Name:
`Date of Birth:
`Place of Birth:
`Citizenship:
`Education:
`1965-1969
`
`1969-1973
`
`
`Positions held:
`1969-1973
`
`1974-1975
`
`1976-1978
`
`1979-1982
`1982-1986
`1986-2019
`
`Honors:
`
`2019-present
`
`
`Professional Activities:
`1980-2011
`1988-1994
`1994-2014
`1987-1992
`1991
`1992-2000
`1994-1998
`1994-1999
`2005-2015
`
`C U R R I C U L U M V I T A E
`
`John Kenneth Rose
`July 21, 1947
`Northampton, Massachusetts
`U.S.
`
`Brandeis University, Waltham, Massachusetts.
`B.A. in Biology
`Stanford University, Stanford, California
`Ph.D. Biology and Biochemical Genetics
`
`Predoctoral trainee of the U.S. Public Health Service
`with Dr. Charles Yanofsky, Stanford University
`Postdoctoral Fellow, Massachusetts Institute of Technology in
`the laboratories of Drs. Harvey Lodish and David Baltimore
`Research Associate, Massachusetts Institute of Technology, with
`Dr. David Baltimore
`Assistant Professor, The Salk Institute
`Associate Professor, The Salk Institute
`Professor of Pathology and Cell Biology
`Yale University School of Medicine
`Emeritus Professor of Pathology, Senior Research Scientist
`Yale University School of Medicine
`
`Editorial Board Member, Journal of Virology
`Editor of Virology for negative-strand RNA viruses
`Editorial Board Member,Virology
`Director of Graduate Studies in Experimental Pathology
`Co-chairman, Gordon Conference on Animal Cells and Viruses
`Director, Yale Medical School HIV research facility
`Member, NIH ARR-1 AIDS Study Section
`Co-director, Yale Graduate Program in Microbiology
`Director, Program in Virology and Vaccine Development, Yale
`University
`Two National Institutes of Health MERIT awards
`
`Page 1 of 17
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`KELONIA EXHIBIT 1003
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`Research Interests: Structure and function of viral glycoproteins. Vaccine development
`employing vectors based on recombinant RNA viruses. Specific targeting of viral
`vectors. Assembly of enveloped viruses.
`
`
`
`Publications
`1. Rose, J.K., Mosteller, R.D. & Yanofsky, C. 1970. Tryptophan messenger RNA
`elongation rates and steady state levels of tryptophan operon enzymes under
`various growth conditions. J. Mol. Biol. 51:541-550.
`2. Mosteller, R.D., Rose, J.K. & Yanofsky, C. 1970. Transcription initiation and
`degradation of trp mRNA. Cold Spring Harbor Symp. Quant. Biol. 35:461-466.
`3. Rose, J.K. & Yanofsky, C. 1971. Transcription of the operator proximal and distal
`ends of the tryptophan operon: evidence that trp E and trp A and the delimiting
`structural genes. J. Bacteriol. 108:615-618.
`4. Rose, J.K. & Yanofsky, C. 1972. Metabolic regulation of the tryptophan operon of
`Escherichia coli: Repressor-independent regulation of transcription initiation fre-
`quency. J. Mol. Biol. 69:103-118.
`5. Rose, J.K., Squires, C.L., Yanofsky, C., Yang, H.-L. & Zubay, G. 1973. Regulation of
`in vitro transcription of the tryptophan operon by purified RNA polymerase in the
`presence of partially purified repressor and tryptophan. Nature New Biol. 245:133-
`137.
`6. Squires, C.L., Rose, J.K., Yanofsky, C., Yang, H.-L. & Zubay, G. 1973. Tryptophanyl-
`tRNA and tryptophanyl-tRNA synthetase are not required for in vitro repression of
`the tryptophan operon. Nature New Biol. 245:131-133.
`7. Rose, J.K. & Yanofsky, C. 1974. Interaction of the operator of the tryptophan operon
`with repressor. Proc. Natl. Acad. Sci. USA 71: 3134-3138.
`8. Rose, J.K. & Knipe, D. 1975. Nucleotide sequence complexities, molecular weights
`and poly(A) content of the vesicular stomatitis virus mRNA species. J. Virol. 15:994-
`1003.
`9. Knipe, D., Rose, J.K. & Lodish, H.F. 1975. Translation of individual species of vesic-
`ular stomatitis viral mRNA. J. Virol. 15:1004-1011.
`10. Rose, J.K. 1975. Heterogeneous 5'-terminal structures occur on vesicular stomatitis
`virus mRNAs. J. Biol. Chem. 250:8098-8104.
`11. Hewlett, M.J., Rose, J.K. & Baltimore, D. 1976. 5'-terminal structure of poliovirus
`polyribosomal RNA is pUp. Proc. Natl. Acad. Sci. USA 73:327-330.
`12. Rose, J.K. & Lodish. H.F. 1976. Translation in vitro of vesicular stomatitis virus
`mRNA lacking 5'-terminal 7-methylguanosine. Nature 262:32-37.
`13. Rose, J.K., Hasletine, W.A. & Baltimore, D. 1976. The 5' terminus of Moloney
`murine leukemia virus 35S RNA is m7G5'ppp5'GmpCp. J. Virol. 20:324-329.
`
`Page 2 of 17
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`14. Lodish, H.F. & Rose, J.K. 1977. Relative importance of 7-methylguanosine in ribo-
`some binding and translation of vesicular stomatitis virus mRNA in wheat germ
`and reticulocyte cell-free systems. J. Biol. Chem. 252:1181-1188.
`15. Rose, J.K., Lodish, H.F. & Brock, M.L. 1977. Giant heterogeneous poly(A) on vesic-
`ular stomatitis virus mRNA synthesized in vitro in the presence of S-adenosylhomo-
`cysteine. J. Virol. 21:683-693.
`16. Freeman, G.J., Rose, J.K., Clinton, G.M. & Huang, A.S. 1977. RNA synthesis of vesic-
`ular stomatitis virus VII. Complete separation of the messenger RNAs of vesicular
`stomatitis virus by duplex formation. J. Virol. 21:1094-1104.
`17. Rose, J.K. 1977. Nucleotide sequences of ribosome recognition sites in messenger
`RNAs of vesicular stomatitis virus. Proc. Natl. Acad. Sci. USA 74:3672-3676.
`18. Pettersson, R.F., Flanegan, J.B., Rose, J.K. & Baltimore, D. 1977. 5'-terminal nucleo-
`tide sequences of polio virus polyribosomal RNA and virion RNA are identical.
`Nature (London) 268:270-272.
`19. Rose, J.K. 1977. Ribosome recognition sites in vesicular stomatitis virus mRNA. In,
`Negative Strand Viruses and the Host Cell (B.W.J. Mahy & R.D. Barry, eds.),
`Academic Press, New York, pp. 47-61.
`20. Baltimore, D., Pettersson, R.F., Flanegan, J.B., Hewlett, M.J., Rose, J.K. & Ambros, V.
`1978. New structures in viral RNA: Non- covalent circles and covalently-linked
`protein. In, Perspectives in Virology (M. Pollard, ed.), pp. 110-115.
`21. Rose, J.K. 1978. Complete sequences of the ribosome recognition sites in vesicular
`stomatitis virus mRNAs: Recognition by the 40S and 80S complexes. Cell 14:345-
`353.
`22. Rose, J.K., Trachsel, H., Leong, K. & Baltimore, D. 1978. Inhibition of translation by
`poliovirus: Inactivation of a specific initiation factor. Proc. Natl. Acad. Sci. USA
`75:2732-2736.
`23. Rose, J.K. & Iverson, L. 1979. Nucleotide sequences from the 3'-ends of vesicular
`stomatitis virus mRNAs as determined from cloned DNA. J. Virol. 32:404-411.
`24. Rose, J.K. 1980. Ribosome recognition and translation of vesicular stomatitis virus
`messenger RNA. In, Rhabdoviruses (D.H.L. Bishop, ed.), CRC Press, Boca Raton,
`Florida, pp. 51-60.
`25. Trachsel, H., Sonnenberg, N., Shatkin, A.J., Rose, J.K., Leong, K., Bergmann, J.E.,
`Gordon, J. & Baltimore, D. 1980. Purification of a factor that restores translation of
`vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells.
`Proc. Natl. Acad. Sci. USA 77:770-774.
`26. Rose, J.K. 1980. Complete intergenic and flanking gene sequences from the genome
`of vesicular stomatitis virus. Cell 19:415-421.
`27. Rose, J.K., Welch, W.J., Sefton, B.M., Esch, F.S. & Ling, N.C. 1980. Vesicular stomati-
`tis virus glycoprotein is anchored in the viral membrane by a hydrophobic domain
`near the COOH-terminus. Proc. Natl. Acad. Sci. USA 77:3884-3888.
`
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`28. Rose, J.K., Welch, W.J., Sefton, B.M. & Iverson, L.E. 1980. Analysis of VSV glycopro-
`tein structure and genome structure using cloned DNA. In, Animal Virus Genetics
`(B.N. Fields, R. Jaenisch & C.F. Fox, eds.), Academic Press, New York.
`29. Iverson, L.E. & Rose, J.K. 1981. Localized attenuation and discontinuous synthesis
`during vesicular stomatitis virus transcription. Cell 23:477-484.
`30. Rose, J.K., Iverson, L.E., Gallione, C.J. & Greene, J.R. 1981. Vesicular stomatitis virus
`gene structure and transcription attenuation. In, Negative Strand Viruses (D.H.L.
`Bishop & R. Compans, eds.), Elsevier, North Holland, pp. 713-721.
`31. Rose, J.K. & Gallione, C.J. 1981. Nucleotide sequences of the mRNAs encoding the
`vesicular stomatitis virus G and M proteins determined from cDNA clones contain-
`ing the complete coding regions. J. Virol. 39:519-528.
`32. Gallione, C., Greene, J., Iverson, L. & Rose, J.K. 1981. Nucleotide sequences of the
`mRNAs encoding the vesicular stomatitis virus N and NS proteins. J. Virol. 39:529-
`535.
`33. Rose, J.K. & Shafferman, A. 1981. Conditional expression of the vesicular stomatitis
`virus glycoprotein gene in Escherichia coli. Proc. Natl. Acad. Sci. USA 78:6670-6674.
`34. Rose, J.K., Doolittle, R., Anilionis, A., Curtis, P., Wunner, W. 1982. Homology be-
`tween the glycoproteins of vesicular stomatitis virus and rabies virus. J. Virol.
`43:361-364.
`35. Rose, J.K. & Bergmann, J.E. 1982. Expression from cloned cDNA of cell-surface and
`secreted forms of the glycoprotein of vesicular stomatitis virus in eucaryotic cells.
`Cell 30:753-762.
`36. Iverson, L.E. & Rose, J.K. 1982. Sequential synthesis of 5'-proximal vesicular stoma-
`titis virus mRNA sequences. J. Virol. 44: 356-365.
`37. Gallione, C.J. & Rose, J.K. 1983. Nucleotide sequence of a cDNA clone encoding the
`entire glycoprotein from the New Jersey serotype of vesicular stomatitis virus. J.
`Virol. 46:162-169.
`38. Rose, J.K. & Bergmann, J.E. 1983. Altered cytoplasmic domains affect intracellular
`transport of the vesicular stomatitis virus glycoprotein. Cell 34:513-524.
`39. Florkiewicz, R.Z., Smith, A., Bergmann, J.E. & Rose, J.K. 1983. Isolation of stable
`mouse cell lines that express cell surface and secreted forms of the vesicular
`stomatitis virus glycoprotein. J. Cell Biol. 97:1381-1388.
`40. Rose, J.K., Adams, G.A. & Gallione, C.J. 1984. The presence of cysteine in the cyto-
`plasmic domain of the vesicular stomatitis virus glycoprotein is required for
`palmitate addition. Proc. Natl. Acad. Sci. USA. 81:2050-2054.
`41. Florkiewicz, R.Z. & Rose, J.K. 1984. A cell line expressing the vesicular stomatitis
`virus glycoprotein fuses at low pH. Science 225:721-723.
`42. Guan, J.-L. & Rose, J.K. 1984. Conversion of a secretory protein into a trans-
`membrane protein results in its transport to the Golgi complex but not to the cell
`surface. Cell 37:779-787.
`
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`43. Gallione, C.J. & Rose, J.K., 1985. A single amino acid substitution in a hydrophobic
`domain causes temperature-sensitive cell-surface transport of a mutant viral glyco-
`protein. J. Virol. 54:374-382.
`44. Moller, J.R., Rager-Zisman, B., Phuc-Cahn, Q., Schattner, A., Panush, D., Rose, J.K.
`& Bloom, B.R. 1985. NK cell recognition of target cells expressing different antigens
`of vesicular stomatitis virus. Proc. Natl. Acad. Sci. U.S.A. 82:2456-2459.
`45. Mackett, M., Yilma, T., Rose, J. & Moss, B., 1985. Vaccinia virus recombinants:
`expression of VSV genes and protective immunization of mice and cattle. Science
`277:433-435.
`46. Adams, G.A. & Rose, J.K. 1985. Incorporation of a charged amino acid into the
`membrane spanning domain blocks cell-surface transport but not membrane-
`anchoring of a viral glycoprotein. Mol. Cell Biol. 5:1442-1448.
`47. Rose, J., Adams, G., Guan, J.-L., Machamer, C. & Puddington, L. 1985. Redesigning
`transport signals in membrane and secretory proteins. (In, Protein Transport and
`Secretion, pp. 7-85; ed. Mary-Jane Gething). Cold Spring Harbor Laboratory Press,
`1985.
`48. Adams, G.A. & Rose, J.K. 1985. Structural requirements of a membrane spanning
`domain for protein anchoring and cell surface transport. Cell 41:1007-1015.
`49. Machamer, C.E., Florkiewicz, R.Z. & Rose, J.K. 1985. A single N-linked oligo-
`saccharide at either of the two normal sites is sufficient for transport of the vesicular
`stomatitis virus G protein to the cell surface. Mol. Cell Biol. 5:3074-3083.
`50. Guan, J.-L., Machamer, C.E. & Rose, J.K. 1985. Glycosylation allows cell-surface
`transport of an anchored secretory protein. Cell 42:489-496.
`51. Rose, J.K. & Schubert, M. 1987. Rhabdovirus Genomes and Their Products. In, The
`Viruses, (eds. R. Wagner & H. Frankel-Conrat) Plenum Press, pp. 129-159.
`52. Machamer, C.E., Guan, J.-L., Florkiewicz, R.Z. & Rose, J.K. 1986. Role of N-linked
`glycosylation in intracellular transport of transmembrane proteins. Microbiology
`(Wash. D.C.) 1986:292-296.
`53. Woodgett, C. & Rose, J.K. 1986. Amino-terminal mutation of the vesicular stomatitis
`virus glycoprotein does not affect its fusion activity. J. Virol. 59:486-489.
`54. Puddington, L., Machamer, C.E. & Rose, J.K. 1986. Cytoplasmic domains of cellular
`and viral integral membrane proteins substitute for the cytoplasmic domain of the
`vesicular stomatitis virus glycoprotein in transport to the plasma membrane. J. Cell
`Biol. 102:2147-2157.
`55. Puddington, L., Bevan, M.J., Rose, J.K. & Lefrançois, L. 1986. N protein is the pre-
`dominant antigen recognized by vesicular stomatitis virus-specific cytotoxic T
`Cells. J. Virol. 60: 708-717.
`56. Puddington, L., Woodgett, C. & Rose, J.K. 1987. Replacement of the cytoplasmic do-
`main alters sorting of a viral glycoprotein in polarized cells. Proc. Natl. Acad. Sci.,
`USA 84:2756-2760.
`
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`57. Scullion, B.F, Hou, Y., Puddington, L., Rose, J.K. & Jacobson, K. 1987. Effects of
`mutations in three domains of the vesicular stomatitis viral glycoprotein on its
`lateral diffusion in the plasma membrane. J. Cell Biol. 105:69-75.
`58. Rottier, P.J.M. & Rose, J.K. 1987. Coronavirus E1 glycoprotein expressed from
`cloned cDNA localizes in the Golgi region. J. Virol. 61:2042-2045.
`59. Rottier, P.J.M., Florkiewicz, R.Z., Shaw, A.S. & Rose, J.K. 1987. An internalized
`amino-terminal signal sequence retains full activity in vivo but not in vitro. J. Biol.
`Chem. 262:8889-8895.
`60. Machamer, C.E. & Rose, J.K. 1987. A specific transmembrane domain of a corona-
`virus E1 glycoprotein is required for its retention in the Golgi region. J. Cell Biol.
`105:1205-1214.
`61. Kupfer, A., Kronebusch, P.J., Rose, J.K. & Singer, S.J. 1987. A critical role for the
`polarization of membrane recycling in cell motility. Cell Motility and the
`Cytoskeleton. 8:182-189.
`62. Guan, J.-L., Çao, H. & Rose, J.K. 1988. Cell-surface expression of a membrane-an-
`chored form of the human chorionic gonadotropin alpha subunit. J. Biol. Chem.
`263:5306-5313.
`63. Fukuda, M., Guan, J.-L. & Rose, J.K. 1988. A membrane-anchored form but not the
`secretory form of human chorionic gonadotropin alpha chain acquires polylactos-
`aminoglycan. J. Biol. Chem. 263:5314-5318.
`64. Machamer, C.E. & Rose, J.K. 1988. Influence of new glycosylation sites on expres-
`sion of the vesicular stomatitis virus G protein at the plasma membrane. J. Biol.
`Chem. 263:5948-5954.
`65. Machamer, C.E. & Rose, J.K. 1988. Vesicular stomatitis virus G proteins with altered
`glycosylation sites display temperature-sensitive intracellular transport and are
`subject to aberrant intermolecular disulfide bonding. J. Biol. Chem. 263:5955-5960.
`66. Doms, R.W., Ruusala, A., Machamer, C., Helenius, J., Helenius, A. & Rose, J.K.
`1988. Differential effects of mutations in three domains on folding, quarternary
`structure, and intracellular transport of vesicular stomatitis virus G protein. J. Cell
`Biol. 107:89-99.
`67. Guan, J.-L., Ruusala, A., Çao, H. & Rose, J.K. 1988. Effects of altered cytoplasmic do-
`mains on transport of the vesicular stomatitis virus glycoprotein are transferable to
`other proteins. Mol. Cell Biol. 8:2869-2874.
`68. Shaw, A.S., Rottier, P.J.M. & Rose, J.K. 1988. Evidence for the loop model of signal
`sequence insertion into the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA
`85:7592-7596.
`69. Rose, J.K. & Doms, R.W. 1988. Regulation of protein export from the endoplasmic
`reticulum. Ann. Rev. Cell Biol. 4:257-288.
`70. Whitt, M., Chong, L. & Rose, J.K. 1989. Glycoprotein cytoplasmic domain sequences
`required for rescue of the VSV glycoprotein mutant. J. Virol. 63:3569-3578.
`
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`71. Pitta, A.M., Rose, J.K., & Machamer, C.E. A single amino acid substitution elimi-
`nates the stringent carbohydrate requirement for the intracellular transport of a
`viral glycoprotein. J. Virol. 63:3801-3809.
`72. Shaw, A., Amrein, K., Hammond, C., Stern, D.F., Sefton, B.M. & Rose, J.K. 1989. The
`lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glyco-
`protein through its unique amino-terminal domain. Cell 59:627-636.
`73. Brown, D.A., Crise, B., & Rose, J.K. 1989. Mechanism of membrane anchoring af-
`fects polarized expression of two proteins in MDCK cells. Science 245:1499-1501.
`74. Zagouras, P., & Rose, J.K. 1989. Carboxy-terminal SEKDEL sequences retard but do
`not retain two secretory proteins in the endoplasmic reticulum. J. Cell Biol.
`109:2633-2640.
`75. Crise, B., Ruusala, A., Zagouras, P., Shaw, A., & Rose, J.K. 1989. Oligomerization of
`glycolipid-anchored and soluble forms of the vesicular stomatitis virus
`glycoprotein. J. Virol. 63:5328-5333.
`76. Miettinen, H.M., Rose, J.K., & Mellman, I. 1989. Fc receptor isoforms exhibit distinct
`abilities for coated pit localization as a result of cytoplasmic domain heterogeneity.
`Cell 58:317-327.
`77. Shaw A.S., Chalupny J., Whitney J.A., Hammond C., Amrein K.E., Kavathas P.,
`Sefton B.A. & Rose J.K. 1990. Short related sequences in the cytoplasmic domains of
`CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine
`protein kinase. 1990. Mol. Cell Biol. 10:1853-1862.
`78. Machamer, C.E., Doms, R.W., Bole, D.G., Helenius, A. & Rose, J.K. 1990. Heavy
`chain binding protein recognizes incompletely disulfide-bonded forms of vesicular
`stomatitis virus G protein. J. Biol. Chem. 265:6879-6883.
`79. Machamer, C.E., Mentone, S.A., Rose, J.K., Farquhar, M.G. 1990. The E1
`glycoprotein of an avian coronavirus is targeted to the cis Golgi complex.
`Proc.Natl.Acad.Sci.USA 87:6944-6948.
`80. Buonocore, L., & Rose, J.K. 1990. Prevention of HIV-1 glycoprotein transport by
`soluble CD4 retained in the endoplasmic reticulum. Nature 345:625-628.
`81. Crise, B., Buonocore, L., & Rose, J.K. 1990. CD4 is retained in the endoplasmic
`reticulum by the HIV-1 glycoprotein precursor. J. Virol. 64:5585-5593.
`82. Whitt, M.A., Zagouras, P., Crise, B., & Rose, J.K. 1990. A fusion-defective mutant of
`the vesicular stomatitis virus glycoprotein. J. Virol. 64:4907-4913.
`83. Rose, J.K, Buonocore, L., & Whitt, M.A. 1991. A new cationic liposome reagent
`mediating nearly quantitative transfection of animal cells. BioTechniques 10:520-525
`84. Whitt, M.A., Buonocore, L., Rose, J.K., Ciccarone, V., Chytil, A., & Gebeyehu, G.
`1991. TransfectACETM reagent: Transient transfection frequencies >90%. FOCUS
`13:8-12.
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`85. Zagouras, P., Ruusala, A., & Rose, J.K. 1991. Dissociation and reassociation of
`oligomeric viral glycoprotein subunits in the endoplasmic reticulum. J. Virol.
`65:1976-1984.
`86. Whitt, M.A., Buonocore, L., Préhaud, C., & Rose, J.K. 1991. Membrane fusion
`activity, oligomerization, and assembly of the rabies virus glycoprotein. Virology
`185:681-689.
`87. Zhang, F., Crise, B., Su, B., Hou, Y., & Rose, J.K., Bothwell, A., Jacobson, K. 1991.
`Lateral diffusion of membrane-spanning and glycosylphosphatidylinositol-linked
`proteins: Toward establishing rules governing the lateral mobility of membrane
`proteins. J. Cell Biol. 115:75-84.
`88. Whitt, M.A., & Rose, J.K. 1991. Fatty acid acylation is not required for membrane
`fusion activity or glycoprotein assembly into VSV virions. Virology 185:875-878.
`89. Brown, D.A., & Rose, J.K. 1992. Sorting of GPI-anchored proteins to glycolipid-en-
`riched membrane subdomains during transport to the apical cell surface. Cell
`68:533-544.
`90. Miettinen, H.M., Matter, K., Hunziker, W., & Rose, J.K., Mellman, I. 1992. Fc
`receptor endocytosis is controlled by a cytoplasmic domain determinant that
`actively prevents coated pit localization. J. Cell Biol. 116:875-888.
`91. Crise B., & Rose, J.K. 1992. Human immunodeficiency virus type 1 glycoprotein
`precursor retains a CD4-p56lck complex in the endoplasmic reticulum. J. Virol.
`66:2296-2301.
`92. Zhang, Z., Crise, B., Su, B., Hou, Y., Rose, J.K., Bothwell, A., Jacobson, K. 1992. The
`lateral mobility of some membrane proteins is determined by their ectodomains.
`Biophys. J. 62:92-94.
`93. Crise, B., & Rose, J.K. 1992. Identification of palmitoylation sites on CD4, the HIV
`receptor. J. Biol. Chem. 267:13593-13597
`94. Locker, J.K., Rose, J.K., Horzinek, M.C., Rottier, P.J. 1992. Membrane assembly of
`the triple-spanning coronavirus M protein: Individual transmembrane domains
`show preferred orientation. J. Biol. Chem. 267:21911-21918.
`95. Owens R.J., & Rose, J.K. 1993. Cytoplasmic domain requirement for incorporation
`of a foreign envelope protein into vesicular stomatitis virus. J. Virol. 68:360-365
`96. Chong, L.D., & Rose, J.K. 1993. Membrane association of functional vesicular
`stomatitis virus matrix protein in vivo. J. Virol. 67:407-414.
`97. Buonocore, L., & Rose, J.K. 1993. Blockade of HIV-1 production in CD4+ T cells by
`an intracellular CD4 expressed under control of the viral long terminal repeat. Proc.
`Natl. Acad. Sci. USA 90:2695-2699.
`98. Doms, R.W., Lamb, R.A., Rose, J.K., & Helenius, A. 1993. Folding and assembly of
`viral membrane proteins. Virology 193:545-562.
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`99. Cattaneo, R., & Rose, J.K. 1993. Cell fusion by the envelope glycoproteins of
`persistent measles viruses which caused lethal human brain disease. J. Virol.
`67:1493-1502.
`100. Zagouras, P. & Rose, J.K. 1993. Dynamic equilibrium between vesicular stomatitis
`virus glycoprotein monomers and trimers in the Golgi and at the cell surface. J.
`Virol. 67:7533-7538.
`101. Chong, L.D., & Rose, J.K. 1994. Interaction of normal and mutant vesicular stoma-
`titis virus matrix proteins with the plasma membrane and nucleocapsids. J. Virol.
`68:441-447.
`102. Owens, R.J., Burke, C., & Rose, J.K. 1994. Mutations in the membrane-spanning do-
`main of the human immunodeficiency virus envelope glycoprotein that affect
`fusion activity. J. Virol. 67:570-574
`103. Turi, T.G., Webster, P., & Rose, J.K. Brefeldin A sensitivity and resistance in Schizo-
`saccharomyces pombe: Identification of multiple genes conferring resistance. 1994. J.
`Biol. Chem., 269:24229-24236.
`104. Rodgers, W.A., Crise, B.C., & Rose, J.K. 1994. Signals determining protein tyrosine
`kinase and GPI-anchored protein targeting to a glycolipid-enriched membrane
`fraction. Mol. Cell. Biol. 14:5384-5391
`105. Rolls, M.M,. Webster, P., Balba, N.H., & Rose, J.K. 1994. Novel infectious particles
`generated by expression of the vesicular stomatitis virus glycoprotein from a self-
`replicating RNA. Cell 79:497-506.
`106. Buonocore, L., Turi, T.G., Crise, B., & Rose, J.K. 1994. Stimulation of heterologous
`protein degradation by the Vpu protein of HIV-1 requires the transmembrane and
`cytoplasmic domains of CD4. Virology 204: 482-486.
`107. Lawson, N., Stillman, E.A., Whitt, M.A., & Rose, J.K. 1995. Recombinant vesicular
`stomatitis viruses from DNA. Proc.Natl.Acad.Sci. USA 92: 4477-4481.
`108. Stillman, E. A., Rose, J. K., and Whitt, M. A. (1995). Replication and amplification
`of novel vesicular stomatitis virus minigenomes encoding viral structural proteins.
`J. Virol. 69, 2946-53.
`109. Turi, T. G., and Rose, J. K. (1995). Characterization of a novel Schizosaccharomyces
`pombe multidrug resistance transporter conferring brefeldin A resistance. Biochem
`Biophys Res Commun 213, 410-8.
`110. Kretzschmar, E., Peluso, R., Schnell, M. J., Whitt, M. A., and Rose, J. K. (1996).
`Normal replication of vesicular stomatitis virus without C proteins. Virology 216,
`309-316.
`111. Wagner, R.R. and Rose, J.K. (1996) Rhabdoviridae and their replication. In
`Virology, (Eds. B.N. Fields and D.M. Knipe). Raven Press, New York.
`112. Rolls, M. M., Haglund, K., and Rose, J. K. (1996). Expression of additional genes in
`a vector derived from a minimal RNA virus. Virology 218, 406-411.
`113. Schnell, M. J., Buonocore, L., Whitt, M. A., and Rose, J. K. (1996). The minimal
`conserved transcription stop-start signal promotes stable expression of a foreign
`gene in vesicular stomatitis. J. Virol. 70, : 2318-2323.
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`114. Kretzschmar, E., Bui, M., and Rose, J.K. (1996) Membrane association of influenza
`virus matrix protein does not require specific hydrophobic domains or the viral
`glycoproteins. Virology 220 : 37-45.
`115. Schnell, M.J., Buonocore, L., Kretzschmar, E., Johnson, E., and Rose, J.K. (1996)
`Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are
`incorporated efficiently into virus particles. Proc. Natl. Acad. Sci. USA 93: 11359-
`11365.
`116. Degar, S., Johnson, E., Boritz, E., and Rose, J.K. 1996. Replication of primary HIV-1
`isolates is inhibited in PM1 cells expressing sCD4-KDEL. Virology 226:424-429.
`117. Rose, J.K. (1996) Positive strands to the rescue again: A segmented negative-strand
`RNA virus derived from cloned cDNAs. Proc. Natl. Acad. Sci. USA 94: 14998-
`15000.
`118. Johnson, J. E., Schnell, M. J., Buonocore, L., and Rose, J. K. (1997). Specific
`targeting to CD4+ Cells of recombinant vesicular stomatitis viruses encoding
`human immunodeficiency virus envelope proteins. J. Virol. 71, 5060-5068.
`119. Kretzschmar, E., Buonocore, L., Schnell, M. J., and Rose, J. K. (1997). High efficiency
`incorporation of functional influenza virus glycoproteins into recombinant
`vesicular stomatitis viruses. J. Virol. 216:3 09.
`120. Schnell, M. J., Johnson, J. E., Buonocore, L., and Rose, J. K. (1997). Control of HIV-1
`infection by a novel virus specifically targeted to HIV-1-infected cells. Cell. 90: 849-
`857.
`121. Schnell, M.J., Buonocore, L., Boritz, E., Ghosh, H.P., Chernish, R., and Rose, J.K.
`(1998). Requirement for a non-specific glycoprotein cytoplasmic domain sequence
`to drive efficient budding of vesicular stomatitis virus. EMBO J. 17:1289-1296.
`122. Roberts, A.J., Kretzschmar, E., Perkins, A.S., Forman, J, Price, R., Buonocore, L.,
`Kawaoka, Y., and Rose, J.K. (1998) Vaccination with a recombinant vesicular
`stomatitis virus expressing an influenza virus hemagglutinin provides complete
`protection from influenza virus challenge. J. Virol. 72: 4704-4711.
`123. Roberts, A., and Rose, J.K. (1998) Recovery of negative-strand RNA viruses
`fromplasmid DNAs: a positive approach revitalizes a negative field. Virology 247:1-
`6
`124. Johnson, J. E., Rodgers, W., and Rose, J. K. (1998). A plasma membrane localization
`signal in the HIV-1 envelope cytoplasmic domain prevents localization at sites of
`vesicular stomatitis virus budding and incorporation into VSV virions. Virology
`251: 244-252.
`125. Kim, S. K., Reed, D. S., Olson, S., Schnell, M. J., Rose, J. K., Morton, P. A., and
`Lefrancois, L. (1998). Generation Of Mucosal Cytotoxic T Cells Against Soluble
`Protein By Tissue-Specific Environmental and Costimulatory Signals. Proc Natl.
`Acad. of Sciences, U. S. A. 95, 10814-10819.
`126. Boritz, E., Gerlach, J., Johnson, J. E., and Rose, J. K. (1999). Replication-competent
`rhabdoviruses with human immunodeficiency virus type 1 coats and green
`fluorescent protein: entry by a pH-independent pathway. J Virol 73, 6937-45.
`
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`127. Kahn, J. S., Schnell, M. J., Buonocore, L., and Rose, J. K. (1999). Recombinant
`vesicular stomatitis virus expressing respiratory syncytial virus (RSV)
`glycoproteins: RSV fusion protein can mediate infection and cell fusion. Virology
`254, 81-91.
`128. Roberts, A., Buonocore, L., Price, R., Forman, J., and Rose, J. K. (1999). Attenuated
`vesicular stomatitis viruses as vaccine vectors. J Virol 73, 3723-32.
`129. Roberts, A, and Rose J.K. (1999) Redesign and genetic dissection of the
`rhabdoviruses. Adv. Virus Res. 53: 301-319.
`130. Haglund K, Forman J, Krausslich HG, Rose JK. (2000) Expression of human
`immunodeficiency virus Type 1 Gag protein precursor and envelope proteins from
`a vesicular stomatitis virus recombinant: high-level production of virus-like
`particles containing HIV envelope.Virology 268: 112-121
`131. Schlereth B, Rose JK, Buonocore L, ter Meulen V, Niewiesk S. (2000) Successful
`vaccine-induced seroconversion by single-dose immunization in the presence of
`measles virus-specific maternal antibodies. J Virol. 74:4652-46577.
`132. Grigera PR, Marzocca MP, Capozzo AV, Buonocore L, Donis RO, Rose JK. (2000)
`Presence of bovine viral diarrhea virus (BVDV) E2 glycoprotein in VSV
`recombinant particles and induction of neutralizing BVDV antibodies in mice.
`Virus Res. 2000 69: 3-15.
`133. Rose NF, Roberts A, Buonocore L, Rose JK. (2000) Glycoprotein exchange vectors
`based on vesicular stomatitis virus allow effective boosting and generation of
`neutralizing antibody to a primary isolate of HIV-1. J. Virol 74:10903-10.
`134. Dalton KP, Rose JK.(2001) Vesicular stomatitis virus glycoprotein containing the
`entire green fluorescent protein on its cytoplasmic domain is incorporated
`efficiently into virus particles. Virology 279:414-421.
`135. Quinones-Kochs, M. I., M. J. Schnell, L. Buonocore, and J. K. Rose. 2001.
`Mechanisms of loss of foreign gene expression in recombinant vesicular stomatitis
`viruses. Virology. 287:427-35.
`136. Rose, J. K., and M. A. Whitt. 2001. Rhabdoviridae: The Viruses and their
`Replication, p. 1221-1244. In D. M. Knipe and P. M. Howley (ed.), Fields Virology,
`4th ed, vol. 1. Lippincott Williams and Wilkins, New York.
`137. Rose, N. F., P. A. Marx, A. Luckay, D. F. Nixon, W. J. Moretto, S. M. Donahoe, D.
`Montefiori, A. Roberts, L. Buonocore, and J. K. Rose. 2001. An effective AIDS
`vaccine based on live attenuated vesicular stomatitis virus recombinants. Cell.
`106:539-49.
`138. Kahn, J.S. , Roberts, A, Weibel, C., Buonocore, L., and Rose, J.K. 2001. Replication-
`competent or attenuated, nonpropagating vesicular stomatitis viruses expressing
`respiratory syncytial virus (RSV) antigens protect mice against RSV challenge. J.
`Virol.. 75:11079-11087.
`139. van den Pol, AN, Dalton, KP and Rose, JK. 2002. Relative neurotropism of a
`recombinant rhabdovirus expressing a green fluorescent envelope glycoprotein. J.
`Virol. 2002. 76: 1309-1327.
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`140. Haglund, K., Leiner, I., Kerksiek, K., Buonocore, L., Pamer, E, and Rose, JK. 2002.
`High-level primary CD8+ T Cell response to HIV-1Gag and Env generated by
`vaccination with recombinant vesicular stomatitis viruses. J. Virol. 76:2730-2738.
`141. Quinones-Kochs, M. I., L. Buonocore, and J. K. Rose. 2002. Role of N-linked glycans
`in a human immunodeficiency virus envelope glycoprotein: effects on protein
`function and the neutralizing antibody response. J. Virol. 76: 4199-4211
`142. Buonocore,L, Blight, KJ, Rice, CM and Rose JK. Characterization of vesicular
`stomatitis virus recombinants that express and incorporate high levels of hepatitis
`C virus glycoproteins. J Virol. 2002 76:6865-72.
`143. Haglund, K., Leiner, I., Kerksiek, K., Buonocore, L., Pamer, E, and Rose, JK. 2002.
`Robust recall and long-term memory T-cell responses induced by prime-boost
`regimens with heterologous live viral vectors expressing human immunodeficiency
`virus type 1 Gag and Env proteins. J. Virol. 76:7506-7517.
`144. Reuter JD, Vivas-Gonzalez BE, Gomez D, Wilson JH, Brandsma JL, Greenstone
`HL, Rose JK, Roberts A. (2002) Intranasal vaccination with a recombinant
`vesicular stomatitis virus expressing cottontail rabbit papillomavirus L1 protein
`provides complete protection against papillomavirus-induced disease. J. Virol.
`76:8900-9.
`145. Okuma, K., K. P. Dalton, L. Buonocore, E. Ramsburg, and J. K. Rose. 2003.
`Development of a novel surrogate virus for human T-cell leukemia virus type 1:
`inhibition of infection by osteoprotegerin. J Virol 77:8562-9.
`146. Schlereth, B., L. Buonocore, A. Tietz, V. Meulen Vt, J. K. Rose, and S. Niewiesk.
`2003. Successful mucosal immunization of cotton rats in the presence of measles
`virus-specific antibodies depends on degree of attenuation of vaccine vector and
`virus dose. J Gen Virol 84:2145-51.
`147. Schlehuber, L., and J.K. Rose. 2004. Prediction and identification of a permissive
`epitope insertion site in the vesicular stomatitis virus glycoprotein. J. Virol.
`78:5079-5087.
`148. Roberts, A., Reuter, J.D., Wilson, J.H., Baldwin, S. and Rose, J.K. 2004. Complete
`protection from papillomavirus challenge after a single vaccination with a
`vesicular stomatitis virus vector expressing high levels of L1 protein. J. Virol.,
`78:3196-3199.
`149. Ramsburg, E., Rose, N.F., Marx, P.A, Mefford, M., Nixon, D.F., Moretto, W.J.,
`Montefiori, D., Earl, P.A., Moss, B, and Rose, J.K. 2004. Highly effective control of
`an AIDS virus challenge in macaques using VSV and MVA vectors in a single-
`boost protocol. J. Virol. 78:3196-3199.
`150. Publicover, J., R