SEQUENCE LISTING
`
`<110> McMaster University
`
`<120> Method of Diagnosing and Monitoring Inflammatory Disease
`
`Progression
`
`<130> GWLG— 017US—CIP
`
`<l40> US 15/632,497
`<141> 2017—
`06—26
`
`<160> 22
`
`<170> PatentIn version 3.3
`
`<210>
`
`l
`
`<le> 72
`
`<212> PRT
`
`<Zl3> Homo
`
`<400>
`
`1
`
`sapiens
`
`Ala Val Asp
`1
`
`Met Ser Gly Gly Thr
`5
`
`Val Thr Val Leu Glu Lys Val Pro
`10
`15
`
`Val Ser Lys
`
`Gly Gln Leu Lys Gln
`20
`
`Tyr Phe Tyr Glu Thr Lys Cys Asn
`25
`30
`
`Pro Met Gly
`35
`
`Tyr Thr Lys Glu Gly
`40
`
`Cys Arg Gly Ile Asp Lys Arg His
`45
`
`Trp Asn Ser
`50
`
`Gln Cys Arg Thr Thr
`55
`
`Gln Ser Tyr Val Arg Ala Leu Thr
`60
`
`Met Asp Ser
`65
`
`Lys Lys Arg Ile Gly
`70
`
`<210> Z
`
`<le> 70
`
`<212> PRT
`
`
`
`<110> McMaster University
`
`<120> Method of Diagnosing and Monitoring Inflammatory Disease
`
`Progression
`
`<130> GWLG— 017US—CIP
`
`<l40> US 15/632,497
`<141> 2017—
`06—26
`
`<160> 22
`
`<170> PatentIn version 3.3
`
`<210>
`
`l
`
`<le> 72
`
`<212> PRT
`
`<Zl3> Homo
`
`<400>
`
`1
`
`sapiens
`
`Ala Val Asp
`1
`
`Met Ser Gly Gly Thr
`5
`
`Val Thr Val Leu Glu Lys Val Pro
`10
`15
`
`Val Ser Lys
`
`Gly Gln Leu Lys Gln
`20
`
`Tyr Phe Tyr Glu Thr Lys Cys Asn
`25
`30
`
`Pro Met Gly
`35
`
`Tyr Thr Lys Glu Gly
`40
`
`Cys Arg Gly Ile Asp Lys Arg His
`45
`
`Trp Asn Ser
`50
`
`Gln Cys Arg Thr Thr
`55
`
`Gln Ser Tyr Val Arg Ala Leu Thr
`60
`
`Met Asp Ser
`65
`
`Lys Lys Arg Ile Gly
`70
`
`<210> Z
`
`<le> 70
`
`<212> PRT
`
`
`
`<213> Homo sapiens
`
`<400> 2
`
`Ser Ile Thr Leu Ser Cys
`1
`5
`
`Ser Val Ala Gly Asp
`10
`
`Pro Val Pro Asn
`
`Met
`
`15
`
`Tyr Trp Asp Val Gly Asn
`20
`
`Leu Val Ser Lys His
`25
`
`Met Asn Glu Thr
`
`Ser
`
`30
`
`His Thr Gln Gly Ser Leu
`35
`
`Arg Ile Thr Asn Ile
`40
`
`Ser Ser Asp Asp
`45
`
`Ser
`
`Gly Lys Gln Ile Ser Cys
`50
`
`Val Ala Glu Asn Leu
`
`55
`
`Val Gly Glu Asp
`60
`
`Gln
`
`Asp Ser Val Asn Leu Thr
`65
`70
`
`<210> 3
`
`<211> 71
`
`<212> PRT
`
`<213> Mus sp.
`
`<400> 3
`
`Lys Ser Val Thr Leu Ser
`1
`5
`
`Cys Ser Val Gly Gly
`10
`
`Asp Pro Leu Pro
`15
`
`Thr
`
`Leu Tyr Trp Asp Val Gly
`20
`
`Asn Leu Val Ser Lys
`25
`
`His Met Asn Glu
`
`Thr
`
`30
`
`Ser His Thr Gln Gly Ser
`35
`
`Leu Arg Ile Thr Asn
`40
`
`Ile Ser Ser Asp
`45
`
`Asp
`
`Ser Gly Lys Gln Ile Ser
`50
`
`Cys Val Ala Glu Asn
`55
`
`Leu Val Gly Glu
`60
`
`Asp
`
`
`
`Gln Asp Ser Val Asn Leu Thr
`65
`70
`
`<210> 4
`
`<le> 70
`
`<212> PRT
`
`<Zl3> Rattus sp.
`
`<400> 4
`
`Ser Val Thr Ile Ser Cys Ser Val Gly Gly Asp Pro Leu Pro Thr Leu
`1
`5
`10
`15
`
`Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met Asn Glu Thr Ser
`20
`25
`30
`
`His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser Ser Asp Asp Ser
`35
`40
`45
`
`Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val Gly Glu Asp Gln
`50
`55
`60
`
`Asp Ser Val Asn Leu Thr
`65
`70
`
`<210> 5
`
`<le> 219
`
`<212> DNA
`
`<Zl3> Homo sapiens
`
`<400> 5
`
`tgcagtggac atgtcgggcg ggacggtcac agtccttgaa aaggtccctg tatcaaaagg
`
`60
`
`ccaactgaag caatacttct acgagaccaa gtgcaatccc atgggttaca caaaagaagg
`
`120
`
`ctgcaggggc atagacaaaa ggcattggaa ctcccagtgc cgaactaccc agtcgtacgt
`
`180
`
`gcgggccctt accatggata gcaaaaagag aattggctg
`
`219
`
`
`
`<210> 6
`
`<211> 216
`
`<212> DNA
`
`<213> Mus
`
`sp.
`
`<400> 6
`
`tgcagtggac
`
`atgtctggcg
`
`ggacggtcac
`
`agtcctagag aaagtcccgg tatccaaagg
`
`ccaactgaag
`
`cagtatttct
`
`acgagaccaa
`
`gtgtaatccc atgggttaca ccaaggaagg
`
`ctgcaggggc
`
`atagacaaaa
`
`ggcactggaa
`
`ctcgcaatgc cgaactaccc aatcgtatgt
`
`tcgggccctt
`
`actatggata
`
`gcaaaaagag
`
`aattgg
`
`<210> 7
`
`<211> 219
`
`<212> DNA
`
`<213>
`
`Rattus sp.
`
`<400> 7
`
`tgcagtggac
`
`atgtccggtg
`
`ggacggtcac
`
`agtcctggag aaagtcccgg tatcaaaagg
`
`ccaactgaag
`
`caatatttct
`
`acgagaccaa
`
`gtgtaatccc atgggttaca cgaaggaagg
`
`ctgcaggggc
`
`atagacaaaa
`
`ggcactggaa
`
`ctcgcaatgc cgaactaccc aatcgtatgt
`
`tcgggccctt
`
`actatggata
`
`gcaaaaagag
`
`aattggctg
`
`<210> 8
`
`<211> 210
`
`<212> DNA
`
`<213>
`
`Homo sapiens
`
`<400> 8
`
`gtctatcaca
`
`ttatcctgta
`
`QtQtQQCGQQ
`
`tgatccggtt cctaatatgt attgggatgt
`
`tggtaacctg
`
`gtttccaaac
`
`atatgaatga
`
`aacaagccac acacagggct ccttaaggat
`
`aactaacatt
`
`tcatccgatg
`
`acagtgggaa
`
`gcagatctct tgtgtggcgg aaaatcttgt
`
`aggagaagat
`
`caagattctg
`
`tcaacctcac
`
`60
`
`120
`
`180
`
`216
`
`60
`
`120
`
`180
`
`219
`
`60
`
`120
`
`180
`
`210
`
`
`
`<210> 9
`
`<le> 20
`
`<212> DNA
`
`<Zl3> Artificial
`
`<220>
`
`<ZZ3> Primer
`
`<400> 9
`
`gagctgagcg tgtgtgacag
`
`<210>
`
`10
`
`<le> 20
`
`<212> DNA
`
`<Zl3> Artificial
`
`<220>
`
`<ZZ3> Primer
`
`<400>
`
`10
`
`cttatgaatc gccagccaat
`
`<210>
`
`11
`
`<le> 20
`
`<212> DNA
`
`<Zl3> Artificial
`
`<220>
`
`<ZZ3> Primer
`
`<400>
`
`11
`
`caattgtggt ttgccatctg
`
`<210>
`
`12
`
`<le> 20
`
`<212> DNA
`
`<Zl3> Artificial
`
`<220>
`
`<ZZ3> Primer
`
`<400>
`
`12
`
`tgcaaaatgc acagtgaggt
`
`20
`
`20
`
`20
`
`20
`
`
`
`<210>
`
`13
`
`<211>
`
`<212>
`
`<213>
`
`158
`
`PRT
`
`Homo sapiens
`
`<400>
`
`13
`
`Met Leu
`
`Cys Leu
`
`Leu Leu
`
`Thr Leu
`
`5
`
`Gly Val Ala
`10
`
`Leu
`
`Val Cys
`
`Val
`
`Gly
`15
`
`Pro Ala
`
`Met Asp
`20
`
`Ile Pro
`
`Gln Thr
`
`Lys Gln Asp
`25
`
`Leu
`
`Glu Leu
`
`Pro
`
`Lys
`
`30
`
`Ala Pro
`
`Leu Arg
`35
`
`Val His
`
`Ile Thr
`
`Ser Leu Leu
`
`Pro
`
`Thr Pro
`
`Glu
`
`Asp
`
`40
`
`45
`
`Asn Leu
`
`Glu Ile
`
`Val Leu
`
`50
`
`His Arg
`55
`
`Trp Glu Asn
`
`Asn
`
`60
`
`Ser Cys
`
`Val
`
`Glu
`
`Val Leu
`
`Glu Asn Pro
`
`Lys
`
`Lys
`
`Ile
`
`Lys Lys
`65
`
`Gly Glu
`70
`
`Lys Thr
`
`Lys Phe
`
`75
`
`80
`
`Asn Tyr
`
`Thr Val
`
`Ala Asn
`
`Glu Ala
`
`Thr Leu Leu
`
`85
`
`90
`
`Asp
`
`Thr Asp
`
`Asp
`
`Tyr
`95
`
`Asn Phe
`
`Leu Phe
`
`Leu Cys
`
`Leu Gln
`
`100
`
`Asp Thr Thr
`105
`
`Thr
`
`Pro Ile
`
`Gln
`
`Ser
`
`110
`
`Met Met
`
`Cys Gln
`115
`
`Tyr Leu
`
`Ala Arg
`120
`
`Val Leu Val
`
`Glu
`
`Glu
`
`Ile
`
`Asp Asp
`125
`
`Met Gln
`
`Gly Phe
`
`Ile Arg
`
`Ala Phe
`
`Arg Pro Leu
`
`130
`
`135
`
`Arg His
`
`Leu
`
`Trp
`
`Pro
`
`140
`
`Tyr Leu
`
`Leu Asp
`
`Leu Lys
`
`Gln Met
`
`Glu Glu Pro
`
`Cys
`
`Arg Phe
`
`
`
`145
`
`150
`
`155
`
`<210>
`
`14
`
`<211>
`
`<212>
`
`<213>
`
`180
`
`PRT
`
`Homo sapiens
`
`<400>
`
`14
`
`Met Leu Cys Leu
`1
`
`Leu Leu Thr Leu
`
`Gly
`
`Val Ala Leu
`
`Val
`
`Cys
`
`5
`
`10
`
`Gly Val
`15
`
`Pro Ala Met Asp
`20
`
`Ile Pro Gln Thr
`
`Gln Asp Leu
`
`Glu
`
`Lys
`25
`
`Leu
`
`30
`
`Pro Lys
`
`Leu Ala
`
`Thr
`
`Gly
`35
`
`Trp His Ser Met
`40
`
`Ala Met Ala Thr Asn
`
`Asn
`
`Ile Ser
`
`45
`
`Leu
`
`Met
`
`Ala Thr
`
`50
`
`Leu Lys Ala Pro
`55
`
`Leu Arg Val His Ile
`60
`
`Thr
`
`Ser Leu
`
`Leu Pro Thr Pro
`
`65
`
`Glu Asp Asn Leu
`70
`
`Glu Ile Val Leu
`
`His
`
`Arg
`
`Trp
`
`75
`
`Glu
`
`80
`
`Asn Asn Ser Cys
`
`Val Glu Lys Lys
`85
`
`Val Leu Gly Glu
`90
`
`Lys
`
`Thr
`
`Glu
`
`Asn
`
`95
`
`Pro Lys Lys
`
`Phe
`
`100
`
`Lys Ile Asn Tyr
`
`Thr
`
`Val Ala Asn Glu
`
`Ala
`
`Thr Leu
`
`105
`
`110
`
`Leu Asp
`
`Thr
`
`115
`
`Asp
`
`Tyr Asp Asn Phe
`120
`
`Leu Phe Leu Cys
`
`Leu
`
`Gln
`
`Asp Thr
`
`125
`
`Thr Thr
`
`Pro Ile
`
`Gln Ser Met Met
`
`130
`
`135
`
`Cys Gln Tyr Leu Ala
`140
`
`Arg
`
`Val Leu
`
`
`
`Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro
`145
`155
`150
`160
`
`Leu Pro Arg
`
`His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu
`175
`165
`170
`
`Pro Cys Arg
`
`Phe
`
`180
`
`<210>
`
`15
`
`<211>
`
`<212>
`
`180
`
`PRT
`
`<213>
`
`Homo
`
`sapiens
`
`<400>
`
`15
`
`Met Leu Cys
`1
`
`Leu Leu Leu
`
`Thr Leu Gly
`
`Val Ala Leu
`
`Val
`
`5
`
`10
`
`Cys
`
`Gly Val
`15
`
`Pro Ala Met
`
`Asp Ile Pro
`20
`
`Gln Thr Lys
`25
`
`Gln Asp Leu
`
`Glu
`
`Leu
`
`Pro Lys
`
`30
`
`Leu Ala Gly
`35
`
`Thr Trp His
`
`Ser Met Ala
`
`Met Ala Thr
`
`Asn
`
`Asn
`
`Ile Ser
`
`40
`
`45
`
`Leu Met Ala
`
`Thr Leu Lys
`
`Ala Pro Leu
`
`50
`
`55
`
`Arg Val His
`60
`
`Ile
`
`Thr
`
`Ser Leu
`
`Leu Pro Thr
`
`65
`
`Pro Glu Asp
`70
`
`Asn Leu Glu
`
`Ile Val Leu
`
`His
`
`75
`
`Arg
`
`Trp Glu
`80
`
`Asn Asn Ser
`
`Cys Val Glu
`85
`
`Lys Lys Val
`
`Leu Gly Glu
`90
`
`Lys
`
`Thr
`
`Glu
`
`Asn
`
`95
`
`Pro Lys Lys
`
`Phe Lys Ile
`100
`
`Asn Tyr
`
`Thr
`
`Val Ala Asn
`
`Glu
`
`Ala
`
`Thr Leu
`
`105
`
`110
`
`
`
`Leu Asp Thr
`115
`
`Asp Tyr
`
`Asp Asn Phe
`120
`
`Leu Phe Leu
`
`Cys Leu
`125
`
`Gln Asp Thr
`
`Thr Thr Pro
`
`Ile Gln
`
`Ser Met Met
`
`Cys Gln Tyr
`
`130
`
`135
`
`Leu Ala
`
`140
`
`Arg Val Leu
`
`Val
`
`145
`
`Glu Asp
`
`Asp Glu
`
`Ile Met Gln
`
`150
`
`Gly Phe Ile
`155
`
`Arg Ala
`
`Phe Arg Pro
`160
`
`Leu Pro Arg
`
`His
`
`Leu
`
`165
`
`Trp Tyr Leu
`
`Leu Asp Leu
`170
`
`Lys Gln
`
`Met Glu Glu
`
`175
`
`Pro Cys Arg
`
`Phe
`
`180
`
`<210>
`
`16
`
`<211>
`
`<212>
`
`830
`
`DNA
`
`<213>
`
`Homo
`
`sapiens
`
`<400>
`
`16
`
`agcatccctc
`
`tggctccaga
`
`gctcagagcc
`
`acccacagcc
`
`gcagccatgc
`
`tgtgcctcct
`
`tQQtCtQtQQ
`
`tgtcccggcc
`
`atggacatcc
`
`cccagaccaa
`
`60
`
`120
`
`gctcaccctg
`
`QQCQtQQCCC
`
`gcaggacctg
`
`gagctcccaa
`
`GQttQQCGQQ
`
`gacctggcac
`
`tccatggcca
`
`tggcgaccaa
`
`caacatctcc
`
`ctcatggcga
`
`cactgaaggc
`
`ccctctgagg
`
`gtccacatca
`
`cctcactgtt
`
`gcccaccccc
`
`gaggacaacc
`
`tggagatcgt
`
`tctgcacaga
`
`tgggagaaca
`
`acagctgtgt
`
`180
`
`240
`
`300
`
`tgagaagaag
`
`gtccttggag
`
`agaagactga
`
`gaatccaaag
`
`aagttcaaga
`
`tcaactatac
`
`360
`
`QQtQQCQGGC
`
`gaggccacgc
`
`tgctcgatac
`
`tgactacgac
`
`aatttcctgt
`
`ttctctgcct
`
`acaggacacc
`
`accaccccca
`
`tccagagcat
`
`gatgtgccag
`
`tacctggcca
`
`gagtcctggt
`
`QQGQQGCQGt
`
`gagatcatgc
`
`agggattcat
`
`cagggctttc
`
`aggcccctgc
`
`ccaggcacct
`
`atggtacttg
`
`ctggacttga
`
`aacagatgga
`
`agagccgtgc
`
`cgtttctagc
`
`tcacctccgc
`
`420
`
`480
`
`540
`
`600
`
`
`
`ctccaggaag
`
`accagactcc
`
`cacccttcca
`
`cacctccaga
`
`gcagtgggac
`
`ttcctcctgc
`
`cctttcaaag
`
`aataaccaca
`
`gctcagaaga
`
`cgatgacgtg
`
`gtcatctgtg
`
`tcgccatccc
`
`cttcctgctg
`
`cacacctgca
`
`ccacggccat
`
`QQQQGQQCtQ
`
`ctccctgggg
`
`gcagagtctc
`
`tQQCGQGQQt
`
`tattaataaa
`
`cccttggagc
`
`atgaaaaaaa
`
`GOGGGGGGGG
`
`<210>
`
`17
`
`<le>
`
`<212>
`
`<Zl3>
`
`830
`
`DNA
`
`Homo sapiens
`
`<400>
`
`l7
`
`agcatccctc
`
`tggctccaga
`
`gctcagagcc
`
`acccacagcc
`
`gcagccatgc
`
`tgtgcctcct
`
`gctcaccctg
`
`QQCQtQQCCC
`
`tQQtCtQtQQ
`
`tgtcccggcc
`
`atggacatcc
`
`cccagaccaa
`
`gcaggacctg
`
`gagctcccaa
`
`GQttQQCGQQ
`
`gacctggcac
`
`tccatggcca
`
`tggcgaccaa
`
`caacatctcc
`
`ctcatggcga
`
`cactgaaggc
`
`ccctctgagg
`
`gtccacatca
`
`cctcactgtt
`
`gcccaccccc
`
`gaggacaacc
`
`660
`
`720
`
`780
`
`830
`
`60
`
`120
`
`180
`
`240
`
`300
`
`tggagatcgt
`
`tctgcacaga
`
`tgggagaaca
`
`acagctgtgt
`
`tgagaagaag
`
`gtccttggag
`
`agaagactga
`
`gaatccaaag
`
`aagttcaaga
`
`tcaactatac
`
`360
`
`QQtQQCQGGC
`
`gaggccacgc
`
`tgctcgatac
`
`tgactacgac
`
`aatttcctgt
`
`ttctctgcct
`
`acaggacacc
`
`accaccccca
`
`tccagagcat
`
`gatgtgccag
`
`tacctggcca
`
`gagtcctggt
`
`ggaggacgat
`
`gagatcatgc
`
`agggattcat
`
`cagggctttc
`
`aggcccctgc
`
`ccaggcacct
`
`atggtacttg
`
`ctggacttga
`
`aacagatgga
`
`agagccgtgc
`
`cgtttctagc
`
`tcacctccgc
`
`ctccaggaag
`
`accagactcc
`
`cacccttcca
`
`cacctccaga
`
`QCGQtQQQGC
`
`ttcctcctgc
`
`cctttcaaag
`
`aataaccaca
`
`gctcagaaga
`
`cgatgacgtg
`
`gtcatctgtg
`
`tcgccatccc
`
`cttcctgctg
`
`cacacctgca
`
`ccacggccat
`
`QQQQGQQCtQ
`
`ctccctgggg
`
`gcagagtctc
`
`tQQCGQGQQt
`
`tattaataaa
`
`cccttggagc
`
`atgaaaaaaa
`
`GOGGGGGGGG
`
`420
`
`480
`
`540
`
`600
`
`660
`
`720
`
`780
`
`830
`
`<210>
`
`l8
`
`
`
`<le>
`
`<212>
`
`<Zl3>
`
`859
`
`DNA
`
`Homo sapiens
`
`<400>
`
`l8
`
`agcatccctc
`
`tggctccaga
`
`gctcagagcc
`
`acccacagcc
`
`gcagccatgc
`
`tgtgcctcct
`
`gctcaccctg
`
`QQCQtQQCCC
`
`tQQtCtQtQQ
`
`tgtcccggcc
`
`atggacatcc
`
`cccagaccaa
`
`gcaggacctg
`
`gagctcccaa
`
`agttggcagg
`
`gacctggcac
`
`tccatggcca
`
`tggcgaccaa
`
`caacatctcc
`
`ctcatggcga
`
`cactgaaggc
`
`ccctctgagg
`
`gtccacatca
`
`cctcactgtt
`
`gcccaccccc
`
`gaggacaacc
`
`tggagatcgt
`
`tctgcacaga
`
`tgggagaaca
`
`acagctgtgt
`
`60
`
`120
`
`180
`
`240
`
`300
`
`tgagaagaag
`
`gtccttggag
`
`agaagactga
`
`gaatccaaag
`
`aagttcaaga
`
`tcaactatac
`
`360
`
`QQtQQCQGGC
`
`gaggccacgc
`
`tgctcgatac
`
`tgactacgac
`
`aatttcctgt
`
`ttctctgcct
`
`acaggacacc
`
`accaccccca
`
`420
`
`480
`
`tccagagcat
`
`gatgtgccag
`
`tacctggcca
`
`gagtcctggt
`
`QQGQQGCQGt
`
`gagatcatgc
`
`agggattcat
`
`cagggctttc
`
`aggcccctgc
`
`ccaggcacct
`
`atggtacttg
`
`ctggacttga
`
`aacagatgga
`
`agagccgtgc
`
`cgtttctagg
`
`tgagctcctg
`
`540
`
`600
`
`cctggtcctg
`
`cctcctggct
`
`cacctccgcc
`
`tccaggaaga
`
`ccagactccc
`
`acccttccac
`
`660
`
`acctccagag
`
`cagtgggact
`
`tcctcctgcc
`
`ctttcaaaga
`
`ataaccacag
`
`ctcagaagac
`
`QGtQGCQtQQ
`
`tcatctgtgt
`
`cgccatcccc
`
`ttcctgctgc
`
`acacctgcac
`
`cacggccatg
`
`QQQGQQCtQC
`
`tccctggggg
`
`cagagtctct
`
`ggcagaggtt
`
`attaataaac
`
`ccttggagca
`
`tgaaaaaaaa
`
`ClClClClClClClClCl
`
`<210>
`
`19
`
`<le>
`
`<212>
`
`<Zl3>
`
`Z98
`
`PRT
`
`Homo sapiens
`
`<400>
`
`l9
`
`720
`
`780
`
`840
`
`859
`
`Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly
`l
`5
`15
`10
`
`
`
`Pro
`
`Ala
`
`Val Pro
`
`Gln Glu
`
`Asn
`
`20
`
`Gln Asp
`25
`
`Gly
`
`Arg
`
`Tyr
`
`Ser
`
`Leu Thr
`
`Tyr
`
`30
`
`Ile
`
`Tyr
`
`Thr Gly
`35
`
`Leu Ser
`
`Lys
`
`His Val
`
`Glu
`
`Asp
`
`Val
`
`Pro
`
`Ala Phe
`
`Gln
`
`40
`
`45
`
`Ala
`
`Leu
`
`Gly Ser
`
`Leu Asn
`
`50
`
`Asp
`55
`
`Leu Gln
`
`Phe
`
`Phe
`
`Tyr
`
`Asn Ser
`
`Lys
`
`Arg
`60
`
`Asp
`65
`
`Arg
`
`Lys Ser
`
`Gln Pro
`
`Met
`
`Gly Leu
`
`Trp
`
`70
`
`Arg
`75
`
`Gln
`
`Val
`
`Glu Gly
`
`Met
`
`80
`
`Glu
`
`Asp
`
`Trp Lys
`
`Gln Asp
`85
`
`Ser
`
`Gln Leu
`
`Gln
`
`Lys
`
`Ala
`
`Arg
`
`90
`
`Ile
`
`Glu Asp
`95
`
`Phe
`
`Met
`
`Glu Thr
`
`Ile Val
`
`Glu
`
`Tyr
`
`Tyr
`
`Asn
`
`Asn
`
`Leu Lys
`
`Asp
`
`100
`
`105
`
`Asp Ser
`110
`
`Gly
`
`Ser
`
`His Val
`
`Leu Gln
`
`115
`
`Gly
`
`Arg Phe
`120
`
`Gly
`
`Cys
`
`Glu
`
`Ile
`
`Glu Asn
`
`Asn
`
`125
`
`Arg
`
`Ser
`
`130
`
`Ser Gly
`
`Ala Phe
`
`Trp
`135
`
`Lys Tyr
`
`Tyr
`
`Tyr
`
`Asp
`140
`
`Gly
`
`Lys Asp
`
`Tyr
`
`Ile
`
`Glu
`
`Phe Asn
`
`145
`
`Lys Glu
`150
`
`Ile
`
`Pro Ala
`
`Trp
`
`Val
`
`Pro
`
`Phe
`
`Asp Pro
`
`155
`
`Ala
`
`160
`
`Ala
`
`Gln
`
`Ile Thr
`
`Lys Gln
`165
`
`Lys
`
`Trp Glu
`
`Ala
`
`Glu Pro Val
`
`170
`
`Gln
`
`Tyr Val
`175
`
`Arg
`
`Ala
`
`Lys Ala
`180
`
`Tyr Leu
`
`Glu
`
`Glu Glu
`
`Cys Pro Ala Thr
`
`185
`
`Leu Arg
`190
`
`Lys
`
`Tyr
`
`Leu
`
`Lys Tyr
`
`Ser Lys
`
`Asn
`
`Ile Leu
`
`Asp Arg Gln Asp
`
`Pro Pro
`
`Ser
`
`
`
`195
`
`200
`
`205
`
`Val Val Val
`
`Thr Ser
`
`His
`
`Gln Ala
`
`210
`
`215
`
`Pro Gly Glu
`
`Lys Lys
`220
`
`Lys
`
`Leu Lys
`
`Cys Leu Ala
`225
`
`Tyr Asp
`
`Phe
`
`230
`
`Tyr Pro
`
`Gly Lys Ile
`235
`
`Asp Val His
`
`Trp Thr
`240
`
`Arg
`
`Ala Gly Glu Val
`245
`
`Gln
`
`Glu Pro
`
`Glu Leu Arg
`250
`
`Gly Asp Val
`
`Leu His
`
`255
`
`Asn Gly Asn
`
`Gly Thr
`260
`
`Tyr
`
`Gln Ser
`
`Trp Val Val
`265
`
`Val Ala Val
`
`Pro Pro
`
`270
`
`Gln Asp Thr
`275
`
`Ala Pro
`
`Tyr
`
`Ser Cys
`280
`
`His Val Gln
`
`His Ser Ser
`
`Leu Ala
`
`285
`
`Gln Pro Leu
`
`Val Val
`
`Pro
`
`290
`
`Ala Ser
`
`Trp Glu
`295
`
`<210>
`
`20
`
`<211>
`
`1278
`
`<212>
`
`DNA
`
`<213>
`
`Homo
`
`sapiens
`
`<400> 20
`
`ccattggcct
`
`gtagattcac
`
`ctcccctggg
`
`cagggcccca
`
`ggacccagga
`
`taatatctgt
`
`gcctcctgcc
`
`cagaaccctc
`
`caagcagaca
`
`caatggtaag
`
`aatggtgcct
`
`gtcctgctgt
`
`ctctgctgct
`
`gcttctgggt
`
`cctgctgtcc
`
`cccaggagaa
`
`ccaagatggt
`
`cgttactctc
`
`tgacctatat
`
`ctacactggg
`
`ctgtccaagc
`
`atgttgaaga
`
`cgtccccgcg
`
`tttcaggccc
`
`ttggctcact
`
`caatgacctc
`
`cagttcttta
`
`gatacaacag
`
`taaagacagg
`
`aagtctcagc
`
`ccatgggact
`
`ctggagacag
`
`QtQQGGQQGG
`
`tggaggattg
`
`gaagcaggac
`
`agccaacttc
`
`agaaggccag
`
`ggaggacatc
`
`tttatggaga
`
`ccctgaaaga
`
`catcgtggag
`
`tattacaacg
`
`60
`
`120
`
`180
`
`240
`
`300
`
`360
`
`420
`
`
`
`acagtaacgg
`
`gtctcacgta
`
`ttgcagggaa
`
`ggtttggttg
`
`tgagatcgag
`
`aataacagaa
`
`QCGQCQQGQC
`
`attctggaaa
`
`tattactatg
`
`atggaaagga
`
`ctacattgaa
`
`ttcaacaaag
`
`aaatcccagc
`
`ctgggtcccc
`
`ttcgacccag
`
`cagcccagat
`
`aaccaagcag
`
`GGQtQQQGQQ
`
`cagaaccagt
`
`ctacgtgcag
`
`CQQQCCGGQQ
`
`cttacctgga
`
`QQGQQGQtQC
`
`cctgcgactc
`
`tgcggaaata
`
`cctgaaatac
`
`agcaaaaata
`
`tcctggaccg
`
`gcaagatcct
`
`ccctctgtgg
`
`tggtcaccag
`
`ccaccaggcc
`
`ccaggagaaa
`
`agaagaaact
`
`gaagtgcctg
`
`gcctacgact
`
`tctacccagg
`
`gaaaattgat
`
`gtgcactgga
`
`CtCQQQCCQQ
`
`cgaggtgcag
`
`gagcctgagt
`
`tGCQQQQGQG
`
`tgttcttcac
`
`aatggaaatg
`
`gcacttacca
`
`QtCCtQQQtQ
`
`QtQQtQQCGQ
`
`480
`
`540
`
`600
`
`660
`
`720
`
`780
`
`840
`
`900
`
`ccctactcct
`
`tgcccccgca
`
`ggacacagcc
`
`gccacgtgca
`
`gcacagcagc
`
`ctggcccagc
`
`ccctcgtggt
`
`QCCCtQQQGQ
`
`gccagctagg
`
`aagcaagggt
`
`tggaggcaat
`
`gtgggatctc
`
`agacccagta
`
`gctgcccttc
`
`ctgcctgatg
`
`tgggagctga
`
`accacagaaa
`
`tcacagtcaa
`
`tggatccaca
`
`GQQCCtQGQQ
`
`agcagtgtgg
`
`QQQQGCGQGC
`
`GQQGQQtQQG
`
`tttggagacc
`
`QGGQGCtQQQ
`
`atgcctgtct
`
`tgagtagact
`
`tggacccaaa
`
`aaatcatctc
`
`accttgagcc
`
`cacccccacc
`
`ccattgtcta
`
`atctgtagaa
`
`gctaataaat
`
`aatcatccct
`
`ccttgcctag
`
`cataaaaaaa
`
`ClClClClClClClCl
`
`<210>
`
`21
`
`<211>
`
`<212>
`
`<213>
`
`307
`
`PRT
`
`Mus
`
`sp.
`
`<400> 21
`
`960
`
`1020
`
`1080
`
`1140
`
`1200
`
`1260
`
`1278
`
`Met Val Pro Val Leu Leu Ser Leu Pro Leu Leu Leu Gly Pro Ala Val
`1
`5
`15
`10
`
`Phe Gln Glu Thr Gly Ser Tyr Tyr Leu Thr Phe Leu Tyr Thr Gly Leu
`20
`25
`30
`
`
`
`Ser Arg
`
`Pro
`
`Ser
`
`Lys
`
`Gly
`
`Phe
`
`Pro
`
`Arg
`
`Phe
`
`Gln
`
`Ala
`
`Thr
`
`Ala
`
`Phe
`
`Leu
`
`35
`
`40
`
`45
`
`Asn Asp
`50
`
`Gln
`
`Ala
`
`Phe
`
`Phe
`
`His
`
`Tyr
`
`Asn
`
`Ser
`
`Asn
`
`Ser
`
`Gly
`
`Lys
`
`Ala
`
`Glu
`
`55
`
`60
`
`Pro Val
`
`Gly
`
`Pro
`
`Trp
`
`Ser
`
`Gln
`
`Val
`
`Glu
`
`Gly
`
`Met
`
`Glu
`
`Asp
`
`Trp
`
`Glu
`
`75
`
`Lys
`80
`
`65
`
`70
`
`Glu Ser
`
`Gln
`
`Leu
`
`Gln
`
`Arg
`
`Ala
`
`Arg
`
`Glu
`
`Glu
`
`Ile
`
`Phe
`
`Leu
`
`Val
`
`Thr
`
`Leu
`
`85
`
`90
`
`95
`
`Lys Asp
`
`Ile
`
`Met
`
`Asp
`
`Tyr
`
`Tyr
`
`Lys
`
`100
`
`Asp
`105
`
`Thr
`
`Thr
`
`Gly
`
`Ser
`
`His
`
`Thr
`
`Phe
`
`110
`
`Met
`
`Phe
`
`Gly
`
`Cys
`
`Glu
`
`Ile
`
`Thr
`
`Asn
`
`Asn
`
`Arg
`
`Ser
`
`Ser
`
`Gly
`
`Ala
`
`Gln Gly
`
`115
`
`120
`
`125
`
`Val Trp
`130
`
`Arg
`
`Tyr
`
`Ala
`
`Tyr
`
`Asp
`135
`
`Gly
`
`Glu
`
`Asp
`
`Phe
`
`Ile
`
`Glu
`
`Phe
`
`Asn
`
`Lys
`
`140
`
`Glu Ile
`
`Pro
`
`Ala
`
`Trp
`
`Ile
`
`Pro
`
`Leu
`
`Asp
`
`Pro
`
`Ala
`
`Ala
`
`Ala
`
`Asn
`
`Thr
`
`145
`
`150
`
`155
`
`Lys
`160
`
`Glu
`
`Ala
`
`Glu
`
`Lys
`
`Val
`
`Tyr
`
`Val
`
`Gln
`
`Arg
`
`Ala
`
`Lys
`
`Ala
`
`Tyr
`
`Leu Lys
`
`Trp
`
`165
`
`170
`
`175
`
`Leu Glu
`
`Glu
`
`Glu
`
`Cys
`
`Pro
`
`Glu
`
`Met
`
`Leu
`
`Lys
`
`Arg
`
`Tyr
`
`Leu
`
`Asn
`
`Tyr
`
`Ser
`
`180
`
`185
`
`190
`
`Arg Ser
`
`His
`
`Leu
`
`Asp
`
`Arg
`
`Ile
`
`195
`
`Asp
`200
`
`Pro
`
`Pro
`
`Thr
`
`Val
`
`Thr
`
`Ile
`
`Thr
`
`Ser
`
`205
`
`Arg Val
`
`Ile
`
`Pro
`
`Gly Gly Asn
`
`Arg
`
`Ile Phe Lys
`
`Cys
`
`Leu
`
`Ala
`
`Tyr
`
`Gly
`
`
`
`210
`
`215
`
`220
`
`Phe
`
`225
`
`Tyr
`
`Pro Gln Arg Ile Ser
`230
`
`Leu
`
`His Trp Asn
`235
`
`Lys Ala Asn
`
`Lys Lys
`240
`
`Leu Ala Phe
`
`Glu Pro Glu Arg
`245
`
`Gly Val Phe
`250
`
`Pro
`
`Asn Gly Asn
`
`Gly Thr
`255
`
`Tyr Leu Ser
`
`Trp Ala Glu Val
`260
`
`Glu Val Ser
`
`Pro
`
`Gln Asp
`
`265
`
`Ile
`
`270
`
`Asp Pro
`
`Phe Phe Cys
`Z75
`
`Leu Ile Asp His
`
`Arg
`280
`
`Gly Phe Ser
`
`Gln Ser
`
`Leu
`
`Ser Val
`
`285
`
`Gln Trp
`290
`
`Asp Arg Thr Arg Lys
`295
`
`Val
`
`Lys Asp Glu
`
`Asn Asn Val
`
`Val Ala
`
`300
`
`Gln
`
`Pro Gln
`
`305
`
`<210>
`
`22
`
`<211>
`
`1314
`
`<212>
`
`<213>
`
`DNA
`
`Mus
`
`sp.
`
`<400> 22
`
`tttcctgtgt
`
`agactgttct
`
`cccgggcact
`
`accgtagcaa
`
`tggtgcctgt
`
`cctgctgtcc
`
`ctgcctctcc
`
`ttctgggtcc
`
`tgcagtcttt
`
`caggagactg
`
`ggtcttatta
`
`tctgaccttt
`
`ctctacaccg
`
`ggttgtccag
`
`acccagcaaa
`
`ggttttccga
`
`ggtttcaagc
`
`cactgcattt
`
`ctcaatgacc
`
`aggccttctt
`
`ccactacaac
`
`agcaacagcg
`
`QQGGQQCGQG
`
`QCCtQtQQQG
`
`ccttggagcc
`
`GQQtQQGGQQ
`
`aatggaggac
`
`tQQQGQGGQQ
`
`aaagccagct
`
`tcagagggcc
`
`0999099090
`
`tcttccttgt
`
`gaccctgaaa
`
`gacatcatgg
`
`actattacaa
`
`ggacactaca
`
`gggtctcaca
`
`cctttcaggg
`
`aatgtttggt
`
`tgcgagatca
`
`caaataacag
`
`aagtagtgga
`
`60
`
`120
`
`180
`
`240
`
`300
`
`360
`
`420
`
`
`
`gctgtctgga
`
`ggtatgccta
`
`cgacggagag
`
`gatttcatcg
`
`aattcaacaa
`
`agaaatccca
`
`gcttggatcc
`
`ccttagaccc
`
`agcagctgca
`
`aacaccaagc
`
`taaagtggga
`
`agcagaaaag
`
`gtctacgtgc
`
`agcgagccaa
`
`ggcataccta
`
`QGQQGQQGQt
`
`gtcctgaaat
`
`QCtQGGQGQQ
`
`tacctgaact
`
`acagtcgatc
`
`tcacctggac
`
`cgaatagatc
`
`ctcccactgt
`
`gacaatcacc
`
`480
`
`540
`
`600
`
`660
`
`agccgtgtga
`
`tcccaggagg
`
`aaacagaata
`
`ttcaaatgcc
`
`tggcctatgg
`
`cttctaccca
`
`720
`
`caaagaatta
`
`gtctgcactg
`
`gaacaaggcc
`
`aacaagaagc
`
`tagcatttga
`
`accagaaaga
`
`ggtgtttttc
`
`ccaatggaaa
`
`tggcacttac
`
`ctctcctggg
`
`cagaggtgga
`
`agtctcccca
`
`accccttctt
`
`ggttttccca
`
`atctctctcg
`
`780
`
`840
`
`900
`
`caggacatag
`
`ctgcctcata
`
`gatcacaggg
`
`QtQCGQtQQQ
`
`ataggacaag
`
`aaaagtaaag
`
`gatgaaaaca
`
`atgttgtagc
`
`tcagcctcag
`
`taagttaccc
`
`tctctgcctg
`
`acatgagaga
`
`ggtgaacttc
`
`agaagtcaat
`
`gtcatcaaca
`
`aggtcttcca
`
`tgggccactg
`
`tacaacagcc
`
`agcaagaatc
`
`caaggaagag
`
`gcatgggcac
`
`agaagacttg
`
`aatgccacag
`
`actgagttca
`
`ctctcaatgt
`
`cagatcaatc
`
`gccttgcctt
`
`gtaaacctcc
`
`tccttgatta
`
`atctgtcaac
`
`cctcacaatt
`
`gccctcatgc
`
`ctagaacagc
`
`960
`
`1020
`
`1080
`
`1140
`
`1200
`
`acagaaagga
`
`aggcatttta
`
`aactcagaga
`
`tgctagagaa
`
`gtgtgagttg
`
`attttatcat
`
`1260
`
`gtattctgcc
`
`cccacatact
`
`tgattcaatt
`
`gtgaacatct
`
`tcatattcac
`
`tcaa
`
`1314
`
`
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