`Atty. Docket No.: GWLG-017US-CIP
`Response to Final Office Action
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`(Currently Amended) The method of claim 13, admaflybeenrprwfiig—deteetmg—the
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`presenee—and wherein the level of circulating BDNF is determined in the sample—byL
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`(Currently Amended) The method of claim 15, admaflybeernprwfiig—deteetmg—the
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`presenee—and wherein the level of ZAG is determined in the sample—byheentaeti-ng—the
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`(Previously presented) A method of determining levels of circulating BDNF and CA-125
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`15.
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`l6.
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`17.
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`in a mammal comprising:
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`detecting the presence of BDNF and CA-125 in a plasma sample from the mammal
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`by contacting the sample with an anti-BDNF antibody and an anti-CA-125 antibody;
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`detecting binding between the anti-BDNF antibody and BDNF and between the
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`anti-CA-125 antibody and CA-125 in the sample; and
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`determining the circulating levels of BDNF and CA-125 in the mammal based on
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`the amount of antibody binding.
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