R1 l□ R 11 1Jtm7tJJiJ--'=5;f§~~ s{]JJR-1-'fJttf%}J)G1'i~ 1-3 ~m § N ~ o ~
`s s,g 5-7 5G*lf~, 1fms{]jji-:Wii~1~~?JrllR1~o
`a*~~*-:W~m~~~~~~. m~~~crr)~~~=
`
`15
`
`14
`
`Conjupro EX1006
`Page 17 of 373
`
`

`

`;lJc~~ C1-6 Bf 1~;l%~~ C1-6 r£;l%~~ C1-6 ;lJc-~~ C1-6 Bf 1~;l%-~~ C2-6 '.i:ffl~~ C2-6
`
`tR:~~ C3.s lf;lJc~~ 3-8 JG*lf~~ C6-10 :lJ~~ 5-10 JG*:lY~~ -NS(O)Ra1Rb1 ~
`
`-(CH2)n1S(O)NRa2Rb2~ -P(O) Ra3Rb3 ~-NRasS(O)NRa4Rb4, ?!rJ£B{]~~~ C1-6 ;lJc~~
`C1-6 m1~;l%~~ C1-6 Bf 1~;l%~~ C1-6 r£;l%~~ C1-6 ;lJc-~~ C1-6 Bf 1~;l%-~~ C2-6
`5 m~~ C2-6 tR:~~ C3.g ;Ef;lJc~~ 3-8 5G*lf~~ C6-10 :lJ~~ 5-10 JG*:lJ~, 1fm
`s{]J1t-:WiiBI~~ ~~~ 11~~~ f£~~ -~~ •1~~~ -NS(O)Ra1Rb1~ C1-6;l%~~
`C1-6 m1~;l%~~ C1-6 Bf 1~;l%~~ C1-6 r£;l%~~ C1-6 ;lJc-~~ C1-6 Bf 1~;l%-~~ C2-6
`
`10
`
`R 3 1itmiC m~ Bf~~ ~~~ 11~~~ f£~~ -~~ •1~~~ C1.3 ;lJc~~ C1.3
`m1~;l%~~ C1.3 Bf 1~;l%~~ C1.3 r£;l%~~ C1.3 ;lJc-~~ C1.3 Bf 1~;l%-~~ C2.4 m~~
`
`C2.4 tR:~~ C3-6 ;Ef;lJc~~ 3-6 JG*lf~~ C6-10 :lY~~ 5-8 JG*:lY~~ -NS(O)Ra1Rb1 ~
`
`-(CH2)n1S(O)NRa2Rb2~ -P(O) Ra3Rb3 ~-NRasS(O)NRa4Rb4, ?!rJ£B{]~~~ C1.3 ;lJc~~
`C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C1.3 r£;l%~~ C1.3 ;lJc-~~ C1.3 Bf 1~;l%-~~ C2.4
`'.i:m~~ C2.4 tR:~~ C3-6 ;Ef;lJc~~ 3-6 5G*lf~~ C6-10 :lY~~ 5-8 5G*:7Y~, 1fmB{]
`J1t-:WiiBf~ ~ ~~~ 11~~~ f£~~ -~~ -1~~~ -NS(O)Ra1Rb1 ~ C1.3 ;lJc~~
`C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C1.3 r£;l%~~ C1.3 ;lJc-~~ C1.3 Bf 1~;l%-~~ C2.4
`
`~ ~$~ llR 1~~?frllR 1~:
`R3 £1itmiC m~ Bf~~ ~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 BI1~;l%~~
`-NS(O)Ra1Rb1 ~ -(CH2)n1S(O)NRa2Rb2~ -P(O)Ra3Rb3 ~-NRasS(O)NRa4Rb4, ?!rJ£B{]~
`~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~, 1fmB{]J1t-:WiiBI~ ~ -NS(O)Ra1Rb1
`~ C1.3 ;lJc~~ s{]-~~$~1lR1~~?frllR1~o
`
`a*~~J1t-:W~m~~~~~~. mJ£~~crr)~~~=
`R l R2 R3 ,=,I'; Rll J--);'.~!±:~ ~ ~~ ~i=r
`~1+1--l=r
`,;114--l=r
`'/:7-,i=r
`1mi=r
`125-1 YA~ ~~~ 1-1~~~ ;.:r.~~ "~\~~ ~ \,~~
`IJL;~~~ JTl.~
`~
`~
`C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C1.3 r£;l%~~ C1.3 ;lJc-~~ C1.3 Bf 1~;l%
`
`9-)<.
`
`-~~ C2.4 '.i:ffl~~ C2.4 tR:~~ C3-6 ;Ef;lJc~~ 3-6 5G*lf~~ C6-10 :lY~~ 5-8 JG*:lY
`~~ -NS(O)Ra1Rb1 ~ -(CH2)n1S(O)NRa2Rb2~ -P(O) Ra3Rb3 ~-NRasS(O)NRa4Rb4, ?fr
`J£s,g~~~ C1.3 ;lJc~~ C1.3 m1~;l%~~ C1.3 Bf 1~;l%~~ C1.3 r£;l%~~ C1.3 ;lJc-~~
`C1.3 Bf 1~;l%-~~ C2.4 '.i:m~~ C2.4 tR:~~ C3-6 ;Ef;lJc~~ 3-6 5G*lf~~ C6-10 :lY~~
`15
`
`15
`
`20
`
`25
`
`30
`
`Conjupro EX1006
`Page 18 of 373
`
`

`

`5-8 JG*:lY~, 1fmB{]jji-:W*i~~ ,~~,,p~~,f£~, ft~,~i~~,-NS(O)Ra1Rb1,
`C1.3 ;lJc~, C1.3 m1~;l%~, C1.3 ~ 1~;lJc~, C1.3 t£;l%~, C1.3 ;lJc~~' C1.3 ~ 1~;l%
`~~' C2.4 '.);m~, C2.4 tR:~, C3-6 ;Ef;lJc~, 3-6 5G*lf~, C6-10 7'J~~ 5-8 JG*
`
`C1.3 ~ 1~ ;lJc ~ ,
`-P(O)Ra3Rb3 ~
`-NS(O)Ra1Rb1 ,
`-(CH2)n1S(O)NRa2Rb2 ,
`-NRasS(O)NRa4Rb4, fi)TJ£B{]~~' C1.3 ;lJc~, C1.3 m1~;l%~~ C1.3 ~1~;lJc~, 1fm
`s{]jji-:W*i~~' -NS(O)Ra1Rb1 ~ C1.3 ;lJc~~ s{]-~~$~llR1~~ji)TljR{~;
`
`IO
`
`a*~~*-:W~m~~~~~~. mJ£~~crr)~~~=
`1Jtm±-fu' Ra1' Rb 1' Ra2' Rb2' Ra3' Rb3' Ra4 ~ Rb4 ~ § Mu1J-fum § ~' m'
`~~, ~~' C1.3 ;lJc~, C1.3 m1~;l%~~ C1.3 ~1~;l%~;
`jji-:W1itm±-fu, Ra1' Rb1' Ra2, Rb2, Ra3, Rb3, Ra4 ~ Rb4 ~ § Mu1J-fum §
`~, m, ~~~E¥~;
`~~, Ra15f0 Rb1, Ra25f0 Rb2, Ra37f0 Rb3' Ra47f0 Rb4)j-JJiJ£5;f§~~B{JJJR-1-'fJ!1f
`
`a*~~*-:W~m~~~~~~. mJ£~~crr)~~~=
`1Jtm±-fu, Ra2 5¥□ Rb2, Ra3 5¥□ Rb3 '5tJJiJ£5;f§~~B{]JJR-1-'fJ!tf%}J)G C3.g ;Ef;lJc~~*
`
`~ 1-3 ~*JJR-1-s{] 3-6 5G*lf~o
`
`20
`
`a*~~*-:W~m~~~~~~. mJ£~~crr)~~~=
`1Jtm±-fu, R\ R 5 ~R6~§1EtliL±-fum§~, m, ~~' ~~' C1.3;l}G~, C1.3
`m1~;l%~~ C1.3 ~1~;l%~;
`jji-:W{Jtmf-fu, R\ R5 ~ R6 ~§1EeiLf-fum§#C~Ef=!~o
`
`a*~~*-:W~m~~~~~~. mJ£~~crr)~~~=
`, R9 ~ R10 ~§1EeiLf-fum§~, :m,, ~~' C1.3 ;lJc~, C1.3
`1Jtm±-fu, R7
`, R8
`25 m1~;l%~~ C1.3 ~1~;l%~;
`, R9 ~ R10 ~ § 1EtliLf-fum § Ef=!~o
`jji-:W{Jtmf-fu, R7
`, R8
`a*~~*-:W~m~~~~~~. mJ£~~~crr)~~~*-:W~~~
`(ll-1) fife~:
`
`16
`
`Conjupro EX1006
`Page 19 of 373
`
`

`

`*~~~§~a~m*-#~~cm)m~~~~~,~~~#~~~~~
`"¥= __t PJ ti xJiR =
`
`(ll-1)
`
`(III)
`
`5
`
`10
`
`~~.
`-~~ -~-~
`-~rr~
`rr~~
`rr ~ 6
`r'I' A )& t=l C3-12 r'l';,fi;~, 3-12 JG~µI'~, C6-14 77~.8-)<. 5-14 JG~:n~;
`R 12 m§ic m, BI~,~~, 11~~, r£~, tt~, ~1~~, c1-6:lJc~, c1-6
`m1~;l%~, C1-6 Bf 1~;l%~, C1-6 r£;l%~, C1-6 ;lJc~~' C1-6 Bf 1~;l%~~' C2-6 '.i:ffl~,
`C2-6 ~~, C3_s lf;l%~, 3-8 5fJj~lf~, C6-10 7'J~ 5-10 5G*7'J~, 1fmB{]:Jtt-iv
`ii BI~, ~~, 11~~, r£~, It~, ~1~~, C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 Bf
`1~;l%~, C1-6 r£;l%~, C1-6 ;lJc~~, C1-6 Bf 1~;l%~~, C2-6 '.i:m~, C2-6 ~~, C3_s
`;Ef;lJc~,3-8 5G*lf~,c6-107Y~~ 5-10 5G*7'J~~ s,g-~~$~llR1~~?JrllR1~:
`
`R3 m § iC m, Bf~, ~~, 11~~, f£~, It~, ~1~~, C1-6 ;l%~, C1-6
`15 m1~;l%~, C1-6 Bf 1~;l%~, C1-6 r£;l%~, C1-6 ;lJc~~' C1-6 Bf 1~;l%~~' C2-6 '.i:ffl~,
`
`C2-6 ~~' C3_s ;Ef;lJc~, 3-8 JG*lf~, C6-10 :lY~, 5-10 JG*:lY~, -NS(O)Ra1Rb1,
`-(CH2)n1S(O)NRa2Rb2, -P(O) Ra3Rb3 ~-NRasS(O)NRa4Rb4, ?JrJ£B{]~~' C1-6 ;lJc~,
`
`17
`
`Conjupro EX1006
`Page 20 of 373
`
`

`

`C1-6 :JnJt;;lJc~, C1-6 Bf 1~;l%~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6 Bf 1~;l%-~, C2-6
`m~, c2-6 tR:~, c3.s lf:lJc~, 3-8 5G*lf~, c6-10 :JJ~~ 5-10 5G*:JJ~, 1fm
`s{JJ1t~:WiiBI., -~ ' 11~~' f£~, -~ ' •1~~' -NS(O)Ra1Rb1, C1-6;l%~,
`C1-6 m1~;l%~, C1-6 Bf 1~;l%~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6 Bf 1~;l%-~, C2-6
`
`Ra1' Rb1' Ra2, Rb2, Ra3, Rb3, Ra4 ~ Rb4 ~ § 1Etlid-fum §~, m, Bf.'
`U~, 11~~' f£~, It~, C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 Bf 1~;l%~, C1-6 r£;l%~,
`C1-6 ;l%-~, C1-6 Bf 1~;l%-~, C2-6 '.);m~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~,
`
`10
`
`---1-d-"" i=r ,=,I';
`j;t, ---1-d-"" i=r
`-
`C6-10 n~.8-)<. 5-10 7G~7'Y~;
`
`15
`
`20
`
`25
`
`~~, Ra15f0 Rb1, Ra25f0 Rb2, Ra37f0 Rb3, Ra47f0 Rb4)j-JJiJ£5;f§~~B{JJJR-1-'fJ!1f
`
`%}J)G C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :JJ~~ 5-10 JG*:JJ~, ?fr;£ C3.s ;Ef;lJc~,
`
`3-8 5G*lf~, c6-10 :JJ~~ 5-10 5G*:JJ~, 1fms{JJ1t~:WiiBI•, •~, 11~~,
`f£~, It~, -1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 Bf 1~;l%~, C1-6 r£;l%~, C1-6
`;lJc-~, C1-6 Bf 1~;l%-~, C2-6 '.);m~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10
`
`:JJ~~ 5-10 5G*:JJ~~s{J~~~$~llR1~~?frllR1~:
`
`~,~~~~§¾~~m§~,m, BI•,u~,m~,r£~,tt~,•
`1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 Bf 1~;l%~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6
`BI1~;l%-~, C2-6 '.i:ffl~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :JJ~ 5-10
`5G*:JJ~, ?!rJ£B{]U~, C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 Bf 1~;l%~, C1-6 r£;l%~,
`C1-6 ;l%-~, C1-6 Bf 1~;l%-~, C2-6 '.);m~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~,
`c6-10 :JJ~~ 5-10 5G*:JJ~, 1fmB{JJ1t~:WiiBI., U~, 11~~, r£~, It~,
`-1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 Bf 1~;l%~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6
`BI1~;l%-~, C2-6 '.i:ffl~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :JJ~~ 5-10
`
`5G*:JJ~~ s{J~~~$~llR 1~~?frllR 1~:
`, R9 ~ R 10 ~§1Ee~f-fum§~, :m,, BJ., -~' 11~~' f£~, ft~,
`R7
`, R 8
`-1~~' C1-6 ;lJc~, C1-6 m1~;l%~, C1-6 Bf 1~;l%~, C1-6 r£;l%~, C1-6 ;lJc-~, C1-6
`BI1~;l%-~, C2-6 '.i:ffl~, C2-6 tR:~, C3.s ;Ef;lJc~, 3-8 5G*lf~, C6-10 :JJ~ 5-10
`5G*:JJ~, 1fmB{JJ1t~:WiiBI., U~, 11~~, r£~, It~, -1~~, C1-6;l%~,
`
`18
`
`Conjupro EX1006
`Page 21 of 373
`
`

`

`~ ~$~ llR 1~~?JrllR 1~:
`
`5
`
`nl 7'J 0-5 B{]~~o
`ft*~~fil-W~m~~~~A~,m~~A(ill)~~~:
`lf Am§ C3.glf;l%~~ *~ 1-3 ~N~ 0 ~ s JJR-=fs,g 3-8 5G*lf~~ C6-10
`7'J~~1,i~ 1-3 ~ N~ 0 ~ S JJR-=fB{] 5-10 JG*:lJ~;
`
`ft*~~fil-W~m~~~~A~, m~~A(ill)~~~:
`R 12 m § c1.3 ;tJc~;
`R 12 fil-W1Jtm E¥ ~ 0
`
`lf Am§ C3.12 ;Ef;lJc~~ 3-12 5G*lf~~ C6-14 :lY~~ 5-14 JG*:lY~;
`
`lf A 1Jtm C3.glf;l%~~ *~ 1-3 ~ N~ 0 ~ s JJR-=fs,g 3-10 5G*lf~~ C6-10
`7'J~~1,i~ 1-3 ~N~ 0 ~ S JJR-=fB{] 5-10 JG*:lJ~;
`
`20
`
`ft*~~fil-W1Jtms{]~~~A~, ?Jr~~A (II) 1t~tm:
`R 3 1JtmiC m~ ~~ ~ ~~~ 11~~~ f£~~ -~~ ~1~~~ C1.3 ;lJc~~ C1.3
`m1~;l%~~ C1.3 ~ 1~;l%~~ C1.3 r£;l%~~ C1.3 ;lJc~~~ C1.3 ~ 1~;l%~~~ C2.4 m~~
`
`C2.4 tR:~~ C3-6 ;Ef;lJc~~ 3-6 JG*lf~~ C6-10 7Y~~ 5-8 JG*:lY~~ -NS(O)Ra1Rb1 ~
`
`19
`
`Conjupro EX1006
`Page 22 of 373
`
`

`

`-(CH2)n1S(O)NRa2Rb2, -P(O) Ra3Rb3 ~-NRasS(O)NRa4Rb4, ?!rJ£B{]~~' C1.3 ;lJc~,
`C1.3 :JnJt;;lJc~, C1.3 Bf {~;lJc~, C1.3 r£;l%~, C1.3 ;lJc-~, C1.3 Bf {~;lJc-~, C2.4
`'.);m~, C2.4 tR:~, C3-6 ;Ef;l%~, 3-6 5G*lf~, C6-10 :7'J~~ 5-8 5G*:7'J~, 1fmB{]
`:Jtt-iviiBf~, ~~' 11~~' f£~, ft~, -1~~' -NS(O)Ra1Rb1, C1.3 ;lJc~,
`C1.3 m1~;l%~, C1.3 Bf {~;lJc~, C1.3 r£;l%~, C1.3 ;lJc-~, C1.3 Bf {~;lJc-~, C2.4
`
`5
`
`~ ~$~ llR 1~~?frllR 1~:
`R3 £ 1JtmiC m, Bf~' ~~' C1.3 ;l}G~, C1.3 m1~;l%~, C1.3 Bf 1~;l%~,
`-NS(O)Ra1Rb1, -(CH2)n1S(O)NRa2Rb2, -P(O)Ra3Rb3 ~-NRasS(O)NRa4Rb4, ?!rJ£B{]~
`10 ~' C1.3 ;lJc~, C1.3 m1~;l%~~ C1.3 Bf 1~;l%~, 1fmB{]:Jtt-iviiBI~' -NS(O)Ra1Rb1
`~ C1.3 ;lJc~~ s{]-~~$~1lR1~~?frllR1~o
`
`a*~~:Jtt-iv~m~~~~~~. mJ£~~crr)~~~=
`1Jtm±-fu' Ra1' Rb 1' Ra2' Rb2' Ra3' Rb3' Ra4 ~ Rb4 ~ § Mu1J-fum § ~' m'
`Bf~, ~~, C1.3 ;lJc~, C1.3 m1~;l%~~ C1.3 Bf 1~;l%~:
`:Jtt-iv{Jtmf-fu, Ra1, Rb1, Ra2