`
`Sequence Listing was accepted.
`
`
`
`
`If you need help call the Patent ?1ectronic Qusiness Center at
`
`217—9197 (toll free).
`
`(866)
`
`Reviewer: Anjum, Durreshwar
`
`Timestamp:
`
`[year=2017; month=ll; day=16; hr=12; min=33;
`
`sec=46; ms=808;
`
`]
`
`

`

`Validated By CRFValidator v 1,0,5
`
`Application No:
`
`1 5632497
`
`Version No:
`
`1_0
`
`Input Set:
`
`Output Set:
`
`Started:
`
`2017—11—13 20:34:52.701
`
`Finished:
`
`2017—11—13 20:34:53.086
`
`Elapsed:
`
`0 hr(s)
`
`0 min(s)
`
`0 sec(s) 385 ms
`
`Total Warnings:
`
`Total Errors:
`
`NO.
`
`of SquDs Defined:
`
`Actual SquD Count:
`
`10
`
`0
`
`22
`
`22
`
`Error code
`
`Error Description
`
`Undefined orga
`
`
`1ism found 'n <2l3>
`'n SWQ ID (3)
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`402
`
`402
`
`402
`
`402
`
`213
`
`213
`
`213
`
`213
`
`402
`
`402
`
`
`
`
`
`Undefined orga
`
`Undefined orga
`
`Undefined orga
`
`Art'f'c'a or
`
`
`Art'f'c'a or
`
`
`
`
`
`Art'f'c'a or
`
`Art'f'c'a or
`
`Undefined orga
`
`Undefined orga
`
`
`1ism found 'n <2l3>
`'n SWQ ID (4)
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1ism found 'n <2l3>
`'n SWQ ID (6)
`
`
`1ism found 'n <2l3>
`'n SWQ ID (7)
`
`
`Jnknown found 'n <2l3>
`'1 SWQ ID (9)
`
`
`Jnknown found 'n <2l3>
`'1 SWQ ID (10)
`
`Jnknown found 'n <2l3>
`
`'1 SWQ ID (11)
`
`
`Jnknown found 'n <2l3>
`'1 SWQ ID (12)
`
`1ism found 'n <2l3>
`
`
`
`
`
`
`1ism found 'n <2l3>
`'n SWQ ID (22)
`
`'n SWQ ID (21)
`
`
`
`

`

`
`
` O]
`*QUPNC ~ LISLING
`
`A "10>
`
`McMaster University
`
`<130>
`
`<"4O /
`<141>
`
`<120>
`
` A "70>
`
`Method of Diagnosing and Monitoring Inflammatory Disease
`Progression
`
`GWLG—017US—CI
`
`P
`
`US 15/632,497
`2017—06—26
`
`22
`
`PatentIn version 3.3
`
`1 7
`
`2
`PRT
`
`Homo sapiens
`
`<210>
`<211>
`<212>
`<213>
`
`<400>
`
`Ala
`
`Val
`
`Asp Met Ser
`
`Gly
`
`Thr
`
`Val Thr
`10
`
`Val Leu
`
`Glu
`
`Pro
`
`Val
`15
`
`Val
`
`Ser
`
`Lys Gly Gln
`20
`
`Leu
`
`Gln
`
`Tyr Phe
`25
`
`Glu
`
`Thr
`
`Cys
`
`Asn
`
`Lys
`30
`
`Pro
`
`Met
`
`Gly Tyr Thr
`35
`
`Glu
`
`Gly
`40
`
`Cys Arg
`
`Ile
`
`45
`
`Arg
`
`His
`
`Trp
`
`Ser Gln Cys
`
`Arg
`
`Thr
`
`Gln Ser
`
`Thr
`(II (II
`
`Val
`60
`
`Arg
`
`Ala
`
`Leu
`
`Thr
`
`Met
`65
`
`Asp
`
`Ser Lys Lys
`
`Ile
`
`Gly
`
`Arg
`70
`
`2 7
`
`O
`PRT
`
`Homo sapiens
`
`<2lO>
`<211>
`<212>
`<213>
`
`<400>
`
`Ser Ile Thr Leu Ser Cys
`1
`5
`
`Ser Val Ala Gly Asp Pro Val Pro Asn Met
`10
`15
`
`Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met Asn Glu Thr Ser
`20
`25
`3O
`
`

`

`His Thr
`
`Gln Gly Ser
`35
`
`Leu Arg Ile Thr Asn Ile Ser Ser Asp Asp Ser
`40
`45
`
`Gln Ile Ser
`
`Gly Lys
`50
`
`Cys Val Ala Glu Asn Leu Val Gly Glu Asp Gln
`55
`6O
`
`Asp Ser
`65
`
`Val Asn Leu
`
`Thr
`70
`
`<210>
`<211>
`<212>
`<213>
`
`<400>
`
`71
`PRT
`
`Mus sp.
`
`Lys Ser
`
`Val Thr Leu
`
`Ser Cys
`
`Ser
`
`Val
`
`Gly
`10
`
`Gly
`
`Asp Pro
`
`Leu
`
`Pro Thr
`15
`
`Leu Tyr
`
`Trp Asp Val
`20
`
`Gly Asn
`
`Leu
`
`Val
`25
`
`Lys
`
`His Met
`
`Glu Thr
`
`Asn
`30
`
`Ser His
`
`Thr Gln Gly
`35
`
`Ser Leu
`
`Arg
`40
`
`Ile
`
`Thr
`
`Asn
`
`Ile Ser
`45
`
`Ser
`
`Asp Asp
`
`Ser Gly
`50
`
`Lys Gln Ile
`
`Ser Cys
`55
`
`Val
`
`Ala
`
`Glu
`
`Asn
`
`Leu Val
`60
`
`Glu Asp
`
`Gln Asp
`65
`
`Ser Val Asn
`
`Leu Thr
`70
`
`4 7
`
`O
`PRT
`
`Rattus sp.
`
`<2lO>
`<211>
`<212>
`<2l3>
`
`<400>
`
`Ser Val Thr Ile Ser Cys Ser
`1
`5
`
`Val
`
`Gly Gly Asp Pro Leu Pro
`10
`
`Tyr Trp Asp Val Gly Asn Leu Val
`20
`
`Ser Lys His Met Asn Glu
`25
`30
`
`"hr Leu
`
` "hr Ser
`
`His Thr Gln Gly Ser Leu Arg Ile
`35
`40
`
`Thr Asn Ile Ser Ser Asp
`45
`
`Asp Ser
`
`

`

`Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val Gly Glu Asp Gln
`50
`55
`6O
`
`Asp Ser Val Asn Leu Thr
`65
`70
`
`<210>
`<211>
`<212>
`
`5
`219
`DNA
`
`<213>
`
`Homo sapiens
`
`<400>
`
`5
`
`tgcagtggac atgtcgggcg
`
`ggacggtcac
`
`agtccttgaa aaggtccctg tatcaaaagg
`
`ccaactgaag caatacttct
`
`acgagaccaa
`
`gtgcaatccc atgggttaca caaaagaagg
`
`ctgcaggggc atagacaaaa
`
`ggcattggaa
`
`ctcccagtgc cgaactaccc agtcgtacgt
`
`gcgggccctt accatggata
`
`gcaaaaagag
`
`aattggctg
`
`<210>
`<211>
`<212>
`
`6
`216
`DNA
`
`<213> Mus Sp.
`
`<400>
`
`6
`
`tgcagtggac atgtctggcg
`
`ggacggtcac
`
`agtcctagag aaagtcccgg tatccaaagg
`
`ccaactgaag cagtatttct
`
`acgagaccaa
`
`gtgtaatccc atgggttaca ccaaggaagg
`
`ctgcaggggc atagacaaaa
`
`ggcactggaa
`
`ctcgcaatgc cgaactaccc aatcgtatgt
`
`tcgggccctt actatggata
`
`gcaaaaagag
`
`aattgg
`
`<210>
`<211>
`<212>
`<2l3>
`
`7
`219
`DNA
`
`Rattus Sp.
`
`<400>
`
`7
`
`tgcagtggac
`
`atgtccggtg
`
`ggacggtcac
`
`agtcctggag aaagtcccgg tatcaaaagg
`
`ccaactgaag
`
`caatatttct
`
`acgagaccaa
`
`gtgtaatccc atgggttaca cgaaggaagg
`
`ctgcaggggc
`
`atagacaaaa
`
`ggcactggaa
`
`ctcgcaatgc cgaactaccc aatcgtatgt
`
`tcgggccctt
`
`actatggata
`
`gcaaaaagag
`
`aattggctg
`
`<210>
`<211>
`
`8
`210
`
`60
`
`120
`
`180
`
`219
`
`60
`
`120
`
`180
`
`216
`
`60
`
`120
`
`180
`
`219
`
`

`

`<212>
`
`DNA
`
`<213>
`
`Homo sapiens
`
`<400>
`
`8
`
`gtctatcaca ttatcctgta gtgtggcagg tgatccggtt cctaatatgt attgggatgt
`
`6O
`
`tggtaacctg gtttccaaac atatgaatga aacaagccac acacagggct ccttaaggat
`
`120
`
`aactaacatt tcatccgatg acagtgggaa gcagatctct tgtgtggcgg aaaatcttgt
`
`180
`
`aggagaagat caagattctg tcaacctcac
`
`210
`
`9
`<210>
`20
`<211>
`DNA
`<212>
`<213> Artificial
`
`<220>
`<223> Primer
`
`<400>
`
`9
`
`gagctgagcg tgtgtgacag
`
`10
`<210>
`20
`<211>
`DNA
`<212>
`<213> Artificial
`
`<220>
`<223> Primer
`
`<400>
`
`10
`
`cttatgaatc gccagccaat
`
`11
`<210>
`20
`<211>
`DNA
`<212>
`<2l3> Artificial
`
`<220>
`<223> Primer
`
`<400>
`
`ll
`
`caattgtggt ttgccatctg
`
`12
`<210>
`20
`<211>
`DNA
`<212>
`<2l3> Artificial
`
`<220>
`<223> Primer
`
`20
`
`20
`
`20
`
`

`

`<400>
`
`12
`
`tgcaaaatgc acagtgaggt
`
`<210>
`<211>
`<212>
`<213>
`
`13
`158
`PRT
`Homo
`
`<400>
`
`13
`
`sapiens
`
`Met
`
`Leu
`
`Leu
`
`Leu
`
`Leu
`
`Thr
`
`Leu
`
`Ala
`
`Leu
`
`Val
`
`Val
`10
`
`Val
`
`Gly
`15
`
`Pro
`
`Ala
`
`Met
`
`Ile
`
`Pro
`
`Gln
`
`Thr
`
`20
`
`Lys
`25
`
`Gln
`
`Leu
`
`Glu
`
`Pro
`
`Leu
`30
`
`Ala
`
`Pro
`
`Leu
`
`Arg
`
`Val
`
`His
`
`Ile
`
`35
`
`Thr
`40
`
`Ser
`
`Leu
`
`Leu
`
`Pro
`
`Pro
`
`Glu
`
`Thr
`45
`
`Glu
`
`Ile
`
`Val
`
`Leu
`
`Leu
`50
`
`His
`55
`
`Arg
`
`Glu
`
`Ser
`
`Val
`
`Glu
`
`Val
`
`Leu
`
`Gly
`
`Thr
`
`Glu
`
`Asn
`
`Pro
`75
`
`Phe
`
`Lys
`
`Ile
`80
`
`Lys
`65
`
`Glu
`70
`
`Asn
`
`Thr
`
`Val
`
`Ala
`85
`
`Asn
`
`Glu
`
`Ala
`
`Thr
`
`Leu
`
`Leu
`
`Thr
`
`90
`
`95
`
`Phe
`
`Leu
`
`Phe
`100
`
`Leu
`
`Leu
`
`Gln
`
`Thr
`
`Thr
`
`Thr
`
`Pro
`
`Gln
`
`Ser
`
`Ile
`110
`
`Met
`
`Met
`
`Cys
`115
`
`Gln
`
`Leu
`
`Ala
`
`Arg
`120
`
`Val
`
`Leu
`
`Val
`
`Glu
`
`Glu
`
`Ile
`
`125
`
`Met
`
`Gln
`130
`
`Phe
`
`Ile
`
`Arg
`
`Ala
`135
`
`Phe
`
`Arg
`
`Pro
`
`Leu
`
`Pro
`
`Arg
`
`His
`
`Leu
`
`140
`
`Leu
`
`Leu
`
`Leu
`
`Gln
`
`Met
`
`Glu
`
`Glu
`
`Arg
`
`Phe
`
`145
`
`<210>
`<2ll>
`<212>
`<213>
`
`14
`180
`PRT
`
`Homo sapiens
`
`<400>
`
`14
`
`

`

`Met
`
`Leu
`
`Leu
`
`Leu
`
`Leu
`
`Thr Leu
`
`Ala
`
`Leu
`
`Val
`
`Val
`10
`
`Val
`
`Gly
`15
`
`Pro
`
`Ala
`
`Met
`
`Ile
`
`Pro
`
`Gln Thr
`
`20
`
`Gln
`
`Leu
`
`Glu
`
`Leu
`
`Pro
`
`Lys
`25
`
`Leu
`
`Ala
`
`Gly
`35
`
`Thr
`
`Trp
`
`His
`
`Ser Met
`40
`
`Ala
`
`Met
`
`Ala
`
`Thr
`
`Asn
`
`Ile
`
`Asn
`45
`
`Leu
`
`Met
`
`Ala
`
`Thr
`
`Leu
`
`50
`
`Ala Pro
`55
`
`Leu
`
`Arg
`
`Val
`
`His
`60
`
`Ile
`
`Thr
`
`Ser
`
`Leu
`
`Leu
`65
`
`Pro
`
`Thr
`
`Pro
`
`Glu
`
`Asn Leu
`
`Glu
`
`Ile
`
`70
`
`Leu
`
`His
`
`Arg
`
`Val
`75
`
`Glu
`80
`
`Asn
`
`Asn
`
`Glu
`
`Thr
`
`Asn
`
`Glu
`
`Val
`85
`
`Val
`
`Leu
`90
`
`Gly
`
`Glu
`95
`
`Ile
`
`Asn Tyr
`
`Val
`
`Ala
`
`Asn
`
`Glu
`
`Thr
`
`Leu
`
`Ala
`110
`
`Pro
`
`Leu
`
`Phe
`100
`
`Thr
`115
`
`"05 __.eu
`
`120
`
`Phe
`
`Leu
`
`Gln
`
`Thr
`
`Leu
`125
`
`Thr
`
`Thr
`130
`
`Pro
`
`Ile
`
`Gln
`
`Met Met
`135
`
`Gln
`
`Leu
`140
`
`Ala
`
`Arg
`
`Val
`
`Leu
`
`Glu
`
`Val
`145
`
`Glu
`
`Ile
`150
`
`Met Gln
`
`Phe
`
`Arg
`
`Ala
`
`Phe
`
`Arg
`
`Ile
`155
`
`Pro
`
`160
`
`Leu
`
`Pro
`
`Arg
`
`His
`
`Leu
`165
`
`Trp
`
`Tyr Leu
`
`Leu
`
`Leu
`
`Gln
`
`Met
`
`Glu
`
`Glu
`175
`
`Pro
`
`Arg
`
`Phe
`180
`
`15
`180
`PRT
`Homo
`
`<2lO>
`<211>
`<212>
`<2l3>
`
`<400>
`
`sapiens
`
`Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val
`
`

`

`Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys
`20
`25
`30
`
`Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser
`35
`40
`45
`
`Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu
`50
`55
`6O
`
`Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu
`65
`70
`75
`80
`
`Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn
`85
`9O
`95
`
`Pro Lys Lys Phe Lys Ile Asn Tyr "hr Val Ala Asn Glu Ala Thr Leu
`100
`"O5
`110
`
`Leu Asp Thr Asp Tyr Asp Asn Phe oeu Phe Leu Cys Leu Gln Asp Thr
`115
`120
`125
`
`
`
`Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu
`130
`135
`140
`
`Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro
`145
`150
`155
`160
`
`Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu
`165
`170
`175
`
`Pro Cys Arg Phe
`180
`
`<210>
`<21l>
`<212>
`
`l6
`830
`DNA
`
`<213>
`
`Homo sapiens
`
`<400>
`
`l6
`
`agcatccctc tggctccaga gctcagagcc acccacagcc gcagccatgc tgtgcctcct
`
`6O
`
`gctcaccctg ggcgtggccc tggtctgtgg tgtcccggcc atggacatcc cccagaccaa
`
`120
`
`

`

`gcaggacctg
`
`gagctcccaa
`
`agttggcagg
`
`gacctggcac
`
`tccatggcca
`
`tggcgaccaa
`
`caacatctcc
`
`ctcatggcga
`
`cactgaaggc
`
`ccctctgagg
`
`gtccacatca
`
`cctcactgtt
`
`gcccaccccc
`
`gaggacaacc
`
`tggagatcgt
`
`tctgcacaga
`
`tgggagaaca
`
`acagctgtgt
`
`tgagaagaag
`
`gtccttggag
`
`agaagactga
`
`gaatccaaag
`
`aagttcaaga
`
`tcaactatac
`
`ggtggcgaac
`
`gaggccacgc
`
`tgctcgatac
`
`tgactacgac
`
`aatttcctgt
`
`ttctctgcct
`
`acaggacacc
`
`accaccccca
`
`tccagagcat
`
`gatgtgccag
`
`tacctggcca
`
`gagtcctggt
`
`ggaggacgat
`
`gagatcatgc
`
`agggattcat
`
`cagggctttc
`
`aggcccctgc
`
`ccaggcacct
`
`atggtacttg
`
`ctggacttga
`
`aacagatgga
`
`agagccgtgc
`
`cgtttctagc
`
`tcacctccgc
`
`thcaggaag
`
`accagactcc
`
`cacccttcca
`
`cacctccaga
`
`gcagtgggac
`
`ttcctcctgc
`
`cctttcaaag
`
`aataaccaca
`
`gctcagaaga
`
`cgatgacgtg
`
`gtcatctgtg
`
`tcgccatccc
`
`cttcctgctg
`
`cacacctgca
`
`ccacggccat
`
`ggggaggctg
`
`ctccctgggg
`
`gcagagtctc
`
`tggcagaggt
`
`tattaataaa
`
`CCCttggagC
`
`atgaaaaaaa
`
`aaaaaaaaaa
`
`<210>
`<211>
`<212>
`<213>
`
`17
`830
`DNA
`
`Homo sapiens
`
`<400>
`
`l7
`
`acccacagcc
`
`180
`
`240
`
`300
`
`420
`
`480
`
`540
`
`600
`
`660
`
`720
`
`780
`
`830
`
`60
`
`agcatccctc
`
`tggctccaga
`
`gctcagagcc
`
`gcagccatgc
`
`tgtgcctcct
`
`gctcaccctg
`
`ggcgtggccc
`
`tggtctgtgg
`
`tgtcccggcc
`
`atggacatcc
`
`cccagaccaa
`
`gcaggacctg
`
`gagctcccaa
`
`agttggcagg
`
`gacctggcac
`
`tccatggcca
`
`tggcgaccaa
`
`caacatctcc
`
`thatggcga
`
`cactgaaggc
`
`CCCtCtgagg
`
`gtccacatca
`
`cctcactgtt
`
`gcccaccccc
`
`gaggacaacc
`
`tggagatcgt
`
`tctgcacaga
`
`tgggagaaca
`
`acagctgtgt
`
`tgagaagaag
`
`gtccttggag
`
`agaagactga
`
`gaatccaaag
`
`aagttcaaga
`
`tcaactatac
`
`ggtggcgaac
`
`gaggccacgc
`
`tgctcgatac
`
`tgactacgac
`
`aatttcctgt
`
`ttctctgcct
`
`acaggacacc
`
`accaccccca
`
`tccagagcat
`
`gatgtgccag
`
`tacctggcca
`
`gagtcctggt
`
`ggaggacgat
`
`gagatcatgc
`
`agggattcat
`
`cagggctttc
`
`aggcccctgc
`
`ccaggcacct
`
`atggtacttg
`
`ctggacttga
`
`aacagatgga
`
`agagccgtgc
`
`cgtttctagc
`
`tcacctccgc
`
`ctccaggaag
`
`accagactcc
`
`cacccttcca
`
`cacctccaga
`
`gcagtgggac
`
`ttcctcctgc
`
`cctttcaaag
`
`aataaccaca
`
`gctcagaaga
`
`cgatgacgtg
`
`gtcatctgtg
`
`tcgccatccc
`
`cttcctgctg
`
`cacacctgca
`
`ccacggccat
`
`ggggaggctg
`
`ctccctgggg
`
`gcagagtctc
`
`120
`
`180
`
`240
`
`360
`
`420
`
`480
`
`540
`
`600
`
`660
`
`720
`
`780
`
`

`

`tggcagaggt tattaataaa cccttggagc atgaaaaaaa aaaaaaaaaa
`
`<210>
`<211>
`<212>
`<213>
`
`18
`859
`DNA
`Homo
`
`<400>
`
`18
`
`sapiens
`
`agcatccctc
`
`tggctccaga
`
`gctcagagcc
`
`acccacagcc
`
`gcagccatgc
`
`tgtgcctcct
`
`gotcaccctg
`
`ggcgtggccc
`
`tggtctgtgg
`
`tgtcccggcc
`
`atggacatcc
`
`cccagaccaa
`
`goaggacctg
`
`gagctcccaa
`
`agttggcagg
`
`gacctggcao
`
`tcoatggcca
`
`tggcgaccaa
`
`caacatctcc
`
`ctcatggcga
`
`cactgaaggc
`
`ccctctgagg
`
`gtccacatca
`
`cctcactgtt
`
`gcccaccccc
`
`gaggacaacc
`
`tggagatcgt
`
`tctgcacaga
`
`tgggagaaca
`
`acagctgtgt
`
`tgagaagaag
`
`gtccttggag
`
`agaagactga
`
`gaatccaaag
`
`aagttcaaga
`
`tcaactatac
`
`ggtggcgaac
`
`gaggccacgc
`
`tgctcgatac
`
`tgactacgac
`
`aatttcctgt
`
`ttctctgcct
`
`acaggacacc
`
`accaccccca
`
`tacctggcca
`
`gagtcctggt
`
`830
`
`60
`
`120
`
`180
`
`240
`
`300
`
`360
`
`420
`
`480
`
`540
`
`600
`
`660
`
`720
`
`780
`
`840
`
`859
`
`tccagagcat
`
`gatgtgccag
`
`ggaggacgat
`
`gagatcatgc
`
`agggattcat
`
`cagggctttc
`
`aggcccctgc
`
`coaggcacct
`
`atggtacttg
`
`ctggacttga
`
`aacagatgga
`
`agagccgtgc
`
`cgtttctagg
`
`tgagctcctg
`
`cctggtcctg
`
`cctcctggct
`
`cacctccgcc
`
`tccaggaaga
`
`ccagactccc
`
`acccttccac
`
`acctccagag
`
`cagtgggact
`
`tcctcctgco
`
`ctttcaaaga
`
`ataaccacag
`
`ctcagaagac
`
`gatgacgtgg
`
`tcatctgtgt
`
`cgccatcccc
`
`ttcctgctgc
`
`acacctgcac
`
`cacggccatg
`
`gggaggctgc
`
`tccctggggg
`
`cagagtctct
`
`ggcagaggtt
`
`attaataaac
`
`ccttggagca
`
`tgaaaaaaaa
`
`aaaaaaaaa
`
`<210>
`<211>
`<212>
`<213>
`
`19
`298
`PRT
`Homo
`
`<400>
`
`19
`
`sapiens
`
`Met Val Arg
`1
`
`Met Val
`(fl
`
`
`Pro Val L u L u S r L u L u L u L u L u Gly
`10
`15
`
`Pro Ala Val
`
`Pro Glu
`20
`
`Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr
`25
`3O
`
`Ile Tyr Thr
`35
`
`Gly Leu
`
`Ser Lys His Val Glu Asp Val Pro Ala Phe Gln
`40
`45
`
`

`

`Ala
`
`Leu
`
`Gly
`
`Ser
`
`Leu
`
`Asn
`
`50
`
`Asp
`55
`
`Leu
`
`Gln
`
`Phe Phe
`
`Asn Ser
`
`Arg
`60
`
`Arg
`
`65
`
`Gln
`
`Pro
`70
`
`Met
`
`Gly
`
`Leu
`
`Trp Arg
`75
`
`Gln
`
`Val
`
`Glu Gly
`
`Glu
`
`Trp
`
`Asp
`
`Ser
`
`Gln
`
`Leu
`
`Gln
`85
`
`Gln Lys
`90
`
`Ala
`
`Arg
`
`Glu Asp
`95
`
`Met
`80
`
`Ile
`
`Phe
`
`Met
`
`Glu
`
`Leu
`
`Thr
`100
`
`Ile
`
`Val
`105
`
`Glu Tyr
`
`Asn
`
`Asn
`
`Asp Ser
`110
`
`Gly
`
`His
`115
`
`Val
`
`Leu
`
`Gln
`
`Gly
`
`Arg
`120
`
`Phe
`
`Gly Cys
`
`Glu
`
`Glu Asn
`
`Asn
`
`Ile
`125
`
`Arg
`
`Ser
`
`Ser
`
`Ala
`
`Phe
`
`130
`
`Lys
`
`Trp
`135
`
`Gly
`
`Lys Asp
`
`140
`
`Glu
`
`Phe
`
`Asn
`
`Ile
`
`Pro
`
`Ala
`
`Trp Val
`
`Pro
`
`Phe
`
`Asp Pro
`
`Ile
`145
`
`Glu
`150
`
`Ala
`160
`
`Ala
`
`Gln
`
`Ile
`
`Thr
`
`Arg
`
`Ala
`
`Ala
`180
`
`sys
`
`"65 yr
`
`Gln
`
`Trp
`
`Glu
`
`Ala Glu
`170
`
`Pro
`
`Val
`
`Gln
`
`Tyr Val
`175
`
`Leu
`
`Glu
`
`Glu
`
`Glu
`185
`
`Cys Pro
`
`Ala
`
`Thr
`
`Leu Arg
`190
`
`Leu
`
`Ser
`
`Leu
`
`Asp Arg
`
`Gln
`
`Pro Pro
`
`Ser
`
`Ile
`200
`
`Val
`
`Val
`210
`
`Val
`
`Thr
`
`His
`
`Ala
`
`Pro
`
`Gly Glu
`
`Gln
`215
`
`Lys
`220
`
`Lys Leu
`
`Leu
`
`Ala
`
`Cys
`225
`
`Phe
`230
`
`Pro
`
`235
`
`Val
`
`His Trp
`
`Thr
`240
`
`Arg
`
`Ala
`
`Gly
`
`Glu
`
`Val
`245
`
`Gln
`
`Glu
`
`Pro
`
`Glu
`
`Leu Arg
`250
`
`Gly
`
`Val Leu
`255
`
`His
`
`Asn
`
`Gly
`
`Asn
`
`Gly
`260
`
`Thr
`
`Gln
`
`Ser
`
`Trp
`265
`
`Val Val
`
`Val
`
`Ala
`
`Val Pro
`270
`
`Pro
`
`

`

`Gln Asp Thr
`275
`
`Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala
`280
`285
`
`Gln Pro Leu
`290
`
`Val Val Pro Trp Glu Ala Ser
`295
`
`<210>
`<21l>
`<212>
`<213>
`
`20
`1278
`DNA
`Homo
`
`<400>
`
`20
`
`sapiens
`
`ccattggcct
`
`gtagattcac
`
`ctcccctggg
`
`cagggcccca
`
`ggacccagga
`
`taatatctgt
`
`gcctcctgcc
`
`cagaaccctc
`
`caagcagaca
`
`caatggtaag
`
`aatggtgcct
`
`gtcctgctgt
`
`thtgctgct
`
`gcttctgggt
`
`cctgctgtcc
`
`cccaggagaa
`
`ccaagatggt
`
`Cgttactctc
`
`tgacctatat
`
`ctacactggg
`
`ctgtccaagc
`
`atgttgaaga
`
`cgtccccgcg
`
`tttcaggccc
`
`ttggctcact
`
`caatgacctc
`
`cagttcttta
`
`gatacaacag
`
`taaagacagg
`
`aagtctcagc
`
`ccatgggact
`
`Ctggagacag
`
`gtggaaggaa
`
`tggaggattg
`
`gaagcaggac
`
`agccaacttc
`
`agaaggccag
`
`ggaggacatc
`
`tttatggaga
`
`ccctgaaaga
`
`catcgtggag
`
`tattacaacg
`
`acagtaacgg
`
`gtctcacgta
`
`ttgcagggaa
`
`ggtttggttg
`
`tgagatcgag
`
`aataacagaa
`
`gcagcggagc
`
`attctggaaa
`
`tattactatg
`
`atggaaagga
`
`ctacattgaa
`
`ttcaacaaag
`
`ctgggtcccc
`
`ttcgacccag
`
`cagcccagat
`
`aaccaagcag
`
`aagtgggagg
`
`60
`
`120
`
`180
`
`240
`
`300
`
`360
`
`420
`
`480
`
`540
`
`600
`
`aaatcccagc
`
`cagaaccagt
`
`ctacgtgcag
`
`cgggccaagg
`
`cttacctgga
`
`ggaggagtgc
`
`cctgcgactc
`
`tgcggaaata
`
`cctgaaatac
`
`agcaaaaata
`
`tcctggaccg
`
`gcaagatcct
`
`CCCtCtgtgg
`
`tggtcaccag
`
`ccaccaggcc
`
`ccaggagaaa
`
`agaagaaact
`
`gaagtgcctg
`
`gcctacgact
`
`tctacccagg
`
`gaaaattgat
`
`gtgcactgga
`
`ctcgggccgg
`
`cgaggtgcag
`
`gagcctgagt
`
`tacggggaga
`
`tgttcttcac
`
`aatggaaatg
`
`gcacttacca
`
`gtcctgggtg
`
`gtggtggcag
`
`tgcccccgca
`
`ggacacagcc
`
`ccctactcct
`
`gccacgtgca
`
`gcacagcagc
`
`ctggcccagc
`
`ccctcgtggt
`
`gccctgggag
`
`gccagctagg
`
`aagcaagggt
`
`tggaggcaat
`
`gtgggatctc
`
`agacccagta
`
`gctgcccttc
`
`ctgcctgatg
`
`tgggagctga
`
`accacagaaa
`
`tcacagtcaa
`
`tggatccaca
`
`aggcctgagg
`
`agcagtgtgg
`
`ggggacagac
`
`aggaggtgga
`
`tttggagacc
`
`gaagactggg
`
`atgcctgtct
`
`tgagtagact
`
`tggacccaaa
`
`aaatcatctc
`
`accttgagcc
`
`cacccccacc
`
`ccattgtcta
`
`atctgtagaa
`
`gctaataaat
`
`aatcatccct
`
`ccttgcctag
`
`660
`
`720
`
`780
`
`840
`
`900
`
`960
`
`1020
`
`1080
`
`1140
`
`1200
`
`1260
`
`

`

`cataaaaaaa aaaaaaaa
`
`1278
`
`<210>
`<211>
`<212>
`
`21
`307
`PRT
`
`<213> Mus Sp.
`
`<400>
`
`21
`
`Met Val Pro Val Leu Leu Ser Leu Pro L
`
`