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`PROCESS FOR PRODUCING SLOWLY DRUG-RELEASING MICELLE USING
`CONJUGATION OF BIODEGRADABLE POLYMER AND ANTICANCER
`AGENT
`
`Publication number: KR20020041712 (A)
`Publication date:
`2002-06-03
`Inventor(s):
`PARK TAE GWAN [KR]; YOO HYEOK SANG [KR] +
`Applicant(s):
`KOREA ADVANCED INST SCI 8: TECH [KR] +
`Classification:
`
`A61K9/127; A61 K9I127; (IPC1-7): A61K9/127
`
`— international:
`- European:
`ApplicatiON number: KR20000071400 20001128
`Priority number(s): KR20000071400 20001128
`
`Abstract of KR 20020041712 (A)
`PURPOSE: A process for producing a slowly drug-releasing micelle using a conjugation of a
`biodegradable polymer and an anticancer agent is provided, thereby the drug releasing rate can be
`controlled, so that the slowly drug-releasing micelle can be useful for treatment of cancer.
`CONSTITUTION: The process for producing a slowly drug-releasing micelle using a conjugation of a
`biodegradable polymer and an anticancer agent comprises the steps of: copolymerizing a
`biodegradable polyester polymer and polyethyleneglyco|(PEG) in the presence of stannous octoate
`under vacuum condition at 160 to 200 deg.C for 2 to 6 hours to prepare a block copolymer having both
`hydrophobic region and hydrophilic region, wherein the end of the hydrophobic region has hydroxy
`group; dissolving the block copolymer in an organic solvent, reacting the block copolymer with a linker
`compound in the presence of pyridine and nitrogen to combine the linker compound with the hydroxy
`group of the block copolymer; reacting the block copolymer with hydrazine and combining the block
`copolymer with a drug to prepare a micelle unit: and dispersing the micelle unit in an aqueous solution.
`
`
`Data supplied from the espacenet database —— Worldwide
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`http://VS .espacenet.com/publicationDctails/biblio?DB=EPODOC&adj accnt=true&loca] e...
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`05/27/2010
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