Filed Dec. 17, 2012

Serial No. 85804016

Registered Sept. 15, 2015

Registration No. 4,813,223

Class Industrial chemicals; active chemical ingredients for use in the manufacture of chemotherapeutic medicines; active chemical ingredients for use in the manufacture of medicines for treating a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas, breast and ovarian cancer, gastric cancer, lung cancer and lymphomas, acute myeloid leukemia, bladder cancer, metastatic breast cancer, metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoblastic leukaemia, breast cancer and non-small cell lung cancer, ovarian cancer and lung cancer, colon cancer, in particular, in combination with other chemotherapy, hairy cell leukemia (HCL) and multiple sclerosis, hematological malignancies, T-cell acute lymphoblastic leukemia, relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed, acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML), myelodysplastic syndromes, a class of conditions where certain blood cells are dysfunctional, and for acute myeloid leukemia (AML), immunosuppressant to prevent rejection in organ transplantation, it is especially useful in kidney transplants, to prevent rejection of organ transplants and treatment of renal cell cancer and other tumors, aggressive metastatic or locally advanced breast cancer, multiple myeloma, hematological disorders known as myelodysplastic syndromes (MDS), chronic lymphocytic leukemia, lymphomas and sarcoma, hormone-regractory prostate cancer, lymphoma and multiple myeloma, diseases of the immunological system, namely, auto-immune diseases, and prevention of organ rejection after transplantation; chemical preparations for use as intermediates for manufacture of finished active pharmaceutical ingredients for treating a wide range of cancers, diseases of the immunological system, namely, auto-immune diseases, and prevention of organ rejection after transplantation; 001; 005; 006; 010; 026; 046; 006; 018; 044; 046; 051; 052; 100; 101; 102; 100; 101; 100; 101