`Atty. Docket No.: GWLG-017US-CIP
`Response to Non-Final Office Action
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`AMENDMENT TO THE SPECIFICATION
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`Please amend [0023] of the Specification as follows:
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`[0001] Figure 11 illustrates circulating concentrations of ZAG, glycodelin, BDNF, and
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`CA-125 between untreated cases (n=35-60) and controls (n=12-26) with ROC curves.
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`Circulating glycodelin (A) was significantly elevated (p=0.04l) in untreated cases
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`compared to controls. Circulating ZAG (B) tended to be elevated (p=0.086) in untreated
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`cases compared to controls. Circulating BDNF (C) was significantly higher (p=0.0008) in
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`untreated cases compared to controls while circulating concentrations of CA125 (D) did
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`not reach statistical significance (p=0.626). Glycodelin, ZAG, BDNF, and CA-125
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`produced ROC curves with an AUC of 0.70 (p=0.040), 0.66 (p=0.085), 0.73 (p<0.001),
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`and 0.47 (p=0.622), respectively. Statistically significant differences are denoted by an
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`asterisk (*) above the graph (* p<0.05; *** p<0.001). Sensitivity vs specificity plots are
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`provided in E). Whiskers on the box plots represent the 5th and 95th percentiles, while the
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`lower limit of the box lower quartile and the upper limit is the upper quartile. The line
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`within the box is the median of the data. Normally distributed data are portrayed as an
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`aligned dot plot with error bars representing standard deviation from the mean;
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`EDC_LAW\ 1826206\1
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`2
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