`Atty. Docket No.: GWLG-017US-CIP
`Response to Final Off1ce Action
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`“The background art does not
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`teach or
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`suggest markers
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`for
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`endometriosis that are sufficiently sensitive and/0r accurate, alone or in
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`combination.”
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`(Cohen el al., [0014], emphasis added.)
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`Thus, Applicant respectfully submits that Cohen el al., in View of Telimaa el 61]., fails to
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`teach the use of glycodelin as an effective biomarker for diagnosis of endometriosis. Furthermore,
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`Cohen el a]. does not teach the use of glycodelin in combination with one or more of BDNF, ZAG
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`and CA125 to diagnose endometriosis as claimed.
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`In fact, Cohen el al.
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`teaches away from
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`combining glycodelin with these other biomarkers.
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`The claimed method of diagnosing and treating endometriosis in a mammal including the
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`step of detecting the circulating levels of glycodelin and one or more of BDNF ZAG and CA125
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`advantageously exhibits a high level of specificity (e. g, greater than 70%) with respect to the
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`diagnosis of endometriosis in comparison to the low sensitivity described by Cohen el al.
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`Thus, claim 1 and the claims dependent thereon are believed to be both novel and
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`nonobvious in View of Cohen el al, and thus in compliance with 35 USC §102 and §103.
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`With regard to claims 8-12, the Examiner alleges that in View of art cited with respect to
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`the biomarkers (Cohen el al., Browne el al., Ward el al. and Signorile el 61].), and the Ahern
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`reference, it would have been obvious for one of skill in the art to compile the components of the
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`claimed kit. Applicant disagrees.
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`Amended claim 8 defines a kit comprising a glycodelin-specific reactant, and one or more
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`of a ZAG-specific reactant, a BDNF-specific reactant and a CA-lZS-specific reactant for use in a
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`method to diagnose endometriosis in a mammal.
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`10
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